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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HIPK2-BRAF (FusionGDB2 ID:36401)

Fusion Gene Summary for HIPK2-BRAF

Fusion gene summary

Fusion gene information	Fusion gene name: HIPK2-BRAF
	Fusion gene ID: 36401
		Hgene	Tgene
	Gene symbol	HIPK2	BRAF
	Gene ID	28996	673
	Gene name	homeodomain interacting protein kinase 2	B-Raf proto-oncogene, serine/threonine kinase
	Synonyms	PRO0593	B-RAF1\|B-raf\|BRAF1\|NS7\|RAFB1
	Cytomap	7q34	7q34
	Type of gene	protein-coding	protein-coding
	Description	homeodomain-interacting protein kinase 2hHIPk2	serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene
	Modification date	20200313	20200329
	UniProtAcc	.	P15056
	Ensembl transtripts involved in fusion gene	ENST00000342645, ENST00000406875, ENST00000428878,	ENST00000288602,
Fusion gene scores	* DoF score	17 X 13 X 12=2652	48 X 58 X 16=44544
	# samples	25	69
	** MAII score	log2(25/2652*10)=-3.4070807754505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(69/44544*10)=-6.0124909441832 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HIPK2 [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HIPK2(139297947)-BRAF(140449218), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HIPK2	GO:0006468	protein phosphorylation	19448668
Hgene	HIPK2	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	14647468
Hgene	HIPK2	GO:0045766	positive regulation of angiogenesis	19046997
Hgene	HIPK2	GO:0060395	SMAD protein signal transduction	12874272
Tgene	BRAF	GO:0000186	activation of MAPKK activity	29433126
Tgene	BRAF	GO:0006468	protein phosphorylation	17563371
Tgene	BRAF	GO:0010828	positive regulation of glucose transmembrane transport	23010278
Tgene	BRAF	GO:0033138	positive regulation of peptidyl-serine phosphorylation	19667065
Tgene	BRAF	GO:0043066	negative regulation of apoptotic process	19667065
Tgene	BRAF	GO:0070374	positive regulation of ERK1 and ERK2 cascade	22065586
Tgene	BRAF	GO:0071277	cellular response to calcium ion	18567582
Tgene	BRAF	GO:0090150	establishment of protein localization to membrane	23010278

Fusion gene breakpoints across HIPK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BRAF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-A92D	HIPK2	chr7	139297947	-	BRAF	chr7	140449218	-

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Fusion Gene ORF analysis for HIPK2-BRAF

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000342645	ENST00000288602	HIPK2	chr7	139297947	-	BRAF	chr7	140449218	-
In-frame	ENST00000406875	ENST00000288602	HIPK2	chr7	139297947	-	BRAF	chr7	140449218	-
In-frame	ENST00000428878	ENST00000288602	HIPK2	chr7	139297947	-	BRAF	chr7	140449218	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000406875	HIPK2	chr7	139297947	-	ENST00000288602	BRAF	chr7	140449218	-	2766	2207	95	2647	850
ENST00000428878	HIPK2	chr7	139297947	-	ENST00000288602	BRAF	chr7	140449218	-	2745	2186	155	2626	823
ENST00000342645	HIPK2	chr7	139297947	-	ENST00000288602	BRAF	chr7	140449218	-	2671	2112	21	2552	843

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000406875	ENST00000288602	HIPK2	chr7	139297947	-	BRAF	chr7	140449218	-	0.004015429	0.99598455
ENST00000428878	ENST00000288602	HIPK2	chr7	139297947	-	BRAF	chr7	140449218	-	0.005234031	0.994766
ENST00000342645	ENST00000288602	HIPK2	chr7	139297947	-	BRAF	chr7	140449218	-	0.003625919	0.9963741

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Fusion Genomic Features for HIPK2-BRAF

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HIPK2-BRAF

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:139297947/chr7:140449218)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	BRAF P15056
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269\|PubMed:1508179, ECO:0000269\|PubMed:21441910, ECO:0000269\|PubMed:29433126, ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000406875

199_527

704

1199.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000428878

199_527

677

1172.0

Domain

Protein kinase

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000406875

205_213

704

1199.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000428878

205_213

677

1172.0

Nucleotide binding

ATP

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000406875

97_230

704

1199.0

Region

Transcriptional corepression

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000428878

97_230

677

1172.0

Region

Transcriptional corepression

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000406875

1088_1094

704

1199.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000428878

1088_1094

677

1172.0

Compositional bias

Note=Poly-Ala

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000406875

802_805

704

1199.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000406875

832_835

704

1199.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000428878

802_805

677

1172.0

Motif

Note=Nuclear localization signal 1 (NLS1)

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000428878

832_835

677

1172.0

Motif

Note=Nuclear localization signal 2 (NLS2)

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000406875

873_980

704

1199.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000406875

984_1198

704

1199.0

Region

Note=Autoinhibitory domain (AID)

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000428878

873_980

677

1172.0

Region

Required for localization to nuclear speckles

Hgene

HIPK2

chr7:139297947

chr7:140449218

ENST00000428878

984_1198

677

1172.0

Region

Note=Autoinhibitory domain (AID)

Tgene

BRAF

chr7:139297947

chr7:140449218

ENST00000288602

122_129

620

767.0

Compositional bias

Note=Poly-Ser

Tgene

BRAF

chr7:139297947

chr7:140449218

ENST00000288602

428_432

620

767.0

Compositional bias

Note=Poly-Ser

Tgene

BRAF

chr7:139297947

chr7:140449218

ENST00000288602

6_11

620

767.0

Compositional bias

Note=Poly-Gly

Tgene

BRAF

chr7:139297947

chr7:140449218

ENST00000288602

155_227

620

767.0

Domain

RBD

Tgene

BRAF

chr7:139297947

chr7:140449218

ENST00000288602

457_717

620

767.0

Domain

Protein kinase

Tgene

BRAF

chr7:139297947

chr7:140449218

ENST00000288602

463_471

620

767.0

Nucleotide binding

ATP

Tgene

BRAF

chr7:139297947

chr7:140449218

ENST00000288602

234_280

620

767.0

Zinc finger

Phorbol-ester/DAG-type

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Fusion Gene Sequence for HIPK2-BRAF

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>36401_36401_1_HIPK2-BRAF_HIPK2_chr7_139297947_ENST00000342645_BRAF_chr7_140449218_ENST00000288602_length(transcript)=2671nt_BP=2112nt
CTTCAGCCTGTTTATGAGAGTATGGCCTCACATGTGCAAGTTTTCTCCCCTCACACCCTTCAATCAAGTGCCTTCTGTAGTGTGAAGAAA
CTGAAAATAGAGCCGAGTTCCAACTGGGACATGACTGGGTACGGCTCCCACAGCAAAGTGTATAGCCAGAGCAAGAACATCCCCCTGTCG
CAGCCAGCCACCACAACCGTCAGCACCTCCTTGCCGGTCCCAAACCCAAGCCTACCTTACGAGCAGACCATCGTCTTCCCAGGAAGCACC
GGGCACATCGTGGTCACCTCAGCAAGCAGCACTTCTGTCACCGGGCAAGTCCTCGGCGGACCACACAACCTAATGCGTCGAAGCACTGTG
AGCCTCCTTGATACCTACCAAAAATGTGGACTCAAGCGTAAGAGCGAGGAGATCGAGAACACAAGCAGCGTGCAGATCATCGAGGAGCAT
CCACCCATGATTCAGAATAATGCAAGCGGGGCCACTGTCGCCACTGCCACCACGTCTACTGCCACCTCCAAAAACAGCGGCTCCAACAGC
GAGGGCGACTATCAGCTGGTGCAGCATGAGGTGCTGTGCTCCATGACCAACACCTACGAGGTCTTAGAGTTCTTGGGCCGAGGGACGTTT
GGGCAAGTGGTCAAGTGCTGGAAACGGGGCACCAATGAGATCGTAGCCATCAAGATCCTGAAGAACCACCCATCCTATGCCCGACAAGGT
CAGATTGAAGTGAGCATCCTGGCCCGGTTGAGCACGGAGAGTGCCGATGACTATAACTTCGTCCGGGCCTACGAATGCTTCCAGCACAAG
AACCACACGTGCTTGGTCTTCGAGATGTTGGAGCAGAACCTCTATGACTTTCTGAAGCAAAACAAGTTTAGCCCCTTGCCCCTCAAATAC
ATTCGCCCAGTTCTCCAGCAGGTAGCCACAGCCCTGATGAAACTCAAAAGCCTAGGTCTTATCCACGCTGACCTCAAACCAGAAAACATC
ATGCTGGTGGATCCATCTAGACAACCATACAGAGTCAAGGTCATCGACTTTGGTTCAGCCAGCCACGTCTCCAAGGCTGTGTGCTCCACC
TACTTGCAGTCCAGATATTACAGGGCCCCTGAGATCATCCTTGGTTTACCATTTTGTGAGGCAATTGACATGTGGTCCCTGGGCTGTGTT
ATTGCAGAATTGTTCCTGGGTTGGCCGTTATATCCAGGAGCTTCGGAGTATGATCAGATTCGGTATATTTCACAAACACAGGGTTTGCCT
GCTGAATATTTATTAAGCGCCGGGACAAAGACAACTAGGTTTTTCAACCGTGACACGGACTCACCATATCCTTTGTGGAGACTGAAGACA
CCAGATGACCATGAAGCAGAGACAGGGATTAAGTCAAAAGAAGCAAGAAAGTACATTTTCAACTGTTTAGATGATATGGCCCAGGTGAAC
ATGACGACAGATTTGGAAGGGAGCGACATGTTGGTAGAAAAGGCTGACCGGCGGGAGTTCATTGACCTGTTGAAGAAGATGCTGACCATT
GATGCTGACAAGAGAATCACTCCAATCGAAACCCTGAACCATCCCTTTGTCACCATGACACACTTACTCGATTTTCCCCACAGCACACAC
GTCAAATCATGTTTCCAGAACATGGAGATCTGCAAGCGTCGGGTGAATATGTATGACACGGTGAACCAGAGCAAAACCCCTTTCATCACG
CACGTGGCCCCCAGCACGTCCACCAACCTGACCATGACCTTTAACAACCAGCTGACCACTGTCCACAACCAGGCTCCCTCCTCTACCAGT
GCCACTATTTCCTTAGCCAATCCCGAAGTCTCCATACTAAACTACCCATCTACACTCTACCAGCCCTCAGCGGCATCCATGGCTGCAGTG
GCCCAGCGGAGCATGCCCCTGCAGACAGGAACAGCCCAGATTTGTGCCCGGCCTGACCCGTTCCAGCAAGCTCTCATCGTGTGTCCCCCC
GGCTTCCAAGGCTTGCAGGCCTCTCCCTCTAAGCACGCTGGCTACTCGGTGCGAATGGAAAATGCAGTTCCCATCGTCACTCAAGCCCCA
GGAGCTCAGCCTCTTCAGATCCAACCAGGTCTGCTTGCCCAGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAG
TCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATT
TTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGC
CTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGC
AGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAG
GCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATA

>36401_36401_1_HIPK2-BRAF_HIPK2_chr7_139297947_ENST00000342645_BRAF_chr7_140449218_ENST00000288602_length(amino acids)=843AA_BP=691
MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTS
ASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLV
QHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVF
EMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYY
RAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAE
TGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQN
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPL
QTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQAPEVIRMQDKNPYSFQSDVYAFG
IVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSL

--------------------------------------------------------------
>36401_36401_2_HIPK2-BRAF_HIPK2_chr7_139297947_ENST00000406875_BRAF_chr7_140449218_ENST00000288602_length(transcript)=2766nt_BP=2207nt
CTCAAGATGGCAGATTCCGACTGAGGCTGGGGGGGCCGAGCTCGCGCGCCGCTTTCCCGTCCCCGTTGCCATGAACCGCGGACACCCCGG
CCCCGATGGCCCCCGTGTACGAAGGTATGGCCTCACATGTGCAAGTTTTCTCCCCTCACACCCTTCAATCAAGTGCCTTCTGTAGTGTGA
AGAAACTGAAAATAGAGCCGAGTTCCAACTGGGACATGACTGGGTACGGCTCCCACAGCAAAGTGTATAGCCAGAGCAAGAACATCCCCC
TGTCGCAGCCAGCCACCACAACCGTCAGCACCTCCTTGCCGGTCCCAAACCCAAGCCTACCTTACGAGCAGACCATCGTCTTCCCAGGAA
GCACCGGGCACATCGTGGTCACCTCAGCAAGCAGCACTTCTGTCACCGGGCAAGTCCTCGGCGGACCACACAACCTAATGCGTCGAAGCA
CTGTGAGCCTCCTTGATACCTACCAAAAATGTGGACTCAAGCGTAAGAGCGAGGAGATCGAGAACACAAGCAGCGTGCAGATCATCGAGG
AGCATCCACCCATGATTCAGAATAATGCAAGCGGGGCCACTGTCGCCACTGCCACCACGTCTACTGCCACCTCCAAAAACAGCGGCTCCA
ACAGCGAGGGCGACTATCAGCTGGTGCAGCATGAGGTGCTGTGCTCCATGACCAACACCTACGAGGTCTTAGAGTTCTTGGGCCGAGGGA
CGTTTGGGCAAGTGGTCAAGTGCTGGAAACGGGGCACCAATGAGATCGTAGCCATCAAGATCCTGAAGAACCACCCATCCTATGCCCGAC
AAGGTCAGATTGAAGTGAGCATCCTGGCCCGGTTGAGCACGGAGAGTGCCGATGACTATAACTTCGTCCGGGCCTACGAATGCTTCCAGC
ACAAGAACCACACGTGCTTGGTCTTCGAGATGTTGGAGCAGAACCTCTATGACTTTCTGAAGCAAAACAAGTTTAGCCCCTTGCCCCTCA
AATACATTCGCCCAGTTCTCCAGCAGGTAGCCACAGCCCTGATGAAACTCAAAAGCCTAGGTCTTATCCACGCTGACCTCAAACCAGAAA
ACATCATGCTGGTGGATCCATCTAGACAACCATACAGAGTCAAGGTCATCGACTTTGGTTCAGCCAGCCACGTCTCCAAGGCTGTGTGCT
CCACCTACTTGCAGTCCAGATATTACAGGGCCCCTGAGATCATCCTTGGTTTACCATTTTGTGAGGCAATTGACATGTGGTCCCTGGGCT
GTGTTATTGCAGAATTGTTCCTGGGTTGGCCGTTATATCCAGGAGCTTCGGAGTATGATCAGATTCGGTATATTTCACAAACACAGGGTT
TGCCTGCTGAATATTTATTAAGCGCCGGGACAAAGACAACTAGGTTTTTCAACCGTGACACGGACTCACCATATCCTTTGTGGAGACTGA
AGACACCAGATGACCATGAAGCAGAGACAGGGATTAAGTCAAAAGAAGCAAGAAAGTACATTTTCAACTGTTTAGATGATATGGCCCAGG
TGAACATGACGACAGATTTGGAAGGGAGCGACATGTTGGTAGAAAAGGCTGACCGGCGGGAGTTCATTGACCTGTTGAAGAAGATGCTGA
CCATTGATGCTGACAAGAGAATCACTCCAATCGAAACCCTGAACCATCCCTTTGTCACCATGACACACTTACTCGATTTTCCCCACAGCA
CACACGTCAAATCATGTTTCCAGAACATGGAGATCTGCAAGCGTCGGGTGAATATGTATGACACGGTGAACCAGAGCAAAACCCCTTTCA
TCACGCACGTGGCCCCCAGCACGTCCACCAACCTGACCATGACCTTTAACAACCAGCTGACCACTGTCCACAACCAGGCTCCCTCCTCTA
CCAGTGCCACTATTTCCTTAGCCAATCCCGAAGTCTCCATACTAAACTACCCATCTACACTCTACCAGCCCTCAGCGGCATCCATGGCTG
CAGTGGCCCAGCGGAGCATGCCCCTGCAGACAGGAACAGCCCAGATTTGTGCCCGGCCTGACCCGTTCCAGCAAGCTCTCATCGTGTGTC
CCCCCGGCTTCCAAGGCTTGCAGGCCTCTCCCTCTAAGCACGCTGGCTACTCGGTGCGAATGGAAAATGCAGTTCCCATCGTCACTCAAG
CCCCAGGAGCTCAGCCTCTTCAGATCCAACCAGGTCTGCTTGCCCAGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCT
TTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGA
TAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAG
AGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTC
ACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCA
TCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGA

>36401_36401_2_HIPK2-BRAF_HIPK2_chr7_139297947_ENST00000406875_BRAF_chr7_140449218_ENST00000288602_length(amino acids)=850AA_BP=698
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT
PDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAV
AQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQAPEVIRMQDKNPYSFQ
SDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHR

--------------------------------------------------------------
>36401_36401_3_HIPK2-BRAF_HIPK2_chr7_139297947_ENST00000428878_BRAF_chr7_140449218_ENST00000288602_length(transcript)=2745nt_BP=2186nt
CACGGGAGGCGGTGATGCGGGCGCGGGCGGCCTCGGCTGCGCCGAGAGCGGAGACACAGGCTCAAGATGGCAGATTCCGACTGAGGCTGG
GGGGGCCGAGCTCGCGCGCCGCTTTCCCGTCCCCGTTGCCATGAACCGCGGACACCCCGGCCCCGATGGCCCCCGTGTACGAAGGTATGG
CCTCACATGTGCAAGTTTTCTCCCCTCACACCCTTCAATCAAGTGCCTTCTGTAGTGTGAAGAAACTGAAAATAGAGCCGAGTTCCAACT
GGGACATGACTGGGTACGGCTCCCACAGCAAAGTGTATAGCCAGAGCAAGAACATCCCCCTGTCGCAGCCAGCCACCACAACCGTCAGCA
CCTCCTTGCCGGTCCCAAACCCAAGCCTACCTTACGAGCAGACCATCGTCTTCCCAGGAAGCACCGGGCACATCGTGGTCACCTCAGCAA
GCAGCACTTCTGTCACCGGGCAAGTCCTCGGCGGACCACACAACCTAATGCGTCGAAGCACTGTGAGCCTCCTTGATACCTACCAAAAAT
GTGGACTCAAGCGTAAGAGCGAGGAGATCGAGAACACAAGCAGCGTGCAGATCATCGAGGAGCATCCACCCATGATTCAGAATAATGCAA
GCGGGGCCACTGTCGCCACTGCCACCACGTCTACTGCCACCTCCAAAAACAGCGGCTCCAACAGCGAGGGCGACTATCAGCTGGTGCAGC
ATGAGGTGCTGTGCTCCATGACCAACACCTACGAGGTCTTAGAGTTCTTGGGCCGAGGGACGTTTGGGCAAGTGGTCAAGTGCTGGAAAC
GGGGCACCAATGAGATCGTAGCCATCAAGATCCTGAAGAACCACCCATCCTATGCCCGACAAGGTCAGATTGAAGTGAGCATCCTGGCCC
GGTTGAGCACGGAGAGTGCCGATGACTATAACTTCGTCCGGGCCTACGAATGCTTCCAGCACAAGAACCACACGTGCTTGGTCTTCGAGA
TGTTGGAGCAGAACCTCTATGACTTTCTGAAGCAAAACAAGTTTAGCCCCTTGCCCCTCAAATACATTCGCCCAGTTCTCCAGCAGGTAG
CCACAGCCCTGATGAAACTCAAAAGCCTAGGTCTTATCCACGCTGACCTCAAACCAGAAAACATCATGCTGGTGGATCCATCTAGACAAC
CATACAGAGTCAAGGTCATCGACTTTGGTTCAGCCAGCCACGTCTCCAAGGCTGTGTGCTCCACCTACTTGCAGTCCAGATATTACAGGG
CCCCTGAGATCATCCTTGGTTTACCATTTTGTGAGGCAATTGACATGTGGTCCCTGGGCTGTGTTATTGCAGAATTGTTCCTGGGTTGGC
CGTTATATCCAGGAGCTTCGGAGTATGATCAGATTCGGTATATTTCACAAACACAGGGTTTGCCTGCTGAATATTTATTAAGCGCCGGGA
CAAAGACAACTAGGTTTTTCAACCGTGACACGGACTCACCATATCCTTTGTGGAGACTGAAGACACCAGATGACCATGAAGCAGAGACAG
GGATTAAGTCAAAAGAAGCAAGAAAGTACATTTTCAACTGTTTAGATGATATGGCCCAGGTGAACATGACGACAGATTTGGAAGGGAGCG
ACATGTTGGTAGAAAAGGCTGACCGGCGGGAGTTCATTGACCTGTTGAAGAAGATGCTGACCATTGATGCTGACAAGAGAATCACTCCAA
TCGAAACCCTGAACCATCCCTTTGTCACCATGACACACTTACTCGATTTTCCCCACAGCACACACGTCAAATCATGTTTCCAGAACATGG
AGATCTGCAAGCGTCGGGTGAATATGTATGACACGGTGAACCAGAGCAAAACCCCTTTCATCACGCACGTGGCCCCCAGCACGTCCACCA
ACCTGACCATGACCTTTAACAACCAGCTGACCACTGTCCACAACCAGCCCTCAGCGGCATCCATGGCTGCAGTGGCCCAGCGGAGCATGC
CCCTGCAGACAGGAACAGCCCAGATTTGTGCCCGGCCTGACCCGTTCCAGCAAGCTCTCATCGTGTGTCCCCCCGGCTTCCAAGGCTTGC
AGGCCTCTCCCTCTAAGCACGCTGGCTACTCGGTGCGAATGGAAAATGCAGTTCCCATCGTCACTCAAGCCCCAGGAGCTCAGCCTCTTC
AGATCCAACCAGGTCTGCTTGCCCAGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCAT
TTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAG
GATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAG
ATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCT
CCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTG
CGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTT

>36401_36401_3_HIPK2-BRAF_HIPK2_chr7_139297947_ENST00000428878_BRAF_chr7_140449218_ENST00000288602_length(amino acids)=823AA_BP=671
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT
PDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIV
CPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKT

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Fusion Gene PPI Analysis for HIPK2-BRAF

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000406875	-	9	15	189_520	704.0	1199.0	DAXX
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000428878	-	9	15	189_520	677.0	1172.0	DAXX

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000406875	-	9	15	935_1049	704.0	1199.0	AXIN1
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000428878	-	9	15	935_1049	677.0	1172.0	AXIN1
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000406875	-	9	15	774_876	704.0	1199.0	CTBP1
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000428878	-	9	15	774_876	677.0	1172.0	CTBP1
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000406875	-	9	15	787_897	704.0	1199.0	HMGA1
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000428878	-	9	15	787_897	677.0	1172.0	HMGA1
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000406875	-	9	15	752_897	704.0	1199.0	POU4F1
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000428878	-	9	15	752_897	677.0	1172.0	POU4F1
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000406875	-	9	15	539_844	704.0	1199.0	SKI and SMAD1
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000428878	-	9	15	539_844	677.0	1172.0	SKI and SMAD1
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000406875	-	9	15	846_941	704.0	1199.0	TP53 and TP73
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000428878	-	9	15	846_941	677.0	1172.0	TP53 and TP73
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000406875	-	9	15	873_907	704.0	1199.0	UBE2I
Hgene	HIPK2	chr7:139297947	chr7:140449218	ENST00000428878	-	9	15	873_907	677.0	1172.0	UBE2I

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HIPK2-BRAF

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HIPK2-BRAF

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source