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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:HIRA-ADAM2 (FusionGDB2 ID:36428)

Fusion Gene Summary for HIRA-ADAM2

Fusion gene summary

Fusion gene information	Fusion gene name: HIRA-ADAM2
	Fusion gene ID: 36428
		Hgene	Tgene
	Gene symbol	HIRA	ADAM2
	Gene ID	7290	2515
	Gene name	histone cell cycle regulator	ADAM metallopeptidase domain 2
	Synonyms	DGCR1\|TUP1\|TUPLE1	CRYN1\|CRYN2\|CT15\|FTNB\|PH-30b\|PH30\|PH30-beta
	Cytomap	22q11.21	8p11.22
	Type of gene	protein-coding	protein-coding
	Description	protein HIRADiGeorge critical region gene 1HIR histone cell cycle regulation defective homolog ATUP1-like enhancer of split protein 1histone regulator A	disintegrin and metalloproteinase domain-containing protein 2cancer/testis antigen 15fertilin subunit beta
	Modification date	20200313	20200313
	UniProtAcc	P54198	Q9UKF5
	Ensembl transtripts involved in fusion gene	ENST00000263208, ENST00000340170, ENST00000541063, ENST00000546308, ENST00000464189,	ENST00000523181, ENST00000265708, ENST00000347580, ENST00000379853, ENST00000521880,
Fusion gene scores	* DoF score	18 X 15 X 9=2430	7 X 8 X 4=224
	# samples	23	10
	** MAII score	log2(23/2430*10)=-3.40125054754877 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/224*10)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HIRA [Title/Abstract] AND ADAM2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HIRA(19393309)-ADAM2(39627094), # samples:3
Anticipated loss of major functional domain due to fusion event.	HIRA-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. HIRA-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. HIRA-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. HIRA-ADAM2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HIRA	GO:0006336	DNA replication-independent nucleosome assembly	14718166

Fusion gene breakpoints across HIRA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADAM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-44-8117-01A	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-

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Fusion Gene ORF analysis for HIRA-ADAM2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000263208	ENST00000523181	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
5CDS-intron	ENST00000340170	ENST00000523181	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
5CDS-intron	ENST00000541063	ENST00000523181	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
5CDS-intron	ENST00000546308	ENST00000523181	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
5UTR-3CDS	ENST00000464189	ENST00000265708	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
5UTR-3CDS	ENST00000464189	ENST00000347580	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
5UTR-3CDS	ENST00000464189	ENST00000379853	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
5UTR-3CDS	ENST00000464189	ENST00000521880	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
5UTR-intron	ENST00000464189	ENST00000523181	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
Frame-shift	ENST00000263208	ENST00000265708	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
Frame-shift	ENST00000263208	ENST00000347580	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
Frame-shift	ENST00000263208	ENST00000379853	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
Frame-shift	ENST00000263208	ENST00000521880	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
Frame-shift	ENST00000340170	ENST00000265708	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
Frame-shift	ENST00000340170	ENST00000347580	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
Frame-shift	ENST00000340170	ENST00000379853	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
Frame-shift	ENST00000340170	ENST00000521880	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
In-frame	ENST00000541063	ENST00000265708	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
In-frame	ENST00000541063	ENST00000347580	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
In-frame	ENST00000541063	ENST00000379853	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
In-frame	ENST00000541063	ENST00000521880	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
In-frame	ENST00000546308	ENST00000265708	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
In-frame	ENST00000546308	ENST00000347580	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
In-frame	ENST00000546308	ENST00000379853	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-
In-frame	ENST00000546308	ENST00000521880	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000541063	HIRA	chr22	19393309	-	ENST00000347580	ADAM2	chr8	39627094	-	1937	397	542	1576	344
ENST00000541063	HIRA	chr22	19393309	-	ENST00000379853	ADAM2	chr8	39627094	-	1847	397	542	1486	314
ENST00000541063	HIRA	chr22	19393309	-	ENST00000265708	ADAM2	chr8	39627094	-	1937	397	542	1576	344
ENST00000541063	HIRA	chr22	19393309	-	ENST00000521880	ADAM2	chr8	39627094	-	1452	397	542	1387	281
ENST00000546308	HIRA	chr22	19393309	-	ENST00000347580	ADAM2	chr8	39627094	-	2095	555	700	1734	344
ENST00000546308	HIRA	chr22	19393309	-	ENST00000379853	ADAM2	chr8	39627094	-	2005	555	700	1644	314
ENST00000546308	HIRA	chr22	19393309	-	ENST00000265708	ADAM2	chr8	39627094	-	2095	555	700	1734	344
ENST00000546308	HIRA	chr22	19393309	-	ENST00000521880	ADAM2	chr8	39627094	-	1610	555	700	1545	281

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000541063	ENST00000347580	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.000387983	0.99961203
ENST00000541063	ENST00000379853	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.00168073	0.9983192
ENST00000541063	ENST00000265708	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.000387983	0.99961203
ENST00000541063	ENST00000521880	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.001188296	0.9988117
ENST00000546308	ENST00000347580	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.000513156	0.9994868
ENST00000546308	ENST00000379853	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.002234545	0.9977654
ENST00000546308	ENST00000265708	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.000513156	0.9994868
ENST00000546308	ENST00000521880	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.001529105	0.99847084

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Fusion Genomic Features for HIRA-ADAM2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HIRA-ADAM2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:19393309/chr8:39627094)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HIRA P54198	ADAM2 Q9UKF5
FUNCTION: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269\|PubMed:12370293, ECO:0000269\|PubMed:14718166, ECO:0000269\|PubMed:15621527}.	FUNCTION: May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

11_53

132

1018.0

Repeat

Note=WD 1

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

68_107

132

1018.0

Repeat

Note=WD 2

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

11_53

132

811.0

Repeat

Note=WD 1

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

68_107

132

811.0

Repeat

Note=WD 2

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

477_606

342

788.6666666666666

Compositional bias

Note=Cys-rich

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

477_606

323

796.3333333333334

Compositional bias

Note=Cys-rich

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

384_473

342

788.6666666666666

Domain

Disintegrin

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

612_645

342

788.6666666666666

Domain

Note=EGF-like

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

384_473

323

796.3333333333334

Domain

Disintegrin

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

612_645

323

796.3333333333334

Domain

Note=EGF-like

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

708_735

342

788.6666666666666

Topological domain

Cytoplasmic

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

708_735

323

796.3333333333334

Topological domain

Cytoplasmic

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

687_707

342

788.6666666666666

Transmembrane

Helical

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

687_707

323

796.3333333333334

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

408_412

132

1018.0

Compositional bias

Note=Poly-Gln

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

640_643

132

1018.0

Compositional bias

Note=Poly-Lys

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

805_808

132

1018.0

Compositional bias

Note=Poly-Val

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

408_412

132

811.0

Compositional bias

Note=Poly-Gln

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

640_643

132

811.0

Compositional bias

Note=Poly-Lys

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

805_808

132

811.0

Compositional bias

Note=Poly-Val

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

439_475

132

1018.0

Region

Note=Required for repression of histone gene transcription

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

439_475

132

811.0

Region

Note=Required for repression of histone gene transcription

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

129_168

132

1018.0

Repeat

Note=WD 3

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

172_211

132

1018.0

Repeat

Note=WD 4

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

220_263

132

1018.0

Repeat

Note=WD 5

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

266_322

132

1018.0

Repeat

Note=WD 6

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

326_367

132

1018.0

Repeat

Note=WD 7

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

129_168

132

811.0

Repeat

Note=WD 3

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

172_211

132

811.0

Repeat

Note=WD 4

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

220_263

132

811.0

Repeat

Note=WD 5

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

266_322

132

811.0

Repeat

Note=WD 6

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

326_367

132

811.0

Repeat

Note=WD 7

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

178_375

342

788.6666666666666

Domain

Peptidase M12B

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

178_375

323

796.3333333333334

Domain

Peptidase M12B

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

175_686

342

788.6666666666666

Topological domain

Extracellular

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

175_686

323

796.3333333333334

Topological domain

Extracellular

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Fusion Gene Sequence for HIRA-ADAM2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>36428_36428_1_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000541063_ADAM2_chr8_39627094_ENST00000265708_length(transcript)=1937nt_BP=397nt
CGGTCGCCCAGACATGGCGGACGGCAGCGGCTGGCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACT
GGAGGACAAGGGCAGGATTCTGGGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCC
AAGATGCTTTGCCAGATGGACAATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGAT
GACAAACTGATTATGGTGTGGAAGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAG
TGGCGGTGTGTCTCTATCCTCCGGAATCATTCAGGCGTCATTTCAGTGGTGTGAAGATCTTTAGTAACTGCAGCTTCGAAGACTTTGCAC
ATTTTATTTCAAAGCAGAAGTCCCAGTGTCTTCACAATCAGCCTCGCTTAGATCCTTTTTTCAAACAGCAAGCAGTGTGTGGTAATGCAA
AGCTGGAAGCAGGAGAGGAGTGTGACTGTGGGACTGAACAGGATTGTGCCCTTATTGGAGAAACATGCTGTGATATTGCCACATGTAGAT
TTAAAGCCGGTTCAAACTGTGCTGAAGGACCATGCTGCGAAAACTGTCTATTTATGTCAAAAGAAAGAATGTGTAGGCCTTCCTTTGAAG
AATGCGACCTCCCTGAATATTGCAATGGATCATCTGCATCATGCCCAGAAAACCACTATGTTCAGACTGGGCATCCGTGTGGACTGAATC
AATGGATCTGTATAGATGGAGTTTGTATGAGTGGGGATAAACAATGTACAGACACATTTGGCAAAGAAGTAGAGTTTGGCCCTTCAGAAT
GTTATTCTCACCTTAATTCAAAGACTGATGTATCTGGAAACTGTGGTATAAGTGATTCAGGATACACACAGTGTGAAGCTGACAATCTGC
AGTGCGGAAAATTAATATGTAAATATGTAGGTAAATTTTTATTACAAATTCCAAGAGCCACTATTATTTATGCCAACATAAGTGGACATC
TCTGCATTGCTGTGGAATTTGCCAGTGATCATGCAGACAGCCAAAAGATGTGGATAAAAGATGGAACTTCTTGTGGTTCAAATAAGGTTT
GCAGGAATCAAAGATGTGTGAGTTCTTCATACTTGGGTTATGATTGTACTACTGACAAATGCAATGATAGAGGTGTATGCAATAACAAAA
AGCACTGTCACTGTAGTGCTTCATATTTACCTCCAGATTGCTCAGTTCAATCAGATCTATGGCCTGGTGGGAGTATTGACAGTGGCAATT
TTCCACCTGTAGCTATACCAGCCAGACTCCCTGAAAGGCGCTACATTGAGAACATTTACCATTCCAAACCAATGAGATGGCCATTTTTCT
TATTCATTCCTTTCTTTATTATTTTCTGTGTACTGATTGCTATAATGGTGAAAGTTAATTTCCAAAGGAAAAAATGGAGAACTGAGGACT
ATTCAAGCGATGAGCAACCTGAAAGTGAGAGTGAACCTAAAGGGTAGTCTGGACAACAGAGATGCCATGATATCACTTCTTCTAGAGTAA
TTATCTGTGATGGATGGACACAAAAAAATGGAAAGAAAAGAATGTACATTACCTGGTTTCCTGGGATTCAAACCTGCATATTGTGATTTT
AATTTGACCAGAAAATATGATATATATGTATAATTTCACAGATAATTTACTTATTTAAAAATGCATGATAATGAGTTTTACATTACAAAT
TTCTGTTTTTTTAAAGTTATCTTACGCTATTTCTGTTGGTTAGTAGACACTAATTCTGTCAGTAGGGGCATGGTATAAGGAAATATCATA

>36428_36428_1_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000541063_ADAM2_chr8_39627094_ENST00000265708_length(amino acids)=344AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHL
CIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNF

--------------------------------------------------------------
>36428_36428_2_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000541063_ADAM2_chr8_39627094_ENST00000347580_length(transcript)=1937nt_BP=397nt
CGGTCGCCCAGACATGGCGGACGGCAGCGGCTGGCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACT
GGAGGACAAGGGCAGGATTCTGGGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCC
AAGATGCTTTGCCAGATGGACAATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGAT
GACAAACTGATTATGGTGTGGAAGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAG
TGGCGGTGTGTCTCTATCCTCCGGAATCATTCAGGCGTCATTTCAGTGGTGTGAAGATCTTTAGTAACTGCAGCTTCGAAGACTTTGCAC
ATTTTATTTCAAAGCAGAAGTCCCAGTGTCTTCACAATCAGCCTCGCTTAGATCCTTTTTTCAAACAGCAAGCAGTGTGTGGTAATGCAA
AGCTGGAAGCAGGAGAGGAGTGTGACTGTGGGACTGAACAGGATTGTGCCCTTATTGGAGAAACATGCTGTGATATTGCCACATGTAGAT
TTAAAGCCGGTTCAAACTGTGCTGAAGGACCATGCTGCGAAAACTGTCTATTTATGTCAAAAGAAAGAATGTGTAGGCCTTCCTTTGAAG
AATGCGACCTCCCTGAATATTGCAATGGATCATCTGCATCATGCCCAGAAAACCACTATGTTCAGACTGGGCATCCGTGTGGACTGAATC
AATGGATCTGTATAGATGGAGTTTGTATGAGTGGGGATAAACAATGTACAGACACATTTGGCAAAGAAGTAGAGTTTGGCCCTTCAGAAT
GTTATTCTCACCTTAATTCAAAGACTGATGTATCTGGAAACTGTGGTATAAGTGATTCAGGATACACACAGTGTGAAGCTGACAATCTGC
AGTGCGGAAAATTAATATGTAAATATGTAGGTAAATTTTTATTACAAATTCCAAGAGCCACTATTATTTATGCCAACATAAGTGGACATC
TCTGCATTGCTGTGGAATTTGCCAGTGATCATGCAGACAGCCAAAAGATGTGGATAAAAGATGGAACTTCTTGTGGTTCAAATAAGGTTT
GCAGGAATCAAAGATGTGTGAGTTCTTCATACTTGGGTTATGATTGTACTACTGACAAATGCAATGATAGAGGTGTATGCAATAACAAAA
AGCACTGTCACTGTAGTGCTTCATATTTACCTCCAGATTGCTCAGTTCAATCAGATCTATGGCCTGGTGGGAGTATTGACAGTGGCAATT
TTCCACCTGTAGCTATACCAGCCAGACTCCCTGAAAGGCGCTACATTGAGAACATTTACCATTCCAAACCAATGAGATGGCCATTTTTCT
TATTCATTCCTTTCTTTATTATTTTCTGTGTACTGATTGCTATAATGGTGAAAGTTAATTTCCAAAGGAAAAAATGGAGAACTGAGGACT
ATTCAAGCGATGAGCAACCTGAAAGTGAGAGTGAACCTAAAGGGTAGTCTGGACAACAGAGATGCCATGATATCACTTCTTCTAGAGTAA
TTATCTGTGATGGATGGACACAAAAAAATGGAAAGAAAAGAATGTACATTACCTGGTTTCCTGGGATTCAAACCTGCATATTGTGATTTT
AATTTGACCAGAAAATATGATATATATGTATAATTTCACAGATAATTTACTTATTTAAAAATGCATGATAATGAGTTTTACATTACAAAT
TTCTGTTTTTTTAAAGTTATCTTACGCTATTTCTGTTGGTTAGTAGACACTAATTCTGTCAGTAGGGGCATGGTATAAGGAAATATCATA

>36428_36428_2_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000541063_ADAM2_chr8_39627094_ENST00000347580_length(amino acids)=344AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHL
CIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNF

--------------------------------------------------------------
>36428_36428_3_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000541063_ADAM2_chr8_39627094_ENST00000379853_length(transcript)=1847nt_BP=397nt
CGGTCGCCCAGACATGGCGGACGGCAGCGGCTGGCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACT
GGAGGACAAGGGCAGGATTCTGGGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCC
AAGATGCTTTGCCAGATGGACAATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGAT
GACAAACTGATTATGGTGTGGAAGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAG
TGGCGGTGTGTCTCTATCCTCCGGAATCATTCAGGCGTCATTTCAGTGGTGTGAAGATCTTTAGTAACTGCAGCTTCGAAGACTTTGCAC
ATTTTATTTCAAAGCAGAAGTCCCAGTGTCTTCACAATCAGCCTCGCTTAGATCCTTTTTTCAAACAGCAAGCAGTGTGTGGTAATGCAA
AGCTGGAAGCAGGAGAGGAGTGTGACTGTGGGACTGAACAGGATTGTGCCCTTATTGGAGAAACATGCTGTGATATTGCCACATGTAGAT
TTAAAGCCGGTTCAAACTGTGCTGAAGGACCATGCTGCGAAAACTGTCTATTTATGTCAAAAGAAAGAATGTGTAGGCCTTCCTTTGAAG
AATGCGACCTCCCTGAATATTGCAATGGATCATCTGCATCATGCCCAGAAAACCACTATGTTCAGACTGGGCATCCGTGTGGACTGAATC
AATGGATCTGTATAGATGGAGTTTGTATGAGTGGGGATAAACAATGTACAGACACATTTGGCAAAGAAGTAGAGTTTGGCCCTTCAGAAT
GTTATTCTCACCTTAATTCAAAGACTGATGTATCTGGAAACTGTGGTATAAGTGATTCAGGATACACACAGTGTGAAGCTGATGGACATC
TCTGCATTGCTGTGGAATTTGCCAGTGATCATGCAGACAGCCAAAAGATGTGGATAAAAGATGGAACTTCTTGTGGTTCAAATAAGGTTT
GCAGGAATCAAAGATGTGTGAGTTCTTCATACTTGGGTTATGATTGTACTACTGACAAATGCAATGATAGAGGTGTATGCAATAACAAAA
AGCACTGTCACTGTAGTGCTTCATATTTACCTCCAGATTGCTCAGTTCAATCAGATCTATGGCCTGGTGGGAGTATTGACAGTGGCAATT
TTCCACCTGTAGCTATACCAGCCAGACTCCCTGAAAGGCGCTACATTGAGAACATTTACCATTCCAAACCAATGAGATGGCCATTTTTCT
TATTCATTCCTTTCTTTATTATTTTCTGTGTACTGATTGCTATAATGGTGAAAGTTAATTTCCAAAGGAAAAAATGGAGAACTGAGGACT
ATTCAAGCGATGAGCAACCTGAAAGTGAGAGTGAACCTAAAGGGTAGTCTGGACAACAGAGATGCCATGATATCACTTCTTCTAGAGTAA
TTATCTGTGATGGATGGACACAAAAAAATGGAAAGAAAAGAATGTACATTACCTGGTTTCCTGGGATTCAAACCTGCATATTGTGATTTT
AATTTGACCAGAAAATATGATATATATGTATAATTTCACAGATAATTTACTTATTTAAAAATGCATGATAATGAGTTTTACATTACAAAT
TTCTGTTTTTTTAAAGTTATCTTACGCTATTTCTGTTGGTTAGTAGACACTAATTCTGTCAGTAGGGGCATGGTATAAGGAAATATCATA

>36428_36428_3_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000541063_ADAM2_chr8_39627094_ENST00000379853_length(amino acids)=314AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVC
RNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFL

--------------------------------------------------------------
>36428_36428_4_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000541063_ADAM2_chr8_39627094_ENST00000521880_length(transcript)=1452nt_BP=397nt
CGGTCGCCCAGACATGGCGGACGGCAGCGGCTGGCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACT
GGAGGACAAGGGCAGGATTCTGGGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCC
AAGATGCTTTGCCAGATGGACAATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGAT
GACAAACTGATTATGGTGTGGAAGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAG
TGGCGGTGTGTCTCTATCCTCCGGAATCATTCAGGCGTCATTTCAGTGGTGTGAAGATCTTTAGTAACTGCAGCTTCGAAGACTTTGCAC
ATTTTATTTCAAAGCAGAAGTCCCAGTGTCTTCACAATCAGCCTCGCTTAGATCCTTTTTTCAAACAGCAAGCAGTGTGTGGTAATGCAA
AGCTGGAAGCAGGAGAGGAGTGTGACTGTGGGACTGAACAGGATTGTGCCCTTATTGGAGAAACATGCTGTGATATTGCCACATGTAGAT
TTAAAGCCGGTTCAAACTGTGCTGAAGGACCATGCTGCGAAAACTGTCTATTTATGTCAAAAGAAAGAATGTGTAGGCCTTCCTTTGAAG
AATGCGACCTCCCTGAATATTGCAATGGATCATCTGCATCATGCCCAGAAAACCACTATGTTCAGACTGGGCATCCGTGTGGACTGAATC
AATGGATCTGTATAGATGGAGTTTGTATGAGTGGGGATAAACAATGTACAGACACATTTGGCAAAGAAGTAGAGTTTGGCCCTTCAGAAT
GTTATTCTCACCTTAATTCAAAGACTGATGTATCTGGAAACTGTGGTATAAGTGATTCAGGATACACACAGTGTGAAGTTTGCAGGAATC
AAAGATGTGTGAGTTCTTCATACTTGGGTTATGATTGTACTACTGACAAATGCAATGATAGAGGTGTATGCAATAACAAAAAGCACTGTC
ACTGTAGTGCTTCATATTTACCTCCAGATTGCTCAGTTCAATCAGATCTATGGCCTGGTGGGAGTATTGACAGTGGCAATTTTCCACCTG
TAGCTATACCAGCCAGACTCCCTGAAAGGCGCTACATTGAGAACATTTACCATTCCAAACCAATGAGATGGCCATTTTTCTTATTCATTC
CTTTCTTTATTATTTTCTGTGTACTGATTGCTATAATGGTGAAAGTTAATTTCCAAAGGAAAAAATGGAGAACTGAGGACTATTCAAGCG
ATGAGCAACCTGAAAGTGAGAGTGAACCTAAAGGGTAGTCTGGACAACAGAGATGCCATGATATCACTTCTTCTAGAGTAATTATCTGTG

>36428_36428_4_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000541063_ADAM2_chr8_39627094_ENST00000521880_length(amino acids)=281AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCH
CSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSD

--------------------------------------------------------------
>36428_36428_5_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000546308_ADAM2_chr8_39627094_ENST00000265708_length(transcript)=2095nt_BP=555nt
GACATGGCGGACGGCAGCGGCTGGCAGCCGCCGCGCCCCTGCGAGGCCTACCGCGCCGAGTGGAAGCTCTGCCGCAGCGCCAGGCACTTC
CTACACCACTACTACGTCCACGGCGAGCGGCCGGCCTGCGAACAGTGGCAGCGCGACCTGGCCAGCTGCCGCGACTGGGAGGAGCGCCGG
AACGCCGAGGCCCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACTGGAGGACAAGGGCAGGATTCTG
GGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCCAAGATGCTTTGCCAGATGGACA
ATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGATGACAAACTGATTATGGTGTGGA
AGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAGTGGCGGTGTGTCTCTATCCTCC
GGAATCATTCAGGCGTCATTTCAGTGGTGTGAAGATCTTTAGTAACTGCAGCTTCGAAGACTTTGCACATTTTATTTCAAAGCAGAAGTC
CCAGTGTCTTCACAATCAGCCTCGCTTAGATCCTTTTTTCAAACAGCAAGCAGTGTGTGGTAATGCAAAGCTGGAAGCAGGAGAGGAGTG
TGACTGTGGGACTGAACAGGATTGTGCCCTTATTGGAGAAACATGCTGTGATATTGCCACATGTAGATTTAAAGCCGGTTCAAACTGTGC
TGAAGGACCATGCTGCGAAAACTGTCTATTTATGTCAAAAGAAAGAATGTGTAGGCCTTCCTTTGAAGAATGCGACCTCCCTGAATATTG
CAATGGATCATCTGCATCATGCCCAGAAAACCACTATGTTCAGACTGGGCATCCGTGTGGACTGAATCAATGGATCTGTATAGATGGAGT
TTGTATGAGTGGGGATAAACAATGTACAGACACATTTGGCAAAGAAGTAGAGTTTGGCCCTTCAGAATGTTATTCTCACCTTAATTCAAA
GACTGATGTATCTGGAAACTGTGGTATAAGTGATTCAGGATACACACAGTGTGAAGCTGACAATCTGCAGTGCGGAAAATTAATATGTAA
ATATGTAGGTAAATTTTTATTACAAATTCCAAGAGCCACTATTATTTATGCCAACATAAGTGGACATCTCTGCATTGCTGTGGAATTTGC
CAGTGATCATGCAGACAGCCAAAAGATGTGGATAAAAGATGGAACTTCTTGTGGTTCAAATAAGGTTTGCAGGAATCAAAGATGTGTGAG
TTCTTCATACTTGGGTTATGATTGTACTACTGACAAATGCAATGATAGAGGTGTATGCAATAACAAAAAGCACTGTCACTGTAGTGCTTC
ATATTTACCTCCAGATTGCTCAGTTCAATCAGATCTATGGCCTGGTGGGAGTATTGACAGTGGCAATTTTCCACCTGTAGCTATACCAGC
CAGACTCCCTGAAAGGCGCTACATTGAGAACATTTACCATTCCAAACCAATGAGATGGCCATTTTTCTTATTCATTCCTTTCTTTATTAT
TTTCTGTGTACTGATTGCTATAATGGTGAAAGTTAATTTCCAAAGGAAAAAATGGAGAACTGAGGACTATTCAAGCGATGAGCAACCTGA
AAGTGAGAGTGAACCTAAAGGGTAGTCTGGACAACAGAGATGCCATGATATCACTTCTTCTAGAGTAATTATCTGTGATGGATGGACACA
AAAAAATGGAAAGAAAAGAATGTACATTACCTGGTTTCCTGGGATTCAAACCTGCATATTGTGATTTTAATTTGACCAGAAAATATGATA
TATATGTATAATTTCACAGATAATTTACTTATTTAAAAATGCATGATAATGAGTTTTACATTACAAATTTCTGTTTTTTTAAAGTTATCT
TACGCTATTTCTGTTGGTTAGTAGACACTAATTCTGTCAGTAGGGGCATGGTATAAGGAAATATCATAATGTAATGAGGTGGTACTATGA

>36428_36428_5_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000546308_ADAM2_chr8_39627094_ENST00000265708_length(amino acids)=344AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHL
CIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNF

--------------------------------------------------------------
>36428_36428_6_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000546308_ADAM2_chr8_39627094_ENST00000347580_length(transcript)=2095nt_BP=555nt
GACATGGCGGACGGCAGCGGCTGGCAGCCGCCGCGCCCCTGCGAGGCCTACCGCGCCGAGTGGAAGCTCTGCCGCAGCGCCAGGCACTTC
CTACACCACTACTACGTCCACGGCGAGCGGCCGGCCTGCGAACAGTGGCAGCGCGACCTGGCCAGCTGCCGCGACTGGGAGGAGCGCCGG
AACGCCGAGGCCCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACTGGAGGACAAGGGCAGGATTCTG
GGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCCAAGATGCTTTGCCAGATGGACA
ATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGATGACAAACTGATTATGGTGTGGA
AGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAGTGGCGGTGTGTCTCTATCCTCC
GGAATCATTCAGGCGTCATTTCAGTGGTGTGAAGATCTTTAGTAACTGCAGCTTCGAAGACTTTGCACATTTTATTTCAAAGCAGAAGTC
CCAGTGTCTTCACAATCAGCCTCGCTTAGATCCTTTTTTCAAACAGCAAGCAGTGTGTGGTAATGCAAAGCTGGAAGCAGGAGAGGAGTG
TGACTGTGGGACTGAACAGGATTGTGCCCTTATTGGAGAAACATGCTGTGATATTGCCACATGTAGATTTAAAGCCGGTTCAAACTGTGC
TGAAGGACCATGCTGCGAAAACTGTCTATTTATGTCAAAAGAAAGAATGTGTAGGCCTTCCTTTGAAGAATGCGACCTCCCTGAATATTG
CAATGGATCATCTGCATCATGCCCAGAAAACCACTATGTTCAGACTGGGCATCCGTGTGGACTGAATCAATGGATCTGTATAGATGGAGT
TTGTATGAGTGGGGATAAACAATGTACAGACACATTTGGCAAAGAAGTAGAGTTTGGCCCTTCAGAATGTTATTCTCACCTTAATTCAAA
GACTGATGTATCTGGAAACTGTGGTATAAGTGATTCAGGATACACACAGTGTGAAGCTGACAATCTGCAGTGCGGAAAATTAATATGTAA
ATATGTAGGTAAATTTTTATTACAAATTCCAAGAGCCACTATTATTTATGCCAACATAAGTGGACATCTCTGCATTGCTGTGGAATTTGC
CAGTGATCATGCAGACAGCCAAAAGATGTGGATAAAAGATGGAACTTCTTGTGGTTCAAATAAGGTTTGCAGGAATCAAAGATGTGTGAG
TTCTTCATACTTGGGTTATGATTGTACTACTGACAAATGCAATGATAGAGGTGTATGCAATAACAAAAAGCACTGTCACTGTAGTGCTTC
ATATTTACCTCCAGATTGCTCAGTTCAATCAGATCTATGGCCTGGTGGGAGTATTGACAGTGGCAATTTTCCACCTGTAGCTATACCAGC
CAGACTCCCTGAAAGGCGCTACATTGAGAACATTTACCATTCCAAACCAATGAGATGGCCATTTTTCTTATTCATTCCTTTCTTTATTAT
TTTCTGTGTACTGATTGCTATAATGGTGAAAGTTAATTTCCAAAGGAAAAAATGGAGAACTGAGGACTATTCAAGCGATGAGCAACCTGA
AAGTGAGAGTGAACCTAAAGGGTAGTCTGGACAACAGAGATGCCATGATATCACTTCTTCTAGAGTAATTATCTGTGATGGATGGACACA
AAAAAATGGAAAGAAAAGAATGTACATTACCTGGTTTCCTGGGATTCAAACCTGCATATTGTGATTTTAATTTGACCAGAAAATATGATA
TATATGTATAATTTCACAGATAATTTACTTATTTAAAAATGCATGATAATGAGTTTTACATTACAAATTTCTGTTTTTTTAAAGTTATCT
TACGCTATTTCTGTTGGTTAGTAGACACTAATTCTGTCAGTAGGGGCATGGTATAAGGAAATATCATAATGTAATGAGGTGGTACTATGA

>36428_36428_6_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000546308_ADAM2_chr8_39627094_ENST00000347580_length(amino acids)=344AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHL
CIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNF

--------------------------------------------------------------
>36428_36428_7_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000546308_ADAM2_chr8_39627094_ENST00000379853_length(transcript)=2005nt_BP=555nt
GACATGGCGGACGGCAGCGGCTGGCAGCCGCCGCGCCCCTGCGAGGCCTACCGCGCCGAGTGGAAGCTCTGCCGCAGCGCCAGGCACTTC
CTACACCACTACTACGTCCACGGCGAGCGGCCGGCCTGCGAACAGTGGCAGCGCGACCTGGCCAGCTGCCGCGACTGGGAGGAGCGCCGG
AACGCCGAGGCCCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACTGGAGGACAAGGGCAGGATTCTG
GGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCCAAGATGCTTTGCCAGATGGACA
ATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGATGACAAACTGATTATGGTGTGGA
AGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAGTGGCGGTGTGTCTCTATCCTCC
GGAATCATTCAGGCGTCATTTCAGTGGTGTGAAGATCTTTAGTAACTGCAGCTTCGAAGACTTTGCACATTTTATTTCAAAGCAGAAGTC
CCAGTGTCTTCACAATCAGCCTCGCTTAGATCCTTTTTTCAAACAGCAAGCAGTGTGTGGTAATGCAAAGCTGGAAGCAGGAGAGGAGTG
TGACTGTGGGACTGAACAGGATTGTGCCCTTATTGGAGAAACATGCTGTGATATTGCCACATGTAGATTTAAAGCCGGTTCAAACTGTGC
TGAAGGACCATGCTGCGAAAACTGTCTATTTATGTCAAAAGAAAGAATGTGTAGGCCTTCCTTTGAAGAATGCGACCTCCCTGAATATTG
CAATGGATCATCTGCATCATGCCCAGAAAACCACTATGTTCAGACTGGGCATCCGTGTGGACTGAATCAATGGATCTGTATAGATGGAGT
TTGTATGAGTGGGGATAAACAATGTACAGACACATTTGGCAAAGAAGTAGAGTTTGGCCCTTCAGAATGTTATTCTCACCTTAATTCAAA
GACTGATGTATCTGGAAACTGTGGTATAAGTGATTCAGGATACACACAGTGTGAAGCTGATGGACATCTCTGCATTGCTGTGGAATTTGC
CAGTGATCATGCAGACAGCCAAAAGATGTGGATAAAAGATGGAACTTCTTGTGGTTCAAATAAGGTTTGCAGGAATCAAAGATGTGTGAG
TTCTTCATACTTGGGTTATGATTGTACTACTGACAAATGCAATGATAGAGGTGTATGCAATAACAAAAAGCACTGTCACTGTAGTGCTTC
ATATTTACCTCCAGATTGCTCAGTTCAATCAGATCTATGGCCTGGTGGGAGTATTGACAGTGGCAATTTTCCACCTGTAGCTATACCAGC
CAGACTCCCTGAAAGGCGCTACATTGAGAACATTTACCATTCCAAACCAATGAGATGGCCATTTTTCTTATTCATTCCTTTCTTTATTAT
TTTCTGTGTACTGATTGCTATAATGGTGAAAGTTAATTTCCAAAGGAAAAAATGGAGAACTGAGGACTATTCAAGCGATGAGCAACCTGA
AAGTGAGAGTGAACCTAAAGGGTAGTCTGGACAACAGAGATGCCATGATATCACTTCTTCTAGAGTAATTATCTGTGATGGATGGACACA
AAAAAATGGAAAGAAAAGAATGTACATTACCTGGTTTCCTGGGATTCAAACCTGCATATTGTGATTTTAATTTGACCAGAAAATATGATA
TATATGTATAATTTCACAGATAATTTACTTATTTAAAAATGCATGATAATGAGTTTTACATTACAAATTTCTGTTTTTTTAAAGTTATCT
TACGCTATTTCTGTTGGTTAGTAGACACTAATTCTGTCAGTAGGGGCATGGTATAAGGAAATATCATAATGTAATGAGGTGGTACTATGA

>36428_36428_7_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000546308_ADAM2_chr8_39627094_ENST00000379853_length(amino acids)=314AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVC
RNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFL

--------------------------------------------------------------
>36428_36428_8_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000546308_ADAM2_chr8_39627094_ENST00000521880_length(transcript)=1610nt_BP=555nt
GACATGGCGGACGGCAGCGGCTGGCAGCCGCCGCGCCCCTGCGAGGCCTACCGCGCCGAGTGGAAGCTCTGCCGCAGCGCCAGGCACTTC
CTACACCACTACTACGTCCACGGCGAGCGGCCGGCCTGCGAACAGTGGCAGCGCGACCTGGCCAGCTGCCGCGACTGGGAGGAGCGCCGG
AACGCCGAGGCCCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACTGGAGGACAAGGGCAGGATTCTG
GGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCCAAGATGCTTTGCCAGATGGACA
ATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGATGACAAACTGATTATGGTGTGGA
AGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAGTGGCGGTGTGTCTCTATCCTCC
GGAATCATTCAGGCGTCATTTCAGTGGTGTGAAGATCTTTAGTAACTGCAGCTTCGAAGACTTTGCACATTTTATTTCAAAGCAGAAGTC
CCAGTGTCTTCACAATCAGCCTCGCTTAGATCCTTTTTTCAAACAGCAAGCAGTGTGTGGTAATGCAAAGCTGGAAGCAGGAGAGGAGTG
TGACTGTGGGACTGAACAGGATTGTGCCCTTATTGGAGAAACATGCTGTGATATTGCCACATGTAGATTTAAAGCCGGTTCAAACTGTGC
TGAAGGACCATGCTGCGAAAACTGTCTATTTATGTCAAAAGAAAGAATGTGTAGGCCTTCCTTTGAAGAATGCGACCTCCCTGAATATTG
CAATGGATCATCTGCATCATGCCCAGAAAACCACTATGTTCAGACTGGGCATCCGTGTGGACTGAATCAATGGATCTGTATAGATGGAGT
TTGTATGAGTGGGGATAAACAATGTACAGACACATTTGGCAAAGAAGTAGAGTTTGGCCCTTCAGAATGTTATTCTCACCTTAATTCAAA
GACTGATGTATCTGGAAACTGTGGTATAAGTGATTCAGGATACACACAGTGTGAAGTTTGCAGGAATCAAAGATGTGTGAGTTCTTCATA
CTTGGGTTATGATTGTACTACTGACAAATGCAATGATAGAGGTGTATGCAATAACAAAAAGCACTGTCACTGTAGTGCTTCATATTTACC
TCCAGATTGCTCAGTTCAATCAGATCTATGGCCTGGTGGGAGTATTGACAGTGGCAATTTTCCACCTGTAGCTATACCAGCCAGACTCCC
TGAAAGGCGCTACATTGAGAACATTTACCATTCCAAACCAATGAGATGGCCATTTTTCTTATTCATTCCTTTCTTTATTATTTTCTGTGT
ACTGATTGCTATAATGGTGAAAGTTAATTTCCAAAGGAAAAAATGGAGAACTGAGGACTATTCAAGCGATGAGCAACCTGAAAGTGAGAG

>36428_36428_8_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000546308_ADAM2_chr8_39627094_ENST00000521880_length(amino acids)=281AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCH
CSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HIRA-ADAM2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000263208	-	5	25	421_479	132.33333333333334	1018.0	ASF1A
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000340170	-	5	21	421_479	132.33333333333334	811.0	ASF1A
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000263208	-	5	25	421_729	132.33333333333334	1018.0	CCNA1
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000340170	-	5	21	421_729	132.33333333333334	811.0	CCNA1
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000263208	-	5	25	593_826	132.33333333333334	1018.0	histone H2B
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000340170	-	5	21	593_826	132.33333333333334	811.0	histone H2B
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000263208	-	5	25	738_1017	132.33333333333334	1018.0	histone H4
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000340170	-	5	21	738_1017	132.33333333333334	811.0	histone H4
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000263208	-	5	25	594_739	132.33333333333334	1018.0	PAX3
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000263208	-	5	25	740_828	132.33333333333334	1018.0	PAX3
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000340170	-	5	21	594_739	132.33333333333334	811.0	PAX3
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000340170	-	5	21	740_828	132.33333333333334	811.0	PAX3

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for HIRA-ADAM2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for HIRA-ADAM2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source