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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:HIRA-CABIN1 (FusionGDB2 ID:36430)

Fusion Gene Summary for HIRA-CABIN1

Fusion gene summary

Fusion gene information	Fusion gene name: HIRA-CABIN1
	Fusion gene ID: 36430
		Hgene	Tgene
	Gene symbol	HIRA	CABIN1
	Gene ID	7290	23523
	Gene name	histone cell cycle regulator	calcineurin binding protein 1
	Synonyms	DGCR1\|TUP1\|TUPLE1	CAIN\|KB-318B8.7\|PPP3IN
	Cytomap	22q11.21	22q11.23
	Type of gene	protein-coding	protein-coding
	Description	protein HIRADiGeorge critical region gene 1HIR histone cell cycle regulation defective homolog ATUP1-like enhancer of split protein 1histone regulator A	calcineurin-binding protein cabin-1calcineurin binding protein cabin 1calcineurin inhibitor
	Modification date	20200313	20200313
	UniProtAcc	P54198	Q9Y6J0
	Ensembl transtripts involved in fusion gene	ENST00000263208, ENST00000340170, ENST00000541063, ENST00000546308, ENST00000464189,	ENST00000485008, ENST00000263119, ENST00000337989, ENST00000398319, ENST00000405822,
Fusion gene scores	* DoF score	18 X 15 X 9=2430	13 X 11 X 7=1001
	# samples	23	15
	** MAII score	log2(23/2430*10)=-3.40125054754877 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1001*10)=-2.73840756834011 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HIRA [Title/Abstract] AND CABIN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HIRA(19371143)-CABIN1(24560368), # samples:3
Anticipated loss of major functional domain due to fusion event.	HIRA-CABIN1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. HIRA-CABIN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. HIRA-CABIN1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. HIRA-CABIN1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HIRA	GO:0006336	DNA replication-independent nucleosome assembly	14718166
Tgene	CABIN1	GO:0006336	DNA replication-independent nucleosome assembly	14718166

Fusion gene breakpoints across HIRA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CABIN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A0AU-01A	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+

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Fusion Gene ORF analysis for HIRA-CABIN1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000263208	ENST00000485008	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
5CDS-intron	ENST00000340170	ENST00000485008	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
5CDS-intron	ENST00000541063	ENST00000485008	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
5CDS-intron	ENST00000546308	ENST00000485008	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
Frame-shift	ENST00000263208	ENST00000263119	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
Frame-shift	ENST00000263208	ENST00000337989	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
Frame-shift	ENST00000263208	ENST00000398319	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
Frame-shift	ENST00000263208	ENST00000405822	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
Frame-shift	ENST00000340170	ENST00000263119	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
Frame-shift	ENST00000340170	ENST00000337989	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
Frame-shift	ENST00000340170	ENST00000398319	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
Frame-shift	ENST00000340170	ENST00000405822	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
Frame-shift	ENST00000546308	ENST00000263119	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
Frame-shift	ENST00000546308	ENST00000337989	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
Frame-shift	ENST00000546308	ENST00000398319	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
Frame-shift	ENST00000546308	ENST00000405822	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
In-frame	ENST00000541063	ENST00000263119	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
In-frame	ENST00000541063	ENST00000337989	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
In-frame	ENST00000541063	ENST00000398319	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
In-frame	ENST00000541063	ENST00000405822	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
intron-3CDS	ENST00000464189	ENST00000263119	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
intron-3CDS	ENST00000464189	ENST00000337989	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
intron-3CDS	ENST00000464189	ENST00000398319	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
intron-3CDS	ENST00000464189	ENST00000405822	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+
intron-intron	ENST00000464189	ENST00000485008	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000541063	HIRA	chr22	19371143	-	ENST00000263119	CABIN1	chr22	24560368	+	3764	1415	1391	3331	646
ENST00000541063	HIRA	chr22	19371143	-	ENST00000405822	CABIN1	chr22	24560368	+	3764	1415	1391	3331	646
ENST00000541063	HIRA	chr22	19371143	-	ENST00000398319	CABIN1	chr22	24560368	+	3764	1415	1391	3331	646
ENST00000541063	HIRA	chr22	19371143	-	ENST00000337989	CABIN1	chr22	24560368	+	3598	1415	1391	3166	591

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000541063	ENST00000263119	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+	0.023976881	0.9760231
ENST00000541063	ENST00000405822	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+	0.023976881	0.9760231
ENST00000541063	ENST00000398319	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+	0.023976881	0.9760231
ENST00000541063	ENST00000337989	HIRA	chr22	19371143	-	CABIN1	chr22	24560368	+	0.02377536	0.9762247

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Fusion Genomic Features for HIRA-CABIN1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HIRA	chr22	19371142	-	CABIN1	chr22	24560367	+	3.59E-06	0.9999964
HIRA	chr22	19371142	-	CABIN1	chr22	24560367	+	3.59E-06	0.9999964

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HIRA-CABIN1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:19371143/chr22:24560368)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HIRA P54198	CABIN1 Q9Y6J0
FUNCTION: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269\|PubMed:12370293, ECO:0000269\|PubMed:14718166, ECO:0000269\|PubMed:15621527}.	FUNCTION: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269\|PubMed:14718166, ECO:0000269\|PubMed:9655484}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000263208

408_412

471

1018.0

Compositional bias

Note=Poly-Gln

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000340170

408_412

471

811.0

Compositional bias

Note=Poly-Gln

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000263208

11_53

471

1018.0

Repeat

Note=WD 1

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000263208

129_168

471

1018.0

Repeat

Note=WD 3

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000263208

172_211

471

1018.0

Repeat

Note=WD 4

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000263208

220_263

471

1018.0

Repeat

Note=WD 5

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000263208

266_322

471

1018.0

Repeat

Note=WD 6

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000263208

326_367

471

1018.0

Repeat

Note=WD 7

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000263208

68_107

471

1018.0

Repeat

Note=WD 2

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000340170

11_53

471

811.0

Repeat

Note=WD 1

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000340170

129_168

471

811.0

Repeat

Note=WD 3

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000340170

172_211

471

811.0

Repeat

Note=WD 4

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000340170

220_263

471

811.0

Repeat

Note=WD 5

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000340170

266_322

471

811.0

Repeat

Note=WD 6

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000340170

326_367

471

811.0

Repeat

Note=WD 7

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000340170

68_107

471

811.0

Repeat

Note=WD 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000263208

640_643

471

1018.0

Compositional bias

Note=Poly-Lys

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000263208

805_808

471

1018.0

Compositional bias

Note=Poly-Val

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000340170

640_643

471

811.0

Compositional bias

Note=Poly-Lys

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000340170

805_808

471

811.0

Compositional bias

Note=Poly-Val

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000263208

439_475

471

1018.0

Region

Note=Required for repression of histone gene transcription

Hgene

HIRA

chr22:19371143

chr22:24560368

ENST00000340170

439_475

471

811.0

Region

Note=Required for repression of histone gene transcription

Tgene

CABIN1

chr22:19371143

chr22:24560368

ENST00000263119

1055_1088

1582

2221.0

Repeat

Note=TPR 5

Tgene

CABIN1

chr22:19371143

chr22:24560368

ENST00000263119

1106_1139

1582

2221.0

Repeat

Note=TPR 6

Tgene

CABIN1

chr22:19371143

chr22:24560368

ENST00000263119

125_157

1582

2221.0

Repeat

Note=TPR 3

Tgene

CABIN1

chr22:19371143

chr22:24560368

ENST00000263119

36_69

1582

2221.0

Repeat

Note=TPR 1

Tgene

CABIN1

chr22:19371143

chr22:24560368

ENST00000263119

615_648

1582

2221.0

Repeat

Note=TPR 4

Tgene

CABIN1

chr22:19371143

chr22:24560368

ENST00000263119

90_123

1582

2221.0

Repeat

Note=TPR 2

Tgene

CABIN1

chr22:19371143

chr22:24560368

ENST00000398319

1055_1088

1582

2221.0

Repeat

Note=TPR 5

Tgene

CABIN1

chr22:19371143

chr22:24560368

ENST00000398319

1106_1139

1582

2221.0

Repeat

Note=TPR 6

Tgene

CABIN1

chr22:19371143

chr22:24560368

ENST00000398319

125_157

1582

2221.0

Repeat

Note=TPR 3

Tgene

CABIN1

chr22:19371143

chr22:24560368

ENST00000398319

36_69

1582

2221.0

Repeat

Note=TPR 1

Tgene

CABIN1

chr22:19371143

chr22:24560368

ENST00000398319

615_648

1582

2221.0

Repeat

Note=TPR 4

Tgene

CABIN1

chr22:19371143

chr22:24560368

ENST00000398319

90_123

1582

2221.0

Repeat

Note=TPR 2

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Fusion Gene Sequence for HIRA-CABIN1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>36430_36430_1_HIRA-CABIN1_HIRA_chr22_19371143_ENST00000541063_CABIN1_chr22_24560368_ENST00000263119_length(transcript)=3764nt_BP=1415nt
CGGTCGCCCAGACATGGCGGACGGCAGCGGCTGGCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACT
GGAGGACAAGGGCAGGATTCTGGGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCC
AAGATGCTTTGCCAGATGGACAATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGAT
GACAAACTGATTATGGTGTGGAAGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAG
TGGCGGTGTGTCTCTATCCTCCGGAATCATTCAGGCGATGTGATGGATGTAGCATGGTCTCCCCACGATGCCTGGCTAGCCTCATGCAGC
GTGGATAACACTGTCGTCATCTGGAATGCTGTAAAGTTCCCAGAAATTCTAGCTACTCTGAGAGGTCATTCTGGCTTGGTCAAAGGGTTG
ACATGGGACCCTGTTGGTAAATACATAGCTTCTCAAGCTGATGACCGCAGCCTAAAGGTGTGGAGGACGCTGGACTGGCAGTTGGAGACC
AGCATCACCAAGCCTTTTGATGAGTGTGGAGGAACGACCCATGTGTTGCGGCTCAGCTGGTCACCTGATGGGCATTACCTGGTGTCTGCC
CATGCCATGAACAACTCAGGCCCCACTGCCCAGATCATCGAACGGGAGGGATGGAAGACCAACATGGACTTTGTTGGGCACCGGAAAGCT
GTGACTGTCGTGAAATTCAACCCAAAAATCTTCAAAAAGAAGCAGAAGAATGGGAGTTCTGCGAAGCCTAGCTGCCCGTACTGCTGCTGT
GCTGTTGGCAGCAAGGACCGCTCGCTTTCTGTCTGGCTCACATGTCTGAAACGGCCGCTGGTGGTCATCCATGAACTGTTTGACAAATCC
ATCATGGATATTTCCTGGACTCTGAATGGGCTGGGCATCTTGGTATGCTCTATGGACGGCTCTGTGGCATTCCTCGACTTCTCCCAGGAT
GAGCTTGGCGATCCCCTGAGCGAGGAGGAGAAGAGCCGCATTCACCAGTCCACCTATGGCAAGAGCCTAGCCATCATGACCGAGGCCCAG
CTCTCCACAGCCGTCATTGAGAACCCTGAGATGCTCAAGTACCAGCGAAGGCAGCAGCAGCAGCAGCTGGACCAGAAGAGTGCTGCGACC
AGGGAGATGGGCTCAGCCACCTCAGTCGCAGGCGTTGTCAACGGGGAGAGTCTTGAAGATATCAGGAAGAATCTTTTGAAGAAACAAGTT
GAGACTCGGACAGCAGATGGCCGGAGAAGAATCACGCCTCTCTGCATAGCACAGCTGGACACTGGGGCATCTGGCGGATCCCCGTGGACG
AGATTGACCGGCCGGGCAGCTTTGCCTGGCACATGAACCGCTCCATCGTGCTGCTGCTCAAGGTGCTGGCCCAGCTGCGGGACCACAGCA
CCCTGCTGAAGGTGTCCTCCATGCTTCAGCGGACCCCAGACCAGGGCAAGAAGTATCTGCGAGATGCTGACCGCCAGGTCCTGGCGCAGC
GGGCCTTCATCCTCACTGTGAAGGTGCTCGAAGACACGCTGAGCGAGCTCGCAGAGGGGTCAGAACGCCCAGGGCCCAAGGTCTGTGGCC
TCCCCGGAGCCAGGATGACCACCGATGTCTCACACAAGGCCAGTCCTGAGGATGGCCAGGAGGGCCTCCCCCAGCCGAAGAAGCCCCCTC
TGGCTGATGGCTCAGGGCCAGGGCCCGAGCCAGGAGGCAAAGTGGGCCTCCTCAACCACCGGCCTGTGGCCATGGATGCAGGAGACAGTG
CAGACCAAAGCGGGGAGCGGAAGGATAAAGAGAGCCCACGGGCAGGGCCCACTGAGCCCATGGACACGAGTGAGGCCACTGTTTGCCACT
CAGACTTGGAGCGGACACCACCCCTGCTGCCAGGTCGCCCCGCAAGGGACCGGGGCCCCGAGAGCCGGCCCACTGAGCTGTCCCTGGAGG
AGCTGAGCATCAGTGCCCGGCAGCAGCCCACCCCGCTCACCCCAGCCCAGCCAGCCCCCGCCCCCGCCCCCGCCACCACCACAGGGACCA
GGGCAGGGGGCCACCCGGAGGAGCCGCTCTCCCGGCTCAGCCGCAAGAGGAAGCTCCTGGAGGACACAGAGTCAGGCAAGACACTTCTGT
TGGATGCCTACCGTGTGTGGCAGCAGGGCCAGAAGGGTGTGGCCTATGACCTGGGCCGTGTGGAGAGGATCATGTCGGAGACCTACATGC
TCATCAAGCAGGTGGATGAGGAGGCTGCGCTGGAGCAGGCTGTGAAGTTCTGCCAGGTCCATCTTGGGGCTGCCGCCCAGAGACAGGCCT
CGGGGGACACCCCCACCACTCCAAAGCACCCCAAAGACAGCCGAGAGAACTTCTTTCCTGTGACAGTGGTGCCCACAGCCCCTGACCCTG
TGCCAGCTGACTCTGTCCAGCGGCCCAGTGATGCTCACACCAAGCCTCGCCCTGCACTAGCTGCCGCCACAACTATTATCACCTGCCCTC
CGTCAGCATCAGCTTCCACCCTGGACCAGTCCAAGGACCCTGGGCCTCCCCGGCCACACAGGCCTGAAGCTACCCCCAGCATGGCCTCTC
TGGGCCCAGAGGGAGAAGAGCTGGCGAGAGTGGCAGAGGGCACCAGCTTCCCGCCTCAGGAGCCACGGCACAGTCCGCAGGTGAAGATGG
CCCCCACAAGTTCCCCGGCAGAGCCACACTGCTGGCCGGCAGAGGCTGCCCTGGGCACAGGCGCTGAGCCCACCTGCAGCCAGGAGGGGA
AACTGAGGCCTGAGCCGAGAAGGGATGGGGAGGCTCAGGAGGCTGCGAGTGAGACTCAGCCCCTGAGCTCTCCCCCAACAGCTGCCAGCT
CCAAGGCCCCCAGCAGTGGGAGTGCCCAGCCACCAGAGGGTCACCCAGGCAAGCCTGAGCCCAGCCGGGCTAAGTCCCGCCCCCTGCCCA
ACATGCCAAAGCTGGTCATCCCCTCCGCCGCCACCAAGTTCCCCCCTGAGATCACCGTCACGCCACCCACCCCAACCCTGCTCTCCCCCA
AAGGCAGCATCTCGGAGGAGACCAAGCAGAAGCTGAAGTCAGCCATCCTTTCTGCCCAGTCTGCTGCCAACGTGAGGAAGGAGAGCCTAT
GCCAGCCAGCCCTGGAGGTCCTGGAGACATCCAGCCAGGAGTCCTCGCTGGAGAGCGAGACAGACGAGGACGACGACTACATGGACATTT
GAGGGGCCACTGCAGCCCCACCGCCACGCCCCAGGGGACCAGCCAGGCCTGGAATGCCCCCTGGGCAGGACCCTGGGCAGGACCAGAGGC
CCACATGGATGCCACTCCCCACACAGCCCCCAGGCCTGCCCAGCCCACCTCCTCATGGCATCCTCCCTGTACCCAGGTCAGGCTGTCCAC
ACCACATGGGAGCCCAGAGGAGGAGGGGCCCGCCTTAGCCATGTGAAGGTGGATTGGTCGCCATCTGCACGCCAGGCGGCATCCTTTTCT
ATGAAGTGTTGACTTTGTAAATCTGCCCACACCCAGCTGGCCATATCCACCCCTCGACGCCGGGATGAGCCGGCTCTGCCTGTGTCACAG

>36430_36430_1_HIRA-CABIN1_HIRA_chr22_19371143_ENST00000541063_CABIN1_chr22_24560368_ENST00000263119_length(amino acids)=646AA_BP=8
MHSTAGHWGIWRIPVDEIDRPGSFAWHMNRSIVLLLKVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTL
SELAEGSERPGPKVCGLPGARMTTDVSHKASPEDGQEGLPQPKKPPLADGSGPGPEPGGKVGLLNHRPVAMDAGDSADQSGERKDKESPR
AGPTEPMDTSEATVCHSDLERTPPLLPGRPARDRGPESRPTELSLEELSISARQQPTPLTPAQPAPAPAPATTTGTRAGGHPEEPLSRLS
RKRKLLEDTESGKTLLLDAYRVWQQGQKGVAYDLGRVERIMSETYMLIKQVDEEAALEQAVKFCQVHLGAAAQRQASGDTPTTPKHPKDS
RENFFPVTVVPTAPDPVPADSVQRPSDAHTKPRPALAAATTIITCPPSASASTLDQSKDPGPPRPHRPEATPSMASLGPEGEELARVAEG
TSFPPQEPRHSPQVKMAPTSSPAEPHCWPAEAALGTGAEPTCSQEGKLRPEPRRDGEAQEAASETQPLSSPPTAASSKAPSSGSAQPPEG
HPGKPEPSRAKSRPLPNMPKLVIPSAATKFPPEITVTPPTPTLLSPKGSISEETKQKLKSAILSAQSAANVRKESLCQPALEVLETSSQE

--------------------------------------------------------------
>36430_36430_2_HIRA-CABIN1_HIRA_chr22_19371143_ENST00000541063_CABIN1_chr22_24560368_ENST00000337989_length(transcript)=3598nt_BP=1415nt
CGGTCGCCCAGACATGGCGGACGGCAGCGGCTGGCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACT
GGAGGACAAGGGCAGGATTCTGGGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCC
AAGATGCTTTGCCAGATGGACAATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGAT
GACAAACTGATTATGGTGTGGAAGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAG
TGGCGGTGTGTCTCTATCCTCCGGAATCATTCAGGCGATGTGATGGATGTAGCATGGTCTCCCCACGATGCCTGGCTAGCCTCATGCAGC
GTGGATAACACTGTCGTCATCTGGAATGCTGTAAAGTTCCCAGAAATTCTAGCTACTCTGAGAGGTCATTCTGGCTTGGTCAAAGGGTTG
ACATGGGACCCTGTTGGTAAATACATAGCTTCTCAAGCTGATGACCGCAGCCTAAAGGTGTGGAGGACGCTGGACTGGCAGTTGGAGACC
AGCATCACCAAGCCTTTTGATGAGTGTGGAGGAACGACCCATGTGTTGCGGCTCAGCTGGTCACCTGATGGGCATTACCTGGTGTCTGCC
CATGCCATGAACAACTCAGGCCCCACTGCCCAGATCATCGAACGGGAGGGATGGAAGACCAACATGGACTTTGTTGGGCACCGGAAAGCT
GTGACTGTCGTGAAATTCAACCCAAAAATCTTCAAAAAGAAGCAGAAGAATGGGAGTTCTGCGAAGCCTAGCTGCCCGTACTGCTGCTGT
GCTGTTGGCAGCAAGGACCGCTCGCTTTCTGTCTGGCTCACATGTCTGAAACGGCCGCTGGTGGTCATCCATGAACTGTTTGACAAATCC
ATCATGGATATTTCCTGGACTCTGAATGGGCTGGGCATCTTGGTATGCTCTATGGACGGCTCTGTGGCATTCCTCGACTTCTCCCAGGAT
GAGCTTGGCGATCCCCTGAGCGAGGAGGAGAAGAGCCGCATTCACCAGTCCACCTATGGCAAGAGCCTAGCCATCATGACCGAGGCCCAG
CTCTCCACAGCCGTCATTGAGAACCCTGAGATGCTCAAGTACCAGCGAAGGCAGCAGCAGCAGCAGCTGGACCAGAAGAGTGCTGCGACC
AGGGAGATGGGCTCAGCCACCTCAGTCGCAGGCGTTGTCAACGGGGAGAGTCTTGAAGATATCAGGAAGAATCTTTTGAAGAAACAAGTT
GAGACTCGGACAGCAGATGGCCGGAGAAGAATCACGCCTCTCTGCATAGCACAGCTGGACACTGGGGCATCTGGCGGATCCCCGTGGACG
AGATTGACCGGCCGGGCAGCTTTGCCTGGCACATGAACCGCTCCATCGTGCTGCTGCTCAAGGTGCTGGCCCAGCTGCGGGACCACAGCA
CCCTGCTGAAGGTGTCCTCCATGCTTCAGCGGACCCCAGACCAGGGCAAGAAGTATCTGCGAGATGCTGACCGCCAGGTCCTGGCGCAGC
GGGCCTTCATCCTCACTGTGAAGGTGCTCGAAGACACGCTGAGCGAGCTCGCAGAGGGGTCAGAACGCCCAGGGCCCAAGGTCTGTGGCC
TCCCCGGAGCCAGGATGACCACCGATGTCTCACACAAGGCCAGTCCTGAGGATGGCCAGGAGGGCCTCCCCCAGCCGAAGAAGCCCCCTC
TGGCTGATGGCTCAGGGCCAGGGCCCGAGCCAGGAGGCAAAGTGGGCCTCCTCAACCACCGGCCTGTGGCCATGGATGCAGGAGACAGTG
CAGACCAAAGCGGGGAGCGGAAGGATAAAGAGAGCCCACGGGCAGGGCCCACTGAGCCCATGGACACGAGTGAGGCCACTGTTTGCCACT
CAGACTTGGAGCGGACACCACCCCTGCTGCCAGGTCGCCCCGCAAGGGACCGGGGCCCCGAGAGCCGGCCCACTGAGCTGTCCCTGGAGG
AGCTGAGCATCAGTGCCCGGCAGCAGCCCACCCCGCTCACCCCAGCCCAGCCAGCCCCCGCCCCCGCCCCCGCCACCACCACAGGGACCA
GGGCAGGGGGCCACCCGGAGGAGCCGCTCTCCCGGCTCAGCCGCAAGAGGAAGCTCCTGGAGGACACAGAGTCAGGCAAGACACTTCTGT
TGGATGCCTACCGTGTGTGGCAGCAGGGCCAGAAGGGTGTGGCCTATGACCTGGGCCGTGTGGAGAGGATCATGTCGGAGACCTACATGC
TCATCAAGCAGGTGGATGAGGAGGCTGCGCTGGAGCAGGCTGTGAAGTTCTGCCAGGTCCATCTTGGGGCTGCCGCCCAGAGACAGGCCT
CGGGGGACACCCCCACCACTCCAAAGCACCCCAAAGACAGCCGAGAGAACTTCTTTCCTGTGACAGTGGTGCCCACAGCCCCTGACCCTG
TGCCAGCTGACTCTGTCCAGCGGCCCAGTGATGCTCACACCAAGCCTCGCCCTGCACTAGCTGCCGCCACAACTATTATCACCTGCCCTC
CGTCAGCATCAGCTTCCACCCTGGACCAGTCCAAGGACCCTGGGCCTCCCCGGCCACACAGGCCTGAAGCTACCCCCAGCATGGCCTCTC
TGGGCCCAGAGGGGAAACTGAGGCCTGAGCCGAGAAGGGATGGGGAGGCTCAGGAGGCTGCGAGTGAGACTCAGCCCCTGAGCTCTCCCC
CAACAGCTGCCAGCTCCAAGGCCCCCAGCAGTGGGAGTGCCCAGCCACCAGAGGGTCACCCAGGCAAGCCTGAGCCCAGCCGGGCTAAGT
CCCGCCCCCTGCCCAACATGCCAAAGCTGGTCATCCCCTCCGCCGCCACCAAGTTCCCCCCTGAGATCACCGTCACGCCACCCACCCCAA
CCCTGCTCTCCCCCAAAGGCAGCATCTCGGAGGAGACCAAGCAGAAGCTGAAGTCAGCCATCCTTTCTGCCCAGTCTGCTGCCAACGTGA
GGAAGGAGAGCCTATGCCAGCCAGCCCTGGAGGTCCTGGAGACATCCAGCCAGGAGTCCTCGCTGGAGAGCGAGACAGACGAGGACGACG
ACTACATGGACATTTGAGGGGCCACTGCAGCCCCACCGCCACGCCCCAGGGGACCAGCCAGGCCTGGAATGCCCCCTGGGCAGGACCCTG
GGCAGGACCAGAGGCCCACATGGATGCCACTCCCCACACAGCCCCCAGGCCTGCCCAGCCCACCTCCTCATGGCATCCTCCCTGTACCCA
GGTCAGGCTGTCCACACCACATGGGAGCCCAGAGGAGGAGGGGCCCGCCTTAGCCATGTGAAGGTGGATTGGTCGCCATCTGCACGCCAG
GCGGCATCCTTTTCTATGAAGTGTTGACTTTGTAAATCTGCCCACACCCAGCTGGCCATATCCACCCCTCGACGCCGGGATGAGCCGGCT

>36430_36430_2_HIRA-CABIN1_HIRA_chr22_19371143_ENST00000541063_CABIN1_chr22_24560368_ENST00000337989_length(amino acids)=591AA_BP=8
MHSTAGHWGIWRIPVDEIDRPGSFAWHMNRSIVLLLKVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTL
SELAEGSERPGPKVCGLPGARMTTDVSHKASPEDGQEGLPQPKKPPLADGSGPGPEPGGKVGLLNHRPVAMDAGDSADQSGERKDKESPR
AGPTEPMDTSEATVCHSDLERTPPLLPGRPARDRGPESRPTELSLEELSISARQQPTPLTPAQPAPAPAPATTTGTRAGGHPEEPLSRLS
RKRKLLEDTESGKTLLLDAYRVWQQGQKGVAYDLGRVERIMSETYMLIKQVDEEAALEQAVKFCQVHLGAAAQRQASGDTPTTPKHPKDS
RENFFPVTVVPTAPDPVPADSVQRPSDAHTKPRPALAAATTIITCPPSASASTLDQSKDPGPPRPHRPEATPSMASLGPEGKLRPEPRRD
GEAQEAASETQPLSSPPTAASSKAPSSGSAQPPEGHPGKPEPSRAKSRPLPNMPKLVIPSAATKFPPEITVTPPTPTLLSPKGSISEETK

--------------------------------------------------------------
>36430_36430_3_HIRA-CABIN1_HIRA_chr22_19371143_ENST00000541063_CABIN1_chr22_24560368_ENST00000398319_length(transcript)=3764nt_BP=1415nt
CGGTCGCCCAGACATGGCGGACGGCAGCGGCTGGCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACT
GGAGGACAAGGGCAGGATTCTGGGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCC
AAGATGCTTTGCCAGATGGACAATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGAT
GACAAACTGATTATGGTGTGGAAGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAG
TGGCGGTGTGTCTCTATCCTCCGGAATCATTCAGGCGATGTGATGGATGTAGCATGGTCTCCCCACGATGCCTGGCTAGCCTCATGCAGC
GTGGATAACACTGTCGTCATCTGGAATGCTGTAAAGTTCCCAGAAATTCTAGCTACTCTGAGAGGTCATTCTGGCTTGGTCAAAGGGTTG
ACATGGGACCCTGTTGGTAAATACATAGCTTCTCAAGCTGATGACCGCAGCCTAAAGGTGTGGAGGACGCTGGACTGGCAGTTGGAGACC
AGCATCACCAAGCCTTTTGATGAGTGTGGAGGAACGACCCATGTGTTGCGGCTCAGCTGGTCACCTGATGGGCATTACCTGGTGTCTGCC
CATGCCATGAACAACTCAGGCCCCACTGCCCAGATCATCGAACGGGAGGGATGGAAGACCAACATGGACTTTGTTGGGCACCGGAAAGCT
GTGACTGTCGTGAAATTCAACCCAAAAATCTTCAAAAAGAAGCAGAAGAATGGGAGTTCTGCGAAGCCTAGCTGCCCGTACTGCTGCTGT
GCTGTTGGCAGCAAGGACCGCTCGCTTTCTGTCTGGCTCACATGTCTGAAACGGCCGCTGGTGGTCATCCATGAACTGTTTGACAAATCC
ATCATGGATATTTCCTGGACTCTGAATGGGCTGGGCATCTTGGTATGCTCTATGGACGGCTCTGTGGCATTCCTCGACTTCTCCCAGGAT
GAGCTTGGCGATCCCCTGAGCGAGGAGGAGAAGAGCCGCATTCACCAGTCCACCTATGGCAAGAGCCTAGCCATCATGACCGAGGCCCAG
CTCTCCACAGCCGTCATTGAGAACCCTGAGATGCTCAAGTACCAGCGAAGGCAGCAGCAGCAGCAGCTGGACCAGAAGAGTGCTGCGACC
AGGGAGATGGGCTCAGCCACCTCAGTCGCAGGCGTTGTCAACGGGGAGAGTCTTGAAGATATCAGGAAGAATCTTTTGAAGAAACAAGTT
GAGACTCGGACAGCAGATGGCCGGAGAAGAATCACGCCTCTCTGCATAGCACAGCTGGACACTGGGGCATCTGGCGGATCCCCGTGGACG
AGATTGACCGGCCGGGCAGCTTTGCCTGGCACATGAACCGCTCCATCGTGCTGCTGCTCAAGGTGCTGGCCCAGCTGCGGGACCACAGCA
CCCTGCTGAAGGTGTCCTCCATGCTTCAGCGGACCCCAGACCAGGGCAAGAAGTATCTGCGAGATGCTGACCGCCAGGTCCTGGCGCAGC
GGGCCTTCATCCTCACTGTGAAGGTGCTCGAAGACACGCTGAGCGAGCTCGCAGAGGGGTCAGAACGCCCAGGGCCCAAGGTCTGTGGCC
TCCCCGGAGCCAGGATGACCACCGATGTCTCACACAAGGCCAGTCCTGAGGATGGCCAGGAGGGCCTCCCCCAGCCGAAGAAGCCCCCTC
TGGCTGATGGCTCAGGGCCAGGGCCCGAGCCAGGAGGCAAAGTGGGCCTCCTCAACCACCGGCCTGTGGCCATGGATGCAGGAGACAGTG
CAGACCAAAGCGGGGAGCGGAAGGATAAAGAGAGCCCACGGGCAGGGCCCACTGAGCCCATGGACACGAGTGAGGCCACTGTTTGCCACT
CAGACTTGGAGCGGACACCACCCCTGCTGCCAGGTCGCCCCGCAAGGGACCGGGGCCCCGAGAGCCGGCCCACTGAGCTGTCCCTGGAGG
AGCTGAGCATCAGTGCCCGGCAGCAGCCCACCCCGCTCACCCCAGCCCAGCCAGCCCCCGCCCCCGCCCCCGCCACCACCACAGGGACCA
GGGCAGGGGGCCACCCGGAGGAGCCGCTCTCCCGGCTCAGCCGCAAGAGGAAGCTCCTGGAGGACACAGAGTCAGGCAAGACACTTCTGT
TGGATGCCTACCGTGTGTGGCAGCAGGGCCAGAAGGGTGTGGCCTATGACCTGGGCCGTGTGGAGAGGATCATGTCGGAGACCTACATGC
TCATCAAGCAGGTGGATGAGGAGGCTGCGCTGGAGCAGGCTGTGAAGTTCTGCCAGGTCCATCTTGGGGCTGCCGCCCAGAGACAGGCCT
CGGGGGACACCCCCACCACTCCAAAGCACCCCAAAGACAGCCGAGAGAACTTCTTTCCTGTGACAGTGGTGCCCACAGCCCCTGACCCTG
TGCCAGCTGACTCTGTCCAGCGGCCCAGTGATGCTCACACCAAGCCTCGCCCTGCACTAGCTGCCGCCACAACTATTATCACCTGCCCTC
CGTCAGCATCAGCTTCCACCCTGGACCAGTCCAAGGACCCTGGGCCTCCCCGGCCACACAGGCCTGAAGCTACCCCCAGCATGGCCTCTC
TGGGCCCAGAGGGAGAAGAGCTGGCGAGAGTGGCAGAGGGCACCAGCTTCCCGCCTCAGGAGCCACGGCACAGTCCGCAGGTGAAGATGG
CCCCCACAAGTTCCCCGGCAGAGCCACACTGCTGGCCGGCAGAGGCTGCCCTGGGCACAGGCGCTGAGCCCACCTGCAGCCAGGAGGGGA
AACTGAGGCCTGAGCCGAGAAGGGATGGGGAGGCTCAGGAGGCTGCGAGTGAGACTCAGCCCCTGAGCTCTCCCCCAACAGCTGCCAGCT
CCAAGGCCCCCAGCAGTGGGAGTGCCCAGCCACCAGAGGGTCACCCAGGCAAGCCTGAGCCCAGCCGGGCTAAGTCCCGCCCCCTGCCCA
ACATGCCAAAGCTGGTCATCCCCTCCGCCGCCACCAAGTTCCCCCCTGAGATCACCGTCACGCCACCCACCCCAACCCTGCTCTCCCCCA
AAGGCAGCATCTCGGAGGAGACCAAGCAGAAGCTGAAGTCAGCCATCCTTTCTGCCCAGTCTGCTGCCAACGTGAGGAAGGAGAGCCTAT
GCCAGCCAGCCCTGGAGGTCCTGGAGACATCCAGCCAGGAGTCCTCGCTGGAGAGCGAGACAGACGAGGACGACGACTACATGGACATTT
GAGGGGCCACTGCAGCCCCACCGCCACGCCCCAGGGGACCAGCCAGGCCTGGAATGCCCCCTGGGCAGGACCCTGGGCAGGACCAGAGGC
CCACATGGATGCCACTCCCCACACAGCCCCCAGGCCTGCCCAGCCCACCTCCTCATGGCATCCTCCCTGTACCCAGGTCAGGCTGTCCAC
ACCACATGGGAGCCCAGAGGAGGAGGGGCCCGCCTTAGCCATGTGAAGGTGGATTGGTCGCCATCTGCACGCCAGGCGGCATCCTTTTCT
ATGAAGTGTTGACTTTGTAAATCTGCCCACACCCAGCTGGCCATATCCACCCCTCGACGCCGGGATGAGCCGGCTCTGCCTGTGTCACAG

>36430_36430_3_HIRA-CABIN1_HIRA_chr22_19371143_ENST00000541063_CABIN1_chr22_24560368_ENST00000398319_length(amino acids)=646AA_BP=8
MHSTAGHWGIWRIPVDEIDRPGSFAWHMNRSIVLLLKVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTL
SELAEGSERPGPKVCGLPGARMTTDVSHKASPEDGQEGLPQPKKPPLADGSGPGPEPGGKVGLLNHRPVAMDAGDSADQSGERKDKESPR
AGPTEPMDTSEATVCHSDLERTPPLLPGRPARDRGPESRPTELSLEELSISARQQPTPLTPAQPAPAPAPATTTGTRAGGHPEEPLSRLS
RKRKLLEDTESGKTLLLDAYRVWQQGQKGVAYDLGRVERIMSETYMLIKQVDEEAALEQAVKFCQVHLGAAAQRQASGDTPTTPKHPKDS
RENFFPVTVVPTAPDPVPADSVQRPSDAHTKPRPALAAATTIITCPPSASASTLDQSKDPGPPRPHRPEATPSMASLGPEGEELARVAEG
TSFPPQEPRHSPQVKMAPTSSPAEPHCWPAEAALGTGAEPTCSQEGKLRPEPRRDGEAQEAASETQPLSSPPTAASSKAPSSGSAQPPEG
HPGKPEPSRAKSRPLPNMPKLVIPSAATKFPPEITVTPPTPTLLSPKGSISEETKQKLKSAILSAQSAANVRKESLCQPALEVLETSSQE

--------------------------------------------------------------
>36430_36430_4_HIRA-CABIN1_HIRA_chr22_19371143_ENST00000541063_CABIN1_chr22_24560368_ENST00000405822_length(transcript)=3764nt_BP=1415nt
CGGTCGCCCAGACATGGCGGACGGCAGCGGCTGGCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACT
GGAGGACAAGGGCAGGATTCTGGGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCC
AAGATGCTTTGCCAGATGGACAATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGAT
GACAAACTGATTATGGTGTGGAAGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAG
TGGCGGTGTGTCTCTATCCTCCGGAATCATTCAGGCGATGTGATGGATGTAGCATGGTCTCCCCACGATGCCTGGCTAGCCTCATGCAGC
GTGGATAACACTGTCGTCATCTGGAATGCTGTAAAGTTCCCAGAAATTCTAGCTACTCTGAGAGGTCATTCTGGCTTGGTCAAAGGGTTG
ACATGGGACCCTGTTGGTAAATACATAGCTTCTCAAGCTGATGACCGCAGCCTAAAGGTGTGGAGGACGCTGGACTGGCAGTTGGAGACC
AGCATCACCAAGCCTTTTGATGAGTGTGGAGGAACGACCCATGTGTTGCGGCTCAGCTGGTCACCTGATGGGCATTACCTGGTGTCTGCC
CATGCCATGAACAACTCAGGCCCCACTGCCCAGATCATCGAACGGGAGGGATGGAAGACCAACATGGACTTTGTTGGGCACCGGAAAGCT
GTGACTGTCGTGAAATTCAACCCAAAAATCTTCAAAAAGAAGCAGAAGAATGGGAGTTCTGCGAAGCCTAGCTGCCCGTACTGCTGCTGT
GCTGTTGGCAGCAAGGACCGCTCGCTTTCTGTCTGGCTCACATGTCTGAAACGGCCGCTGGTGGTCATCCATGAACTGTTTGACAAATCC
ATCATGGATATTTCCTGGACTCTGAATGGGCTGGGCATCTTGGTATGCTCTATGGACGGCTCTGTGGCATTCCTCGACTTCTCCCAGGAT
GAGCTTGGCGATCCCCTGAGCGAGGAGGAGAAGAGCCGCATTCACCAGTCCACCTATGGCAAGAGCCTAGCCATCATGACCGAGGCCCAG
CTCTCCACAGCCGTCATTGAGAACCCTGAGATGCTCAAGTACCAGCGAAGGCAGCAGCAGCAGCAGCTGGACCAGAAGAGTGCTGCGACC
AGGGAGATGGGCTCAGCCACCTCAGTCGCAGGCGTTGTCAACGGGGAGAGTCTTGAAGATATCAGGAAGAATCTTTTGAAGAAACAAGTT
GAGACTCGGACAGCAGATGGCCGGAGAAGAATCACGCCTCTCTGCATAGCACAGCTGGACACTGGGGCATCTGGCGGATCCCCGTGGACG
AGATTGACCGGCCGGGCAGCTTTGCCTGGCACATGAACCGCTCCATCGTGCTGCTGCTCAAGGTGCTGGCCCAGCTGCGGGACCACAGCA
CCCTGCTGAAGGTGTCCTCCATGCTTCAGCGGACCCCAGACCAGGGCAAGAAGTATCTGCGAGATGCTGACCGCCAGGTCCTGGCGCAGC
GGGCCTTCATCCTCACTGTGAAGGTGCTCGAAGACACGCTGAGCGAGCTCGCAGAGGGGTCAGAACGCCCAGGGCCCAAGGTCTGTGGCC
TCCCCGGAGCCAGGATGACCACCGATGTCTCACACAAGGCCAGTCCTGAGGATGGCCAGGAGGGCCTCCCCCAGCCGAAGAAGCCCCCTC
TGGCTGATGGCTCAGGGCCAGGGCCCGAGCCAGGAGGCAAAGTGGGCCTCCTCAACCACCGGCCTGTGGCCATGGATGCAGGAGACAGTG
CAGACCAAAGCGGGGAGCGGAAGGATAAAGAGAGCCCACGGGCAGGGCCCACTGAGCCCATGGACACGAGTGAGGCCACTGTTTGCCACT
CAGACTTGGAGCGGACACCACCCCTGCTGCCAGGTCGCCCCGCAAGGGACCGGGGCCCCGAGAGCCGGCCCACTGAGCTGTCCCTGGAGG
AGCTGAGCATCAGTGCCCGGCAGCAGCCCACCCCGCTCACCCCAGCCCAGCCAGCCCCCGCCCCCGCCCCCGCCACCACCACAGGGACCA
GGGCAGGGGGCCACCCGGAGGAGCCGCTCTCCCGGCTCAGCCGCAAGAGGAAGCTCCTGGAGGACACAGAGTCAGGCAAGACACTTCTGT
TGGATGCCTACCGTGTGTGGCAGCAGGGCCAGAAGGGTGTGGCCTATGACCTGGGCCGTGTGGAGAGGATCATGTCGGAGACCTACATGC
TCATCAAGCAGGTGGATGAGGAGGCTGCGCTGGAGCAGGCTGTGAAGTTCTGCCAGGTCCATCTTGGGGCTGCCGCCCAGAGACAGGCCT
CGGGGGACACCCCCACCACTCCAAAGCACCCCAAAGACAGCCGAGAGAACTTCTTTCCTGTGACAGTGGTGCCCACAGCCCCTGACCCTG
TGCCAGCTGACTCTGTCCAGCGGCCCAGTGATGCTCACACCAAGCCTCGCCCTGCACTAGCTGCCGCCACAACTATTATCACCTGCCCTC
CGTCAGCATCAGCTTCCACCCTGGACCAGTCCAAGGACCCTGGGCCTCCCCGGCCACACAGGCCTGAAGCTACCCCCAGCATGGCCTCTC
TGGGCCCAGAGGGAGAAGAGCTGGCGAGAGTGGCAGAGGGCACCAGCTTCCCGCCTCAGGAGCCACGGCACAGTCCGCAGGTGAAGATGG
CCCCCACAAGTTCCCCGGCAGAGCCACACTGCTGGCCGGCAGAGGCTGCCCTGGGCACAGGCGCTGAGCCCACCTGCAGCCAGGAGGGGA
AACTGAGGCCTGAGCCGAGAAGGGATGGGGAGGCTCAGGAGGCTGCGAGTGAGACTCAGCCCCTGAGCTCTCCCCCAACAGCTGCCAGCT
CCAAGGCCCCCAGCAGTGGGAGTGCCCAGCCACCAGAGGGTCACCCAGGCAAGCCTGAGCCCAGCCGGGCTAAGTCCCGCCCCCTGCCCA
ACATGCCAAAGCTGGTCATCCCCTCCGCCGCCACCAAGTTCCCCCCTGAGATCACCGTCACGCCACCCACCCCAACCCTGCTCTCCCCCA
AAGGCAGCATCTCGGAGGAGACCAAGCAGAAGCTGAAGTCAGCCATCCTTTCTGCCCAGTCTGCTGCCAACGTGAGGAAGGAGAGCCTAT
GCCAGCCAGCCCTGGAGGTCCTGGAGACATCCAGCCAGGAGTCCTCGCTGGAGAGCGAGACAGACGAGGACGACGACTACATGGACATTT
GAGGGGCCACTGCAGCCCCACCGCCACGCCCCAGGGGACCAGCCAGGCCTGGAATGCCCCCTGGGCAGGACCCTGGGCAGGACCAGAGGC
CCACATGGATGCCACTCCCCACACAGCCCCCAGGCCTGCCCAGCCCACCTCCTCATGGCATCCTCCCTGTACCCAGGTCAGGCTGTCCAC
ACCACATGGGAGCCCAGAGGAGGAGGGGCCCGCCTTAGCCATGTGAAGGTGGATTGGTCGCCATCTGCACGCCAGGCGGCATCCTTTTCT
ATGAAGTGTTGACTTTGTAAATCTGCCCACACCCAGCTGGCCATATCCACCCCTCGACGCCGGGATGAGCCGGCTCTGCCTGTGTCACAG

>36430_36430_4_HIRA-CABIN1_HIRA_chr22_19371143_ENST00000541063_CABIN1_chr22_24560368_ENST00000405822_length(amino acids)=646AA_BP=8
MHSTAGHWGIWRIPVDEIDRPGSFAWHMNRSIVLLLKVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTL
SELAEGSERPGPKVCGLPGARMTTDVSHKASPEDGQEGLPQPKKPPLADGSGPGPEPGGKVGLLNHRPVAMDAGDSADQSGERKDKESPR
AGPTEPMDTSEATVCHSDLERTPPLLPGRPARDRGPESRPTELSLEELSISARQQPTPLTPAQPAPAPAPATTTGTRAGGHPEEPLSRLS
RKRKLLEDTESGKTLLLDAYRVWQQGQKGVAYDLGRVERIMSETYMLIKQVDEEAALEQAVKFCQVHLGAAAQRQASGDTPTTPKHPKDS
RENFFPVTVVPTAPDPVPADSVQRPSDAHTKPRPALAAATTIITCPPSASASTLDQSKDPGPPRPHRPEATPSMASLGPEGEELARVAEG
TSFPPQEPRHSPQVKMAPTSSPAEPHCWPAEAALGTGAEPTCSQEGKLRPEPRRDGEAQEAASETQPLSSPPTAASSKAPSSGSAQPPEG
HPGKPEPSRAKSRPLPNMPKLVIPSAATKFPPEITVTPPTPTLLSPKGSISEETKQKLKSAILSAQSAANVRKESLCQPALEVLETSSQE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HIRA-CABIN1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	HIRA	chr22:19371143	chr22:24560368	ENST00000263208	-	13	25	421_479	471.6666666666667	1018.0	ASF1A
Hgene	HIRA	chr22:19371143	chr22:24560368	ENST00000340170	-	13	21	421_479	471.6666666666667	811.0	ASF1A
Hgene	HIRA	chr22:19371143	chr22:24560368	ENST00000263208	-	13	25	421_729	471.6666666666667	1018.0	CCNA1
Hgene	HIRA	chr22:19371143	chr22:24560368	ENST00000340170	-	13	21	421_729	471.6666666666667	811.0	CCNA1
Hgene	HIRA	chr22:19371143	chr22:24560368	ENST00000263208	-	13	25	593_826	471.6666666666667	1018.0	histone H2B
Hgene	HIRA	chr22:19371143	chr22:24560368	ENST00000340170	-	13	21	593_826	471.6666666666667	811.0	histone H2B
Hgene	HIRA	chr22:19371143	chr22:24560368	ENST00000263208	-	13	25	738_1017	471.6666666666667	1018.0	histone H4
Hgene	HIRA	chr22:19371143	chr22:24560368	ENST00000340170	-	13	21	738_1017	471.6666666666667	811.0	histone H4
Hgene	HIRA	chr22:19371143	chr22:24560368	ENST00000263208	-	13	25	594_739	471.6666666666667	1018.0	PAX3
Hgene	HIRA	chr22:19371143	chr22:24560368	ENST00000263208	-	13	25	740_828	471.6666666666667	1018.0	PAX3
Hgene	HIRA	chr22:19371143	chr22:24560368	ENST00000340170	-	13	21	594_739	471.6666666666667	811.0	PAX3
Hgene	HIRA	chr22:19371143	chr22:24560368	ENST00000340170	-	13	21	740_828	471.6666666666667	811.0	PAX3

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for HIRA-CABIN1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for HIRA-CABIN1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source