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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HIVEP3-CREB3L4 (FusionGDB2 ID:36553)

Fusion Gene Summary for HIVEP3-CREB3L4

Fusion gene summary

Fusion gene information	Fusion gene name: HIVEP3-CREB3L4
	Fusion gene ID: 36553
		Hgene	Tgene
	Gene symbol	HIVEP3	CREB3L4
	Gene ID	59269	148327
	Gene name	HIVEP zinc finger 3	cAMP responsive element binding protein 3 like 4
	Synonyms	KBP-1\|KBP1\|KRC\|SHN3\|Schnurri-3\|ZAS3\|ZNF40C	AIBZIP\|ATCE1\|CREB3\|CREB4\|JAL\|hJAL
	Cytomap	1p34.2	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	transcription factor HIVEP3ZAS family, member 3human immunodeficiency virus type I enhancer binding protein 3kappa-B and V(D)J recombination signal sequences-binding proteinkappa-binding protein 1zinc finger protein ZAS3	cyclic AMP-responsive element-binding protein 3-like protein 4CREB-4androgen-induced basic leucine zipper proteinattaching to CRE-like 1cAMP responsive element binding protein 1cAMP-responsive element-binding protein 3-like protein 4cAMP-responsive
	Modification date	20200313	20200313
	UniProtAcc	Q5T1R4	Q8TEY5
	Ensembl transtripts involved in fusion gene	ENST00000247584, ENST00000372583, ENST00000429157, ENST00000372584, ENST00000460604,	ENST00000271889, ENST00000368607, ENST00000405694, ENST00000468845, ENST00000368600, ENST00000368601, ENST00000368603,
Fusion gene scores	* DoF score	21 X 18 X 10=3780	5 X 7 X 2=70
	# samples	25	5
	** MAII score	log2(25/3780*10)=-3.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/70*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HIVEP3 [Title/Abstract] AND CREB3L4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HIVEP3(42166587)-CREB3L4(153945671), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HIVEP3	GO:0045893	positive regulation of transcription, DNA-templated	15790681
Tgene	CREB3L4	GO:0045944	positive regulation of transcription by RNA polymerase II	16236796

Fusion gene breakpoints across HIVEP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CREB3L4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A18J-01A	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
ChimerDB4	BRCA	TCGA-BH-A18J-01A	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+

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Fusion Gene ORF analysis for HIVEP3-CREB3L4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000247584	ENST00000271889	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-3CDS	ENST00000247584	ENST00000271889	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-3CDS	ENST00000247584	ENST00000368607	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-3CDS	ENST00000247584	ENST00000368607	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-3CDS	ENST00000247584	ENST00000405694	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-3CDS	ENST00000247584	ENST00000405694	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-3CDS	ENST00000372583	ENST00000271889	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-3CDS	ENST00000372583	ENST00000271889	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-3CDS	ENST00000372583	ENST00000368607	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-3CDS	ENST00000372583	ENST00000368607	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-3CDS	ENST00000372583	ENST00000405694	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-3CDS	ENST00000372583	ENST00000405694	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-3CDS	ENST00000429157	ENST00000271889	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-3CDS	ENST00000429157	ENST00000271889	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-3CDS	ENST00000429157	ENST00000368607	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-3CDS	ENST00000429157	ENST00000368607	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-3CDS	ENST00000429157	ENST00000405694	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-3CDS	ENST00000429157	ENST00000405694	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-3UTR	ENST00000247584	ENST00000468845	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-3UTR	ENST00000247584	ENST00000468845	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-3UTR	ENST00000372583	ENST00000468845	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-3UTR	ENST00000372583	ENST00000468845	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-3UTR	ENST00000429157	ENST00000468845	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-3UTR	ENST00000429157	ENST00000468845	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-intron	ENST00000247584	ENST00000368600	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-intron	ENST00000247584	ENST00000368600	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-intron	ENST00000247584	ENST00000368601	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-intron	ENST00000247584	ENST00000368601	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-intron	ENST00000247584	ENST00000368603	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-intron	ENST00000247584	ENST00000368603	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-intron	ENST00000372583	ENST00000368600	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-intron	ENST00000372583	ENST00000368600	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-intron	ENST00000372583	ENST00000368601	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-intron	ENST00000372583	ENST00000368601	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-intron	ENST00000372583	ENST00000368603	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-intron	ENST00000372583	ENST00000368603	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-intron	ENST00000429157	ENST00000368600	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-intron	ENST00000429157	ENST00000368600	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-intron	ENST00000429157	ENST00000368601	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-intron	ENST00000429157	ENST00000368601	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
5UTR-intron	ENST00000429157	ENST00000368603	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
5UTR-intron	ENST00000429157	ENST00000368603	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-3CDS	ENST00000372584	ENST00000271889	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-3CDS	ENST00000372584	ENST00000271889	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-3CDS	ENST00000372584	ENST00000368607	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-3CDS	ENST00000372584	ENST00000368607	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-3CDS	ENST00000372584	ENST00000405694	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-3CDS	ENST00000372584	ENST00000405694	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-3CDS	ENST00000460604	ENST00000271889	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-3CDS	ENST00000460604	ENST00000271889	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-3CDS	ENST00000460604	ENST00000368607	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-3CDS	ENST00000460604	ENST00000368607	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-3CDS	ENST00000460604	ENST00000405694	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-3CDS	ENST00000460604	ENST00000405694	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-3UTR	ENST00000372584	ENST00000468845	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-3UTR	ENST00000372584	ENST00000468845	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-3UTR	ENST00000460604	ENST00000468845	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-3UTR	ENST00000460604	ENST00000468845	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-intron	ENST00000372584	ENST00000368600	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-intron	ENST00000372584	ENST00000368600	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-intron	ENST00000372584	ENST00000368601	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-intron	ENST00000372584	ENST00000368601	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-intron	ENST00000372584	ENST00000368603	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-intron	ENST00000372584	ENST00000368603	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-intron	ENST00000460604	ENST00000368600	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-intron	ENST00000460604	ENST00000368600	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-intron	ENST00000460604	ENST00000368601	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-intron	ENST00000460604	ENST00000368601	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+
intron-intron	ENST00000460604	ENST00000368603	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153945671	+
intron-intron	ENST00000460604	ENST00000368603	HIVEP3	chr1	42166587	-	CREB3L4	chr1	153946096	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for HIVEP3-CREB3L4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HIVEP3	chr1	42166586	-	CREB3L4	chr1	153945670	+	0.104876034	0.895124
HIVEP3	chr1	42166586	-	CREB3L4	chr1	153946095	+	0.000250097	0.99974996
HIVEP3	chr1	42166586	-	CREB3L4	chr1	153945670	+	0.104876034	0.895124
HIVEP3	chr1	42166586	-	CREB3L4	chr1	153946095	+	0.000250097	0.99974996

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HIVEP3-CREB3L4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:42166587/:153945671)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HIVEP3 Q5T1R4	CREB3L4 Q8TEY5
FUNCTION: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269\|PubMed:11161801}.	FUNCTION: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). {ECO:0000250, ECO:0000269\|PubMed:16236796}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HIVEP3-CREB3L4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HIVEP3-CREB3L4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HIVEP3-CREB3L4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HIVEP3-CREB3L4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source