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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HLA-E-ETF1 (FusionGDB2 ID:36702)

Fusion Gene Summary for HLA-E-ETF1

check button Fusion gene summary
Fusion gene informationFusion gene name: HLA-E-ETF1
Fusion gene ID: 36702
HgeneTgene
Gene symbol

HLA-E

ETF1

Gene ID

3133

2107

Gene namemajor histocompatibility complex, class I, Eeukaryotic translation termination factor 1
SynonymsHLA-6.2|QA1D5S1995|ERF|ERF1|RF1|SUP45L1|TB3-1
Cytomap

6p22.1

5q31.2

Type of geneprotein-codingprotein-coding
DescriptionHLA class I histocompatibility antigen, alpha chain EMHC class I antigen EMHC class Ib antigeneukaryotic peptide chain release factor subunit 1polypeptide chain release factor 1protein Cl1sup45 (yeast omnipotent suppressor 45) homolog-like 1
Modification date2020031320200329
UniProtAcc

P13747

P62495

Ensembl transtripts involved in fusion geneENST00000376630, ENST00000383597, 
ENST00000415289, ENST00000415649, 
ENST00000425603, ENST00000427936, 
ENST00000444683, 		ENST00000514005, 
ENST00000360541, ENST00000499810, 
ENST00000503014, 
Fusion gene scores* DoF score8 X 7 X 1=569 X 7 X 4=252
# samples 810
** MAII scorelog2(8/56*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HLA-E [Title/Abstract] AND ETF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHLA-E(30457673)-ETF1(137848637), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHLA-E

GO:0001815

positive regulation of antibody-dependent cellular cytotoxicity

30134159

HgeneHLA-E

GO:0001916

positive regulation of T cell mediated cytotoxicity

25631937

HgeneHLA-E

GO:0002250

adaptive immune response

25631937

HgeneHLA-E

GO:0002476

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

9754572

HgeneHLA-E

GO:0002477

antigen processing and presentation of exogenous peptide antigen via MHC class Ib

30087334

HgeneHLA-E

GO:0002519

natural killer cell tolerance induction

9486650

HgeneHLA-E

GO:0002715

regulation of natural killer cell mediated immunity

18448674

HgeneHLA-E

GO:0002717

positive regulation of natural killer cell mediated immunity

9754572

HgeneHLA-E

GO:0002729

positive regulation of natural killer cell cytokine production

30134159

HgeneHLA-E

GO:0019731

antibacterial humoral response

25631937

HgeneHLA-E

GO:0032736

positive regulation of interleukin-13 production

25631937

HgeneHLA-E

GO:0032753

positive regulation of interleukin-4 production

25631937

HgeneHLA-E

GO:0032759

positive regulation of TRAIL production

25631937

HgeneHLA-E

GO:0032760

positive regulation of tumor necrosis factor production

25631937

HgeneHLA-E

GO:0032819

positive regulation of natural killer cell proliferation

30134159

HgeneHLA-E

GO:0036037

CD8-positive, alpha-beta T cell activation

25631937

HgeneHLA-E

GO:0042270

protection from natural killer cell mediated cytotoxicity

9754572|25631937

HgeneHLA-E

GO:0045953

negative regulation of natural killer cell mediated cytotoxicity

9486650|10799855|17179229|23335510

HgeneHLA-E

GO:0045954

positive regulation of natural killer cell mediated cytotoxicity

23335510

HgeneHLA-E

GO:0050830

defense response to Gram-positive bacterium

25631937

HgeneHLA-E

GO:0051024

positive regulation of immunoglobulin secretion

25631937

HgeneHLA-E

GO:2000566

positive regulation of CD8-positive, alpha-beta T cell proliferation

25631937

HgeneHLA-E

GO:2001187

positive regulation of CD8-positive, alpha-beta T cell activation

28676677

TgeneETF1

GO:0006415

translational termination

7990965

TgeneETF1

GO:0006479

protein methylation

18539146


check buttonFusion gene breakpoints across HLA-E (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ETF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG534374HLA-Echr6

30457673

+ETF1chr5

137848637

-


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Fusion Gene ORF analysis for HLA-E-ETF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000376630ENST00000514005HLA-Echr6

30457673

+ETF1chr5

137848637

-
In-frameENST00000376630ENST00000360541HLA-Echr6

30457673

+ETF1chr5

137848637

-
In-frameENST00000376630ENST00000499810HLA-Echr6

30457673

+ETF1chr5

137848637

-
In-frameENST00000376630ENST00000503014HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000383597ENST00000360541HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000383597ENST00000499810HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000383597ENST00000503014HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000415289ENST00000360541HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000415289ENST00000499810HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000415289ENST00000503014HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000415649ENST00000360541HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000415649ENST00000499810HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000415649ENST00000503014HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000425603ENST00000360541HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000425603ENST00000499810HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000425603ENST00000503014HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000427936ENST00000360541HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000427936ENST00000499810HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000427936ENST00000503014HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000444683ENST00000360541HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000444683ENST00000499810HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-3CDSENST00000444683ENST00000503014HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-intronENST00000383597ENST00000514005HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-intronENST00000415289ENST00000514005HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-intronENST00000415649ENST00000514005HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-intronENST00000425603ENST00000514005HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-intronENST00000427936ENST00000514005HLA-Echr6

30457673

+ETF1chr5

137848637

-
intron-intronENST00000444683ENST00000514005HLA-Echr6

30457673

+ETF1chr5

137848637

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376630HLA-Echr630457673+ENST00000499810ETF1chr5137848637-3211228651000311
ENST00000376630HLA-Echr630457673+ENST00000360541ETF1chr5137848637-3207228651000311
ENST00000376630HLA-Echr630457673+ENST00000503014ETF1chr5137848637-1316228651000311

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376630ENST00000499810HLA-Echr630457673+ETF1chr5137848637-7.06E-050.9999294
ENST00000376630ENST00000360541HLA-Echr630457673+ETF1chr5137848637-6.99E-050.99993
ENST00000376630ENST00000503014HLA-Echr630457673+ETF1chr5137848637-0.0001567870.99984324

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Fusion Genomic Features for HLA-E-ETF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HLA-E-ETF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:30457673/chr5:137848637)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HLA-E

P13747

ETF1

P62495

FUNCTION: Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8+ cytotoxic T cells, ultimately triggering antimicrobial immune response (PubMed:16474394, PubMed:30087334). {ECO:0000269|PubMed:12461076, ECO:0000269|PubMed:16474394, ECO:0000269|PubMed:17179229, ECO:0000269|PubMed:18083576, ECO:0000269|PubMed:18339401, ECO:0000269|PubMed:30087334, ECO:0000269|PubMed:30134159, ECO:0000269|PubMed:9486650, ECO:0000269|PubMed:9754572}.; FUNCTION: (Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells. {ECO:0000269|PubMed:10799855, ECO:0000269|PubMed:23335510}.; FUNCTION: (Microbial infection) May bind HIV-1 gag/Capsid protein p24-derived peptide (AISPRTLNA) on infected cells and may inhibit NK cell cytotoxicity, a mechanism that allows HIV-1 to escape immune recognition. {ECO:0000269|PubMed:15751767}.; FUNCTION: (Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells (PubMed:32859121). Binds SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening antiviral immune surveillance (PubMed:32859121). {ECO:0000269|PubMed:32859121}.FUNCTION: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (PubMed:7990965, PubMed:24486019). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:30682371, ECO:0000269|PubMed:7990965}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHLA-Echr6:30457673chr5:137848637ENST00000383597+18206_2940801.6666666666666DomainNote=Ig-like C1-type
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415289+18206_2940801.6666666666666DomainNote=Ig-like C1-type
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415649+18206_2940801.6666666666666DomainNote=Ig-like C1-type
HgeneHLA-Echr6:30457673chr5:137848637ENST00000427936+18206_2940801.6666666666666DomainNote=Ig-like C1-type
HgeneHLA-Echr6:30457673chr5:137848637ENST00000383597+18112_2030801.6666666666666RegionNote=Alpha-2
HgeneHLA-Echr6:30457673chr5:137848637ENST00000383597+18204_2950801.6666666666666RegionNote=Alpha-3
HgeneHLA-Echr6:30457673chr5:137848637ENST00000383597+1822_1110801.6666666666666RegionNote=Alpha-1
HgeneHLA-Echr6:30457673chr5:137848637ENST00000383597+18296_3050801.6666666666666RegionNote=Connecting peptide
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415289+18112_2030801.6666666666666RegionNote=Alpha-2
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415289+18204_2950801.6666666666666RegionNote=Alpha-3
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415289+1822_1110801.6666666666666RegionNote=Alpha-1
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415289+18296_3050801.6666666666666RegionNote=Connecting peptide
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415649+18112_2030801.6666666666666RegionNote=Alpha-2
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415649+18204_2950801.6666666666666RegionNote=Alpha-3
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415649+1822_1110801.6666666666666RegionNote=Alpha-1
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415649+18296_3050801.6666666666666RegionNote=Connecting peptide
HgeneHLA-Echr6:30457673chr5:137848637ENST00000427936+18112_2030801.6666666666666RegionNote=Alpha-2
HgeneHLA-Echr6:30457673chr5:137848637ENST00000427936+18204_2950801.6666666666666RegionNote=Alpha-3
HgeneHLA-Echr6:30457673chr5:137848637ENST00000427936+1822_1110801.6666666666666RegionNote=Alpha-1
HgeneHLA-Echr6:30457673chr5:137848637ENST00000427936+18296_3050801.6666666666666RegionNote=Connecting peptide
HgeneHLA-Echr6:30457673chr5:137848637ENST00000383597+1822_3050801.6666666666666Topological domainExtracellular
HgeneHLA-Echr6:30457673chr5:137848637ENST00000383597+18330_3580801.6666666666666Topological domainCytoplasmic
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415289+1822_3050801.6666666666666Topological domainExtracellular
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415289+18330_3580801.6666666666666Topological domainCytoplasmic
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415649+1822_3050801.6666666666666Topological domainExtracellular
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415649+18330_3580801.6666666666666Topological domainCytoplasmic
HgeneHLA-Echr6:30457673chr5:137848637ENST00000427936+1822_3050801.6666666666666Topological domainExtracellular
HgeneHLA-Echr6:30457673chr5:137848637ENST00000427936+18330_3580801.6666666666666Topological domainCytoplasmic
HgeneHLA-Echr6:30457673chr5:137848637ENST00000383597+18306_3290801.6666666666666TransmembraneHelical
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415289+18306_3290801.6666666666666TransmembraneHelical
HgeneHLA-Echr6:30457673chr5:137848637ENST00000415649+18306_3290801.6666666666666TransmembraneHelical
HgeneHLA-Echr6:30457673chr5:137848637ENST00000427936+18306_3290801.6666666666666TransmembraneHelical
TgeneETF1chr6:30457673chr5:137848637ENST0000036054141161_64180438.0MotifNIKS motif%3B plays an important role in translational termination


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Fusion Gene Sequence for HLA-E-ETF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36702_36702_1_HLA-E-ETF1_HLA-E_chr6_30457673_ENST00000376630_ETF1_chr5_137848637_ENST00000360541_length(transcript)=3207nt_BP=228nt
ACGACTCCCGACTATAAAGTCCCCATCCGGACTCAAGAAGTTCTCAGGACTCAGAGGCTGGGATCATGGTAGATGGAACCCTCCTTTTAC
TCCTCTCGGAGGCCCTGGCCCTTACCCAGACCTGGGCGGAGTATTGGGACCGGGAGACACGGAGCGCCAGGGACACCGCACAGATTTTCC
GAGTGAATCTGCGGACGCTGCGCGGCTACTACAATCAGAGCGAGGCCGGTAGAGGAGGTCAGTCAGCCTTGCGTTTTGCCCGTTTAAGAA
TGGAAAAGCGACATAACTATGTTCGGAAAGTAGCAGAGACTGCTGTGCAGCTGTTTATTTCTGGGGACAAAGTGAATGTGGCTGGTCTAG
TTTTAGCTGGATCCGCTGACTTTAAAACTGAACTAAGTCAATCTGATATGTTTGATCAGAGGTTACAATCAAAAGTTTTAAAATTAGTTG
ATATATCCTATGGTGGTGAAAATGGATTCAACCAAGCTATTGAGTTATCTACTGAAGTCCTCTCCAACGTGAAATTCATTCAAGAGAAGA
AATTAATAGGACGATACTTTGATGAAATCAGCCAGGACACGGGCAAGTACTGTTTTGGCGTTGAAGATACACTAAAGGCTTTGGAAATGG
GAGCTGTAGAAATTCTAATAGTCTATGAAAATCTGGATATAATGAGATATGTTCTTCATTGCCAAGGCACAGAAGAGGAGAAAATTCTCT
ATCTAACTCCAGAGCAAGAAAAGGATAAATCTCATTTCACAGACAAAGAGACCGGACAGGAACATGAGCTTATCGAGAGCATGCCCCTGT
TGGAATGGTTTGCTAACAACTATAAAAAATTTGGAGCTACGTTGGAAATTGTCACAGATAAATCACAAGAAGGGTCTCAGTTTGTGAAAG
GATTTGGTGGAATTGGAGGTATCTTGCGGTACCGAGTAGATTTCCAGGGAATGGAATACCAAGGAGGAGACGATGAATTTTTTGACCTTG
ATGACTACTAGGTAGTCGACATGGGTCCGGCAAAACGTGCCTCACCCTCCAGCATCCAACCCAAGGAGCATACCCATGGTGGAATCCAAA
CAGATCCCTGCCTTACAATTGGAACATTTCCAGAACTTAATCCATGAGCATTGGATATTGAAAAGAAAACCGAAACAAAACCAGACCCAG
CCCTACACTTTGGTTTGTCATGGTGTCAGCGCAGCAGCCTACAACTAAGTTCCTAAACGCCACTTTGGACTAATTTAAAAAAGAATCCCA
GTTTTTACTTTTACTGGATGGTGAAATTGGTTGCTCTTGTATTTTATGAAAAAAAATGATTTTTTTAACCTTCATACATAGAAGCAAAAA
TACTTTAACTGCTGTAAACCTTCAAAAGTTAATAGAAGTGAGATCATACTGGTTTGTTTCTTATTTTGATTGGAGAAAAATTAAATTGCT
GCATTTCGCAGTGACCCATTTACATGGCATTCTCAGCTTAGACTGCGTAAGAAGAAATATATGTGGTGAAATGTTGGAACCATTTCTCTC
TTGGTCTCTGTTTAATGTTGAAAGGGTGAGCTAATAGGAGGCACTTTCAACTTCACTCCCTCACGCTACCCCGTCCCCCTCCAGACTGGC
AGTTTCAAGGATGCAAATTGCATTGCAAAATCAAACTGACTCATGAAGCATTTGGGCCAGTGCACTGTTTACTTCCATCTGTTTGCAGAC
ACATTTGTGCCCGGCGTTTGGGAGCCCTTTGTATCAATGTTCTGACAAGGGTCCCTATAACCTTAACCTACTCGAAACCGGTTTGGGATG
GATATGATGGGGCTTCTGTGCTATTGCTGGGATTGGGAGAAATAAAACATGCAATTTAAGTGGAAGCGAAGAAATTTAAAGAGGATTTTA
TTTTGCTTGGGTCAATCCTTGTTAAAAGGGAGGTGGATGTGTTTTCCTTGTGTTGGATGGCATGAGATTATGTGAATGTTTTGATTTATT
AAAATGAACTGCAAGGTTTTTCACAGGAACGACAGACATGTATGACTGCATGTAATTATAAACTCCTGACCTCCTGGTGGGGTTGGAGCA
TCTGTTTCAAATGTGGGACTTACAAGCACTTCTCACATGAGAAATTAGGGGCGGGTGGGAAGGGATGGGACACAGCTTCTGGCACCATGG
ATTTAAGACCATGTTGGATCCAAAAGTTGGCCTGAAACCCTGAAGCTTATGCTTCACAGCTGGGCTGTAAGTCAGACTTGAACCCAGCTG
ATATGCAAGGTCATGGCGTGCCCAGGGTGGTGACAGTTGAACAAAGTGTATAGTACGTGCCCAGTGGTAGCGATGGAAAAAAGTATACCA
AATGGACTTTGAAGGACCAAAGGTTTTAAAAGTCAATTGGTATCACCTCCACACTGACTAGGGTAGTGGGGTGCATTTGGTTTTCAAATT
GGGTACTTTTAACACTTTAGTGCCTGACTGCTGTTCTTTACTGACTTGATTCAGTCACTCGTAGCTTTATTGGTCTGAACCAGCTCCTTG
TTCCCAGGTTACAGACCTGCCTATCGTTCCAATAATCCTGTTTCACTTGAATGAAGGGAGTATGTCTTAAATGTAAAGTTTCTGGTTCTC
ACACTGTACTCTGAGGTCCAAATACTGTCTGTCAATGTGTAACCTGATGTCTCAACCCCCTGTGAGAAGAGTCCATTATTTGGTGTTCAC
CAACGTGGGAGACTTCACCGGAACAGGCTTTTTTGCTTTGGGCTCTGCTATTTGTTTGCAGAACACCCAAGAGCGAGCAAACATGCTCTC
TTCACAGCAGTACCTTAGGGTTTTGCCATTGTAAATGGGTCTGATGTGATATGACAAGACCAGAGAAATTGGATGTAAATTTACATTTTT
GAATATGCTTGTTGTTTCACATGATACATTTAGGGTATGCAGCTCCTTTTGTAGTTTTTATTTTTACTATTTAAGTTTGGAAATGATGCC
AAATTTTTGTATTTCTTTAATCAATGTGTTCTCTTCGGTGATATATATTGCATTATATATTGATGTGTGTATCAATATATATTGATATGT
ATTACACTTACACATACAAACACATATAAGAGGGGGTGAAAACCGTAGCCTTTGCATTCTCTATAGCCTCTGCAGAGAGATACTAAGCAG

>36702_36702_1_HLA-E-ETF1_HLA-E_chr6_30457673_ENST00000376630_ETF1_chr5_137848637_ENST00000360541_length(amino acids)=311AA_BP=54
MVDGTLLLLLSEALALTQTWAEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISG
DKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVE
DTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSHFTDKETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKS

--------------------------------------------------------------
>36702_36702_2_HLA-E-ETF1_HLA-E_chr6_30457673_ENST00000376630_ETF1_chr5_137848637_ENST00000499810_length(transcript)=3211nt_BP=228nt
ACGACTCCCGACTATAAAGTCCCCATCCGGACTCAAGAAGTTCTCAGGACTCAGAGGCTGGGATCATGGTAGATGGAACCCTCCTTTTAC
TCCTCTCGGAGGCCCTGGCCCTTACCCAGACCTGGGCGGAGTATTGGGACCGGGAGACACGGAGCGCCAGGGACACCGCACAGATTTTCC
GAGTGAATCTGCGGACGCTGCGCGGCTACTACAATCAGAGCGAGGCCGGTAGAGGAGGTCAGTCAGCCTTGCGTTTTGCCCGTTTAAGAA
TGGAAAAGCGACATAACTATGTTCGGAAAGTAGCAGAGACTGCTGTGCAGCTGTTTATTTCTGGGGACAAAGTGAATGTGGCTGGTCTAG
TTTTAGCTGGATCCGCTGACTTTAAAACTGAACTAAGTCAATCTGATATGTTTGATCAGAGGTTACAATCAAAAGTTTTAAAATTAGTTG
ATATATCCTATGGTGGTGAAAATGGATTCAACCAAGCTATTGAGTTATCTACTGAAGTCCTCTCCAACGTGAAATTCATTCAAGAGAAGA
AATTAATAGGACGATACTTTGATGAAATCAGCCAGGACACGGGCAAGTACTGTTTTGGCGTTGAAGATACACTAAAGGCTTTGGAAATGG
GAGCTGTAGAAATTCTAATAGTCTATGAAAATCTGGATATAATGAGATATGTTCTTCATTGCCAAGGCACAGAAGAGGAGAAAATTCTCT
ATCTAACTCCAGAGCAAGAAAAGGATAAATCTCATTTCACAGACAAAGAGACCGGACAGGAACATGAGCTTATCGAGAGCATGCCCCTGT
TGGAATGGTTTGCTAACAACTATAAAAAATTTGGAGCTACGTTGGAAATTGTCACAGATAAATCACAAGAAGGGTCTCAGTTTGTGAAAG
GATTTGGTGGAATTGGAGGTATCTTGCGGTACCGAGTAGATTTCCAGGGAATGGAATACCAAGGAGGAGACGATGAATTTTTTGACCTTG
ATGACTACTAGGTAGTCGACATGGGTCCGGCAAAACGTGCCTCACCCTCCAGCATCCAACCCAAGGAGCATACCCATGGTGGAATCCAAA
CAGATCCCTGCCTTACAATTGGAACATTTCCAGAACTTAATCCATGAGCATTGGATATTGAAAAGAAAACCGAAACAAAACCAGACCCAG
CCCTACACTTTGGTTTGTCATGGTGTCAGCGCAGCAGCCTACAACTAAGTTCCTAAACGCCACTTTGGACTAATTTAAAAAAGAATCCCA
GTTTTTACTTTTACTGGATGGTGAAATTGGTTGCTCTTGTATTTTATGAAAAAAAATGATTTTTTTAACCTTCATACATAGAAGCAAAAA
TACTTTAACTGCTGTAAACCTTCAAAAGTTAATAGAAGTGAGATCATACTGGTTTGTTTCTTATTTTGATTGGAGAAAAATTAAATTGCT
GCATTTCGCAGTGACCCATTTACATGGCATTCTCAGCTTAGACTGCGTAAGAAGAAATATATGTGGTGAAATGTTGGAACCATTTCTCTC
TTGGTCTCTGTTTAATGTTGAAAGGGTGAGCTAATAGGAGGCACTTTCAACTTCACTCCCTCACGCTACCCCGTCCCCCTCCAGACTGGC
AGTTTCAAGGATGCAAATTGCATTGCAAAATCAAACTGACTCATGAAGCATTTGGGCCAGTGCACTGTTTACTTCCATCTGTTTGCAGAC
ACATTTGTGCCCGGCGTTTGGGAGCCCTTTGTATCAATGTTCTGACAAGGGTCCCTATAACCTTAACCTACTCGAAACCGGTTTGGGATG
GATATGATGGGGCTTCTGTGCTATTGCTGGGATTGGGAGAAATAAAACATGCAATTTAAGTGGAAGCGAAGAAATTTAAAGAGGATTTTA
TTTTGCTTGGGTCAATCCTTGTTAAAAGGGAGGTGGATGTGTTTTCCTTGTGTTGGATGGCATGAGATTATGTGAATGTTTTGATTTATT
AAAATGAACTGCAAGGTTTTTCACAGGAACGACAGACATGTATGACTGCATGTAATTATAAACTCCTGACCTCCTGGTGGGGTTGGAGCA
TCTGTTTCAAATGTGGGACTTACAAGCACTTCTCACATGAGAAATTAGGGGCGGGTGGGAAGGGATGGGACACAGCTTCTGGCACCATGG
ATTTAAGACCATGTTGGATCCAAAAGTTGGCCTGAAACCCTGAAGCTTATGCTTCACAGCTGGGCTGTAAGTCAGACTTGAACCCAGCTG
ATATGCAAGGTCATGGCGTGCCCAGGGTGGTGACAGTTGAACAAAGTGTATAGTACGTGCCCAGTGGTAGCGATGGAAAAAAGTATACCA
AATGGACTTTGAAGGACCAAAGGTTTTAAAAGTCAATTGGTATCACCTCCACACTGACTAGGGTAGTGGGGTGCATTTGGTTTTCAAATT
GGGTACTTTTAACACTTTAGTGCCTGACTGCTGTTCTTTACTGACTTGATTCAGTCACTCGTAGCTTTATTGGTCTGAACCAGCTCCTTG
TTCCCAGGTTACAGACCTGCCTATCGTTCCAATAATCCTGTTTCACTTGAATGAAGGGAGTATGTCTTAAATGTAAAGTTTCTGGTTCTC
ACACTGTACTCTGAGGTCCAAATACTGTCTGTCAATGTGTAACCTGATGTCTCAACCCCCTGTGAGAAGAGTCCATTATTTGGTGTTCAC
CAACGTGGGAGACTTCACCGGAACAGGCTTTTTTGCTTTGGGCTCTGCTATTTGTTTGCAGAACACCCAAGAGCGAGCAAACATGCTCTC
TTCACAGCAGTACCTTAGGGTTTTGCCATTGTAAATGGGTCTGATGTGATATGACAAGACCAGAGAAATTGGATGTAAATTTACATTTTT
GAATATGCTTGTTGTTTCACATGATACATTTAGGGTATGCAGCTCCTTTTGTAGTTTTTATTTTTACTATTTAAGTTTGGAAATGATGCC
AAATTTTTGTATTTCTTTAATCAATGTGTTCTCTTCGGTGATATATATTGCATTATATATTGATGTGTGTATCAATATATATTGATATGT
ATTACACTTACACATACAAACACATATAAGAGGGGGTGAAAACCGTAGCCTTTGCATTCTCTATAGCCTCTGCAGAGAGATACTAAGCAG

>36702_36702_2_HLA-E-ETF1_HLA-E_chr6_30457673_ENST00000376630_ETF1_chr5_137848637_ENST00000499810_length(amino acids)=311AA_BP=54
MVDGTLLLLLSEALALTQTWAEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISG
DKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVE
DTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSHFTDKETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKS

--------------------------------------------------------------
>36702_36702_3_HLA-E-ETF1_HLA-E_chr6_30457673_ENST00000376630_ETF1_chr5_137848637_ENST00000503014_length(transcript)=1316nt_BP=228nt
ACGACTCCCGACTATAAAGTCCCCATCCGGACTCAAGAAGTTCTCAGGACTCAGAGGCTGGGATCATGGTAGATGGAACCCTCCTTTTAC
TCCTCTCGGAGGCCCTGGCCCTTACCCAGACCTGGGCGGAGTATTGGGACCGGGAGACACGGAGCGCCAGGGACACCGCACAGATTTTCC
GAGTGAATCTGCGGACGCTGCGCGGCTACTACAATCAGAGCGAGGCCGGTAGAGGAGGTCAGTCAGCCTTGCGTTTTGCCCGTTTAAGAA
TGGAAAAGCGACATAACTATGTTCGGAAAGTAGCAGAGACTGCTGTGCAGCTGTTTATTTCTGGGGACAAAGTGAATGTGGCTGGTCTAG
TTTTAGCTGGATCCGCTGACTTTAAAACTGAACTAAGTCAATCTGATATGTTTGATCAGAGGTTACAATCAAAAGTTTTAAAATTAGTTG
ATATATCCTATGGTGGTGAAAATGGATTCAACCAAGCTATTGAGTTATCTACTGAAGTCCTCTCCAACGTGAAATTCATTCAAGAGAAGA
AATTAATAGGACGATACTTTGATGAAATCAGCCAGGACACGGGCAAGTACTGTTTTGGCGTTGAAGATACACTAAAGGCTTTGGAAATGG
GAGCTGTAGAAATTCTAATAGTCTATGAAAATCTGGATATAATGAGATATGTTCTTCATTGCCAAGGCACAGAAGAGGAGAAAATTCTCT
ATCTAACTCCAGAGCAAGAAAAGGATAAATCTCATTTCACAGACAAAGAGACCGGACAGGAACATGAGCTTATCGAGAGCATGCCCCTGT
TGGAATGGTTTGCTAACAACTATAAAAAATTTGGAGCTACGTTGGAAATTGTCACAGATAAATCACAAGAAGGGTCTCAGTTTGTGAAAG
GATTTGGTGGAATTGGAGGTATCTTGCGGTACCGAGTAGATTTCCAGGGAATGGAATACCAAGGAGGAGACGATGAATTTTTTGACCTTG
ATGACTACTAGGTAGTCGACATGGGTCCGGCAAAACGTGCCTCACCCTCCAGCATCCAACCCAAGGAGCATACCCATGGTGGAATCCAAA
CAGATCCCTGCCTTACAATTGGAACATTTCCAGAACTTAATCCATGAGCATTGGATATTGAAAAGAAAACCGAAACAAAACCAGACCCAG
CCCTACACTTTGGTTTGTCATGGTGTCAGCGCAGCAGCCTACAACTAAGTTCCTAAACGCCACTTTGGACTAATTTAAAAAAGAATCCCA

>36702_36702_3_HLA-E-ETF1_HLA-E_chr6_30457673_ENST00000376630_ETF1_chr5_137848637_ENST00000503014_length(amino acids)=311AA_BP=54
MVDGTLLLLLSEALALTQTWAEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISG
DKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVE
DTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSHFTDKETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HLA-E-ETF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HLA-E-ETF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HLA-E-ETF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource