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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HMGCS1-UNC13A (FusionGDB2 ID:36923)

Fusion Gene Summary for HMGCS1-UNC13A

Fusion gene summary

Fusion gene information	Fusion gene name: HMGCS1-UNC13A
	Fusion gene ID: 36923
		Hgene	Tgene
	Gene symbol	HMGCS1	UNC13A
	Gene ID	3157	23025
	Gene name	3-hydroxy-3-methylglutaryl-CoA synthase 1	unc-13 homolog A
	Synonyms	HMGCS	Munc13-1
	Cytomap	5p12	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	hydroxymethylglutaryl-CoA synthase, cytoplasmic3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	protein unc-13 homolog A
	Modification date	20200313	20200313
	UniProtAcc	Q01581	.
	Ensembl transtripts involved in fusion gene	ENST00000325110, ENST00000433297,	ENST00000252773, ENST00000428389, ENST00000519716, ENST00000550896, ENST00000551649, ENST00000552293,
Fusion gene scores	* DoF score	9 X 13 X 5=585	11 X 13 X 6=858
	# samples	13	13
	** MAII score	log2(13/585*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/858*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HMGCS1 [Title/Abstract] AND UNC13A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HMGCS1(43292950)-UNC13A(17756920), # samples:3
Anticipated loss of major functional domain due to fusion event.	HMGCS1-UNC13A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. HMGCS1-UNC13A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. HMGCS1-UNC13A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	UNC13A	GO:1903861	positive regulation of dendrite extension	23999003

Fusion gene breakpoints across HMGCS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UNC13A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-FD-A62P-01A	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-
ChimerDB4	BLCA	TCGA-FD-A62P-01A	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-

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Fusion Gene ORF analysis for HMGCS1-UNC13A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000325110	ENST00000252773	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000325110	ENST00000428389	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000325110	ENST00000519716	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000325110	ENST00000550896	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000325110	ENST00000551649	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000325110	ENST00000552293	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000433297	ENST00000252773	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000433297	ENST00000252773	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000433297	ENST00000428389	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000433297	ENST00000428389	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000433297	ENST00000519716	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000433297	ENST00000519716	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000433297	ENST00000550896	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000433297	ENST00000550896	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000433297	ENST00000551649	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000433297	ENST00000551649	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000433297	ENST00000552293	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-
Frame-shift	ENST00000433297	ENST00000552293	HMGCS1	chr5	43292950	-	UNC13A	chr19	17756920	-
In-frame	ENST00000325110	ENST00000252773	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-
In-frame	ENST00000325110	ENST00000428389	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-
In-frame	ENST00000325110	ENST00000519716	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-
In-frame	ENST00000325110	ENST00000550896	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-
In-frame	ENST00000325110	ENST00000551649	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-
In-frame	ENST00000325110	ENST00000552293	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000325110	HMGCS1	chr5	43292576	-	ENST00000519716	UNC13A	chr19	17756920	-	9474	1680	1697	4747	1016
ENST00000325110	HMGCS1	chr5	43292576	-	ENST00000252773	UNC13A	chr19	17756920	-	9473	1680	1697	4747	1016
ENST00000325110	HMGCS1	chr5	43292576	-	ENST00000428389	UNC13A	chr19	17756920	-	9473	1680	1697	4747	1016
ENST00000325110	HMGCS1	chr5	43292576	-	ENST00000551649	UNC13A	chr19	17756920	-	5538	1680	1697	4804	1035
ENST00000325110	HMGCS1	chr5	43292576	-	ENST00000552293	UNC13A	chr19	17756920	-	4823	1680	1697	4729	1010
ENST00000325110	HMGCS1	chr5	43292576	-	ENST00000550896	UNC13A	chr19	17756920	-	4676	1680	1697	4672	991

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000325110	ENST00000519716	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-	0.001302383	0.99869764
ENST00000325110	ENST00000252773	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-	0.001300456	0.99869955
ENST00000325110	ENST00000428389	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-	0.001300408	0.99869955
ENST00000325110	ENST00000551649	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-	0.002925115	0.99707484
ENST00000325110	ENST00000552293	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-	0.002921589	0.9970784
ENST00000325110	ENST00000550896	HMGCS1	chr5	43292576	-	UNC13A	chr19	17756920	-	0.003054332	0.9969457

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Fusion Genomic Features for HMGCS1-UNC13A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HMGCS1-UNC13A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:43292950/chr19:17756920)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HMGCS1 Q01581	.
FUNCTION: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269\|PubMed:7913309}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HMGCS1

chr5:43292576

chr19:17756920

ENST00000325110

44_46

491

521.0

Region

Coenzyme A binding

Hgene

HMGCS1

chr5:43292576

chr19:17756920

ENST00000433297

44_46

491

521.0

Region

Coenzyme A binding

Tgene

UNC13A

chr5:43292576

chr19:17756920

ENST00000519716

1093_1236

681

1704.0

Domain

MHD1

Tgene

UNC13A

chr5:43292576

chr19:17756920

ENST00000519716

1345_1512

681

1704.0

Domain

MHD2

Tgene

UNC13A

chr5:43292576

chr19:17756920

ENST00000519716

1526_1653

681

1704.0

Domain

C2 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

UNC13A

chr5:43292576

chr19:17756920

ENST00000519716

320_357

681

1704.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

UNC13A

chr5:43292576

chr19:17756920

ENST00000519716

321_350

681

1704.0

Compositional bias

Note=Glu-rich

Tgene

UNC13A

chr5:43292576

chr19:17756920

ENST00000519716

1_97

681

1704.0

Domain

C2 1

Tgene

UNC13A

chr5:43292576

chr19:17756920

ENST00000519716

659_783

681

1704.0

Domain

C2 2

Tgene

UNC13A

chr5:43292576

chr19:17756920

ENST00000519716

553_603

681

1704.0

Zinc finger

Phorbol-ester/DAG-type

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Fusion Gene Sequence for HMGCS1-UNC13A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>36923_36923_1_HMGCS1-UNC13A_HMGCS1_chr5_43292576_ENST00000325110_UNC13A_chr19_17756920_ENST00000252773_length(transcript)=9473nt_BP=1680nt
GTCCCGCCTCCCAGCGACTCTCGGCGGTGCCGGAGTCGGGTGGGTTGGCGGCTATAAAGCTGGTGGCGAAGGGGAGGCGCCGCGGACTGT
CCTTTCGTGGCTCACTCCCTTTCCTCTGCTGCCGCTCGGTCACGCTTGTGCCCGAAGGAGGAAACAGTGACAGACCTGGAGACTGCAGTT
CTCTATCCTTCACACAGCTCTTTCACCATGCCTGGATCACTTCCTTTGAATGCAGAAGCTTGCTGGCCAAAAGATGTGGGAATTGTTGCC
CTTGAGATCTATTTTCCTTCTCAATATGTTGATCAAGCAGAGTTGGAAAAATATGATGGTGTAGATGCTGGAAAGTATACCATTGGCTTG
GGCCAGGCCAAGATGGGCTTCTGCACAGATAGAGAAGATATTAACTCTCTTTGCATGACTGTGGTTCAGAATCTTATGGAGAGAAATAAC
CTTTCCTATGATTGCATTGGGCGGCTGGAAGTTGGAACAGAGACAATCATCGACAAATCAAAGTCTGTGAAGACTAATTTGATGCAGCTG
TTTGAAGAGTCTGGGAATACAGATATAGAAGGAATCGACACAACTAATGCATGCTATGGAGGCACAGCTGCTGTCTTCAATGCTGTTAAC
TGGATTGAGTCCAGCTCTTGGGATGGACGGTATGCCCTGGTAGTTGCAGGAGATATTGCTGTATATGCCACAGGAAATGCTAGACCTACA
GGTGGAGTTGGAGCAGTAGCTCTGCTAATTGGGCCAAATGCTCCTTTAATTTTTGAACGAGGGCTTCGTGGGACACATATGCAACATGCC
TATGATTTTTACAAGCCTGATATGCTATCTGAATATCCTATAGTAGATGGAAAACTCTCCATACAGTGCTACCTCAGTGCATTAGACCGC
TGCTATTCTGTCTACTGCAAAAAGATCCATGCCCAGTGGCAGAAAGAGGGAAATGATAAAGATTTTACCTTGAATGATTTTGGCTTCATG
ATCTTTCACTCACCATATTGTAAACTGGTTCAGAAATCTCTAGCTCGGATGTTGCTGAATGACTTCCTTAATGACCAGAATAGAGATAAA
AATAGTATCTATAGTGGCCTGGAAGCCTTTGGGGATGTTAAATTAGAAGACACCTACTTTGATAGAGATGTGGAGAAGGCATTTATGAAG
GCTAGCTCTGAACTCTTCAGTCAGAAAACAAAGGCATCTTTACTTGTATCAAATCAAAATGGAAATATGTACACATCTTCAGTATATGGT
TCCCTTGCATCTGTTCTAGCACAGTACTCACCTCAGCAATTAGCAGGGAAGAGAATTGGAGTGTTTTCTTATGGTTCTGGTTTGGCTGCC
ACTCTGTACTCTCTTAAAGTCACACAAGATGCTACACCGGGGTCTGCTCTTGATAAAATAACAGCAAGTTTATGTGATCTTAAATCAAGG
CTTGATTCAAGAACTGGTGTGGCACCAGATGTCTTCGCTGAAAACATGAAGCTCAGAGAGGACACCCATCATTTGGTCAACTATATTCCC
CAGGGTTCAATAGATTCACTCTTTGAAGGAACGTGGTACTTAGTTAGGGTGGATGAAAAGCACAGAAGAACTTACGCTCGGCGTCCCACT
CCAAATGATGACACTTTGGATGAAGGAGTAGGACTTGTGCATTCAAACATAGCAACTGAGTGGTCTGCGCCCAGGGCTTGCAGGCAAAGG
ACAAGACAGGATCCAGTGACCCCTATGTCACCGTCCAGGTCGGGAAGACCAAGAAACGGACAAAAACCATCTATGGGAACCTCAACCCGG
TGTGGGAGGAGAATTTCCACTTTGAATGTCACAATTCCTCCGACCGCATCAAGGTGCGCGTCTGGGACGAGGATGACGACATCAAATCCC
GCGTGAAACAGAGGTTCAAGAGGGAATCTGACGATTTCCTGGGGCAGACGATCATTGAGGTGCGGACGCTCAGCGGCGAGATGGACGTGT
GGTACAACCTGGACAAGCGAACTGACAAATCTGCCGTGTCGGGTGCCATCCGGCTCCACATCAGTGTGGAGATCAAAGGCGAGGAGAAGG
TGGCCCCGTACCATGTCCAGTACACCTGTCTGCATGAGAACCTGTTCCACTTCGTGACCGACGTGCAGAACAATGGGGTCGTGAAGATCC
CAGATGCCAAGGGTGACGATGCCTGGAAGGTTTACTACGATGAGACAGCCCAGGAGATTGTGGACGAGTTTGCCATGCGCTACGGCGTCG
AGTCCATCTACCAAGCCATGACCCACTTTGCCTGCCTCTCCTCCAAGTATATGTGCCCAGGGGTGCCTGCCGTCATGAGCACCCTGCTCG
CCAACATCAATGCCTACTACGCACACACCACCGCCTCCACCAACGTGTCTGCCTCCGACCGCTTCGCCGCCTCCAACTTTGGGAAAGAGC
GCTTCGTGAAACTCCTGGACCAGCTGCATAACTCCCTGCGGATTGACCTCTCCATGTACCGGAATAACTTCCCAGCCAGCAGCCCGGAGA
GACTCCAGGACCTCAAATCCACTGTGGACCTTCTCACCAGCATCACCTTCTTTCGGATGAAGGTACAAGAACTCCAGAGCCCGCCCCGAG
CCAGCCAGGTGGTAAAGGACTGTGTGAAAGCCTGCCTTAATTCTACCTACGAGTACATCTTCAATAACTGCCATGAACTGTACAGCCGGG
AGTACCAGACAGACCCGGCCAAGAAGGGGGAAGTTCTCCCAGAGGAACAGGGGCCCAGCATCAAGAACCTCGACTTCTGGTCCAAGCTGA
TTACCCTCATAGTGTCCATCATTGAGGAAGACAAGAATTCCTACACTCCCTGCCTCAACCAGTTTCCCCAGGAGCTGAATGTGGGTAAAA
TCAGCGCTGAAGTGATGTGGAATCTGTTTGCCCAAGACATGAAGTACGCCATGGAGGAGCACGACAAGCATCGTCTATGCAAGAGTGCCG
ACTACATGAACCTCCACTTCAAGGTGAAATGGCTCTACAATGAGTATGTGACGGAACTTCCCGCCTTCAAGGACCGCGTGCCTGAGTACC
CTGCATGGTTTGAACCCTTCGTCATCCAGTGGCTGGATGAGAATGAGGAGGTGTCCCGGGATTTCCTGCACGGTGCCCTGGAGCGAGACA
AGAAGGATGGGTTCCAGCAGACCTCAGAGCATGCCCTATTCTCCTGCTCCGTGGTGGATGTTTTCTCCCAACTCAACCAGAGCTTTGAAA
TCATCAAGAAACTCGAGTGTCCCGACCCTCAGATCGTGGGGCACTACATGAGGCGCTTTGCCAAGACCATCAGTAATGTGCTCCTCCAGT
ATGCAGACATCATCTCCAAGGACTTTGCCTCCTACTGCTCCAAGGAGAAGGAGAAAGTGCCCTGCATTCTCATGAATAACACTCAACAGC
TACGAGTTCAGCTGGAGAAGATGTTCGAAGCCATGGGAGGAAAGGAGCTGGATGCTGAAGCCAGTGACATCCTGAAGGAGCTTCAGGTGA
AACTCAATAACGTCTTGGATGAGCTCAGCCGGGTGTTTGCTACCAGCTTCCAGCCGCACATTGAAGAGTGTGTCAAACAGATGGGTGACA
TCCTTAGCCAGGTTAAGGGCACAGGCAATGTGCCAGCCAGTGCCTGCAGCAGCGTGGCCCAGGACGCGGACAATGTGTTGCAGCCCATCA
TGGACCTGCTGGACAGCAACCTGACCCTCTTTGCCAAAATCTGTGAGAAGACTGTGCTGAAGCGAGTGCTGAAGGAGCTGTGGAAGCTGG
TTATGAACACCATGGAGAAAACCATCGTCCTGCCGCCCCTCACTGACCAGACGCTGCAGGGGAACCTCTTGAGAAAACATGGCAAGGGAT
TAGAAAAGGGCAGGGTGAAATTGCCAAGCCACTCAGACGGAACCCAGATGATCTTCAATGCAGCCAAGGAGCTGGGTCAGCTGTCCAAAC
TCAAGGATCACATGGTACGAGAAGAAGCCAAGAGCTTGACCCCAAAGCAGTGCGCGGTTGTTGAGTTGGCCCTGGACACCATCAAGCAAT
ATTTCCACGCGGGTGGCGTGGGCCTCAAGAAGACCTTCCTGGAGAAGAGCCCGGACCTGCAATCCTTGCGCTATGCCCTGTCGCTCTACA
CGCAGGCCACCGACCTGCTAATCAAGACCTTTGTACAGACGCAATCGGCCCAGGGCTTGGGTGTAGAAGACCCTGTGGGTGAAGTCTCTG
TCCATGTTGAGCTGTTCACTCATCCAGGAACTGGGGAACACAAGGTCACAGTGAAAGTGGTGGCTGCCAATGACCTCAAGTGGCAGACTT
CTGGCATCTTCCGGCCGTTCATCGAGGTCAACATCATTGGGCCCCAGCTCAGCGACAAGAAACGCAAGTTTGCGACCAAATCCAAGAACA
ATAGCTGGGCTCCCAAGTACAATGAGAGCTTCCAGTTCACGCTGAGCGCCGACGCGGGTCCCGAGTGCTATGAGCTGCAGGTGTGCGTCA
AGGACTACTGCTTCGCGCGCGAGGACCGCACGGTGGGGCTGGCCGTGCTGCAGCTGCGTGAGCTGGCCCAGCGCGGGAGCGCCGCCTGCT
GGCTGCCGCTCGGCCGCCGCATCCACATGGACGACACGGGCCTCACGGTGCTGCGAATCCTCTCGCAGCGCAGCAACGACGAGGTGGCCA
AGGAGTTCGTGAAGCTCAAGTCGGACACGCGCTCCGCCGAGGAGGGCGGTGCCGCGCCTGCGCCTTAGCGCGGGCGGTCGGCCGAGCGGC
ACTGCGCCTGCGCGGAGGGCGCTGGGCGGGGAGGGACGGGGCTTGCGCCTTGGTGGGACCTCCCCAGGGGCGGGGCTCGGGGGGCTCCAC
GCCAAGGGTGGGCTGCGCCTACGCCCTTGACTCAGCTTTCCCTTTTGGGGAATTAGGAATGGAGGATGCCCCGCCCTCTCGGGAGGCCAC
GCCCAAGGGCGCGACGAAGGAAGGAGCCACATCCCCAACTTGAGGCCACGCCCCCAGCACCTAGGGGGCATTTTGAGCTGGGATGGGGGA
AACCTCGTCCCTATGGAGGAGGCCACATCCCGGGGCTCTGGTACCGGGAGGCACCACCTCATGTCCCCTGGAAAAGCCATAAGATGGGAC
CCAGACCCCTGGGACCCCAGACCAATTGCCAAGTATGGAAATCTCAGCTCCCTCGAGGGGGGGCCCTGGGCAAGGGGTAGGGCTCTCTGG
AGCGCCCCTCTAGGTGGCCTGGGGACTGGAGGGACCAGGATGCTGGTTGGAGGGCCCCGGAATACCGGAGTCCCTTTAGATATTTGTGCA
AAAAATAAATGGGGGGAGGGGGGAGGATGGGATTTCAAAAGCACATGCGCCCTTGGGCGCCCAAACCCTGGGGGCCGAGGGGACGGCTCT
GGTTCCCCACGCTGCCCCTACTTCCCTTTGGGAGTTTGCCTCTCCCTCTCCCCCAACAAACCCAGTCCTCATATCATAGAGTTCAACACA
CCCATTTGACAGATGGCAAAACTGAGGCTTAAAGAGCTGCTTGAGACTTGGCCAAGGTTCCAGGTGCCATACCCTCTGTGCCCCTCCCTT
AGGCCTGTGTGCCCCATGGAAGGGTGGGCTGAGATCGGGATGACCTGACACAGCTCCCTATTGCTGCTAATTCCCCCTCGGCCTCCTCCA
AGGGGTGGGAATTCCAGGCCAAGACCCCTACTTCGCCTTTCCTTCTCCGGCTGCCAAGCAGGACCTTTGCCCTCAGCCCTTTCTCCTGGG
ATCTCCATGGGGGATGCCATGAGGGCCTCCCACCACAAAAGAGAATTTGGGATCCCCTGGTCCCAGGTTTCTCCATCCCTTCTTCCTTTT
CCAGAATTTTCCAAATAGGAAAGAACAGAAGGAGACCAGAAACTCTAGGGGGGAGAAAGAGAATGAGAGAAAGAGAATGAGAGAGAGAGA
AACACAAACACAGTGACACAGTGAGAGCTTAGTCTCCAAGAGCCTATTCATTGATTCAAACACCCAAGCCACAGGATACCTCAGATGGCC
CTCTTGCCAGCTGGAAGCTCTTTCTCCAATGAGCAAAGTTACAGTGACCTGGCTGGAGTTACCTGGTGCACATAGGACCTTAGGGGAAAG
TTCAGCGTGGACTACACTTGCTCTGGGATCTGCTTTTCCACATGTGTGTATGGCACGCCTTTTTCTGCTGGATTGGGAAGGACAAGATTT
TGCTGTGCTAGGGAGAAATGAAAACGGGGTGAGCTGAGTAGCTGGGTTTCTGGAGGATAGAACATCAGATGGGGAGGCTTTCCGAGGTGA
AGAATGAGAGGGAACCACTTACTAGAGAGAAAAGAGCTCCAGGCCTGGGGAACAGCACGTGCGAAGGCCAGGAGAGAAGAACTGTTGAAA
CAACGAGAAGGGTGGCACGGCTGGAGCTGAGCCAGCAAGGGGGATCGTGAGGAGCCTTGGGGTTGGGGAGATCTGCAGAAGCATCAGACC
AGGCAGGGCCTCGTACGCAGTCCTGAGGAGTTTTACTTTTATTCTAAGACAGTTGGGGAGCTCCAGGAGCTGTTTTAAGTTGGGGAGAGA
CTGGATTCCAGCCTGCAAAAGCTGTTTTGTGAAGACTAAAACCAGTGAGGAGAGGTGGAGGTGCTTTGGGGACACTGAAATGGATTCTTG
GAAAGATTCTGAAGGCTGTGTTGAAAAGACACCTATAGCTGTGGGGACATGACTATAATCCCAGCATTTGGGGAGACCGAGGCTGGCAGA
TCACTTAAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTGCTAAAAATACAAAAATTAGCTGGGTGCAGTGG
TGCATGCCTGTAGTCCCAGCTACTCAGGAGACTGAGGCGGGAGAATTGTTTGAACCCTGGAGGCAGAGGTTGTAGTGAGTCGTGATCACA
CAACTGCACTCCAGCCTGGGCAACAGAACAATACTCCATTCCCTCCCCTCTACCCCACCAAAAAAAAAAAAAAATCCTGCCCTTAGATGA
GCTCTAGGGCTGCTGAGTACAGTTGTCCCAGTTGCACAGTGCCCAAGGGTTTGGCATTGCTAAGAAGGCCACGTGCAAATCCTAGATATT
GAGTGTTGTATGTTTGTGACGTTGGTTTCCCGACATGTGAATGGCCCAAGTGTCTGGAAGAAGTGGCGCCACTTTCTAATTTGCTTGGAG
ATGTTGCATGTCCCTTAAATTCAGACAGGTGCAGGTAACTGGAGGTTCTGAACCAAAGGTTAAAATGCAAATTCTCATACAGGGTTGGGA
AGTTGTAGCCAGGGATAAGCTTATGTGACTGTTATATGGACTGAGGAGCAGATGTGAATTTCGAACCATGACATGGCTGAGGGTAGGGGT
CGGGTGGATGGATGATTCAGGGTTGTAACCCATAGAGCCCAAAGGGGAAGTGATCTGTGACCTGGGGTGAGGGTGATCTGGAAGATTTTT
GGATGGCTGGAAAGAAATGGGGAAGTCGAGCTGCCTGAGAGAGCCAAGTTATTTCCCAAAAGATTCCTTAGGAGTCTTTCTGTTCAAGAC
CTCCGTGTGTGTGTGTGTGTGTTTAGGGTTCCCCAGCAATGGCCCAGGCATGTGAAGGAAACAAGCTTCTTCAGGGAATATTTGTTGAAT
GAGTTTTCCTGACTCCCAGGCTAGAACTGTTTTTGCAATTTCCACCCTCTTTTCTTTCCCCCAGAGAACTCCTATTCGTCCTTCAAAACC
CATCACGGAAACCCCTCTTGGAGAAAACCCTCCTTCCTTCCCCTCAGGACTTTCCCAGCCACCGTCTCTCCTCCAGTCCAGCCTGATGCC
ATGGGACTGGGGGTTTCTCTGTCCAGCTCTGTTTCTCCCAGACTGGGGTCTGAGGACTCTCAGGACCCCCAACTTTACCTAGCACAGGCT
GGGCACAAGTGGGTGACAGGGAGTCTACGCCTAGTGGAATTATGTATTGGGGCAGGGTCAGTGTGAGAATACACATCCGCATGCATGTCT
GTCCATGTCTGTCCGTACCAACCTTCCCCTTCCACACGGACCTGGGCACATAGGAGGTGTCTGAGCCTGACACATGGGACAGAGAGTGGA
CATGGCTGAGACACGGACAGAGAAAAGACAAGGAGTCCAGGGGGCTGAAAGCCTTTTGAAATCAGGAAGTTCCTGTATTGGCAGAACAAA
GCCCAGAGAGGAGCAGGGCTTTCCTCAACGCCACCCAGCAAGTGGACACAGAGCCCGGCCTTGGATGACACCTCCAGGGTTCTGAACCCT
GGACCTCGCTTTATGCAAGGAGCTGGCCCCACATTTCCATGAATCGGGGAAACAGCACAAGAAGGTTGGCCTGTGGCAGGGCAAGGGTTA
AAGGGGTGACATTGAGGGATGCCTCAGAGTCAAAGTCCCCTGACCAAGAGGAATAGAGTAGAAAACACAGAGACAGAGGGTGAGATCACG
CCCCGATGAGGACGGAGAGAGACAGAGATGGAGAGAGACATAGAGGTGGAAATATACAGAGAAAGATAAATGCAGAGACCAAGGCAGGGA
GTGTCGGGGGAAGTAAAGAGGGTGTCCTGAAGAAAGAAGGATCTGTTCACTCTTACCAGTCTGTCCTCGAATGATTTGCATAAAATGAGG
AGGTGCCTGTCCACACCCCCAATTCCTCTCTCAGGCCCCAGAGCCTGAGACCTCACCATGCCCCCATCAGAGATGCAAAAAACTAAACAC
CCAACTAGAAATCCTTGGGACCTCTCTCGGCTGGGATCTCAGAGCCTTTCTGTCCCCTACCCCTACCCCATGTGCTGTCGATTTTGCAGA
TGGGGACAACCTGGGGCCTCCCGGAACTCTGCCACCCTGGGGAAGTTGGGGGAGGGCCTTAGTCCCGGATCACAACCCCGTCTGCTCCCC
AGAATCCTTTCCTAAGAATCGTTGAGGACCAAAGTTGTCTTTGCTGACACGTGTTGCTTTTCTCTTTGCCTTTTATTGTTTCAGAGAAAA
ATCAAGTTGACTGTGTCAAGTAACACCCCACCCCTTACCCCCGTCCAGCCATAGTGGCTCTCTGGAGACACAGGTCACAGGCGGAGGGTC
CCCTGATCATCCCCAACCACACAGCCAGGGGGACTTGACCCCTGTCCACCCCTGTCTCGTGCTCCCTCAGACCCCCACAAACCGGCCAAG
CAGTCCGGGGAGGCTTCCCCTCCACACAACTCTTAGCATGTGATTGCAGATGTGAAATCAAAACGTTGTTTGTTTTTTGTTTTGTTTTGA
TTCTACCCCGTCGGTCCAGTGTCTGCACAGACGCCTTCATTTCTCTGTAAATATGTGACTTGGAACAAATGTTTAACACAAACGAGAAGT
GGTCATGAATGCATGGTGTTGAGATGTTTTGCACTATTCTGACTTTTTGGTCTCTGTAAAAATATTTTATTAACAGCAGACATTAAAAAA

>36923_36923_1_HMGCS1-UNC13A_HMGCS1_chr5_43292576_ENST00000325110_UNC13A_chr19_17756920_ENST00000252773_length(amino acids)=1016AA_BP=
MQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSG
EMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAM
RYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPA
SSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDF
WSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDR
VPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISN
VLLQYADIISKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVK
QMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTLQGNLLRK
HGKGLEKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYA
LSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSVHVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFAT
KSKNNSWAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSN

--------------------------------------------------------------
>36923_36923_2_HMGCS1-UNC13A_HMGCS1_chr5_43292576_ENST00000325110_UNC13A_chr19_17756920_ENST00000428389_length(transcript)=9473nt_BP=1680nt
GTCCCGCCTCCCAGCGACTCTCGGCGGTGCCGGAGTCGGGTGGGTTGGCGGCTATAAAGCTGGTGGCGAAGGGGAGGCGCCGCGGACTGT
CCTTTCGTGGCTCACTCCCTTTCCTCTGCTGCCGCTCGGTCACGCTTGTGCCCGAAGGAGGAAACAGTGACAGACCTGGAGACTGCAGTT
CTCTATCCTTCACACAGCTCTTTCACCATGCCTGGATCACTTCCTTTGAATGCAGAAGCTTGCTGGCCAAAAGATGTGGGAATTGTTGCC
CTTGAGATCTATTTTCCTTCTCAATATGTTGATCAAGCAGAGTTGGAAAAATATGATGGTGTAGATGCTGGAAAGTATACCATTGGCTTG
GGCCAGGCCAAGATGGGCTTCTGCACAGATAGAGAAGATATTAACTCTCTTTGCATGACTGTGGTTCAGAATCTTATGGAGAGAAATAAC
CTTTCCTATGATTGCATTGGGCGGCTGGAAGTTGGAACAGAGACAATCATCGACAAATCAAAGTCTGTGAAGACTAATTTGATGCAGCTG
TTTGAAGAGTCTGGGAATACAGATATAGAAGGAATCGACACAACTAATGCATGCTATGGAGGCACAGCTGCTGTCTTCAATGCTGTTAAC
TGGATTGAGTCCAGCTCTTGGGATGGACGGTATGCCCTGGTAGTTGCAGGAGATATTGCTGTATATGCCACAGGAAATGCTAGACCTACA
GGTGGAGTTGGAGCAGTAGCTCTGCTAATTGGGCCAAATGCTCCTTTAATTTTTGAACGAGGGCTTCGTGGGACACATATGCAACATGCC
TATGATTTTTACAAGCCTGATATGCTATCTGAATATCCTATAGTAGATGGAAAACTCTCCATACAGTGCTACCTCAGTGCATTAGACCGC
TGCTATTCTGTCTACTGCAAAAAGATCCATGCCCAGTGGCAGAAAGAGGGAAATGATAAAGATTTTACCTTGAATGATTTTGGCTTCATG
ATCTTTCACTCACCATATTGTAAACTGGTTCAGAAATCTCTAGCTCGGATGTTGCTGAATGACTTCCTTAATGACCAGAATAGAGATAAA
AATAGTATCTATAGTGGCCTGGAAGCCTTTGGGGATGTTAAATTAGAAGACACCTACTTTGATAGAGATGTGGAGAAGGCATTTATGAAG
GCTAGCTCTGAACTCTTCAGTCAGAAAACAAAGGCATCTTTACTTGTATCAAATCAAAATGGAAATATGTACACATCTTCAGTATATGGT
TCCCTTGCATCTGTTCTAGCACAGTACTCACCTCAGCAATTAGCAGGGAAGAGAATTGGAGTGTTTTCTTATGGTTCTGGTTTGGCTGCC
ACTCTGTACTCTCTTAAAGTCACACAAGATGCTACACCGGGGTCTGCTCTTGATAAAATAACAGCAAGTTTATGTGATCTTAAATCAAGG
CTTGATTCAAGAACTGGTGTGGCACCAGATGTCTTCGCTGAAAACATGAAGCTCAGAGAGGACACCCATCATTTGGTCAACTATATTCCC
CAGGGTTCAATAGATTCACTCTTTGAAGGAACGTGGTACTTAGTTAGGGTGGATGAAAAGCACAGAAGAACTTACGCTCGGCGTCCCACT
CCAAATGATGACACTTTGGATGAAGGAGTAGGACTTGTGCATTCAAACATAGCAACTGAGTGGTCTGCGCCCAGGGCTTGCAGGCAAAGG
ACAAGACAGGATCCAGTGACCCCTATGTCACCGTCCAGGTCGGGAAGACCAAGAAACGGACAAAAACCATCTATGGGAACCTCAACCCGG
TGTGGGAGGAGAATTTCCACTTTGAATGTCACAATTCCTCCGACCGCATCAAGGTGCGCGTCTGGGACGAGGATGACGACATCAAATCCC
GCGTGAAACAGAGGTTCAAGAGGGAATCTGACGATTTCCTGGGGCAGACGATCATTGAGGTGCGGACGCTCAGCGGCGAGATGGACGTGT
GGTACAACCTGGACAAGCGAACTGACAAATCTGCCGTGTCGGGTGCCATCCGGCTCCACATCAGTGTGGAGATCAAAGGCGAGGAGAAGG
TGGCCCCGTACCATGTCCAGTACACCTGTCTGCATGAGAACCTGTTCCACTTCGTGACCGACGTGCAGAACAATGGGGTCGTGAAGATCC
CAGATGCCAAGGGTGACGATGCCTGGAAGGTTTACTACGATGAGACAGCCCAGGAGATTGTGGACGAGTTTGCCATGCGCTACGGCGTCG
AGTCCATCTACCAAGCCATGACCCACTTTGCCTGCCTCTCCTCCAAGTATATGTGCCCAGGGGTGCCTGCCGTCATGAGCACCCTGCTCG
CCAACATCAATGCCTACTACGCACACACCACCGCCTCCACCAACGTGTCTGCCTCCGACCGCTTCGCCGCCTCCAACTTTGGGAAAGAGC
GCTTCGTGAAACTCCTGGACCAGCTGCATAACTCCCTGCGGATTGACCTCTCCATGTACCGGAATAACTTCCCAGCCAGCAGCCCGGAGA
GACTCCAGGACCTCAAATCCACTGTGGACCTTCTCACCAGCATCACCTTCTTTCGGATGAAGGTACAAGAACTCCAGAGCCCGCCCCGAG
CCAGCCAGGTGGTAAAGGACTGTGTGAAAGCCTGCCTTAATTCTACCTACGAGTACATCTTCAATAACTGCCATGAACTGTACAGCCGGG
AGTACCAGACAGACCCGGCCAAGAAGGGGGAAGTTCTCCCAGAGGAACAGGGGCCCAGCATCAAGAACCTCGACTTCTGGTCCAAGCTGA
TTACCCTCATAGTGTCCATCATTGAGGAAGACAAGAATTCCTACACTCCCTGCCTCAACCAGTTTCCCCAGGAGCTGAATGTGGGTAAAA
TCAGCGCTGAAGTGATGTGGAATCTGTTTGCCCAAGACATGAAGTACGCCATGGAGGAGCACGACAAGCATCGTCTATGCAAGAGTGCCG
ACTACATGAACCTCCACTTCAAGGTGAAATGGCTCTACAATGAGTATGTGACGGAACTTCCCGCCTTCAAGGACCGCGTGCCTGAGTACC
CTGCATGGTTTGAACCCTTCGTCATCCAGTGGCTGGATGAGAATGAGGAGGTGTCCCGGGATTTCCTGCACGGTGCCCTGGAGCGAGACA
AGAAGGATGGGTTCCAGCAGACCTCAGAGCATGCCCTATTCTCCTGCTCCGTGGTGGATGTTTTCTCCCAACTCAACCAGAGCTTTGAAA
TCATCAAGAAACTCGAGTGTCCCGACCCTCAGATCGTGGGGCACTACATGAGGCGCTTTGCCAAGACCATCAGTAATGTGCTCCTCCAGT
ATGCAGACATCATCTCCAAGGACTTTGCCTCCTACTGCTCCAAGGAGAAGGAGAAAGTGCCCTGCATTCTCATGAATAACACTCAACAGC
TACGAGTTCAGCTGGAGAAGATGTTCGAAGCCATGGGAGGAAAGGAGCTGGATGCTGAAGCCAGTGACATCCTGAAGGAGCTTCAGGTGA
AACTCAATAACGTCTTGGATGAGCTCAGCCGGGTGTTTGCTACCAGCTTCCAGCCGCACATTGAAGAGTGTGTCAAACAGATGGGTGACA
TCCTTAGCCAGGTTAAGGGCACAGGCAATGTGCCAGCCAGTGCCTGCAGCAGCGTGGCCCAGGACGCGGACAATGTGTTGCAGCCCATCA
TGGACCTGCTGGACAGCAACCTGACCCTCTTTGCCAAAATCTGTGAGAAGACTGTGCTGAAGCGAGTGCTGAAGGAGCTGTGGAAGCTGG
TTATGAACACCATGGAGAAAACCATCGTCCTGCCGCCCCTCACTGACCAGACGATGATCGGGAACCTCTTGAGAAAACATGGCAAGGGAT
TAGAAAAGGGCAGGGTGAAATTGCCAAGCCACTCAGACGGAACCCAGATGATCTTCAATGCAGCCAAGGAGCTGGGTCAGCTGTCCAAAC
TCAAGGATCACATGGTACGAGAAGAAGCCAAGAGCTTGACCCCAAAGCAGTGCGCGGTTGTTGAGTTGGCCCTGGACACCATCAAGCAAT
ATTTCCACGCGGGTGGCGTGGGCCTCAAGAAGACCTTCCTGGAGAAGAGCCCGGACCTGCAATCCTTGCGCTATGCCCTGTCGCTCTACA
CGCAGGCCACCGACCTGCTAATCAAGACCTTTGTACAGACGCAATCGGCCCAGGGCTTGGGTGTAGAAGACCCTGTGGGTGAAGTCTCTG
TCCATGTTGAGCTGTTCACTCATCCAGGAACTGGGGAACACAAGGTCACAGTGAAAGTGGTGGCTGCCAATGACCTCAAGTGGCAGACTT
CTGGCATCTTCCGGCCGTTCATCGAGGTCAACATCATTGGGCCCCAGCTCAGCGACAAGAAACGCAAGTTTGCGACCAAATCCAAGAACA
ATAGCTGGGCTCCCAAGTACAATGAGAGCTTCCAGTTCACGCTGAGCGCCGACGCGGGTCCCGAGTGCTATGAGCTGCAGGTGTGCGTCA
AGGACTACTGCTTCGCGCGCGAGGACCGCACGGTGGGGCTGGCCGTGCTGCAGCTGCGTGAGCTGGCCCAGCGCGGGAGCGCCGCCTGCT
GGCTGCCGCTCGGCCGCCGCATCCACATGGACGACACGGGCCTCACGGTGCTGCGAATCCTCTCGCAGCGCAGCAACGACGAGGTGGCCA
AGGAGTTCGTGAAGCTCAAGTCGGACACGCGCTCCGCCGAGGAGGGCGGTGCCGCGCCTGCGCCTTAGCGCGGGCGGTCGGCCGAGCGGC
ACTGCGCCTGCGCGGAGGGCGCTGGGCGGGGAGGGACGGGGCTTGCGCCTTGGTGGGACCTCCCCAGGGGCGGGGCTCGGGGGGCTCCAC
GCCAAGGGTGGGCTGCGCCTACGCCCTTGACTCAGCTTTCCCTTTTGGGGAATTAGGAATGGAGGATGCCCCGCCCTCTCGGGAGGCCAC
GCCCAAGGGCGCGACGAAGGAAGGAGCCACATCCCCAACTTGAGGCCACGCCCCCAGCACCTAGGGGGCATTTTGAGCTGGGATGGGGGA
AACCTCGTCCCTATGGAGGAGGCCACATCCCGGGGCTCTGGTACCGGGAGGCACCACCTCATGTCCCCTGGAAAAGCCATAAGATGGGAC
CCAGACCCCTGGGACCCCAGACCAATTGCCAAGTATGGAAATCTCAGCTCCCTCGAGGGGGGGCCCTGGGCAAGGGGTAGGGCTCTCTGG
AGCGCCCCTCTAGGTGGCCTGGGGACTGGAGGGACCAGGATGCTGGTTGGAGGGCCCCGGAATACCGGAGTCCCTTTAGATATTTGTGCA
AAAAATAAATGGGGGGAGGGGGGAGGATGGGATTTCAAAAGCACATGCGCCCTTGGGCGCCCAAACCCTGGGGGCCGAGGGGACGGCTCT
GGTTCCCCACGCTGCCCCTACTTCCCTTTGGGAGTTTGCCTCTCCCTCTCCCCCAACAAACCCAGTCCTCATATCATAGAGTTCAACACA
CCCATTTGACAGATGGCAAAACTGAGGCTTAAAGAGCTGCTTGAGACTTGGCCAAGGTTCCAGGTGCCATACCCTCTGTGCCCCTCCCTT
AGGCCTGTGTGCCCCATGGAAGGGTGGGCTGAGATCGGGATGACCTGACACAGCTCCCTATTGCTGCTAATTCCCCCTCGGCCTCCTCCA
AGGGGTGGGAATTCCAGGCCAAGACCCCTACTTCGCCTTTCCTTCTCCGGCTGCCAAGCAGGACCTTTGCCCTCAGCCCTTTCTCCTGGG
ATCTCCATGGGGGATGCCATGAGGGCCTCCCACCACAAAAGAGAATTTGGGATCCCCTGGTCCCAGGTTTCTCCATCCCTTCTTCCTTTT
CCAGAATTTTCCAAATAGGAAAGAACAGAAGGAGACCAGAAACTCTAGGGGGGAGAAAGAGAATGAGAGAAAGAGAATGAGAGAGAGAGA
AACACAAACACAGTGACACAGTGAGAGCTTAGTCTCCAAGAGCCTATTCATTGATTCAAACACCCAAGCCACAGGATACCTCAGATGGCC
CTCTTGCCAGCTGGAAGCTCTTTCTCCAATGAGCAAAGTTACAGTGACCTGGCTGGAGTTACCTGGTGCACATAGGACCTTAGGGGAAAG
TTCAGCGTGGACTACACTTGCTCTGGGATCTGCTTTTCCACATGTGTGTATGGCACGCCTTTTTCTGCTGGATTGGGAAGGACAAGATTT
TGCTGTGCTAGGGAGAAATGAAAACGGGGTGAGCTGAGTAGCTGGGTTTCTGGAGGATAGAACATCAGATGGGGAGGCTTTCCGAGGTGA
AGAATGAGAGGGAACCACTTACTAGAGAGAAAAGAGCTCCAGGCCTGGGGAACAGCACGTGCGAAGGCCAGGAGAGAAGAACTGTTGAAA
CAACGAGAAGGGTGGCACGGCTGGAGCTGAGCCAGCAAGGGGGATCGTGAGGAGCCTTGGGGTTGGGGAGATCTGCAGAAGCATCAGACC
AGGCAGGGCCTCGTACGCAGTCCTGAGGAGTTTTACTTTTATTCTAAGACAGTTGGGGAGCTCCAGGAGCTGTTTTAAGTTGGGGAGAGA
CTGGATTCCAGCCTGCAAAAGCTGTTTTGTGAAGACTAAAACCAGTGAGGAGAGGTGGAGGTGCTTTGGGGACACTGAAATGGATTCTTG
GAAAGATTCTGAAGGCTGTGTTGAAAAGACACCTATAGCTGTGGGGACATGACTATAATCCCAGCATTTGGGGAGACCGAGGCTGGCAGA
TCACTTAAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTGCTAAAAATACAAAAATTAGCTGGGTGCAGTGG
TGCATGCCTGTAGTCCCAGCTACTCAGGAGACTGAGGCGGGAGAATTGTTTGAACCCTGGAGGCAGAGGTTGTAGTGAGTCGTGATCACA
CAACTGCACTCCAGCCTGGGCAACAGAACAATACTCCATTCCCTCCCCTCTACCCCACCAAAAAAAAAAAAAAATCCTGCCCTTAGATGA
GCTCTAGGGCTGCTGAGTACAGTTGTCCCAGTTGCACAGTGCCCAAGGGTTTGGCATTGCTAAGAAGGCCACGTGCAAATCCTAGATATT
GAGTGTTGTATGTTTGTGACGTTGGTTTCCCGACATGTGAATGGCCCAAGTGTCTGGAAGAAGTGGCGCCACTTTCTAATTTGCTTGGAG
ATGTTGCATGTCCCTTAAATTCAGACAGGTGCAGGTAACTGGAGGTTCTGAACCAAAGGTTAAAATGCAAATTCTCATACAGGGTTGGGA
AGTTGTAGCCAGGGATAAGCTTATGTGACTGTTATATGGACTGAGGAGCAGATGTGAATTTCGAACCATGACATGGCTGAGGGTAGGGGT
CGGGTGGATGGATGATTCAGGGTTGTAACCCATAGAGCCCAAAGGGGAAGTGATCTGTGACCTGGGGTGAGGGTGATCTGGAAGATTTTT
GGATGGCTGGAAAGAAATGGGGAAGTCGAGCTGCCTGAGAGAGCCAAGTTATTTCCCAAAAGATTCCTTAGGAGTCTTTCTGTTCAAGAC
CTCCGTGTGTGTGTGTGTGTGTTTAGGGTTCCCCAGCAATGGCCCAGGCATGTGAAGGAAACAAGCTTCTTCAGGGAATATTTGTTGAAT
GAGTTTTCCTGACTCCCAGGCTAGAACTGTTTTTGCAATTTCCACCCTCTTTTCTTTCCCCCAGAGAACTCCTATTCGTCCTTCAAAACC
CATCACGGAAACCCCTCTTGGAGAAAACCCTCCTTCCTTCCCCTCAGGACTTTCCCAGCCACCGTCTCTCCTCCAGTCCAGCCTGATGCC
ATGGGACTGGGGGTTTCTCTGTCCAGCTCTGTTTCTCCCAGACTGGGGTCTGAGGACTCTCAGGACCCCCAACTTTACCTAGCACAGGCT
GGGCACAAGTGGGTGACAGGGAGTCTACGCCTAGTGGAATTATGTATTGGGGCAGGGTCAGTGTGAGAATACACATCCGCATGCATGTCT
GTCCATGTCTGTCCGTACCAACCTTCCCCTTCCACACGGACCTGGGCACATAGGAGGTGTCTGAGCCTGACACATGGGACAGAGAGTGGA
CATGGCTGAGACACGGACAGAGAAAAGACAAGGAGTCCAGGGGGCTGAAAGCCTTTTGAAATCAGGAAGTTCCTGTATTGGCAGAACAAA
GCCCAGAGAGGAGCAGGGCTTTCCTCAACGCCACCCAGCAAGTGGACACAGAGCCCGGCCTTGGATGACACCTCCAGGGTTCTGAACCCT
GGACCTCGCTTTATGCAAGGAGCTGGCCCCACATTTCCATGAATCGGGGAAACAGCACAAGAAGGTTGGCCTGTGGCAGGGCAAGGGTTA
AAGGGGTGACATTGAGGGATGCCTCAGAGTCAAAGTCCCCTGACCAAGAGGAATAGAGTAGAAAACACAGAGACAGAGGGTGAGATCACG
CCCCGATGAGGACGGAGAGAGACAGAGATGGAGAGAGACATAGAGGTGGAAATATACAGAGAAAGATAAATGCAGAGACCAAGGCAGGGA
GTGTCGGGGGAAGTAAAGAGGGTGTCCTGAAGAAAGAAGGATCTGTTCACTCTTACCAGTCTGTCCTCGAATGATTTGCATAAAATGAGG
AGGTGCCTGTCCACACCCCCAATTCCTCTCTCAGGCCCCAGAGCCTGAGACCTCACCATGCCCCCATCAGAGATGCAAAAAACTAAACAC
CCAACTAGAAATCCTTGGGACCTCTCTCGGCTGGGATCTCAGAGCCTTTCTGTCCCCTACCCCTACCCCATGTGCTGTCGATTTTGCAGA
TGGGGACAACCTGGGGCCTCCCGGAACTCTGCCACCCTGGGGAAGTTGGGGGAGGGCCTTAGTCCCGGATCACAACCCCGTCTGCTCCCC
AGAATCCTTTCCTAAGAATCGTTGAGGACCAAAGTTGTCTTTGCTGACACGTGTTGCTTTTCTCTTTGCCTTTTATTGTTTCAGAGAAAA
ATCAAGTTGACTGTGTCAAGTAACACCCCACCCCTTACCCCCGTCCAGCCATAGTGGCTCTCTGGAGACACAGGTCACAGGCGGAGGGTC
CCCTGATCATCCCCAACCACACAGCCAGGGGGACTTGACCCCTGTCCACCCCTGTCTCGTGCTCCCTCAGACCCCCACAAACCGGCCAAG
CAGTCCGGGGAGGCTTCCCCTCCACACAACTCTTAGCATGTGATTGCAGATGTGAAATCAAAACGTTGTTTGTTTTTTGTTTTGTTTTGA
TTCTACCCCGTCGGTCCAGTGTCTGCACAGACGCCTTCATTTCTCTGTAAATATGTGACTTGGAACAAATGTTTAACACAAACGAGAAGT
GGTCATGAATGCATGGTGTTGAGATGTTTTGCACTATTCTGACTTTTTGGTCTCTGTAAAAATATTTTATTAACAGCAGACATTAAAAAA

>36923_36923_2_HMGCS1-UNC13A_HMGCS1_chr5_43292576_ENST00000325110_UNC13A_chr19_17756920_ENST00000428389_length(amino acids)=1016AA_BP=
MQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSG
EMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAM
RYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPA
SSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDF
WSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDR
VPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISN
VLLQYADIISKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVK
QMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRK
HGKGLEKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYA
LSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSVHVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFAT
KSKNNSWAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSN

--------------------------------------------------------------
>36923_36923_3_HMGCS1-UNC13A_HMGCS1_chr5_43292576_ENST00000325110_UNC13A_chr19_17756920_ENST00000519716_length(transcript)=9474nt_BP=1680nt
GTCCCGCCTCCCAGCGACTCTCGGCGGTGCCGGAGTCGGGTGGGTTGGCGGCTATAAAGCTGGTGGCGAAGGGGAGGCGCCGCGGACTGT
CCTTTCGTGGCTCACTCCCTTTCCTCTGCTGCCGCTCGGTCACGCTTGTGCCCGAAGGAGGAAACAGTGACAGACCTGGAGACTGCAGTT
CTCTATCCTTCACACAGCTCTTTCACCATGCCTGGATCACTTCCTTTGAATGCAGAAGCTTGCTGGCCAAAAGATGTGGGAATTGTTGCC
CTTGAGATCTATTTTCCTTCTCAATATGTTGATCAAGCAGAGTTGGAAAAATATGATGGTGTAGATGCTGGAAAGTATACCATTGGCTTG
GGCCAGGCCAAGATGGGCTTCTGCACAGATAGAGAAGATATTAACTCTCTTTGCATGACTGTGGTTCAGAATCTTATGGAGAGAAATAAC
CTTTCCTATGATTGCATTGGGCGGCTGGAAGTTGGAACAGAGACAATCATCGACAAATCAAAGTCTGTGAAGACTAATTTGATGCAGCTG
TTTGAAGAGTCTGGGAATACAGATATAGAAGGAATCGACACAACTAATGCATGCTATGGAGGCACAGCTGCTGTCTTCAATGCTGTTAAC
TGGATTGAGTCCAGCTCTTGGGATGGACGGTATGCCCTGGTAGTTGCAGGAGATATTGCTGTATATGCCACAGGAAATGCTAGACCTACA
GGTGGAGTTGGAGCAGTAGCTCTGCTAATTGGGCCAAATGCTCCTTTAATTTTTGAACGAGGGCTTCGTGGGACACATATGCAACATGCC
TATGATTTTTACAAGCCTGATATGCTATCTGAATATCCTATAGTAGATGGAAAACTCTCCATACAGTGCTACCTCAGTGCATTAGACCGC
TGCTATTCTGTCTACTGCAAAAAGATCCATGCCCAGTGGCAGAAAGAGGGAAATGATAAAGATTTTACCTTGAATGATTTTGGCTTCATG
ATCTTTCACTCACCATATTGTAAACTGGTTCAGAAATCTCTAGCTCGGATGTTGCTGAATGACTTCCTTAATGACCAGAATAGAGATAAA
AATAGTATCTATAGTGGCCTGGAAGCCTTTGGGGATGTTAAATTAGAAGACACCTACTTTGATAGAGATGTGGAGAAGGCATTTATGAAG
GCTAGCTCTGAACTCTTCAGTCAGAAAACAAAGGCATCTTTACTTGTATCAAATCAAAATGGAAATATGTACACATCTTCAGTATATGGT
TCCCTTGCATCTGTTCTAGCACAGTACTCACCTCAGCAATTAGCAGGGAAGAGAATTGGAGTGTTTTCTTATGGTTCTGGTTTGGCTGCC
ACTCTGTACTCTCTTAAAGTCACACAAGATGCTACACCGGGGTCTGCTCTTGATAAAATAACAGCAAGTTTATGTGATCTTAAATCAAGG
CTTGATTCAAGAACTGGTGTGGCACCAGATGTCTTCGCTGAAAACATGAAGCTCAGAGAGGACACCCATCATTTGGTCAACTATATTCCC
CAGGGTTCAATAGATTCACTCTTTGAAGGAACGTGGTACTTAGTTAGGGTGGATGAAAAGCACAGAAGAACTTACGCTCGGCGTCCCACT
CCAAATGATGACACTTTGGATGAAGGAGTAGGACTTGTGCATTCAAACATAGCAACTGAGTGGTCTGCGCCCAGGGCTTGCAGGCAAAGG
ACAAGACAGGATCCAGTGACCCCTATGTCACCGTCCAGGTCGGGAAGACCAAGAAACGGACAAAAACCATCTATGGGAACCTCAACCCGG
TGTGGGAGGAGAATTTCCACTTTGAATGTCACAATTCCTCCGACCGCATCAAGGTGCGCGTCTGGGACGAGGATGACGACATCAAATCCC
GCGTGAAACAGAGGTTCAAGAGGGAATCTGACGATTTCCTGGGGCAGACGATCATTGAGGTGCGGACGCTCAGCGGCGAGATGGACGTGT
GGTACAACCTGGACAAGCGAACTGACAAATCTGCCGTGTCGGGTGCCATCCGGCTCCACATCAGTGTGGAGATCAAAGGCGAGGAGAAGG
TGGCCCCGTACCATGTCCAGTACACCTGTCTGCATGAGAACCTGTTCCACTTCGTGACCGACGTGCAGAACAATGGGGTCGTGAAGATCC
CAGATGCCAAGGGTGACGATGCCTGGAAGGTTTACTACGATGAGACAGCCCAGGAGATTGTGGACGAGTTTGCCATGCGCTACGGCGTCG
AGTCCATCTACCAAGCCATGACCCACTTTGCCTGCCTCTCCTCCAAGTATATGTGCCCAGGGGTGCCTGCCGTCATGAGCACCCTGCTCG
CCAACATCAATGCCTACTACGCACACACCACCGCCTCCACCAACGTGTCTGCCTCCGACCGCTTCGCCGCCTCCAACTTTGGGAAAGAGC
GCTTCGTGAAACTCCTGGACCAGCTGCATAACTCCCTGCGGATTGACCTCTCCATGTACCGGAATAACTTCCCAGCCAGCAGCCCGGAGA
GACTCCAGGACCTCAAATCCACTGTGGACCTTCTCACCAGCATCACCTTCTTTCGGATGAAGGTACAAGAACTCCAGAGCCCGCCCCGAG
CCAGCCAGGTGGTAAAGGACTGTGTGAAAGCCTGCCTTAATTCTACCTACGAGTACATCTTCAATAACTGCCATGAACTGTACAGCCGGG
AGTACCAGACAGACCCGGCCAAGAAGGGGGAAGTTCTCCCAGAGGAACAGGGGCCCAGCATCAAGAACCTCGACTTCTGGTCCAAGCTGA
TTACCCTCATAGTGTCCATCATTGAGGAAGACAAGAATTCCTACACTCCCTGCCTCAACCAGTTTCCCCAGGAGCTGAATGTGGGTAAAA
TCAGCGCTGAAGTGATGTGGAATCTGTTTGCCCAAGACATGAAGTACGCCATGGAGGAGCACGACAAGCATCGTCTATGCAAGAGTGCCG
ACTACATGAACCTCCACTTCAAGGTGAAATGGCTCTACAATGAGTATGTGACGGAACTTCCCGCCTTCAAGGACCGCGTGCCTGAGTACC
CTGCATGGTTTGAACCCTTCGTCATCCAGTGGCTGGATGAGAATGAGGAGGTGTCCCGGGATTTCCTGCACGGTGCCCTGGAGCGAGACA
AGAAGGATGGGTTCCAGCAGACCTCAGAGCATGCCCTATTCTCCTGCTCCGTGGTGGATGTTTTCTCCCAACTCAACCAGAGCTTTGAAA
TCATCAAGAAACTCGAGTGTCCCGACCCTCAGATCGTGGGGCACTACATGAGGCGCTTTGCCAAGACCATCAGTAATGTGCTCCTCCAGT
ATGCAGACATCATCTCCAAGGACTTTGCCTCCTACTGCTCCAAGGAGAAGGAGAAAGTGCCCTGCATTCTCATGAATAACACTCAACAGC
TACGAGTTCAGCTGGAGAAGATGTTCGAAGCCATGGGAGGAAAGGAGCTGGATGCTGAAGCCAGTGACATCCTGAAGGAGCTTCAGGTGA
AACTCAATAACGTCTTGGATGAGCTCAGCCGGGTGTTTGCTACCAGCTTCCAGCCGCACATTGAAGAGTGTGTCAAACAGATGGGTGACA
TCCTTAGCCAGGTTAAGGGCACAGGCAATGTGCCAGCCAGTGCCTGCAGCAGCGTGGCCCAGGACGCGGACAATGTGTTGCAGCCCATCA
TGGACCTGCTGGACAGCAACCTGACCCTCTTTGCCAAAATCTGTGAGAAGACTGTGCTGAAGCGAGTGCTGAAGGAGCTGTGGAAGCTGG
TTATGAACACCATGGAGAAAACCATCGTCCTGCCGCCCCTCACTGACCAGACGATGATCGGGAACCTCTTGAGAAAACATGGCAAGGGAT
TAGAAAAGGGCAGGGTGAAATTGCCAAGCCACTCAGACGGAACCCAGATGATCTTCAATGCAGCCAAGGAGCTGGGTCAGCTGTCCAAAC
TCAAGGATCACATGGTACGAGAAGAAGCCAAGAGCTTGACCCCAAAGCAGTGCGCGGTTGTTGAGTTGGCCCTGGACACCATCAAGCAAT
ATTTCCACGCGGGTGGCGTGGGCCTCAAGAAGACCTTCCTGGAGAAGAGCCCGGACCTGCAATCCTTGCGCTATGCCCTGTCGCTCTACA
CGCAGGCCACCGACCTGCTAATCAAGACCTTTGTACAGACGCAATCGGCCCAGGGCTTGGGTGTAGAAGACCCTGTGGGTGAAGTCTCTG
TCCATGTTGAGCTGTTCACTCATCCAGGAACTGGGGAACACAAGGTCACAGTGAAAGTGGTGGCTGCCAATGACCTCAAGTGGCAGACTT
CTGGCATCTTCCGGCCGTTCATCGAGGTCAACATCATTGGGCCCCAGCTCAGCGACAAGAAACGCAAGTTTGCGACCAAATCCAAGAACA
ATAGCTGGGCTCCCAAGTACAATGAGAGCTTCCAGTTCACGCTGAGCGCCGACGCGGGTCCCGAGTGCTATGAGCTGCAGGTGTGCGTCA
AGGACTACTGCTTCGCGCGCGAGGACCGCACGGTGGGGCTGGCCGTGCTGCAGCTGCGTGAGCTGGCCCAGCGCGGGAGCGCCGCCTGCT
GGCTGCCGCTCGGCCGCCGCATCCACATGGACGACACGGGCCTCACGGTGCTGCGAATCCTCTCGCAGCGCAGCAACGACGAGGTGGCCA
AGGAGTTCGTGAAGCTCAAGTCGGACACGCGCTCCGCCGAGGAGGGCGGTGCCGCGCCTGCGCCTTAGCGCGGGCGGTCGGCCGAGCGGC
ACTGCGCCTGCGCGGAGGGCGCTGGGCGGGGAGGGACGGGGCTTGCGCCTTGGTGGGACCTCCCCAGGGGCGGGGCTCGGGGGGCTCCAC
GCCAAGGGTGGGCTGCGCCTACGCCCTTGACTCAGCTTTCCCTTTTGGGGAATTAGGAATGGAGGATGCCCCGCCCTCTCGGGAGGCCAC
GCCCAAGGGCGCGACGAAGGAAGGAGCCACATCCCCAACTTGAGGCCACGCCCCCAGCACCTAGGGGGCATTTTGAGCTGGGATGGGGGA
AACCTCGTCCCTATGGAGGAGGCCACATCCCGGGGCTCTGGTACCGGGAGGCACCACCTCATGTCCCCTGGAAAAGCCATAAGATGGGAC
CCAGACCCCTGGGACCCCAGACCAATTGCCAAGTATGGAAATCTCAGCTCCCTCGAGGGGGGGCCCTGGGCAAGGGGTAGGGCTCTCTGG
AGCGCCCCTCTAGGTGGCCTGGGGACTGGAGGGACCAGGATGCTGGTTGGAGGGCCCCGGAATACCGGAGTCCCTTTAGATATTTGTGCA
AAAAATAAATGGGGGGAGGGGGGAGGATGGGATTTCAAAAGCACATGCGCCCTTGGGCGCCCAAACCCTGGGGGCCGAGGGGACGGCTCT
GGTTCCCCACGCTGCCCCTACTTCCCTTTGGGAGTTTGCCTCTCCCTCTCCCCCAACAAACCCAGTCCTCATATCATAGAGTTCAACACA
CCCATTTGACAGATGGCAAAACTGAGGCTTAAAGAGCTGCTTGAGACTTGGCCAAGGTTCCAGGTGCCATACCCTCTGTGCCCCTCCCTT
AGGCCTGTGTGCCCCATGGAAGGGTGGGCTGAGATCGGGATGACCTGACACAGCTCCCTATTGCTGCTAATTCCCCCTCGGCCTCCTCCA
AGGGGTGGGAATTCCAGGCCAAGACCCCTACTTCGCCTTTCCTTCTCCGGCTGCCAAGCAGGACCTTTGCCCTCAGCCCTTTCTCCTGGG
ATCTCCATGGGGGATGCCATGAGGGCCTCCCACCACAAAAGAGAATTTGGGATCCCCTGGTCCCAGGTTTCTCCATCCCTTCTTCCTTTT
CCAGAATTTTCCAAATAGGAAAGAACAGAAGGAGACCAGAAACTCTAGGGGGGAGAAAGAGAATGAGAGAAAGAGAATGAGAGAGAGAGA
AACACAAACACAGTGACACAGTGAGAGCTTAGTCTCCAAGAGCCTATTCATTGATTCAAACACCCAAGCCACAGGATACCTCAGATGGCC
CTCTTGCCAGCTGGAAGCTCTTTCTCCAATGAGCAAAGTTACAGTGACCTGGCTGGAGTTACCTGGTGCACATAGGACCTTAGGGGAAAG
TTCAGCGTGGACTACACTTGCTCTGGGATCTGCTTTTCCACATGTGTGTATGGCACGCCTTTTTCTGCTGGATTGGGAAGGACAAGATTT
TGCTGTGCTAGGGAGAAATGAAAACGGGGTGAGCTGAGTAGCTGGGTTTCTGGAGGATAGAACATCAGATGGGGAGGCTTTCCGAGGTGA
AGAATGAGAGGGAACCACTTACTAGAGAGAAAAGAGCTCCAGGCCTGGGGAACAGCACGTGCGAAGGCCAGGAGAGAAGAACTGTTGAAA
CAACGAGAAGGGTGGCACGGCTGGAGCTGAGCCAGCAAGGGGGATCGTGAGGAGCCTTGGGGTTGGGGAGATCTGCAGAAGCATCAGACC
AGGCAGGGCCTCGTACGCAGTCCTGAGGAGTTTTACTTTTATTCTAAGACAGTTGGGGAGCTCCAGGAGCTGTTTTAAGTTGGGGAGAGA
CTGGATTCCAGCCTGCAAAAGCTGTTTTGTGAAGACTAAAACCAGTGAGGAGAGGTGGAGGTGCTTTGGGGACACTGAAATGGATTCTTG
GAAAGATTCTGAAGGCTGTGTTGAAAAGACACCTATAGCTGTGGGGACATGACTATAATCCCAGCATTTGGGGAGACCGAGGCTGGCAGA
TCACTTAAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCGAAACCCCATCTCTGCTAAAAATACAAAAATTAGCTGGGTGCAGTGG
TGCATGCCTGTAGTCCCAGCTACTCAGGAGACTGAGGCGGGAGAATTGTTTGAACCCTGGAGGCAGAGGTTGTAGTGAGTCGTGATCACA
CAACTGCACTCCAGCCTGGGCAACAGAACAATACTCCATTCCCTCCCCTCTACCCCACCAAAAAAAAAAAAAAATCCTGCCCTTAGATGA
GCTCTAGGGCTGCTGAGTACAGTTGTCCCAGTTGCACAGTGCCCAAGGGTTTGGCATTGCTAAGAAGGCCACGTGCAAATCCTAGATATT
GAGTGTTGTATGTTTGTGACGTTGGTTTCCCGACATGTGAATGGCCCAAGTGTCTGGAAGAAGTGGCGCCACTTTCTAATTTGCTTGGAG
ATGTTGCATGTCCCTTAAATTCAGACAGGTGCAGGTAACTGGAGGTTCTGAACCAAAGGTTAAAATGCAAATTCTCATACAGGGTTGGGA
AGTTGTAGCCAGGGATAAGCTTATGTGACTGTTATATGGACTGAGGAGCAGATGTGAATTTCGAACCATGACATGGCTGAGGGTAGGGGT
CGGGTGGATGGATGATTCAGGGTTGTAACCCATAGAGCCCAAAGGGGAAGTGATCTGTGACCTGGGGTGAGGGTGATCTGGAAGATTTTT
GGATGGCTGGAAAGAAATGGGGAAGTCGAGCTGCCTGAGAGAGCCAAGTTATTTCCCAAAAGATTCCTTAGGAGTCTTTCTGTTCAAGAC
CTCCGTGTGTGTGTGTGTGTGTTTAGGGTTCCCCAGCAATGGCCCAGGCATGTGAAGGAAACAAGCTTCTTCAGGGAATATTTGTTGAAT
GAGTTTTCCTGACTCCCAGGCTAGAACTGTTTTTGCAATTTCCACCCTCTTTTCTTTCCCCCAGAGAACTCCTATTCGTCCTTCAAAACC
CATCACGGAAACCCCTCTTGGAGAAAACCCTCCTTCCTTCCCCTCAGGACTTTCCCAGCCACCGTCTCTCCTCCAGTCCAGCCTGATGCC
ATGGGACTGGGGGTTTCTCTGTCCAGCTCTGTTTCTCCCAGACTGGGGTCTGAGGACTCTCAGGACCCCCAACTTTACCTAGCACAGGCT
GGGCACAAGTGGGTGACAGGGAGTCTACGCCTAGTGGAATTATGTATTGGGGCAGGGTCAGTGTGAGAATACACATCCGCATGCATGTCT
GTCCATGTCTGTCCGTACCAACCTTCCCCTTCCACACGGACCTGGGCACATAGGAGGTGTCTGAGCCTGACACATGGGACAGAGAGTGGA
CATGGCTGAGACACGGACAGAGAAAAGACAAGGAGTCCAGGGGGCTGAAAGCCTTTTGAAATCAGGAAGTTCCTGTATTGGCAGAACAAA
GCCCAGAGAGGAGCAGGGCTTTCCTCAACGCCACCCAGCAAGTGGACACAGAGCCCGGCCTTGGATGACACCTCCAGGGTTCTGAACCCT
GGACCTCGCTTTATGCAAGGAGCTGGCCCCACATTTCCATGAATCGGGGAAACAGCACAAGAAGGTTGGCCTGTGGCAGGGCAAGGGTTA
AAGGGGTGACATTGAGGGATGCCTCAGAGTCAAAGTCCCCTGACCAAGAGGAATAGAGTAGAAAACACAGAGACAGAGGGTGAGATCACG
CCCCGATGAGGACGGAGAGAGACAGAGATGGAGAGAGACATAGAGGTGGAAATATACAGAGAAAGATAAATGCAGAGACCAAGGCAGGGA
GTGTCGGGGGAAGTAAAGAGGGTGTCCTGAAGAAAGAAGGATCTGTTCACTCTTACCAGTCTGTCCTCGAATGATTTGCATAAAATGAGG
AGGTGCCTGTCCACACCCCCAATTCCTCTCTCAGGCCCCAGAGCCTGAGACCTCACCATGCCCCCATCAGAGATGCAAAAAACTAAACAC
CCAACTAGAAATCCTTGGGACCTCTCTCGGCTGGGATCTCAGAGCCTTTCTGTCCCCTACCCCTACCCCATGTGCTGTCGATTTTGCAGA
TGGGGACAACCTGGGGCCTCCCGGAACTCTGCCACCCTGGGGAAGTTGGGGGAGGGCCTTAGTCCCGGATCACAACCCCGTCTGCTCCCC
AGAATCCTTTCCTAAGAATCGTTGAGGACCAAAGTTGTCTTTGCTGACACGTGTTGCTTTTCTCTTTGCCTTTTATTGTTTCAGAGAAAA
ATCAAGTTGACTGTGTCAAGTAACACCCCACCCCTTACCCCCGTCCAGCCATAGTGGCTCTCTGGAGACACAGGTCACAGGCGGAGGGTC
CCCTGATCATCCCCAACCACACAGCCAGGGGGACTTGACCCCTGTCCACCCCTGTCTCGTGCTCCCTCAGACCCCCACAAACCGGCCAAG
CAGTCCGGGGAGGCTTCCCCTCCACACAACTCTTAGCATGTGATTGCAGATGTGAAATCAAAACGTTGTTTGTTTTTTGTTTTGTTTTGA
TTCTACCCCGTCGGTCCAGTGTCTGCACAGACGCCTTCATTTCTCTGTAAATATGTGACTTGGAACAAATGTTTAACACAAACGAGAAGT
GGTCATGAATGCATGGTGTTGAGATGTTTTGCACTATTCTGACTTTTTGGTCTCTGTAAAAATATTTTATTAACAGCAGACATTAAAAAA

>36923_36923_3_HMGCS1-UNC13A_HMGCS1_chr5_43292576_ENST00000325110_UNC13A_chr19_17756920_ENST00000519716_length(amino acids)=1016AA_BP=
MQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSG
EMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAM
RYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPA
SSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDF
WSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDR
VPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISN
VLLQYADIISKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVK
QMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRK
HGKGLEKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYA
LSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSVHVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFAT
KSKNNSWAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSN

--------------------------------------------------------------
>36923_36923_4_HMGCS1-UNC13A_HMGCS1_chr5_43292576_ENST00000325110_UNC13A_chr19_17756920_ENST00000550896_length(transcript)=4676nt_BP=1680nt
GTCCCGCCTCCCAGCGACTCTCGGCGGTGCCGGAGTCGGGTGGGTTGGCGGCTATAAAGCTGGTGGCGAAGGGGAGGCGCCGCGGACTGT
CCTTTCGTGGCTCACTCCCTTTCCTCTGCTGCCGCTCGGTCACGCTTGTGCCCGAAGGAGGAAACAGTGACAGACCTGGAGACTGCAGTT
CTCTATCCTTCACACAGCTCTTTCACCATGCCTGGATCACTTCCTTTGAATGCAGAAGCTTGCTGGCCAAAAGATGTGGGAATTGTTGCC
CTTGAGATCTATTTTCCTTCTCAATATGTTGATCAAGCAGAGTTGGAAAAATATGATGGTGTAGATGCTGGAAAGTATACCATTGGCTTG
GGCCAGGCCAAGATGGGCTTCTGCACAGATAGAGAAGATATTAACTCTCTTTGCATGACTGTGGTTCAGAATCTTATGGAGAGAAATAAC
CTTTCCTATGATTGCATTGGGCGGCTGGAAGTTGGAACAGAGACAATCATCGACAAATCAAAGTCTGTGAAGACTAATTTGATGCAGCTG
TTTGAAGAGTCTGGGAATACAGATATAGAAGGAATCGACACAACTAATGCATGCTATGGAGGCACAGCTGCTGTCTTCAATGCTGTTAAC
TGGATTGAGTCCAGCTCTTGGGATGGACGGTATGCCCTGGTAGTTGCAGGAGATATTGCTGTATATGCCACAGGAAATGCTAGACCTACA
GGTGGAGTTGGAGCAGTAGCTCTGCTAATTGGGCCAAATGCTCCTTTAATTTTTGAACGAGGGCTTCGTGGGACACATATGCAACATGCC
TATGATTTTTACAAGCCTGATATGCTATCTGAATATCCTATAGTAGATGGAAAACTCTCCATACAGTGCTACCTCAGTGCATTAGACCGC
TGCTATTCTGTCTACTGCAAAAAGATCCATGCCCAGTGGCAGAAAGAGGGAAATGATAAAGATTTTACCTTGAATGATTTTGGCTTCATG
ATCTTTCACTCACCATATTGTAAACTGGTTCAGAAATCTCTAGCTCGGATGTTGCTGAATGACTTCCTTAATGACCAGAATAGAGATAAA
AATAGTATCTATAGTGGCCTGGAAGCCTTTGGGGATGTTAAATTAGAAGACACCTACTTTGATAGAGATGTGGAGAAGGCATTTATGAAG
GCTAGCTCTGAACTCTTCAGTCAGAAAACAAAGGCATCTTTACTTGTATCAAATCAAAATGGAAATATGTACACATCTTCAGTATATGGT
TCCCTTGCATCTGTTCTAGCACAGTACTCACCTCAGCAATTAGCAGGGAAGAGAATTGGAGTGTTTTCTTATGGTTCTGGTTTGGCTGCC
ACTCTGTACTCTCTTAAAGTCACACAAGATGCTACACCGGGGTCTGCTCTTGATAAAATAACAGCAAGTTTATGTGATCTTAAATCAAGG
CTTGATTCAAGAACTGGTGTGGCACCAGATGTCTTCGCTGAAAACATGAAGCTCAGAGAGGACACCCATCATTTGGTCAACTATATTCCC
CAGGGTTCAATAGATTCACTCTTTGAAGGAACGTGGTACTTAGTTAGGGTGGATGAAAAGCACAGAAGAACTTACGCTCGGCGTCCCACT
CCAAATGATGACACTTTGGATGAAGGAGTAGGACTTGTGCATTCAAACATAGCAACTGAGTGGTCTGCGCCCAGGGCTTGCAGGCAAAGG
ACAAGACAGGATCCAGTGACCCCTATGTCACCGTCCAGGTCGGGAAGACCAAGAAACGGACAAAAACCATCTATGGGAACCTCAACCCGG
TGTGGGAGGAGAATTTCCACTTTGAATGTCACAATTCCTCCGACCGCATCAAGGTGCGCGTCTGGGACGAGGATGACGACATCAAATCCC
GCGTGAAACAGAGGTTCAAGAGGGAATCTGACGATTTCCTGGGGCAGACGATCATTGAGGTGCGGACGCTCAGCGGCGAGATGGACGTGT
GGTACAACCTGGACAAGCGAACTGACAAATCTGCCGTGTCGGGTGCCATCCGGCTCCACATCAGTGTGGAGATCAAAGGCGAGGAGAAGG
TGGCCCCGTACCATGTCCAGTACACCTGTCTGCATGAGAACCTGTTCCACTTCGTGACCGACGTGCAGAACAATGGGGTCGTGAAGATCC
CAGATGCCAAGGGTGACGATGCCTGGAAGGTTTACTACGATGAGACAGCCCAGGAGATTGTGGACGAGTTTGCCATGCGCTACGGCGTCG
AGTCCATCTACCAAGCCATGACCCACTTTGCCTGCCTCTCCTCCAAGTATATGTGCCCAGGGGTGCCTGCCGTCATGAGCACCCTGCTCG
CCAACATCAATGCCTACTACGCACACACCACCGCCTCCACCAACGTGTCTGCCTCCGACCGCTTCGCCGCCTCCAACTTTGGGAAAGAGC
GCTTCGTGAAACTCCTGGACCAGCTGCATAACTCCCTGCGGATTGACCTCTCCATGTACCGGAATAACTTCCCAGCCAGCAGCCCGGAGA
GACTCCAGGACCTCAAATCCACTGTGGACCTTCTCACCAGCATCACCTTCTTTCGGATGAAGGTACAAGAACTCCAGAGCCCGCCCCGAG
CCAGCCAGGTGGTAAAGGACTGTGTGAAAGCCTGCCTTAATTCTACCTACGAGTACATCTTCAATAACTGCCATGAACTGTACAGCCGGG
AGTACCAGACAGACCCGGCCAAGAAGGGGGAAGTTCTCCCAGAGGAACAGGGGCCCAGCATCAAGAACCTCGACTTCTGGTCCAAGCTGA
TTACCCTCATAGTGTCCATCATTGAGGAAGACAAGAATTCCTACACTCCCTGCCTCAACCAGTTTCCCCAGGAGCTGAATGTGGGTAAAA
TCAGCGCTGAAGTGATGTGGAATCTGTTTGCCCAAGACATGAAGTACGCCATGGAGGAGCACGACAAGCATCGTCTATGCAAGAGTGCCG
ACTACATGAACCTCCACTTCAAGGTGAAATGGCTCTACAATGAGTATGTGACGGAACTTCCCGCCTTCAAGGACCGCGTGCCTGAGTACC
CTGCATGGTTTGAACCCTTCGTCATCCAGTGGCTGGATGAGAATGAGGAGGTGTCCCGGGATTTCCTGCACGGTGCCCTGGAGCGAGACA
AGAAGGATGGGTTCCAGCAGACCTCAGAGCATGCCCTATTCTCCTGCTCCGTGGTGGATGTTTTCTCCCAACTCAACCAGAGCTTTGAAA
TCATCAAGAAACTCGAGTGTCCCGACCCTCAGATCGTGGGGCACTACATGAGGCGCTTTGCCAAGACCATCAGTAATGTGCTCCTCCAGT
ATGCAGACATCATCTCCAAGGACTTTGCCTCCTACTGCTCCAAGGAGAAGGAGAAAGTGCCCTGCATTCTCATGAATAACACTCAACAGC
TACGAGTTCAGCTGGAGAAGATGTTCGAAGCCATGGGAGGAAAGGAGCTGGATGCTGAAGCCAGTGACATCCTGAAGGAGCTTCAGGTGA
AACTCAATAACGTCTTGGATGAGCTCAGCCGGGTGTTTGCTACCAGCTTCCAGCCGCACATTGAAGAGTGTGTCAAACAGATGGGTGACA
TCCTTAGCCAGGTTAAGGGCACAGGCAATGTGCCAGCCAGTGCCTGCAGCAGCGTGGCCCAGGACGCGGACAATGTGTTGCAGCCCATCA
TGGACCTGCTGGACAGCAACCTGACCCTCTTTGCCAAAATCTGTGAGAAGACTGTGCTGAAGCGAGTGCTGAAGGAGCTGTGGAAGCTGG
TTATGAACACCATGGAGAAAACCATCGTCCTGCCGCCCCTCACTGACCAGACGGGAACCCAGATGATCTTCAATGCAGCCAAGGAGCTGG
GTCAGCTGTCCAAACTCAAGGATCACATGGTACGAGAAGAAGCCAAGAGCTTGACCCCAAAGCAGTGCGCGGTTGTTGAGTTGGCCCTGG
ACACCATCAAGCAATATTTCCACGCGGGTGGCGTGGGCCTCAAGAAGACCTTCCTGGAGAAGAGCCCGGACCTGCAATCCTTGCGCTATG
CCCTGTCGCTCTACACGCAGGCCACCGACCTGCTAATCAAGACCTTTGTACAGACGCAATCGGCCCAGGGCTTGGGTGTAGAAGACCCTG
TGGGTGAAGTCTCTGTCCATGTTGAGCTGTTCACTCATCCAGGAACTGGGGAACACAAGGTCACAGTGAAAGTGGTGGCTGCCAATGACC
TCAAGTGGCAGACTTCTGGCATCTTCCGGCCGTTCATCGAGGTCAACATCATTGGGCCCCAGCTCAGCGACAAGAAACGCAAGTTTGCGA
CCAAATCCAAGAACAATAGCTGGGCTCCCAAGTACAATGAGAGCTTCCAGTTCACGCTGAGCGCCGACGCGGGTCCCGAGTGCTATGAGC
TGCAGGTGTGCGTCAAGGACTACTGCTTCGCGCGCGAGGACCGCACGGTGGGGCTGGCCGTGCTGCAGCTGCGTGAGCTGGCCCAGCGCG
GGAGCGCCGCCTGCTGGCTGCCGCTCGGCCGCCGCATCCACATGGACGACACGGGCCTCACGGTGCTGCGAATCCTCTCGCAGCGCAGCA

>36923_36923_4_HMGCS1-UNC13A_HMGCS1_chr5_43292576_ENST00000325110_UNC13A_chr19_17756920_ENST00000550896_length(amino acids)=991AA_BP=
MQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSG
EMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAM
RYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPA
SSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDF
WSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDR
VPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISN
VLLQYADIISKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVK
QMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTGTQMIFNA
AKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGLG
VEDPVGEVSVHVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNSWAPKYNESFQFTLSADAGP
ECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEEGGAAPA

--------------------------------------------------------------
>36923_36923_5_HMGCS1-UNC13A_HMGCS1_chr5_43292576_ENST00000325110_UNC13A_chr19_17756920_ENST00000551649_length(transcript)=5538nt_BP=1680nt
GTCCCGCCTCCCAGCGACTCTCGGCGGTGCCGGAGTCGGGTGGGTTGGCGGCTATAAAGCTGGTGGCGAAGGGGAGGCGCCGCGGACTGT
CCTTTCGTGGCTCACTCCCTTTCCTCTGCTGCCGCTCGGTCACGCTTGTGCCCGAAGGAGGAAACAGTGACAGACCTGGAGACTGCAGTT
CTCTATCCTTCACACAGCTCTTTCACCATGCCTGGATCACTTCCTTTGAATGCAGAAGCTTGCTGGCCAAAAGATGTGGGAATTGTTGCC
CTTGAGATCTATTTTCCTTCTCAATATGTTGATCAAGCAGAGTTGGAAAAATATGATGGTGTAGATGCTGGAAAGTATACCATTGGCTTG
GGCCAGGCCAAGATGGGCTTCTGCACAGATAGAGAAGATATTAACTCTCTTTGCATGACTGTGGTTCAGAATCTTATGGAGAGAAATAAC
CTTTCCTATGATTGCATTGGGCGGCTGGAAGTTGGAACAGAGACAATCATCGACAAATCAAAGTCTGTGAAGACTAATTTGATGCAGCTG
TTTGAAGAGTCTGGGAATACAGATATAGAAGGAATCGACACAACTAATGCATGCTATGGAGGCACAGCTGCTGTCTTCAATGCTGTTAAC
TGGATTGAGTCCAGCTCTTGGGATGGACGGTATGCCCTGGTAGTTGCAGGAGATATTGCTGTATATGCCACAGGAAATGCTAGACCTACA
GGTGGAGTTGGAGCAGTAGCTCTGCTAATTGGGCCAAATGCTCCTTTAATTTTTGAACGAGGGCTTCGTGGGACACATATGCAACATGCC
TATGATTTTTACAAGCCTGATATGCTATCTGAATATCCTATAGTAGATGGAAAACTCTCCATACAGTGCTACCTCAGTGCATTAGACCGC
TGCTATTCTGTCTACTGCAAAAAGATCCATGCCCAGTGGCAGAAAGAGGGAAATGATAAAGATTTTACCTTGAATGATTTTGGCTTCATG
ATCTTTCACTCACCATATTGTAAACTGGTTCAGAAATCTCTAGCTCGGATGTTGCTGAATGACTTCCTTAATGACCAGAATAGAGATAAA
AATAGTATCTATAGTGGCCTGGAAGCCTTTGGGGATGTTAAATTAGAAGACACCTACTTTGATAGAGATGTGGAGAAGGCATTTATGAAG
GCTAGCTCTGAACTCTTCAGTCAGAAAACAAAGGCATCTTTACTTGTATCAAATCAAAATGGAAATATGTACACATCTTCAGTATATGGT
TCCCTTGCATCTGTTCTAGCACAGTACTCACCTCAGCAATTAGCAGGGAAGAGAATTGGAGTGTTTTCTTATGGTTCTGGTTTGGCTGCC
ACTCTGTACTCTCTTAAAGTCACACAAGATGCTACACCGGGGTCTGCTCTTGATAAAATAACAGCAAGTTTATGTGATCTTAAATCAAGG
CTTGATTCAAGAACTGGTGTGGCACCAGATGTCTTCGCTGAAAACATGAAGCTCAGAGAGGACACCCATCATTTGGTCAACTATATTCCC
CAGGGTTCAATAGATTCACTCTTTGAAGGAACGTGGTACTTAGTTAGGGTGGATGAAAAGCACAGAAGAACTTACGCTCGGCGTCCCACT
CCAAATGATGACACTTTGGATGAAGGAGTAGGACTTGTGCATTCAAACATAGCAACTGAGTGGTCTGCGCCCAGGGCTTGCAGGCAAAGG
ACAAGACAGGATCCAGTGACCCCTATGTCACCGTCCAGGTCGGGAAGACCAAGAAACGGACAAAAACCATCTATGGGAACCTCAACCCGG
TGTGGGAGGAGAATTTCCACTTTGAATGTCACAATTCCTCCGACCGCATCAAGGTGCGCGTCTGGGACGAGGATGACGACATCAAATCCC
GCGTGAAACAGAGGTTCAAGAGGGAATCTGACGATTTCCTGGGGCAGACGATCATTGAGGTGCGGACGCTCAGCGGCGAGATGGACGTGT
GGTACAACCTGGACAAGCGAACTGACAAATCTGCCGTGTCGGGTGCCATCCGGCTCCACATCAGTGTGGAGATCAAAGGCGAGGAGAAGG
TGGCCCCGTACCATGTCCAGTACACCTGTCTGCATGAGAACCTGTTCCACTTCGTGACCGACGTGCAGAACAATGGGGTCGTGAAGATCC
CAGATGCCAAGGGTGACGATGCCTGGAAGGTTTACTACGATGAGACAGCCCAGGAGATTGTGGACGAGTTTGCCATGCGCTACGGCGTCG
AGTCCATCTACCAAGCCATGACCCACTTTGCCTGCCTCTCCTCCAAGTATATGTGCCCAGGGGTGCCTGCCGTCATGAGCACCCTGCTCG
CCAACATCAATGCCTACTACGCACACACCACCGCCTCCACCAACGTGTCTGCCTCCGACCGCTTCGCCGCCTCCAACTTTGGGAAAGAGC
GCTTCGTGAAACTCCTGGACCAGCTGCATAACTCCCTGCGGATTGACCTCTCCATGTACCGGAATAACTTCCCAGCCAGCAGCCCGGAGA
GACTCCAGGACCTCAAATCCACTGTGGACCTTCTCACCAGCATCACCTTCTTTCGGATGAAGGTACAAGAACTCCAGAGCCCGCCCCGAG
CCAGCCAGGTGGTAAAGGACTGTGTGAAAGCCTGCCTTAATTCTACCTACGAGTACATCTTCAATAACTGCCATGAACTGTACAGCCGGG
AGTACCAGACAGACCCGGCCAAGAAGGGGGAAGTTCTCCCAGAGGAACAGGGGCCCAGCATCAAGAACCTCGACTTCTGGTCCAAGCTGA
TTACCCTCATAGTGTCCATCATTGAGGAAGACAAGAATTCCTACACTCCCTGCCTCAACCAGTTTCCCCAGGAGCTGAATGTGGGTAAAA
TCAGCGCTGAAGTGATGTGGAATCTGTTTGCCCAAGACATGAAGTACGCCATGGAGGAGCACGACAAGCATCGTCTATGCAAGAGTGCCG
ACTACATGAACCTCCACTTCAAGGTGAAATGGCTCTACAATGAGTATGTGACGGAACTTCCCGCCTTCAAGGACCGCGTGCCTGAGTACC
CTGCATGGTTTGAACCCTTCGTCATCCAGTGGCTGGATGAGAATGAGGAGGTGTCCCGGGATTTCCTGCACGGTGCCCTGGAGCGAGACA
AGAAGGATGGGTTCCAGCAGACCTCAGAGCATGCCCTATTCTCCTGCTCCGTGGTGGATGTTTTCTCCCAACTCAACCAGAGCTTTGAAA
TCATCAAGAAACTCGAGTGTCCCGACCCTCAGATCGTGGGGCACTACATGAGGCGCTTTGCCAAGACCATCAGTAATGTGCTCCTCCAGT
ATGCAGACATCATCTCCAAGGACTTTGCCTCCTACTGCTCCAAGGAGAAGGAGAAAGTGCCCTGCATTCTCATGAATAACACTCAACAGC
TACGAGTTCAGCTGGAGAAGATGTTCGAAGCCATGGGAGGAAAGGAGCTGGATGCTGAAGCCAGTGACATCCTGAAGGAGCTTCAGGTGA
AACTCAATAACGTCTTGGATGAGCTCAGCCGGGTGTTTGCTACCAGCTTCCAGCCGCACATTGAAGAGTGTGTCAAACAGATGGGTGACA
TCCTTAGCCAGGTTAAGGGCACAGGCAATGTGCCAGCCAGTGCCTGCAGCAGCGTGGCCCAGGACGCGGACAATGTGTTGCAGCCCATCA
TGGACCTGCTGGACAGCAACCTGACCCTCTTTGCCAAAATCTGTGAGAAGACTGTGCTGAAGCGAGTGCTGAAGGAGCTGTGGAAGCTGG
TTATGAACACCATGGAGAAAACCATCGTCCTGCCGCCCCTCACTGACCAGACGATGATCGGGAACCTCTTGAGAAAACATGGCAAGGGAT
TAGAAAAGGGCAGGGTGAAATTGCCAAGCCACTCAGACGGAACCCAGATGATCTTCAATGCAGCCAAGGAGCTGGGTCAGCTGTCCAAAC
TCAAGGATCACATGGTACGAGAAGAAGCCAAGAGCTTGACCCCAAAGCAGTGCGCGGTTGTTGAGTTGGCCCTGGACACCATCAAGCAAT
ATTTCCACGCGGGTGGCGTGGGCCTCAAGAAGACCTTCCTGGAGAAGAGCCCGGACCTGCAATCCTTGCGCTATGCCCTGTCGCTCTACA
CGCAGGCCACCGACCTGCTAATCAAGACCTTTGTACAGACGCAATCGGCCCAGGTCCATGGTGGAAAAGGTACTAGGTTTACCCTTAGTG
AAGACATTTATCCTGAGAAGGGCTTGGGTGTAGAAGACCCTGTGGGTGAAGTCTCTGTCCATGTTGAGCTGTTCACTCATCCAGGAACTG
GGGAACACAAGGTCACAGTGAAAGTGGTGGCTGCCAATGACCTCAAGTGGCAGACTTCTGGCATCTTCCGGCCGTTCATCGAGGTCAACA
TCATTGGGCCCCAGCTCAGCGACAAGAAACGCAAGTTTGCGACCAAATCCAAGAACAATAGCTGGGCTCCCAAGTACAATGAGAGCTTCC
AGTTCACGCTGAGCGCCGACGCGGGTCCCGAGTGCTATGAGCTGCAGGTGTGCGTCAAGGACTACTGCTTCGCGCGCGAGGACCGCACGG
TGGGGCTGGCCGTGCTGCAGCTGCGTGAGCTGGCCCAGCGCGGGAGCGCCGCCTGCTGGCTGCCGCTCGGCCGCCGCATCCACATGGACG
ACACGGGCCTCACGGTGCTGCGAATCCTCTCGCAGCGCAGCAACGACGAGGTGGCCAAGGAGTTCGTGAAGCTCAAGTCGGACACGCGCT
CCGCCGAGGAGGGCGGTGCCGCGCCTGCGCCTTAGCGCGGGCGGTCGGCCGAGCGGCACTGCGCCTGCGCGGAGGGCGCTGGGCGGGGAG
GGACGGGGCTTGCGCCTTGGTGGGACCTCCCCAGGGGCGGGGCTCGGGGGGCTCCACGCCAAGGGTGGGCTGCGCCTACGCCCTTGACTC
AGCTTTCCCTTTTGGGGAATTAGGAATGGAGGATGCCCCGCCCTCTCGGGAGGCCACGCCCAAGGGCGCGACGAAGGAAGGAGCCACATC
CCCAACTTGAGGCCACGCCCCCAGCACCTAGGGGGCATTTTGAGCTGGGATGGGGGAAACCTCGTCCCTATGGAGGAGGCCACATCCCGG
GGCTCTGGTACCGGGAGGCACCACCTCATGTCCCCTGGAAAAGCCATAAGATGGGACCCAGACCCCTGGGACCCCAGACCAATTGCCAAG
TATGGAAATCTCAGCTCCCTCGAGGGGGGGCCCTGGGCAAGGGGTAGGGCTCTCTGGAGCGCCCCTCTAGGTGGCCTGGGGACTGGAGGG
ACCAGGATGCTGGTTGGAGGGCCCCGGAATACCGGAGTCCCTTTAGATATTTGTGCAAAAAATAAATGGGGGGAGGGGGGAGGATGGGAT
TTCAAAAGCACATGCGCCCTTGGGCGCCCAAACCCTGGGGGCCGAGGGGACGGCTCTGGTTCCCCACGCTGCCCCTACTTCCCTTTGGGA

>36923_36923_5_HMGCS1-UNC13A_HMGCS1_chr5_43292576_ENST00000325110_UNC13A_chr19_17756920_ENST00000551649_length(amino acids)=1035AA_BP=
MQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSG
EMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAM
RYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPA
SSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDF
WSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDR
VPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISN
VLLQYADIISKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVK
QMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRK
HGKGLEKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYA
LSLYTQATDLLIKTFVQTQSAQVHGGKGTRFTLSEDIYPEKGLGVEDPVGEVSVHVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPF
IEVNIIGPQLSDKKRKFATKSKNNSWAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRR

--------------------------------------------------------------
>36923_36923_6_HMGCS1-UNC13A_HMGCS1_chr5_43292576_ENST00000325110_UNC13A_chr19_17756920_ENST00000552293_length(transcript)=4823nt_BP=1680nt
GTCCCGCCTCCCAGCGACTCTCGGCGGTGCCGGAGTCGGGTGGGTTGGCGGCTATAAAGCTGGTGGCGAAGGGGAGGCGCCGCGGACTGT
CCTTTCGTGGCTCACTCCCTTTCCTCTGCTGCCGCTCGGTCACGCTTGTGCCCGAAGGAGGAAACAGTGACAGACCTGGAGACTGCAGTT
CTCTATCCTTCACACAGCTCTTTCACCATGCCTGGATCACTTCCTTTGAATGCAGAAGCTTGCTGGCCAAAAGATGTGGGAATTGTTGCC
CTTGAGATCTATTTTCCTTCTCAATATGTTGATCAAGCAGAGTTGGAAAAATATGATGGTGTAGATGCTGGAAAGTATACCATTGGCTTG
GGCCAGGCCAAGATGGGCTTCTGCACAGATAGAGAAGATATTAACTCTCTTTGCATGACTGTGGTTCAGAATCTTATGGAGAGAAATAAC
CTTTCCTATGATTGCATTGGGCGGCTGGAAGTTGGAACAGAGACAATCATCGACAAATCAAAGTCTGTGAAGACTAATTTGATGCAGCTG
TTTGAAGAGTCTGGGAATACAGATATAGAAGGAATCGACACAACTAATGCATGCTATGGAGGCACAGCTGCTGTCTTCAATGCTGTTAAC
TGGATTGAGTCCAGCTCTTGGGATGGACGGTATGCCCTGGTAGTTGCAGGAGATATTGCTGTATATGCCACAGGAAATGCTAGACCTACA
GGTGGAGTTGGAGCAGTAGCTCTGCTAATTGGGCCAAATGCTCCTTTAATTTTTGAACGAGGGCTTCGTGGGACACATATGCAACATGCC
TATGATTTTTACAAGCCTGATATGCTATCTGAATATCCTATAGTAGATGGAAAACTCTCCATACAGTGCTACCTCAGTGCATTAGACCGC
TGCTATTCTGTCTACTGCAAAAAGATCCATGCCCAGTGGCAGAAAGAGGGAAATGATAAAGATTTTACCTTGAATGATTTTGGCTTCATG
ATCTTTCACTCACCATATTGTAAACTGGTTCAGAAATCTCTAGCTCGGATGTTGCTGAATGACTTCCTTAATGACCAGAATAGAGATAAA
AATAGTATCTATAGTGGCCTGGAAGCCTTTGGGGATGTTAAATTAGAAGACACCTACTTTGATAGAGATGTGGAGAAGGCATTTATGAAG
GCTAGCTCTGAACTCTTCAGTCAGAAAACAAAGGCATCTTTACTTGTATCAAATCAAAATGGAAATATGTACACATCTTCAGTATATGGT
TCCCTTGCATCTGTTCTAGCACAGTACTCACCTCAGCAATTAGCAGGGAAGAGAATTGGAGTGTTTTCTTATGGTTCTGGTTTGGCTGCC
ACTCTGTACTCTCTTAAAGTCACACAAGATGCTACACCGGGGTCTGCTCTTGATAAAATAACAGCAAGTTTATGTGATCTTAAATCAAGG
CTTGATTCAAGAACTGGTGTGGCACCAGATGTCTTCGCTGAAAACATGAAGCTCAGAGAGGACACCCATCATTTGGTCAACTATATTCCC
CAGGGTTCAATAGATTCACTCTTTGAAGGAACGTGGTACTTAGTTAGGGTGGATGAAAAGCACAGAAGAACTTACGCTCGGCGTCCCACT
CCAAATGATGACACTTTGGATGAAGGAGTAGGACTTGTGCATTCAAACATAGCAACTGAGTGGTCTGCGCCCAGGGCTTGCAGGCAAAGG
ACAAGACAGGATCCAGTGACCCCTATGTCACCGTCCAGGTCGGGAAGACCAAGAAACGGACAAAAACCATCTATGGGAACCTCAACCCGG
TGTGGGAGGAGAATTTCCACTTTGAATGTCACAATTCCTCCGACCGCATCAAGGTGCGCGTCTGGGACGAGGATGACGACATCAAATCCC
GCGTGAAACAGAGGTTCAAGAGGGAATCTGACGATTTCCTGGGGCAGACGATCATTGAGGTGCGGACGCTCAGCGGCGAGATGGACGTGT
GGTACAACCTGGACAAGCGAACTGACAAATCTGCCGTGTCGGGTGCCATCCGGCTCCACATCAGTGTGGAGATCAAAGGCGAGGAGAAGG
TGGCCCCGTACCATGTCCAGTACACCTGTCTGCATGAGAACCTGTTCCACTTCGTGACCGACGTGCAGAACAATGGGGTCGTGAAGATCC
CAGATGCCAAGGGTGACGATGCCTGGAAGGTTTACTACGATGAGACAGCCCAGGAGATTGTGGACGAGTTTGCCATGCGCTACGGCGTCG
AGTCCATCTACCAAGCCATGACCCACTTTGCCTGCCTCTCCTCCAAGTATATGTGCCCAGGGGTGCCTGCCGTCATGAGCACCCTGCTCG
CCAACATCAATGCCTACTACGCACACACCACCGCCTCCACCAACGTGTCTGCCTCCGACCGCTTCGCCGCCTCCAACTTTGGGAAAGAGC
GCTTCGTGAAACTCCTGGACCAGCTGCATAACTCCCTGCGGATTGACCTCTCCATGTACCGGAATAACTTCCCAGCCAGCAGCCCGGAGA
GACTCCAGGACCTCAAATCCACTGTGGACCTTCTCACCAGCATCACCTTCTTTCGGATGAAGGTACAAGAACTCCAGAGCCCGCCCCGAG
CCAGCCAGGTGGTAAAGGACTGTGTGAAAGCCTGCCTTAATTCTACCTACGAGTACATCTTCAATAACTGCCATGAACTGTACAGCCGGG
AGTACCAGACAGACCCGGCCAAGAAGGGGGAAGTTCTCCCAGAGGAACAGGGGCCCAGCATCAAGAACCTCGACTTCTGGTCCAAGCTGA
TTACCCTCATAGTGTCCATCATTGAGGAAGACAAGAATTCCTACACTCCCTGCCTCAACCAGTTTCCCCAGGAGCTGAATGTGGGTAAAA
TCAGCGCTGAAGTGATGTGGAATCTGTTTGCCCAAGACATGAAGTACGCCATGGAGGAGCACGACAAGCATCGTCTATGCAAGAGTGCCG
ACTACATGAACCTCCACTTCAAGGTGAAATGGCTCTACAATGAGTATGTGACGGAACTTCCCGCCTTCAAGGACCGCGTGCCTGAGTACC
CTGCATGGTTTGAACCCTTCGTCATCCAGTGGCTGGATGAGAATGAGGAGGTGTCCCGGGATTTCCTGCACGGTGCCCTGGAGCGAGACA
AGAAGGATGGGTTCCAGCAGACCTCAGAGCATGCCCTATTCTCCTGCTCCGTGGTGGATGTTTTCTCCCAACTCAACCAGAGCTTTGAAA
TCATCAAGAAACTCGAGTGTCCCGACCCTCAGATCGTGGGGCACTACATGAGGCGCTTTGCCAAGACCATCAGTAATGTGCTCCTCCAGT
ATGCAGACATCATCTCCAAGGACTTTGCCTCCTACTGCTCCAAGGAGAAGGAGAAAGTGCCCTGCATTCTCATGAATAACACTCAACAGC
TACGAGTTCAGCTGGAGAAGATGTTCGAAGCCATGGGAGGAAAGGAGCTGGATGCTGAAGCCAGTGACATCCTGAAGGAGCTTCAGGTGA
AACTCAATAACGTCTTGGATGAGCTCAGCCGGGTGTTTGCTACCAGCTTCCAGCCGCACATTGAAGAGTGTGTCAAACAGATGGGTGACA
TCCTTAGCCAGGTTAAGGGCACAGGCAATGTGCCAGCCAGTGCCTGCAGCAGCGTGGCCCAGGACGCGGACAATGTGTTGCAGCCCATCA
TGGACCTGCTGGACAGCAACCTGACCCTCTTTGCCAAAATCTGTGAGAAGACTGTGCTGAAGCGAGTGCTGAAGGAGCTGTGGAAGCTGG
TTATGAACACCATGGAGAAAACCATCGTCCTGCCGCCCCTCACTGACCAGACGGGAACCCAGATGATCTTCAATGCAGCCAAGGAGCTGG
GTCAGCTGTCCAAACTCAAGGATCACATGGTACGAGAAGAAGCCAAGAGCTTGACCCCAAAGCAGTGCGCGGTTGTTGAGTTGGCCCTGG
ACACCATCAAGCAATATTTCCACGCGGGTGGCGTGGGCCTCAAGAAGACCTTCCTGGAGAAGAGCCCGGACCTGCAATCCTTGCGCTATG
CCCTGTCGCTCTACACGCAGGCCACCGACCTGCTAATCAAGACCTTTGTACAGACGCAATCGGCCCAGGTCCATGGTGGAAAAGGTACTA
GGTTTACCCTTAGTGAAGACATTTATCCTGAGAAGGGCTTGGGTGTAGAAGACCCTGTGGGTGAAGTCTCTGTCCATGTTGAGCTGTTCA
CTCATCCAGGAACTGGGGAACACAAGGTCACAGTGAAAGTGGTGGCTGCCAATGACCTCAAGTGGCAGACTTCTGGCATCTTCCGGCCGT
TCATCGAGGTCAACATCATTGGGCCCCAGCTCAGCGACAAGAAACGCAAGTTTGCGACCAAATCCAAGAACAATAGCTGGGCTCCCAAGT
ACAATGAGAGCTTCCAGTTCACGCTGAGCGCCGACGCGGGTCCCGAGTGCTATGAGCTGCAGGTGTGCGTCAAGGACTACTGCTTCGCGC
GCGAGGACCGCACGGTGGGGCTGGCCGTGCTGCAGCTGCGTGAGCTGGCCCAGCGCGGGAGCGCCGCCTGCTGGCTGCCGCTCGGCCGCC
GCATCCACATGGACGACACGGGCCTCACGGTGCTGCGAATCCTCTCGCAGCGCAGCAACGACGAGGTGGCCAAGGAGTTCGTGAAGCTCA
AGTCGGACACGCGCTCCGCCGAGGAGGGCGGTGCCGCGCCTGCGCCTTAGCGCGGGCGGTCGGCCGAGCGGCACTGCGCCTGCGCGGAGG

>36923_36923_6_HMGCS1-UNC13A_HMGCS1_chr5_43292576_ENST00000325110_UNC13A_chr19_17756920_ENST00000552293_length(amino acids)=1010AA_BP=
MQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSG
EMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAM
RYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPA
SSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDF
WSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDR
VPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISN
VLLQYADIISKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVK
QMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTGTQMIFNA
AKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQVHG
GKGTRFTLSEDIYPEKGLGVEDPVGEVSVHVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNS
WAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HMGCS1-UNC13A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for HMGCS1-UNC13A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for HMGCS1-UNC13A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source