FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:HMGXB3-PAM (FusionGDB2 ID:36970)

Fusion Gene Summary for HMGXB3-PAM

check button Fusion gene summary
Fusion gene informationFusion gene name: HMGXB3-PAM
Fusion gene ID: 36970
HgeneTgene
Gene symbol

HMGXB3

PAM

Gene ID

22993

23077

Gene nameHMG-box containing 3MYC binding protein 2
SynonymsHMGX3|SMFMyc-bp2|PAM|PHR1|Phr
Cytomap

5q32

13q22.3

Type of geneprotein-codingprotein-coding
DescriptionHMG domain-containing protein 3HMG box domain containing 3E3 ubiquitin-protein ligase MYCBP2HighwireMYC binding protein 2, E3 ubiquitin protein ligasePAM/Highwire/RPM-1 protein 1RING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Myc
Modification date2020031320200313
UniProtAcc

Q12766

.
Ensembl transtripts involved in fusion geneENST00000502717, ENST00000503427, 
ENST00000304400, ENST00000346918, 
ENST00000348126, ENST00000379787, 
ENST00000438793, ENST00000274392, 
ENST00000455264, ENST00000513648, 
Fusion gene scores* DoF score5 X 5 X 6=15010 X 12 X 3=360
# samples 710
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HMGXB3 [Title/Abstract] AND PAM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHMGXB3(149386210)-PAM(102237060), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePAM

GO:0016567

protein ubiquitination

29643511

TgenePAM

GO:0031398

positive regulation of protein ubiquitination

20534529


check buttonFusion gene breakpoints across HMGXB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PAM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A5KH-06AHMGXB3chr5

149386210

-PAMchr5

102201527

+
ChimerDB4SKCMTCGA-EB-A5KH-06AHMGXB3chr5

149386210

+PAMchr5

102237060

+


Top

Fusion Gene ORF analysis for HMGXB3-PAM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000502717ENST00000304400HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-5UTRENST00000502717ENST00000346918HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-5UTRENST00000502717ENST00000348126HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-5UTRENST00000502717ENST00000348126HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-5UTRENST00000502717ENST00000379787HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-5UTRENST00000502717ENST00000379787HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-5UTRENST00000502717ENST00000438793HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-5UTRENST00000503427ENST00000304400HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-5UTRENST00000503427ENST00000346918HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-5UTRENST00000503427ENST00000348126HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-5UTRENST00000503427ENST00000348126HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-5UTRENST00000503427ENST00000379787HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-5UTRENST00000503427ENST00000379787HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-5UTRENST00000503427ENST00000438793HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-intronENST00000502717ENST00000274392HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-intronENST00000502717ENST00000274392HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-intronENST00000502717ENST00000304400HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-intronENST00000502717ENST00000455264HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-intronENST00000502717ENST00000455264HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-intronENST00000502717ENST00000513648HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-intronENST00000502717ENST00000513648HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-intronENST00000503427ENST00000274392HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-intronENST00000503427ENST00000274392HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-intronENST00000503427ENST00000304400HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-intronENST00000503427ENST00000455264HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-intronENST00000503427ENST00000455264HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-intronENST00000503427ENST00000513648HMGXB3chr5

149386210

-PAMchr5

102201527

+
5CDS-intronENST00000503427ENST00000513648HMGXB3chr5

149386210

+PAMchr5

102237060

+
In-frameENST00000502717ENST00000346918HMGXB3chr5

149386210

+PAMchr5

102237060

+
In-frameENST00000502717ENST00000438793HMGXB3chr5

149386210

+PAMchr5

102237060

+
In-frameENST00000503427ENST00000346918HMGXB3chr5

149386210

+PAMchr5

102237060

+
In-frameENST00000503427ENST00000438793HMGXB3chr5

149386210

+PAMchr5

102237060

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000503427HMGXB3chr5149386210+ENST00000438793PAMchr5102237060+5925117315338841243
ENST00000503427HMGXB3chr5149386210+ENST00000346918PAMchr5102237060+3806117315336261157
ENST00000502717HMGXB3chr5149386210+ENST00000438793PAMchr5102237060+55287768634871133
ENST00000502717HMGXB3chr5149386210+ENST00000346918PAMchr5102237060+34097768632291047

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000503427ENST00000438793HMGXB3chr5149386210+PAMchr5102237060+0.0003600370.99964
ENST00000503427ENST00000346918HMGXB3chr5149386210+PAMchr5102237060+0.0002721350.9997279
ENST00000502717ENST00000438793HMGXB3chr5149386210+PAMchr5102237060+0.0002038190.9997962
ENST00000502717ENST00000346918HMGXB3chr5149386210+PAMchr5102237060+0.0001986060.99980146

Top

Fusion Genomic Features for HMGXB3-PAM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HMGXB3chr5149386210+PAMchr5102237059+0.0028152990.9971847
HMGXB3chr5149386210+PAMchr5102237059+0.0028152990.9971847

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for HMGXB3-PAM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:149386210/chr5:102237060)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HMGXB3

Q12766

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePAMchr5:149386210chr5:102237060ENST00000304400125495_81770975.0RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:149386210chr5:102237060ENST00000346918123495_81770888.0RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:149386210chr5:102237060ENST00000348126124495_81770867.0RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:149386210chr5:102237060ENST00000438793125495_81770974.0RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:149386210chr5:102237060ENST00000455264124495_81770906.0RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:149386210chr5:102237060ENST00000304400125498_54170975.0RepeatNote=NHL 1
TgenePAMchr5:149386210chr5:102237060ENST00000304400125567_60870975.0RepeatNote=NHL 2
TgenePAMchr5:149386210chr5:102237060ENST00000304400125617_66270975.0RepeatNote=NHL 3
TgenePAMchr5:149386210chr5:102237060ENST00000304400125670_71470975.0RepeatNote=NHL 4
TgenePAMchr5:149386210chr5:102237060ENST00000304400125766_80970975.0RepeatNote=NHL 5
TgenePAMchr5:149386210chr5:102237060ENST00000346918123498_54170888.0RepeatNote=NHL 1
TgenePAMchr5:149386210chr5:102237060ENST00000346918123567_60870888.0RepeatNote=NHL 2
TgenePAMchr5:149386210chr5:102237060ENST00000346918123617_66270888.0RepeatNote=NHL 3
TgenePAMchr5:149386210chr5:102237060ENST00000346918123670_71470888.0RepeatNote=NHL 4
TgenePAMchr5:149386210chr5:102237060ENST00000346918123766_80970888.0RepeatNote=NHL 5
TgenePAMchr5:149386210chr5:102237060ENST00000348126124498_54170867.0RepeatNote=NHL 1
TgenePAMchr5:149386210chr5:102237060ENST00000348126124567_60870867.0RepeatNote=NHL 2
TgenePAMchr5:149386210chr5:102237060ENST00000348126124617_66270867.0RepeatNote=NHL 3
TgenePAMchr5:149386210chr5:102237060ENST00000348126124670_71470867.0RepeatNote=NHL 4
TgenePAMchr5:149386210chr5:102237060ENST00000348126124766_80970867.0RepeatNote=NHL 5
TgenePAMchr5:149386210chr5:102237060ENST00000438793125498_54170974.0RepeatNote=NHL 1
TgenePAMchr5:149386210chr5:102237060ENST00000438793125567_60870974.0RepeatNote=NHL 2
TgenePAMchr5:149386210chr5:102237060ENST00000438793125617_66270974.0RepeatNote=NHL 3
TgenePAMchr5:149386210chr5:102237060ENST00000438793125670_71470974.0RepeatNote=NHL 4
TgenePAMchr5:149386210chr5:102237060ENST00000438793125766_80970974.0RepeatNote=NHL 5
TgenePAMchr5:149386210chr5:102237060ENST00000455264124498_54170906.0RepeatNote=NHL 1
TgenePAMchr5:149386210chr5:102237060ENST00000455264124567_60870906.0RepeatNote=NHL 2
TgenePAMchr5:149386210chr5:102237060ENST00000455264124617_66270906.0RepeatNote=NHL 3
TgenePAMchr5:149386210chr5:102237060ENST00000455264124670_71470906.0RepeatNote=NHL 4
TgenePAMchr5:149386210chr5:102237060ENST00000455264124766_80970906.0RepeatNote=NHL 5
TgenePAMchr5:149386210chr5:102237060ENST00000304400125888_97370975.0Topological domainCytoplasmic
TgenePAMchr5:149386210chr5:102237060ENST00000346918123888_97370888.0Topological domainCytoplasmic
TgenePAMchr5:149386210chr5:102237060ENST00000348126124888_97370867.0Topological domainCytoplasmic
TgenePAMchr5:149386210chr5:102237060ENST00000438793125888_97370974.0Topological domainCytoplasmic
TgenePAMchr5:149386210chr5:102237060ENST00000455264124888_97370906.0Topological domainCytoplasmic
TgenePAMchr5:149386210chr5:102237060ENST00000304400125864_88770975.0TransmembraneHelical
TgenePAMchr5:149386210chr5:102237060ENST00000346918123864_88770888.0TransmembraneHelical
TgenePAMchr5:149386210chr5:102237060ENST00000348126124864_88770867.0TransmembraneHelical
TgenePAMchr5:149386210chr5:102237060ENST00000438793125864_88770974.0TransmembraneHelical
TgenePAMchr5:149386210chr5:102237060ENST00000455264124864_88770906.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHMGXB3chr5:149386210chr5:102237060ENST00000502717+3201523_15321041293.0Compositional biasNote=Poly-Glu
HgeneHMGXB3chr5:149386210chr5:102237060ENST00000502717+320276_2821041293.0Compositional biasNote=Poly-Lys
HgeneHMGXB3chr5:149386210chr5:102237060ENST00000502717+320518_5241041293.0Compositional biasNote=Poly-Ser
HgeneHMGXB3chr5:149386210chr5:102237060ENST00000502717+32062_2391041293.0Compositional biasNote=Arg-rich
HgeneHMGXB3chr5:149386210chr5:102237060ENST00000502717+320288_3561041293.0DNA bindingHMG box
TgenePAMchr5:149386210chr5:102237060ENST000003044001251_49470975.0RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:149386210chr5:102237060ENST000003469181231_49470888.0RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:149386210chr5:102237060ENST000003481261241_49470867.0RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:149386210chr5:102237060ENST000004387931251_49470974.0RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:149386210chr5:102237060ENST000004552641241_49470906.0RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:149386210chr5:102237060ENST0000030440012531_86370975.0Topological domainIntragranular
TgenePAMchr5:149386210chr5:102237060ENST0000034691812331_86370888.0Topological domainIntragranular
TgenePAMchr5:149386210chr5:102237060ENST0000034812612431_86370867.0Topological domainIntragranular
TgenePAMchr5:149386210chr5:102237060ENST0000043879312531_86370974.0Topological domainIntragranular
TgenePAMchr5:149386210chr5:102237060ENST0000045526412431_86370906.0Topological domainIntragranular


Top

Fusion Gene Sequence for HMGXB3-PAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36970_36970_1_HMGXB3-PAM_HMGXB3_chr5_149386210_ENST00000502717_PAM_chr5_102237060_ENST00000346918_length(transcript)=3409nt_BP=776nt
GCCGGGACGGGTCTCCCTGGCGATCCGTGGTGTGCCGCTACTGCCGGTGCAGCCGCCAAACCGGTGCCTCGGTGACGACCGTGTCCCTGC
CGTCTTCCTCGAGCTCCCCGGGGCTTGACCCCCGGGGCCCTCGGCAGGCATCGGTGAGGAGCCTGCGGAGCGAACCTGTGCTCCTATTCT
TGCCCTTCAGGACCCCATATCGCGACTCCGAGGAGGGGAAGCGAGAGGGGCTGTCGCGACTCCGCGCCGTGTGTCGCCGGGCGGGGCCGC
GGGGCCGGGGCTCCTTCAGCCCCCGGGATGCGCGCGCGAGCCCTCGCCTCCACTTCCTTGTTGCTGCTGTCACGACTGGAGCCGCCTCTC
GCCGACAGCGGGGAGCGCGAGTGCGCCAGCCATCCCCCTCGTCCAGCCGCCGGGCCAAGCGCCTCCGGGAATGTGAGCGGCGCAGCTTGC
ACGCTCCTCCGGCCATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTGATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTC
CTGGGCCACCCAAGAAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAGAAACCCAGGTCTGCTTACCTTCTGTACTATTACGACA
TCTACCTGAAAGTGCAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAATAAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGG
CCGAGAGGAGTTACTACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGATCCTTCCGATACATACTTCTGCATGTCTATGCGAATAC
CAGTGGATGAGGAAGCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGATACTGTCCATCACATGTTACTTTTTGGATGCAATATGC
CTTCATCCACTGGAAGTTACTGGTTTTGTGATGAAGGAACCTGTACAGATAAAGCCAATATTCTGTATGCCTGGGCGAGAAATGCTCCCC
CTACCCGGCTCCCCAAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGTAAATACTTTGTACTACAGGTACACTATGGGGATATTA
GTGCTTTTAGAGATAATAACAAGGACTGTTCTGGTGTGTCCTTACACCTCACACGTCTGCCACAGCCTTTAATTGCTGGCATGTACCTTA
TGATGTCTGTTGACACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGACATTTCATGCCATTATAAAAATTATCCAATGCATGTCT
TTGCCTATAGAGTTCACACTCACCATTTAGGTAAGGTAGTAAGTGGATACAGAGTAAGAAATGGACAGTGGACACTGATTGGACGGCAGA
GCCCTCAGCTGCCACAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGTTTTGGTGACCTACTGGCTGCAAGATGTGTATTCACTG
GTGAAGGAAGGACAGAAGCCACACACATTGGTGGCACGTCTAGTGATGAAATGTGCAACTTATACATTATGTATTACATGGAAGCCAAGC
ATGCAGTTTCTTTCATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGAACCATACCACCAGAGGCCAACATTCCAATTCCCGTGA
AGTCTGATATGGTTATGATGCATGAACATCATAAAGAAACAGAATATAAAGATAAGATTCCTTTACTACAGCAGCCAAAACGAGAAGAAG
AAGAAGTGTTAGACCAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGAGAAAGGGAAGATGTTGTTCATGTGCACAAATATAATC
CTACAGAAAAGGCAGAATCAGAGTCAGACCTGGTAGCTGAGATTGCAAATGTAGTCCAAAAAAAGGATCTTGGTCGATCTGATGCCAGAG
AGGGTGCAGAACATGAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCACAAATTCCACAGACTAGTATCTACCTTGAGGCCACCAG
AGAGCAGAGTTTTCTCATTACAGCAGCCCCCACCTGGTGAAGGCACCTGGGAACCAGAACACACAGGAGATTTCCACATGGAAGAGGCAC
TGGATTGGCCTGGAGTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTAGACCCTAAGAATAACCTGGTGATTTTCCACAGAGGTG
ACCATGTCTGGGATGGAAACTCGTTTGACAGCAAGTTTGTTTACCAGCAAATAGGACTCGGACCAATTGAAGAAGACACTATTCTTGTCA
TAGATCCAAATAATGCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTTTTACTTGCCACATGGCTTGAGTATAGATAAAGATGGGAATT
ATTGGGTCACAGACGTGGCTCTCCATCAGGTGTTCAAACTGGATCCAAACAATAAAGAAGGCCCTGTATTAATCCTGGGAAGGAGCATGC
AACCAGGCAGTGACCAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGATCCAGGCACTGGAGCCATTTATGTATCAGATGGTTACT
GCAACAGCAGGATTGTGCAGTTTTCACCAAGTGGAAAGTTCATCACACAGTGGGGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCAGGCC
AGTTCACTGTTCCTCACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGTGTGGCAGACCGGGAAAATGGTCGGATCCAGTGTTTTA
AAACTGACACCAAAGAATTTGTGAGAGAGATTAAGCATTCATCATTTGGAAGAAATGTATTTGCAATTTCATATATACCAGGCTTGCTCT
TTGCAGTGAATGGGAAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTTGTGATGAACTTTTCCAATGGGGAAATTATAGACATCT
TCAAGCCAGTGCGCAAGCACTTTGATATGCCTCATGATATTGTTGCATCTGAAGATGGGACTGTGTACATTGGAGATGCTCATACCAACA
CCGTGTGGAAGTTCACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAGGCTGGCATTGAGGTCCAGGAAATCAAAGGAAAGGGAA
GTGGAGGCTTAAACCTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGACCGGCTTAGCACTGAGGGCAGTGACC
AAGAGAAAGAGGATGATGGAAGTGAATCAGAAGAGGAGTATTCAGCACCTCTGCCTGCGCTCGCACCTTCCTCCTCCTGAAAACCAAGCT
TTGATTTAGATTGAGTAAGATTTACCCAGAATGTCAGATTCCTTTCCCTTTAGCACGTTTAAAGTTCTGTGTATTTAATTGTAAACTGTA

>36970_36970_1_HMGXB3-PAM_HMGXB3_chr5_149386210_ENST00000502717_PAM_chr5_102237060_ENST00000346918_length(amino acids)=1047AA_BP=230
MPSSSSSPGLDPRGPRQASVRSLRSEPVLLFLPFRTPYRDSEEGKREGLSRLRAVCRRAGPRGRGSFSPRDARASPRLHFLVAAVTTGAA
SRRQRGARVRQPSPSSSRRAKRLRECERRSLHAPPAMDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKKPRSAYLLYYY
DIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGLDPSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCN
MPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMY
LMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVF
TGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQQPKRE
EEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESESDLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRP
PESRVFSLQQPPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQQIGLGPIEEDTIL
VIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDG
YCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIKHSSFGRNVFAISYIPGL
LFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKGK

--------------------------------------------------------------
>36970_36970_2_HMGXB3-PAM_HMGXB3_chr5_149386210_ENST00000502717_PAM_chr5_102237060_ENST00000438793_length(transcript)=5528nt_BP=776nt
GCCGGGACGGGTCTCCCTGGCGATCCGTGGTGTGCCGCTACTGCCGGTGCAGCCGCCAAACCGGTGCCTCGGTGACGACCGTGTCCCTGC
CGTCTTCCTCGAGCTCCCCGGGGCTTGACCCCCGGGGCCCTCGGCAGGCATCGGTGAGGAGCCTGCGGAGCGAACCTGTGCTCCTATTCT
TGCCCTTCAGGACCCCATATCGCGACTCCGAGGAGGGGAAGCGAGAGGGGCTGTCGCGACTCCGCGCCGTGTGTCGCCGGGCGGGGCCGC
GGGGCCGGGGCTCCTTCAGCCCCCGGGATGCGCGCGCGAGCCCTCGCCTCCACTTCCTTGTTGCTGCTGTCACGACTGGAGCCGCCTCTC
GCCGACAGCGGGGAGCGCGAGTGCGCCAGCCATCCCCCTCGTCCAGCCGCCGGGCCAAGCGCCTCCGGGAATGTGAGCGGCGCAGCTTGC
ACGCTCCTCCGGCCATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTGATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTC
CTGGGCCACCCAAGAAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAGAAACCCAGGTCTGCTTACCTTCTGTACTATTACGACA
TCTACCTGAAAGTGCAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAATAAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGG
CCGAGAGGAGTTACTACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGATCCTTCCGATACATACTTCTGCATGTCTATGCGAATAC
CAGTGGATGAGGAAGCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGATACTGTCCATCACATGTTACTTTTTGGATGCAATATGC
CTTCATCCACTGGAAGTTACTGGTTTTGTGATGAAGGAACCTGTACAGATAAAGCCAATATTCTGTATGCCTGGGCGAGAAATGCTCCCC
CTACCCGGCTCCCCAAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGTAAATACTTTGTACTACAGGTACACTATGGGGATATTA
GTGCTTTTAGAGATAATAACAAGGACTGTTCTGGTGTGTCCTTACACCTCACACGTCTGCCACAGCCTTTAATTGCTGGCATGTACCTTA
TGATGTCTGTTGACACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGACATTTCATGCCATTATAAAAATTATCCAATGCATGTCT
TTGCCTATAGAGTTCACACTCACCATTTAGGTAAGGTAGTAAGTGGATACAGAGTAAGAAATGGACAGTGGACACTGATTGGACGGCAGA
GCCCTCAGCTGCCACAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGTTTTGGTGACCTACTGGCTGCAAGATGTGTATTCACTG
GTGAAGGAAGGACAGAAGCCACACACATTGGTGGCACGTCTAGTGATGAAATGTGCAACTTATACATTATGTATTACATGGAAGCCAAGC
ATGCAGTTTCTTTCATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGAACCATACCACCAGAGGCCAACATTCCAATTCCCGTGA
AGTCTGATATGGTTATGATGCATGAACATCATAAAGAAACAGAATATAAAGATAAGATTCCTTTACTACAGCAGCCAAAACGAGAAGAAG
AAGAAGTGTTAGACCAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGAGAAAGGGAAGATGTTGTTCATGTGCACAAATATAATC
CTACAGAAAAGGCAGAATCAGAGTCAGACCTGGTAGCTGAGATTGCAAATGTAGTCCAAAAAAAGGATCTTGGTCGATCTGATGCCAGAG
AGGGTGCAGAACATGAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCACAAATTCCACAGACTAGTATCTACCTTGAGGCCACCAG
AGAGCAGAGTTTTCTCATTACAGCAGCCCCCACCTGGTGAAGGCACCTGGGAACCAGAACACACAGGAGATTTCCACATGGAAGAGGCAC
TGGATTGGCCTGGAGTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTAGACCCTAAGAATAACCTGGTGATTTTCCACAGAGGTG
ACCATGTCTGGGATGGAAACTCGTTTGACAGCAAGTTTGTTTACCAGCAAATAGGACTCGGACCAATTGAAGAAGACACTATTCTTGTCA
TAGATCCAAATAATGCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTTTTACTTGCCACATGGCTTGAGTATAGATAAAGATGGGAATT
ATTGGGTCACAGACGTGGCTCTCCATCAGGTGTTCAAACTGGATCCAAACAATAAAGAAGGCCCTGTATTAATCCTGGGAAGGAGCATGC
AACCAGGCAGTGACCAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGATCCAGGCACTGGAGCCATTTATGTATCAGATGGTTACT
GCAACAGCAGGATTGTGCAGTTTTCACCAAGTGGAAAGTTCATCACACAGTGGGGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCAGGCC
AGTTCACTGTTCCTCACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGTGTGGCAGACCGGGAAAATGGTCGGATCCAGTGTTTTA
AAACTGACACCAAAGAATTTGTGAGAGAGATTAAGCATTCATCATTTGGAAGAAATGTATTTGCAATTTCATATATACCAGGCTTGCTCT
TTGCAGTGAATGGGAAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTTGTGATGAACTTTTCCAATGGGGAAATTATAGACATCT
TCAAGCCAGTGCGCAAGCACTTTGATATGCCTCATGATATTGTTGCATCTGAAGATGGGACTGTGTACATTGGAGATGCTCATACCAACA
CCGTGTGGAAGTTCACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAGGCTGGCATTGAGGTCCAGGAAATCAAAGAAGCCGAGG
CAGTTGTTGAAACCAAAATGGAGAACAAACCCACCTCCTCAGAATTGCAGAAGATGCAAGAGAAACAGAAACTGATCAAAGAGCCAGGCT
CGGGAGTGCCTGTTGTTCTCATTACAACCCTTCTGGTTATTCCGGTGGTTGTCCTGCTGGCCATTGCCATATTTATTCGGTGGAAAAAAT
CAAGGGCCTTTGGAGATTCTGAACACAAACTCGAGACGAGTTCAGGAAGAGTACTGGGAAGATTTAGAGGAAAGGGAAGTGGAGGCTTAA
ACCTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGACCGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGG
ATGATGGAAGTGAATCAGAAGAGGAGTATTCAGCACCTCTGCCTGCGCTCGCACCTTCCTCCTCCTGAAAACCAAGCTTTGATTTAGATT
GAGTAAGATTTACCCAGAATGTCAGATTCCTTTCCCTTTAGCACGTTTAAAGTTCTGTGTATTTAATTGTAAACTGTACTAGTCTGTGTG
GGACTGTACACACTTTATTTACTTCGTTTTGGTTAAGTTGGCTTCTGTTTCTAGTTGAGGAGTTTCCTAAAAGTTCATAACAGTGCCATT
GTCTTTATATGAACATAGACTAGAGAAACCGTCCTCTTTTTCCATCATAATTCTAATCTAACAATGGAAGATTTGCCCATTTACACTTTT
GAGACTTTTTGGTGGATGTAAATAACCCCATTCTTTGCTTGAACACAGTATTTTCCCAATAGCACTTTCATTGCCAGTGTCTTTCTTTGG
TGCCTTTCCTGTTCAGCATTCTTAGCCTGTGGCAGTAAAGAGAAACTTTGTGCTACATGACGACAAAGCTGCTAAATCTCCTATTTTTTT
AAAATCACTAACATTATATTGCAATGAAGGAAATAAAAAAGTCTCTATTTAAATTCTTTTTTAAATTTTCTTCAGTTGGTGTGTTTTTGG
GATGTCTTATTTTTAGATGGTTACACTGTTAGAACACTATTTTCAGAATCTGAATGTAATTTGTGTAATAAAGTGTTTTCAGAGCATTAG
CTGTCAGTGTATTTTCCAGTTTTTGCGTATTTGCAGATTTTACATACAACTTTTATAATAATTACACAAACCCACAAATATTAGTGAAAC
TTACTCGATGTCTTCAACTAAAAGAAATGTGTGTATTGTACAAAATTTAGAAGATACTTTAGCCAATATAAATTAAAAACCAGCCTGAGT
TTACATAAATTTGTAAAGTCAGGCTCTTCTAAAATCCAAAGAGGGTTTTTGCCTATATATCAATCAGAGGATAAATACTTTAATAAAAGG
TAATCACAGCTAAGTGGATACCTGTGTCTCAAATTACATATGCAAATGATCCATCAGTAGGGATCACTAATAATAGTTTTCCTTTTAAAA
AATAATTTCAGGGCAGGTACAGTGGCTCAAGCCTATACTTCCAGGACTTTGGGAGGCCAAGCAGAAGGATTGTGGGAGGCCAAGCAGAAG
GATTGTTTGAGCCCAGAAATTCAAGGCTGCAGTGAGCTATGATCAATCCACTGTACTCCAGCCTAGGCTACAGAGTGAGATCCTTTCTCT
AAAATAAAATACAATTTCCATGTATCCATAGGAATATATTCATCTTTTACAGTGATTGCAGATTAGTTTTAAAACGTCTTTTTCGTAATT
CGTCAATGCAAGTTAGTAAGAACCAGATAATTTTCCATTTTAAAATGATAGGAATCTAAAACTCTTTTTCAAAAATGCCAACCTGTTTTT
CCGGCATCATAGTAGTTGGAATAATACAGATATAATTGACTAATCATAAAGTACATGAGAGTACAGAAGGGAAATTTGGAAACGGTAAGT
CTGCTAGGGCATTACAATCCTGTCCTAGCACTCCACCTTTATTCTGCCAACCTGGGTTAATTAAAGATGGTAGCCTGGAAAGTAATGAAT
GACATTGACTTCAGGCAATCTTTCCACTGATTATTCTTGGCTGAACTTCATTTATCGAGTCAGAGAATGCACTGCCTGAGAAATGTCCCA
GAGGAGTGAATCCTAGGCCTGGCCACAGTAGAATCGCCTGGAGAATTTAAGAAAAAAATTGTTGGGCACTCACTCTTTCCAGTGATCTTT
ATTTAGTTGGCTTACAATGGAATACAGGTATGGTTCATGTTTTTAAATTTGTCCAGGTGTTTCTATTGTGCAGTCACAGTTGAAAACCAT
TGTCTTCGAGAATAGCTATTCTATCTTGCCAGTTACAATAAGTGGATAGCTATATTTTCACATAAATTATAGTTTACAGATGTTTGGAGG
GGGAAGACAGGATCTGAGGTGTTTTGATATGACTGTTAGCACCAAAATCTGAATGCCTTAATTGTTGAATGTGTTAAATTGGATAATTAA

>36970_36970_2_HMGXB3-PAM_HMGXB3_chr5_149386210_ENST00000502717_PAM_chr5_102237060_ENST00000438793_length(amino acids)=1133AA_BP=230
MPSSSSSPGLDPRGPRQASVRSLRSEPVLLFLPFRTPYRDSEEGKREGLSRLRAVCRRAGPRGRGSFSPRDARASPRLHFLVAAVTTGAA
SRRQRGARVRQPSPSSSRRAKRLRECERRSLHAPPAMDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKKPRSAYLLYYY
DIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGLDPSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCN
MPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMY
LMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVF
TGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQQPKRE
EEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESESDLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRP
PESRVFSLQQPPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQQIGLGPIEEDTIL
VIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDG
YCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIKHSSFGRNVFAISYIPGL
LFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEA
EAVVETKMENKPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEHKLETSSGRVLGRFRGKGSGG

--------------------------------------------------------------
>36970_36970_3_HMGXB3-PAM_HMGXB3_chr5_149386210_ENST00000503427_PAM_chr5_102237060_ENST00000346918_length(transcript)=3806nt_BP=1173nt
ATGAGAGGGAAAGACTGAGACAGGCTGAGGTCAGGCCTTGAACGTCGTGCTGAGGAGAGGGTGGTATTGTAGGCTTCCCAGCGCCCGACG
TGGCTCTGAAAGGTGAGGCGGGGCCTAGATCCCTCACGCTCAGCACAGCCCCGCCCCTGTTACCTGAACGCCCCACAGCAGTGCCCGGGG
GCTGAGCGGCCGGGGCGTCCCACCGCCGGCAGCCACAGCTTCCTCCTCCGCCCGGGACCTCTGGCCGGAAGCAGTCCGTTCGCCTTACTA
GACCCGCTCCAAGCCTTTGAGCAGTTCGTGTGGGTCCGCTCCCAAGCTAGGGCTGGGCTGTTGCGCTTGCGCCAGGGGTCGCATGCAGTC
ACGCGCTGCCGACCGCTTCCGGTGCGCCGCGAGGGCCGCCGGGACGGGTCTCCCTGGCGATCCGTGGTGTGCCGCTACTGCCGGTGCAGC
CGCCAAACCGGTGCCTCGGTGACGACCGTGTCCCTGCCGTCTTCCTCGAGCTCCCCGGGGCTTGACCCCCGGGGCCCTCGGCAGGCATCG
GTGAGGAGCCTGCGGAGCGAACCTGTGCTCCTATTCTTGCCCTTCAGGACCCCATATCGCGACTCCGAGGAGGGGAAGCGAGAGGGGCTG
TCGCGACTCCGCGCCGTGTGTCGCCGGGCGGGGCCGCGGGGCCGGGGCTCCTTCAGCCCCCGGGATGCGCGCGCGAGCCCTCGCCTCCAC
TTCCTTGTTGCTGCTGTCACGACTGGAGCCGCCTCTCGCCGACAGCGGGGAGCGCGAGTGCGCCAGCCATCCCCCTCGTCCAGCCGCCGG
GCCAAGCGCCTCCGGGAATGTGAGCGGCGCAGCTTGCACGCTCCTCCGGCCATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTG
ATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTCCTGGGCCACCCAAGAAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAG
AAACCCAGGTCTGCTTACCTTCTGTACTATTACGACATCTACCTGAAAGTGCAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAAT
AAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGGCCGAGAGGAGTTACTACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGAT
CCTTCCGATACATACTTCTGCATGTCTATGCGAATACCAGTGGATGAGGAAGCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGAT
ACTGTCCATCACATGTTACTTTTTGGATGCAATATGCCTTCATCCACTGGAAGTTACTGGTTTTGTGATGAAGGAACCTGTACAGATAAA
GCCAATATTCTGTATGCCTGGGCGAGAAATGCTCCCCCTACCCGGCTCCCCAAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGT
AAATACTTTGTACTACAGGTACACTATGGGGATATTAGTGCTTTTAGAGATAATAACAAGGACTGTTCTGGTGTGTCCTTACACCTCACA
CGTCTGCCACAGCCTTTAATTGCTGGCATGTACCTTATGATGTCTGTTGACACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGAC
ATTTCATGCCATTATAAAAATTATCCAATGCATGTCTTTGCCTATAGAGTTCACACTCACCATTTAGGTAAGGTAGTAAGTGGATACAGA
GTAAGAAATGGACAGTGGACACTGATTGGACGGCAGAGCCCTCAGCTGCCACAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGT
TTTGGTGACCTACTGGCTGCAAGATGTGTATTCACTGGTGAAGGAAGGACAGAAGCCACACACATTGGTGGCACGTCTAGTGATGAAATG
TGCAACTTATACATTATGTATTACATGGAAGCCAAGCATGCAGTTTCTTTCATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGA
ACCATACCACCAGAGGCCAACATTCCAATTCCCGTGAAGTCTGATATGGTTATGATGCATGAACATCATAAAGAAACAGAATATAAAGAT
AAGATTCCTTTACTACAGCAGCCAAAACGAGAAGAAGAAGAAGTGTTAGACCAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGA
GAAAGGGAAGATGTTGTTCATGTGCACAAATATAATCCTACAGAAAAGGCAGAATCAGAGTCAGACCTGGTAGCTGAGATTGCAAATGTA
GTCCAAAAAAAGGATCTTGGTCGATCTGATGCCAGAGAGGGTGCAGAACATGAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCAC
AAATTCCACAGACTAGTATCTACCTTGAGGCCACCAGAGAGCAGAGTTTTCTCATTACAGCAGCCCCCACCTGGTGAAGGCACCTGGGAA
CCAGAACACACAGGAGATTTCCACATGGAAGAGGCACTGGATTGGCCTGGAGTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTA
GACCCTAAGAATAACCTGGTGATTTTCCACAGAGGTGACCATGTCTGGGATGGAAACTCGTTTGACAGCAAGTTTGTTTACCAGCAAATA
GGACTCGGACCAATTGAAGAAGACACTATTCTTGTCATAGATCCAAATAATGCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTTTTAC
TTGCCACATGGCTTGAGTATAGATAAAGATGGGAATTATTGGGTCACAGACGTGGCTCTCCATCAGGTGTTCAAACTGGATCCAAACAAT
AAAGAAGGCCCTGTATTAATCCTGGGAAGGAGCATGCAACCAGGCAGTGACCAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGAT
CCAGGCACTGGAGCCATTTATGTATCAGATGGTTACTGCAACAGCAGGATTGTGCAGTTTTCACCAAGTGGAAAGTTCATCACACAGTGG
GGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCAGGCCAGTTCACTGTTCCTCACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGT
GTGGCAGACCGGGAAAATGGTCGGATCCAGTGTTTTAAAACTGACACCAAAGAATTTGTGAGAGAGATTAAGCATTCATCATTTGGAAGA
AATGTATTTGCAATTTCATATATACCAGGCTTGCTCTTTGCAGTGAATGGGAAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTT
GTGATGAACTTTTCCAATGGGGAAATTATAGACATCTTCAAGCCAGTGCGCAAGCACTTTGATATGCCTCATGATATTGTTGCATCTGAA
GATGGGACTGTGTACATTGGAGATGCTCATACCAACACCGTGTGGAAGTTCACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAG
GCTGGCATTGAGGTCCAGGAAATCAAAGGAAAGGGAAGTGGAGGCTTAAACCTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGA
AAAGGGTTTGACCGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGGATGATGGAAGTGAATCAGAAGAGGAGTATTCAGCACCTCTG
CCTGCGCTCGCACCTTCCTCCTCCTGAAAACCAAGCTTTGATTTAGATTGAGTAAGATTTACCCAGAATGTCAGATTCCTTTCCCTTTAG
CACGTTTAAAGTTCTGTGTATTTAATTGTAAACTGTACTAGTCTGTGTGGGACTGTACACACTTTATTTACTTCGTTTTGGTTAAGTTGG

>36970_36970_3_HMGXB3-PAM_HMGXB3_chr5_149386210_ENST00000503427_PAM_chr5_102237060_ENST00000346918_length(amino acids)=1157AA_BP=340
MNAPQQCPGAERPGRPTAGSHSFLLRPGPLAGSSPFALLDPLQAFEQFVWVRSQARAGLLRLRQGSHAVTRCRPLPVRREGRRDGSPWRS
VVCRYCRCSRQTGASVTTVSLPSSSSSPGLDPRGPRQASVRSLRSEPVLLFLPFRTPYRDSEEGKREGLSRLRAVCRRAGPRGRGSFSPR
DARASPRLHFLVAAVTTGAASRRQRGARVRQPSPSSSRRAKRLRECERRSLHAPPAMDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKK
YKIHGEKTKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGLDPSDTYFCMSMRIPVDEEAFVI
DFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKD
CSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFY
PVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHE
HHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESESDLVAEIANVVQKKDLGRSDAREGAEHERGN
AILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSF
DSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHF
CQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVR
EIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTE

--------------------------------------------------------------
>36970_36970_4_HMGXB3-PAM_HMGXB3_chr5_149386210_ENST00000503427_PAM_chr5_102237060_ENST00000438793_length(transcript)=5925nt_BP=1173nt
ATGAGAGGGAAAGACTGAGACAGGCTGAGGTCAGGCCTTGAACGTCGTGCTGAGGAGAGGGTGGTATTGTAGGCTTCCCAGCGCCCGACG
TGGCTCTGAAAGGTGAGGCGGGGCCTAGATCCCTCACGCTCAGCACAGCCCCGCCCCTGTTACCTGAACGCCCCACAGCAGTGCCCGGGG
GCTGAGCGGCCGGGGCGTCCCACCGCCGGCAGCCACAGCTTCCTCCTCCGCCCGGGACCTCTGGCCGGAAGCAGTCCGTTCGCCTTACTA
GACCCGCTCCAAGCCTTTGAGCAGTTCGTGTGGGTCCGCTCCCAAGCTAGGGCTGGGCTGTTGCGCTTGCGCCAGGGGTCGCATGCAGTC
ACGCGCTGCCGACCGCTTCCGGTGCGCCGCGAGGGCCGCCGGGACGGGTCTCCCTGGCGATCCGTGGTGTGCCGCTACTGCCGGTGCAGC
CGCCAAACCGGTGCCTCGGTGACGACCGTGTCCCTGCCGTCTTCCTCGAGCTCCCCGGGGCTTGACCCCCGGGGCCCTCGGCAGGCATCG
GTGAGGAGCCTGCGGAGCGAACCTGTGCTCCTATTCTTGCCCTTCAGGACCCCATATCGCGACTCCGAGGAGGGGAAGCGAGAGGGGCTG
TCGCGACTCCGCGCCGTGTGTCGCCGGGCGGGGCCGCGGGGCCGGGGCTCCTTCAGCCCCCGGGATGCGCGCGCGAGCCCTCGCCTCCAC
TTCCTTGTTGCTGCTGTCACGACTGGAGCCGCCTCTCGCCGACAGCGGGGAGCGCGAGTGCGCCAGCCATCCCCCTCGTCCAGCCGCCGG
GCCAAGCGCCTCCGGGAATGTGAGCGGCGCAGCTTGCACGCTCCTCCGGCCATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTG
ATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTCCTGGGCCACCCAAGAAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAG
AAACCCAGGTCTGCTTACCTTCTGTACTATTACGACATCTACCTGAAAGTGCAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAAT
AAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGGCCGAGAGGAGTTACTACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGAT
CCTTCCGATACATACTTCTGCATGTCTATGCGAATACCAGTGGATGAGGAAGCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGAT
ACTGTCCATCACATGTTACTTTTTGGATGCAATATGCCTTCATCCACTGGAAGTTACTGGTTTTGTGATGAAGGAACCTGTACAGATAAA
GCCAATATTCTGTATGCCTGGGCGAGAAATGCTCCCCCTACCCGGCTCCCCAAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGT
AAATACTTTGTACTACAGGTACACTATGGGGATATTAGTGCTTTTAGAGATAATAACAAGGACTGTTCTGGTGTGTCCTTACACCTCACA
CGTCTGCCACAGCCTTTAATTGCTGGCATGTACCTTATGATGTCTGTTGACACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGAC
ATTTCATGCCATTATAAAAATTATCCAATGCATGTCTTTGCCTATAGAGTTCACACTCACCATTTAGGTAAGGTAGTAAGTGGATACAGA
GTAAGAAATGGACAGTGGACACTGATTGGACGGCAGAGCCCTCAGCTGCCACAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGT
TTTGGTGACCTACTGGCTGCAAGATGTGTATTCACTGGTGAAGGAAGGACAGAAGCCACACACATTGGTGGCACGTCTAGTGATGAAATG
TGCAACTTATACATTATGTATTACATGGAAGCCAAGCATGCAGTTTCTTTCATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGA
ACCATACCACCAGAGGCCAACATTCCAATTCCCGTGAAGTCTGATATGGTTATGATGCATGAACATCATAAAGAAACAGAATATAAAGAT
AAGATTCCTTTACTACAGCAGCCAAAACGAGAAGAAGAAGAAGTGTTAGACCAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGA
GAAAGGGAAGATGTTGTTCATGTGCACAAATATAATCCTACAGAAAAGGCAGAATCAGAGTCAGACCTGGTAGCTGAGATTGCAAATGTA
GTCCAAAAAAAGGATCTTGGTCGATCTGATGCCAGAGAGGGTGCAGAACATGAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCAC
AAATTCCACAGACTAGTATCTACCTTGAGGCCACCAGAGAGCAGAGTTTTCTCATTACAGCAGCCCCCACCTGGTGAAGGCACCTGGGAA
CCAGAACACACAGGAGATTTCCACATGGAAGAGGCACTGGATTGGCCTGGAGTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTA
GACCCTAAGAATAACCTGGTGATTTTCCACAGAGGTGACCATGTCTGGGATGGAAACTCGTTTGACAGCAAGTTTGTTTACCAGCAAATA
GGACTCGGACCAATTGAAGAAGACACTATTCTTGTCATAGATCCAAATAATGCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTTTTAC
TTGCCACATGGCTTGAGTATAGATAAAGATGGGAATTATTGGGTCACAGACGTGGCTCTCCATCAGGTGTTCAAACTGGATCCAAACAAT
AAAGAAGGCCCTGTATTAATCCTGGGAAGGAGCATGCAACCAGGCAGTGACCAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGAT
CCAGGCACTGGAGCCATTTATGTATCAGATGGTTACTGCAACAGCAGGATTGTGCAGTTTTCACCAAGTGGAAAGTTCATCACACAGTGG
GGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCAGGCCAGTTCACTGTTCCTCACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGT
GTGGCAGACCGGGAAAATGGTCGGATCCAGTGTTTTAAAACTGACACCAAAGAATTTGTGAGAGAGATTAAGCATTCATCATTTGGAAGA
AATGTATTTGCAATTTCATATATACCAGGCTTGCTCTTTGCAGTGAATGGGAAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTT
GTGATGAACTTTTCCAATGGGGAAATTATAGACATCTTCAAGCCAGTGCGCAAGCACTTTGATATGCCTCATGATATTGTTGCATCTGAA
GATGGGACTGTGTACATTGGAGATGCTCATACCAACACCGTGTGGAAGTTCACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAG
GCTGGCATTGAGGTCCAGGAAATCAAAGAAGCCGAGGCAGTTGTTGAAACCAAAATGGAGAACAAACCCACCTCCTCAGAATTGCAGAAG
ATGCAAGAGAAACAGAAACTGATCAAAGAGCCAGGCTCGGGAGTGCCTGTTGTTCTCATTACAACCCTTCTGGTTATTCCGGTGGTTGTC
CTGCTGGCCATTGCCATATTTATTCGGTGGAAAAAATCAAGGGCCTTTGGAGATTCTGAACACAAACTCGAGACGAGTTCAGGAAGAGTA
CTGGGAAGATTTAGAGGAAAGGGAAGTGGAGGCTTAAACCTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGAC
CGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGGATGATGGAAGTGAATCAGAAGAGGAGTATTCAGCACCTCTGCCTGCGCTCGCA
CCTTCCTCCTCCTGAAAACCAAGCTTTGATTTAGATTGAGTAAGATTTACCCAGAATGTCAGATTCCTTTCCCTTTAGCACGTTTAAAGT
TCTGTGTATTTAATTGTAAACTGTACTAGTCTGTGTGGGACTGTACACACTTTATTTACTTCGTTTTGGTTAAGTTGGCTTCTGTTTCTA
GTTGAGGAGTTTCCTAAAAGTTCATAACAGTGCCATTGTCTTTATATGAACATAGACTAGAGAAACCGTCCTCTTTTTCCATCATAATTC
TAATCTAACAATGGAAGATTTGCCCATTTACACTTTTGAGACTTTTTGGTGGATGTAAATAACCCCATTCTTTGCTTGAACACAGTATTT
TCCCAATAGCACTTTCATTGCCAGTGTCTTTCTTTGGTGCCTTTCCTGTTCAGCATTCTTAGCCTGTGGCAGTAAAGAGAAACTTTGTGC
TACATGACGACAAAGCTGCTAAATCTCCTATTTTTTTAAAATCACTAACATTATATTGCAATGAAGGAAATAAAAAAGTCTCTATTTAAA
TTCTTTTTTAAATTTTCTTCAGTTGGTGTGTTTTTGGGATGTCTTATTTTTAGATGGTTACACTGTTAGAACACTATTTTCAGAATCTGA
ATGTAATTTGTGTAATAAAGTGTTTTCAGAGCATTAGCTGTCAGTGTATTTTCCAGTTTTTGCGTATTTGCAGATTTTACATACAACTTT
TATAATAATTACACAAACCCACAAATATTAGTGAAACTTACTCGATGTCTTCAACTAAAAGAAATGTGTGTATTGTACAAAATTTAGAAG
ATACTTTAGCCAATATAAATTAAAAACCAGCCTGAGTTTACATAAATTTGTAAAGTCAGGCTCTTCTAAAATCCAAAGAGGGTTTTTGCC
TATATATCAATCAGAGGATAAATACTTTAATAAAAGGTAATCACAGCTAAGTGGATACCTGTGTCTCAAATTACATATGCAAATGATCCA
TCAGTAGGGATCACTAATAATAGTTTTCCTTTTAAAAAATAATTTCAGGGCAGGTACAGTGGCTCAAGCCTATACTTCCAGGACTTTGGG
AGGCCAAGCAGAAGGATTGTGGGAGGCCAAGCAGAAGGATTGTTTGAGCCCAGAAATTCAAGGCTGCAGTGAGCTATGATCAATCCACTG
TACTCCAGCCTAGGCTACAGAGTGAGATCCTTTCTCTAAAATAAAATACAATTTCCATGTATCCATAGGAATATATTCATCTTTTACAGT
GATTGCAGATTAGTTTTAAAACGTCTTTTTCGTAATTCGTCAATGCAAGTTAGTAAGAACCAGATAATTTTCCATTTTAAAATGATAGGA
ATCTAAAACTCTTTTTCAAAAATGCCAACCTGTTTTTCCGGCATCATAGTAGTTGGAATAATACAGATATAATTGACTAATCATAAAGTA
CATGAGAGTACAGAAGGGAAATTTGGAAACGGTAAGTCTGCTAGGGCATTACAATCCTGTCCTAGCACTCCACCTTTATTCTGCCAACCT
GGGTTAATTAAAGATGGTAGCCTGGAAAGTAATGAATGACATTGACTTCAGGCAATCTTTCCACTGATTATTCTTGGCTGAACTTCATTT
ATCGAGTCAGAGAATGCACTGCCTGAGAAATGTCCCAGAGGAGTGAATCCTAGGCCTGGCCACAGTAGAATCGCCTGGAGAATTTAAGAA
AAAAATTGTTGGGCACTCACTCTTTCCAGTGATCTTTATTTAGTTGGCTTACAATGGAATACAGGTATGGTTCATGTTTTTAAATTTGTC
CAGGTGTTTCTATTGTGCAGTCACAGTTGAAAACCATTGTCTTCGAGAATAGCTATTCTATCTTGCCAGTTACAATAAGTGGATAGCTAT
ATTTTCACATAAATTATAGTTTACAGATGTTTGGAGGGGGAAGACAGGATCTGAGGTGTTTTGATATGACTGTTAGCACCAAAATCTGAA

>36970_36970_4_HMGXB3-PAM_HMGXB3_chr5_149386210_ENST00000503427_PAM_chr5_102237060_ENST00000438793_length(amino acids)=1243AA_BP=340
MNAPQQCPGAERPGRPTAGSHSFLLRPGPLAGSSPFALLDPLQAFEQFVWVRSQARAGLLRLRQGSHAVTRCRPLPVRREGRRDGSPWRS
VVCRYCRCSRQTGASVTTVSLPSSSSSPGLDPRGPRQASVRSLRSEPVLLFLPFRTPYRDSEEGKREGLSRLRAVCRRAGPRGRGSFSPR
DARASPRLHFLVAAVTTGAASRRQRGARVRQPSPSSSRRAKRLRECERRSLHAPPAMDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKK
YKIHGEKTKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGLDPSDTYFCMSMRIPVDEEAFVI
DFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKD
CSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFY
PVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHE
HHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESESDLVAEIANVVQKKDLGRSDAREGAEHERGN
AILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSF
DSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHF
CQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVR
EIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTE
KLEHRSVKKAGIEVQEIKEAEAVVETKMENKPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HMGXB3-PAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePAMchr5:149386210chr5:102237060ENST00000304400125925_94270.0975.0RASSF9
TgenePAMchr5:149386210chr5:102237060ENST00000346918123925_94270.0888.0RASSF9
TgenePAMchr5:149386210chr5:102237060ENST00000348126124925_94270.0867.0RASSF9
TgenePAMchr5:149386210chr5:102237060ENST00000438793125925_94270.0974.0RASSF9
TgenePAMchr5:149386210chr5:102237060ENST00000455264124925_94270.0906.0RASSF9


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for HMGXB3-PAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for HMGXB3-PAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource