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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HMGXB3-PPARGC1B (FusionGDB2 ID:36971)

Fusion Gene Summary for HMGXB3-PPARGC1B

check button Fusion gene summary
Fusion gene informationFusion gene name: HMGXB3-PPARGC1B
Fusion gene ID: 36971
HgeneTgene
Gene symbol

HMGXB3

PPARGC1B

Gene ID

22993

133522

Gene nameHMG-box containing 3PPARG coactivator 1 beta
SynonymsHMGX3|SMFERRL1|PERC|PGC-1(beta)|PGC1B
Cytomap

5q32

5q32

Type of geneprotein-codingprotein-coding
DescriptionHMG domain-containing protein 3HMG box domain containing 3peroxisome proliferator-activated receptor gamma coactivator 1-betaPGC-1-related estrogen receptor alpha coactivatorPPAR-gamma coactivator 1-betaPPARGC-1-betaPPARgamma coactivator 1 betaperoxisome proliferator-activated receptor gamma, coactivator 1
Modification date2020031320200322
UniProtAcc

Q12766

.
Ensembl transtripts involved in fusion geneENST00000502717, ENST00000503427, 
ENST00000394320, ENST00000309241, 
ENST00000403750, ENST00000461780, 
ENST00000360453, 
Fusion gene scores* DoF score5 X 5 X 6=1508 X 7 X 7=392
# samples 79
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HMGXB3 [Title/Abstract] AND PPARGC1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHMGXB3(149412166)-PPARGC1B(149227021), # samples:3
Anticipated loss of major functional domain due to fusion event.HMGXB3-PPARGC1B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HMGXB3-PPARGC1B seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
HMGXB3-PPARGC1B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPARGC1B

GO:0006355

regulation of transcription, DNA-templated

23836911

TgenePPARGC1B

GO:0030520

intracellular estrogen receptor signaling pathway

11854298

TgenePPARGC1B

GO:0045944

positive regulation of transcription by RNA polymerase II

11854298


check buttonFusion gene breakpoints across HMGXB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPARGC1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-K4-A3WU-01BHMGXB3chr5

149412166

-PPARGC1Bchr5

149227021

+
ChimerDB4BLCATCGA-K4-A3WU-01BHMGXB3chr5

149412166

+PPARGC1Bchr5

149227021

+
ChimerDB4OVTCGA-13-1405-01AHMGXB3chr5

149386210

+PPARGC1Bchr5

149199996

+


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Fusion Gene ORF analysis for HMGXB3-PPARGC1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000502717ENST00000394320HMGXB3chr5

149412166

+PPARGC1Bchr5

149227021

+
5CDS-3UTRENST00000503427ENST00000394320HMGXB3chr5

149412166

+PPARGC1Bchr5

149227021

+
5CDS-intronENST00000502717ENST00000309241HMGXB3chr5

149412166

+PPARGC1Bchr5

149227021

+
5CDS-intronENST00000502717ENST00000309241HMGXB3chr5

149386210

+PPARGC1Bchr5

149199996

+
5CDS-intronENST00000502717ENST00000403750HMGXB3chr5

149412166

+PPARGC1Bchr5

149227021

+
5CDS-intronENST00000502717ENST00000403750HMGXB3chr5

149386210

+PPARGC1Bchr5

149199996

+
5CDS-intronENST00000502717ENST00000461780HMGXB3chr5

149412166

+PPARGC1Bchr5

149227021

+
5CDS-intronENST00000502717ENST00000461780HMGXB3chr5

149386210

+PPARGC1Bchr5

149199996

+
5CDS-intronENST00000503427ENST00000309241HMGXB3chr5

149412166

+PPARGC1Bchr5

149227021

+
5CDS-intronENST00000503427ENST00000309241HMGXB3chr5

149386210

+PPARGC1Bchr5

149199996

+
5CDS-intronENST00000503427ENST00000403750HMGXB3chr5

149412166

+PPARGC1Bchr5

149227021

+
5CDS-intronENST00000503427ENST00000403750HMGXB3chr5

149386210

+PPARGC1Bchr5

149199996

+
5CDS-intronENST00000503427ENST00000461780HMGXB3chr5

149412166

+PPARGC1Bchr5

149227021

+
5CDS-intronENST00000503427ENST00000461780HMGXB3chr5

149386210

+PPARGC1Bchr5

149199996

+
Frame-shiftENST00000502717ENST00000360453HMGXB3chr5

149412166

+PPARGC1Bchr5

149227021

+
Frame-shiftENST00000503427ENST00000360453HMGXB3chr5

149412166

+PPARGC1Bchr5

149227021

+
In-frameENST00000502717ENST00000360453HMGXB3chr5

149386210

+PPARGC1Bchr5

149199996

+
In-frameENST00000502717ENST00000394320HMGXB3chr5

149386210

+PPARGC1Bchr5

149199996

+
In-frameENST00000503427ENST00000360453HMGXB3chr5

149386210

+PPARGC1Bchr5

149199996

+
In-frameENST00000503427ENST00000394320HMGXB3chr5

149386210

+PPARGC1Bchr5

149199996

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000503427HMGXB3chr5149386210+ENST00000360453PPARGC1Bchr5149199996+4054117315340491298
ENST00000503427HMGXB3chr5149386210+ENST00000394320PPARGC1Bchr5149199996+5856117315341481331
ENST00000502717HMGXB3chr5149386210+ENST00000360453PPARGC1Bchr5149199996+36577768636521188
ENST00000502717HMGXB3chr5149386210+ENST00000394320PPARGC1Bchr5149199996+54597768637511221

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000503427ENST00000360453HMGXB3chr5149386210+PPARGC1Bchr5149199996+0.0107575640.9892425
ENST00000503427ENST00000394320HMGXB3chr5149386210+PPARGC1Bchr5149199996+0.0076603050.99233973
ENST00000502717ENST00000360453HMGXB3chr5149386210+PPARGC1Bchr5149199996+0.0079967020.9920033
ENST00000502717ENST00000394320HMGXB3chr5149386210+PPARGC1Bchr5149199996+0.0051946240.9948054

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Fusion Genomic Features for HMGXB3-PPARGC1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HMGXB3chr5149412166+PPARGC1Bchr5149227020+0.909162940.09083708
HMGXB3chr5149386210+PPARGC1Bchr5149199995+4.37E-050.99995625
HMGXB3chr5149412166+PPARGC1Bchr5149227020+0.909162940.09083708
HMGXB3chr5149386210+PPARGC1Bchr5149199995+4.37E-050.99995625

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HMGXB3-PPARGC1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:149412166/chr5:149227021)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HMGXB3

Q12766

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000309241012430_450261024.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000309241012772_823261024.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000360453011430_45026985.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000360453011772_82326985.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000394320011430_450261018.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000394320011772_823261018.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000403750011430_4501960.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000403750011772_8231960.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000309241012902_976261024.0DomainRRM
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000360453011902_97626985.0DomainRRM
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000394320011902_976261018.0DomainRRM
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000403750011902_9761960.0DomainRRM
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000309241012156_160261024.0MotifNote=LXXLL motif 1
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000309241012691_694261024.0MotifNote=HCFC1-binding-motif (HBM)
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000360453011156_16026985.0MotifNote=LXXLL motif 1
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000360453011691_69426985.0MotifNote=HCFC1-binding-motif (HBM)
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000394320011156_160261018.0MotifNote=LXXLL motif 1
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000394320011691_694261018.0MotifNote=HCFC1-binding-motif (HBM)
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000403750011156_1601960.0MotifNote=LXXLL motif 1
TgenePPARGC1Bchr5:149386210chr5:149199996ENST00000403750011691_6941960.0MotifNote=HCFC1-binding-motif (HBM)
TgenePPARGC1Bchr5:149386210chr5:149199996ENST000004037500111_911960.0RegionNote=Abolishes DNA transcriptional activity when missing

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHMGXB3chr5:149386210chr5:149199996ENST00000502717+3201523_15321041293.0Compositional biasNote=Poly-Glu
HgeneHMGXB3chr5:149386210chr5:149199996ENST00000502717+320276_2821041293.0Compositional biasNote=Poly-Lys
HgeneHMGXB3chr5:149386210chr5:149199996ENST00000502717+320518_5241041293.0Compositional biasNote=Poly-Ser
HgeneHMGXB3chr5:149386210chr5:149199996ENST00000502717+32062_2391041293.0Compositional biasNote=Arg-rich
HgeneHMGXB3chr5:149386210chr5:149199996ENST00000502717+320288_3561041293.0DNA bindingHMG box
TgenePPARGC1Bchr5:149386210chr5:149199996ENST000003092410121_91261024.0RegionNote=Abolishes DNA transcriptional activity when missing
TgenePPARGC1Bchr5:149386210chr5:149199996ENST000003604530111_9126985.0RegionNote=Abolishes DNA transcriptional activity when missing
TgenePPARGC1Bchr5:149386210chr5:149199996ENST000003943200111_91261018.0RegionNote=Abolishes DNA transcriptional activity when missing


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Fusion Gene Sequence for HMGXB3-PPARGC1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36971_36971_1_HMGXB3-PPARGC1B_HMGXB3_chr5_149386210_ENST00000502717_PPARGC1B_chr5_149199996_ENST00000360453_length(transcript)=3657nt_BP=776nt
GCCGGGACGGGTCTCCCTGGCGATCCGTGGTGTGCCGCTACTGCCGGTGCAGCCGCCAAACCGGTGCCTCGGTGACGACCGTGTCCCTGC
CGTCTTCCTCGAGCTCCCCGGGGCTTGACCCCCGGGGCCCTCGGCAGGCATCGGTGAGGAGCCTGCGGAGCGAACCTGTGCTCCTATTCT
TGCCCTTCAGGACCCCATATCGCGACTCCGAGGAGGGGAAGCGAGAGGGGCTGTCGCGACTCCGCGCCGTGTGTCGCCGGGCGGGGCCGC
GGGGCCGGGGCTCCTTCAGCCCCCGGGATGCGCGCGCGAGCCCTCGCCTCCACTTCCTTGTTGCTGCTGTCACGACTGGAGCCGCCTCTC
GCCGACAGCGGGGAGCGCGAGTGCGCCAGCCATCCCCCTCGTCCAGCCGCCGGGCCAAGCGCCTCCGGGAATGTGAGCGGCGCAGCTTGC
ACGCTCCTCCGGCCATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTGATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTC
CTGGGCCACCCAAGAAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAGAAACCCAGGTCTGCTTACCTTCTGTACTATTACGACA
TCTACCTGAAAGTGCAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAATAAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGG
CCGAGAGGAGTTACTACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGATCCTGGTGGAGGGTCCGGGGAGGAGCAACTCTATGCTG
ACTTTCCAGAACTTGACCTCTCCCAGCTGGATGCCAGCGACTTTGACTCGGCCACCTGCTTTGGGGAGCTGCAGTGGTGCCCAGAGAACT
CAGAGACTGAACCCAACCAGTACAGCCCCGATGACTCCGAGCTCTTCCAGATTGACAGTGAGAATGAGGCCCTCCTGGCAGAGCTCACCA
AGACCCTGGATGACATCCCTGAAGATGACGTGGGTCTGGCTGCCTTCCCAGCCCTGGATGGTGGAGACGCTCTATCATGCACCTCAGCTT
CGCCTGCCCCCTCATCTGCACCCCCCAGCCCTGCCCCGGAGAAGCCCTCGGCCCCAGCCCCTGAGGTGGACGAGCTCTCACTGGCGGACA
GCACCCAAGACAAGAAGGCTCCCATGATGCAGTCTCAGAGCCGAAGTTGTACAGAACTACATAAGCACCTCACCTCGGCACAGTGCTGCC
TGCAGGATCGGGGTCTGCAGCCACCATGCCTCCAGAGTCCCCGGCTCCCTGCCAAGGAGGACAAGGAGCCGGGTGAGGACTGCCCGAGCC
CCCAGCCAGCTCCAGCCTCTCCCCGGGACTCCCTAGCTCTGGGCAGGGCAGACCCCGGTGCCCCGGTTTCCCAGGAAGACATGCAGGCGA
TGGTGCAACTCATACGCTACATGCACACCTACTGCCTCCCCCAGAGGAAGCTGCCCCCACAGACCCCTGAGCCACTCCCCAAGGCCTGCA
GCAACCCCTCCCAGCAGGTCAGATCCCGGCCCTGGTCCCGGCACCACTCCAAAGCCTCCTGGGCTGAGTTCTCCATTCTGAGGGAACTTC
TGGCTCAAGACGTGCTCTGTGATGTCAGCAAACCCTACCGTCTGGCCACGCCTGTTTATGCCTCCCTCACACCTCGGTCAAGGCCCAGGC
CCCCCAAAGACAGTCAGGCCTCCCCTGGTCGCCCGTCCTCGGTGGAGGAGGTAAGGATCGCAGCTTCACCCAAGAGCACCGGGCCCAGAC
CAAGCCTGCGCCCACTGCGGCTGGAGGTGAAAAGGGAGGTCCGCCGGCCTGCCAGACTGCAGCAGCAGGAGGAGGAAGACGAGGAAGAAG
AGGAGGAGGAAGAGGAAGAAGAAAAAGAGGAGGAGGAGGAGTGGGGCAGGAAAAGGCCAGGCCGAGGCCTGCCATGGACGAAGCTGGGGA
GGAAGCTGGAGAGCTCTGTGTGCCCCGTGCGGCGTTCTCGGAGACTGAACCCTGAGCTGGGCCCCTGGCTGACATTTGCAGATGAGCCGC
TGGTCCCCTCGGAGCCCCAAGGTGCTCTGCCCTCACTGTGCCTGGCTCCCAAGGCCTACGACGTAGAGCGGGAGCTGGGCAGCCCCACGG
ACGAGGACAGTGGCCAAGACCAGCAGCTCCTACGGGGACCCCAGATCCCTGCCCTGGAGAGCCCCTGTGAGAGTGGGTGTGGGGACATGG
ATGAGGACCCCAGCTGCCCGCAGCTCCCTCCCAGAGACTCTCCCAGGTGCCTCATGCTGGCCTTGTCACAAAGCGACCCAACTTTTGGCA
AGAAGAGCTTTGAGCAGACCTTGACAGTGGAGCTCTGTGGCACAGCAGGACTCACCCCACCCACCACACCACCGTACAAGCCCACAGAGG
AGGATCCCTTCAAACCAGACATCAAGCATAGTCTAGGCAAAGAAATAGCTCTCAGCCTCCCCTCCCCTGAGGGCCTCTCACTCAAGGCCA
CCCCAGGGGCTGCCCACAAGCTGCCAAAGAAGCACCCAGAGCGAAGTGAGCTCCTGTCCCACCTGCGACATGCCACAGCCCAGCCAGCCT
CCCAGGCTGGCCAGAAGCGTCCCTTCTCCTGTTCCTTTGGAGACCATGACTACTGCCAGGTGCTCCGACCAGAAGGCGTCCTGCAAAGGA
AGGTGCTGAGGTCCTGGGAGCCGTCTGGGGTTCACCTTGAGGACTGGCCCCAGCAGGGTGCCCCTTGGGCTGAGGCACAGGCCCCTGGCA
GGGAGGAAGACAGAAGCTGTGATGCTGGCGCCCCACCCAAGGACAGCACGCTGCTGAGAGACCATGAGATCCGTGCCAGCCTCACCAAAC
ACTTTGGGCTGCTGGAGACCGCCCTGGAGGAGGAAGACCTGGCCTCCTGCAAGAGCCCTGAGTATGACACTGTCTTTGAAGACAGCAGCA
GCAGCAGCGGCGAGAGCAGCTTCCTCCCAGAGGAGGAAGAGGAAGAAGGGGAGGAGGAGGAGGAGGACGATGAAGAAGAGGACTCAGGGG
TCAGCCCCACTTGCTCTGACCACTGCCCCTACCAGAGCCCACCAAGCAAGGCCAACCGGCAGCTCTGTTCCCGCAGCCGCTCAAGCTCTG
GCTCTTCACCCTGCCACTCCTGGTCACCAGCCACTCGAAGGAACTTCAGATGTGAGAGCAGAGGGCCGTGTTCAGACAGAACGCCAAGCA
TCCGGCACGCCAGGAAGCGGCGGGAAAAGGCCATTGGGGAAGGCCGCGTGGTGTACATTCAAAATCTCTCCAGCGACATGAGCTCCCGAG
AGCTGAAGAGGCGCTTTGAAGTGTTTGGTGAGATTGAGGAGTGCGAGGTGCTGACAAGAAATAGGAGAGGCGAGAAGTACGGCTTCATCA
CCTACCGGTGTTCTGAGCACGCGGCCCTCTCTTTGACAAAGGGCGCTGCCCTGAGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGCTACG
GAGGGCTCCGGCACTTCTGCTGGCCCAGATACACTGACTACGATTCCAATTCAGAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAGTATG

>36971_36971_1_HMGXB3-PPARGC1B_HMGXB3_chr5_149386210_ENST00000502717_PPARGC1B_chr5_149199996_ENST00000360453_length(amino acids)=1188AA_BP=230
MPSSSSSPGLDPRGPRQASVRSLRSEPVLLFLPFRTPYRDSEEGKREGLSRLRAVCRRAGPRGRGSFSPRDARASPRLHFLVAAVTTGAA
SRRQRGARVRQPSPSSSRRAKRLRECERRSLHAPPAMDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKKPRSAYLLYYY
DIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGLDPGGGSGEEQLYADFPELDLSQLDASDFDSATCFGELQWCPE
NSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLA
DSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASPRDSLALGRADPGAPVSQEDMQ
AMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRP
RPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKL
GRKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGD
MDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLK
ATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAP
GREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDS
GVSPTCSDHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGEGRVVYIQNLSSDMSS
RELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSK

--------------------------------------------------------------
>36971_36971_2_HMGXB3-PPARGC1B_HMGXB3_chr5_149386210_ENST00000502717_PPARGC1B_chr5_149199996_ENST00000394320_length(transcript)=5459nt_BP=776nt
GCCGGGACGGGTCTCCCTGGCGATCCGTGGTGTGCCGCTACTGCCGGTGCAGCCGCCAAACCGGTGCCTCGGTGACGACCGTGTCCCTGC
CGTCTTCCTCGAGCTCCCCGGGGCTTGACCCCCGGGGCCCTCGGCAGGCATCGGTGAGGAGCCTGCGGAGCGAACCTGTGCTCCTATTCT
TGCCCTTCAGGACCCCATATCGCGACTCCGAGGAGGGGAAGCGAGAGGGGCTGTCGCGACTCCGCGCCGTGTGTCGCCGGGCGGGGCCGC
GGGGCCGGGGCTCCTTCAGCCCCCGGGATGCGCGCGCGAGCCCTCGCCTCCACTTCCTTGTTGCTGCTGTCACGACTGGAGCCGCCTCTC
GCCGACAGCGGGGAGCGCGAGTGCGCCAGCCATCCCCCTCGTCCAGCCGCCGGGCCAAGCGCCTCCGGGAATGTGAGCGGCGCAGCTTGC
ACGCTCCTCCGGCCATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTGATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTC
CTGGGCCACCCAAGAAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAGAAACCCAGGTCTGCTTACCTTCTGTACTATTACGACA
TCTACCTGAAAGTGCAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAATAAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGG
CCGAGAGGAGTTACTACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGATCCTGGTGGAGGGTCCGGGGAGGAGCAACTCTATGCTG
ACTTTCCAGAACTTGACCTCTCCCAGCTGGATGCCAGCGACTTTGACTCGGCCACCTGCTTTGGGGAGCTGCAGTGGTGCCCAGAGAACT
CAGAGACTGAACCCAACCAGTACAGCCCCGATGACTCCGAGCTCTTCCAGATTGACAGTGAGAATGAGGCCCTCCTGGCAGAGCTCACCA
AGACCCTGGATGACATCCCTGAAGATGACGTGGGTCTGGCTGCCTTCCCAGCCCTGGATGGTGGAGACGCTCTATCATGCACCTCAGCTT
CGCCTGCCCCCTCATCTGCACCCCCCAGCCCTGCCCCGGAGAAGCCCTCGGCCCCAGCCCCTGAGGTGGACGAGCTCTCACTGCTGCAGA
AGCTCCTCCTGGCCACATCCTACCCAACATCAAGCTCTGACACCCAGAAGGAAGGGACCGCCTGGCGCCAGGCAGGCCTCAGATCTAAAA
GTCAACGGCCTTGTGTTAAGGCGGACAGCACCCAAGACAAGAAGGCTCCCATGATGCAGTCTCAGAGCCGAAGTTGTACAGAACTACATA
AGCACCTCACCTCGGCACAGTGCTGCCTGCAGGATCGGGGTCTGCAGCCACCATGCCTCCAGAGTCCCCGGCTCCCTGCCAAGGAGGACA
AGGAGCCGGGTGAGGACTGCCCGAGCCCCCAGCCAGCTCCAGCCTCTCCCCGGGACTCCCTAGCTCTGGGCAGGGCAGACCCCGGTGCCC
CGGTTTCCCAGGAAGACATGCAGGCGATGGTGCAACTCATACGCTACATGCACACCTACTGCCTCCCCCAGAGGAAGCTGCCCCCACAGA
CCCCTGAGCCACTCCCCAAGGCCTGCAGCAACCCCTCCCAGCAGGTCAGATCCCGGCCCTGGTCCCGGCACCACTCCAAAGCCTCCTGGG
CTGAGTTCTCCATTCTGAGGGAACTTCTGGCTCAAGACGTGCTCTGTGATGTCAGCAAACCCTACCGTCTGGCCACGCCTGTTTATGCCT
CCCTCACACCTCGGTCAAGGCCCAGGCCCCCCAAAGACAGTCAGGCCTCCCCTGGTCGCCCGTCCTCGGTGGAGGAGGTAAGGATCGCAG
CTTCACCCAAGAGCACCGGGCCCAGACCAAGCCTGCGCCCACTGCGGCTGGAGGTGAAAAGGGAGGTCCGCCGGCCTGCCAGACTGCAGC
AGCAGGAGGAGGAAGACGAGGAAGAAGAGGAGGAGGAAGAGGAAGAAGAAAAAGAGGAGGAGGAGGAGTGGGGCAGGAAAAGGCCAGGCC
GAGGCCTGCCATGGACGAAGCTGGGGAGGAAGCTGGAGAGCTCTGTGTGCCCCGTGCGGCGTTCTCGGAGACTGAACCCTGAGCTGGGCC
CCTGGCTGACATTTGCAGATGAGCCGCTGGTCCCCTCGGAGCCCCAAGGTGCTCTGCCCTCACTGTGCCTGGCTCCCAAGGCCTACGACG
TAGAGCGGGAGCTGGGCAGCCCCACGGACGAGGACAGTGGCCAAGACCAGCAGCTCCTACGGGGACCCCAGATCCCTGCCCTGGAGAGCC
CCTGTGAGAGTGGGTGTGGGGACATGGATGAGGACCCCAGCTGCCCGCAGCTCCCTCCCAGAGACTCTCCCAGGTGCCTCATGCTGGCCT
TGTCACAAAGCGACCCAACTTTTGGCAAGAAGAGCTTTGAGCAGACCTTGACAGTGGAGCTCTGTGGCACAGCAGGACTCACCCCACCCA
CCACACCACCGTACAAGCCCACAGAGGAGGATCCCTTCAAACCAGACATCAAGCATAGTCTAGGCAAAGAAATAGCTCTCAGCCTCCCCT
CCCCTGAGGGCCTCTCACTCAAGGCCACCCCAGGGGCTGCCCACAAGCTGCCAAAGAAGCACCCAGAGCGAAGTGAGCTCCTGTCCCACC
TGCGACATGCCACAGCCCAGCCAGCCTCCCAGGCTGGCCAGAAGCGTCCCTTCTCCTGTTCCTTTGGAGACCATGACTACTGCCAGGTGC
TCCGACCAGAAGGCGTCCTGCAAAGGAAGGTGCTGAGGTCCTGGGAGCCGTCTGGGGTTCACCTTGAGGACTGGCCCCAGCAGGGTGCCC
CTTGGGCTGAGGCACAGGCCCCTGGCAGGGAGGAAGACAGAAGCTGTGATGCTGGCGCCCCACCCAAGGACAGCACGCTGCTGAGAGACC
ATGAGATCCGTGCCAGCCTCACCAAACACTTTGGGCTGCTGGAGACCGCCCTGGAGGAGGAAGACCTGGCCTCCTGCAAGAGCCCTGAGT
ATGACACTGTCTTTGAAGACAGCAGCAGCAGCAGCGGCGAGAGCAGCTTCCTCCCAGAGGAGGAAGAGGAAGAAGGGGAGGAGGAGGAGG
AGGACGATGAAGAAGAGGACTCAGGGGTCAGCCCCACTTGCTCTGACCACTGCCCCTACCAGAGCCCACCAAGCAAGGCCAACCGGCAGC
TCTGTTCCCGCAGCCGCTCAAGCTCTGGCTCTTCACCCTGCCACTCCTGGTCACCAGCCACTCGAAGGAACTTCAGATGTGAGAGCAGAG
GGCCGTGTTCAGACAGAACGCCAAGCATCCGGCACGCCAGGAAGCGGCGGGAAAAGGCCATTGGGGAAGGCCGCGTGGTGTACATTCAAA
ATCTCTCCAGCGACATGAGCTCCCGAGAGCTGAAGAGGCGCTTTGAAGTGTTTGGTGAGATTGAGGAGTGCGAGGTGCTGACAAGAAATA
GGAGAGGCGAGAAGTACGGCTTCATCACCTACCGGTGTTCTGAGCACGCGGCCCTCTCTTTGACAAAGGGCGCTGCCCTGAGGAAGCGCA
ACGAGCCCTCCTTCCAGCTGAGCTACGGAGGGCTCCGGCACTTCTGCTGGCCCAGATACACTGACTACGGTAAGCCCCTGAAACCCAGCC
ACAGTCTAGTAAGACTCAAAGCTTGGGAAGCAGTGCCTTCCTTGAACAAAACCCAGAGCTAAAGCGCCTTGTGGACATAGCTTCCATCCC
CACACCCCAGTGTGCTGCTTGGTATAACTTTGCAGCCACTTTGCCTGAAGACTACCATCCTGTTTCTCTTCTGGCCTCTGGTCCACCTTA
TCCTGTCCTGTGACTGCTACCAAAGAGAATCCAGCCTCCCACGGCCTCTAGGAAGATTCAGTCATGTGCACAGCCAGCTGGCAGAACCGT
GGCTACGGTCTCCTTGACTTCACAGGGCCAGCTGCTACCCTGTCCCCTTCAGGGGCATTCCGTGGTGACCCCAGACAAGGCAGCAGCCAC
CTGGGGACAAGATGATGAAGAAGGACAAAGAAGTACAATGTACGAAAGAATTACTTGGCCAGGCTCAGTGGCTCATGCCTGTAATCCCAT
CACCTTGGGAGGCTGAGGCAAGAGGATCACTTGAGCCCAGGAGTTCGAGACCAGCTTGGGCAACATAGTGAAATCCTGTCTCTACAAAAA
ATATAAAAATTAGCCAGGCATGGTGGCTTGCGCCTATAGTCCCAGCTACTCAGGAGGCAGAGGTGGGAGGATCACCTGAACCCAAGAGGT
TGGAGCTGCAGTGAGCCATGATGGCACTACTGCATTCCAGCCTGGGCAACAGAGCAAGACCCTGTCTCAAAAGGAAAGAAAAAAAAAAAA
ACACTTACTGGAGAGAATCCAATGCAGCCTTGATGGTACAGGACTGAGTGTCAGTGACCCGGCTGGGTGCCAGGCCAGGCGGCCCTGCCC
TTGGCTGCATGTCCATTTATGGGAATCAGTTTCCCAATCTATTAAAAAATTCTAGTGTTGGCTGGGTGCAGTTGCTCACGCCTGTAATCC
CAGCACTTTGGGAGGCCGAGGCAGGAAGATCATGAGGTCAAGAGATCGAGACCATCGTGGCCAACATGGTGAAACCCCCTCTCTATTAAA
AATACAAAAATTAGCTGGGCGTGGTGGCGCACACCTGTAGTCCCAGCAACTTGGGAGGCTGAGGCGGGAGAATCACTTGAACCCGAGAGG
CAGAGGTTGCAGTGAGCTGAGATCACATCCCTGCACTCCAGCCTTGGTGACAGAGCGAGACTGCATCTCAAAAAAAAAAAAATTCTAGTG
TTGTTAGCCCTCCCTTATGTGGCACTGCAGCAGGTTACTAATGGACGAGAAGCTGTTGGGGGAAGTAGAGTTGTAGGGTGTTGGAGCTAG
AAAGGCTCTGGAGTGCTCTAGTTTGGGCCTCCAGGTCTCTAGATAGGACAGCCAAGGCCCTGAGACACTGATACCATGGCCAAGATGTCC
CAGCAGGATGGCAGGCAGTGCCCACAGTCCAGCGCTCATCCCAGCTCCCCAAGGCCTTGGGCTGCAGCCACTCCACGGTGCCCACTCATA
GTGGCAGATTCTTCAACCATCCGGTCTTTGTAAGTTGCTCACTGCCTTCCCCTCTTCCCTGCCTCTTCACCCCCATGCCCAGATTCCAAT
TCAGAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAGTATGAAGCCATGGATTTTGACAGCTTACTGAAAGAGGCCCAGCAGAGCCTGCAT
TGATAACAGCCTTAACCCTCGAGGAATACCTCAATACCTCAGACAAGGCCCTTCCAATATGTTTACGTTTTCAAAGAAATCAAGTATATG

>36971_36971_2_HMGXB3-PPARGC1B_HMGXB3_chr5_149386210_ENST00000502717_PPARGC1B_chr5_149199996_ENST00000394320_length(amino acids)=1221AA_BP=230
MPSSSSSPGLDPRGPRQASVRSLRSEPVLLFLPFRTPYRDSEEGKREGLSRLRAVCRRAGPRGRGSFSPRDARASPRLHFLVAAVTTGAA
SRRQRGARVRQPSPSSSRRAKRLRECERRSLHAPPAMDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKKPRSAYLLYYY
DIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGLDPGGGSGEEQLYADFPELDLSQLDASDFDSATCFGELQWCPE
NSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLL
QKLLLATSYPTSSSDTQKEGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLPAKE
DKEPGEDCPSPQPAPASPRDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKAS
WAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARL
QQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAY
DVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLTP
PTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQ
VLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSP
EYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCES
RGPCSDRTPSIRHARKRREKAIGEGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRK

--------------------------------------------------------------
>36971_36971_3_HMGXB3-PPARGC1B_HMGXB3_chr5_149386210_ENST00000503427_PPARGC1B_chr5_149199996_ENST00000360453_length(transcript)=4054nt_BP=1173nt
ATGAGAGGGAAAGACTGAGACAGGCTGAGGTCAGGCCTTGAACGTCGTGCTGAGGAGAGGGTGGTATTGTAGGCTTCCCAGCGCCCGACG
TGGCTCTGAAAGGTGAGGCGGGGCCTAGATCCCTCACGCTCAGCACAGCCCCGCCCCTGTTACCTGAACGCCCCACAGCAGTGCCCGGGG
GCTGAGCGGCCGGGGCGTCCCACCGCCGGCAGCCACAGCTTCCTCCTCCGCCCGGGACCTCTGGCCGGAAGCAGTCCGTTCGCCTTACTA
GACCCGCTCCAAGCCTTTGAGCAGTTCGTGTGGGTCCGCTCCCAAGCTAGGGCTGGGCTGTTGCGCTTGCGCCAGGGGTCGCATGCAGTC
ACGCGCTGCCGACCGCTTCCGGTGCGCCGCGAGGGCCGCCGGGACGGGTCTCCCTGGCGATCCGTGGTGTGCCGCTACTGCCGGTGCAGC
CGCCAAACCGGTGCCTCGGTGACGACCGTGTCCCTGCCGTCTTCCTCGAGCTCCCCGGGGCTTGACCCCCGGGGCCCTCGGCAGGCATCG
GTGAGGAGCCTGCGGAGCGAACCTGTGCTCCTATTCTTGCCCTTCAGGACCCCATATCGCGACTCCGAGGAGGGGAAGCGAGAGGGGCTG
TCGCGACTCCGCGCCGTGTGTCGCCGGGCGGGGCCGCGGGGCCGGGGCTCCTTCAGCCCCCGGGATGCGCGCGCGAGCCCTCGCCTCCAC
TTCCTTGTTGCTGCTGTCACGACTGGAGCCGCCTCTCGCCGACAGCGGGGAGCGCGAGTGCGCCAGCCATCCCCCTCGTCCAGCCGCCGG
GCCAAGCGCCTCCGGGAATGTGAGCGGCGCAGCTTGCACGCTCCTCCGGCCATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTG
ATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTCCTGGGCCACCCAAGAAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAG
AAACCCAGGTCTGCTTACCTTCTGTACTATTACGACATCTACCTGAAAGTGCAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAAT
AAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGGCCGAGAGGAGTTACTACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGAT
CCTGGTGGAGGGTCCGGGGAGGAGCAACTCTATGCTGACTTTCCAGAACTTGACCTCTCCCAGCTGGATGCCAGCGACTTTGACTCGGCC
ACCTGCTTTGGGGAGCTGCAGTGGTGCCCAGAGAACTCAGAGACTGAACCCAACCAGTACAGCCCCGATGACTCCGAGCTCTTCCAGATT
GACAGTGAGAATGAGGCCCTCCTGGCAGAGCTCACCAAGACCCTGGATGACATCCCTGAAGATGACGTGGGTCTGGCTGCCTTCCCAGCC
CTGGATGGTGGAGACGCTCTATCATGCACCTCAGCTTCGCCTGCCCCCTCATCTGCACCCCCCAGCCCTGCCCCGGAGAAGCCCTCGGCC
CCAGCCCCTGAGGTGGACGAGCTCTCACTGGCGGACAGCACCCAAGACAAGAAGGCTCCCATGATGCAGTCTCAGAGCCGAAGTTGTACA
GAACTACATAAGCACCTCACCTCGGCACAGTGCTGCCTGCAGGATCGGGGTCTGCAGCCACCATGCCTCCAGAGTCCCCGGCTCCCTGCC
AAGGAGGACAAGGAGCCGGGTGAGGACTGCCCGAGCCCCCAGCCAGCTCCAGCCTCTCCCCGGGACTCCCTAGCTCTGGGCAGGGCAGAC
CCCGGTGCCCCGGTTTCCCAGGAAGACATGCAGGCGATGGTGCAACTCATACGCTACATGCACACCTACTGCCTCCCCCAGAGGAAGCTG
CCCCCACAGACCCCTGAGCCACTCCCCAAGGCCTGCAGCAACCCCTCCCAGCAGGTCAGATCCCGGCCCTGGTCCCGGCACCACTCCAAA
GCCTCCTGGGCTGAGTTCTCCATTCTGAGGGAACTTCTGGCTCAAGACGTGCTCTGTGATGTCAGCAAACCCTACCGTCTGGCCACGCCT
GTTTATGCCTCCCTCACACCTCGGTCAAGGCCCAGGCCCCCCAAAGACAGTCAGGCCTCCCCTGGTCGCCCGTCCTCGGTGGAGGAGGTA
AGGATCGCAGCTTCACCCAAGAGCACCGGGCCCAGACCAAGCCTGCGCCCACTGCGGCTGGAGGTGAAAAGGGAGGTCCGCCGGCCTGCC
AGACTGCAGCAGCAGGAGGAGGAAGACGAGGAAGAAGAGGAGGAGGAAGAGGAAGAAGAAAAAGAGGAGGAGGAGGAGTGGGGCAGGAAA
AGGCCAGGCCGAGGCCTGCCATGGACGAAGCTGGGGAGGAAGCTGGAGAGCTCTGTGTGCCCCGTGCGGCGTTCTCGGAGACTGAACCCT
GAGCTGGGCCCCTGGCTGACATTTGCAGATGAGCCGCTGGTCCCCTCGGAGCCCCAAGGTGCTCTGCCCTCACTGTGCCTGGCTCCCAAG
GCCTACGACGTAGAGCGGGAGCTGGGCAGCCCCACGGACGAGGACAGTGGCCAAGACCAGCAGCTCCTACGGGGACCCCAGATCCCTGCC
CTGGAGAGCCCCTGTGAGAGTGGGTGTGGGGACATGGATGAGGACCCCAGCTGCCCGCAGCTCCCTCCCAGAGACTCTCCCAGGTGCCTC
ATGCTGGCCTTGTCACAAAGCGACCCAACTTTTGGCAAGAAGAGCTTTGAGCAGACCTTGACAGTGGAGCTCTGTGGCACAGCAGGACTC
ACCCCACCCACCACACCACCGTACAAGCCCACAGAGGAGGATCCCTTCAAACCAGACATCAAGCATAGTCTAGGCAAAGAAATAGCTCTC
AGCCTCCCCTCCCCTGAGGGCCTCTCACTCAAGGCCACCCCAGGGGCTGCCCACAAGCTGCCAAAGAAGCACCCAGAGCGAAGTGAGCTC
CTGTCCCACCTGCGACATGCCACAGCCCAGCCAGCCTCCCAGGCTGGCCAGAAGCGTCCCTTCTCCTGTTCCTTTGGAGACCATGACTAC
TGCCAGGTGCTCCGACCAGAAGGCGTCCTGCAAAGGAAGGTGCTGAGGTCCTGGGAGCCGTCTGGGGTTCACCTTGAGGACTGGCCCCAG
CAGGGTGCCCCTTGGGCTGAGGCACAGGCCCCTGGCAGGGAGGAAGACAGAAGCTGTGATGCTGGCGCCCCACCCAAGGACAGCACGCTG
CTGAGAGACCATGAGATCCGTGCCAGCCTCACCAAACACTTTGGGCTGCTGGAGACCGCCCTGGAGGAGGAAGACCTGGCCTCCTGCAAG
AGCCCTGAGTATGACACTGTCTTTGAAGACAGCAGCAGCAGCAGCGGCGAGAGCAGCTTCCTCCCAGAGGAGGAAGAGGAAGAAGGGGAG
GAGGAGGAGGAGGACGATGAAGAAGAGGACTCAGGGGTCAGCCCCACTTGCTCTGACCACTGCCCCTACCAGAGCCCACCAAGCAAGGCC
AACCGGCAGCTCTGTTCCCGCAGCCGCTCAAGCTCTGGCTCTTCACCCTGCCACTCCTGGTCACCAGCCACTCGAAGGAACTTCAGATGT
GAGAGCAGAGGGCCGTGTTCAGACAGAACGCCAAGCATCCGGCACGCCAGGAAGCGGCGGGAAAAGGCCATTGGGGAAGGCCGCGTGGTG
TACATTCAAAATCTCTCCAGCGACATGAGCTCCCGAGAGCTGAAGAGGCGCTTTGAAGTGTTTGGTGAGATTGAGGAGTGCGAGGTGCTG
ACAAGAAATAGGAGAGGCGAGAAGTACGGCTTCATCACCTACCGGTGTTCTGAGCACGCGGCCCTCTCTTTGACAAAGGGCGCTGCCCTG
AGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGCTACGGAGGGCTCCGGCACTTCTGCTGGCCCAGATACACTGACTACGATTCCAATTCA
GAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAGTATGAAGCCATGGATTTTGACAGCTTACTGAAAGAGGCCCAGCAGAGCCTGCATTGA

>36971_36971_3_HMGXB3-PPARGC1B_HMGXB3_chr5_149386210_ENST00000503427_PPARGC1B_chr5_149199996_ENST00000360453_length(amino acids)=1298AA_BP=340
MNAPQQCPGAERPGRPTAGSHSFLLRPGPLAGSSPFALLDPLQAFEQFVWVRSQARAGLLRLRQGSHAVTRCRPLPVRREGRRDGSPWRS
VVCRYCRCSRQTGASVTTVSLPSSSSSPGLDPRGPRQASVRSLRSEPVLLFLPFRTPYRDSEEGKREGLSRLRAVCRRAGPRGRGSFSPR
DARASPRLHFLVAAVTTGAASRRQRGARVRQPSPSSSRRAKRLRECERRSLHAPPAMDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKK
YKIHGEKTKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGLDPGGGSGEEQLYADFPELDLSQ
LDASDFDSATCFGELQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASPAPSSAPP
SPAPEKPSAPAPEVDELSLADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASPR
DSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDV
SKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEK
EEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQ
LLRGPQIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDIK
HSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPS
GVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFL
PEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRRE
KAIGEGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWP

--------------------------------------------------------------
>36971_36971_4_HMGXB3-PPARGC1B_HMGXB3_chr5_149386210_ENST00000503427_PPARGC1B_chr5_149199996_ENST00000394320_length(transcript)=5856nt_BP=1173nt
ATGAGAGGGAAAGACTGAGACAGGCTGAGGTCAGGCCTTGAACGTCGTGCTGAGGAGAGGGTGGTATTGTAGGCTTCCCAGCGCCCGACG
TGGCTCTGAAAGGTGAGGCGGGGCCTAGATCCCTCACGCTCAGCACAGCCCCGCCCCTGTTACCTGAACGCCCCACAGCAGTGCCCGGGG
GCTGAGCGGCCGGGGCGTCCCACCGCCGGCAGCCACAGCTTCCTCCTCCGCCCGGGACCTCTGGCCGGAAGCAGTCCGTTCGCCTTACTA
GACCCGCTCCAAGCCTTTGAGCAGTTCGTGTGGGTCCGCTCCCAAGCTAGGGCTGGGCTGTTGCGCTTGCGCCAGGGGTCGCATGCAGTC
ACGCGCTGCCGACCGCTTCCGGTGCGCCGCGAGGGCCGCCGGGACGGGTCTCCCTGGCGATCCGTGGTGTGCCGCTACTGCCGGTGCAGC
CGCCAAACCGGTGCCTCGGTGACGACCGTGTCCCTGCCGTCTTCCTCGAGCTCCCCGGGGCTTGACCCCCGGGGCCCTCGGCAGGCATCG
GTGAGGAGCCTGCGGAGCGAACCTGTGCTCCTATTCTTGCCCTTCAGGACCCCATATCGCGACTCCGAGGAGGGGAAGCGAGAGGGGCTG
TCGCGACTCCGCGCCGTGTGTCGCCGGGCGGGGCCGCGGGGCCGGGGCTCCTTCAGCCCCCGGGATGCGCGCGCGAGCCCTCGCCTCCAC
TTCCTTGTTGCTGCTGTCACGACTGGAGCCGCCTCTCGCCGACAGCGGGGAGCGCGAGTGCGCCAGCCATCCCCCTCGTCCAGCCGCCGG
GCCAAGCGCCTCCGGGAATGTGAGCGGCGCAGCTTGCACGCTCCTCCGGCCATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTG
ATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTCCTGGGCCACCCAAGAAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAG
AAACCCAGGTCTGCTTACCTTCTGTACTATTACGACATCTACCTGAAAGTGCAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAAT
AAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGGCCGAGAGGAGTTACTACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGAT
CCTGGTGGAGGGTCCGGGGAGGAGCAACTCTATGCTGACTTTCCAGAACTTGACCTCTCCCAGCTGGATGCCAGCGACTTTGACTCGGCC
ACCTGCTTTGGGGAGCTGCAGTGGTGCCCAGAGAACTCAGAGACTGAACCCAACCAGTACAGCCCCGATGACTCCGAGCTCTTCCAGATT
GACAGTGAGAATGAGGCCCTCCTGGCAGAGCTCACCAAGACCCTGGATGACATCCCTGAAGATGACGTGGGTCTGGCTGCCTTCCCAGCC
CTGGATGGTGGAGACGCTCTATCATGCACCTCAGCTTCGCCTGCCCCCTCATCTGCACCCCCCAGCCCTGCCCCGGAGAAGCCCTCGGCC
CCAGCCCCTGAGGTGGACGAGCTCTCACTGCTGCAGAAGCTCCTCCTGGCCACATCCTACCCAACATCAAGCTCTGACACCCAGAAGGAA
GGGACCGCCTGGCGCCAGGCAGGCCTCAGATCTAAAAGTCAACGGCCTTGTGTTAAGGCGGACAGCACCCAAGACAAGAAGGCTCCCATG
ATGCAGTCTCAGAGCCGAAGTTGTACAGAACTACATAAGCACCTCACCTCGGCACAGTGCTGCCTGCAGGATCGGGGTCTGCAGCCACCA
TGCCTCCAGAGTCCCCGGCTCCCTGCCAAGGAGGACAAGGAGCCGGGTGAGGACTGCCCGAGCCCCCAGCCAGCTCCAGCCTCTCCCCGG
GACTCCCTAGCTCTGGGCAGGGCAGACCCCGGTGCCCCGGTTTCCCAGGAAGACATGCAGGCGATGGTGCAACTCATACGCTACATGCAC
ACCTACTGCCTCCCCCAGAGGAAGCTGCCCCCACAGACCCCTGAGCCACTCCCCAAGGCCTGCAGCAACCCCTCCCAGCAGGTCAGATCC
CGGCCCTGGTCCCGGCACCACTCCAAAGCCTCCTGGGCTGAGTTCTCCATTCTGAGGGAACTTCTGGCTCAAGACGTGCTCTGTGATGTC
AGCAAACCCTACCGTCTGGCCACGCCTGTTTATGCCTCCCTCACACCTCGGTCAAGGCCCAGGCCCCCCAAAGACAGTCAGGCCTCCCCT
GGTCGCCCGTCCTCGGTGGAGGAGGTAAGGATCGCAGCTTCACCCAAGAGCACCGGGCCCAGACCAAGCCTGCGCCCACTGCGGCTGGAG
GTGAAAAGGGAGGTCCGCCGGCCTGCCAGACTGCAGCAGCAGGAGGAGGAAGACGAGGAAGAAGAGGAGGAGGAAGAGGAAGAAGAAAAA
GAGGAGGAGGAGGAGTGGGGCAGGAAAAGGCCAGGCCGAGGCCTGCCATGGACGAAGCTGGGGAGGAAGCTGGAGAGCTCTGTGTGCCCC
GTGCGGCGTTCTCGGAGACTGAACCCTGAGCTGGGCCCCTGGCTGACATTTGCAGATGAGCCGCTGGTCCCCTCGGAGCCCCAAGGTGCT
CTGCCCTCACTGTGCCTGGCTCCCAAGGCCTACGACGTAGAGCGGGAGCTGGGCAGCCCCACGGACGAGGACAGTGGCCAAGACCAGCAG
CTCCTACGGGGACCCCAGATCCCTGCCCTGGAGAGCCCCTGTGAGAGTGGGTGTGGGGACATGGATGAGGACCCCAGCTGCCCGCAGCTC
CCTCCCAGAGACTCTCCCAGGTGCCTCATGCTGGCCTTGTCACAAAGCGACCCAACTTTTGGCAAGAAGAGCTTTGAGCAGACCTTGACA
GTGGAGCTCTGTGGCACAGCAGGACTCACCCCACCCACCACACCACCGTACAAGCCCACAGAGGAGGATCCCTTCAAACCAGACATCAAG
CATAGTCTAGGCAAAGAAATAGCTCTCAGCCTCCCCTCCCCTGAGGGCCTCTCACTCAAGGCCACCCCAGGGGCTGCCCACAAGCTGCCA
AAGAAGCACCCAGAGCGAAGTGAGCTCCTGTCCCACCTGCGACATGCCACAGCCCAGCCAGCCTCCCAGGCTGGCCAGAAGCGTCCCTTC
TCCTGTTCCTTTGGAGACCATGACTACTGCCAGGTGCTCCGACCAGAAGGCGTCCTGCAAAGGAAGGTGCTGAGGTCCTGGGAGCCGTCT
GGGGTTCACCTTGAGGACTGGCCCCAGCAGGGTGCCCCTTGGGCTGAGGCACAGGCCCCTGGCAGGGAGGAAGACAGAAGCTGTGATGCT
GGCGCCCCACCCAAGGACAGCACGCTGCTGAGAGACCATGAGATCCGTGCCAGCCTCACCAAACACTTTGGGCTGCTGGAGACCGCCCTG
GAGGAGGAAGACCTGGCCTCCTGCAAGAGCCCTGAGTATGACACTGTCTTTGAAGACAGCAGCAGCAGCAGCGGCGAGAGCAGCTTCCTC
CCAGAGGAGGAAGAGGAAGAAGGGGAGGAGGAGGAGGAGGACGATGAAGAAGAGGACTCAGGGGTCAGCCCCACTTGCTCTGACCACTGC
CCCTACCAGAGCCCACCAAGCAAGGCCAACCGGCAGCTCTGTTCCCGCAGCCGCTCAAGCTCTGGCTCTTCACCCTGCCACTCCTGGTCA
CCAGCCACTCGAAGGAACTTCAGATGTGAGAGCAGAGGGCCGTGTTCAGACAGAACGCCAAGCATCCGGCACGCCAGGAAGCGGCGGGAA
AAGGCCATTGGGGAAGGCCGCGTGGTGTACATTCAAAATCTCTCCAGCGACATGAGCTCCCGAGAGCTGAAGAGGCGCTTTGAAGTGTTT
GGTGAGATTGAGGAGTGCGAGGTGCTGACAAGAAATAGGAGAGGCGAGAAGTACGGCTTCATCACCTACCGGTGTTCTGAGCACGCGGCC
CTCTCTTTGACAAAGGGCGCTGCCCTGAGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGCTACGGAGGGCTCCGGCACTTCTGCTGGCCC
AGATACACTGACTACGGTAAGCCCCTGAAACCCAGCCACAGTCTAGTAAGACTCAAAGCTTGGGAAGCAGTGCCTTCCTTGAACAAAACC
CAGAGCTAAAGCGCCTTGTGGACATAGCTTCCATCCCCACACCCCAGTGTGCTGCTTGGTATAACTTTGCAGCCACTTTGCCTGAAGACT
ACCATCCTGTTTCTCTTCTGGCCTCTGGTCCACCTTATCCTGTCCTGTGACTGCTACCAAAGAGAATCCAGCCTCCCACGGCCTCTAGGA
AGATTCAGTCATGTGCACAGCCAGCTGGCAGAACCGTGGCTACGGTCTCCTTGACTTCACAGGGCCAGCTGCTACCCTGTCCCCTTCAGG
GGCATTCCGTGGTGACCCCAGACAAGGCAGCAGCCACCTGGGGACAAGATGATGAAGAAGGACAAAGAAGTACAATGTACGAAAGAATTA
CTTGGCCAGGCTCAGTGGCTCATGCCTGTAATCCCATCACCTTGGGAGGCTGAGGCAAGAGGATCACTTGAGCCCAGGAGTTCGAGACCA
GCTTGGGCAACATAGTGAAATCCTGTCTCTACAAAAAATATAAAAATTAGCCAGGCATGGTGGCTTGCGCCTATAGTCCCAGCTACTCAG
GAGGCAGAGGTGGGAGGATCACCTGAACCCAAGAGGTTGGAGCTGCAGTGAGCCATGATGGCACTACTGCATTCCAGCCTGGGCAACAGA
GCAAGACCCTGTCTCAAAAGGAAAGAAAAAAAAAAAAACACTTACTGGAGAGAATCCAATGCAGCCTTGATGGTACAGGACTGAGTGTCA
GTGACCCGGCTGGGTGCCAGGCCAGGCGGCCCTGCCCTTGGCTGCATGTCCATTTATGGGAATCAGTTTCCCAATCTATTAAAAAATTCT
AGTGTTGGCTGGGTGCAGTTGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGAAGATCATGAGGTCAAGAGATCGAGACC
ATCGTGGCCAACATGGTGAAACCCCCTCTCTATTAAAAATACAAAAATTAGCTGGGCGTGGTGGCGCACACCTGTAGTCCCAGCAACTTG
GGAGGCTGAGGCGGGAGAATCACTTGAACCCGAGAGGCAGAGGTTGCAGTGAGCTGAGATCACATCCCTGCACTCCAGCCTTGGTGACAG
AGCGAGACTGCATCTCAAAAAAAAAAAAATTCTAGTGTTGTTAGCCCTCCCTTATGTGGCACTGCAGCAGGTTACTAATGGACGAGAAGC
TGTTGGGGGAAGTAGAGTTGTAGGGTGTTGGAGCTAGAAAGGCTCTGGAGTGCTCTAGTTTGGGCCTCCAGGTCTCTAGATAGGACAGCC
AAGGCCCTGAGACACTGATACCATGGCCAAGATGTCCCAGCAGGATGGCAGGCAGTGCCCACAGTCCAGCGCTCATCCCAGCTCCCCAAG
GCCTTGGGCTGCAGCCACTCCACGGTGCCCACTCATAGTGGCAGATTCTTCAACCATCCGGTCTTTGTAAGTTGCTCACTGCCTTCCCCT
CTTCCCTGCCTCTTCACCCCCATGCCCAGATTCCAATTCAGAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAGTATGAAGCCATGGATTT
TGACAGCTTACTGAAAGAGGCCCAGCAGAGCCTGCATTGATAACAGCCTTAACCCTCGAGGAATACCTCAATACCTCAGACAAGGCCCTT
CCAATATGTTTACGTTTTCAAAGAAATCAAGTATATGAGGAGAGCGAGCGAGCGTGAGAGAACACCCGTGAGAGAGACTTGAAACTGCTG

>36971_36971_4_HMGXB3-PPARGC1B_HMGXB3_chr5_149386210_ENST00000503427_PPARGC1B_chr5_149199996_ENST00000394320_length(amino acids)=1331AA_BP=340
MNAPQQCPGAERPGRPTAGSHSFLLRPGPLAGSSPFALLDPLQAFEQFVWVRSQARAGLLRLRQGSHAVTRCRPLPVRREGRRDGSPWRS
VVCRYCRCSRQTGASVTTVSLPSSSSSPGLDPRGPRQASVRSLRSEPVLLFLPFRTPYRDSEEGKREGLSRLRAVCRRAGPRGRGSFSPR
DARASPRLHFLVAAVTTGAASRRQRGARVRQPSPSSSRRAKRLRECERRSLHAPPAMDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKK
YKIHGEKTKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGLDPGGGSGEEQLYADFPELDLSQ
LDASDFDSATCFGELQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASPAPSSAPP
SPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCC
LQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASPRDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKAC
SNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPR
PSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTFADEP
LVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFG
KKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPA
SQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTK
HFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSSS
GSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGEGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFI

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Fusion Gene PPI Analysis for HMGXB3-PPARGC1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HMGXB3-PPARGC1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HMGXB3-PPARGC1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource