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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HNF1B-ANAPC16 (FusionGDB2 ID:37002)

Fusion Gene Summary for HNF1B-ANAPC16

Fusion gene summary

Fusion gene information	Fusion gene name: HNF1B-ANAPC16
	Fusion gene ID: 37002
		Hgene	Tgene
	Gene symbol	HNF1B	ANAPC16
	Gene ID	6928	119504
	Gene name	HNF1 homeobox B	anaphase promoting complex subunit 16
	Synonyms	FJHN\|HNF-1-beta\|HNF-1B\|HNF1beta\|HNF2\|HPC11\|LF-B3\|LFB3\|MODY5\|TCF-2\|TCF2\|VHNF1	APC16\|C10orf104\|CENP-27\|MSAG\|bA570G20.3
	Cytomap	17q12	10q22.1
	Type of gene	protein-coding	protein-coding
	Description	hepatocyte nuclear factor 1-betaHNF1 beta Ahomeoprotein LFB3transcription factor 2, hepatic	anaphase-promoting complex subunit 16centromere protein 27cyclosome subunit 16metabolic syndrome-associated protein
	Modification date	20200313	20200313
	UniProtAcc	P35680	Q96DE5
	Ensembl transtripts involved in fusion gene	ENST00000225893, ENST00000427275, ENST00000560016, ENST00000561193,	ENST00000470481, ENST00000299381,
Fusion gene scores	* DoF score	10 X 10 X 8=800	8 X 6 X 5=240
	# samples	10	10
	** MAII score	log2(10/800*10)=-3 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HNF1B [Title/Abstract] AND ANAPC16 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HNF1B(36091586)-ANAPC16(73990124), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HNF1B	GO:0001822	kidney development	21281489
Hgene	HNF1B	GO:0045893	positive regulation of transcription, DNA-templated	16297991\|21281489
Hgene	HNF1B	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	15355349
Tgene	ANAPC16	GO:0016567	protein ubiquitination	20360068

Fusion gene breakpoints across HNF1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANAPC16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRC	TCGA-CJ-4920-01A	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+

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Fusion Gene ORF analysis for HNF1B-ANAPC16

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000225893	ENST00000470481	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+
5CDS-3UTR	ENST00000427275	ENST00000470481	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+
5CDS-3UTR	ENST00000560016	ENST00000470481	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+
5CDS-3UTR	ENST00000561193	ENST00000470481	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+
In-frame	ENST00000225893	ENST00000299381	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+
In-frame	ENST00000427275	ENST00000299381	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+
In-frame	ENST00000560016	ENST00000299381	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+
In-frame	ENST00000561193	ENST00000299381	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000225893	HNF1B	chr17	36091586	-	ENST00000299381	ANAPC16	chr10	73990124	+	4342	1407	362	1597	411
ENST00000561193	HNF1B	chr17	36091586	-	ENST00000299381	ANAPC16	chr10	73990124	+	4077	1142	175	1332	385
ENST00000560016	HNF1B	chr17	36091586	-	ENST00000299381	ANAPC16	chr10	73990124	+	4114	1179	134	1369	411
ENST00000427275	HNF1B	chr17	36091586	-	ENST00000299381	ANAPC16	chr10	73990124	+	4036	1101	134	1291	385

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000225893	ENST00000299381	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+	0.000911174	0.9990889
ENST00000561193	ENST00000299381	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+	0.00087509	0.99912494
ENST00000560016	ENST00000299381	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+	0.000820565	0.9991794
ENST00000427275	ENST00000299381	HNF1B	chr17	36091586	-	ANAPC16	chr10	73990124	+	0.000864417	0.99913555

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Fusion Genomic Features for HNF1B-ANAPC16

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HNF1B	chr17	36091585	-	ANAPC16	chr10	73990123	+	0.002556813	0.9974432
HNF1B	chr17	36091585	-	ANAPC16	chr10	73990123	+	0.002556813	0.9974432

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HNF1B-ANAPC16

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:36091586/chr10:73990124)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HNF1B P35680	ANAPC16 Q96DE5
FUNCTION: Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269\|PubMed:20360068}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HNF1B

chr17:36091586

chr10:73990124

ENST00000225893

231_311

348

558.0

DNA binding

Homeobox%3B HNF1-type

Hgene

HNF1B

chr17:36091586

chr10:73990124

ENST00000427275

231_311

322

458.0

DNA binding

Homeobox%3B HNF1-type

Hgene

HNF1B

chr17:36091586

chr10:73990124

ENST00000561193

231_311

322

532.0

DNA binding

Homeobox%3B HNF1-type

Hgene

HNF1B

chr17:36091586

chr10:73990124

ENST00000225893

1_32

348

558.0

Domain

HNF-p1

Hgene

HNF1B

chr17:36091586

chr10:73990124

ENST00000225893

93_188

348

558.0

Domain

POU-specific atypical

Hgene

HNF1B

chr17:36091586

chr10:73990124

ENST00000427275

1_32

322

458.0

Domain

HNF-p1

Hgene

HNF1B

chr17:36091586

chr10:73990124

ENST00000427275

93_188

322

458.0

Domain

POU-specific atypical

Hgene

HNF1B

chr17:36091586

chr10:73990124

ENST00000561193

1_32

322

532.0

Domain

HNF-p1

Hgene

HNF1B

chr17:36091586

chr10:73990124

ENST00000561193

93_188

322

532.0

Domain

POU-specific atypical

Hgene

HNF1B

chr17:36091586

chr10:73990124

ENST00000225893

1_31

348

558.0

Region

Dimerization

Hgene

HNF1B

chr17:36091586

chr10:73990124

ENST00000427275

1_31

322

458.0

Region

Dimerization

Hgene

HNF1B

chr17:36091586

chr10:73990124

ENST00000561193

1_31

322

532.0

Region

Dimerization

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ANAPC16

chr17:36091586

chr10:73990124

ENST00000299381

4_26

111.0

Compositional bias

Note=Ser-rich

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Fusion Gene Sequence for HNF1B-ANAPC16

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>37002_37002_1_HNF1B-ANAPC16_HNF1B_chr17_36091586_ENST00000225893_ANAPC16_chr10_73990124_ENST00000299381_length(transcript)=4342nt_BP=1407nt
GAGTACAATGGACCCTGGCAAAGCCCCGCTCCCGGCCCAGGTCTTCTGCTCTCCAGGTCTGCCCCTCCGGCTCTCCCTCTCTCCGGGTTT
CCCCCTCCCCACCATCATTTGCATCCAGCCGAAAGCTGGGCCCTTCCCACTAATTTGCATATCTTATATGGCCTAATGGTGGCGATCATG
GCAAGTTAGAAGTTTTCTGACTCCTTTCGGAGGAGCCTCCGGGACCCCGGGGAGTAACAGGTGTCTGGAGGCTGAAGGGTGGAGGGGTTC
CTGGATTTGGGGTTTGCTTGTGAAACTCCCCTCCACCCTCCTCTCTCGCACCCACCCACCCCCTCACCCCCTTCTTTTTCCGTCCTTGGA
AAATGGTGTCCAAGCTCACGTCGCTCCAGCAAGAACTCCTGAGCGCCCTGCTGAGCTCCGGGGTCACCAAGGAGGTGCTGGTTCAGGCCT
TGGAGGAGTTGCTGCCATCCCCGAACTTCGGGGTGAAGCTGGAGACGCTGCCCCTGTCCCCTGGCAGCGGGGCCGAGCCCGACACCAAGC
CGGTCTTCCATACTCTCACCAACGGCCACGCCAAGGGCCGCTTGTCCGGCGACGAGGGCTCCGAGGACGGCGACGACTATGACACACCTC
CCATCCTCAAGGAGCTGCAGGCGCTCAACACCGAGGAGGCGGCGGAGCAGCGGGCGGAGGTGGACCGGATGCTCAGTGAGGACCCTTGGA
GGGCTGCTAAAATGATCAAGGGTTACATGCAGCAACACAACATCCCCCAGAGGGAGGTGGTCGATGTCACCGGCCTGAACCAGTCGCACC
TCTCCCAGCATCTCAACAAGGGCACCCCTATGAAGACCCAGAAGCGTGCCGCTCTGTACACCTGGTACGTCAGAAAGCAACGAGAGATCC
TCCGACAATTCAACCAGACAGTCCAGAGTTCTGGAAATATGACAGACAAAAGCAGTCAGGATCAGCTGCTGTTTCTCTTTCCAGAGTTCA
GTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAACCGGTTCAAATGGGGGC
CCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAGGAATGCAACA
GGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGTCCGTGTCTACAACTGGT
TTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCACAGCCTGAACCCTCTGC
TCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGATGGCTCTGAGAGATTCCTCTGCGAATCTGTTT
TTAGCTATCAAGTGGCATCCACGCTTAAACAGGTGAAACATGATCAGCAAGTTGCTCGGATGGAAAAACTAGCTGGTTTGGTAGAAGAGC
TGGAGGCTGACGAGTGGCGGTTTAAGCCCATCGAGCAGCTGCTGGGATTCACCCCCTCTTCAGGTTGATACTGCCTGGATGGTCACCTCT
GGTGCGCAGCAAGTGCAAAGCCAGTGGGGGACTTTCTCACAGCTTACATAGCCATCCAGAGATCCACAGCTACGTCACTGAATTGTTAAT
GCACATTTGTACTTGGTTTCTCTGTATCTATTCACAGGCAACAAATACTTATATGTGTGATCTTTCAGGGAATGTTTTGTTTATTTGTTT
TTAAAAGTATTGGGAATCAGATTAAGACAATCAGTTTCAGAGAACCAGGAGGTTTGGGGTTAAGAGATACTCAAAAATTTTCACAAGCCA
AGTAGGGCATATATCAGATTTGGCCAACTGAATGGCGTCTGTCCTGTCATCCATATGGTGCCTGGAAATATTTACCAGTCAAGGTCAAGG
TCAGCATCTGTGGTTAAAAATATAGCATTCTGACCTAAAAAAGTTATTTTGCAGATGAATGTGTTTTCAACTCAGGACCTATCCAAATGA
GGAATTTTTAAATATTCTTTTTTTTTTCCTATTTTTAGACATCAATTCTATAGATTCTGACTTTTTCTAACCTCTTATAGACATGCCAAA
TGCTGGCAAAAAGAAGTGCTTTTTGGATATGGCAGCACTTGTAAAAATAAAGCAGTAAGCAAAATCCTTTTAAACACAGAAATCCTGAGT
TCTTCTCATTGGTGGACTCAAGCAATTCTGTAGCAAATAAATCCTTTGAAAGAGCTCCAAATTGGTGGCATTATCCTTTCAAAATCTCAG
GGATTTGGGATGAAGTGAAGAGGTCAAATTACTTTTTAGAAGAAGGGAATCTAAAAACCATCTCTCCTAAACAAATGGTAGACTGGCTTT
ACTTAAGGGATATTTGTCTTTATAGGAGTACATAAATTTATCTTAATGATATTTAAGTAGTTTTTTTTTTTTTTTGAGACGAAGTTTTGC
TCTTGTTGCCCAGGCTGTATCGCAATGGCGCGATCTCTGCTCACTGCAACATCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCT
CCCAAGTAGCTGGGATTACAGGCACCCGCCACCACACCCAGCTAATTTTTTGTATATTTAGTAGAGACGGGGTTTCACCATGTTGACCAG
GCTAGTCTCGAACTTCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAATTGCTGGGATTACAGGCGTGAGCCACCTTGCCCAGCCA
ATTTTTTTTTAAAGAGACATGGTCTTGCTATGTTGCCCAGGTTGGTCTTGAACTCCTGGCCTCAAGAGATCCCCCCAACCTTGGCCTCCA
AAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTCAAGTAAGTTTTTATACCATGATAGGGGAAAACCTGGAAGGCTAAGAGAT
GTGCTGTTTTCCTTCATGGGACCCCACTTTCCACAGTAAACAACTGGTATAATCATTTATTACGTTGTATGCAAATTTTGCCTTAGACAA
CATTTGTCTGGTTCCTTATTAATAACTTGCATCTGATCTGCTTAGAGTTGCTTAATTATAAGTAAATATAATCCCAGTAGCATTTAGCCT
TAATCTCAAGAGTTCAAAATGTTTAACACATTCTACCTGACGGGAGGTGGTGACCTCATTCAGTCGGTTAAGAGCCTGAGCCCTGTGAAG
TTAAACACCTGCTCATGGTCACATAGCCCAGGCAGAAGAAAATCTCGGACTTGGAATAGATCCCAGTTGCCTGATAATTCATCTCATTAT
TGCCTCTAAAGCAAATTGGAGACTGGGCACAGTGGCTCCCACCTTTAATCCCAGCACCTGGGGAGGCTGAGGTGAGTGGATCACTAGAGG
TCAGGAGTTCAAGACCAGTCTGGCCGACATGGTGAAACTCAGTCTCTATTGAAAATACAAAAATTAGCTCAGTGTGGTGGCACACACTTG
TAATCCCAGCTACTCAGGAGGCTGAGGCATGAGAATCGCTTAAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCACACCATTGCACT
CTAGTCTGGGTGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAATAAAGCCGGGCGTGGTGGCTCACGCCTGTAATCCCGGCACTTTGG
GAGGCTGAGGCAGGCGGATTGCCTGAGATCGGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCTTGTCTCTACTAAAACTACAAAA
AAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGCAGAATCGTTTGAACCCGGGAGGCGGAGG
TTGCAGTGAGTGGAGATCGTGCCTGTGTGCTCCAGCCTGAGCAACAAGAGCGAAACTGTCTCAAAAAAAAGAAGAAAATAAATAAATAAA
AATCAGAGCACAAGAAGTACCAGTCCACCAACTCACATTTTCTATATTAATAATTCTTAACTAAAAGAAGTTCCATATTCGACAGCATTT
TAGTTTTTTAATAGTACTTATTAGCATCAACCATCTTGATAATCACCAAGGGAAAAATTAAAAATACCTAGACTGCAATAAACCTTTAAA
TTGGATTTTCAGTGAGAATTTAGAAGCAATCACTACCTTTCTCGTTTCATTTGTGTAACCATGCAGCATAGGCACTGTGTTACATCATCT
TTACGCTTTGGTATTTGAACTTATTACAGAATTTTTTCTCTAAATTGGATGTTTCTTTATATGACCTTGGAAACTGAAGTGATCTTAGCA

>37002_37002_1_HNF1B-ANAPC16_HNF1B_chr17_36091586_ENST00000225893_ANAPC16_chr10_73990124_ENST00000299381_length(amino acids)=411AA_BP=348
MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPP
ILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIL
RQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNR
AECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSDGSERFLCESVF

--------------------------------------------------------------
>37002_37002_2_HNF1B-ANAPC16_HNF1B_chr17_36091586_ENST00000427275_ANAPC16_chr10_73990124_ENST00000299381_length(transcript)=4036nt_BP=1101nt
GGGGAGTAACAGGTGTCTGGAGGCTGAAGGGTGGAGGGGTTCCTGGATTTGGGGTTTGCTTGTGAAACTCCCCTCCACCCTCCTCTCTCG
CACCCACCCACCCCCTCACCCCCTTCTTTTTCCGTCCTTGGAAAATGGTGTCCAAGCTCACGTCGCTCCAGCAAGAACTCCTGAGCGCCC
TGCTGAGCTCCGGGGTCACCAAGGAGGTGCTGGTTCAGGCCTTGGAGGAGTTGCTGCCATCCCCGAACTTCGGGGTGAAGCTGGAGACGC
TGCCCCTGTCCCCTGGCAGCGGGGCCGAGCCCGACACCAAGCCGGTCTTCCATACTCTCACCAACGGCCACGCCAAGGGCCGCTTGTCCG
GCGACGAGGGCTCCGAGGACGGCGACGACTATGACACACCTCCCATCCTCAAGGAGCTGCAGGCGCTCAACACCGAGGAGGCGGCGGAGC
AGCGGGCGGAGGTGGACCGGATGCTCAGTGAGGACCCTTGGAGGGCTGCTAAAATGATCAAGGGTTACATGCAGCAACACAACATCCCCC
AGAGGGAGGTGGTCGATGTCACCGGCCTGAACCAGTCGCACCTCTCCCAGCATCTCAACAAGGGCACCCCTATGAAGACCCAGAAGCGTG
CCGCTCTGTACACCTGGTACGTCAGAAAGCAACGAGAGATCCTCCGACAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATG
CCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAACCGGTTCAAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATC
GGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAGGAATGCAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCA
AAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGTCCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAA
AGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCACAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCT
CTCCTCCAAACAAGCTGTCAGATGGCTCTGAGAGATTCCTCTGCGAATCTGTTTTTAGCTATCAAGTGGCATCCACGCTTAAACAGGTGA
AACATGATCAGCAAGTTGCTCGGATGGAAAAACTAGCTGGTTTGGTAGAAGAGCTGGAGGCTGACGAGTGGCGGTTTAAGCCCATCGAGC
AGCTGCTGGGATTCACCCCCTCTTCAGGTTGATACTGCCTGGATGGTCACCTCTGGTGCGCAGCAAGTGCAAAGCCAGTGGGGGACTTTC
TCACAGCTTACATAGCCATCCAGAGATCCACAGCTACGTCACTGAATTGTTAATGCACATTTGTACTTGGTTTCTCTGTATCTATTCACA
GGCAACAAATACTTATATGTGTGATCTTTCAGGGAATGTTTTGTTTATTTGTTTTTAAAAGTATTGGGAATCAGATTAAGACAATCAGTT
TCAGAGAACCAGGAGGTTTGGGGTTAAGAGATACTCAAAAATTTTCACAAGCCAAGTAGGGCATATATCAGATTTGGCCAACTGAATGGC
GTCTGTCCTGTCATCCATATGGTGCCTGGAAATATTTACCAGTCAAGGTCAAGGTCAGCATCTGTGGTTAAAAATATAGCATTCTGACCT
AAAAAAGTTATTTTGCAGATGAATGTGTTTTCAACTCAGGACCTATCCAAATGAGGAATTTTTAAATATTCTTTTTTTTTTCCTATTTTT
AGACATCAATTCTATAGATTCTGACTTTTTCTAACCTCTTATAGACATGCCAAATGCTGGCAAAAAGAAGTGCTTTTTGGATATGGCAGC
ACTTGTAAAAATAAAGCAGTAAGCAAAATCCTTTTAAACACAGAAATCCTGAGTTCTTCTCATTGGTGGACTCAAGCAATTCTGTAGCAA
ATAAATCCTTTGAAAGAGCTCCAAATTGGTGGCATTATCCTTTCAAAATCTCAGGGATTTGGGATGAAGTGAAGAGGTCAAATTACTTTT
TAGAAGAAGGGAATCTAAAAACCATCTCTCCTAAACAAATGGTAGACTGGCTTTACTTAAGGGATATTTGTCTTTATAGGAGTACATAAA
TTTATCTTAATGATATTTAAGTAGTTTTTTTTTTTTTTTGAGACGAAGTTTTGCTCTTGTTGCCCAGGCTGTATCGCAATGGCGCGATCT
CTGCTCACTGCAACATCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCACCACA
CCCAGCTAATTTTTTGTATATTTAGTAGAGACGGGGTTTCACCATGTTGACCAGGCTAGTCTCGAACTTCTGACCTCAGGTGATCCACCT
GCCTCAGCCTCCCAAATTGCTGGGATTACAGGCGTGAGCCACCTTGCCCAGCCAATTTTTTTTTAAAGAGACATGGTCTTGCTATGTTGC
CCAGGTTGGTCTTGAACTCCTGGCCTCAAGAGATCCCCCCAACCTTGGCCTCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTG
GCCTCAAGTAAGTTTTTATACCATGATAGGGGAAAACCTGGAAGGCTAAGAGATGTGCTGTTTTCCTTCATGGGACCCCACTTTCCACAG
TAAACAACTGGTATAATCATTTATTACGTTGTATGCAAATTTTGCCTTAGACAACATTTGTCTGGTTCCTTATTAATAACTTGCATCTGA
TCTGCTTAGAGTTGCTTAATTATAAGTAAATATAATCCCAGTAGCATTTAGCCTTAATCTCAAGAGTTCAAAATGTTTAACACATTCTAC
CTGACGGGAGGTGGTGACCTCATTCAGTCGGTTAAGAGCCTGAGCCCTGTGAAGTTAAACACCTGCTCATGGTCACATAGCCCAGGCAGA
AGAAAATCTCGGACTTGGAATAGATCCCAGTTGCCTGATAATTCATCTCATTATTGCCTCTAAAGCAAATTGGAGACTGGGCACAGTGGC
TCCCACCTTTAATCCCAGCACCTGGGGAGGCTGAGGTGAGTGGATCACTAGAGGTCAGGAGTTCAAGACCAGTCTGGCCGACATGGTGAA
ACTCAGTCTCTATTGAAAATACAAAAATTAGCTCAGTGTGGTGGCACACACTTGTAATCCCAGCTACTCAGGAGGCTGAGGCATGAGAAT
CGCTTAAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCACACCATTGCACTCTAGTCTGGGTGACAGAGCGAGACTCTGTCTCAAAA
AAAAAAAAATAAAGCCGGGCGTGGTGGCTCACGCCTGTAATCCCGGCACTTTGGGAGGCTGAGGCAGGCGGATTGCCTGAGATCGGGAGT
TCGAGACCAGCCTGGCCAACATGGTGAAACCTTGTCTCTACTAAAACTACAAAAAAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAATC
CCAGCTACTCAGGAGGCTGAGGCAGCAGAATCGTTTGAACCCGGGAGGCGGAGGTTGCAGTGAGTGGAGATCGTGCCTGTGTGCTCCAGC
CTGAGCAACAAGAGCGAAACTGTCTCAAAAAAAAGAAGAAAATAAATAAATAAAAATCAGAGCACAAGAAGTACCAGTCCACCAACTCAC
ATTTTCTATATTAATAATTCTTAACTAAAAGAAGTTCCATATTCGACAGCATTTTAGTTTTTTAATAGTACTTATTAGCATCAACCATCT
TGATAATCACCAAGGGAAAAATTAAAAATACCTAGACTGCAATAAACCTTTAAATTGGATTTTCAGTGAGAATTTAGAAGCAATCACTAC
CTTTCTCGTTTCATTTGTGTAACCATGCAGCATAGGCACTGTGTTACATCATCTTTACGCTTTGGTATTTGAACTTATTACAGAATTTTT

>37002_37002_2_HNF1B-ANAPC16_HNF1B_chr17_36091586_ENST00000427275_ANAPC16_chr10_73990124_ENST00000299381_length(amino acids)=385AA_BP=322
MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPP
ILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIL
RQFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRV
YNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSDGSERFLCESVFSYQVASTLKQVKHDQQVARMEKLAGL

--------------------------------------------------------------
>37002_37002_3_HNF1B-ANAPC16_HNF1B_chr17_36091586_ENST00000560016_ANAPC16_chr10_73990124_ENST00000299381_length(transcript)=4114nt_BP=1179nt
GGGGAGTAACAGGTGTCTGGAGGCTGAAGGGTGGAGGGGTTCCTGGATTTGGGGTTTGCTTGTGAAACTCCCCTCCACCCTCCTCTCTCG
CACCCACCCACCCCCTCACCCCCTTCTTTTTCCGTCCTTGGAAAATGGTGTCCAAGCTCACGTCGCTCCAGCAAGAACTCCTGAGCGCCC
TGCTGAGCTCCGGGGTCACCAAGGAGGTGCTGGTTCAGGCCTTGGAGGAGTTGCTGCCATCCCCGAACTTCGGGGTGAAGCTGGAGACGC
TGCCCCTGTCCCCTGGCAGCGGGGCCGAGCCCGACACCAAGCCGGTCTTCCATACTCTCACCAACGGCCACGCCAAGGGCCGCTTGTCCG
GCGACGAGGGCTCCGAGGACGGCGACGACTATGACACACCTCCCATCCTCAAGGAGCTGCAGGCGCTCAACACCGAGGAGGCGGCGGAGC
AGCGGGCGGAGGTGGACCGGATGCTCAGTGAGGACCCTTGGAGGGCTGCTAAAATGATCAAGGGTTACATGCAGCAACACAACATCCCCC
AGAGGGAGGTGGTCGATGTCACCGGCCTGAACCAGTCGCACCTCTCCCAGCATCTCAACAAGGGCACCCCTATGAAGACCCAGAAGCGTG
CCGCTCTGTACACCTGGTACGTCAGAAAGCAACGAGAGATCCTCCGACAATTCAACCAGACAGTCCAGAGTTCTGGAAATATGACAGACA
AAAGCAGTCAGGATCAGCTGCTGTTTCTCTTTCCAGAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGC
CCACCAACAAGAAGATGCGCCGCAACCGGTTCAAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACC
CCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAGGAATGCAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCC
TGGGCTCCAACTTGGTCACTGAGGTCCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGG
ACGCCTATAGCTCCAACCAGACTCACAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACA
AGCTGTCAGATGGCTCTGAGAGATTCCTCTGCGAATCTGTTTTTAGCTATCAAGTGGCATCCACGCTTAAACAGGTGAAACATGATCAGC
AAGTTGCTCGGATGGAAAAACTAGCTGGTTTGGTAGAAGAGCTGGAGGCTGACGAGTGGCGGTTTAAGCCCATCGAGCAGCTGCTGGGAT
TCACCCCCTCTTCAGGTTGATACTGCCTGGATGGTCACCTCTGGTGCGCAGCAAGTGCAAAGCCAGTGGGGGACTTTCTCACAGCTTACA
TAGCCATCCAGAGATCCACAGCTACGTCACTGAATTGTTAATGCACATTTGTACTTGGTTTCTCTGTATCTATTCACAGGCAACAAATAC
TTATATGTGTGATCTTTCAGGGAATGTTTTGTTTATTTGTTTTTAAAAGTATTGGGAATCAGATTAAGACAATCAGTTTCAGAGAACCAG
GAGGTTTGGGGTTAAGAGATACTCAAAAATTTTCACAAGCCAAGTAGGGCATATATCAGATTTGGCCAACTGAATGGCGTCTGTCCTGTC
ATCCATATGGTGCCTGGAAATATTTACCAGTCAAGGTCAAGGTCAGCATCTGTGGTTAAAAATATAGCATTCTGACCTAAAAAAGTTATT
TTGCAGATGAATGTGTTTTCAACTCAGGACCTATCCAAATGAGGAATTTTTAAATATTCTTTTTTTTTTCCTATTTTTAGACATCAATTC
TATAGATTCTGACTTTTTCTAACCTCTTATAGACATGCCAAATGCTGGCAAAAAGAAGTGCTTTTTGGATATGGCAGCACTTGTAAAAAT
AAAGCAGTAAGCAAAATCCTTTTAAACACAGAAATCCTGAGTTCTTCTCATTGGTGGACTCAAGCAATTCTGTAGCAAATAAATCCTTTG
AAAGAGCTCCAAATTGGTGGCATTATCCTTTCAAAATCTCAGGGATTTGGGATGAAGTGAAGAGGTCAAATTACTTTTTAGAAGAAGGGA
ATCTAAAAACCATCTCTCCTAAACAAATGGTAGACTGGCTTTACTTAAGGGATATTTGTCTTTATAGGAGTACATAAATTTATCTTAATG
ATATTTAAGTAGTTTTTTTTTTTTTTTGAGACGAAGTTTTGCTCTTGTTGCCCAGGCTGTATCGCAATGGCGCGATCTCTGCTCACTGCA
ACATCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCACCACACCCAGCTAATTT
TTTGTATATTTAGTAGAGACGGGGTTTCACCATGTTGACCAGGCTAGTCTCGAACTTCTGACCTCAGGTGATCCACCTGCCTCAGCCTCC
CAAATTGCTGGGATTACAGGCGTGAGCCACCTTGCCCAGCCAATTTTTTTTTAAAGAGACATGGTCTTGCTATGTTGCCCAGGTTGGTCT
TGAACTCCTGGCCTCAAGAGATCCCCCCAACCTTGGCCTCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTCAAGTAAG
TTTTTATACCATGATAGGGGAAAACCTGGAAGGCTAAGAGATGTGCTGTTTTCCTTCATGGGACCCCACTTTCCACAGTAAACAACTGGT
ATAATCATTTATTACGTTGTATGCAAATTTTGCCTTAGACAACATTTGTCTGGTTCCTTATTAATAACTTGCATCTGATCTGCTTAGAGT
TGCTTAATTATAAGTAAATATAATCCCAGTAGCATTTAGCCTTAATCTCAAGAGTTCAAAATGTTTAACACATTCTACCTGACGGGAGGT
GGTGACCTCATTCAGTCGGTTAAGAGCCTGAGCCCTGTGAAGTTAAACACCTGCTCATGGTCACATAGCCCAGGCAGAAGAAAATCTCGG
ACTTGGAATAGATCCCAGTTGCCTGATAATTCATCTCATTATTGCCTCTAAAGCAAATTGGAGACTGGGCACAGTGGCTCCCACCTTTAA
TCCCAGCACCTGGGGAGGCTGAGGTGAGTGGATCACTAGAGGTCAGGAGTTCAAGACCAGTCTGGCCGACATGGTGAAACTCAGTCTCTA
TTGAAAATACAAAAATTAGCTCAGTGTGGTGGCACACACTTGTAATCCCAGCTACTCAGGAGGCTGAGGCATGAGAATCGCTTAAACCCA
GGAGGCGGAGGTTGCAGTGAGCTGAGATCACACCATTGCACTCTAGTCTGGGTGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAATAA
AGCCGGGCGTGGTGGCTCACGCCTGTAATCCCGGCACTTTGGGAGGCTGAGGCAGGCGGATTGCCTGAGATCGGGAGTTCGAGACCAGCC
TGGCCAACATGGTGAAACCTTGTCTCTACTAAAACTACAAAAAAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAATCCCAGCTACTCAG
GAGGCTGAGGCAGCAGAATCGTTTGAACCCGGGAGGCGGAGGTTGCAGTGAGTGGAGATCGTGCCTGTGTGCTCCAGCCTGAGCAACAAG
AGCGAAACTGTCTCAAAAAAAAGAAGAAAATAAATAAATAAAAATCAGAGCACAAGAAGTACCAGTCCACCAACTCACATTTTCTATATT
AATAATTCTTAACTAAAAGAAGTTCCATATTCGACAGCATTTTAGTTTTTTAATAGTACTTATTAGCATCAACCATCTTGATAATCACCA
AGGGAAAAATTAAAAATACCTAGACTGCAATAAACCTTTAAATTGGATTTTCAGTGAGAATTTAGAAGCAATCACTACCTTTCTCGTTTC
ATTTGTGTAACCATGCAGCATAGGCACTGTGTTACATCATCTTTACGCTTTGGTATTTGAACTTATTACAGAATTTTTTCTCTAAATTGG

>37002_37002_3_HNF1B-ANAPC16_HNF1B_chr17_36091586_ENST00000560016_ANAPC16_chr10_73990124_ENST00000299381_length(amino acids)=411AA_BP=348
MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPP
ILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIL
RQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNR
AECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSDGSERFLCESVF

--------------------------------------------------------------
>37002_37002_4_HNF1B-ANAPC16_HNF1B_chr17_36091586_ENST00000561193_ANAPC16_chr10_73990124_ENST00000299381_length(transcript)=4077nt_BP=1142nt
AGAAGTTTTCTGACTCCTTTCGGAGGAGCCTCCGGGACCCCGGGGAGTAACAGGTGTCTGGAGGCTGAAGGGTGGAGGGGTTCCTGGATT
TGGGGTTTGCTTGTGAAACTCCCCTCCACCCTCCTCTCTCGCACCCACCCACCCCCTCACCCCCTTCTTTTTCCGTCCTTGGAAAATGGT
GTCCAAGCTCACGTCGCTCCAGCAAGAACTCCTGAGCGCCCTGCTGAGCTCCGGGGTCACCAAGGAGGTGCTGGTTCAGGCCTTGGAGGA
GTTGCTGCCATCCCCGAACTTCGGGGTGAAGCTGGAGACGCTGCCCCTGTCCCCTGGCAGCGGGGCCGAGCCCGACACCAAGCCGGTCTT
CCATACTCTCACCAACGGCCACGCCAAGGGCCGCTTGTCCGGCGACGAGGGCTCCGAGGACGGCGACGACTATGACACACCTCCCATCCT
CAAGGAGCTGCAGGCGCTCAACACCGAGGAGGCGGCGGAGCAGCGGGCGGAGGTGGACCGGATGCTCAGTGAGGACCCTTGGAGGGCTGC
TAAAATGATCAAGGGTTACATGCAGCAACACAACATCCCCCAGAGGGAGGTGGTCGATGTCACCGGCCTGAACCAGTCGCACCTCTCCCA
GCATCTCAACAAGGGCACCCCTATGAAGACCCAGAAGCGTGCCGCTCTGTACACCTGGTACGTCAGAAAGCAACGAGAGATCCTCCGACA
GTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAACCGGTTCAAATG
GGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAGGAATG
CAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGTCCGTGTCTACAA
CTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCACAGCCTGAACCC
TCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGATGGCTCTGAGAGATTCCTCTGCGAATC
TGTTTTTAGCTATCAAGTGGCATCCACGCTTAAACAGGTGAAACATGATCAGCAAGTTGCTCGGATGGAAAAACTAGCTGGTTTGGTAGA
AGAGCTGGAGGCTGACGAGTGGCGGTTTAAGCCCATCGAGCAGCTGCTGGGATTCACCCCCTCTTCAGGTTGATACTGCCTGGATGGTCA
CCTCTGGTGCGCAGCAAGTGCAAAGCCAGTGGGGGACTTTCTCACAGCTTACATAGCCATCCAGAGATCCACAGCTACGTCACTGAATTG
TTAATGCACATTTGTACTTGGTTTCTCTGTATCTATTCACAGGCAACAAATACTTATATGTGTGATCTTTCAGGGAATGTTTTGTTTATT
TGTTTTTAAAAGTATTGGGAATCAGATTAAGACAATCAGTTTCAGAGAACCAGGAGGTTTGGGGTTAAGAGATACTCAAAAATTTTCACA
AGCCAAGTAGGGCATATATCAGATTTGGCCAACTGAATGGCGTCTGTCCTGTCATCCATATGGTGCCTGGAAATATTTACCAGTCAAGGT
CAAGGTCAGCATCTGTGGTTAAAAATATAGCATTCTGACCTAAAAAAGTTATTTTGCAGATGAATGTGTTTTCAACTCAGGACCTATCCA
AATGAGGAATTTTTAAATATTCTTTTTTTTTTCCTATTTTTAGACATCAATTCTATAGATTCTGACTTTTTCTAACCTCTTATAGACATG
CCAAATGCTGGCAAAAAGAAGTGCTTTTTGGATATGGCAGCACTTGTAAAAATAAAGCAGTAAGCAAAATCCTTTTAAACACAGAAATCC
TGAGTTCTTCTCATTGGTGGACTCAAGCAATTCTGTAGCAAATAAATCCTTTGAAAGAGCTCCAAATTGGTGGCATTATCCTTTCAAAAT
CTCAGGGATTTGGGATGAAGTGAAGAGGTCAAATTACTTTTTAGAAGAAGGGAATCTAAAAACCATCTCTCCTAAACAAATGGTAGACTG
GCTTTACTTAAGGGATATTTGTCTTTATAGGAGTACATAAATTTATCTTAATGATATTTAAGTAGTTTTTTTTTTTTTTTGAGACGAAGT
TTTGCTCTTGTTGCCCAGGCTGTATCGCAATGGCGCGATCTCTGCTCACTGCAACATCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTC
AGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCACCACACCCAGCTAATTTTTTGTATATTTAGTAGAGACGGGGTTTCACCATGTTG
ACCAGGCTAGTCTCGAACTTCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAATTGCTGGGATTACAGGCGTGAGCCACCTTGCCC
AGCCAATTTTTTTTTAAAGAGACATGGTCTTGCTATGTTGCCCAGGTTGGTCTTGAACTCCTGGCCTCAAGAGATCCCCCCAACCTTGGC
CTCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTCAAGTAAGTTTTTATACCATGATAGGGGAAAACCTGGAAGGCTAA
GAGATGTGCTGTTTTCCTTCATGGGACCCCACTTTCCACAGTAAACAACTGGTATAATCATTTATTACGTTGTATGCAAATTTTGCCTTA
GACAACATTTGTCTGGTTCCTTATTAATAACTTGCATCTGATCTGCTTAGAGTTGCTTAATTATAAGTAAATATAATCCCAGTAGCATTT
AGCCTTAATCTCAAGAGTTCAAAATGTTTAACACATTCTACCTGACGGGAGGTGGTGACCTCATTCAGTCGGTTAAGAGCCTGAGCCCTG
TGAAGTTAAACACCTGCTCATGGTCACATAGCCCAGGCAGAAGAAAATCTCGGACTTGGAATAGATCCCAGTTGCCTGATAATTCATCTC
ATTATTGCCTCTAAAGCAAATTGGAGACTGGGCACAGTGGCTCCCACCTTTAATCCCAGCACCTGGGGAGGCTGAGGTGAGTGGATCACT
AGAGGTCAGGAGTTCAAGACCAGTCTGGCCGACATGGTGAAACTCAGTCTCTATTGAAAATACAAAAATTAGCTCAGTGTGGTGGCACAC
ACTTGTAATCCCAGCTACTCAGGAGGCTGAGGCATGAGAATCGCTTAAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCACACCATT
GCACTCTAGTCTGGGTGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAATAAAGCCGGGCGTGGTGGCTCACGCCTGTAATCCCGGCAC
TTTGGGAGGCTGAGGCAGGCGGATTGCCTGAGATCGGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCTTGTCTCTACTAAAACTA
CAAAAAAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGCAGAATCGTTTGAACCCGGGAGGC
GGAGGTTGCAGTGAGTGGAGATCGTGCCTGTGTGCTCCAGCCTGAGCAACAAGAGCGAAACTGTCTCAAAAAAAAGAAGAAAATAAATAA
ATAAAAATCAGAGCACAAGAAGTACCAGTCCACCAACTCACATTTTCTATATTAATAATTCTTAACTAAAAGAAGTTCCATATTCGACAG
CATTTTAGTTTTTTAATAGTACTTATTAGCATCAACCATCTTGATAATCACCAAGGGAAAAATTAAAAATACCTAGACTGCAATAAACCT
TTAAATTGGATTTTCAGTGAGAATTTAGAAGCAATCACTACCTTTCTCGTTTCATTTGTGTAACCATGCAGCATAGGCACTGTGTTACAT
CATCTTTACGCTTTGGTATTTGAACTTATTACAGAATTTTTTCTCTAAATTGGATGTTTCTTTATATGACCTTGGAAACTGAAGTGATCT

>37002_37002_4_HNF1B-ANAPC16_HNF1B_chr17_36091586_ENST00000561193_ANAPC16_chr10_73990124_ENST00000299381_length(amino acids)=385AA_BP=322
MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPP
ILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIL
RQFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRV
YNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSDGSERFLCESVFSYQVASTLKQVKHDQQVARMEKLAGL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HNF1B-ANAPC16

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for HNF1B-ANAPC16

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for HNF1B-ANAPC16

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source