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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HNRNPA2B1-ETV1 (FusionGDB2 ID:37073)

Fusion Gene Summary for HNRNPA2B1-ETV1

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPA2B1-ETV1
Fusion gene ID: 37073
HgeneTgene
Gene symbol

HNRNPA2B1

ETV1

Gene ID

3181

2115

Gene nameheterogeneous nuclear ribonucleoprotein A2/B1ETS variant transcription factor 1
SynonymsHNRNPA2|HNRNPB1|HNRPA2|HNRPA2B1|HNRPB1|IBMPFD2|RNPA2|SNRPB1ER81
Cytomap

7p15.2

7p21.2

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B1/MYC fusionepididymis secretory sperm binding proteinhnRNP A2 / hnRNP B1nuclear ribonucleoprotein particle A2 proteinETS translocation variant 1ETS variant 1ets variant gene 1ets-related protein 81
Modification date2020031420200313
UniProtAcc

P22626

P50549

Ensembl transtripts involved in fusion geneENST00000354667, ENST00000356674, 
ENST00000476233, 		ENST00000242066, 
ENST00000343495, ENST00000399357, 
ENST00000403527, ENST00000403685, 
ENST00000405192, ENST00000405218, 
ENST00000405358, ENST00000420159, 
ENST00000430479, ENST00000476720, 
Fusion gene scores* DoF score43 X 37 X 14=2227413 X 27 X 6=2106
# samples 5030
** MAII scorelog2(50/22274*10)=-5.47728875772656
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/2106*10)=-2.81147103052984
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HNRNPA2B1 [Title/Abstract] AND ETV1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHNRNPA2B1(26240192)-ETV1(14027800), # samples:6
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHNRNPA2B1

GO:0006397

mRNA processing

2557628

HgeneHNRNPA2B1

GO:0006406

mRNA export from nucleus

10567417

HgeneHNRNPA2B1

GO:0031053

primary miRNA processing

26321680

HgeneHNRNPA2B1

GO:0050658

RNA transport

17004321

HgeneHNRNPA2B1

GO:1990428

miRNA transport

24356509

TgeneETV1

GO:0045944

positive regulation of transcription by RNA polymerase II

12750007


check buttonFusion gene breakpoints across HNRNPA2B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ETV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4adenocarcinomaEF632110HNRNPA2B1chr7

26240366

ETV1chr7

13978820
ChimerKB3..HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
ChimerKB3..HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
ChimerKB3..HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
ChiTaRS5.0N/AEF632110HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
ChiTaRS5.0N/AFW581621HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
ChiTaRS5.0N/AHZ416115HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
ChiTaRS5.0N/AJB772362HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
ChiTaRS5.0N/ALV708919HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
ChiTaRS5.0N/AMA648833HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-


Top

Fusion Gene ORF analysis for HNRNPA2B1-ETV1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000354667ENST00000242066HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000354667ENST00000242066HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000354667ENST00000343495HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000354667ENST00000343495HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000354667ENST00000399357HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000354667ENST00000399357HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000354667ENST00000403527HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000354667ENST00000403527HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000354667ENST00000403685HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000354667ENST00000403685HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000354667ENST00000405192HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000354667ENST00000405192HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000354667ENST00000405218HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000354667ENST00000405218HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000354667ENST00000405358HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000354667ENST00000405358HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000354667ENST00000420159HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000354667ENST00000420159HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000354667ENST00000430479HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000354667ENST00000476720HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000354667ENST00000476720HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000356674ENST00000242066HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000356674ENST00000242066HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000356674ENST00000343495HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000356674ENST00000343495HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000356674ENST00000399357HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000356674ENST00000399357HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000356674ENST00000403527HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000356674ENST00000403527HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000356674ENST00000403685HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000356674ENST00000403685HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000356674ENST00000405192HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000356674ENST00000405192HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000356674ENST00000405218HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000356674ENST00000405218HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000356674ENST00000405358HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000356674ENST00000405358HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000356674ENST00000420159HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000356674ENST00000420159HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
5CDS-intronENST00000356674ENST00000430479HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000356674ENST00000476720HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
5CDS-intronENST00000356674ENST00000476720HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
In-frameENST00000354667ENST00000430479HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
In-frameENST00000356674ENST00000430479HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
intron-3CDSENST00000354667ENST00000242066HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000354667ENST00000242066HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000354667ENST00000343495HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000354667ENST00000343495HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000354667ENST00000399357HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000354667ENST00000399357HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000354667ENST00000403527HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000354667ENST00000403527HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000354667ENST00000403685HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000354667ENST00000403685HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000354667ENST00000405192HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000354667ENST00000405192HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000354667ENST00000405218HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000354667ENST00000405218HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000354667ENST00000405358HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000354667ENST00000405358HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000354667ENST00000420159HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000354667ENST00000420159HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000354667ENST00000430479HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000354667ENST00000430479HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000356674ENST00000242066HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000356674ENST00000242066HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000356674ENST00000343495HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000356674ENST00000343495HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000356674ENST00000399357HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000356674ENST00000399357HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000356674ENST00000403527HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000356674ENST00000403527HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000356674ENST00000403685HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000356674ENST00000403685HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000356674ENST00000405192HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000356674ENST00000405192HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000356674ENST00000405218HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000356674ENST00000405218HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000356674ENST00000405358HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000356674ENST00000405358HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000356674ENST00000420159HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000356674ENST00000420159HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000356674ENST00000430479HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000356674ENST00000430479HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000476233ENST00000242066HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000476233ENST00000242066HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000476233ENST00000343495HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000476233ENST00000343495HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000476233ENST00000399357HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000476233ENST00000399357HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000476233ENST00000403527HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000476233ENST00000403527HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000476233ENST00000403685HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000476233ENST00000403685HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000476233ENST00000405192HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000476233ENST00000405192HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000476233ENST00000405218HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000476233ENST00000405218HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000476233ENST00000405358HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000476233ENST00000405358HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000476233ENST00000420159HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000476233ENST00000420159HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000476233ENST00000430479HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-3CDSENST00000476233ENST00000430479HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-3CDSENST00000476233ENST00000430479HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
intron-5UTRENST00000354667ENST00000476720HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-5UTRENST00000354667ENST00000476720HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-5UTRENST00000356674ENST00000476720HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-5UTRENST00000356674ENST00000476720HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-5UTRENST00000476233ENST00000476720HNRNPA2B1chr7

26240366

ETV1chr7

13978820

intron-5UTRENST00000476233ENST00000476720HNRNPA2B1chr7

26240366

-ETV1chr7

13978820

-
intron-intronENST00000354667ENST00000242066HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000354667ENST00000343495HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000354667ENST00000399357HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000354667ENST00000403527HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000354667ENST00000403685HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000354667ENST00000405192HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000354667ENST00000405218HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000354667ENST00000405358HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000354667ENST00000420159HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000354667ENST00000430479HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000354667ENST00000476720HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000356674ENST00000242066HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000356674ENST00000343495HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000356674ENST00000399357HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000356674ENST00000403527HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000356674ENST00000403685HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000356674ENST00000405192HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000356674ENST00000405218HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000356674ENST00000405358HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000356674ENST00000420159HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000356674ENST00000430479HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000356674ENST00000476720HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000476233ENST00000242066HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000476233ENST00000242066HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
intron-intronENST00000476233ENST00000242066HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
intron-intronENST00000476233ENST00000343495HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000476233ENST00000343495HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
intron-intronENST00000476233ENST00000343495HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
intron-intronENST00000476233ENST00000399357HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000476233ENST00000399357HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
intron-intronENST00000476233ENST00000399357HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
intron-intronENST00000476233ENST00000403527HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000476233ENST00000403527HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
intron-intronENST00000476233ENST00000403527HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
intron-intronENST00000476233ENST00000403685HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000476233ENST00000403685HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
intron-intronENST00000476233ENST00000403685HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
intron-intronENST00000476233ENST00000405192HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000476233ENST00000405192HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
intron-intronENST00000476233ENST00000405192HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
intron-intronENST00000476233ENST00000405218HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000476233ENST00000405218HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
intron-intronENST00000476233ENST00000405218HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
intron-intronENST00000476233ENST00000405358HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000476233ENST00000405358HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
intron-intronENST00000476233ENST00000405358HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
intron-intronENST00000476233ENST00000420159HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000476233ENST00000420159HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
intron-intronENST00000476233ENST00000420159HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-
intron-intronENST00000476233ENST00000430479HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000476233ENST00000430479HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
intron-intronENST00000476233ENST00000476720HNRNPA2B1chr7

26206891

-ETV1chr7

13945344

-
intron-intronENST00000476233ENST00000476720HNRNPA2B1chr7

26240191

-ETV1chr7

14029642

-
intron-intronENST00000476233ENST00000476720HNRNPA2B1chr7

26240192

-ETV1chr7

14027800

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354667HNRNPA2B1chr726240192-ENST00000430479ETV1chr714027800-62021751691563464
ENST00000356674HNRNPA2B1chr726240192-ENST00000430479ETV1chr714027800-62021751691563464

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354667ENST00000430479HNRNPA2B1chr726240192-ETV1chr714027800-0.0003982770.9996018
ENST00000356674ENST00000430479HNRNPA2B1chr726240192-ETV1chr714027800-0.0003982770.9996018

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Fusion Genomic Features for HNRNPA2B1-ETV1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HNRNPA2B1-ETV1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:26240192/chr7:14027800)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPA2B1

P22626

ETV1

P50549

FUNCTION: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays also a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}.FUNCTION: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneETV1chr7:26240192chr7:14027800ENST00000242066213335_41515460.0DNA bindingETS
TgeneETV1chr7:26240192chr7:14027800ENST00000343495213335_41515460.0DNA bindingETS
TgeneETV1chr7:26240192chr7:14027800ENST0000039935709335_4150375.0DNA bindingETS
TgeneETV1chr7:26240192chr7:14027800ENST00000403527010335_4150438.0DNA bindingETS
TgeneETV1chr7:26240192chr7:14027800ENST00000403685112335_41515460.0DNA bindingETS
TgeneETV1chr7:26240192chr7:14027800ENST00000405192112335_41515455.0DNA bindingETS
TgeneETV1chr7:26240192chr7:14027800ENST00000405218113335_41515478.0DNA bindingETS
TgeneETV1chr7:26240192chr7:14027800ENST0000042015909335_4150420.0DNA bindingETS
TgeneETV1chr7:26240192chr7:14027800ENST00000430479214335_41515478.0DNA bindingETS

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPA2B1chr7:26240192chr7:14027800ENST00000354667-112202_35321115.3333333333333Compositional biasNote=Gly-rich
HgeneHNRNPA2B1chr7:26240192chr7:14027800ENST00000356674-111202_3532439.3333333333333Compositional biasNote=Gly-rich
HgeneHNRNPA2B1chr7:26240192chr7:14027800ENST00000354667-112112_19121115.3333333333333DomainRRM 2
HgeneHNRNPA2B1chr7:26240192chr7:14027800ENST00000354667-11221_10421115.3333333333333DomainRRM 1
HgeneHNRNPA2B1chr7:26240192chr7:14027800ENST00000356674-111112_1912439.3333333333333DomainRRM 2
HgeneHNRNPA2B1chr7:26240192chr7:14027800ENST00000356674-11121_1042439.3333333333333DomainRRM 1
HgeneHNRNPA2B1chr7:26240192chr7:14027800ENST00000354667-1129_1521115.3333333333333MotifNuclear localization signal
HgeneHNRNPA2B1chr7:26240192chr7:14027800ENST00000356674-1119_152439.3333333333333MotifNuclear localization signal
HgeneHNRNPA2B1chr7:26240192chr7:14027800ENST00000354667-112193_35321115.3333333333333RegionLow complexity (LC) region
HgeneHNRNPA2B1chr7:26240192chr7:14027800ENST00000354667-112308_34721115.3333333333333RegionNuclear targeting sequence
HgeneHNRNPA2B1chr7:26240192chr7:14027800ENST00000356674-111193_3532439.3333333333333RegionLow complexity (LC) region
HgeneHNRNPA2B1chr7:26240192chr7:14027800ENST00000356674-111308_3472439.3333333333333RegionNuclear targeting sequence


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Fusion Gene Sequence for HNRNPA2B1-ETV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37073_37073_1_HNRNPA2B1-ETV1_HNRNPA2B1_chr7_26240192_ENST00000354667_ETV1_chr7_14027800_ENST00000430479_length(transcript)=6202nt_BP=175nt
AGTAGCAGCAGCGCCGGGTCCCGTGCGGAGGTGCTCCTCGCAGAGTTGTTTCTCGAGCAGCGGCAGTTCTCACTACAGCGCCAGGACGAG
TCCGGTTCGTGTTCGTCCGCGGAGATCTCTCTCATCTCGCTCGGCTGCGGGAAATCGGGCTGAAGCGACTGAGTCCGCGATGGAGAGTCA
GCGTGGGAGAAATTGTAACGAGAAACCAACAAATGTCAGGAAAAGAAAATTCATTAACAGAGATCTGGCTCATGATTCAGAAGAACTCTT
TCAAGATCTAAGTCAATTACAGGAAACATGGCTTGCAGAAGCTCAGGTACCTGACAATGATGAGCAGTTTGTACCAGACTATCAGGCTGA
AAGTTTGGCTTTTCATGGCCTGCCACTGAAAATCAAGAAAGAACCCCACAGTCCATGTTCAGAAATCAGCTCTGCCTGCAGTCAAGAACA
GCCCTTTAAATTCAGCTATGGAGAAAAGTGCCTGTACAATGTCAGTGCCTATGATCAGAAGCCACAAGTGGGAATGAGGCCCTCCAACCC
CCCCACACCATCCAGCACGCCAGTGTCCCCACTGCATCATGCATCTCCAAACTCAACTCATACACCGAAACCTGACCGGGCCTTCCCAGC
TCACCTCCCTCCATCGCAGTCCATACCAGATAGCAGCTACCCCATGGACCACAGATTTCGCCGCCAGCTTTCTGAACCCTGTAACTCCTT
TCCTCCTTTGCCGACGATGCCAAGGGAAGGACGTCCTATGTACCAACGCCAGATGTCTGAGCCAAACATCCCCTTCCCACCACAAGGCTT
TAAGCAGGAGTACCACGACCCAGTGTATGAACACAACACCATGGTTGGCAGTGCGGCCAGCCAAAGCTTTCCCCCTCCTCTGATGATTAA
ACAGGAACCCAGAGATTTTGCATATGACTCAGAAGTGCCTAGCTGCCACTCCATTTATATGAGGCAAGAAGGCTTCCTGGCTCATCCCAG
CAGAACAGAAGGCTGTATGTTTGAAAAGGGCCCCAGGCAGTTTTATGATGACACCTGTGTTGTCCCAGAAAAATTCGATGGAGACATCAA
ACAAGAGCCAGGAATGTATCGGGAAGGACCCACATACCAACGGCGAGGATCACTTCAGCTCTGGCAGTTTTTGGTAGCTCTTCTGGATGA
CCCTTCAAATTCTCATTTTATTGCCTGGACTGGTCGAGGCATGGAATTTAAACTGATTGAGCCTGAAGAGGTGGCCCGACGTTGGGGCAT
TCAGAAAAACAGGCCAGCTATGAACTATGATAAACTTAGCCGTTCACTCCGCTATTACTATGAGAAAGGAATTATGCAAAAGGTGGCTGG
AGAGAGATATGTCTACAAGTTTGTGTGTGATCCAGAAGCCCTTTTCTCCATGGCCTTTCCAGATAATCAGCGTCCACTGCTGAAGACAGA
CATGGAACGTCACATCAACGAGGAGGACACAGTGCCTCTTTCTCACTTTGATGAGAGCATGGCCTACATGCCGGAAGGGGGCTGCTGCAA
CCCCCACCCCTACAACGAAGGCTACGTGTATTAACACAAGTGACAGTCAAGCAGGGCGTTTTTGCGCTTTTCCTTTTTTCTGCAAGATAC
AGAGAATTGCTGAATCTTTGTTTTATTTCTGTTGTTTGTATTTTATTTTTAAATAATAATACACAAAAAGGGGCTTTTCCTGTTGCATTA
TTCTATGGTCTGCCATGGACTGTGCACTTTATTTGAGGGTGGGTGGGAGTAATCTAAACATTTATTCTGTGTAACAGGAAGCTAATGGGT
GAATGGGCAGAGGGATTTGGGGATTACTTTTTACTTAGGCTTGGGATGGGGTCCTACAAGTTTTGAGTATGATGAAACTATATCATGTCT
GTTTGATTTCATAACAACATAAGATAATGTTTATTTTATCGGGGTATCTATGGTACAGTTAATTTCACGTTGTGTAAATATCCACTTGGA
GACTATTTGCCTTGGGCATTTTCCCCTGTCATTTATGAGTCTCTGCAGGTGTACAAAAAAACCCCAATCTACTGTAAATGGCAGTTTAAT
TGTTAGAAATGACTGTTTTTGCACCACTTGTAAAAAGGTATTTAGCGATTGCATTTGCTGTTTGTTGTTTTATTTTGCTTTATATATGAC
TTGCAGAGGATAACCATAAAATGGGTAATTCTCTCTGAAGTTGAATAATCACCATGACTGTAAATGAGGGGCACAATTTTGGACTCTGGC
GCCAAACTGAGTCATAGGCCAGTAGCATTACGTGTATCTGGTGCCACCTTGCTGTTTAGATACAAATCATACCGTCTTTTAAATATTTTG
AAGCCCATTTCAGTTAAATAATGACATGTCATGGTCCTTTGGAATCTTCATTTAAATGTTAAATCTGGAATCAAAATGAAGCAAAAAATA
TCTGTCTCCTTTTCACTTTCTTCAGTACATAAATACATTATTTAATCAATAAGAATTAACTGTACTAAATCATGTATTATGCTGTTCTAG
TTACAGCAAACACTCTTTAAGAAAAATATCCAATACACTAAATAGGTACTATAGTAATTTTTAGACATGGTACCCATTGATATGCATTTA
AACCTTTTACTGCTGTGTTATGTTGATAACATATATAAATATTAGATAATGCTAATGCTTCTGCTGCTGTCTTTTCTGTAATATTCTCTT
TCATGCTGAATTTACTATGACCATTTATAAGCAGTGCAGTTAACTACAGATAGCATTTCAGGACAAAATAGATGACTCAAACCATTTATT
GCTTAAAAAATAGCTTACGCCATGCTATGCTATAAGCAGCTTTTATGCACATTGACAAATGAAGAGTAAGCTTCAGCTTGCTAAAGGAAA
CTGTGGAACCTTTTGTAACTTTTGGTGATATGGAAAATTATTTACAAACCGTCAAAGAATATGAGGAAGTTGCTGTATGACATAGTGCTG
GCACTGATATTATCCATCATCTCTTTTTGGACACTTCTGTAAATGTGATTGGATTGTTTGAAAGAAGATTTAAAGTTTCAAAGTTTTTTG
TTCTGTTTTTGCTTTGCATTTGGAGAAAATATTGAAAGCAGGGTATGTTGTTTCATTCACCTTGAAAAAACCATGAGTAAATGGGGATAT
AGAATCTCTGAATAGCTCGCTAAAAGATTCAAGCAAGGGACATGAATTTTGTTCCATCTATCAATAATATCCAGAAGAACAACTTTTTTA
AAGAGTCTATAGCAAAAAGCAAAAAAAAAAAAAAATTCTAAACACAAAGTCAAAATAAACCTATTGTAAAAGCATTTCGTGATGAGCATG
AAAAAGATTGTTTAAAGATGATCCCCCCAGCTACCCATTTTCCAAAACTACACAGATCACAGCTCATTTCTCTAAGTGGAGCAGTTATCA
AGAAACCCAAACACCAAAATTGCTACTCTTCACATTTAATCCTACAAAAAGTACTCCAATTTCAAAATATGTATGTAACCTGCGATTTCA
ATGATTGTTGTTCATATACATCATGTATTATTTTGGCCCATTTTGGGCCTAAAAAAGAAAACTATGCCTTAAAAATCAGAACCTTTTCTC
CCCACTATGCTTATGTGGCCATCTACAGCACTTAGAATAAAAACAGATGTTAAAATATTCAGTGAAAGTTTTATTGGAAAAAGGAATTGA
GATATATAATTGAGATTTGGTGAAATTGAAGGAGAAAATTTAAGTGAGTCTTTAAAATATATTCTGAATGAAAACTGTATTGAGGATTCA
TTTTTGTTCCTTTTTTTTCTTTTTCTCTTTTCTCCTTTTTCTTCTTTTTAATAGTCTAGTTTTAGTCAGTCAGTGAGGAAGAATTGGGCC
ATGCTAACGTTATCACAAGAGAACAATGGCAGAAATGGTATTAGTTATATAATATTTAAGGACAAACTATATGTTTTGCTGTTTTAACGT
AGTGACTCACTGAACTAAATACATAATTGACCAACATTAAGTGTATTTCCAATACAGAAGGGTTGAAAATATTACATTATAAACTCTTTT
GAAAAATGTATCTAAAATTTTTTAAGTTCTGTTTTGATTCCACTTTTTGGTTGAGTTTTTATGTTTTTGTTTTCAGGTAGATTAATAAAT
CTGGCAGCTGATTTCTGCAAGATTCTTGTGTTTTGAATTTCTCATTGAATTGGCTACTCAAACATAGAAATCATTTGTTAATGATGTAAT
GTCTTCTCTCAGCTTTTATCTTCACTGCTGTTTGCTGTCTCTTGATGATGACATGTTAATACCCAATAGATTAATTGCAACAAACACTTA
TACTCAAATAACTAAGTAAAAATAATTTTTCTTGTTATGTCCATGAAAAGTGCTTCAGAATAAAAATCCACAAGACTGACAGTGCAGAAC
ATTTTTCTCAAATCATGGGCGGATCTTGGAGGTCTAGTTTCCCGTAGATGCTGTAACCAATTACCACAACTTCAGTAATTTACACAAATT
TATCTTATAGTTCTGGAGGCAGAAGTTCAAAAGAAGCCTTAAGAGACTAAAACCAAGATGTCCTTAGGTCTGGTTCCTTCTGGAGGCTCC
AGGGGAGATTCTTCCAGCTTTCACTTCTAGAGTCTGCTGACATTCCTTGGCTCCTGGCTACATCACTTCAATCTCTGCTTCCATGGTCAC
ATACTCTTCTACTATAGTCAAATTTCCTTCCTGCCTCTTATAAGGATGCTTGTGATTACATTTAGGGGATGCTCAGATAATCCAGGACAA
TCTCTCCATCTCAAGATCCTTAACTTAATGACGTGTGCCAAGTCCCTTTGGCTAGATAATTATTCATAGGTCCCAGGGATTAGGACATGG
ATGTAAGGGGTGAGGGCAGGGCTGTTATTCAGAACACCGCACGGAGGAGGAAGACTGTGTAGCAAAGACTCTAATTGATTTACTCAGGAA
CAGTGGAGTTCTGCTGAGGGATCTAGGATTTGAAAGTACTAGAGTTTGCTTTTATTTACCACTGAGATATTTTCCCCTTATTCTGCATAA
ATAATTTTGAAAACTTTCTATATTAAATTTCAACTATTCCACTAAAATGTCTGGTAATCACATCAAGCCTTTAGATTATTCAAATCCTTC
CCCAGCCCCCAGGAAAACACTAAGTCATGAAACAGAAAAACAGAAGGTATGATAATAATAGTAATAACAGTTAAATCAGTGGTCTAATCC
AGATTTTATTTTTTAATACATTTCTTTTGGTGTTAATATGGGTTACTATGTGATCTTATCATTTGCTAGTGATTATTACTTATTAGGTAA
GAACAATGTGTAAAATATGTCTATTACTCAAAAGAACAATTGCAAAATGAGTCAACTTATCTTTATATAACCAGGAAAGAAATATATTGC
CAGAAGCTACAGAATTTTGCCAGATGATAGGGATTTCTAAAATGAGCCACTTTGTCTATCATGCAGCCTTTTCAGAGCTTGTAATGAGAA
AACATTACAGAGGAGAAGGTCATTTGGATGTTTGTTACTTGGAATCCTAGAAAACAAAAACTAAAATTTAAAAATAAGAAGTGAGTAAGC
TATTTTCCATTTGCGATTTGGTATGGAGAAGAGAGGAAATAGAATTATTAAAAAAATACAAATTGGGTAAAAGTGATGGTGGAAAAAATA
TAAAGAAGGCAAATGTACATATTAAGCAATTCTACTAAGAATTGGAAAAATCAAGTTTCAAAAAGATGGTAATAGTTGGGCATGATACTA
GAAAATTTCACCCAGTTTATTCAGAGCTCAACTAGTACTTTTAGGACTTCTTTTTTTATATACATGAGACTCACTTTGACATACTTAAAA
AAAAAACAGTTTATGGAAAGTACAGTTTAAGAGGAGAATTTGATTAGACTAAGTGGATATCTTTATAGAAATATTAATGATTTCAGAATT
TTCAGTTACAAGTGTATATACCGTGGCTATTGTTTATGGATTCATATGTAAGGTAGGGTCTTTTTTGCATATAGACTCCAGTATTAGTTA
CTTTCATTCTAAAATTATATTTATGCTTCTATGGGGAAGAAAATTTTTAATTCACTTGGTTGTATTAAAATTATACTTACGGTTTGAGAA

>37073_37073_1_HNRNPA2B1-ETV1_HNRNPA2B1_chr7_26240192_ENST00000354667_ETV1_chr7_14027800_ENST00000430479_length(amino acids)=464AA_BP=2
MESQRGRNCNEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSEISSAC
SQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNSTHTPKPDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEP
CNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFL
AHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVAR
RWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEG

--------------------------------------------------------------
>37073_37073_2_HNRNPA2B1-ETV1_HNRNPA2B1_chr7_26240192_ENST00000356674_ETV1_chr7_14027800_ENST00000430479_length(transcript)=6202nt_BP=175nt
AGTAGCAGCAGCGCCGGGTCCCGTGCGGAGGTGCTCCTCGCAGAGTTGTTTCTCGAGCAGCGGCAGTTCTCACTACAGCGCCAGGACGAG
TCCGGTTCGTGTTCGTCCGCGGAGATCTCTCTCATCTCGCTCGGCTGCGGGAAATCGGGCTGAAGCGACTGAGTCCGCGATGGAGAGTCA
GCGTGGGAGAAATTGTAACGAGAAACCAACAAATGTCAGGAAAAGAAAATTCATTAACAGAGATCTGGCTCATGATTCAGAAGAACTCTT
TCAAGATCTAAGTCAATTACAGGAAACATGGCTTGCAGAAGCTCAGGTACCTGACAATGATGAGCAGTTTGTACCAGACTATCAGGCTGA
AAGTTTGGCTTTTCATGGCCTGCCACTGAAAATCAAGAAAGAACCCCACAGTCCATGTTCAGAAATCAGCTCTGCCTGCAGTCAAGAACA
GCCCTTTAAATTCAGCTATGGAGAAAAGTGCCTGTACAATGTCAGTGCCTATGATCAGAAGCCACAAGTGGGAATGAGGCCCTCCAACCC
CCCCACACCATCCAGCACGCCAGTGTCCCCACTGCATCATGCATCTCCAAACTCAACTCATACACCGAAACCTGACCGGGCCTTCCCAGC
TCACCTCCCTCCATCGCAGTCCATACCAGATAGCAGCTACCCCATGGACCACAGATTTCGCCGCCAGCTTTCTGAACCCTGTAACTCCTT
TCCTCCTTTGCCGACGATGCCAAGGGAAGGACGTCCTATGTACCAACGCCAGATGTCTGAGCCAAACATCCCCTTCCCACCACAAGGCTT
TAAGCAGGAGTACCACGACCCAGTGTATGAACACAACACCATGGTTGGCAGTGCGGCCAGCCAAAGCTTTCCCCCTCCTCTGATGATTAA
ACAGGAACCCAGAGATTTTGCATATGACTCAGAAGTGCCTAGCTGCCACTCCATTTATATGAGGCAAGAAGGCTTCCTGGCTCATCCCAG
CAGAACAGAAGGCTGTATGTTTGAAAAGGGCCCCAGGCAGTTTTATGATGACACCTGTGTTGTCCCAGAAAAATTCGATGGAGACATCAA
ACAAGAGCCAGGAATGTATCGGGAAGGACCCACATACCAACGGCGAGGATCACTTCAGCTCTGGCAGTTTTTGGTAGCTCTTCTGGATGA
CCCTTCAAATTCTCATTTTATTGCCTGGACTGGTCGAGGCATGGAATTTAAACTGATTGAGCCTGAAGAGGTGGCCCGACGTTGGGGCAT
TCAGAAAAACAGGCCAGCTATGAACTATGATAAACTTAGCCGTTCACTCCGCTATTACTATGAGAAAGGAATTATGCAAAAGGTGGCTGG
AGAGAGATATGTCTACAAGTTTGTGTGTGATCCAGAAGCCCTTTTCTCCATGGCCTTTCCAGATAATCAGCGTCCACTGCTGAAGACAGA
CATGGAACGTCACATCAACGAGGAGGACACAGTGCCTCTTTCTCACTTTGATGAGAGCATGGCCTACATGCCGGAAGGGGGCTGCTGCAA
CCCCCACCCCTACAACGAAGGCTACGTGTATTAACACAAGTGACAGTCAAGCAGGGCGTTTTTGCGCTTTTCCTTTTTTCTGCAAGATAC
AGAGAATTGCTGAATCTTTGTTTTATTTCTGTTGTTTGTATTTTATTTTTAAATAATAATACACAAAAAGGGGCTTTTCCTGTTGCATTA
TTCTATGGTCTGCCATGGACTGTGCACTTTATTTGAGGGTGGGTGGGAGTAATCTAAACATTTATTCTGTGTAACAGGAAGCTAATGGGT
GAATGGGCAGAGGGATTTGGGGATTACTTTTTACTTAGGCTTGGGATGGGGTCCTACAAGTTTTGAGTATGATGAAACTATATCATGTCT
GTTTGATTTCATAACAACATAAGATAATGTTTATTTTATCGGGGTATCTATGGTACAGTTAATTTCACGTTGTGTAAATATCCACTTGGA
GACTATTTGCCTTGGGCATTTTCCCCTGTCATTTATGAGTCTCTGCAGGTGTACAAAAAAACCCCAATCTACTGTAAATGGCAGTTTAAT
TGTTAGAAATGACTGTTTTTGCACCACTTGTAAAAAGGTATTTAGCGATTGCATTTGCTGTTTGTTGTTTTATTTTGCTTTATATATGAC
TTGCAGAGGATAACCATAAAATGGGTAATTCTCTCTGAAGTTGAATAATCACCATGACTGTAAATGAGGGGCACAATTTTGGACTCTGGC
GCCAAACTGAGTCATAGGCCAGTAGCATTACGTGTATCTGGTGCCACCTTGCTGTTTAGATACAAATCATACCGTCTTTTAAATATTTTG
AAGCCCATTTCAGTTAAATAATGACATGTCATGGTCCTTTGGAATCTTCATTTAAATGTTAAATCTGGAATCAAAATGAAGCAAAAAATA
TCTGTCTCCTTTTCACTTTCTTCAGTACATAAATACATTATTTAATCAATAAGAATTAACTGTACTAAATCATGTATTATGCTGTTCTAG
TTACAGCAAACACTCTTTAAGAAAAATATCCAATACACTAAATAGGTACTATAGTAATTTTTAGACATGGTACCCATTGATATGCATTTA
AACCTTTTACTGCTGTGTTATGTTGATAACATATATAAATATTAGATAATGCTAATGCTTCTGCTGCTGTCTTTTCTGTAATATTCTCTT
TCATGCTGAATTTACTATGACCATTTATAAGCAGTGCAGTTAACTACAGATAGCATTTCAGGACAAAATAGATGACTCAAACCATTTATT
GCTTAAAAAATAGCTTACGCCATGCTATGCTATAAGCAGCTTTTATGCACATTGACAAATGAAGAGTAAGCTTCAGCTTGCTAAAGGAAA
CTGTGGAACCTTTTGTAACTTTTGGTGATATGGAAAATTATTTACAAACCGTCAAAGAATATGAGGAAGTTGCTGTATGACATAGTGCTG
GCACTGATATTATCCATCATCTCTTTTTGGACACTTCTGTAAATGTGATTGGATTGTTTGAAAGAAGATTTAAAGTTTCAAAGTTTTTTG
TTCTGTTTTTGCTTTGCATTTGGAGAAAATATTGAAAGCAGGGTATGTTGTTTCATTCACCTTGAAAAAACCATGAGTAAATGGGGATAT
AGAATCTCTGAATAGCTCGCTAAAAGATTCAAGCAAGGGACATGAATTTTGTTCCATCTATCAATAATATCCAGAAGAACAACTTTTTTA
AAGAGTCTATAGCAAAAAGCAAAAAAAAAAAAAAATTCTAAACACAAAGTCAAAATAAACCTATTGTAAAAGCATTTCGTGATGAGCATG
AAAAAGATTGTTTAAAGATGATCCCCCCAGCTACCCATTTTCCAAAACTACACAGATCACAGCTCATTTCTCTAAGTGGAGCAGTTATCA
AGAAACCCAAACACCAAAATTGCTACTCTTCACATTTAATCCTACAAAAAGTACTCCAATTTCAAAATATGTATGTAACCTGCGATTTCA
ATGATTGTTGTTCATATACATCATGTATTATTTTGGCCCATTTTGGGCCTAAAAAAGAAAACTATGCCTTAAAAATCAGAACCTTTTCTC
CCCACTATGCTTATGTGGCCATCTACAGCACTTAGAATAAAAACAGATGTTAAAATATTCAGTGAAAGTTTTATTGGAAAAAGGAATTGA
GATATATAATTGAGATTTGGTGAAATTGAAGGAGAAAATTTAAGTGAGTCTTTAAAATATATTCTGAATGAAAACTGTATTGAGGATTCA
TTTTTGTTCCTTTTTTTTCTTTTTCTCTTTTCTCCTTTTTCTTCTTTTTAATAGTCTAGTTTTAGTCAGTCAGTGAGGAAGAATTGGGCC
ATGCTAACGTTATCACAAGAGAACAATGGCAGAAATGGTATTAGTTATATAATATTTAAGGACAAACTATATGTTTTGCTGTTTTAACGT
AGTGACTCACTGAACTAAATACATAATTGACCAACATTAAGTGTATTTCCAATACAGAAGGGTTGAAAATATTACATTATAAACTCTTTT
GAAAAATGTATCTAAAATTTTTTAAGTTCTGTTTTGATTCCACTTTTTGGTTGAGTTTTTATGTTTTTGTTTTCAGGTAGATTAATAAAT
CTGGCAGCTGATTTCTGCAAGATTCTTGTGTTTTGAATTTCTCATTGAATTGGCTACTCAAACATAGAAATCATTTGTTAATGATGTAAT
GTCTTCTCTCAGCTTTTATCTTCACTGCTGTTTGCTGTCTCTTGATGATGACATGTTAATACCCAATAGATTAATTGCAACAAACACTTA
TACTCAAATAACTAAGTAAAAATAATTTTTCTTGTTATGTCCATGAAAAGTGCTTCAGAATAAAAATCCACAAGACTGACAGTGCAGAAC
ATTTTTCTCAAATCATGGGCGGATCTTGGAGGTCTAGTTTCCCGTAGATGCTGTAACCAATTACCACAACTTCAGTAATTTACACAAATT
TATCTTATAGTTCTGGAGGCAGAAGTTCAAAAGAAGCCTTAAGAGACTAAAACCAAGATGTCCTTAGGTCTGGTTCCTTCTGGAGGCTCC
AGGGGAGATTCTTCCAGCTTTCACTTCTAGAGTCTGCTGACATTCCTTGGCTCCTGGCTACATCACTTCAATCTCTGCTTCCATGGTCAC
ATACTCTTCTACTATAGTCAAATTTCCTTCCTGCCTCTTATAAGGATGCTTGTGATTACATTTAGGGGATGCTCAGATAATCCAGGACAA
TCTCTCCATCTCAAGATCCTTAACTTAATGACGTGTGCCAAGTCCCTTTGGCTAGATAATTATTCATAGGTCCCAGGGATTAGGACATGG
ATGTAAGGGGTGAGGGCAGGGCTGTTATTCAGAACACCGCACGGAGGAGGAAGACTGTGTAGCAAAGACTCTAATTGATTTACTCAGGAA
CAGTGGAGTTCTGCTGAGGGATCTAGGATTTGAAAGTACTAGAGTTTGCTTTTATTTACCACTGAGATATTTTCCCCTTATTCTGCATAA
ATAATTTTGAAAACTTTCTATATTAAATTTCAACTATTCCACTAAAATGTCTGGTAATCACATCAAGCCTTTAGATTATTCAAATCCTTC
CCCAGCCCCCAGGAAAACACTAAGTCATGAAACAGAAAAACAGAAGGTATGATAATAATAGTAATAACAGTTAAATCAGTGGTCTAATCC
AGATTTTATTTTTTAATACATTTCTTTTGGTGTTAATATGGGTTACTATGTGATCTTATCATTTGCTAGTGATTATTACTTATTAGGTAA
GAACAATGTGTAAAATATGTCTATTACTCAAAAGAACAATTGCAAAATGAGTCAACTTATCTTTATATAACCAGGAAAGAAATATATTGC
CAGAAGCTACAGAATTTTGCCAGATGATAGGGATTTCTAAAATGAGCCACTTTGTCTATCATGCAGCCTTTTCAGAGCTTGTAATGAGAA
AACATTACAGAGGAGAAGGTCATTTGGATGTTTGTTACTTGGAATCCTAGAAAACAAAAACTAAAATTTAAAAATAAGAAGTGAGTAAGC
TATTTTCCATTTGCGATTTGGTATGGAGAAGAGAGGAAATAGAATTATTAAAAAAATACAAATTGGGTAAAAGTGATGGTGGAAAAAATA
TAAAGAAGGCAAATGTACATATTAAGCAATTCTACTAAGAATTGGAAAAATCAAGTTTCAAAAAGATGGTAATAGTTGGGCATGATACTA
GAAAATTTCACCCAGTTTATTCAGAGCTCAACTAGTACTTTTAGGACTTCTTTTTTTATATACATGAGACTCACTTTGACATACTTAAAA
AAAAAACAGTTTATGGAAAGTACAGTTTAAGAGGAGAATTTGATTAGACTAAGTGGATATCTTTATAGAAATATTAATGATTTCAGAATT
TTCAGTTACAAGTGTATATACCGTGGCTATTGTTTATGGATTCATATGTAAGGTAGGGTCTTTTTTGCATATAGACTCCAGTATTAGTTA
CTTTCATTCTAAAATTATATTTATGCTTCTATGGGGAAGAAAATTTTTAATTCACTTGGTTGTATTAAAATTATACTTACGGTTTGAGAA

>37073_37073_2_HNRNPA2B1-ETV1_HNRNPA2B1_chr7_26240192_ENST00000356674_ETV1_chr7_14027800_ENST00000430479_length(amino acids)=464AA_BP=2
MESQRGRNCNEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSEISSAC
SQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNSTHTPKPDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEP
CNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFL
AHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVAR
RWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEG

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Fusion Gene PPI Analysis for HNRNPA2B1-ETV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HNRNPA2B1-ETV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HNRNPA2B1-ETV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource