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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HNRNPA2B1-SKAP2 (FusionGDB2 ID:37097)

Fusion Gene Summary for HNRNPA2B1-SKAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPA2B1-SKAP2
Fusion gene ID: 37097
HgeneTgene
Gene symbol

HNRNPA2B1

SKAP2

Gene ID

3181

8935

Gene nameheterogeneous nuclear ribonucleoprotein A2/B1src kinase associated phosphoprotein 2
SynonymsHNRNPA2|HNRNPB1|HNRPA2|HNRPA2B1|HNRPB1|IBMPFD2|RNPA2|SNRPB1PRAP|RA70|SAPS|SCAP2|SKAP-HOM|SKAP55R
Cytomap

7p15.2

7p15.2

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B1/MYC fusionepididymis secretory sperm binding proteinhnRNP A2 / hnRNP B1nuclear ribonucleoprotein particle A2 proteinsrc kinase-associated phosphoprotein 2Fyn-associated phosphoprotein SKAP55 homologuePyk2/RAFTK-associated proteinSKAP-55HOMSKAP55 homologretinoic acid-induced protein 70src family-associated phosphoprotein 2src kinase-associated phosphoprotein of 5
Modification date2020031420200313
UniProtAcc

P22626

.
Ensembl transtripts involved in fusion geneENST00000354667, ENST00000356674, 
ENST00000476233, 		ENST00000345317, 
ENST00000539623, ENST00000489977, 
Fusion gene scores* DoF score43 X 37 X 14=2227410 X 9 X 7=630
# samples 5013
** MAII scorelog2(50/22274*10)=-5.47728875772656
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HNRNPA2B1 [Title/Abstract] AND SKAP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHNRNPA2B1(26235467)-SKAP2(26729981), # samples:2
HNRNPA2B1(26232115)-SKAP2(26894509), # samples:2
Anticipated loss of major functional domain due to fusion event.HNRNPA2B1-SKAP2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
HNRNPA2B1-SKAP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HNRNPA2B1-SKAP2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHNRNPA2B1

GO:0006397

mRNA processing

2557628

HgeneHNRNPA2B1

GO:0006406

mRNA export from nucleus

10567417

HgeneHNRNPA2B1

GO:0031053

primary miRNA processing

26321680

HgeneHNRNPA2B1

GO:0050658

RNA transport

17004321

HgeneHNRNPA2B1

GO:1990428

miRNA transport

24356509


check buttonFusion gene breakpoints across HNRNPA2B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SKAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-43-2578-01AHNRNPA2B1chr7

26235467

-SKAP2chr7

26729981

-
ChimerDB4LUSCTCGA-43-2578HNRNPA2B1chr7

26235467

-SKAP2chr7

26729981

-
ChimerDB4UCECTCGA-PG-A914-01AHNRNPA2B1chr7

26232115

-SKAP2chr7

26894509

-
ChimerDB4UCECTCGA-PG-A914HNRNPA2B1chr7

26232114

-SKAP2chr7

26894509

-
ChimerDB4UCECTCGA-PG-A914HNRNPA2B1chr7

26232115

-SKAP2chr7

26894509

-
ChimerDB4UCECTCGA-PG-A914HNRNPA2B1chr7

26240192

-SKAP2chr7

26883756

-


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Fusion Gene ORF analysis for HNRNPA2B1-SKAP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000354667ENST00000345317HNRNPA2B1chr7

26232115

-SKAP2chr7

26894509

-
3UTR-3CDSENST00000354667ENST00000345317HNRNPA2B1chr7

26232114

-SKAP2chr7

26894509

-
3UTR-3CDSENST00000356674ENST00000345317HNRNPA2B1chr7

26232115

-SKAP2chr7

26894509

-
3UTR-3CDSENST00000356674ENST00000345317HNRNPA2B1chr7

26232114

-SKAP2chr7

26894509

-
3UTR-5UTRENST00000354667ENST00000539623HNRNPA2B1chr7

26232115

-SKAP2chr7

26894509

-
3UTR-5UTRENST00000354667ENST00000539623HNRNPA2B1chr7

26232114

-SKAP2chr7

26894509

-
3UTR-5UTRENST00000356674ENST00000539623HNRNPA2B1chr7

26232115

-SKAP2chr7

26894509

-
3UTR-5UTRENST00000356674ENST00000539623HNRNPA2B1chr7

26232114

-SKAP2chr7

26894509

-
3UTR-intronENST00000354667ENST00000489977HNRNPA2B1chr7

26232115

-SKAP2chr7

26894509

-
3UTR-intronENST00000354667ENST00000489977HNRNPA2B1chr7

26232114

-SKAP2chr7

26894509

-
3UTR-intronENST00000356674ENST00000489977HNRNPA2B1chr7

26232115

-SKAP2chr7

26894509

-
3UTR-intronENST00000356674ENST00000489977HNRNPA2B1chr7

26232114

-SKAP2chr7

26894509

-
5CDS-5UTRENST00000354667ENST00000489977HNRNPA2B1chr7

26235467

-SKAP2chr7

26729981

-
5CDS-5UTRENST00000354667ENST00000539623HNRNPA2B1chr7

26240192

-SKAP2chr7

26883756

-
5CDS-5UTRENST00000356674ENST00000489977HNRNPA2B1chr7

26235467

-SKAP2chr7

26729981

-
5CDS-5UTRENST00000356674ENST00000539623HNRNPA2B1chr7

26240192

-SKAP2chr7

26883756

-
5CDS-intronENST00000354667ENST00000489977HNRNPA2B1chr7

26240192

-SKAP2chr7

26883756

-
5CDS-intronENST00000356674ENST00000489977HNRNPA2B1chr7

26240192

-SKAP2chr7

26883756

-
Frame-shiftENST00000354667ENST00000345317HNRNPA2B1chr7

26240192

-SKAP2chr7

26883756

-
Frame-shiftENST00000356674ENST00000345317HNRNPA2B1chr7

26240192

-SKAP2chr7

26883756

-
In-frameENST00000354667ENST00000345317HNRNPA2B1chr7

26235467

-SKAP2chr7

26729981

-
In-frameENST00000354667ENST00000539623HNRNPA2B1chr7

26235467

-SKAP2chr7

26729981

-
In-frameENST00000356674ENST00000345317HNRNPA2B1chr7

26235467

-SKAP2chr7

26729981

-
In-frameENST00000356674ENST00000539623HNRNPA2B1chr7

26235467

-SKAP2chr7

26729981

-
intron-3CDSENST00000476233ENST00000345317HNRNPA2B1chr7

26235467

-SKAP2chr7

26729981

-
intron-3CDSENST00000476233ENST00000345317HNRNPA2B1chr7

26232115

-SKAP2chr7

26894509

-
intron-3CDSENST00000476233ENST00000345317HNRNPA2B1chr7

26232114

-SKAP2chr7

26894509

-
intron-3CDSENST00000476233ENST00000345317HNRNPA2B1chr7

26240192

-SKAP2chr7

26883756

-
intron-3CDSENST00000476233ENST00000539623HNRNPA2B1chr7

26235467

-SKAP2chr7

26729981

-
intron-5UTRENST00000476233ENST00000489977HNRNPA2B1chr7

26235467

-SKAP2chr7

26729981

-
intron-5UTRENST00000476233ENST00000539623HNRNPA2B1chr7

26232115

-SKAP2chr7

26894509

-
intron-5UTRENST00000476233ENST00000539623HNRNPA2B1chr7

26232114

-SKAP2chr7

26894509

-
intron-5UTRENST00000476233ENST00000539623HNRNPA2B1chr7

26240192

-SKAP2chr7

26883756

-
intron-intronENST00000476233ENST00000489977HNRNPA2B1chr7

26232115

-SKAP2chr7

26894509

-
intron-intronENST00000476233ENST00000489977HNRNPA2B1chr7

26232114

-SKAP2chr7

26894509

-
intron-intronENST00000476233ENST00000489977HNRNPA2B1chr7

26240192

-SKAP2chr7

26883756

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354667HNRNPA2B1chr726235467-ENST00000345317SKAP2chr726729981-38149261691209346
ENST00000354667HNRNPA2B1chr726235467-ENST00000539623SKAP2chr726729981-14479261691209346
ENST00000356674HNRNPA2B1chr726235467-ENST00000345317SKAP2chr726729981-37788901691173334
ENST00000356674HNRNPA2B1chr726235467-ENST00000539623SKAP2chr726729981-14118901691173334

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354667ENST00000345317HNRNPA2B1chr726235467-SKAP2chr726729981-0.0002723980.99972755
ENST00000354667ENST00000539623HNRNPA2B1chr726235467-SKAP2chr726729981-0.0004683840.9995316
ENST00000356674ENST00000345317HNRNPA2B1chr726235467-SKAP2chr726729981-0.0003064190.99969363
ENST00000356674ENST00000539623HNRNPA2B1chr726235467-SKAP2chr726729981-0.0005803460.9994197

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Fusion Genomic Features for HNRNPA2B1-SKAP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HNRNPA2B1-SKAP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:26235467/chr7:26729981)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPA2B1

P22626

.
FUNCTION: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays also a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPA2B1chr7:26235467chr7:26729981ENST00000354667-812112_1912521115.3333333333333DomainRRM 2
HgeneHNRNPA2B1chr7:26235467chr7:26729981ENST00000354667-81221_1042521115.3333333333333DomainRRM 1
HgeneHNRNPA2B1chr7:26235467chr7:26729981ENST00000356674-711112_191240439.3333333333333DomainRRM 2
HgeneHNRNPA2B1chr7:26235467chr7:26729981ENST00000356674-71121_104240439.3333333333333DomainRRM 1
HgeneHNRNPA2B1chr7:26235467chr7:26729981ENST00000354667-8129_152521115.3333333333333MotifNuclear localization signal
HgeneHNRNPA2B1chr7:26235467chr7:26729981ENST00000356674-7119_15240439.3333333333333MotifNuclear localization signal
TgeneSKAP2chr7:26235467chr7:26729981ENST00000345317813297_3582651096.6666666666667DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPA2B1chr7:26235467chr7:26729981ENST00000354667-812202_3532521115.3333333333333Compositional biasNote=Gly-rich
HgeneHNRNPA2B1chr7:26235467chr7:26729981ENST00000356674-711202_353240439.3333333333333Compositional biasNote=Gly-rich
HgeneHNRNPA2B1chr7:26235467chr7:26729981ENST00000354667-812193_3532521115.3333333333333RegionLow complexity (LC) region
HgeneHNRNPA2B1chr7:26235467chr7:26729981ENST00000354667-812308_3472521115.3333333333333RegionNuclear targeting sequence
HgeneHNRNPA2B1chr7:26235467chr7:26729981ENST00000356674-711193_353240439.3333333333333RegionLow complexity (LC) region
HgeneHNRNPA2B1chr7:26235467chr7:26729981ENST00000356674-711308_347240439.3333333333333RegionNuclear targeting sequence
TgeneSKAP2chr7:26235467chr7:26729981ENST00000345317813116_2192651096.6666666666667DomainPH
TgeneSKAP2chr7:26235467chr7:26729981ENST0000034531781314_642651096.6666666666667RegionHomodimerization


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Fusion Gene Sequence for HNRNPA2B1-SKAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37097_37097_1_HNRNPA2B1-SKAP2_HNRNPA2B1_chr7_26235467_ENST00000354667_SKAP2_chr7_26729981_ENST00000345317_length(transcript)=3814nt_BP=926nt
AGTAGCAGCAGCGCCGGGTCCCGTGCGGAGGTGCTCCTCGCAGAGTTGTTTCTCGAGCAGCGGCAGTTCTCACTACAGCGCCAGGACGAG
TCCGGTTCGTGTTCGTCCGCGGAGATCTCTCTCATCTCGCTCGGCTGCGGGAAATCGGGCTGAAGCGACTGAGTCCGCGATGGAGAAAAC
TTTAGAAACTGTTCCTTTGGAGAGGAAAAAGAGAGAAAAGGAACAGTTCCGTAAGCTCTTTATTGGTGGCTTAAGCTTTGAAACCACAGA
AGAAAGTTTGAGGAACTACTACGAACAATGGGGAAAGCTTACAGACTGTGTGGTAATGAGGGATCCTGCAAGCAAAAGATCAAGAGGATT
TGGTTTTGTAACTTTTTCATCCATGGCTGAGGTTGATGCTGCCATGGCTGCAAGACCTCATTCAATTGATGGGAGAGTAGTTGAGCCAAA
ACGTGCTGTAGCAAGAGAGGAATCTGGAAAACCAGGGGCTCATGTAACTGTGAAGAAGCTGTTTGTTGGCGGAATTAAAGAAGATACTGA
GGAACATCACCTTAGAGATTACTTTGAGGAATATGGAAAAATTGATACCATTGAGATAATTACTGATAGGCAGTCTGGAAAGAAAAGAGG
CTTTGGCTTTGTTACTTTTGATGACCATGATCCTGTGGATAAAATCGTATTGCAGAAATACCATACCATCAATGGTCATAATGCAGAAGT
AAGAAAGGCTTTGTCTAGACAAGAAATGCAGGAAGTTCAGAGTTCTAGGAGTGGAAGAGGAGGCAACTTTGGCTTTGGGGATTCACGTGG
TGGCGGTGGAAATTTCGGACCAGGACCAGGAAGTAACTTTAGAGGAGGATCTGATGGATATGGCAGTGGACGTGGATTTGGGGATGGCTA
TAATGGGTATGGAGGAGGACCTGGAGAAGAAGAAGAGGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGT
CCATCACACCTCAGGGGATAAGAGCACTGATTATGCTAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTC
ATTTAAGCGTGGTGATGTGATTTACATTCTTAGCAAGGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTT
GGTGCCTAAAGCCTACATAATGGAGATGTATGATATTTGAGAGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATT
TAGAAGCGTCATGAAAGCACGAGTGACAGCTCCTAACCTCTCCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTC
GCTCATTAAAATATTCCTCTGATGTGAAATTAAATGAAGGATATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTT
TGCAAAGAAATAATTATAGTTTTTATTTACCCATTTGATTTGTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAG
CATAGTATGCTACTATTGCTACTTCTGGTGTGATTTGTAATGTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATT
TCATAGCATTTTAAATTTAGTGTATCATGCGAGTTTTTTTTGGTAGATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGT
TCAAACTTTATAGATAACTTTATTGTTATTATTTATTTTCACACATTTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAA
GTTGCAAATGGCAGTGTGCTGTCACCTGCAACAGAAGTGCGTACCAGAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGG
TGCGATGATGGGCCTGGCAACATTTTCTACTGTACTTTTGTTTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTA
ACAAAATGGTATAAAGAATCTCCCAGCCAGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTG
CAGTCCCAGCTACTTGGGAGGCCAAGGCACGAGAATTGCTTGAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACT
CCAGCCTGGGCGACAGAGTGAGACTCCATCTCAGAAAAAAAAAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAA
CCAAGCACTCTCTTATCTTGCCTTATTGCTATACTATTTACATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGA
GCACTGAAAAGAAAGGAAGGGTTTGCAGAGGAGAGTGTAGAAATCCCAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAG
CCTGACATTTGAGTTATACTCTGTGCTGCCTGAGCAAGATTTGTAGAATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGT
TTAAAATACCTATGAGATACCAATGTAGCCTTAACATATGTCAAAATGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCT
AATATTGAATCATTACCTATCAGGTATTATCTTTATGGAACTTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGG
TAATATTTTAAAATCTCCATTATTTGTGTAAAACTGTTTATAAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATG
ATCATCCAATCTCAAATGTGAAAAAAAAAAAGAAATTTGATTTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTT
AAAGTTTTCAGAAGTTACATTTGTGCAGTTCTTACCTTTTCCTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAG
ACAACCAAAGACGACTTTAGTGGACTGGTTTTCAAAACTTGAGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTG
TGGATTTGGGTTTGTGCTTTGGGTTGAAAAGAAGTTTTTAGTCCTAGGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTT
GAAACCCTTCCCCCATGGCACAAACTCGCCCATGATGGAAAGCATCTAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCC
TTTGCCAACTGATGACCAACAGTTCCAAGCCAGATAGTCTCGTGAACAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCC
ACCGGCCTTTGTTCTTTTAAAACTTGAATATAGGTGGGAGACATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAA
TCATTACTTTCAATTCATGACTGCTTTATATTCATTTGATGAAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAA
TATATCACATACTCTTCAAGATCATAATAATATCATTAATATAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTC
TCATTATGTTTGCTTAGCTTTTATTTGTTTTTCTGTGAACAGTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATAT
AGCATTTTGCTTGATTATTTGCTCTGTACTGAATTTGTACTCTATTGCCATTAGATCTTACAATAATGTTCCACTCTGCAAATTTTTAAG

>37097_37097_1_HNRNPA2B1-SKAP2_HNRNPA2B1_chr7_26235467_ENST00000354667_SKAP2_chr7_26729981_ENST00000345317_length(amino acids)=346AA_BP=73
MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRV
VEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGH
NAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGEEEEDSAPVKVEEQRKMS

--------------------------------------------------------------
>37097_37097_2_HNRNPA2B1-SKAP2_HNRNPA2B1_chr7_26235467_ENST00000354667_SKAP2_chr7_26729981_ENST00000539623_length(transcript)=1447nt_BP=926nt
AGTAGCAGCAGCGCCGGGTCCCGTGCGGAGGTGCTCCTCGCAGAGTTGTTTCTCGAGCAGCGGCAGTTCTCACTACAGCGCCAGGACGAG
TCCGGTTCGTGTTCGTCCGCGGAGATCTCTCTCATCTCGCTCGGCTGCGGGAAATCGGGCTGAAGCGACTGAGTCCGCGATGGAGAAAAC
TTTAGAAACTGTTCCTTTGGAGAGGAAAAAGAGAGAAAAGGAACAGTTCCGTAAGCTCTTTATTGGTGGCTTAAGCTTTGAAACCACAGA
AGAAAGTTTGAGGAACTACTACGAACAATGGGGAAAGCTTACAGACTGTGTGGTAATGAGGGATCCTGCAAGCAAAAGATCAAGAGGATT
TGGTTTTGTAACTTTTTCATCCATGGCTGAGGTTGATGCTGCCATGGCTGCAAGACCTCATTCAATTGATGGGAGAGTAGTTGAGCCAAA
ACGTGCTGTAGCAAGAGAGGAATCTGGAAAACCAGGGGCTCATGTAACTGTGAAGAAGCTGTTTGTTGGCGGAATTAAAGAAGATACTGA
GGAACATCACCTTAGAGATTACTTTGAGGAATATGGAAAAATTGATACCATTGAGATAATTACTGATAGGCAGTCTGGAAAGAAAAGAGG
CTTTGGCTTTGTTACTTTTGATGACCATGATCCTGTGGATAAAATCGTATTGCAGAAATACCATACCATCAATGGTCATAATGCAGAAGT
AAGAAAGGCTTTGTCTAGACAAGAAATGCAGGAAGTTCAGAGTTCTAGGAGTGGAAGAGGAGGCAACTTTGGCTTTGGGGATTCACGTGG
TGGCGGTGGAAATTTCGGACCAGGACCAGGAAGTAACTTTAGAGGAGGATCTGATGGATATGGCAGTGGACGTGGATTTGGGGATGGCTA
TAATGGGTATGGAGGAGGACCTGGAGAAGAAGAAGAGGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGT
CCATCACACCTCAGGGGATAAGAGCACTGATTATGCTAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTC
ATTTAAGCGTGGTGATGTGATTTACATTCTTAGCAAGGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTT
GGTGCCTAAAGCCTACATAATGGAGATGTATGATATTTGAGAGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATT
TAGAAGCGTCATGAAAGCACGAGTGACAGCTCCTAACCTCTCCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTC
GCTCATTAAAATATTCCTCTGATGTGAAATTAAATGAAGGATATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTT

>37097_37097_2_HNRNPA2B1-SKAP2_HNRNPA2B1_chr7_26235467_ENST00000354667_SKAP2_chr7_26729981_ENST00000539623_length(amino acids)=346AA_BP=73
MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRV
VEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGH
NAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGEEEEDSAPVKVEEQRKMS

--------------------------------------------------------------
>37097_37097_3_HNRNPA2B1-SKAP2_HNRNPA2B1_chr7_26235467_ENST00000356674_SKAP2_chr7_26729981_ENST00000345317_length(transcript)=3778nt_BP=890nt
AGTAGCAGCAGCGCCGGGTCCCGTGCGGAGGTGCTCCTCGCAGAGTTGTTTCTCGAGCAGCGGCAGTTCTCACTACAGCGCCAGGACGAG
TCCGGTTCGTGTTCGTCCGCGGAGATCTCTCTCATCTCGCTCGGCTGCGGGAAATCGGGCTGAAGCGACTGAGTCCGCGATGGAGAGAGA
AAAGGAACAGTTCCGTAAGCTCTTTATTGGTGGCTTAAGCTTTGAAACCACAGAAGAAAGTTTGAGGAACTACTACGAACAATGGGGAAA
GCTTACAGACTGTGTGGTAATGAGGGATCCTGCAAGCAAAAGATCAAGAGGATTTGGTTTTGTAACTTTTTCATCCATGGCTGAGGTTGA
TGCTGCCATGGCTGCAAGACCTCATTCAATTGATGGGAGAGTAGTTGAGCCAAAACGTGCTGTAGCAAGAGAGGAATCTGGAAAACCAGG
GGCTCATGTAACTGTGAAGAAGCTGTTTGTTGGCGGAATTAAAGAAGATACTGAGGAACATCACCTTAGAGATTACTTTGAGGAATATGG
AAAAATTGATACCATTGAGATAATTACTGATAGGCAGTCTGGAAAGAAAAGAGGCTTTGGCTTTGTTACTTTTGATGACCATGATCCTGT
GGATAAAATCGTATTGCAGAAATACCATACCATCAATGGTCATAATGCAGAAGTAAGAAAGGCTTTGTCTAGACAAGAAATGCAGGAAGT
TCAGAGTTCTAGGAGTGGAAGAGGAGGCAACTTTGGCTTTGGGGATTCACGTGGTGGCGGTGGAAATTTCGGACCAGGACCAGGAAGTAA
CTTTAGAGGAGGATCTGATGGATATGGCAGTGGACGTGGATTTGGGGATGGCTATAATGGGTATGGAGGAGGACCTGGAGAAGAAGAAGA
GGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACTGATTATGC
TAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATTCTTAGCAA
GGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATGTATGATAT
TTGAGAGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCATGAAAGCACGAGTGACAGCTCCTAA
CCTCTCCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAATATTCCTCTGATGTGAAATTAAATG
AAGGATATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAATAATTATAGTTTTTATTTACCCATTT
GATTTGTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAGCATAGTATGCTACTATTGCTACTTCTGGTGTGATTT
GTAATGTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATTTCATAGCATTTTAAATTTAGTGTATCATGCGAGTTT
TTTTTGGTAGATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGTTCAAACTTTATAGATAACTTTATTGTTATTATTTAT
TTTCACACATTTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGGCAGTGTGCTGTCACCTGCAACAGAA
GTGCGTACCAGAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGGGCCTGGCAACATTTTCTACTGTACT
TTTGTTTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTATAAAGAATCTCCCAGCCAGGCCAAC
ATGGTGAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCTACTTGGGAGGCCAAGGCACGAGAAT
TGCTTGAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAGAA
AAAAAAAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAACCAAGCACTCTCTTATCTTGCCTTATTGCTATACTA
TTTACATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGAGCACTGAAAAGAAAGGAAGGGTTTGCAGAGGAGAGT
GTAGAAATCCCAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAGCCTGACATTTGAGTTATACTCTGTGCTGCCTGAGCA
AGATTTGTAGAATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCTATGAGATACCAATGTAGCCTTAACA
TATGTCAAAATGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATCATTACCTATCAGGTATTATCTTTAT
GGAACTTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAAAATCTCCATTATTTGTGTAAAACTG
TTTATAAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATCTCAAATGTGAAAAAAAAAAAGAAAT
TTGATTTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCAGAAGTTACATTTGTGCAGTTCTTACC
TTTTCCTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAGACAACCAAAGACGACTTTAGTGGACTGGTTTTCAAA
ACTTGAGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTGTGGATTTGGGTTTGTGCTTTGGGTTGAAAAGAAGTT
TTTAGTCCTAGGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTTGAAACCCTTCCCCCATGGCACAAACTCGCCCATGAT
GGAAAGCATCTAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTGATGACCAACAGTTCCAAGCCAGATA
GTCTCGTGAACAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTGTTCTTTTAAAACTTGAATATAGGTG
GGAGACATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTCAATTCATGACTGCTTTATATTCATT
TGATGAAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATACTCTTCAAGATCATAATAATATCAT
TAATATAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTTTGCTTAGCTTTTATTTGTTTTTCTGT
GAACAGTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATATAGCATTTTGCTTGATTATTTGCTCTGTACTGAATTT

>37097_37097_3_HNRNPA2B1-SKAP2_HNRNPA2B1_chr7_26235467_ENST00000356674_SKAP2_chr7_26729981_ENST00000345317_length(amino acids)=334AA_BP=61
MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREES
GKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQE
MQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGEEEEDSAPVKVEEQRKMSQDSVHHTSGDKS

--------------------------------------------------------------
>37097_37097_4_HNRNPA2B1-SKAP2_HNRNPA2B1_chr7_26235467_ENST00000356674_SKAP2_chr7_26729981_ENST00000539623_length(transcript)=1411nt_BP=890nt
AGTAGCAGCAGCGCCGGGTCCCGTGCGGAGGTGCTCCTCGCAGAGTTGTTTCTCGAGCAGCGGCAGTTCTCACTACAGCGCCAGGACGAG
TCCGGTTCGTGTTCGTCCGCGGAGATCTCTCTCATCTCGCTCGGCTGCGGGAAATCGGGCTGAAGCGACTGAGTCCGCGATGGAGAGAGA
AAAGGAACAGTTCCGTAAGCTCTTTATTGGTGGCTTAAGCTTTGAAACCACAGAAGAAAGTTTGAGGAACTACTACGAACAATGGGGAAA
GCTTACAGACTGTGTGGTAATGAGGGATCCTGCAAGCAAAAGATCAAGAGGATTTGGTTTTGTAACTTTTTCATCCATGGCTGAGGTTGA
TGCTGCCATGGCTGCAAGACCTCATTCAATTGATGGGAGAGTAGTTGAGCCAAAACGTGCTGTAGCAAGAGAGGAATCTGGAAAACCAGG
GGCTCATGTAACTGTGAAGAAGCTGTTTGTTGGCGGAATTAAAGAAGATACTGAGGAACATCACCTTAGAGATTACTTTGAGGAATATGG
AAAAATTGATACCATTGAGATAATTACTGATAGGCAGTCTGGAAAGAAAAGAGGCTTTGGCTTTGTTACTTTTGATGACCATGATCCTGT
GGATAAAATCGTATTGCAGAAATACCATACCATCAATGGTCATAATGCAGAAGTAAGAAAGGCTTTGTCTAGACAAGAAATGCAGGAAGT
TCAGAGTTCTAGGAGTGGAAGAGGAGGCAACTTTGGCTTTGGGGATTCACGTGGTGGCGGTGGAAATTTCGGACCAGGACCAGGAAGTAA
CTTTAGAGGAGGATCTGATGGATATGGCAGTGGACGTGGATTTGGGGATGGCTATAATGGGTATGGAGGAGGACCTGGAGAAGAAGAAGA
GGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACTGATTATGC
TAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATTCTTAGCAA
GGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATGTATGATAT
TTGAGAGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCATGAAAGCACGAGTGACAGCTCCTAA
CCTCTCCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAATATTCCTCTGATGTGAAATTAAATG

>37097_37097_4_HNRNPA2B1-SKAP2_HNRNPA2B1_chr7_26235467_ENST00000356674_SKAP2_chr7_26729981_ENST00000539623_length(amino acids)=334AA_BP=61
MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREES
GKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQE
MQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGEEEEDSAPVKVEEQRKMSQDSVHHTSGDKS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HNRNPA2B1-SKAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HNRNPA2B1-SKAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HNRNPA2B1-SKAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource