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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HNRNPC-MGA (FusionGDB2 ID:37134)

Fusion Gene Summary for HNRNPC-MGA

Fusion gene summary

Fusion gene information	Fusion gene name: HNRNPC-MGA
	Fusion gene ID: 37134
		Hgene	Tgene
	Gene symbol	HNRNPC	MGA
	Gene ID	3183	23269
	Gene name	heterogeneous nuclear ribonucleoprotein C	MAX dimerization protein MGA
	Synonyms	C1\|C2\|HNRNP\|HNRPC\|SNRPC	MAD5\|MXD5
	Cytomap	14q11.2	15q15.1
	Type of gene	protein-coding	protein-coding
	Description	heterogeneous nuclear ribonucleoproteins C1/C2heterogeneous nuclear ribonucleoprotein C (C1/C2)hnRNP C1/C2nuclear ribonucleoprotein particle C1 proteinnuclear ribonucleoprotein particle C2 protein	MAX gene-associated proteinMAX dimerization protein 5MGA, MAX dimerization protein
	Modification date	20200322	20200313
	UniProtAcc	P07910	Q3V5L5
	Ensembl transtripts involved in fusion gene	ENST00000320084, ENST00000336053, ENST00000420743, ENST00000430246, ENST00000449098, ENST00000553300, ENST00000553753, ENST00000554455, ENST00000554969, ENST00000555309, ENST00000555883, ENST00000555914, ENST00000556142, ENST00000556513, ENST00000556628, ENST00000556897, ENST00000557201,	ENST00000219905, ENST00000389936, ENST00000545763, ENST00000566586, ENST00000570161, ENST00000568630,
Fusion gene scores	* DoF score	20 X 19 X 10=3800	6 X 7 X 3=126
	# samples	26	7
	** MAII score	log2(26/3800*10)=-3.86941589018986 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HNRNPC [Title/Abstract] AND MGA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HNRNPC(21678190)-MGA(42059993), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across HNRNPC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MGA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BI021638	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-

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Fusion Gene ORF analysis for HNRNPC-MGA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000320084	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000320084	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000320084	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000320084	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000320084	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000336053	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000336053	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000336053	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000336053	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000336053	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000420743	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000420743	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000420743	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000420743	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000420743	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000430246	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000430246	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000430246	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000430246	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000430246	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000449098	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000449098	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000449098	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000449098	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000449098	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000553300	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000553300	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000553300	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000553300	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000553300	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000553753	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000553753	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000553753	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000553753	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000553753	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000554455	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000554455	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000554455	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000554455	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000554455	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000554969	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000554969	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000554969	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000554969	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000554969	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555309	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555309	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555309	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555309	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555309	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555883	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555883	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555883	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555883	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555883	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555914	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555914	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555914	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555914	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000555914	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556142	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556142	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556142	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556142	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556142	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556513	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556513	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556513	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556513	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556513	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556628	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556628	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556628	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556628	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556628	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556897	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556897	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556897	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556897	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000556897	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000557201	ENST00000219905	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000557201	ENST00000389936	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000557201	ENST00000545763	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000557201	ENST00000566586	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-3UTR	ENST00000557201	ENST00000570161	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000320084	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000336053	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000420743	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000430246	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000449098	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000553300	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000553753	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000554455	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000554969	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000555309	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000555883	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000555914	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000556142	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000556513	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000556628	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000556897	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-
intron-intron	ENST00000557201	ENST00000568630	HNRNPC	chr14	21678190	-	MGA	chr15	42059993	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for HNRNPC-MGA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HNRNPC-MGA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21678190/:42059993)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HNRNPC P07910	MGA Q3V5L5
FUNCTION: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269\|PubMed:12509468, ECO:0000269\|PubMed:16010978, ECO:0000269\|PubMed:25719671, ECO:0000269\|PubMed:7567451, ECO:0000269\|PubMed:8264621}.	FUNCTION: Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. {ECO:0000269\|PubMed:12941944, ECO:0000269\|PubMed:14617637, ECO:0000269\|PubMed:14623122, ECO:0000269\|PubMed:16606368, ECO:0000269\|PubMed:16857188, ECO:0000269\|PubMed:19846580}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HNRNPC-MGA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HNRNPC-MGA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HNRNPC-MGA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HNRNPC-MGA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source