FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:HNRNPC-WRN (FusionGDB2 ID:37144)

Fusion Gene Summary for HNRNPC-WRN

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPC-WRN
Fusion gene ID: 37144
HgeneTgene
Gene symbol

HNRNPC

WRN

Gene ID

3183

7486

Gene nameheterogeneous nuclear ribonucleoprotein CWRN RecQ like helicase
SynonymsC1|C2|HNRNP|HNRPC|SNRPCRECQ3|RECQL2|RECQL3
Cytomap

14q11.2

8p12

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoproteins C1/C2heterogeneous nuclear ribonucleoprotein C (C1/C2)hnRNP C1/C2nuclear ribonucleoprotein particle C1 proteinnuclear ribonucleoprotein particle C2 proteinWerner syndrome ATP-dependent helicaseDNA helicase, RecQ-like type 3Werner syndrome RecQ like helicaseWerner syndrome, RecQ helicase-likeexonuclease WRNrecQ protein-like 2
Modification date2020032220200320
UniProtAcc

P07910

.
Ensembl transtripts involved in fusion geneENST00000336053, ENST00000420743, 
ENST00000449098, ENST00000553300, 
ENST00000553753, ENST00000554455, 
ENST00000554969, ENST00000555309, 
ENST00000555883, ENST00000555914, 
ENST00000556142, ENST00000556513, 
ENST00000556628, ENST00000557201, 
ENST00000320084, ENST00000430246, 
ENST00000556897, 		ENST00000298139, 
Fusion gene scores* DoF score20 X 19 X 10=38009 X 10 X 7=630
# samples 2611
** MAII scorelog2(26/3800*10)=-3.86941589018986
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HNRNPC [Title/Abstract] AND WRN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHNRNPC(21698478)-WRN(31030511), # samples:2
Anticipated loss of major functional domain due to fusion event.HNRNPC-WRN seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HNRNPC-WRN seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWRN

GO:0000731

DNA synthesis involved in DNA repair

17563354

TgeneWRN

GO:0006259

DNA metabolic process

16622405

TgeneWRN

GO:0006284

base-excision repair

17611195

TgeneWRN

GO:0006974

cellular response to DNA damage stimulus

18203716

TgeneWRN

GO:0006979

response to oxidative stress

17611195

TgeneWRN

GO:0009267

cellular response to starvation

11420665

TgeneWRN

GO:0010225

response to UV-C

17563354

TgeneWRN

GO:0031297

replication fork processing

17115688

TgeneWRN

GO:0032508

DNA duplex unwinding

11735402|26420422

TgeneWRN

GO:0044806

G-quadruplex DNA unwinding

11735402

TgeneWRN

GO:0051345

positive regulation of hydrolase activity

17611195

TgeneWRN

GO:0061820

telomeric D-loop disassembly

15200954|19734539|26420422

TgeneWRN

GO:0071480

cellular response to gamma radiation

21639834

TgeneWRN

GO:0098530

positive regulation of strand invasion

26420422

TgeneWRN

GO:1902570

protein localization to nucleolus

11420665


check buttonFusion gene breakpoints across HNRNPC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WRN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-J9-A8CK-01AHNRNPCchr14

21698478

-WRNchr8

31030511

+
ChimerDB4PRADTCGA-J9-A8CKHNRNPCchr14

21698478

-WRNchr8

31030511

+


Top

Fusion Gene ORF analysis for HNRNPC-WRN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000336053ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000420743ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000449098ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000553300ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000553753ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000554455ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000554969ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000555309ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000555883ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000555914ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000556142ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000556513ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000556628ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shiftENST00000557201ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
In-frameENST00000320084ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
In-frameENST00000430246ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
In-frameENST00000556897ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000320084HNRNPCchr1421698478-ENST00000298139WRNchr831030511+1419644240716158
ENST00000430246HNRNPCchr1421698478-ENST00000298139WRNchr831030511+4092331726063046146
ENST00000556897HNRNPCchr1421698478-ENST00000298139WRNchr831030511+1253478113550145

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000320084ENST00000298139HNRNPCchr1421698478-WRNchr831030511+0.00171740.9982827
ENST00000430246ENST00000298139HNRNPCchr1421698478-WRNchr831030511+0.0016883950.99831164
ENST00000556897ENST00000298139HNRNPCchr1421698478-WRNchr831030511+0.0023524570.9976476

Top

Fusion Genomic Features for HNRNPC-WRN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HNRNPCchr1421698477-WRNchr831030510+6.89E-060.9999931
HNRNPCchr1421698477-WRNchr831030510+6.89E-060.9999931
HNRNPCchr1421698477-WRNchr831030510+6.89E-060.9999931
HNRNPCchr1421698477-WRNchr831030510+6.89E-060.9999931

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for HNRNPC-WRN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:21698478/chr8:31030511)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPC

P07910

.
FUNCTION: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000320084-4816_87134307.0DomainRRM
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000420743-71116_87134307.0DomainRRM
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000430246-4816_87121294.0DomainRRM
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000449098-4816_87121294.0DomainRRM
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000553300-5916_87121294.0DomainRRM
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000554455-5916_87134307.0DomainRRM
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000554969-61016_87121294.0DomainRRM
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000555883-4816_87121251.0DomainRRM
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000556897-4816_87121294.0DomainRRM
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000557201-4816_87134307.0DomainRRM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000320084-48190_238134307.0Coiled coilOntology_term=ECO:0000255
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000420743-711190_238134307.0Coiled coilOntology_term=ECO:0000255
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000430246-48190_238121294.0Coiled coilOntology_term=ECO:0000255
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000449098-48190_238121294.0Coiled coilOntology_term=ECO:0000255
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000553300-59190_238121294.0Coiled coilOntology_term=ECO:0000255
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000554455-59190_238134307.0Coiled coilOntology_term=ECO:0000255
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000554969-610190_238121294.0Coiled coilOntology_term=ECO:0000255
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000555883-48190_238121251.0Coiled coilOntology_term=ECO:0000255
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000556628-48190_23854227.0Coiled coilOntology_term=ECO:0000255
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000556897-48190_238121294.0Coiled coilOntology_term=ECO:0000255
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000557201-48190_238134307.0Coiled coilOntology_term=ECO:0000255
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000320084-48181_303134307.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000420743-711181_303134307.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000430246-48181_303121294.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000449098-48181_303121294.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000553300-59181_303121294.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000554455-59181_303134307.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000554969-610181_303121294.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000555883-48181_303121251.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000556628-48181_30354227.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000556897-48181_303121294.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000557201-48181_303134307.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000556628-4816_8754227.0DomainRRM
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000320084-48155_161134307.0MotifNuclear localization signal
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000420743-711155_161134307.0MotifNuclear localization signal
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000430246-48155_161121294.0MotifNuclear localization signal
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000449098-48155_161121294.0MotifNuclear localization signal
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000553300-59155_161121294.0MotifNuclear localization signal
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000554455-59155_161134307.0MotifNuclear localization signal
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000554969-610155_161121294.0MotifNuclear localization signal
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000555883-48155_161121251.0MotifNuclear localization signal
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000556628-48155_16154227.0MotifNuclear localization signal
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000556897-48155_161121294.0MotifNuclear localization signal
HgeneHNRNPCchr14:21698478chr8:31030511ENST00000557201-48155_161134307.0MotifNuclear localization signal
TgeneWRNchr14:21698478chr8:31030511ENST000002981393335507_51013971433.0Compositional biasNote=Poly-Glu
TgeneWRNchr14:21698478chr8:31030511ENST0000029813933351150_122913971433.0DomainHRDC
TgeneWRNchr14:21698478chr8:31030511ENST000002981393335558_72413971433.0DomainHelicase ATP-binding
TgeneWRNchr14:21698478chr8:31030511ENST00000298139333560_22813971433.0DomainNote=3'-5' exonuclease
TgeneWRNchr14:21698478chr8:31030511ENST000002981393335749_89913971433.0DomainHelicase C-terminal
TgeneWRNchr14:21698478chr8:31030511ENST000002981393335668_67113971433.0MotifNote=DEAH box
TgeneWRNchr14:21698478chr8:31030511ENST000002981393335571_57813971433.0Nucleotide bindingATP
TgeneWRNchr14:21698478chr8:31030511ENST000002981393335424_47713971433.0RegionNote=2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K
TgeneWRNchr14:21698478chr8:31030511ENST000002981393335424_45013971433.0Repeat1
TgeneWRNchr14:21698478chr8:31030511ENST000002981393335451_47713971433.0Repeat2


Top

Fusion Gene Sequence for HNRNPC-WRN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37144_37144_1_HNRNPC-WRN_HNRNPC_chr14_21698478_ENST00000320084_WRN_chr8_31030511_ENST00000298139_length(transcript)=1419nt_BP=644nt
AGGAATGGGGCGGGGACTAGGCCTTCGCCTCGGCGGCAGAGGAGACTCGGGGGCCATTTTGTGAAGAGACGAAGACTGAGCGGTTGTGGC
CGCGTTGCCGACCTCCAGCAGCAGTCGGCTTCTCTACGCAGAACCCGGGAGTAGGAGACTCAGAATCGAATCTCTTCTCCCTCCCCTTCT
TGTATACTTTTTTTTGCTTTACAGTTTTCGGCTTTGTGAGAAACCTTACCATCAAACACGATGGCCAGCAACGTTACCAACAAGACAGAT
CCTCGCTCCATGAACTCCCGTGTATTCATTGGGAATCTCAACACTCTTGTGGTCAAGAAATCTGATGTGGAGGCAATCTTTTCGAAGTAT
GGCAAAATTGTGGGCTGCTCTGTTCATAAGGGCTTTGCCTTCGTTCAGTATGTTAATGAGAGAAATGCCCGGGCTGCTGTAGCAGGAGAG
GATGGCAGAATGATTGCTGGCCAGGTTTTAGATATTAACCTGGCTGCAGAGCCAAAAGTGAACCGAGGAAAAGCAGGTGTGAAACGATCT
GCAGCGGAGATGTACGGGTCAGTAACAGAACACCCTTCTCCGTCCCCTCTACTCAGCTCCTCTTTTGACTTGGACTATGACTTTCAACGG
GACTATTATGATAGACTTCATCTGCAGAGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAGCAAGAAATTAATGG
ACAAAACGAAAAGGGGAGGTCTTTTTAGTTAAGCTGGCAATTACCAGAACAATTATGTTTCTTGCTGTATTATAAGAGGATAGCTATATT
TTATTTCTGAAGAGTAAGGAGTAGTATTTTGGCTTAAAAATCATTCTAATTACAAAGTTCACTGTTTATTGAAGAACTGGCATCTTAAAT
CAGCCTTCCGCAATTCATGTAGTTTCTGGGTCTTCTGGGAGCCTACGTGAGTACATCACCTAACAGAATATTAAATTAGACTTCCTGTAA
GATTGCTTTAAGAAACTGTTACTGTCCTGTTTTCTAATCTCTTTATTAAAACAGTGTATTTGGAAAATGTTATGTGCTCTGATTTGATAT
AGATAACAGATTAGTAGTTACATGGTAATTATGTGATATAAAATATTCATATATTATCAAAATTCTGTTTTGTAAATGTAAGAAAGCATA
GTTATTTTACAAATTGTTTTTACTGTCTTTTGAAGAAGTTCTTAAATACGTTGTTAAATGGTATTAGTTGACCAGGGCAGTGAAAATGAA
ACCGCATTTTGGGTGCCATTAAATAGGGAAAAAACATGTAAAAAATGTAAAATGGAGACCAATTGCACTAGGCAAGTGTATATTTTGTAT

>37144_37144_1_HNRNPC-WRN_HNRNPC_chr14_21698478_ENST00000320084_WRN_chr8_31030511_ENST00000298139_length(amino acids)=158AA_BP=134
MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAAEPKV

--------------------------------------------------------------
>37144_37144_2_HNRNPC-WRN_HNRNPC_chr14_21698478_ENST00000430246_WRN_chr8_31030511_ENST00000298139_length(transcript)=4092nt_BP=3317nt
TTCTTGATTGAAAATGGTGCTAAAGTTGGTCTTTTTATGAGTGGTAGCTCTTCAGTTTAACATAAATAACATCTTGGGAGATACTGAGCT
TTTTGATATTGAAAGATAGAATTGGTTTCTTTTCACATTTTTCTTTATTTTTAAGCTTATGTCTTGTGGCACCTGTACAAAGGACTTGGT
TGTGGTTGAGCTATAAAGTTATGTATCTTGAAAATTGATTACCAGGTTTGGGCTGTGGCTCCAAATAAGAAAATGAAATGTTTCACCATA
ACTGTATTTCATAAACAGGAAAAGAACATTCAGATGTATATTTCTTACAATTCTTCACAAACTTTTTCCGCAATTTGTACATTCATACAG
TTTTCACACATCAAATGTAAAAATTAACTGTCATTCCTACACTGTTCTTTTTAAAAATGTATGGTACTTGTTGCTGCTGTAGTCATTCAT
GTATAGTTGGCTCAAGGAACACTTCTAAAAGCTCAATTAAAAATTTTTTTTTTGAGACAGGGTCTCTCTCTGGCCTGGCTGAAGTGCAGT
GGCGTGATCAGAGCTCACTGCAGCCTCGAACTCCTGGGCTCAAGTGATCCTCGCTCCTCAGACTGCTAAGTAGCTGGGATTTCAGGCTAC
CACACCCTGCTAATGTTTTTTGTTTTTAATAAAGTCTCGTCATGTTTCCCAGGCTGGTCTCAAACTACTGAGCTCAAGCCGTGCTCTACC
CTGGCCTCCCAAAGTGTTGGGATTACAGGTGTGAGCCACCACACTTGGCCTTAAAATATTTTAATTTCCTCAAATTTACAAAGGAGAATA
AGACCTCATGGCTAAATTGAACAGTGAGTGCAGCTAGTTCATTGTTTGCACAAGGAACTACAGTCTAATTGCAGTTCCTATTTTAGCTGA
TGAAACAACCAGTTTGTCATGGAAATTATTTTAGTGTGGTATTATGTACCAGATTTTTAGAATCCATAACTTGAAATTAGCTTTACACGC
TACATAGTAAATAGTGGACTACAGAAACAAAAGTATTAACATAAGGACCTTAATTTTTTTCACCTATTTTATGACCTTAAATATTCAGTA
TTTTTTTAATTCCATCTGTATTTTCGTTTTGTCAGTGAGTGGAATAATGTGCTCCTTATTTAAAACATCTTTTCCCCTAACAGTAGAACC
TATTAGGTCTTGTGGTTTGATCACTCACTGGTTTTGAGAATAGATGAGTCATCTCTAGTATAGATCTTCATGGTAGGCCATTCACCTTCA
GTCTATTACTCATAGCAAAAACTCCACGGACTTTTTTAAGTTTAAAACCCATGAATCTGCTTAGGTTTTATAATCTCAGTATTTGACATT
TGCTCACTATTTCATCTCTATTTGTTGGCCCGGTTTTTCTGTATTTTCTTTGCCCAAACTGCTCATTATCAAGATGAACATTTGGGATAT
ACTCTTTTTGAGACCCTCAAGGGCATATTGACATGAATTTAGTTAATTTTAGTCATCTATTGATGTTGAAGAATTGTGAAGACAGTCACT
GGTAGAGGTGATTCTATGGAGGCTATCCCATCCCAGTGGAATGTTAATGCTTTACCAAAATGTGTTAGCTGCAGTAGACAGATGTTTCTG
TCTTGGGGGTTTAGGGCACAACATTTCTGAGGAACTCTGACTCAATCTGTCCCTTCTCCTTTCACAGGGCAGCAAGGCGAACCCCATCCC
TACTCACTGGAGCTCAGCTTTGATTTTTAACCTCCCTTCCCCACCCTTCCAGAACACACACATTCCATTCCAAAACTGATTTTATAAAGA
CATTTTAAACATAATGATGCAACTTGGTGTGCACTACAGCAAATGTACAGGTGTTTTTTTTTTAATTGTTTCCAAAACCGGGACCTGGAT
TTAAGATGTAATTTTTAAAATTTCTATTTCTATTTTTTCTGCAGCAGTTGGGTTAGAGGAGGAGGAGCCTTTTAGCCTCTCATAAACTGA
CCTCTCTACTTCCTCGTGTATTTTTAAGATTGATTGATGATGTGGAAAGGGCTTTGCTTGTCTGCTACTGAAAACTTTATCCTTGCGGTT
TTTGTGGAAACTGCTTTTGGAAAGAGAAAAGAAATGAACTTTACTGACTTGACATTTTTGCACCTCCCGTTTTTCTAATCTGGGCTATTT
TTATTTTTGTTTTTTTACAGTGAGATTTTTTTGATCTTCAGCTACAGTAAGTTATTCCAATTTTTTTTTAACATTTTTCCTGACTTTCCG
CTGATTTCCTTTTTATTGTTGTTACTAGTTACTATTACTTATTATTATTATATTAATACTTATGATGGTGATGATGATGATGATAATGAC
ACTGATGATTTTTAACCGGATTAAAATCGAGTTTTTCTGAATGTTTCTAAGAATTTCTCCGGCCTCCTGATTGACTTTGGAGTTTTGCAT
CTTGGGAGAGAAAGCGAAGGCATTAGTATTTTTAAGTGGTTTGATCACGTAAACCTTTTCTCTCCCAACCCCACCCTTGCCCTCATCCCC
TTCCCCACACTGAAAAGAATTTTACTGGCTGTTAAGTCTATGACCTTATTTTTCCTGATCTTTAACTTAACTGTTTTAGAGCATCTCTGG
ACGTCTGTATTTTTAATTTTTTTTATTTTTGTTTTTTTATTTTTAATCTTTCATTTGTTAAATTTTTAAACTGTGCTGCAATAAAATGTG
TGTGGTACTACTTAACACTTATGATCGTGATGGCATTTTCCCTGAAAGCCATCTTCCTCCTGTTTCCCTTGAAATCCCATCCTGCTTTTC
CTGTACACTACCCCTCACAAACCACAAGCTGCAGCAACATGGATGCCCAGCCTGGAGCAGCAGCAGCCAGGATGACCTGGAGCCAGGGGG
GCCTTCGGAACAGATGCACACCCTTCCTGGGTGATGTTTTCGGCTTTGTGAGAAACCTTACCATCAAACACGATGGCCAGCAACGTTACC
AACAAGACAGATCCTCGCTCCATGAACTCCCGTGTATTCATTGGGAATCTCAACACTCTTGTGGTCAAGAAATCTGATGTGGAGGCAATC
TTTTCGAAGTATGGCAAAATTGTGGGCTGCTCTGTTCATAAGGGCTTTGCCTTCGTTCAGTATGTTAATGAGAGAAATGCCCGGGCTGCT
GTAGCAGGAGAGGATGGCAGAATGATTGCTGGCCAGGTTTTAGATATTAACCTGGCTGCAGAGCCAAAAGTGAACCGAGGAAAAGCAGGT
GTGAAACGATCTGCAGCGGAGATGTACGGCTCCTCTTTTGACTTGGACTATGACTTTCAACGGGACTATTATGATAGACTTCATCTGCAG
AGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAGCAAGAAATTAATGGACAAAACGAAAAGGGGAGGTCTTTTTA
GTTAAGCTGGCAATTACCAGAACAATTATGTTTCTTGCTGTATTATAAGAGGATAGCTATATTTTATTTCTGAAGAGTAAGGAGTAGTAT
TTTGGCTTAAAAATCATTCTAATTACAAAGTTCACTGTTTATTGAAGAACTGGCATCTTAAATCAGCCTTCCGCAATTCATGTAGTTTCT
GGGTCTTCTGGGAGCCTACGTGAGTACATCACCTAACAGAATATTAAATTAGACTTCCTGTAAGATTGCTTTAAGAAACTGTTACTGTCC
TGTTTTCTAATCTCTTTATTAAAACAGTGTATTTGGAAAATGTTATGTGCTCTGATTTGATATAGATAACAGATTAGTAGTTACATGGTA
ATTATGTGATATAAAATATTCATATATTATCAAAATTCTGTTTTGTAAATGTAAGAAAGCATAGTTATTTTACAAATTGTTTTTACTGTC
TTTTGAAGAAGTTCTTAAATACGTTGTTAAATGGTATTAGTTGACCAGGGCAGTGAAAATGAAACCGCATTTTGGGTGCCATTAAATAGG
GAAAAAACATGTAAAAAATGTAAAATGGAGACCAATTGCACTAGGCAAGTGTATATTTTGTATTTTATATACAATTTCTATTATTTTTCA

>37144_37144_2_HNRNPC-WRN_HNRNPC_chr14_21698478_ENST00000430246_WRN_chr8_31030511_ENST00000298139_length(amino acids)=146AA_BP=
MDVCIFNFFYFCFFIFNLSFVKFLNCAAIKCVWYYLTLMIVMAFSLKAIFLLFPLKSHPAFPVHYPSQTTSCSNMDAQPGAAAARMTWSQ

--------------------------------------------------------------
>37144_37144_3_HNRNPC-WRN_HNRNPC_chr14_21698478_ENST00000556897_WRN_chr8_31030511_ENST00000298139_length(transcript)=1253nt_BP=478nt
GCCTGGAGCAGCAGCAGCCAGGATGACCTGGAGCCAGGGGGGCCTTCGGAACAGATGCACACCCTTCCTGGGTGATGTTTTCGGCTTTGT
GAGAAACCTTACCATCAAACACGATGGCCAGCAACGTTACCAACAAGACAGATCCTCGCTCCATGAACTCCCGTGTATTCATTGGGAATC
TCAACACTCTTGTGGTCAAGAAATCTGATGTGGAGGCAATCTTTTCGAAGTATGGCAAAATTGTGGGCTGCTCTGTTCATAAGGGCTTTG
CCTTCGTTCAGTATGTTAATGAGAGAAATGCCCGGGCTGCTGTAGCAGGAGAGGATGGCAGAATGATTGCTGGCCAGGTTTTAGATATTA
ACCTGGCTGCAGAGCCAAAAGTGAACCGAGGAAAAGCAGGTGTGAAACGATCTGCAGCGGAGATGTACGGCTCCTCTTTTGACTTGGACT
ATGACTTTCAACGGGACTATTATGATAGACTTCATCTGCAGAGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAG
CAAGAAATTAATGGACAAAACGAAAAGGGGAGGTCTTTTTAGTTAAGCTGGCAATTACCAGAACAATTATGTTTCTTGCTGTATTATAAG
AGGATAGCTATATTTTATTTCTGAAGAGTAAGGAGTAGTATTTTGGCTTAAAAATCATTCTAATTACAAAGTTCACTGTTTATTGAAGAA
CTGGCATCTTAAATCAGCCTTCCGCAATTCATGTAGTTTCTGGGTCTTCTGGGAGCCTACGTGAGTACATCACCTAACAGAATATTAAAT
TAGACTTCCTGTAAGATTGCTTTAAGAAACTGTTACTGTCCTGTTTTCTAATCTCTTTATTAAAACAGTGTATTTGGAAAATGTTATGTG
CTCTGATTTGATATAGATAACAGATTAGTAGTTACATGGTAATTATGTGATATAAAATATTCATATATTATCAAAATTCTGTTTTGTAAA
TGTAAGAAAGCATAGTTATTTTACAAATTGTTTTTACTGTCTTTTGAAGAAGTTCTTAAATACGTTGTTAAATGGTATTAGTTGACCAGG
GCAGTGAAAATGAAACCGCATTTTGGGTGCCATTAAATAGGGAAAAAACATGTAAAAAATGTAAAATGGAGACCAATTGCACTAGGCAAG

>37144_37144_3_HNRNPC-WRN_HNRNPC_chr14_21698478_ENST00000556897_WRN_chr8_31030511_ENST00000298139_length(amino acids)=145AA_BP=121
MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAAEPKV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HNRNPC-WRN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneWRNchr14:21698478chr8:31030511ENST000002981393335987_9931397.01433.0DNA
TgeneWRNchr14:21698478chr8:31030511ENST0000029813933352_2771397.01433.0WRNIP1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for HNRNPC-WRN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for HNRNPC-WRN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource