Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HNRNPH1-RPL6 (FusionGDB2 ID:37201)

Fusion Gene Summary for HNRNPH1-RPL6

Fusion gene summary

Fusion gene information	Fusion gene name: HNRNPH1-RPL6
	Fusion gene ID: 37201
		Hgene	Tgene
	Gene symbol	HNRNPH1	RPL6
	Gene ID	3187	6128
	Gene name	heterogeneous nuclear ribonucleoprotein H1	ribosomal protein L6
	Synonyms	HNRPH\|HNRPH1\|hnRNPH	L6\|SHUJUN-2\|TAXREB107\|TXREB1
	Cytomap	5q35.3	12q24.13
	Type of gene	protein-coding	protein-coding
	Description	heterogeneous nuclear ribonucleoprotein Hepididymis secretory sperm binding proteinheterogeneous nuclear ribonucleoprotein H1 (H)	60S ribosomal protein L6DNA-binding protein TAXREB107large ribosomal subunit protein eL6neoplasm-related protein C140tax-responsive enhancer element-binding protein 107
	Modification date	20200320	20200327
	UniProtAcc	P31943	.
	Ensembl transtripts involved in fusion gene	ENST00000524180, ENST00000329433, ENST00000356731, ENST00000393432, ENST00000442819, ENST00000510411, ENST00000511300,	ENST00000202773, ENST00000424576,
Fusion gene scores	* DoF score	21 X 18 X 8=3024	8 X 9 X 4=288
	# samples	21	9
	** MAII score	log2(21/3024*10)=-3.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HNRNPH1 [Title/Abstract] AND RPL6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HNRNPH1(179050038)-RPL6(112844146), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HNRNPH1	GO:0043484	regulation of RNA splicing	16946708
Tgene	RPL6	GO:0002181	cytoplasmic translation	25957688

Fusion gene breakpoints across HNRNPH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RPL6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	ERR188441	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-

Top

Fusion Gene ORF analysis for HNRNPH1-RPL6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000524180	ENST00000202773	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
5UTR-3CDS	ENST00000524180	ENST00000424576	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
In-frame	ENST00000329433	ENST00000202773	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
In-frame	ENST00000329433	ENST00000424576	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
In-frame	ENST00000356731	ENST00000202773	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
In-frame	ENST00000356731	ENST00000424576	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
In-frame	ENST00000393432	ENST00000202773	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
In-frame	ENST00000393432	ENST00000424576	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
In-frame	ENST00000442819	ENST00000202773	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
In-frame	ENST00000442819	ENST00000424576	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
In-frame	ENST00000510411	ENST00000202773	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
In-frame	ENST00000510411	ENST00000424576	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
intron-3CDS	ENST00000511300	ENST00000202773	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
intron-3CDS	ENST00000511300	ENST00000424576	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393432	HNRNPH1	chr5	179050038	-	ENST00000202773	RPL6	chr12	112844146	-	656	244	220	630	136
ENST00000393432	HNRNPH1	chr5	179050038	-	ENST00000424576	RPL6	chr12	112844146	-	652	244	220	630	136
ENST00000442819	HNRNPH1	chr5	179050038	-	ENST00000202773	RPL6	chr12	112844146	-	626	214	190	600	136
ENST00000442819	HNRNPH1	chr5	179050038	-	ENST00000424576	RPL6	chr12	112844146	-	622	214	190	600	136
ENST00000356731	HNRNPH1	chr5	179050038	-	ENST00000202773	RPL6	chr12	112844146	-	2045	1633	934	1539	201
ENST00000356731	HNRNPH1	chr5	179050038	-	ENST00000424576	RPL6	chr12	112844146	-	2041	1633	934	1539	201
ENST00000329433	HNRNPH1	chr5	179050038	-	ENST00000202773	RPL6	chr12	112844146	-	544	132	108	518	136
ENST00000329433	HNRNPH1	chr5	179050038	-	ENST00000424576	RPL6	chr12	112844146	-	540	132	108	518	136
ENST00000510411	HNRNPH1	chr5	179050038	-	ENST00000202773	RPL6	chr12	112844146	-	545	133	109	519	136
ENST00000510411	HNRNPH1	chr5	179050038	-	ENST00000424576	RPL6	chr12	112844146	-	541	133	109	519	136

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393432	ENST00000202773	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-	0.019377615	0.9806224
ENST00000393432	ENST00000424576	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-	0.018047787	0.98195225
ENST00000442819	ENST00000202773	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-	0.017892282	0.9821077
ENST00000442819	ENST00000424576	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-	0.01567368	0.9843263
ENST00000356731	ENST00000202773	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-	0.09276689	0.9072332
ENST00000356731	ENST00000424576	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-	0.09057042	0.9094296
ENST00000329433	ENST00000202773	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-	0.021794252	0.97820574
ENST00000329433	ENST00000424576	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-	0.01967144	0.98032856
ENST00000510411	ENST00000202773	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-	0.019637035	0.98036295
ENST00000510411	ENST00000424576	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-	0.018383486	0.9816165

Top

Fusion Genomic Features for HNRNPH1-RPL6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for HNRNPH1-RPL6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:179050038/chr12:112844146)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HNRNPH1 P31943	.
FUNCTION: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269\|PubMed:11003644, ECO:0000269\|PubMed:16946708}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000356731

111_188

130.66666666666666

Domain

RRM 2

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000356731

11_90

130.66666666666666

Domain

RRM 1

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000356731

289_364

130.66666666666666

Domain

RRM 3

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000393432

111_188

646.0

Domain

RRM 2

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000393432

11_90

646.0

Domain

RRM 1

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000393432

289_364

646.0

Domain

RRM 3

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000442819

111_188

655.6666666666666

Domain

RRM 2

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000442819

11_90

655.6666666666666

Domain

RRM 1

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000442819

289_364

655.6666666666666

Domain

RRM 3

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000356731

234_433

130.66666666666666

Region

Note=2 X 16 AA Gly-rich approximate repeats

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000356731

354_392

130.66666666666666

Region

Note=2 X 19 AA perfect repeats

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000393432

234_433

646.0

Region

Note=2 X 16 AA Gly-rich approximate repeats

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000393432

354_392

646.0

Region

Note=2 X 19 AA perfect repeats

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000442819

234_433

655.6666666666666

Region

Note=2 X 16 AA Gly-rich approximate repeats

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000442819

354_392

655.6666666666666

Region

Note=2 X 19 AA perfect repeats

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000356731

234_249

130.66666666666666

Repeat

Note=1-1

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000356731

354_372

130.66666666666666

Repeat

Note=2-1

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000356731

374_392

130.66666666666666

Repeat

Note=2-2

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000356731

418_433

130.66666666666666

Repeat

Note=1-2

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000393432

234_249

646.0

Repeat

Note=1-1

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000393432

354_372

646.0

Repeat

Note=2-1

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000393432

374_392

646.0

Repeat

Note=2-2

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000393432

418_433

646.0

Repeat

Note=1-2

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000442819

234_249

655.6666666666666

Repeat

Note=1-1

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000442819

354_372

655.6666666666666

Repeat

Note=2-1

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000442819

374_392

655.6666666666666

Repeat

Note=2-2

Hgene

HNRNPH1

chr5:179050038

chr12:112844146

ENST00000442819

418_433

655.6666666666666

Repeat

Note=1-2

Top

Fusion Gene Sequence for HNRNPH1-RPL6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>37201_37201_1_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000329433_RPL6_chr12_112844146_ENST00000202773_length(transcript)=544nt_BP=132nt
GCAGTTTGTTTCGACGCCGGACCGCGTAAGAGACGATGATGTTGGGCACGGAAGGTGGAGAGGGATTCGTGGTGAAGGTCCGGGGCTTGC
CCTGGTCTTGCTCGGCCGATGAAGTGCAGAGGTTTTTTTCTGAGGGTGGTTTTCCTGAAGCAGCTGGCTAGTGGCTTATTACTTGTGACT
GGACCTCTGGTCCTCAATCGAGTTCCTCTACGAAGAACACACCAGAAATTTGTCATTGCCACTTCAACCAAAATCGATATCAGCAATGTA
AAAATCCCAAAACATCTTACTGATGCTTACTTCAAGAAGAAGAAGCTGCGGAAGCCCAGACACCAGGAAGGTGAGATCTTCGACACAGAA
AAAGAGAAATATGAGATTACGGAGCAGCGCAAGATTGATCAGAAAGCTGTGGACTCACAAATTTTACCAAAAATCAAAGCTATTCCTCAG
CTCCAGGGCTACCTGCGATCTGTGTTTGCTCTGACGAATGGAATTTATCCTCACAAATTGGTGTTCTAAATGTCTTAAGAACCTAATTAA

>37201_37201_1_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000329433_RPL6_chr12_112844146_ENST00000202773_length(amino acids)=136AA_BP=8
MKCRGFFLRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEI

--------------------------------------------------------------
>37201_37201_2_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000329433_RPL6_chr12_112844146_ENST00000424576_length(transcript)=540nt_BP=132nt
GCAGTTTGTTTCGACGCCGGACCGCGTAAGAGACGATGATGTTGGGCACGGAAGGTGGAGAGGGATTCGTGGTGAAGGTCCGGGGCTTGC
CCTGGTCTTGCTCGGCCGATGAAGTGCAGAGGTTTTTTTCTGAGGGTGGTTTTCCTGAAGCAGCTGGCTAGTGGCTTATTACTTGTGACT
GGACCTCTGGTCCTCAATCGAGTTCCTCTACGAAGAACACACCAGAAATTTGTCATTGCCACTTCAACCAAAATCGATATCAGCAATGTA
AAAATCCCAAAACATCTTACTGATGCTTACTTCAAGAAGAAGAAGCTGCGGAAGCCCAGACACCAGGAAGGTGAGATCTTCGACACAGAA
AAAGAGAAATATGAGATTACGGAGCAGCGCAAGATTGATCAGAAAGCTGTGGACTCACAAATTTTACCAAAAATCAAAGCTATTCCTCAG
CTCCAGGGCTACCTGCGATCTGTGTTTGCTCTGACGAATGGAATTTATCCTCACAAATTGGTGTTCTAAATGTCTTAAGAACCTAATTAA

>37201_37201_2_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000329433_RPL6_chr12_112844146_ENST00000424576_length(amino acids)=136AA_BP=8
MKCRGFFLRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEI

--------------------------------------------------------------
>37201_37201_3_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000356731_RPL6_chr12_112844146_ENST00000202773_length(transcript)=2045nt_BP=1633nt
GTGCTGCTAGAAACCACGAACATTAGTCATCTCGCAGCATGTGTGCACATGGGGTGACCCGGGGGCCTCCTCGAATGCAGCGTCTACGCC
TGGTGAATGGACGCACTCTTACCAATTCTGCTCTGGGAGATGCAGCGGTAACCTACCGAGCGCAGAGGCCGGCGCGCACCCGTGGAGCCC
GCGCTCGCGATCCCTCCTCGTGCCAGGGCCCCAGGGCAGTCAAGGCCTGCCGACCGTTAGGCGGGTCAAGGGGTACACAGGGTGCGAATT
CGTTAGGCAAAAGCTGGGTACAGGCGCGAGCCACAGGCACGGAAACCTCGCGCCGACCGGGGCCCTAGGCCCGACGACGGCAGGTAAGGG
GAAGTGGAGGCACACAGGGCTGGGACGTGCCCCAGGCACCATACGGGTGGCTTCGGGCGCGGGACGTCCGCAGCCCCGCAGCTCCCAGGA
CGTTCGACAATCTGCAGCTGACCAGCTTCGGCCGGTTTGGGGATAAAGGGAAGACAGGCGGCGCGGGGAGTGGGAACGCCTGAAGGCCGC
GCCCCTCCTTTCAGGTCGGCCAGGAGCGCGCCGGTAAGAGCCTGGGGGCAAGGGGTAGAAAGACGCCCACCTCATCACAACCCAGAGCTC
GGGACTCCTATACAGTCCCATAGGGAACAGGCGGCCGCCATTCCCCTCCCCCACGCTGGCGGGTAAGGCTAGAGAACGGTTTCAAGGAAG
ACGCATGCGCATGAAATAATTATAAACCGCTAGGACTCCGAAGTTCAATATTCGCGGGAAGGCGCAGGCGCAACAAAAAGCCCGGCGGGT
TTATGGGTGGGGGTGCTGAGCCCAAAACCCAAGCGTGTAATAATCCGCCGGCGGGAGGTGGGCTGGCTCTTGAAATTACGCATGCGCCAG
AGCTCTTTGTGACGCAACGGGGCGGTGCGGGCAGCTGGCTGCGCGTGCGCAGAACTCGCACAAGGGACCTTATTTAGGTTGCGCAGGCGC
CCGCTGGCCATTTCGTCTTAGCCACGCAGAAGTCGCGTGTCTAGGTGAGTCGCGGTGGGTCCTCGCTTGCAGTTCAGCGACCACGGTGGG
TACCGTTTTTGCGAGGATTGTTTGTCCCCATATCTCTGGGAGGGCCACGGGGACCTTGGCGAGCTGCAGGCTGCCGTCGAGAGCCGCGAG
TGGTTCGCTGAATCTCGGCACCGCCGCTGAGGCCTGCAGGCCGCGCCGACTCTATTGTGTGAGAAGTCGGAGGAGGCGGAGCGGAAGCGG
CCGCCGCCATTTCCTTTCCTCTACGCTGGCTCTCGGCCCGGGCCCCCACGGTTCGGGGCGCCGACAGCTGTTGCTCAGGACAGCTTTGGG
GGTCCGGTCGCCGGACGAGGAGGTGTTGGAGTCGCCGGGGTGGGTGCATCCGCCCGGTTTTTGCTCCGTGGGGGGGCGGTGCGGGCCCGG
GCGCGCCTCGGAGGCGAAGGACAGCTTAATTGGCGCTCTCAGTTCTGGTCCTCCCCGCTTTGCAGTTTGTTTCGACGCCGGACCGCGTAA
GAGACGATGATGTTGGGCACGGAAGGTGGAGAGGGATTCGTGGTGAAGGTCCGGGGCTTGCCCTGGTCTTGCTCGGCCGATGAAGTGCAG
AGGTTTTTTTCTGAGGGTGGTTTTCCTGAAGCAGCTGGCTAGTGGCTTATTACTTGTGACTGGACCTCTGGTCCTCAATCGAGTTCCTCT
ACGAAGAACACACCAGAAATTTGTCATTGCCACTTCAACCAAAATCGATATCAGCAATGTAAAAATCCCAAAACATCTTACTGATGCTTA
CTTCAAGAAGAAGAAGCTGCGGAAGCCCAGACACCAGGAAGGTGAGATCTTCGACACAGAAAAAGAGAAATATGAGATTACGGAGCAGCG
CAAGATTGATCAGAAAGCTGTGGACTCACAAATTTTACCAAAAATCAAAGCTATTCCTCAGCTCCAGGGCTACCTGCGATCTGTGTTTGC

>37201_37201_3_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000356731_RPL6_chr12_112844146_ENST00000202773_length(amino acids)=201AA_BP=
MAARAQNSHKGPYLGCAGARWPFRLSHAEVACLGESRWVLACSSATTVGTVFARIVCPHISGRATGTLASCRLPSRAASGSLNLGTAAEA
CRPRRLYCVRSRRRRSGSGRRHFLSSTLALGPGPHGSGRRQLLLRTALGVRSPDEEVLESPGWVHPPGFCSVGGRCGPGRASEAKDSLIG

--------------------------------------------------------------
>37201_37201_4_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000356731_RPL6_chr12_112844146_ENST00000424576_length(transcript)=2041nt_BP=1633nt
GTGCTGCTAGAAACCACGAACATTAGTCATCTCGCAGCATGTGTGCACATGGGGTGACCCGGGGGCCTCCTCGAATGCAGCGTCTACGCC
TGGTGAATGGACGCACTCTTACCAATTCTGCTCTGGGAGATGCAGCGGTAACCTACCGAGCGCAGAGGCCGGCGCGCACCCGTGGAGCCC
GCGCTCGCGATCCCTCCTCGTGCCAGGGCCCCAGGGCAGTCAAGGCCTGCCGACCGTTAGGCGGGTCAAGGGGTACACAGGGTGCGAATT
CGTTAGGCAAAAGCTGGGTACAGGCGCGAGCCACAGGCACGGAAACCTCGCGCCGACCGGGGCCCTAGGCCCGACGACGGCAGGTAAGGG
GAAGTGGAGGCACACAGGGCTGGGACGTGCCCCAGGCACCATACGGGTGGCTTCGGGCGCGGGACGTCCGCAGCCCCGCAGCTCCCAGGA
CGTTCGACAATCTGCAGCTGACCAGCTTCGGCCGGTTTGGGGATAAAGGGAAGACAGGCGGCGCGGGGAGTGGGAACGCCTGAAGGCCGC
GCCCCTCCTTTCAGGTCGGCCAGGAGCGCGCCGGTAAGAGCCTGGGGGCAAGGGGTAGAAAGACGCCCACCTCATCACAACCCAGAGCTC
GGGACTCCTATACAGTCCCATAGGGAACAGGCGGCCGCCATTCCCCTCCCCCACGCTGGCGGGTAAGGCTAGAGAACGGTTTCAAGGAAG
ACGCATGCGCATGAAATAATTATAAACCGCTAGGACTCCGAAGTTCAATATTCGCGGGAAGGCGCAGGCGCAACAAAAAGCCCGGCGGGT
TTATGGGTGGGGGTGCTGAGCCCAAAACCCAAGCGTGTAATAATCCGCCGGCGGGAGGTGGGCTGGCTCTTGAAATTACGCATGCGCCAG
AGCTCTTTGTGACGCAACGGGGCGGTGCGGGCAGCTGGCTGCGCGTGCGCAGAACTCGCACAAGGGACCTTATTTAGGTTGCGCAGGCGC
CCGCTGGCCATTTCGTCTTAGCCACGCAGAAGTCGCGTGTCTAGGTGAGTCGCGGTGGGTCCTCGCTTGCAGTTCAGCGACCACGGTGGG
TACCGTTTTTGCGAGGATTGTTTGTCCCCATATCTCTGGGAGGGCCACGGGGACCTTGGCGAGCTGCAGGCTGCCGTCGAGAGCCGCGAG
TGGTTCGCTGAATCTCGGCACCGCCGCTGAGGCCTGCAGGCCGCGCCGACTCTATTGTGTGAGAAGTCGGAGGAGGCGGAGCGGAAGCGG
CCGCCGCCATTTCCTTTCCTCTACGCTGGCTCTCGGCCCGGGCCCCCACGGTTCGGGGCGCCGACAGCTGTTGCTCAGGACAGCTTTGGG
GGTCCGGTCGCCGGACGAGGAGGTGTTGGAGTCGCCGGGGTGGGTGCATCCGCCCGGTTTTTGCTCCGTGGGGGGGCGGTGCGGGCCCGG
GCGCGCCTCGGAGGCGAAGGACAGCTTAATTGGCGCTCTCAGTTCTGGTCCTCCCCGCTTTGCAGTTTGTTTCGACGCCGGACCGCGTAA
GAGACGATGATGTTGGGCACGGAAGGTGGAGAGGGATTCGTGGTGAAGGTCCGGGGCTTGCCCTGGTCTTGCTCGGCCGATGAAGTGCAG
AGGTTTTTTTCTGAGGGTGGTTTTCCTGAAGCAGCTGGCTAGTGGCTTATTACTTGTGACTGGACCTCTGGTCCTCAATCGAGTTCCTCT
ACGAAGAACACACCAGAAATTTGTCATTGCCACTTCAACCAAAATCGATATCAGCAATGTAAAAATCCCAAAACATCTTACTGATGCTTA
CTTCAAGAAGAAGAAGCTGCGGAAGCCCAGACACCAGGAAGGTGAGATCTTCGACACAGAAAAAGAGAAATATGAGATTACGGAGCAGCG
CAAGATTGATCAGAAAGCTGTGGACTCACAAATTTTACCAAAAATCAAAGCTATTCCTCAGCTCCAGGGCTACCTGCGATCTGTGTTTGC

>37201_37201_4_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000356731_RPL6_chr12_112844146_ENST00000424576_length(amino acids)=201AA_BP=
MAARAQNSHKGPYLGCAGARWPFRLSHAEVACLGESRWVLACSSATTVGTVFARIVCPHISGRATGTLASCRLPSRAASGSLNLGTAAEA
CRPRRLYCVRSRRRRSGSGRRHFLSSTLALGPGPHGSGRRQLLLRTALGVRSPDEEVLESPGWVHPPGFCSVGGRCGPGRASEAKDSLIG

--------------------------------------------------------------
>37201_37201_5_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000393432_RPL6_chr12_112844146_ENST00000202773_length(transcript)=656nt_BP=244nt
ACAAGGGACCTTATTTAGGTTGCGCAGGCGCCCGCTGGCCATTTCGTCTTAGCCACGCAGAAGTCGCGTGTCTAGGTGAGTCGCGGTGGG
TCCTCGCTTGCAGTTCAGCGACCACGTTTGTTTCGACGCCGGACCGCGTAAGAGACGATGATGTTGGGCACGGAAGGTGGAGAGGGATTC
GTGGTGAAGGTCCGGGGCTTGCCCTGGTCTTGCTCGGCCGATGAAGTGCAGAGGTTTTTTTCTGAGGGTGGTTTTCCTGAAGCAGCTGGC
TAGTGGCTTATTACTTGTGACTGGACCTCTGGTCCTCAATCGAGTTCCTCTACGAAGAACACACCAGAAATTTGTCATTGCCACTTCAAC
CAAAATCGATATCAGCAATGTAAAAATCCCAAAACATCTTACTGATGCTTACTTCAAGAAGAAGAAGCTGCGGAAGCCCAGACACCAGGA
AGGTGAGATCTTCGACACAGAAAAAGAGAAATATGAGATTACGGAGCAGCGCAAGATTGATCAGAAAGCTGTGGACTCACAAATTTTACC
AAAAATCAAAGCTATTCCTCAGCTCCAGGGCTACCTGCGATCTGTGTTTGCTCTGACGAATGGAATTTATCCTCACAAATTGGTGTTCTA

>37201_37201_5_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000393432_RPL6_chr12_112844146_ENST00000202773_length(amino acids)=136AA_BP=8
MKCRGFFLRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEI

--------------------------------------------------------------
>37201_37201_6_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000393432_RPL6_chr12_112844146_ENST00000424576_length(transcript)=652nt_BP=244nt
ACAAGGGACCTTATTTAGGTTGCGCAGGCGCCCGCTGGCCATTTCGTCTTAGCCACGCAGAAGTCGCGTGTCTAGGTGAGTCGCGGTGGG
TCCTCGCTTGCAGTTCAGCGACCACGTTTGTTTCGACGCCGGACCGCGTAAGAGACGATGATGTTGGGCACGGAAGGTGGAGAGGGATTC
GTGGTGAAGGTCCGGGGCTTGCCCTGGTCTTGCTCGGCCGATGAAGTGCAGAGGTTTTTTTCTGAGGGTGGTTTTCCTGAAGCAGCTGGC
TAGTGGCTTATTACTTGTGACTGGACCTCTGGTCCTCAATCGAGTTCCTCTACGAAGAACACACCAGAAATTTGTCATTGCCACTTCAAC
CAAAATCGATATCAGCAATGTAAAAATCCCAAAACATCTTACTGATGCTTACTTCAAGAAGAAGAAGCTGCGGAAGCCCAGACACCAGGA
AGGTGAGATCTTCGACACAGAAAAAGAGAAATATGAGATTACGGAGCAGCGCAAGATTGATCAGAAAGCTGTGGACTCACAAATTTTACC
AAAAATCAAAGCTATTCCTCAGCTCCAGGGCTACCTGCGATCTGTGTTTGCTCTGACGAATGGAATTTATCCTCACAAATTGGTGTTCTA

>37201_37201_6_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000393432_RPL6_chr12_112844146_ENST00000424576_length(amino acids)=136AA_BP=8
MKCRGFFLRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEI

--------------------------------------------------------------
>37201_37201_7_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000442819_RPL6_chr12_112844146_ENST00000202773_length(transcript)=626nt_BP=214nt
GCAGAACTCGCACAAGGGACCTTATTTAGGTTGCGCAGGCGCCCGCTGGCCATTTCGTCTTAGCCACGCAGAAGTCGCGTGTCTAGTTTG
TTTCGACGCCGGACCGCGTAAGAGACGATGATGTTGGGCACGGAAGGTGGAGAGGGATTCGTGGTGAAGGTCCGGGGCTTGCCCTGGTCT
TGCTCGGCCGATGAAGTGCAGAGGTTTTTTTCTGAGGGTGGTTTTCCTGAAGCAGCTGGCTAGTGGCTTATTACTTGTGACTGGACCTCT
GGTCCTCAATCGAGTTCCTCTACGAAGAACACACCAGAAATTTGTCATTGCCACTTCAACCAAAATCGATATCAGCAATGTAAAAATCCC
AAAACATCTTACTGATGCTTACTTCAAGAAGAAGAAGCTGCGGAAGCCCAGACACCAGGAAGGTGAGATCTTCGACACAGAAAAAGAGAA
ATATGAGATTACGGAGCAGCGCAAGATTGATCAGAAAGCTGTGGACTCACAAATTTTACCAAAAATCAAAGCTATTCCTCAGCTCCAGGG

>37201_37201_7_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000442819_RPL6_chr12_112844146_ENST00000202773_length(amino acids)=136AA_BP=8
MKCRGFFLRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEI

--------------------------------------------------------------
>37201_37201_8_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000442819_RPL6_chr12_112844146_ENST00000424576_length(transcript)=622nt_BP=214nt
GCAGAACTCGCACAAGGGACCTTATTTAGGTTGCGCAGGCGCCCGCTGGCCATTTCGTCTTAGCCACGCAGAAGTCGCGTGTCTAGTTTG
TTTCGACGCCGGACCGCGTAAGAGACGATGATGTTGGGCACGGAAGGTGGAGAGGGATTCGTGGTGAAGGTCCGGGGCTTGCCCTGGTCT
TGCTCGGCCGATGAAGTGCAGAGGTTTTTTTCTGAGGGTGGTTTTCCTGAAGCAGCTGGCTAGTGGCTTATTACTTGTGACTGGACCTCT
GGTCCTCAATCGAGTTCCTCTACGAAGAACACACCAGAAATTTGTCATTGCCACTTCAACCAAAATCGATATCAGCAATGTAAAAATCCC
AAAACATCTTACTGATGCTTACTTCAAGAAGAAGAAGCTGCGGAAGCCCAGACACCAGGAAGGTGAGATCTTCGACACAGAAAAAGAGAA
ATATGAGATTACGGAGCAGCGCAAGATTGATCAGAAAGCTGTGGACTCACAAATTTTACCAAAAATCAAAGCTATTCCTCAGCTCCAGGG

>37201_37201_8_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000442819_RPL6_chr12_112844146_ENST00000424576_length(amino acids)=136AA_BP=8
MKCRGFFLRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEI

--------------------------------------------------------------
>37201_37201_9_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000510411_RPL6_chr12_112844146_ENST00000202773_length(transcript)=545nt_BP=133nt
TGCAGTTTGTTTCGACGCCGGACCGCGTAAGAGACGATGATGTTGGGCACGGAAGGTGGAGAGGGATTCGTGGTGAAGGTCCGGGGCTTG
CCCTGGTCTTGCTCGGCCGATGAAGTGCAGAGGTTTTTTTCTGAGGGTGGTTTTCCTGAAGCAGCTGGCTAGTGGCTTATTACTTGTGAC
TGGACCTCTGGTCCTCAATCGAGTTCCTCTACGAAGAACACACCAGAAATTTGTCATTGCCACTTCAACCAAAATCGATATCAGCAATGT
AAAAATCCCAAAACATCTTACTGATGCTTACTTCAAGAAGAAGAAGCTGCGGAAGCCCAGACACCAGGAAGGTGAGATCTTCGACACAGA
AAAAGAGAAATATGAGATTACGGAGCAGCGCAAGATTGATCAGAAAGCTGTGGACTCACAAATTTTACCAAAAATCAAAGCTATTCCTCA
GCTCCAGGGCTACCTGCGATCTGTGTTTGCTCTGACGAATGGAATTTATCCTCACAAATTGGTGTTCTAAATGTCTTAAGAACCTAATTA

>37201_37201_9_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000510411_RPL6_chr12_112844146_ENST00000202773_length(amino acids)=136AA_BP=8
MKCRGFFLRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEI

--------------------------------------------------------------
>37201_37201_10_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000510411_RPL6_chr12_112844146_ENST00000424576_length(transcript)=541nt_BP=133nt
TGCAGTTTGTTTCGACGCCGGACCGCGTAAGAGACGATGATGTTGGGCACGGAAGGTGGAGAGGGATTCGTGGTGAAGGTCCGGGGCTTG
CCCTGGTCTTGCTCGGCCGATGAAGTGCAGAGGTTTTTTTCTGAGGGTGGTTTTCCTGAAGCAGCTGGCTAGTGGCTTATTACTTGTGAC
TGGACCTCTGGTCCTCAATCGAGTTCCTCTACGAAGAACACACCAGAAATTTGTCATTGCCACTTCAACCAAAATCGATATCAGCAATGT
AAAAATCCCAAAACATCTTACTGATGCTTACTTCAAGAAGAAGAAGCTGCGGAAGCCCAGACACCAGGAAGGTGAGATCTTCGACACAGA
AAAAGAGAAATATGAGATTACGGAGCAGCGCAAGATTGATCAGAAAGCTGTGGACTCACAAATTTTACCAAAAATCAAAGCTATTCCTCA
GCTCCAGGGCTACCTGCGATCTGTGTTTGCTCTGACGAATGGAATTTATCCTCACAAATTGGTGTTCTAAATGTCTTAAGAACCTAATTA

>37201_37201_10_HNRNPH1-RPL6_HNRNPH1_chr5_179050038_ENST00000510411_RPL6_chr12_112844146_ENST00000424576_length(amino acids)=136AA_BP=8
MKCRGFFLRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HNRNPH1-RPL6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for HNRNPH1-RPL6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for HNRNPH1-RPL6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source