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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ALAS1-SRPK2 (FusionGDB2 ID:3723)

Fusion Gene Summary for ALAS1-SRPK2

Fusion gene summary

Fusion gene information	Fusion gene name: ALAS1-SRPK2
	Fusion gene ID: 3723
		Hgene	Tgene
	Gene symbol	ALAS1	SRPK2
	Gene ID	211	6733
	Gene name	5'-aminolevulinate synthase 1	SRSF protein kinase 2
	Synonyms	ALAS\|ALAS-H\|ALAS3\|ALASH\|MIG4	SFRSK2
	Cytomap	3p21.2	7q22.3
	Type of gene	protein-coding	protein-coding
	Description	5-aminolevulinate synthase, nonspecific, mitochondrial5-aminolevulinic acid synthase 1aminolevulinate, delta-, synthase 1delta-ALA synthase 1delta-aminolevulinate synthase 1migration-inducing protein 4	SRSF protein kinase 2SFRS protein kinase 2SR protein kinase 2SR-protein-specific kinase 2serine kinase SRPK2serine/arginine-rich protein-specific kinase 2serine/arginine-rich splicing factor kinase 2serine/threonine-protein kinase SRPK2
	Modification date	20200313	20200313
	UniProtAcc	P13196	.
	Ensembl transtripts involved in fusion gene	ENST00000310271, ENST00000394965, ENST00000469224, ENST00000484952,	ENST00000493638, ENST00000393651, ENST00000489828, ENST00000357311,
Fusion gene scores	* DoF score	6 X 6 X 5=180	13 X 13 X 5=845
	# samples	6	13
	** MAII score	log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/845*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ALAS1 [Title/Abstract] AND SRPK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ALAS1(52238028)-SRPK2(104758469), # samples:1
Anticipated loss of major functional domain due to fusion event.	ALAS1-SRPK2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ALAS1-SRPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ALAS1-SRPK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. ALAS1-SRPK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ALAS1-SRPK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SRPK2	GO:0000245	spliceosomal complex assembly	9472028
Tgene	SRPK2	GO:0006468	protein phosphorylation	9472028
Tgene	SRPK2	GO:0008284	positive regulation of cell proliferation	18559500
Tgene	SRPK2	GO:0008380	RNA splicing	9472028
Tgene	SRPK2	GO:0035556	intracellular signal transduction	9472028
Tgene	SRPK2	GO:0045070	positive regulation of viral genome replication	20498328
Tgene	SRPK2	GO:0045071	negative regulation of viral genome replication	12417631

Fusion gene breakpoints across ALAS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SRPK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8078-01A	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-

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Fusion Gene ORF analysis for ALAS1-SRPK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000310271	ENST00000493638	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
5CDS-intron	ENST00000394965	ENST00000493638	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
5CDS-intron	ENST00000469224	ENST00000493638	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
5CDS-intron	ENST00000484952	ENST00000493638	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
Frame-shift	ENST00000310271	ENST00000393651	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
Frame-shift	ENST00000310271	ENST00000489828	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
Frame-shift	ENST00000394965	ENST00000393651	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
Frame-shift	ENST00000394965	ENST00000489828	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
Frame-shift	ENST00000469224	ENST00000393651	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
Frame-shift	ENST00000469224	ENST00000489828	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
Frame-shift	ENST00000484952	ENST00000393651	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
Frame-shift	ENST00000484952	ENST00000489828	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
In-frame	ENST00000310271	ENST00000357311	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
In-frame	ENST00000394965	ENST00000357311	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
In-frame	ENST00000469224	ENST00000357311	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-
In-frame	ENST00000484952	ENST00000357311	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000469224	ALAS1	chr3	52238028	+	ENST00000357311	SRPK2	chr7	104758469	-	2425	779	196	780	194
ENST00000394965	ALAS1	chr3	52238028	+	ENST00000357311	SRPK2	chr7	104758469	-	2583	937	63	938	291
ENST00000310271	ALAS1	chr3	52238028	+	ENST00000357311	SRPK2	chr7	104758469	-	2368	722	25	723	232
ENST00000484952	ALAS1	chr3	52238028	+	ENST00000357311	SRPK2	chr7	104758469	-	2544	898	315	899	194

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000469224	ENST00000357311	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-	0.001837499	0.99816257
ENST00000394965	ENST00000357311	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-	0.002298012	0.99770194
ENST00000310271	ENST00000357311	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-	0.001218825	0.99878114
ENST00000484952	ENST00000357311	ALAS1	chr3	52238028	+	SRPK2	chr7	104758469	-	0.001585467	0.9984145

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Fusion Genomic Features for ALAS1-SRPK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ALAS1-SRPK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52238028/chr7:104758469)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ALAS1 P13196	.
	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SRPK2

chr3:52238028

chr7:104758469

ENST00000357311

81_684

627

689.0

Domain

Protein kinase

Tgene

SRPK2

chr3:52238028

chr7:104758469

ENST00000393651

81_684

638

700.0

Domain

Protein kinase

Tgene

SRPK2

chr3:52238028

chr7:104758469

ENST00000489828

81_684

627

689.0

Domain

Protein kinase

Tgene

SRPK2

chr3:52238028

chr7:104758469

ENST00000357311

87_95

627

689.0

Nucleotide binding

ATP

Tgene

SRPK2

chr3:52238028

chr7:104758469

ENST00000393651

87_95

638

700.0

Nucleotide binding

ATP

Tgene

SRPK2

chr3:52238028

chr7:104758469

ENST00000489828

87_95

627

689.0

Nucleotide binding

ATP

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Fusion Gene Sequence for ALAS1-SRPK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>3723_3723_1_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000310271_SRPK2_chr7_104758469_ENST00000357311_length(transcript)=2368nt_BP=722nt
ATATTAAGGCGCCGGCGATCGCGGCCTGAGGCTGCTCCCGGACAAGGGCAACGAGCGTTTCGTTTGGACTTCTCGACTTGAGTGCCCGCC
TCCTTCGCCGCCGCCTCTGCAGTCCTCAGCGCAGGAGCCAGCATACTTCCTGAACATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATC
CCGAGTCCCCCAGGCCTTTCTGCAGAAAGCAGGCAAATCTCTGTTGTTCTATGCCCAAAACTGCCCCAAGATGATGGAAGTTGGGGCCAA
GCCAGCCCCTCGGGCATTGTCCACTGCAGCAGTACACTACCAACAGATCAAAGAAACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAA
GGCCAAGGTCCAACAGACTCCTGATGGATCCCAGCAGAGTCCAGATGGCACACAGCTTCCGTCTGGACACCCCTTGCCTGCCACAAGCCA
GGGCACTGCAAGCAAATGCCCTTTCCTGGCAGCACAGATGAATCAGAGAGGCAGCAGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGA
GGATGTGCAGGAAATGAATGCCGTGAGGAAAGAGGTTGCTGAAACCTCAGCAGGCCCCAGTGTGGTTAGTGTGAAAACCGATGGAGGGGA
TCCCAGTGGACTGCTGAAGAACTTCCAGGACATCATGCAAAAGCAAAGACCAGAAAGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAA
ATGAGAACTGCGACACATCACCAAGCTGAAGCCCTGGAGCCTCTTTGATGTACTTGTGGAAAAGTATGGCTGGCCCCATGAAGATGCTGC
ACAGTTTACAGATTTCCTGATCCCGATGTTAGAAATGGTTCCAGAAAAACGAGCCTCAGCTGGCGAATGCCTTCGGCATCCTTGGTTGAA
TTCTTAGCAAATTCTACCAATATTGCATTCTGAGCTAGCAAATGTTCCCAGTACATTGGACCTAAACGGTGACTCTCATTCTTTAACAGG
ATTACAAGTGAGCTGGCTTCATCCTCAGACCTTTATTTTGCTTTGAGGTACTGTTGTTTGACATTTTGCTTTTTGTGCACTGTGATCCTG
GGGAAGGGTAGTCTTTTGTCTTCAGCTAAGTAGTTTACTGACCATTTTCTTCTGGAAACAATAACATGTCTCTAAGCATTGTTTCTTGTG
TTGTGTGACATTCAAATGTCATTTTTTTGAATGAAAAATACTTTCCCCTTTGTGTTTTGGCAGGTTTTGTAACTATTTATGAAGAAATAT
TTTAGCTGAGTACTATATAATTTACAATCTTAAGAAATTATCAAGTTGGAACCAAGAAATAGCAAGGAAATGTACAATTTTATCTTCTGG
CAAAGGGACATCATTCCTGTATTATAGTGTATGTAAATGCACCCTGTAAATGTTACTTTCCATTAAATATGGGAGGGGGACTCAAATTTC
AGAAAAGCTACCAAGTCTTGAGTGCTTTGTAGCCTATGTTGCATGTAGCGGACTTTAACTGCTCCAAGGAGTTGTGCAAACTTTTCATTC
CATAACAGTCTTTTCACATTGGATTTTAAACAAAGTGGCTCTGGGTTATAAGATGTCATTCTCTATATGGCACTTTAAAGGAAGAAAAGA
TATGTTTCTCATTCTAAAATATGCATTATAATTTAGCAGTCCCATTTGTGATTTTGCATATTTTTAAAAGTACTTTTAAAGAAGAGCAAT
TTCCCTTTAAAAATGTGATGGCTCAGTACCATGTCATGTTGCCTCCTCTGGGCGCTGTAAGTTAAGCTCTACATAGATTAAATTGGAGAA
ACGTGTTAATTGTGTGGAATGAAAAAATACATATATTTTTGGAAAAGCATGATCATGCTTGTCTAGAACACAAGGTATGGTATATACAAT
TTGCAGTGCAGTGGGCAGAATACTTCTCACAGCTCAAAGATAACAGTGATCACATTCATTCCATAGGTAGCTTTACGTGTGGCTACAACA
AATTTTACTAGCTTTTTCATTGTCTTTCCATGAAACGAAGTTGAGAAAATGATTTTCCCTTTGCAGGTTGCACACAGTTTTGTTTATGCA
TTTCCTTAAAATTAATTGTAGACTCCAGGATACAAACCATAGTAGGCAATACAATTTTAGAATGTAATATATAGAGGTATATTTAGCCTC
TTTTAGAAGTCAGTGGATTGAATGTCTTTTTATTTTAAATTTTACATTCATTAAGGTGCCTCGTTTTTGACTTTGTCCATTAACATTTAT
CCATATGCCTTTGCAATAACTAGATTGTGAAAAGCTAACAAGTGTTGTAACAATAATCCATTGTTTGAGGTGCTTGCAGTTGTCTTAAAA

>3723_3723_1_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000310271_SRPK2_chr7_104758469_ENST00000357311_length(amino acids)=232AA_BP=
MRLLPDKGNERFVWTSRLECPPPSPPPLQSSAQEPAYFLNMESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALST
AAVHYQQIKETPPASEKDKTAKAKVQQTPDGSQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAV

--------------------------------------------------------------
>3723_3723_2_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000394965_SRPK2_chr7_104758469_ENST00000357311_length(transcript)=2583nt_BP=937nt
AGCGCCCAAGGCGCATGCGCAGCGGTCACTCCCGCTGTATATTAAGGCGCCGGCGATCGCGGCCTGAGGCTGCTCCCGGACAAGGGCAAC
GAGCGTTTCGTTTGGACTTCTCGACTTGAGTGCCCGCCTCCTTCGCCGCCGCCTCTGCAGTCCTCAGCGCAGTTATGCCCAGTTCTTCCC
GCTGTGGGGACACGACCACGGAGGAATCCTTGCTTCAGGGACTCGGGACCCTGCTGGACCCCTTCCTCGGGTTTAGGGGATGTGGGGACC
AGGAGAAAGTCAGGATCCCTAAGAGTCTTCCCTGCCTGGATGGATGAGTGGCTTCTTCTCCACCTAGATGAGCCAGCATACTTCCTGAAC
ATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATCCCGAGTCCCCCAGGCCTTTCTGCAGAAAGCAGGCAAATCTCTGTTGTTCTATGCC
CAAAACTGCCCCAAGATGATGGAAGTTGGGGCCAAGCCAGCCCCTCGGGCATTGTCCACTGCAGCAGTACACTACCAACAGATCAAAGAA
ACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAAGGCCAAGGTCCAACAGACTCCTGATGGATCCCAGCAGAGTCCAGATGGCACACAG
CTTCCGTCTGGACACCCCTTGCCTGCCACAAGCCAGGGCACTGCAAGCAAATGCCCTTTCCTGGCAGCACAGATGAATCAGAGAGGCAGC
AGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGAGGATGTGCAGGAAATGAATGCCGTGAGGAAAGAGGTTGCTGAAACCTCAGCAGGC
CCCAGTGTGGTTAGTGTGAAAACCGATGGAGGGGATCCCAGTGGACTGCTGAAGAACTTCCAGGACATCATGCAAAAGCAAAGACCAGAA
AGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAAATGAGAACTGCGACACATCACCAAGCTGAAGCCCTGGAGCCTCTTTGATGTACTT
GTGGAAAAGTATGGCTGGCCCCATGAAGATGCTGCACAGTTTACAGATTTCCTGATCCCGATGTTAGAAATGGTTCCAGAAAAACGAGCC
TCAGCTGGCGAATGCCTTCGGCATCCTTGGTTGAATTCTTAGCAAATTCTACCAATATTGCATTCTGAGCTAGCAAATGTTCCCAGTACA
TTGGACCTAAACGGTGACTCTCATTCTTTAACAGGATTACAAGTGAGCTGGCTTCATCCTCAGACCTTTATTTTGCTTTGAGGTACTGTT
GTTTGACATTTTGCTTTTTGTGCACTGTGATCCTGGGGAAGGGTAGTCTTTTGTCTTCAGCTAAGTAGTTTACTGACCATTTTCTTCTGG
AAACAATAACATGTCTCTAAGCATTGTTTCTTGTGTTGTGTGACATTCAAATGTCATTTTTTTGAATGAAAAATACTTTCCCCTTTGTGT
TTTGGCAGGTTTTGTAACTATTTATGAAGAAATATTTTAGCTGAGTACTATATAATTTACAATCTTAAGAAATTATCAAGTTGGAACCAA
GAAATAGCAAGGAAATGTACAATTTTATCTTCTGGCAAAGGGACATCATTCCTGTATTATAGTGTATGTAAATGCACCCTGTAAATGTTA
CTTTCCATTAAATATGGGAGGGGGACTCAAATTTCAGAAAAGCTACCAAGTCTTGAGTGCTTTGTAGCCTATGTTGCATGTAGCGGACTT
TAACTGCTCCAAGGAGTTGTGCAAACTTTTCATTCCATAACAGTCTTTTCACATTGGATTTTAAACAAAGTGGCTCTGGGTTATAAGATG
TCATTCTCTATATGGCACTTTAAAGGAAGAAAAGATATGTTTCTCATTCTAAAATATGCATTATAATTTAGCAGTCCCATTTGTGATTTT
GCATATTTTTAAAAGTACTTTTAAAGAAGAGCAATTTCCCTTTAAAAATGTGATGGCTCAGTACCATGTCATGTTGCCTCCTCTGGGCGC
TGTAAGTTAAGCTCTACATAGATTAAATTGGAGAAACGTGTTAATTGTGTGGAATGAAAAAATACATATATTTTTGGAAAAGCATGATCA
TGCTTGTCTAGAACACAAGGTATGGTATATACAATTTGCAGTGCAGTGGGCAGAATACTTCTCACAGCTCAAAGATAACAGTGATCACAT
TCATTCCATAGGTAGCTTTACGTGTGGCTACAACAAATTTTACTAGCTTTTTCATTGTCTTTCCATGAAACGAAGTTGAGAAAATGATTT
TCCCTTTGCAGGTTGCACACAGTTTTGTTTATGCATTTCCTTAAAATTAATTGTAGACTCCAGGATACAAACCATAGTAGGCAATACAAT
TTTAGAATGTAATATATAGAGGTATATTTAGCCTCTTTTAGAAGTCAGTGGATTGAATGTCTTTTTATTTTAAATTTTACATTCATTAAG
GTGCCTCGTTTTTGACTTTGTCCATTAACATTTATCCATATGCCTTTGCAATAACTAGATTGTGAAAAGCTAACAAGTGTTGTAACAATA

>3723_3723_2_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000394965_SRPK2_chr7_104758469_ENST00000357311_length(amino acids)=291AA_BP=
MRLLPDKGNERFVWTSRLECPPPSPPPLQSSAQLCPVLPAVGTRPRRNPCFRDSGPCWTPSSGLGDVGTRRKSGSLRVFPAWMDEWLLLH
LDEPAYFLNMESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKTAKAKVQQTPDG
SQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQ

--------------------------------------------------------------
>3723_3723_3_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000469224_SRPK2_chr7_104758469_ENST00000357311_length(transcript)=2425nt_BP=779nt
AAGAAGGCAGCGCCCAAGGCGCATGCGCAGCGGTCACTCCCGCTGTATATTAAGGCGCCGGCGATCGCGGCCTGAGGCTGCTCCCGGACA
AGGGCAACGAGCGTTTCGTTTGGACTTCTCGACTTGAGTGCCCGCCTCCTTCGCCGCCGCCTCTGCAGTCCTCAGCGCAGTCTTTCCACA
GGAGCCAGCATACTTCCTGAACATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATCCCGAGTCCCCCAGGCCTTTCTGCAGAAAGCAGG
CAAATCTCTGTTGTTCTATGCCCAAAACTGCCCCAAGATGATGGAAGTTGGGGCCAAGCCAGCCCCTCGGGCATTGTCCACTGCAGCAGT
ACACTACCAACAGATCAAAGAAACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAAGGCCAAGGTCCAACAGACTCCTGATGGATCCCA
GCAGAGTCCAGATGGCACACAGCTTCCGTCTGGACACCCCTTGCCTGCCACAAGCCAGGGCACTGCAAGCAAATGCCCTTTCCTGGCAGC
ACAGATGAATCAGAGAGGCAGCAGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGAGGATGTGCAGGAAATGAATGCCGTGAGGAAAGA
GGTTGCTGAAACCTCAGCAGGCCCCAGTGTGGTTAGTGTGAAAACCGATGGAGGGGATCCCAGTGGACTGCTGAAGAACTTCCAGGACAT
CATGCAAAAGCAAAGACCAGAAAGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAAATGAGAACTGCGACACATCACCAAGCTGAAGCC
CTGGAGCCTCTTTGATGTACTTGTGGAAAAGTATGGCTGGCCCCATGAAGATGCTGCACAGTTTACAGATTTCCTGATCCCGATGTTAGA
AATGGTTCCAGAAAAACGAGCCTCAGCTGGCGAATGCCTTCGGCATCCTTGGTTGAATTCTTAGCAAATTCTACCAATATTGCATTCTGA
GCTAGCAAATGTTCCCAGTACATTGGACCTAAACGGTGACTCTCATTCTTTAACAGGATTACAAGTGAGCTGGCTTCATCCTCAGACCTT
TATTTTGCTTTGAGGTACTGTTGTTTGACATTTTGCTTTTTGTGCACTGTGATCCTGGGGAAGGGTAGTCTTTTGTCTTCAGCTAAGTAG
TTTACTGACCATTTTCTTCTGGAAACAATAACATGTCTCTAAGCATTGTTTCTTGTGTTGTGTGACATTCAAATGTCATTTTTTTGAATG
AAAAATACTTTCCCCTTTGTGTTTTGGCAGGTTTTGTAACTATTTATGAAGAAATATTTTAGCTGAGTACTATATAATTTACAATCTTAA
GAAATTATCAAGTTGGAACCAAGAAATAGCAAGGAAATGTACAATTTTATCTTCTGGCAAAGGGACATCATTCCTGTATTATAGTGTATG
TAAATGCACCCTGTAAATGTTACTTTCCATTAAATATGGGAGGGGGACTCAAATTTCAGAAAAGCTACCAAGTCTTGAGTGCTTTGTAGC
CTATGTTGCATGTAGCGGACTTTAACTGCTCCAAGGAGTTGTGCAAACTTTTCATTCCATAACAGTCTTTTCACATTGGATTTTAAACAA
AGTGGCTCTGGGTTATAAGATGTCATTCTCTATATGGCACTTTAAAGGAAGAAAAGATATGTTTCTCATTCTAAAATATGCATTATAATT
TAGCAGTCCCATTTGTGATTTTGCATATTTTTAAAAGTACTTTTAAAGAAGAGCAATTTCCCTTTAAAAATGTGATGGCTCAGTACCATG
TCATGTTGCCTCCTCTGGGCGCTGTAAGTTAAGCTCTACATAGATTAAATTGGAGAAACGTGTTAATTGTGTGGAATGAAAAAATACATA
TATTTTTGGAAAAGCATGATCATGCTTGTCTAGAACACAAGGTATGGTATATACAATTTGCAGTGCAGTGGGCAGAATACTTCTCACAGC
TCAAAGATAACAGTGATCACATTCATTCCATAGGTAGCTTTACGTGTGGCTACAACAAATTTTACTAGCTTTTTCATTGTCTTTCCATGA
AACGAAGTTGAGAAAATGATTTTCCCTTTGCAGGTTGCACACAGTTTTGTTTATGCATTTCCTTAAAATTAATTGTAGACTCCAGGATAC
AAACCATAGTAGGCAATACAATTTTAGAATGTAATATATAGAGGTATATTTAGCCTCTTTTAGAAGTCAGTGGATTGAATGTCTTTTTAT
TTTAAATTTTACATTCATTAAGGTGCCTCGTTTTTGACTTTGTCCATTAACATTTATCCATATGCCTTTGCAATAACTAGATTGTGAAAA

>3723_3723_3_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000469224_SRPK2_chr7_104758469_ENST00000357311_length(amino acids)=194AA_BP=
MNMESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKTAKAKVQQTPDGSQQSPDG
TQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQR

--------------------------------------------------------------
>3723_3723_4_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000484952_SRPK2_chr7_104758469_ENST00000357311_length(transcript)=2544nt_BP=898nt
CGGCGATCGCGGCCTGAGGCTGCTCCCGGACAAGGGCAACGAGCGTTTCGTTTGGACTTCTCGACTTGAGTGCCCGCCTCCTTCGCCGCC
GCCTCTGCAGTCCTCAGCGCAGTTATGCCCAGTTCTTCCCGCTGTGGGGACACGACCACGGAGGAATCCTTGCTTCAGGGACTCGGGACC
CTGCTGGACCCCTTCCTCGGGTTTAGGGGATGTGGGGACCAGGAGAAAGTCAGGATCCCTAAGAGTCTTCCCTGCCTGGATGGATGAGTG
GCTTCTTCTCCACCTAGATTCTTTCCACAGGAGCCAGCATACTTCCTGAACATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATCCCGA
GTCCCCCAGGCCTTTCTGCAGAAAGCAGGCAAATCTCTGTTGTTCTATGCCCAAAACTGCCCCAAGATGATGGAAGTTGGGGCCAAGCCA
GCCCCTCGGGCATTGTCCACTGCAGCAGTACACTACCAACAGATCAAAGAAACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAAGGCC
AAGGTCCAACAGACTCCTGATGGATCCCAGCAGAGTCCAGATGGCACACAGCTTCCGTCTGGACACCCCTTGCCTGCCACAAGCCAGGGC
ACTGCAAGCAAATGCCCTTTCCTGGCAGCACAGATGAATCAGAGAGGCAGCAGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGAGGAT
GTGCAGGAAATGAATGCCGTGAGGAAAGAGGTTGCTGAAACCTCAGCAGGCCCCAGTGTGGTTAGTGTGAAAACCGATGGAGGGGATCCC
AGTGGACTGCTGAAGAACTTCCAGGACATCATGCAAAAGCAAAGACCAGAAAGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAAATGA
GAACTGCGACACATCACCAAGCTGAAGCCCTGGAGCCTCTTTGATGTACTTGTGGAAAAGTATGGCTGGCCCCATGAAGATGCTGCACAG
TTTACAGATTTCCTGATCCCGATGTTAGAAATGGTTCCAGAAAAACGAGCCTCAGCTGGCGAATGCCTTCGGCATCCTTGGTTGAATTCT
TAGCAAATTCTACCAATATTGCATTCTGAGCTAGCAAATGTTCCCAGTACATTGGACCTAAACGGTGACTCTCATTCTTTAACAGGATTA
CAAGTGAGCTGGCTTCATCCTCAGACCTTTATTTTGCTTTGAGGTACTGTTGTTTGACATTTTGCTTTTTGTGCACTGTGATCCTGGGGA
AGGGTAGTCTTTTGTCTTCAGCTAAGTAGTTTACTGACCATTTTCTTCTGGAAACAATAACATGTCTCTAAGCATTGTTTCTTGTGTTGT
GTGACATTCAAATGTCATTTTTTTGAATGAAAAATACTTTCCCCTTTGTGTTTTGGCAGGTTTTGTAACTATTTATGAAGAAATATTTTA
GCTGAGTACTATATAATTTACAATCTTAAGAAATTATCAAGTTGGAACCAAGAAATAGCAAGGAAATGTACAATTTTATCTTCTGGCAAA
GGGACATCATTCCTGTATTATAGTGTATGTAAATGCACCCTGTAAATGTTACTTTCCATTAAATATGGGAGGGGGACTCAAATTTCAGAA
AAGCTACCAAGTCTTGAGTGCTTTGTAGCCTATGTTGCATGTAGCGGACTTTAACTGCTCCAAGGAGTTGTGCAAACTTTTCATTCCATA
ACAGTCTTTTCACATTGGATTTTAAACAAAGTGGCTCTGGGTTATAAGATGTCATTCTCTATATGGCACTTTAAAGGAAGAAAAGATATG
TTTCTCATTCTAAAATATGCATTATAATTTAGCAGTCCCATTTGTGATTTTGCATATTTTTAAAAGTACTTTTAAAGAAGAGCAATTTCC
CTTTAAAAATGTGATGGCTCAGTACCATGTCATGTTGCCTCCTCTGGGCGCTGTAAGTTAAGCTCTACATAGATTAAATTGGAGAAACGT
GTTAATTGTGTGGAATGAAAAAATACATATATTTTTGGAAAAGCATGATCATGCTTGTCTAGAACACAAGGTATGGTATATACAATTTGC
AGTGCAGTGGGCAGAATACTTCTCACAGCTCAAAGATAACAGTGATCACATTCATTCCATAGGTAGCTTTACGTGTGGCTACAACAAATT
TTACTAGCTTTTTCATTGTCTTTCCATGAAACGAAGTTGAGAAAATGATTTTCCCTTTGCAGGTTGCACACAGTTTTGTTTATGCATTTC
CTTAAAATTAATTGTAGACTCCAGGATACAAACCATAGTAGGCAATACAATTTTAGAATGTAATATATAGAGGTATATTTAGCCTCTTTT
AGAAGTCAGTGGATTGAATGTCTTTTTATTTTAAATTTTACATTCATTAAGGTGCCTCGTTTTTGACTTTGTCCATTAACATTTATCCAT
ATGCCTTTGCAATAACTAGATTGTGAAAAGCTAACAAGTGTTGTAACAATAATCCATTGTTTGAGGTGCTTGCAGTTGTCTTAAAAATTA

>3723_3723_4_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000484952_SRPK2_chr7_104758469_ENST00000357311_length(amino acids)=194AA_BP=
MNMESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKTAKAKVQQTPDGSQQSPDG
TQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ALAS1-SRPK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ALAS1-SRPK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ALAS1-SRPK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source