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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HNRNPL-ACTN4 (FusionGDB2 ID:37241)

Fusion Gene Summary for HNRNPL-ACTN4

Fusion gene summary

Fusion gene information	Fusion gene name: HNRNPL-ACTN4
	Fusion gene ID: 37241
		Hgene	Tgene
	Gene symbol	HNRNPL	ACTN4
	Gene ID	3191	81
	Gene name	heterogeneous nuclear ribonucleoprotein L	actinin alpha 4
	Synonyms	HNRPL\|P/OKcl.14\|hnRNP-L	ACTININ-4\|FSGS\|FSGS1
	Cytomap	19q13.2	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	heterogeneous nuclear ribonucleoprotein Lepididymis secretory sperm binding proteinhnRNP L	alpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4
	Modification date	20200313	20200327
	UniProtAcc	P14866	O43707
	Ensembl transtripts involved in fusion gene	ENST00000221419, ENST00000600873,	ENST00000390009, ENST00000424234, ENST00000497637, ENST00000252699,
Fusion gene scores	* DoF score	17 X 19 X 9=2907	27 X 38 X 12=12312
	# samples	19	48
	** MAII score	log2(19/2907*10)=-3.93545974780529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(48/12312*10)=-4.68088692071969 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HNRNPL [Title/Abstract] AND ACTN4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HNRNPL(39340340)-ACTN4(39205109), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ACTN4	GO:0033209	tumor necrosis factor-mediated signaling pathway	25411248
Tgene	ACTN4	GO:0035357	peroxisome proliferator activated receptor signaling pathway	22351778
Tgene	ACTN4	GO:0048384	retinoic acid receptor signaling pathway	22351778
Tgene	ACTN4	GO:0051272	positive regulation of cellular component movement	9508771

Fusion gene breakpoints across HNRNPL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACTN4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-23-1107-01A	HNRNPL	chr19	39340340	-	ACTN4	chr19	39205109	+

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Fusion Gene ORF analysis for HNRNPL-ACTN4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000221419	ENST00000390009	HNRNPL	chr19	39340340	-	ACTN4	chr19	39205109	+
5CDS-intron	ENST00000221419	ENST00000424234	HNRNPL	chr19	39340340	-	ACTN4	chr19	39205109	+
5CDS-intron	ENST00000221419	ENST00000497637	HNRNPL	chr19	39340340	-	ACTN4	chr19	39205109	+
In-frame	ENST00000221419	ENST00000252699	HNRNPL	chr19	39340340	-	ACTN4	chr19	39205109	+
intron-3CDS	ENST00000600873	ENST00000252699	HNRNPL	chr19	39340340	-	ACTN4	chr19	39205109	+
intron-intron	ENST00000600873	ENST00000390009	HNRNPL	chr19	39340340	-	ACTN4	chr19	39205109	+
intron-intron	ENST00000600873	ENST00000424234	HNRNPL	chr19	39340340	-	ACTN4	chr19	39205109	+
intron-intron	ENST00000600873	ENST00000497637	HNRNPL	chr19	39340340	-	ACTN4	chr19	39205109	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000221419

HNRNPL

chr19

39340340

ENST00000252699

ACTN4

chr19

39205109

4702

634

367

2550

727

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000221419	ENST00000252699	HNRNPL	chr19	39340340	-	ACTN4	chr19	39205109	+	0.012919731	0.9870803

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Fusion Genomic Features for HNRNPL-ACTN4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HNRNPL	chr19	39340339	-	ACTN4	chr19	39205108	+	5.15E-16	1
HNRNPL	chr19	39340339	-	ACTN4	chr19	39205108	+	5.15E-16	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HNRNPL-ACTN4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:39340340/chr19:39205109)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HNRNPL P14866	ACTN4 O43707
FUNCTION: Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). {ECO:0000269\|PubMed:11809897, ECO:0000269\|PubMed:22570490, ECO:0000269\|PubMed:25623890, ECO:0000269\|PubMed:26051023, ECO:0000269\|PubMed:2687284}.	FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). {ECO:0000250\|UniProtKB:P57780, ECO:0000269\|PubMed:15772161, ECO:0000269\|PubMed:22351778, ECO:0000305\|PubMed:9508771}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HNRNPL

chr19:39340340

chr19:39205109

ENST00000221419

39_89

590.0

Compositional bias

Note=Gly-rich

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

778_789

273

912.0

Calcium binding

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

819_830

273

912.0

Calcium binding

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

778_789

693.0

Calcium binding

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

819_830

693.0

Calcium binding

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

765_800

273

912.0

Domain

EF-hand 1

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

806_841

273

912.0

Domain

EF-hand 2

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

163_269

693.0

Domain

Calponin-homology (CH) 2

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

765_800

693.0

Domain

EF-hand 1

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

806_841

693.0

Domain

EF-hand 2

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

84_88

693.0

Motif

LXXLL motif

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

177_192

693.0

Region

Polyphosphoinositide (PIP2)-binding

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

293_403

273

912.0

Repeat

Spectrin 1

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

413_518

273

912.0

Repeat

Spectrin 2

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

528_639

273

912.0

Repeat

Spectrin 3

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

649_752

273

912.0

Repeat

Spectrin 4

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

293_403

693.0

Repeat

Spectrin 1

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

413_518

693.0

Repeat

Spectrin 2

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

528_639

693.0

Repeat

Spectrin 3

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

649_752

693.0

Repeat

Spectrin 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HNRNPL

chr19:39340340

chr19:39205109

ENST00000221419

335_382

590.0

Compositional bias

Note=Pro-rich

Hgene

HNRNPL

chr19:39340340

chr19:39205109

ENST00000600873

335_382

457.0

Compositional bias

Note=Pro-rich

Hgene

HNRNPL

chr19:39340340

chr19:39205109

ENST00000600873

39_89

457.0

Compositional bias

Note=Gly-rich

Hgene

HNRNPL

chr19:39340340

chr19:39205109

ENST00000221419

102_176

590.0

Domain

RRM 1

Hgene

HNRNPL

chr19:39340340

chr19:39205109

ENST00000221419

193_270

590.0

Domain

RRM 2

Hgene

HNRNPL

chr19:39340340

chr19:39205109

ENST00000221419

382_478

590.0

Domain

RRM 3

Hgene

HNRNPL

chr19:39340340

chr19:39205109

ENST00000221419

495_583

590.0

Domain

RRM 4

Hgene

HNRNPL

chr19:39340340

chr19:39205109

ENST00000600873

102_176

457.0

Domain

RRM 1

Hgene

HNRNPL

chr19:39340340

chr19:39205109

ENST00000600873

193_270

457.0

Domain

RRM 2

Hgene

HNRNPL

chr19:39340340

chr19:39205109

ENST00000600873

382_478

457.0

Domain

RRM 3

Hgene

HNRNPL

chr19:39340340

chr19:39205109

ENST00000600873

495_583

457.0

Domain

RRM 4

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

19_26

273

912.0

Compositional bias

Poly-Gly

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

19_26

693.0

Compositional bias

Poly-Gly

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

163_269

273

912.0

Domain

Calponin-homology (CH) 2

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

50_154

273

912.0

Domain

Calponin-homology (CH) 1

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

50_154

693.0

Domain

Calponin-homology (CH) 1

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

84_88

273

912.0

Motif

LXXLL motif

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

177_192

273

912.0

Region

Polyphosphoinositide (PIP2)-binding

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000252699

1_269

273

912.0

Region

Note=Actin-binding

Tgene

ACTN4

chr19:39340340

chr19:39205109

ENST00000390009

1_269

693.0

Region

Note=Actin-binding

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Fusion Gene Sequence for HNRNPL-ACTN4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>37241_37241_1_HNRNPL-ACTN4_HNRNPL_chr19_39340340_ENST00000221419_ACTN4_chr19_39205109_ENST00000252699_length(transcript)=4702nt_BP=634nt
GGAGACCAATGAAAGTGGGAGGGAGGCGGAGATTCTTGGGAGGTTTAGAGCGCCGTTCCTATCAGGTGCTTTTAGGGAGGCCAGCAGCGC
CAGAAATCCGACCTATCAAATTGGATTTTATTTTAAGGCGGCGGGGTCGACGGAAAGACTGGCAGAAAGCGACCACCTATAAGGAGTGTC
TCAGACAAACAAGGGCGGGCCCTCCTGCAGAACGGCGTGGGCAATGTCCAATAAGCGCGCAAGGCGTGTGGCGGCCTACCCTCCCCCCGC
GGCGGGACCAGTGGCTCCCCCTATCGGGTGGGGGCGGCGGGTGACGGGCGTGTCCCTCCCCCAATGAGAGGCGGGGGGAGGCGGGTTCTG
CGCCGCCATGTCGCGGAGGCTGCTGCCCCGGGCGGAGAAGCGGCGTCGGCGGCTGGAGCAGAGGCAGCAGCCGGACGAGCAGCGGAGGCG
GTCGGGAGCGATGGTGAAGATGGCGGCGGCGGGCGGCGGAGGCGGCGGTGGCCGCTACTACGGCGGCGGCAGTGAGGGCGGCCGGGCCCC
TAAGCGGCTCAAGACTGACAACGCCGGCGACCAGCACGGAGGCGGCGGCGGTGGCGGTGGAGGAGCCGGGGCGGCGGGCGGCGGCGGCGG
TGGGGCTGAAACTGCCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGC
CAGCGACCTCCTGGAGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCT
GGAGGACTTCCGCGACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGAC
CAAGCTGCGCCTCAGCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGACATCAACAATGGCTGGCAGCACTTGGAGCA
GGCTGAGAAGGGCTACGAGGAGTGGCTGCTGAATGAGATCCGCAGGCTGGAGCGGCTCGACCACCTGGCAGAGAAGTTCCGGCAGAAGGC
CTCCATCCACGAGGCCTGGACTGACGGGAAGGAAGCCATGCTGAAGCACCGGGACTACGAGACGGCCACACTATCGGACATCAAAGCCCT
CATTCGCAAGCACGAGGCCTTCGAGAGCGACCTGGCTGCGCACCAGGACCGCGTGGAGCAGATCGCCGCCATTGCCCAGGAGCTCAACGA
GCTGGATTACTACGACTCCCACAATGTCAACACCCGGTGCCAGAAGATCTGTGACCAGTGGGACGCCCTCGGCTCTCTGACACATAGTCG
CAGGGAAGCCCTGGAGAAAACAGAGAAGCAGCTGGAGGCCATCGACCAGCTGCACCTGGAATACGCCAAGCGCGCGGCCCCCTTCAACAA
CTGGATGGAGAGCGCCATGGAGGACCTCCAGGACATGTTCATCGTCCATACCATCGAGGAGATTGAGGGCCTGATCTCAGCCCATGACCA
GTTCAAGTCCACCCTGCCGGACGCCGATAGGGAGCGCGAGGCCATCCTGGCCATCCACAAGGAGGCCCAGAGGATCGCTGAGAGCAACCA
CATCAAGCTGTCGGGCAGCAACCCCTACACCACCGTCACCCCGCAAATCATCAACTCCAAGTGGGAGAAGGTGCAGCAGCTGGTGCCAAA
ACGGGACCATGCCCTCCTGGAGGAGCAGAGCAAGCAGCAGTCCAACGAGCACCTGCGCCGCCAGTTCGCCAGCCAGGCCAATGTTGTGGG
GCCCTGGATCCAGACCAAGATGGAGGAGATCGGGCGCATCTCCATTGAGATGAACGGGACCCTGGAGGACCAGCTGAGCCACCTGAAGCA
GTATGAACGCAGCATCGTGGACTACAAGCCCAACCTGGACCTGCTGGAGCAGCAGCACCAGCTCATCCAGGAGGCCCTCATCTTCGACAA
CAAGCACACCAACTATACCATGGAGCACATCCGCGTGGGCTGGGAGCAGCTGCTCACCACCATTGCCCGCACCATCAACGAGGTGGAGAA
CCAGATCCTCACCCGCGACGCCAAGGGCATCAGCCAGGAGCAGATGCAGGAGTTCCGGGCGTCCTTCAACCACTTCGACAAGGATCATGG
CGGGGCGCTGGGGCCCGAGGAGTTCAAGGCCTGCCTCATCAGCCTGGGCTACGACGTGGAGAACGACCGGCAGGGTGAGGCCGAGTTCAA
CCGCATCATGAGCCTGGTCGACCCCAACCATAGCGGCCTTGTGACCTTCCAAGCCTTCATCGACTTCATGTCGCGGGAGACCACCGACAC
GGACACGGCTGACCAGGTCATCGCTTCCTTCAAGGTCTTAGCAGGGGACAAGAACTTCATCACAGCTGAGGAGCTGCGGAGAGAGCTGCC
CCCCGACCAGGCCGAGTACTGCATCGCCCGCATGGCGCCATACCAGGGCCCTGACGCCGTGCCCGGTGCCCTCGACTACAAGTCCTTCTC
CACGGCCTTGTATGGCGAGAGCGACCTGTGAGGCCCCAGAGACCTGACCCAACACCCCCGACGGCCTCCAGGAGGGGCCTGGGCAGCCCC
ACAGTCCCATTCCTCCACTCTGTATCTATGCAAAGCACTCTCTGCAGTCCTCCGGGGTGGGTGGGTGGGCAGGGAGGGGCTGGGGCAGGC
TCTCTCCTCTCTCTCTTTGTGGGTTGGCCAGGAGGTTCCCCCGACCAGGTTGGGGAGACTTGGGGCCAGCGCTTCTGGTCTGGTAAATAT
GTATGATGTGTTGTGCTTTTTTAACCAAGGAGGGGCCAGTGGATTCCCACAGCACAACCGGTCCCTTCCATGCCCTGGGATGCCTCACCA
CACCCAGGTCTCTTCCTTTGCTCTGAGGTCCCTTCAAGGCCTCCCCAATCCAGGCCAAAGCCCCATGTGCCTTGTCCAGGAACTGCCTGG
GCCATGCGAGGGGCCAGCAGAGGGCGCCACCACCACCTGACGGCTGGGGACCCACCCAGCCCCTCTCCCCTCTCTGCTCCAGACTCACTT
GCCATTGCCAGGAGATGGCCCCAACAAGCACCCCGCTTTTGCAGCAGAGGAGCTGAGTTGGCAGACCGGGCCCCCCTGAACCGCACCCCA
TCCCACCAGCCCCGGCCTTGCTTTGTCTGGCCTCACGTGTCTCAGATTTTCTAAGAACCAAAAAAAAAAAAGGAAAAAAAACACAAAACA
ACAAAAACCAAAAAAAAAAAAAATCACAAAAACAAAAAAACTATAAAAAAGAAAGAATTAAAAACTTTCAGAGAATTACTATTTACTTTA
TTAACTTACGGATTTATTATATAAATATATATTCACCTAGCAACATATCTCTGCCGTCTCTCCTGCTCTCATAATGAAGACATAGCCGAT
TCTCTGCCCGGGCCCCTTGCTGATGCTCCTCCGGGTCTGCGTCGGGCGTGGGTCTCTGGGGACCCTCCAGAGGTGGAGGTGGGCTGATGG
CCTGGCTGCCTGGTGGTTGATGGTTTTGCTCCCCCTACCTTTTTTTTTTGAGTTTATTCTGATTGATTTTTTTTCTTGGTTTCTGGATAA
ACCACCCTCTGGGGACAGGATAATAAAACATGTAATATTTTTAAGAAGGATTCCTGCAGCATCATCTTTTTTTATTTCTCCTGTGTCTGT
CCTCCACCTTCTAGGAGAGCCAGGGCAGAGCTAGCACTGTCTTAAGCTGTCAACGTGGACTAGCTCGTGTCATCTGCTCGAGAAGGGCTG
TCGCTGTTCTTGTTTCTGAGTGAGGAGTACGCAGGCCAGAGTGGTCACCCGGCCGTGAGCAGTGAGGGCCAGAGACTAGCCCCAGACAGG
TGGATGCCAGAGAGAGTGGCACCCATGCCAGGCAAGGCCTAGGGAGGTGGTCTTGCTCAGCAACCCTGCCCTGAGCAGCAGGTGCGCCCA
TCCGGAGATCCTAGGAGAAGGTGGCCACCTCCATCCACTAAGGAAGAGAAGGAAGACAGTGGCTTGAGGCAGGGAGCTCGCAGGACAGAG
CCTGAGCCACCCTGTCCCTCCCACCTGGCTCACCTGTCTGTGGGTCAGGCAGATGACCCCCTCACCCCCATCCAGGTGCTGGCTGCAGTG
GCCTGTGCAGAGAGGGGCAGGGTGAGTGCCCACCAGTCCCCGTACCCCTTCCCCCCATGCCCCACCATGCCGGGGTGGTACTCACAGAAG
ATGCAGGTGAGGTGGGCCACACAGGACACGAACCGCTCGAAGTCCACACGCAGACGGCTATCCCGGTAGCGGCTGGTGAGGGTCTGGGTC
AGCTGGTTGTTCAGGTGGAAGCCTAGGGGGAGGCTGCTTCTGAGCCCAGTGGCCCACAGGGAACCCACCTTGGCATTGCATCCCCACCCC
ACCTCCTCAGGGAGGACATGAATGCCACAGGGTGTCACACCCCAACTCTGCCCCATCCCGGCAGGGTGAGTACAGGCTGATCCCTTCAAT
CCTCTGGGCCTGTTTCCTCATCCATCAAACGGACTAAGACAGCCCCGACCCCATAGGGTGTGTGAAGACAGAACGCTCAGGACAGCGTCT
GACACGTGACTCGATGTGTGGGTACTGTTACTCCTTAAATCCTGTGGGGCTTTCTCCTTGCCAGTGGGCACTGGAGGATATTTCTGTGCA

>37241_37241_1_HNRNPL-ACTN4_HNRNPL_chr19_39340340_ENST00000221419_ACTN4_chr19_39205109_ENST00000252699_length(amino acids)=727AA_BP=65
MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGGA
ETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKL
RLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIR
KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWM
ESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRD
HALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKH
TNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRI
MSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTA

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Fusion Gene PPI Analysis for HNRNPL-ACTN4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	ACTN4	chr19:39340340	chr19:39205109	ENST00000390009		0	14	108_126	54.0	693.0	VCL

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	ACTN4	chr19:39340340	chr19:39205109	ENST00000252699		7	21	108_126	273.0	912.0	VCL
Tgene	ACTN4	chr19:39340340	chr19:39205109	ENST00000252699		7	21	12_26	273.0	912.0	VCL
Tgene	ACTN4	chr19:39340340	chr19:39205109	ENST00000252699		7	21	40_61	273.0	912.0	VCL
Tgene	ACTN4	chr19:39340340	chr19:39205109	ENST00000390009		0	14	12_26	54.0	693.0	VCL
Tgene	ACTN4	chr19:39340340	chr19:39205109	ENST00000390009		0	14	40_61	54.0	693.0	VCL

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HNRNPL-ACTN4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HNRNPL-ACTN4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source