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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HNRNPUL1-FOS (FusionGDB2 ID:37312)

Fusion Gene Summary for HNRNPUL1-FOS

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPUL1-FOS
Fusion gene ID: 37312
HgeneTgene
Gene symbol

HNRNPUL1

FOS

Gene ID

11100

2353

Gene nameheterogeneous nuclear ribonucleoprotein U like 1Fos proto-oncogene, AP-1 transcription factor subunit
SynonymsE1B-AP5|E1BAP5|HNRPUL1AP-1|C-FOS|p55
Cytomap

19q13.2

14q24.3

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein U-like protein 1E1B 55kDa associated protein 5E1B-55 kDa-associated protein 5adenovirus early region 1B-associated protein 5proto-oncogene c-FosFBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)FBJ murine osteosarcoma viral oncogene homologFos proto-oncogene, AP-1 trancription factor subunitG0/G1 switch regulatory protein 7activator protein 1cellular o
Modification date2020032720200329
UniProtAcc

Q9BUJ2

P15408

Ensembl transtripts involved in fusion geneENST00000263367, ENST00000352456, 
ENST00000378215, ENST00000392006, 
ENST00000593587, ENST00000595018, 
ENST00000602130, ENST00000594207, 
ENST00000303562, ENST00000535987, 
ENST00000554617, ENST00000555242, 
ENST00000555347, ENST00000555686, 
ENST00000556324, 
Fusion gene scores* DoF score18 X 14 X 12=302410 X 13 X 3=390
# samples 2013
** MAII scorelog2(20/3024*10)=-3.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/390*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HNRNPUL1 [Title/Abstract] AND FOS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHNRNPUL1(41798202)-FOS(75748847), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFOS

GO:0007179

transforming growth factor beta receptor signaling pathway

9732876

TgeneFOS

GO:0034614

cellular response to reactive oxygen species

17217916

TgeneFOS

GO:0045893

positive regulation of transcription, DNA-templated

9732876

TgeneFOS

GO:0045944

positive regulation of transcription by RNA polymerase II

10508860

TgeneFOS

GO:0060395

SMAD protein signal transduction

9732876


check buttonFusion gene breakpoints across HNRNPUL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FOS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AEC513528HNRNPUL1chr19

41798202

+FOSchr14

75748847

+


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Fusion Gene ORF analysis for HNRNPUL1-FOS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000263367ENST00000303562HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-3UTRENST00000352456ENST00000303562HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-3UTRENST00000378215ENST00000303562HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-3UTRENST00000392006ENST00000303562HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-3UTRENST00000593587ENST00000303562HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-3UTRENST00000595018ENST00000303562HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-3UTRENST00000602130ENST00000303562HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000263367ENST00000535987HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000263367ENST00000554617HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000263367ENST00000555242HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000263367ENST00000555347HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000263367ENST00000555686HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000263367ENST00000556324HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000352456ENST00000535987HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000352456ENST00000554617HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000352456ENST00000555242HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000352456ENST00000555347HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000352456ENST00000555686HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000352456ENST00000556324HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000378215ENST00000535987HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000378215ENST00000554617HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000378215ENST00000555242HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000378215ENST00000555347HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000378215ENST00000555686HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000378215ENST00000556324HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000392006ENST00000535987HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000392006ENST00000554617HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000392006ENST00000555242HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000392006ENST00000555347HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000392006ENST00000555686HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000392006ENST00000556324HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000593587ENST00000535987HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000593587ENST00000554617HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000593587ENST00000555242HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000593587ENST00000555347HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000593587ENST00000555686HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000593587ENST00000556324HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000595018ENST00000535987HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000595018ENST00000554617HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000595018ENST00000555242HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000595018ENST00000555347HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000595018ENST00000555686HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000595018ENST00000556324HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000602130ENST00000535987HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000602130ENST00000554617HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000602130ENST00000555242HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000602130ENST00000555347HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000602130ENST00000555686HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
5CDS-intronENST00000602130ENST00000556324HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
intron-3UTRENST00000594207ENST00000303562HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
intron-intronENST00000594207ENST00000535987HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
intron-intronENST00000594207ENST00000554617HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
intron-intronENST00000594207ENST00000555242HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
intron-intronENST00000594207ENST00000555347HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
intron-intronENST00000594207ENST00000555686HNRNPUL1chr19

41798202

+FOSchr14

75748847

+
intron-intronENST00000594207ENST00000556324HNRNPUL1chr19

41798202

+FOSchr14

75748847

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HNRNPUL1-FOS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HNRNPUL1-FOS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:41798202/:75748847)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPUL1

Q9BUJ2

FOS

P15408

FUNCTION: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}.FUNCTION: Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HNRNPUL1-FOS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HNRNPUL1-FOS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HNRNPUL1-FOS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HNRNPUL1-FOS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource