FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:HOOK3-IKBKB (FusionGDB2 ID:37391)

Fusion Gene Summary for HOOK3-IKBKB

check button Fusion gene summary
Fusion gene informationFusion gene name: HOOK3-IKBKB
Fusion gene ID: 37391
HgeneTgene
Gene symbol

HOOK3

IKBKB

Gene ID

84376

3551

Gene namehook microtubule tethering protein 3inhibitor of nuclear factor kappa B kinase subunit beta
SynonymsHK3IKK-beta|IKK2|IKKB|IMD15|IMD15A|IMD15B|NFKBIKB
Cytomap

8p11.21

8p11.21

Type of geneprotein-codingprotein-coding
Descriptionprotein Hook homolog 3h-hook3hHK3hook homolog 3inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B kinase 2I-kappa-B-kinase betainhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betanuclear factor NF-kappa-B inhibitor kinase beta
Modification date2020031320200313
UniProtAcc.

O14920

Ensembl transtripts involved in fusion geneENST00000307602, ENST00000524839, 
ENST00000379708, ENST00000518983, 
ENST00000522147, ENST00000522785, 
ENST00000416505, ENST00000519735, 
ENST00000520810, ENST00000520835, 
Fusion gene scores* DoF score16 X 13 X 9=187211 X 14 X 4=616
# samples 1914
** MAII scorelog2(19/1872*10)=-3.30050911125246
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/616*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HOOK3 [Title/Abstract] AND IKBKB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHOOK3(42798588)-IKBKB(42162705), # samples:3
Anticipated loss of major functional domain due to fusion event.HOOK3-IKBKB seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
HOOK3-IKBKB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HOOK3-IKBKB seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
HOOK3-IKBKB seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HOOK3-IKBKB seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIKBKB

GO:0006468

protein phosphorylation

15084260|20434986

TgeneIKBKB

GO:0018105

peptidyl-serine phosphorylation

21399639

TgeneIKBKB

GO:0042325

regulation of phosphorylation

26212789

TgeneIKBKB

GO:0045944

positive regulation of transcription by RNA polymerase II

23091055|23453807

TgeneIKBKB

GO:0051092

positive regulation of NF-kappaB transcription factor activity

15790681

TgeneIKBKB

GO:0071356

cellular response to tumor necrosis factor

23091055


check buttonFusion gene breakpoints across HOOK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IKBKB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0D1-01AHOOK3chr8

42798588

+IKBKBchr8

42150961

+
ChimerDB4BRCATCGA-A2-A0D1-01AHOOK3chr8

42798588

-IKBKBchr8

42162705

+
ChimerDB4BRCATCGA-A2-A0D1-01AHOOK3chr8

42798588

+IKBKBchr8

42162705

+


Top

Fusion Gene ORF analysis for HOOK3-IKBKB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000307602ENST00000379708HOOK3chr8

42798588

+IKBKBchr8

42150961

+
5CDS-intronENST00000307602ENST00000379708HOOK3chr8

42798588

+IKBKBchr8

42162705

+
5CDS-intronENST00000307602ENST00000518983HOOK3chr8

42798588

+IKBKBchr8

42150961

+
5CDS-intronENST00000307602ENST00000518983HOOK3chr8

42798588

+IKBKBchr8

42162705

+
5CDS-intronENST00000307602ENST00000522147HOOK3chr8

42798588

+IKBKBchr8

42150961

+
5CDS-intronENST00000307602ENST00000522147HOOK3chr8

42798588

+IKBKBchr8

42162705

+
5CDS-intronENST00000307602ENST00000522785HOOK3chr8

42798588

+IKBKBchr8

42150961

+
5CDS-intronENST00000307602ENST00000522785HOOK3chr8

42798588

+IKBKBchr8

42162705

+
Frame-shiftENST00000307602ENST00000416505HOOK3chr8

42798588

+IKBKBchr8

42150961

+
Frame-shiftENST00000307602ENST00000519735HOOK3chr8

42798588

+IKBKBchr8

42150961

+
Frame-shiftENST00000307602ENST00000520810HOOK3chr8

42798588

+IKBKBchr8

42150961

+
Frame-shiftENST00000307602ENST00000520835HOOK3chr8

42798588

+IKBKBchr8

42150961

+
In-frameENST00000307602ENST00000416505HOOK3chr8

42798588

+IKBKBchr8

42162705

+
In-frameENST00000307602ENST00000519735HOOK3chr8

42798588

+IKBKBchr8

42162705

+
In-frameENST00000307602ENST00000520810HOOK3chr8

42798588

+IKBKBchr8

42162705

+
In-frameENST00000307602ENST00000520835HOOK3chr8

42798588

+IKBKBchr8

42162705

+
intron-3CDSENST00000524839ENST00000416505HOOK3chr8

42798588

+IKBKBchr8

42150961

+
intron-3CDSENST00000524839ENST00000416505HOOK3chr8

42798588

+IKBKBchr8

42162705

+
intron-3CDSENST00000524839ENST00000519735HOOK3chr8

42798588

+IKBKBchr8

42150961

+
intron-3CDSENST00000524839ENST00000519735HOOK3chr8

42798588

+IKBKBchr8

42162705

+
intron-3CDSENST00000524839ENST00000520810HOOK3chr8

42798588

+IKBKBchr8

42150961

+
intron-3CDSENST00000524839ENST00000520810HOOK3chr8

42798588

+IKBKBchr8

42162705

+
intron-3CDSENST00000524839ENST00000520835HOOK3chr8

42798588

+IKBKBchr8

42150961

+
intron-3CDSENST00000524839ENST00000520835HOOK3chr8

42798588

+IKBKBchr8

42162705

+
intron-intronENST00000524839ENST00000379708HOOK3chr8

42798588

+IKBKBchr8

42150961

+
intron-intronENST00000524839ENST00000379708HOOK3chr8

42798588

+IKBKBchr8

42162705

+
intron-intronENST00000524839ENST00000518983HOOK3chr8

42798588

+IKBKBchr8

42150961

+
intron-intronENST00000524839ENST00000518983HOOK3chr8

42798588

+IKBKBchr8

42162705

+
intron-intronENST00000524839ENST00000522147HOOK3chr8

42798588

+IKBKBchr8

42150961

+
intron-intronENST00000524839ENST00000522147HOOK3chr8

42798588

+IKBKBchr8

42162705

+
intron-intronENST00000524839ENST00000522785HOOK3chr8

42798588

+IKBKBchr8

42150961

+
intron-intronENST00000524839ENST00000522785HOOK3chr8

42798588

+IKBKBchr8

42162705

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000307602HOOK3chr842798588+ENST00000520810IKBKBchr842162705+31126001822482766
ENST00000307602HOOK3chr842798588+ENST00000416505IKBKBchr842162705+26366001822482766
ENST00000307602HOOK3chr842798588+ENST00000519735IKBKBchr842162705+1208600182982266
ENST00000307602HOOK3chr842798588+ENST00000520835IKBKBchr842162705+25686001822482766

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000307602ENST00000520810HOOK3chr842798588+IKBKBchr842162705+0.003136040.99686396
ENST00000307602ENST00000416505HOOK3chr842798588+IKBKBchr842162705+0.0058030030.994197
ENST00000307602ENST00000519735HOOK3chr842798588+IKBKBchr842162705+0.004923990.995076
ENST00000307602ENST00000520835HOOK3chr842798588+IKBKBchr842162705+0.0054316530.99456835

Top

Fusion Genomic Features for HOOK3-IKBKB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HOOK3chr842798588+IKBKBchr842150960+2.95E-050.99997056
HOOK3chr842798588+IKBKBchr842162704+2.11E-101
HOOK3chr842798588+IKBKBchr842150960+2.95E-050.99997056
HOOK3chr842798588+IKBKBchr842162704+2.11E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for HOOK3-IKBKB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:42798588/chr8:42162705)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IKBKB

O14920

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:30337470). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:20410276). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NCOA3, BCL10 and IRS1 (PubMed:17213322). Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (PubMed:11297557). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHOOK3chr8:42798588chr8:42162705ENST00000307602+52210_126133719.0DomainCalponin-homology (CH)
TgeneIKBKBchr8:42798588chr8:42162705ENST00000416505321458_47970698.0RegionNote=Leucine-zipper
TgeneIKBKBchr8:42798588chr8:42162705ENST00000416505321737_74270698.0RegionNote=NEMO-binding
TgeneIKBKBchr8:42798588chr8:42162705ENST0000051973549458_479129257.0RegionNote=Leucine-zipper
TgeneIKBKBchr8:42798588chr8:42162705ENST0000051973549737_742129257.0RegionNote=NEMO-binding
TgeneIKBKBchr8:42798588chr8:42162705ENST00000520810422458_479129757.0RegionNote=Leucine-zipper
TgeneIKBKBchr8:42798588chr8:42162705ENST00000520810422737_742129757.0RegionNote=NEMO-binding
TgeneIKBKBchr8:42798588chr8:42162705ENST00000520835321458_479127755.0RegionNote=Leucine-zipper
TgeneIKBKBchr8:42798588chr8:42162705ENST00000520835321737_742127755.0RegionNote=NEMO-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHOOK3chr8:42798588chr8:42162705ENST00000307602+522167_433133719.0Coiled coilOntology_term=ECO:0000255
HgeneHOOK3chr8:42798588chr8:42162705ENST00000307602+522462_667133719.0Coiled coilOntology_term=ECO:0000255
HgeneHOOK3chr8:42798588chr8:42162705ENST00000307602+522553_718133719.0RegionNote=Required for association with Golgi
TgeneIKBKBchr8:42798588chr8:42162705ENST0000041650532115_30070698.0DomainProtein kinase
TgeneIKBKBchr8:42798588chr8:42162705ENST000005197354915_300129257.0DomainProtein kinase
TgeneIKBKBchr8:42798588chr8:42162705ENST0000052081042215_300129757.0DomainProtein kinase
TgeneIKBKBchr8:42798588chr8:42162705ENST0000052083532115_300127755.0DomainProtein kinase
TgeneIKBKBchr8:42798588chr8:42162705ENST0000041650532121_2970698.0Nucleotide bindingATP
TgeneIKBKBchr8:42798588chr8:42162705ENST000005197354921_29129257.0Nucleotide bindingATP
TgeneIKBKBchr8:42798588chr8:42162705ENST0000052081042221_29129757.0Nucleotide bindingATP
TgeneIKBKBchr8:42798588chr8:42162705ENST0000052083532121_29127755.0Nucleotide bindingATP


Top

Fusion Gene Sequence for HOOK3-IKBKB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37391_37391_1_HOOK3-IKBKB_HOOK3_chr8_42798588_ENST00000307602_IKBKB_chr8_42162705_ENST00000416505_length(transcript)=2636nt_BP=600nt
CGGTCCCGAGTGAAAGGAGAAGGAGGGGCGCTGGGGGTGACGGTGCGGAGCCGCTGCCAGCGCTGGGCGAGAGTCGGCGGCCGGATCCGA
GGAGCAGGCGGGCCTGAGGCCGAGTCAGCTGCGCGGGCCCCCGGATCCCCCGACAGAGCGGCGGCGGTGTCTGGCCAGGCGGTAGGCGCT
GCCTGGCCGCGGCGGGGAAGATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTA
ATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTG
ATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCT
TGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAG
AGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGCCTCTGCGCTTAGATACCTTCATGAAAACA
GAATCATCCATCGGGATCTAAAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGTTAATACACAAAATTATTGACCTAGGATATG
CCAAGGAGCTGGATCAGGGCAGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACA
CAGTGACCGTCGACTACTGGAGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGC
AGTGGCATTCAAAAGTGCGGCAGAAGAGTGAGGTGGACATTGTTGTTAGCGAAGACTTGAATGGAACGGTGAAGTTTTCAAGCTCTTTAC
CCTACCCCAATAATCTTAACAGTGTCCTGGCTGAGCGACTGGAGAAGTGGCTGCAACTGATGCTGATGTGGCACCCCCGACAGAGGGGCA
CGGATCCCACGTATGGGCCCAATGGCTGCTTCAAGGCCCTGGATGACATCTTAAACTTAAAGCTGGTTCATATCTTGAACATGGTCACGG
GCACCATCCACACCTACCCTGTGACAGAGGATGAGAGTCTGCAGAGCTTGAAGGCCAGAATCCAACAGGACACGGGCATCCCAGAGGAGG
ACCAGGAGCTGCTGCAGGAAGCGGGCCTGGCGTTGATCCCCGATAAGCCTGCCACTCAGTGTATTTCAGACGGCAAGTTAAATGAGGGCC
ACACATTGGACATGGATCTTGTTTTTCTCTTTGACAACAGTAAAATCACCTATGAGACTCAGATCTCCCCACGGCCCCAACCTGAAAGTG
TCAGCTGTATCCTTCAAGAGCCCAAGAGGAATCTCGCCTTCTTCCAGCTGAGGAAGGTGTGGGGCCAGGTCTGGCACAGCATCCAGACCC
TGAAGGAAGATTGCAACCGGCTGCAGCAGGGACAGCGAGCCGCCATGATGAATCTCCTCCGAAACAACAGCTGCCTCTCCAAAATGAAGA
ATTCCATGGCTTCCATGTCTCAGCAGCTCAAGGCCAAGTTGGATTTCTTCAAAACCAGCATCCAGATTGACCTGGAGAAGTACAGCGAGC
AAACCGAGTTTGGGATCACATCAGATAAACTGCTGCTGGCCTGGAGGGAAATGGAGCAGGCTGTGGAGCTCTGTGGGCGGGAGAACGAAG
TGAAACTCCTGGTAGAACGGATGATGGCTCTGCAGACCGACATTGTGGACTTACAGAGGAGCCCCATGGGCCGGAAGCAGGGGGGAACGC
TGGACGACCTAGAGGAGCAAGCAAGGGAGCTGTACAGGAGACTAAGGGAAAAACCTCGAGACCAGCGAACTGAGGGTGACAGTCAGGAAA
TGGTACGGCTGCTGCTTCAGGCAATTCAGAGCTTCGAGAAGAAAGTGCGAGTGATCTATACGCAGCTCAGTAAAACTGTGGTTTGCAAGC
AGAAGGCGCTGGAACTGTTGCCCAAGGTGGAAGAGGTGGTGAGCTTAATGAATGAGGATGAGAAGACTGTTGTCCGGCTGCAGGAGAAGC
GGCAGAAGGAGCTCTGGAATCTCCTGAAGATTGCTTGTAGCAAGGTCCGTGGTCCTGTCAGTGGAAGCCCGGATAGCATGAATGCCTCTC
GACTTAGCCAGCCTGGGCAGCTGATGTCTCAGCCCTCCACGGCCTCCAACAGCTTACCTGAGCCAGCCAAGAAGAGTGAAGAACTGGTGG
CTGAAGCACATAACCTCTGCACCCTGCTAGAAAATGCCATACAGGACACTGTGAGGGAACAAGACCAGAGTTTCACGGCCCTAGACTGGA
GCTGGTTACAGACGGAAGAAGAAGAGCACAGCTGCCTGGAGCAGGCCTCATGATGTGGGGGGACTCGACCCCCTGACATGGGGCAGCCCA
TAGCAGGCCTTGTGCAGTGGGGGGACTCGACCCCCTGACATGGGGCTGCCTGGAGCAGGCCGCGTGACGTGGGGCTGCCTGGCCGCGGCT

>37391_37391_1_HOOK3-IKBKB_HOOK3_chr8_42798588_ENST00000307602_IKBKB_chr8_42162705_ENST00000416505_length(amino acids)=766AA_BP=139
MAAAGKMFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGIL
DYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYA
KELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLP
YPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEED
QELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTL
KEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEV
KLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQ
KALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVA

--------------------------------------------------------------
>37391_37391_2_HOOK3-IKBKB_HOOK3_chr8_42798588_ENST00000307602_IKBKB_chr8_42162705_ENST00000519735_length(transcript)=1208nt_BP=600nt
CGGTCCCGAGTGAAAGGAGAAGGAGGGGCGCTGGGGGTGACGGTGCGGAGCCGCTGCCAGCGCTGGGCGAGAGTCGGCGGCCGGATCCGA
GGAGCAGGCGGGCCTGAGGCCGAGTCAGCTGCGCGGGCCCCCGGATCCCCCGACAGAGCGGCGGCGGTGTCTGGCCAGGCGGTAGGCGCT
GCCTGGCCGCGGCGGGGAAGATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTA
ATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTG
ATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCT
TGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAG
AGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGCCTCTGCGCTTAGATACCTTCATGAAAACA
GAATCATCCATCGGGATCTAAAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGTTAATACACAAAATTATTGACCTAGGATATG
CCAAGGAGCTGGATCAGGGCAGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACA
CAGTGACCGTCGACTACTGGAGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGC
AGTGCGTAAGAATGTGGCCGGGTACAGTGGCTCACTCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCAGTTGAGGCCAGC
AGTTCCAGACCAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAACCCTAGCCAGGTGTGGTGGCGGGCGCCTGTAATCCCAGCT
ACTCGGAAGGCTGAGGTGGGAGAATTGCTTAAACCCAGGAGGCAGAGGTCGCATCACTGCAATCCAGCCTGGGCGACAGAGTGAGACTCT

>37391_37391_2_HOOK3-IKBKB_HOOK3_chr8_42798588_ENST00000307602_IKBKB_chr8_42162705_ENST00000519735_length(amino acids)=266AA_BP=139
MAAAGKMFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGIL
DYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYA

--------------------------------------------------------------
>37391_37391_3_HOOK3-IKBKB_HOOK3_chr8_42798588_ENST00000307602_IKBKB_chr8_42162705_ENST00000520810_length(transcript)=3112nt_BP=600nt
CGGTCCCGAGTGAAAGGAGAAGGAGGGGCGCTGGGGGTGACGGTGCGGAGCCGCTGCCAGCGCTGGGCGAGAGTCGGCGGCCGGATCCGA
GGAGCAGGCGGGCCTGAGGCCGAGTCAGCTGCGCGGGCCCCCGGATCCCCCGACAGAGCGGCGGCGGTGTCTGGCCAGGCGGTAGGCGCT
GCCTGGCCGCGGCGGGGAAGATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTA
ATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTG
ATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCT
TGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAG
AGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGCCTCTGCGCTTAGATACCTTCATGAAAACA
GAATCATCCATCGGGATCTAAAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGTTAATACACAAAATTATTGACCTAGGATATG
CCAAGGAGCTGGATCAGGGCAGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACA
CAGTGACCGTCGACTACTGGAGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGC
AGTGGCATTCAAAAGTGCGGCAGAAGAGTGAGGTGGACATTGTTGTTAGCGAAGACTTGAATGGAACGGTGAAGTTTTCAAGCTCTTTAC
CCTACCCCAATAATCTTAACAGTGTCCTGGCTGAGCGACTGGAGAAGTGGCTGCAACTGATGCTGATGTGGCACCCCCGACAGAGGGGCA
CGGATCCCACGTATGGGCCCAATGGCTGCTTCAAGGCCCTGGATGACATCTTAAACTTAAAGCTGGTTCATATCTTGAACATGGTCACGG
GCACCATCCACACCTACCCTGTGACAGAGGATGAGAGTCTGCAGAGCTTGAAGGCCAGAATCCAACAGGACACGGGCATCCCAGAGGAGG
ACCAGGAGCTGCTGCAGGAAGCGGGCCTGGCGTTGATCCCCGATAAGCCTGCCACTCAGTGTATTTCAGACGGCAAGTTAAATGAGGGCC
ACACATTGGACATGGATCTTGTTTTTCTCTTTGACAACAGTAAAATCACCTATGAGACTCAGATCTCCCCACGGCCCCAACCTGAAAGTG
TCAGCTGTATCCTTCAAGAGCCCAAGAGGAATCTCGCCTTCTTCCAGCTGAGGAAGGTGTGGGGCCAGGTCTGGCACAGCATCCAGACCC
TGAAGGAAGATTGCAACCGGCTGCAGCAGGGACAGCGAGCCGCCATGATGAATCTCCTCCGAAACAACAGCTGCCTCTCCAAAATGAAGA
ATTCCATGGCTTCCATGTCTCAGCAGCTCAAGGCCAAGTTGGATTTCTTCAAAACCAGCATCCAGATTGACCTGGAGAAGTACAGCGAGC
AAACCGAGTTTGGGATCACATCAGATAAACTGCTGCTGGCCTGGAGGGAAATGGAGCAGGCTGTGGAGCTCTGTGGGCGGGAGAACGAAG
TGAAACTCCTGGTAGAACGGATGATGGCTCTGCAGACCGACATTGTGGACTTACAGAGGAGCCCCATGGGCCGGAAGCAGGGGGGAACGC
TGGACGACCTAGAGGAGCAAGCAAGGGAGCTGTACAGGAGACTAAGGGAAAAACCTCGAGACCAGCGAACTGAGGGTGACAGTCAGGAAA
TGGTACGGCTGCTGCTTCAGGCAATTCAGAGCTTCGAGAAGAAAGTGCGAGTGATCTATACGCAGCTCAGTAAAACTGTGGTTTGCAAGC
AGAAGGCGCTGGAACTGTTGCCCAAGGTGGAAGAGGTGGTGAGCTTAATGAATGAGGATGAGAAGACTGTTGTCCGGCTGCAGGAGAAGC
GGCAGAAGGAGCTCTGGAATCTCCTGAAGATTGCTTGTAGCAAGGTCCGTGGTCCTGTCAGTGGAAGCCCGGATAGCATGAATGCCTCTC
GACTTAGCCAGCCTGGGCAGCTGATGTCTCAGCCCTCCACGGCCTCCAACAGCTTACCTGAGCCAGCCAAGAAGAGTGAAGAACTGGTGG
CTGAAGCACATAACCTCTGCACCCTGCTAGAAAATGCCATACAGGACACTGTGAGGGAACAAGACCAGAGTTTCACGGCCCTAGACTGGA
GCTGGTTACAGACGGAAGAAGAAGAGCACAGCTGCCTGGAGCAGGCCTCATGATGTGGGGGGACTCGACCCCCTGACATGGGGCAGCCCA
TAGCAGGCCTTGTGCAGTGGGGGGACTCGACCCCCTGACATGGGGCTGCCTGGAGCAGGCCGCGTGACGTGGGGCTGCCTGGCCGCGGCT
CTCACATGGTGGTTCCTGCTGCACTGATGGCCCAGGGGTCTCTGGTATCCAGATGGAGCTCTCGCTTCCTCAGCAGCTGTGACTTTCACC
CAGGACCCAGGACGCAGCCCTCCGTGGGCACTGCCGGCGCCTTGTCTGCACACTGGAGGTCCTCCATTACAGAGGCCCAGCGCACATCGC
TGGCCCCACAAACGTTCAGGGGTACAGCCATGGCAGCTCCTTCCTCTGCCGTGAGAAAAGTGCTTGGAGTACGGTTTGCCACACACGTGA
CTGGACAGTGTCCAATTCAAATCTTTCAGGGCAGAGTCCGAGCAGCGCTTGGTGACAGCCTGTCCTCTCCTGCTCTCCAAAGGCCCTGCT
CCCTGTCCTCTCTCACTTTACAGCTTGTGTTTCTTCTGGATTCAGCTTCTCCTAAACAGACAGTTTAATTATAGTTGCGGCCTGGCCCCA

>37391_37391_3_HOOK3-IKBKB_HOOK3_chr8_42798588_ENST00000307602_IKBKB_chr8_42162705_ENST00000520810_length(amino acids)=766AA_BP=139
MAAAGKMFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGIL
DYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYA
KELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLP
YPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEED
QELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTL
KEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEV
KLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQ
KALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVA

--------------------------------------------------------------
>37391_37391_4_HOOK3-IKBKB_HOOK3_chr8_42798588_ENST00000307602_IKBKB_chr8_42162705_ENST00000520835_length(transcript)=2568nt_BP=600nt
CGGTCCCGAGTGAAAGGAGAAGGAGGGGCGCTGGGGGTGACGGTGCGGAGCCGCTGCCAGCGCTGGGCGAGAGTCGGCGGCCGGATCCGA
GGAGCAGGCGGGCCTGAGGCCGAGTCAGCTGCGCGGGCCCCCGGATCCCCCGACAGAGCGGCGGCGGTGTCTGGCCAGGCGGTAGGCGCT
GCCTGGCCGCGGCGGGGAAGATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTA
ATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTG
ATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCT
TGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAG
AGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGCCTCTGCGCTTAGATACCTTCATGAAAACA
GAATCATCCATCGGGATCTAAAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGTTAATACACAAAATTATTGACCTAGGATATG
CCAAGGAGCTGGATCAGGGCAGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACA
CAGTGACCGTCGACTACTGGAGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGC
AGTGGCATTCAAAAGTGCGGCAGAAGAGTGAGGTGGACATTGTTGTTAGCGAAGACTTGAATGGAACGGTGAAGTTTTCAAGCTCTTTAC
CCTACCCCAATAATCTTAACAGTGTCCTGGCTGAGCGACTGGAGAAGTGGCTGCAACTGATGCTGATGTGGCACCCCCGACAGAGGGGCA
CGGATCCCACGTATGGGCCCAATGGCTGCTTCAAGGCCCTGGATGACATCTTAAACTTAAAGCTGGTTCATATCTTGAACATGGTCACGG
GCACCATCCACACCTACCCTGTGACAGAGGATGAGAGTCTGCAGAGCTTGAAGGCCAGAATCCAACAGGACACGGGCATCCCAGAGGAGG
ACCAGGAGCTGCTGCAGGAAGCGGGCCTGGCGTTGATCCCCGATAAGCCTGCCACTCAGTGTATTTCAGACGGCAAGTTAAATGAGGGCC
ACACATTGGACATGGATCTTGTTTTTCTCTTTGACAACAGTAAAATCACCTATGAGACTCAGATCTCCCCACGGCCCCAACCTGAAAGTG
TCAGCTGTATCCTTCAAGAGCCCAAGAGGAATCTCGCCTTCTTCCAGCTGAGGAAGGTGTGGGGCCAGGTCTGGCACAGCATCCAGACCC
TGAAGGAAGATTGCAACCGGCTGCAGCAGGGACAGCGAGCCGCCATGATGAATCTCCTCCGAAACAACAGCTGCCTCTCCAAAATGAAGA
ATTCCATGGCTTCCATGTCTCAGCAGCTCAAGGCCAAGTTGGATTTCTTCAAAACCAGCATCCAGATTGACCTGGAGAAGTACAGCGAGC
AAACCGAGTTTGGGATCACATCAGATAAACTGCTGCTGGCCTGGAGGGAAATGGAGCAGGCTGTGGAGCTCTGTGGGCGGGAGAACGAAG
TGAAACTCCTGGTAGAACGGATGATGGCTCTGCAGACCGACATTGTGGACTTACAGAGGAGCCCCATGGGCCGGAAGCAGGGGGGAACGC
TGGACGACCTAGAGGAGCAAGCAAGGGAGCTGTACAGGAGACTAAGGGAAAAACCTCGAGACCAGCGAACTGAGGGTGACAGTCAGGAAA
TGGTACGGCTGCTGCTTCAGGCAATTCAGAGCTTCGAGAAGAAAGTGCGAGTGATCTATACGCAGCTCAGTAAAACTGTGGTTTGCAAGC
AGAAGGCGCTGGAACTGTTGCCCAAGGTGGAAGAGGTGGTGAGCTTAATGAATGAGGATGAGAAGACTGTTGTCCGGCTGCAGGAGAAGC
GGCAGAAGGAGCTCTGGAATCTCCTGAAGATTGCTTGTAGCAAGGTCCGTGGTCCTGTCAGTGGAAGCCCGGATAGCATGAATGCCTCTC
GACTTAGCCAGCCTGGGCAGCTGATGTCTCAGCCCTCCACGGCCTCCAACAGCTTACCTGAGCCAGCCAAGAAGAGTGAAGAACTGGTGG
CTGAAGCACATAACCTCTGCACCCTGCTAGAAAATGCCATACAGGACACTGTGAGGGAACAAGACCAGAGTTTCACGGCCCTAGACTGGA
GCTGGTTACAGACGGAAGAAGAAGAGCACAGCTGCCTGGAGCAGGCCTCATGATGTGGGGGGACTCGACCCCCTGACATGGGGCAGCCCA

>37391_37391_4_HOOK3-IKBKB_HOOK3_chr8_42798588_ENST00000307602_IKBKB_chr8_42162705_ENST00000520835_length(amino acids)=766AA_BP=139
MAAAGKMFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGIL
DYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYA
KELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLP
YPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEED
QELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTL
KEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEV
KLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQ
KALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HOOK3-IKBKB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for HOOK3-IKBKB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for HOOK3-IKBKB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource