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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HOOK3-RET (FusionGDB2 ID:37395)

Fusion Gene Summary for HOOK3-RET

check button Fusion gene summary
Fusion gene informationFusion gene name: HOOK3-RET
Fusion gene ID: 37395
HgeneTgene
Gene symbol

HOOK3

RET

Gene ID

84376

5979

Gene namehook microtubule tethering protein 3ret proto-oncogene
SynonymsHK3CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

8p11.21

10q11.21

Type of geneprotein-codingprotein-coding
Descriptionprotein Hook homolog 3h-hook3hHK3hook homolog 3proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2020031320200322
UniProtAcc.

RTL1

Ensembl transtripts involved in fusion geneENST00000307602, ENST00000524839, 
ENST00000340058, ENST00000355710, 
Fusion gene scores* DoF score16 X 13 X 9=187232 X 31 X 11=10912
# samples 1948
** MAII scorelog2(19/1872*10)=-3.30050911125246
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10912*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HOOK3 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHOOK3(42823358)-RET(43612030), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across HOOK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4papilary thyroid carcinomaDQ104207HOOK3chr8

42823358

RETchr10

43612030
ChimerKB3..HOOK3chr8

42823357

+RETchr10

43612031

+
ChimerKB3..HOOK3chr8

42823358

+RETchr10

43612030

+
ChiTaRS5.0N/ADQ104207HOOK3chr8

42823358

+RETchr10

43612030

+


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Fusion Gene ORF analysis for HOOK3-RET

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000307602ENST00000340058HOOK3chr8

42823358

RETchr10

43612030

In-frameENST00000307602ENST00000340058HOOK3chr8

42823357

+RETchr10

43612031

+
In-frameENST00000307602ENST00000340058HOOK3chr8

42823358

+RETchr10

43612030

+
In-frameENST00000307602ENST00000355710HOOK3chr8

42823358

RETchr10

43612030

In-frameENST00000307602ENST00000355710HOOK3chr8

42823357

+RETchr10

43612031

+
In-frameENST00000307602ENST00000355710HOOK3chr8

42823358

+RETchr10

43612030

+
intron-3CDSENST00000524839ENST00000340058HOOK3chr8

42823358

RETchr10

43612030

intron-3CDSENST00000524839ENST00000340058HOOK3chr8

42823357

+RETchr10

43612031

+
intron-3CDSENST00000524839ENST00000340058HOOK3chr8

42823358

+RETchr10

43612030

+
intron-3CDSENST00000524839ENST00000355710HOOK3chr8

42823358

RETchr10

43612030

intron-3CDSENST00000524839ENST00000355710HOOK3chr8

42823357

+RETchr10

43612031

+
intron-3CDSENST00000524839ENST00000355710HOOK3chr8

42823358

+RETchr10

43612030

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000307602HOOK3chr842823357+ENST00000355710RETchr1043612031+461313221822530782
ENST00000307602HOOK3chr842823357+ENST00000340058RETchr1043612031+315513221822404740
ENST00000307602HOOK3chr842823358+ENST00000355710RETchr1043612030+461313221822530782
ENST00000307602HOOK3chr842823358+ENST00000340058RETchr1043612030+315513221822404740
ENST00000307602HOOK3chr842823358ENST00000355710RETchr1043612030461313221822530782
ENST00000307602HOOK3chr842823358ENST00000340058RETchr1043612030315513221822404740

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000307602ENST00000355710HOOK3chr842823358RETchr10436120300.000751780.9992482
ENST00000307602ENST00000340058HOOK3chr842823358RETchr10436120300.0044130480.995587

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Fusion Genomic Features for HOOK3-RET


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HOOK3chr842823357+RETchr1043612031+8.92E-060.99999106
HOOK3chr842823357+RETchr1043612031+8.92E-060.99999106

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HOOK3-RET


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:42823358/chr10:43612030)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RET

RTL1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.1358

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHOOK3chr8:42823358chr10:43612030ENST00000307602+112210_126374719.0DomainCalponin-homology (CH)
TgeneRETchr8:42823358chr10:43612030ENST000003400581019724_10167121073.0DomainProtein kinase
TgeneRETchr8:42823358chr10:43612030ENST000003557101020724_10167121115.0DomainProtein kinase
TgeneRETchr8:42823358chr10:43612030ENST000003400581019730_7387121073.0Nucleotide bindingATP
TgeneRETchr8:42823358chr10:43612030ENST000003557101020730_7387121115.0Nucleotide bindingATP
TgeneRETchr8:42823358chr10:43612030ENST000003400581019805_8077121073.0RegionNote=Inhibitors binding
TgeneRETchr8:42823358chr10:43612030ENST000003557101020805_8077121115.0RegionNote=Inhibitors binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHOOK3chr8:42823358chr10:43612030ENST00000307602+1122167_433374719.0Coiled coilOntology_term=ECO:0000255
HgeneHOOK3chr8:42823358chr10:43612030ENST00000307602+1122462_667374719.0Coiled coilOntology_term=ECO:0000255
HgeneHOOK3chr8:42823358chr10:43612030ENST00000307602+1122553_718374719.0RegionNote=Required for association with Golgi
TgeneRETchr8:42823358chr10:43612030ENST000003400581019168_2727121073.0DomainCadherin
TgeneRETchr8:42823358chr10:43612030ENST000003557101020168_2727121115.0DomainCadherin
TgeneRETchr8:42823358chr10:43612030ENST00000340058101929_6357121073.0Topological domainExtracellular
TgeneRETchr8:42823358chr10:43612030ENST000003400581019658_11147121073.0Topological domainCytoplasmic
TgeneRETchr8:42823358chr10:43612030ENST00000355710102029_6357121115.0Topological domainExtracellular
TgeneRETchr8:42823358chr10:43612030ENST000003557101020658_11147121115.0Topological domainCytoplasmic
TgeneRETchr8:42823358chr10:43612030ENST000003400581019636_6577121073.0TransmembraneHelical
TgeneRETchr8:42823358chr10:43612030ENST000003557101020636_6577121115.0TransmembraneHelical


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Fusion Gene Sequence for HOOK3-RET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37395_37395_1_HOOK3-RET_HOOK3_chr8_42823357_ENST00000307602_RET_chr10_43612031_ENST00000340058_length(transcript)=3155nt_BP=1322nt
CGGTCCCGAGTGAAAGGAGAAGGAGGGGCGCTGGGGGTGACGGTGCGGAGCCGCTGCCAGCGCTGGGCGAGAGTCGGCGGCCGGATCCGA
GGAGCAGGCGGGCCTGAGGCCGAGTCAGCTGCGCGGGCCCCCGGATCCCCCGACAGAGCGGCGGCGGTGTCTGGCCAGGCGGTAGGCGCT
GCCTGGCCGCGGCGGGGAAGATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTA
ATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTG
ATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCT
TGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAG
AGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGAGTACATCCAAGCCATTATGATGATGGAGG
AATCTGTTCAACATGTTGTCATGACAGCCATTCAAGAGCTGATGAGTAAAGAATCTCCTGTCTCTGCTGGAAATGATGCCTATGTTGACC
TTGATCGTCAGCTGAAGAAAACTACAGAGGAACTAAATGAAGCTTTGTCAGCAAAGGAAGAAATTGCTCAAAGATGCCATGAACTGGATA
TGCAGGTTGCAGCATTGCAGGAAGAGAAAAGTAGTTTGTTGGCAGAGAATCAGGTATTAATGGAAAGACTCAATCAATCTGATTCTATAG
AAGACCCTAACAGTCCAGCAGGAAGAAGGCATTTGCAGCTCCAGACTCAATTAGAACAGCTCCAAGAAGAAACATTCAGACTAGAAGCAG
CCAAAGATGATTATCGAATACGTTGTGAAGAGTTAGAAAAGGAGATCTCTGAACTTCGGCAACAGAATGATGAACTGACCACTTTGGCAG
ATGAAGCTCAGTCTCTGAAAGATGAGATCGACGTGCTGAGACATTCTTCTGATAAAGTATCTAAACTAGAAGGTCAAGTAGAATCTTATA
AAAAGAAGCTAGAAGACCTTGGTGATTTAAGGCGGCAGGTTAAACTCTTAGAAGAGAAGAATACCATGTATATGCAGAATACTGTCAGTC
TAGAGGAAGAGTTAAGAAAGGCCAACGCAGCGCGAAGTCAACTTGAAACCTACAAGAGACAGGAGGATCCAAAGTGGGAATTCCCTCGGA
AGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGT
ACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGG
TCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCC
TGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGG
ATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTC
ATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAG
AGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAA
GTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCA
ACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGC
CGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCA
CTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCC
TCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCC
TTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTT
GCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTA
GGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGT
CATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTG
CACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGC
CAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCAC
TGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAA
GAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTGATTAAATACTAGA

>37395_37395_1_HOOK3-RET_HOOK3_chr8_42823357_ENST00000307602_RET_chr10_43612031_ENST00000340058_length(amino acids)=740AA_BP=380
MAAAGKMFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGIL
DYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDL
DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAA
KDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSL
EEELRKANAARSQLETYKRQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV
NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFN
LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL

--------------------------------------------------------------
>37395_37395_2_HOOK3-RET_HOOK3_chr8_42823357_ENST00000307602_RET_chr10_43612031_ENST00000355710_length(transcript)=4613nt_BP=1322nt
CGGTCCCGAGTGAAAGGAGAAGGAGGGGCGCTGGGGGTGACGGTGCGGAGCCGCTGCCAGCGCTGGGCGAGAGTCGGCGGCCGGATCCGA
GGAGCAGGCGGGCCTGAGGCCGAGTCAGCTGCGCGGGCCCCCGGATCCCCCGACAGAGCGGCGGCGGTGTCTGGCCAGGCGGTAGGCGCT
GCCTGGCCGCGGCGGGGAAGATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTA
ATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTG
ATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCT
TGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAG
AGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGAGTACATCCAAGCCATTATGATGATGGAGG
AATCTGTTCAACATGTTGTCATGACAGCCATTCAAGAGCTGATGAGTAAAGAATCTCCTGTCTCTGCTGGAAATGATGCCTATGTTGACC
TTGATCGTCAGCTGAAGAAAACTACAGAGGAACTAAATGAAGCTTTGTCAGCAAAGGAAGAAATTGCTCAAAGATGCCATGAACTGGATA
TGCAGGTTGCAGCATTGCAGGAAGAGAAAAGTAGTTTGTTGGCAGAGAATCAGGTATTAATGGAAAGACTCAATCAATCTGATTCTATAG
AAGACCCTAACAGTCCAGCAGGAAGAAGGCATTTGCAGCTCCAGACTCAATTAGAACAGCTCCAAGAAGAAACATTCAGACTAGAAGCAG
CCAAAGATGATTATCGAATACGTTGTGAAGAGTTAGAAAAGGAGATCTCTGAACTTCGGCAACAGAATGATGAACTGACCACTTTGGCAG
ATGAAGCTCAGTCTCTGAAAGATGAGATCGACGTGCTGAGACATTCTTCTGATAAAGTATCTAAACTAGAAGGTCAAGTAGAATCTTATA
AAAAGAAGCTAGAAGACCTTGGTGATTTAAGGCGGCAGGTTAAACTCTTAGAAGAGAAGAATACCATGTATATGCAGAATACTGTCAGTC
TAGAGGAAGAGTTAAGAAAGGCCAACGCAGCGCGAAGTCAACTTGAAACCTACAAGAGACAGGAGGATCCAAAGTGGGAATTCCCTCGGA
AGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGT
ACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGG
TCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCC
TGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGG
ATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTC
ATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAG
AGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAA
GTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCA
ACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGC
CGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCA
CTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCC
TCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATG
GCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGT
TTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGT
GAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCT
GATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGC
CCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTA
TGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAG
TAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGG
CTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTT
AGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGT
GGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCC
TGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCA
GCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATT
TGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGA
TTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTT
AATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGA
TGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGA
AAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTAT
ATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCA
CACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTC
TTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTT
CTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCT
GACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTT
ATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTAT
TAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGAAAATCAGTTGTGT

>37395_37395_2_HOOK3-RET_HOOK3_chr8_42823357_ENST00000307602_RET_chr10_43612031_ENST00000355710_length(amino acids)=782AA_BP=380
MAAAGKMFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGIL
DYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDL
DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAA
KDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSL
EEELRKANAARSQLETYKRQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV
NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFN
LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL

--------------------------------------------------------------
>37395_37395_3_HOOK3-RET_HOOK3_chr8_42823358_ENST00000307602_RET_chr10_43612030_ENST00000340058_length(transcript)=3155nt_BP=1322nt
CGGTCCCGAGTGAAAGGAGAAGGAGGGGCGCTGGGGGTGACGGTGCGGAGCCGCTGCCAGCGCTGGGCGAGAGTCGGCGGCCGGATCCGA
GGAGCAGGCGGGCCTGAGGCCGAGTCAGCTGCGCGGGCCCCCGGATCCCCCGACAGAGCGGCGGCGGTGTCTGGCCAGGCGGTAGGCGCT
GCCTGGCCGCGGCGGGGAAGATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTA
ATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTG
ATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCT
TGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAG
AGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGAGTACATCCAAGCCATTATGATGATGGAGG
AATCTGTTCAACATGTTGTCATGACAGCCATTCAAGAGCTGATGAGTAAAGAATCTCCTGTCTCTGCTGGAAATGATGCCTATGTTGACC
TTGATCGTCAGCTGAAGAAAACTACAGAGGAACTAAATGAAGCTTTGTCAGCAAAGGAAGAAATTGCTCAAAGATGCCATGAACTGGATA
TGCAGGTTGCAGCATTGCAGGAAGAGAAAAGTAGTTTGTTGGCAGAGAATCAGGTATTAATGGAAAGACTCAATCAATCTGATTCTATAG
AAGACCCTAACAGTCCAGCAGGAAGAAGGCATTTGCAGCTCCAGACTCAATTAGAACAGCTCCAAGAAGAAACATTCAGACTAGAAGCAG
CCAAAGATGATTATCGAATACGTTGTGAAGAGTTAGAAAAGGAGATCTCTGAACTTCGGCAACAGAATGATGAACTGACCACTTTGGCAG
ATGAAGCTCAGTCTCTGAAAGATGAGATCGACGTGCTGAGACATTCTTCTGATAAAGTATCTAAACTAGAAGGTCAAGTAGAATCTTATA
AAAAGAAGCTAGAAGACCTTGGTGATTTAAGGCGGCAGGTTAAACTCTTAGAAGAGAAGAATACCATGTATATGCAGAATACTGTCAGTC
TAGAGGAAGAGTTAAGAAAGGCCAACGCAGCGCGAAGTCAACTTGAAACCTACAAGAGACAGGAGGATCCAAAGTGGGAATTCCCTCGGA
AGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGT
ACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGG
TCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCC
TGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGG
ATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTC
ATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAG
AGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAA
GTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCA
ACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGC
CGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCA
CTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCC
TCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCC
TTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTT
GCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTA
GGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGT
CATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTG
CACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGC
CAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCAC
TGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAA
GAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTGATTAAATACTAGA

>37395_37395_3_HOOK3-RET_HOOK3_chr8_42823358_ENST00000307602_RET_chr10_43612030_ENST00000340058_length(amino acids)=740AA_BP=380
MAAAGKMFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGIL
DYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDL
DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAA
KDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSL
EEELRKANAARSQLETYKRQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV
NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFN
LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL

--------------------------------------------------------------
>37395_37395_4_HOOK3-RET_HOOK3_chr8_42823358_ENST00000307602_RET_chr10_43612030_ENST00000355710_length(transcript)=4613nt_BP=1322nt
CGGTCCCGAGTGAAAGGAGAAGGAGGGGCGCTGGGGGTGACGGTGCGGAGCCGCTGCCAGCGCTGGGCGAGAGTCGGCGGCCGGATCCGA
GGAGCAGGCGGGCCTGAGGCCGAGTCAGCTGCGCGGGCCCCCGGATCCCCCGACAGAGCGGCGGCGGTGTCTGGCCAGGCGGTAGGCGCT
GCCTGGCCGCGGCGGGGAAGATGTTCAGCGTAGAGTCGCTGGAGCGGGCGGAGCTGTGCGAGAGCCTCCTCACTTGGATCCAGACATTTA
ATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTGCATATTTTG
ATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAAAAGGAATCT
TGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTGATGCAGCAG
AGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGAGTACATCCAAGCCATTATGATGATGGAGG
AATCTGTTCAACATGTTGTCATGACAGCCATTCAAGAGCTGATGAGTAAAGAATCTCCTGTCTCTGCTGGAAATGATGCCTATGTTGACC
TTGATCGTCAGCTGAAGAAAACTACAGAGGAACTAAATGAAGCTTTGTCAGCAAAGGAAGAAATTGCTCAAAGATGCCATGAACTGGATA
TGCAGGTTGCAGCATTGCAGGAAGAGAAAAGTAGTTTGTTGGCAGAGAATCAGGTATTAATGGAAAGACTCAATCAATCTGATTCTATAG
AAGACCCTAACAGTCCAGCAGGAAGAAGGCATTTGCAGCTCCAGACTCAATTAGAACAGCTCCAAGAAGAAACATTCAGACTAGAAGCAG
CCAAAGATGATTATCGAATACGTTGTGAAGAGTTAGAAAAGGAGATCTCTGAACTTCGGCAACAGAATGATGAACTGACCACTTTGGCAG
ATGAAGCTCAGTCTCTGAAAGATGAGATCGACGTGCTGAGACATTCTTCTGATAAAGTATCTAAACTAGAAGGTCAAGTAGAATCTTATA
AAAAGAAGCTAGAAGACCTTGGTGATTTAAGGCGGCAGGTTAAACTCTTAGAAGAGAAGAATACCATGTATATGCAGAATACTGTCAGTC
TAGAGGAAGAGTTAAGAAAGGCCAACGCAGCGCGAAGTCAACTTGAAACCTACAAGAGACAGGAGGATCCAAAGTGGGAATTCCCTCGGA
AGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGT
ACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGG
TCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCC
TGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGG
ATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTC
ATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAG
AGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAA
GTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCA
ACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGC
CGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCA
CTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCC
TCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATG
GCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGT
TTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGT
GAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCT
GATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGC
CCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTA
TGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAG
TAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGG
CTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTT
AGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGT
GGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCC
TGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCA
GCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATT
TGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGA
TTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTT
AATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGA
TGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGA
AAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTAT
ATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCA
CACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTC
TTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTT
CTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCT
GACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTT
ATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTAT
TAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGAAAATCAGTTGTGT

>37395_37395_4_HOOK3-RET_HOOK3_chr8_42823358_ENST00000307602_RET_chr10_43612030_ENST00000355710_length(amino acids)=782AA_BP=380
MAAAGKMFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGIL
DYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDL
DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAA
KDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSL
EEELRKANAARSQLETYKRQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV
NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFN
LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HOOK3-RET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HOOK3-RET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HOOK3-RET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource