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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HOXA3-KIAA0895 (FusionGDB2 ID:37421)

Fusion Gene Summary for HOXA3-KIAA0895

check button Fusion gene summary
Fusion gene informationFusion gene name: HOXA3-KIAA0895
Fusion gene ID: 37421
HgeneTgene
Gene symbol

HOXA3

KIAA0895

Gene ID

3200

23366

Gene namehomeobox A3KIAA0895
SynonymsHOX1|HOX1E-
Cytomap

7p15.2

7p14.2

Type of geneprotein-codingprotein-coding
Descriptionhomeobox protein Hox-A3Hox-1.5-like proteinhomeo box 1Ehomeo box A3homeobox protein Hox-1Euncharacterized protein KIAA0895
Modification date2020031320200313
UniProtAcc

O43365

Q68EN5

Ensembl transtripts involved in fusion geneENST00000317201, ENST00000521401, 
ENST00000396352, 		ENST00000297063, 
ENST00000317020, ENST00000338533, 
ENST00000440378, ENST00000436884, 
ENST00000415803, ENST00000453212, 
ENST00000480192, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 4 X 3=36
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HOXA3 [Title/Abstract] AND KIAA0895 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHOXA3(27150345)-KIAA0895(36429636), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HOXA3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KIAA0895 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-A5TY-01AHOXA3chr7

27150345

-KIAA0895chr7

36429636

-
ChimerDB4LGGTCGA-DU-A5TY-01AHOXA3chr7

27162178

-KIAA0895chr7

36397199

-
ChimerDB4LGGTCGA-DU-A5TYHOXA3chr7

27150345

-KIAA0895chr7

36429636

-


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Fusion Gene ORF analysis for HOXA3-KIAA0895

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000317201ENST00000297063HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-3CDSENST00000317201ENST00000317020HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-3CDSENST00000317201ENST00000338533HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-3CDSENST00000317201ENST00000440378HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-3CDSENST00000521401ENST00000297063HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-3CDSENST00000521401ENST00000317020HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-3CDSENST00000521401ENST00000338533HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-3CDSENST00000521401ENST00000440378HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-5UTRENST00000317201ENST00000436884HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-5UTRENST00000521401ENST00000436884HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-intronENST00000317201ENST00000415803HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-intronENST00000317201ENST00000453212HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-intronENST00000317201ENST00000480192HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-intronENST00000521401ENST00000415803HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-intronENST00000521401ENST00000453212HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
5UTR-intronENST00000521401ENST00000480192HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
intron-3CDSENST00000317201ENST00000297063HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-3CDSENST00000396352ENST00000297063HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-3CDSENST00000396352ENST00000297063HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
intron-3CDSENST00000396352ENST00000317020HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
intron-3CDSENST00000396352ENST00000338533HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
intron-3CDSENST00000396352ENST00000440378HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
intron-3CDSENST00000521401ENST00000297063HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-5UTRENST00000396352ENST00000436884HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
intron-intronENST00000317201ENST00000317020HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000317201ENST00000338533HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000317201ENST00000415803HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000317201ENST00000436884HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000317201ENST00000440378HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000317201ENST00000453212HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000317201ENST00000480192HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000396352ENST00000317020HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000396352ENST00000338533HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000396352ENST00000415803HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000396352ENST00000415803HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
intron-intronENST00000396352ENST00000436884HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000396352ENST00000440378HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000396352ENST00000453212HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000396352ENST00000453212HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
intron-intronENST00000396352ENST00000480192HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000396352ENST00000480192HOXA3chr7

27162178

-KIAA0895chr7

36397199

-
intron-intronENST00000521401ENST00000317020HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000521401ENST00000338533HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000521401ENST00000415803HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000521401ENST00000436884HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000521401ENST00000440378HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000521401ENST00000453212HOXA3chr7

27150345

-KIAA0895chr7

36429636

-
intron-intronENST00000521401ENST00000480192HOXA3chr7

27150345

-KIAA0895chr7

36429636

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HOXA3-KIAA0895


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HOXA3-KIAA0895


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27150345/:36429636)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HOXA3

O43365

KIAA0895

Q68EN5

FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HOXA3-KIAA0895


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HOXA3-KIAA0895


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HOXA3-KIAA0895


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HOXA3-KIAA0895


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource