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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HOXB3-HOXB3 (FusionGDB2 ID:37428)

Fusion Gene Summary for HOXB3-HOXB3

Fusion gene summary

Fusion gene information	Fusion gene name: HOXB3-HOXB3
	Fusion gene ID: 37428
		Hgene	Tgene
	Gene symbol	HOXB3	HOXB3
	Gene ID	3213	3213
	Gene name	homeobox B3	homeobox B3
	Synonyms	HOX2\|HOX2G\|Hox-2.7	HOX2\|HOX2G\|Hox-2.7
	Cytomap	17q21.32	17q21.32
	Type of gene	protein-coding	protein-coding
	Description	homeobox protein Hox-B3homeo box 2Ghomeobox protein Hox-2.7homeobox protein Hox-2G	homeobox protein Hox-B3homeo box 2Ghomeobox protein Hox-2.7homeobox protein Hox-2G
	Modification date	20200313	20200313
	UniProtAcc	P14651	P14651
	Ensembl transtripts involved in fusion gene	ENST00000311626, ENST00000460160, ENST00000465120, ENST00000470495, ENST00000472863, ENST00000476342, ENST00000485909, ENST00000489475, ENST00000490677, ENST00000498678, ENST00000552000,	ENST00000311626, ENST00000460160, ENST00000465120, ENST00000470495, ENST00000472863, ENST00000476342, ENST00000485909, ENST00000489475, ENST00000490677, ENST00000498678, ENST00000552000,
Fusion gene scores	* DoF score	9 X 6 X 6=324	4 X 5 X 4=80
	# samples	10	7
	** MAII score	log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/80*10)=-0.192645077942396 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HOXB3 [Title/Abstract] AND HOXB3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HOXB3(46653878)-HOXB3(46653125), # samples:1 HOXB3(46657952)-HOXB3(46657885), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HOXB3	GO:0045944	positive regulation of transcription by RNA polymerase II	9556594
Tgene	HOXB3	GO:0045944	positive regulation of transcription by RNA polymerase II	9556594

Fusion gene breakpoints across HOXB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HOXB3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AA687698	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
ChiTaRS5.0	N/A	AA904228	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+

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Fusion Gene ORF analysis for HOXB3-HOXB3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000311626	ENST00000311626	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000311626	ENST00000311626	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000311626	ENST00000460160	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000311626	ENST00000460160	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000311626	ENST00000465120	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000311626	ENST00000465120	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000311626	ENST00000470495	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000311626	ENST00000470495	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000311626	ENST00000472863	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000311626	ENST00000472863	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000311626	ENST00000476342	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000311626	ENST00000476342	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000311626	ENST00000485909	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000311626	ENST00000485909	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000311626	ENST00000489475	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000311626	ENST00000489475	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000311626	ENST00000490677	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000311626	ENST00000490677	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000311626	ENST00000498678	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000311626	ENST00000498678	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000311626	ENST00000552000	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000311626	ENST00000552000	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000460160	ENST00000311626	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000460160	ENST00000311626	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000460160	ENST00000460160	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000460160	ENST00000460160	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000460160	ENST00000465120	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000460160	ENST00000465120	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000460160	ENST00000470495	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000460160	ENST00000470495	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000460160	ENST00000472863	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000460160	ENST00000472863	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000460160	ENST00000476342	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000460160	ENST00000476342	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000460160	ENST00000485909	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000460160	ENST00000485909	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000460160	ENST00000489475	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000460160	ENST00000489475	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000460160	ENST00000490677	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000460160	ENST00000490677	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000460160	ENST00000498678	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000460160	ENST00000498678	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000460160	ENST00000552000	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000460160	ENST00000552000	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000465120	ENST00000311626	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000465120	ENST00000311626	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000465120	ENST00000460160	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000465120	ENST00000460160	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000465120	ENST00000465120	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000465120	ENST00000465120	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000465120	ENST00000470495	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000465120	ENST00000470495	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000465120	ENST00000472863	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000465120	ENST00000472863	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000465120	ENST00000476342	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000465120	ENST00000476342	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000465120	ENST00000485909	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000465120	ENST00000485909	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000465120	ENST00000489475	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000465120	ENST00000489475	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000465120	ENST00000490677	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000465120	ENST00000490677	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000465120	ENST00000498678	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000465120	ENST00000498678	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000465120	ENST00000552000	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000465120	ENST00000552000	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000470495	ENST00000311626	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000470495	ENST00000311626	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000470495	ENST00000460160	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000470495	ENST00000460160	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000470495	ENST00000465120	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000470495	ENST00000465120	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000470495	ENST00000470495	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000470495	ENST00000470495	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000470495	ENST00000472863	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000470495	ENST00000472863	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000470495	ENST00000476342	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000470495	ENST00000476342	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000470495	ENST00000485909	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000470495	ENST00000485909	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000470495	ENST00000489475	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000470495	ENST00000489475	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000470495	ENST00000490677	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000470495	ENST00000490677	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000470495	ENST00000498678	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000470495	ENST00000498678	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000470495	ENST00000552000	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000470495	ENST00000552000	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000472863	ENST00000311626	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000472863	ENST00000311626	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000472863	ENST00000460160	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000472863	ENST00000460160	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000472863	ENST00000465120	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000472863	ENST00000465120	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000472863	ENST00000470495	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000472863	ENST00000470495	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000472863	ENST00000472863	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000472863	ENST00000472863	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000472863	ENST00000476342	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000472863	ENST00000476342	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000472863	ENST00000485909	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000472863	ENST00000485909	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000472863	ENST00000489475	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000472863	ENST00000489475	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000472863	ENST00000490677	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000472863	ENST00000490677	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000472863	ENST00000498678	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000472863	ENST00000498678	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000472863	ENST00000552000	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000472863	ENST00000552000	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000476342	ENST00000311626	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000476342	ENST00000311626	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000476342	ENST00000460160	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000476342	ENST00000460160	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000476342	ENST00000465120	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000476342	ENST00000465120	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000476342	ENST00000470495	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000476342	ENST00000470495	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000476342	ENST00000472863	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000476342	ENST00000472863	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000476342	ENST00000476342	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000476342	ENST00000476342	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000476342	ENST00000485909	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000476342	ENST00000485909	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000476342	ENST00000489475	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000476342	ENST00000489475	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000476342	ENST00000490677	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000476342	ENST00000490677	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000476342	ENST00000498678	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000476342	ENST00000498678	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000476342	ENST00000552000	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000476342	ENST00000552000	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000485909	ENST00000311626	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000485909	ENST00000311626	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000485909	ENST00000460160	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000485909	ENST00000460160	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000485909	ENST00000465120	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000485909	ENST00000465120	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000485909	ENST00000470495	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000485909	ENST00000470495	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000485909	ENST00000472863	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000485909	ENST00000472863	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000485909	ENST00000476342	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000485909	ENST00000476342	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000485909	ENST00000485909	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000485909	ENST00000485909	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000485909	ENST00000489475	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000485909	ENST00000489475	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000485909	ENST00000490677	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000485909	ENST00000490677	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000485909	ENST00000498678	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000485909	ENST00000498678	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000485909	ENST00000552000	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000485909	ENST00000552000	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000489475	ENST00000311626	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000489475	ENST00000311626	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000489475	ENST00000460160	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000489475	ENST00000460160	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000489475	ENST00000465120	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000489475	ENST00000465120	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000489475	ENST00000470495	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000489475	ENST00000470495	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000489475	ENST00000472863	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000489475	ENST00000472863	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000489475	ENST00000476342	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000489475	ENST00000476342	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000489475	ENST00000485909	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000489475	ENST00000485909	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000489475	ENST00000489475	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000489475	ENST00000489475	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000489475	ENST00000490677	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000489475	ENST00000490677	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000489475	ENST00000498678	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000489475	ENST00000498678	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000489475	ENST00000552000	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000489475	ENST00000552000	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000490677	ENST00000311626	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000490677	ENST00000311626	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000490677	ENST00000460160	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000490677	ENST00000460160	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000490677	ENST00000465120	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000490677	ENST00000465120	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000490677	ENST00000470495	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000490677	ENST00000470495	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000490677	ENST00000472863	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000490677	ENST00000472863	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000490677	ENST00000476342	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000490677	ENST00000476342	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000490677	ENST00000485909	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000490677	ENST00000485909	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000490677	ENST00000489475	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000490677	ENST00000489475	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000490677	ENST00000490677	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000490677	ENST00000490677	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000490677	ENST00000498678	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000490677	ENST00000498678	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000490677	ENST00000552000	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000490677	ENST00000552000	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000498678	ENST00000311626	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000498678	ENST00000311626	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000498678	ENST00000460160	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000498678	ENST00000460160	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000498678	ENST00000465120	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000498678	ENST00000465120	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000498678	ENST00000470495	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000498678	ENST00000470495	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000498678	ENST00000472863	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000498678	ENST00000472863	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000498678	ENST00000476342	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000498678	ENST00000476342	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000498678	ENST00000485909	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000498678	ENST00000485909	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000498678	ENST00000489475	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000498678	ENST00000489475	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000498678	ENST00000490677	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000498678	ENST00000490677	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000498678	ENST00000498678	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000498678	ENST00000498678	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000498678	ENST00000552000	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000498678	ENST00000552000	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000552000	ENST00000311626	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000552000	ENST00000311626	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000552000	ENST00000460160	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000552000	ENST00000460160	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000552000	ENST00000465120	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000552000	ENST00000465120	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000552000	ENST00000470495	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000552000	ENST00000470495	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000552000	ENST00000472863	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000552000	ENST00000472863	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000552000	ENST00000476342	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000552000	ENST00000476342	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000552000	ENST00000485909	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000552000	ENST00000485909	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000552000	ENST00000489475	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000552000	ENST00000489475	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000552000	ENST00000490677	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000552000	ENST00000490677	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000552000	ENST00000498678	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000552000	ENST00000498678	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+
intron-intron	ENST00000552000	ENST00000552000	HOXB3	chr17	46653878	+	HOXB3	chr17	46653125	+
intron-intron	ENST00000552000	ENST00000552000	HOXB3	chr17	46657952	-	HOXB3	chr17	46657885	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for HOXB3-HOXB3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for HOXB3-HOXB3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:46653878/:46653125)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HOXB3 P14651	HOXB3 P14651
FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for HOXB3-HOXB3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for HOXB3-HOXB3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for HOXB3-HOXB3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for HOXB3-HOXB3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source