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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HOXB3-TCF12 (FusionGDB2 ID:37433)

Fusion Gene Summary for HOXB3-TCF12

check button Fusion gene summary
Fusion gene informationFusion gene name: HOXB3-TCF12
Fusion gene ID: 37433
HgeneTgene
Gene symbol

HOXB3

TCF12

Gene ID

3213

6938

Gene namehomeobox B3transcription factor 12
SynonymsHOX2|HOX2G|Hox-2.7CRS3|HEB|HTF4|HsT17266|TCF-12|bHLHb20|p64
Cytomap

17q21.32

15q21.3

Type of geneprotein-codingprotein-coding
Descriptionhomeobox protein Hox-B3homeo box 2Ghomeobox protein Hox-2.7homeobox protein Hox-2Gtranscription factor 12DNA-binding protein HTF4E-box-binding proteinclass B basic helix-loop-helix protein 20helix-loop-helix transcription factor 4transcription factor HTF-4
Modification date2020031320200313
UniProtAcc

P14651

.
Ensembl transtripts involved in fusion geneENST00000465120, ENST00000490677, 
ENST00000311626, ENST00000460160, 
ENST00000485909, ENST00000489475, 
ENST00000498678, ENST00000470495, 
ENST00000472863, ENST00000476342, 
ENST00000552000, 		ENST00000343827, 
ENST00000537840, ENST00000543579, 
ENST00000560764, ENST00000559703, 
ENST00000559710, ENST00000267811, 
ENST00000333725, ENST00000438423, 
ENST00000452095, ENST00000557843, 
Fusion gene scores* DoF score9 X 6 X 6=32421 X 22 X 8=3696
# samples 1026
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/3696*10)=-3.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HOXB3 [Title/Abstract] AND TCF12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHOXB3(46651199)-TCF12(57523350), # samples:2
Anticipated loss of major functional domain due to fusion event.HOXB3-TCF12 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
HOXB3-TCF12 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
HOXB3-TCF12 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHOXB3

GO:0045944

positive regulation of transcription by RNA polymerase II

9556594

TgeneTCF12

GO:0045944

positive regulation of transcription by RNA polymerase II

11802795


check buttonFusion gene breakpoints across HOXB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TCF12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-BK-A139-02AHOXB3chr17

46651199

-TCF12chr15

57523350

+


Top

Fusion Gene ORF analysis for HOXB3-TCF12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000465120ENST00000343827HOXB3chr17

46651199

-TCF12chr15

57523350

+
5CDS-3UTRENST00000465120ENST00000537840HOXB3chr17

46651199

-TCF12chr15

57523350

+
5CDS-3UTRENST00000465120ENST00000543579HOXB3chr17

46651199

-TCF12chr15

57523350

+
5CDS-3UTRENST00000465120ENST00000560764HOXB3chr17

46651199

-TCF12chr15

57523350

+
5CDS-3UTRENST00000490677ENST00000343827HOXB3chr17

46651199

-TCF12chr15

57523350

+
5CDS-3UTRENST00000490677ENST00000537840HOXB3chr17

46651199

-TCF12chr15

57523350

+
5CDS-3UTRENST00000490677ENST00000543579HOXB3chr17

46651199

-TCF12chr15

57523350

+
5CDS-3UTRENST00000490677ENST00000560764HOXB3chr17

46651199

-TCF12chr15

57523350

+
5CDS-intronENST00000465120ENST00000559703HOXB3chr17

46651199

-TCF12chr15

57523350

+
5CDS-intronENST00000465120ENST00000559710HOXB3chr17

46651199

-TCF12chr15

57523350

+
5CDS-intronENST00000490677ENST00000559703HOXB3chr17

46651199

-TCF12chr15

57523350

+
5CDS-intronENST00000490677ENST00000559710HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000311626ENST00000267811HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000311626ENST00000333725HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000311626ENST00000438423HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000311626ENST00000452095HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000311626ENST00000557843HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000460160ENST00000267811HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000460160ENST00000333725HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000460160ENST00000438423HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000460160ENST00000452095HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000460160ENST00000557843HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000485909ENST00000267811HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000485909ENST00000333725HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000485909ENST00000438423HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000485909ENST00000452095HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000485909ENST00000557843HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000489475ENST00000267811HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000489475ENST00000333725HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000489475ENST00000438423HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000489475ENST00000452095HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000489475ENST00000557843HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000498678ENST00000267811HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000498678ENST00000333725HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000498678ENST00000438423HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000498678ENST00000452095HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3CDSENST00000498678ENST00000557843HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000311626ENST00000343827HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000311626ENST00000537840HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000311626ENST00000543579HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000311626ENST00000560764HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000460160ENST00000343827HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000460160ENST00000537840HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000460160ENST00000543579HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000460160ENST00000560764HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000485909ENST00000343827HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000485909ENST00000537840HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000485909ENST00000543579HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000485909ENST00000560764HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000489475ENST00000343827HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000489475ENST00000537840HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000489475ENST00000543579HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000489475ENST00000560764HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000498678ENST00000343827HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000498678ENST00000537840HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000498678ENST00000543579HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-3UTRENST00000498678ENST00000560764HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-intronENST00000311626ENST00000559703HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-intronENST00000311626ENST00000559710HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-intronENST00000460160ENST00000559703HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-intronENST00000460160ENST00000559710HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-intronENST00000485909ENST00000559703HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-intronENST00000485909ENST00000559710HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-intronENST00000489475ENST00000559703HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-intronENST00000489475ENST00000559710HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-intronENST00000498678ENST00000559703HOXB3chr17

46651199

-TCF12chr15

57523350

+
5UTR-intronENST00000498678ENST00000559710HOXB3chr17

46651199

-TCF12chr15

57523350

+
Frame-shiftENST00000465120ENST00000267811HOXB3chr17

46651199

-TCF12chr15

57523350

+
Frame-shiftENST00000465120ENST00000333725HOXB3chr17

46651199

-TCF12chr15

57523350

+
Frame-shiftENST00000465120ENST00000438423HOXB3chr17

46651199

-TCF12chr15

57523350

+
Frame-shiftENST00000465120ENST00000452095HOXB3chr17

46651199

-TCF12chr15

57523350

+
Frame-shiftENST00000465120ENST00000557843HOXB3chr17

46651199

-TCF12chr15

57523350

+
In-frameENST00000490677ENST00000267811HOXB3chr17

46651199

-TCF12chr15

57523350

+
In-frameENST00000490677ENST00000333725HOXB3chr17

46651199

-TCF12chr15

57523350

+
In-frameENST00000490677ENST00000438423HOXB3chr17

46651199

-TCF12chr15

57523350

+
In-frameENST00000490677ENST00000452095HOXB3chr17

46651199

-TCF12chr15

57523350

+
In-frameENST00000490677ENST00000557843HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000470495ENST00000267811HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000470495ENST00000333725HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000470495ENST00000438423HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000470495ENST00000452095HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000470495ENST00000557843HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000472863ENST00000267811HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000472863ENST00000333725HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000472863ENST00000438423HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000472863ENST00000452095HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000472863ENST00000557843HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000476342ENST00000267811HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000476342ENST00000333725HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000476342ENST00000438423HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000476342ENST00000452095HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000476342ENST00000557843HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000552000ENST00000267811HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000552000ENST00000333725HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000552000ENST00000438423HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000552000ENST00000452095HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3CDSENST00000552000ENST00000557843HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000470495ENST00000343827HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000470495ENST00000537840HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000470495ENST00000543579HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000470495ENST00000560764HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000472863ENST00000343827HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000472863ENST00000537840HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000472863ENST00000543579HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000472863ENST00000560764HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000476342ENST00000343827HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000476342ENST00000537840HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000476342ENST00000543579HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000476342ENST00000560764HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000552000ENST00000343827HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000552000ENST00000537840HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000552000ENST00000543579HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-3UTRENST00000552000ENST00000560764HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-intronENST00000470495ENST00000559703HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-intronENST00000470495ENST00000559710HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-intronENST00000472863ENST00000559703HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-intronENST00000472863ENST00000559710HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-intronENST00000476342ENST00000559703HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-intronENST00000476342ENST00000559710HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-intronENST00000552000ENST00000559703HOXB3chr17

46651199

-TCF12chr15

57523350

+
intron-intronENST00000552000ENST00000559710HOXB3chr17

46651199

-TCF12chr15

57523350

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000490677HOXB3chr1746651199-ENST00000438423TCF12chr1557523350+40981871421728528
ENST00000490677HOXB3chr1746651199-ENST00000267811TCF12chr1557523350+53651871421656504
ENST00000490677HOXB3chr1746651199-ENST00000452095TCF12chr1557523350+40981871421728528
ENST00000490677HOXB3chr1746651199-ENST00000333725TCF12chr1557523350+40921871421728528
ENST00000490677HOXB3chr1746651199-ENST00000557843TCF12chr1557523350+35971871421656504

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000490677ENST00000438423HOXB3chr1746651199-TCF12chr1557523350+0.000855260.9991447
ENST00000490677ENST00000267811HOXB3chr1746651199-TCF12chr1557523350+0.0003216070.9996784
ENST00000490677ENST00000452095HOXB3chr1746651199-TCF12chr1557523350+0.000855260.9991447
ENST00000490677ENST00000333725HOXB3chr1746651199-TCF12chr1557523350+0.000864220.9991358
ENST00000490677ENST00000557843HOXB3chr1746651199-TCF12chr1557523350+0.001071370.9989286

Top

Fusion Genomic Features for HOXB3-TCF12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HOXB3chr1746651198-TCF12chr1557523349+0.0013486450.9986513
HOXB3chr1746651198-TCF12chr1557523349+0.0013486450.9986513

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for HOXB3-TCF12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:46651199/chr15:57523350)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HOXB3

P14651

.
FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTCF12chr17:46651199chr15:57523350ENST00000267811720577_6301931821.3333333333333DomainbHLH
TgeneTCF12chr17:46651199chr15:57523350ENST00000333725721577_6301931420.0DomainbHLH
TgeneTCF12chr17:46651199chr15:57523350ENST00000343827013577_630231254.6666666666667DomainbHLH
TgeneTCF12chr17:46651199chr15:57523350ENST00000438423721577_6301931398.3333333333333DomainbHLH
TgeneTCF12chr17:46651199chr15:57523350ENST00000557843720577_6301931301.0DomainbHLH
TgeneTCF12chr17:46651199chr15:57523350ENST00000267811720632_6551931821.3333333333333RegionNote=Class A specific domain
TgeneTCF12chr17:46651199chr15:57523350ENST00000333725721632_6551931420.0RegionNote=Class A specific domain
TgeneTCF12chr17:46651199chr15:57523350ENST00000343827013119_140231254.6666666666667RegionNote=Leucine-zipper
TgeneTCF12chr17:46651199chr15:57523350ENST00000343827013632_655231254.6666666666667RegionNote=Class A specific domain
TgeneTCF12chr17:46651199chr15:57523350ENST00000438423721632_6551931398.3333333333333RegionNote=Class A specific domain
TgeneTCF12chr17:46651199chr15:57523350ENST00000557843720632_6551931301.0RegionNote=Class A specific domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHOXB3chr17:46651199chr15:57523350ENST00000311626-14154_1780432.0Compositional biasNote=Gly-rich
HgeneHOXB3chr17:46651199chr15:57523350ENST00000470495-12154_1780432.0Compositional biasNote=Gly-rich
HgeneHOXB3chr17:46651199chr15:57523350ENST00000476342-13154_1780432.0Compositional biasNote=Gly-rich
HgeneHOXB3chr17:46651199chr15:57523350ENST00000498678-25154_1780432.0Compositional biasNote=Gly-rich
HgeneHOXB3chr17:46651199chr15:57523350ENST00000311626-14188_2470432.0DNA bindingHomeobox
HgeneHOXB3chr17:46651199chr15:57523350ENST00000470495-12188_2470432.0DNA bindingHomeobox
HgeneHOXB3chr17:46651199chr15:57523350ENST00000476342-13188_2470432.0DNA bindingHomeobox
HgeneHOXB3chr17:46651199chr15:57523350ENST00000498678-25188_2470432.0DNA bindingHomeobox
HgeneHOXB3chr17:46651199chr15:57523350ENST00000311626-14129_1340432.0MotifNote=Antp-type hexapeptide
HgeneHOXB3chr17:46651199chr15:57523350ENST00000470495-12129_1340432.0MotifNote=Antp-type hexapeptide
HgeneHOXB3chr17:46651199chr15:57523350ENST00000476342-13129_1340432.0MotifNote=Antp-type hexapeptide
HgeneHOXB3chr17:46651199chr15:57523350ENST00000498678-25129_1340432.0MotifNote=Antp-type hexapeptide
TgeneTCF12chr17:46651199chr15:57523350ENST0000026781172019_271931821.3333333333333MotifNote=9aaTAD
TgeneTCF12chr17:46651199chr15:57523350ENST0000033372572119_271931420.0MotifNote=9aaTAD
TgeneTCF12chr17:46651199chr15:57523350ENST0000034382701319_27231254.6666666666667MotifNote=9aaTAD
TgeneTCF12chr17:46651199chr15:57523350ENST0000043842372119_271931398.3333333333333MotifNote=9aaTAD
TgeneTCF12chr17:46651199chr15:57523350ENST0000055784372019_271931301.0MotifNote=9aaTAD
TgeneTCF12chr17:46651199chr15:57523350ENST00000267811720119_1401931821.3333333333333RegionNote=Leucine-zipper
TgeneTCF12chr17:46651199chr15:57523350ENST00000333725721119_1401931420.0RegionNote=Leucine-zipper
TgeneTCF12chr17:46651199chr15:57523350ENST00000438423721119_1401931398.3333333333333RegionNote=Leucine-zipper
TgeneTCF12chr17:46651199chr15:57523350ENST00000557843720119_1401931301.0RegionNote=Leucine-zipper


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Fusion Gene Sequence for HOXB3-TCF12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37433_37433_1_HOXB3-TCF12_HOXB3_chr17_46651199_ENST00000490677_TCF12_chr15_57523350_ENST00000267811_length(transcript)=5365nt_BP=187nt
ATTCAACAGCAAATCTCCTTGGACCGGCTGTTGGGGGAAAAAAGTGTTAGCCGTCTCTCCCGGATCTGCAAGGGGGAAAAAATTTGGAAC
CATAAAGTTGAAAACTTTTTTCTCTCAGTTTGGAAGAAGCCCTTCGTCATGAATGGGATCTGCAGAGTTCGGGCGAGAGGAGGCGAGAGG
CGCAAAGGTATATGCACCATCCCCAAATTCAGATGATTTCAACCGTGAATCTCCTAGTTATCCATCTCCTAAGCCACCAACCAGTATGTT
CGCTAGCACTTTCTTTATGCAAGATGGGACCCACAATTCTTCTGACCTTTGGAGTTCATCAAATGGGATGAGCCAGCCTGGTTTTGGTGG
AATTCTGGGGACCTCCACTTCCCACATGTCTCAATCCAGTAGTTATGGCAACCTTCATTCACATGACCGCTTGAGTTATCCTCCACACTC
AGTTTCACCAACAGACATAAACACGAGTCTTCCACCAATGTCCAGCTTTCATCGCGGCAGTACCAGCAGTTCACCTTACGTTGCTGCCTC
ACACACTCCTCCCATCAATGGATCAGACAGCATTCTAGGAACCAGAGGGAATGCTGCTGGAAGCTCACAGACAGGTGATGCACTTGGAAA
GGCTTTGGCATCTATTTATTCTCCTGACCATACCAGCAGTAGTTTTCCGTCAAATCCATCAACACCAGTTGGATCACCTTCACCTCTCAC
AGGTACCAGTCAGTGGCCAAGACCTGGAGGGCAAGCACCTTCATCCCCAAGCTATGAAAACTCACTCCACTCCCTGCAGTCTCGAATGGA
GGATCGTTTAGACAGACTGGATGATGCAATCCATGTGCTGCGGAACCATGCTGTGGGACCTTCCACCAGTTTGCCTGCTGGTCACAGTGA
TATACATAGTTTATTGGGACCATCCCATAATGCACCAATTGGAAGCCTCAATTCAAACTATGGAGGATCAAGCCTTGTTGCAAGCAGTCG
ATCAGCTTCAATGGTTGGAACTCATCGGGAAGACTCTGTCAGTCTCAATGGCAATCATTCAGTCCTGTCTAGTACAGTCACTACTTCAAG
CACAGACCTGAACCATAAAACACAAGAAAATTATAGAGGTGGCTTGCAAAGTCAGTCTGGAACTGTTGTTACAACAGAAATCAAGACTGA
AAACAAAGAAAAGGATGAAAACCTTCATGAACCTCCTTCATCAGATGACATGAAGTCAGATGATGAATCCTCCCAAAAAGATATCAAGGT
TTCATCTAGAGGCAGAACAAGCAGTACTAATGAAGATGAGGATTTGAACCCTGAACAGAAGATAGAAAGGGAGAAGGAGAGGCGGATGGC
TAACAATGCCAGAGAACGCTTACGCGTGCGGGATATTAATGAAGCATTCAAAGAGCTTGGCCGAATGTGTCAGCTTCACTTGAAGAGTGA
AAAACCCCAAACAAAACTCCTTATTCTTCATCAAGCCGTGGCAGTCATCCTTAGTCTAGAACAGCAAGTCAGAGAGAGGAACCTTAACCC
CAAAGCAGCCTGCCTTAAGAGAAGGGAAGAAGAAAAAGTTTCTGCCGTATCGGCAGAGCCGCCAACCACACTGCCAGGAACCCATCCTGG
GCTTAGTGAAACTACCAACCCTATGGGTCATATGTAAACATCAGCCAGTTCCAGAGTTATCAGTAGGCTAGATAGAAGGTGACCTCTCCT
CATAAGGACTTGGACAACTCAGATTATCTGAAGACACAAACCTGACAGGAGGGAGAAGAAAAAACAAAACACTTGAACCAAGAAACTCAA
ATGTAATCCTACGATCAAAGCAACTGGTCAACACTTCCATCAGAAGTGAAGATAGGAAGCTCATCAGATAGAACATCAGCCCATGAGATG
TTTGCAACAAATCTTTTGTTGCAAGCAGTGTGTCGCTTCTGCACAATCAGAGACTGTCTCGATCTCTCCACTCACCGTGGAAGTTGCCTT
GTGCCTAAACTGAATTGACAAATGCATTGTAACTACAAATTTTATTTATTGTTATGAAACTGTAAGGTCTACATATAAAGGGAAAAAGTT
AATGTGGAAAGCTGATCTACACTCAGCTGATGCCAGCATACATTAAAGCGGTTCACGTGCAGAGAACAAAGCAGTGACAACCATTGGCCC
TTAGCATTCCCGGCATACCTATTAGTGTCTTAAAAAGGAAGGGAAAAGTCTTTTGTTGCCCTCTCCTATCCTCTTGCCATATGAATAGCG
TTTTCCATGAAATAGGAAAATATTACTTGGTATAGCATTTCTCTTGCTCTCATTTTTTGATTTATTTTTATTTTCTCTTTGTGGGTGTTA
TATTTGATCTCTAAATCTGAACAGTTTATGGTCACAGTCCAGCCTCCTCCGTGCAGCCCTGTGTGCTTTGCACATTTACCTTACAGTGGT
AAGCAGAGACCATCTGTGACCATAGCCTAGCTAGCATTTTAAAAGGGGAAATTTTGTTCTCTAGGTTTTCCCCCAAATAAACATTGCTTT
ATTTCTAATAATAACCAAGACTTTTCAAGCTTCTAGATCTCATAGGAAAGCTTGTAATAGCAAAATTGTAAATTACAAGGGAAGAATCTA
CTTTTTAGAAATCGCTTTGTTTTCCAAGCAGTAAGTACTACATACAGTACTTGTAAAGTGTTAGCTGTAAGTAAGCACAAAATACATTTA
AAATACAAAGACGATTTTTTCAGGCTGTGATTATGGTGAACATAACAAAACCCAGTAGTCACCAAGGCAGGTAGTGTGATAAATGAACAC
ACCACTCTGAGGCTAATTACCTAATGGAATACAAGAGCAATGGTCACCCGTATTTCCTTATCCTAGCCTTTATTTCTCTGTCATTTGGAT
GGCTGGTCAATGGGGAAGAATTGAGTGGGTGATTTAATCAACTGCAAACCATCTGCCCCTGTCCCAAAATGATGAGCCAGATTAGCATTA
AACCAGTACTTGTCAGTCCATCTTAATACTGTTCATTAAGGCACTCTCTGTCTCTAATCCTTAGGAGTTGTTTTAAAAGACATAATCACT
TTGAACTTCCATGAAACCTGTCTTCCACCACAACAACCCTGGGAGAGAAAAACATGCTAAAGGAGGTATCTTGGCTTAATAATTCCTTAT
AGCCAATATCAACAGTGGCAATCAGCACACAGAGGAAAGGACCCAAATCACTATGTAGCTTAAAGATTTCTGTTAATTTGAAAGAACAAA
AACAAGACAGAACTTCTGGTACTCTAATCAGGATGATTCCTAACAAGTCAGTCATTTGTGAACTTAGTGGACTTTTTGGTTACTTTAATT
TGCATATATTCTCCAGTTACATCGGACTCTATCTGTGGCCTTGTTCTTCATTTCAGTGTTAATCAGCTAAACAGAAGTTGTTGCTTATGA
TGTGTGAGTGAACATATGCCACTGCCTGGCCTTTTTTTCTTCAGAGCTTGTTGTCTTTTTCGCTATATTAGACTTTGCAGTATGCCCAGA
AGCTTTCCTTCATAAAATAGAAAGAAAAAAACATTTGGCTTATTTTTCACTGTAGCTAGTCTTTTATACAATAATCTTGTAAGAAAATTT
CTTGAATTCTAAATATTACTCTTTCTAGATTTTTGAAATCAAAAAGTTTTCAGTAAAAAGTTTCTTACTTTATTTTATTATATTAGGTAG
TAAAAAATGTAGGGTTATTTACCATAACCTGTTCATTAATATCAGAAATTTACAATAGCATTTTAAGACCATAGTAGGATTCTAGCATAC
CGTGTAGTACCTATGGAGTATTGTAAGAGCTAATTGTTGGAGATGAATTGCTTCTCATCTTGTTCTCCAGTTTCCATTGTTGGTTTATTG
CAGATTTGTATCCTGTGTCAAATTCAAGGTATTATTGATAAACCTTTTCAACCAGCAGCAAGAAGTTCAAATTTTTTTCTGTCACTGTAA
CAGAAAACACAATATGTATATAACATTTATGTAGCAATAAATGTGCCATCTTTTTTTTAACACAGTAAAATAGTGAGTTTTTTACATTTC
TCTTTCTCAAATAATAATGTATTTTGTTTTATTTTCTCCATCTCATTCGTCCCAGAAACACTCACACTGCTTTTCCTAACTGCATTACCG
ACATTATCTGGGAAACCCTTCAGGACAGAATCAGGCTTGTGGAGCTAAGTTGGCAATCTGGTCTAGAGCTTCTCTAGCTTGTGCTTTTCT
CCTCTTGCCCTCACTACTGACGGTGGCCTTTTAACCTTTTCCTAAAGATTGACCAAACAGCAACTAGTAGTTATAGAAAATCTACTCATT
TGTAGATACAGAGAAAAATGAAGAAGATGGAAAAAGACTCAAAAGAGGCTTTTTAAGTTATTCTTCAAAGCACTTTTCACATTTCCCCAT
ACCCTTTCTCACAAAAAAAGTGTCATAATTAAGTAATGGTATTGTTTACTGTTTAAAAGTTAAAAGATCAAAAATTTGCTTTTATCCCAG
TTTTTAACCACAAAAAAAAGCGTAGGGATTATCCATGAGGACTTCATGCCAAGCAAGAACCTCAAACAAACTAGACAAACTTTTTTTTTG
ACAGTGAATGACTTTTTGTAGGACCTGTGCGTGCGAAACCCATGGCAATTGTCACATCCTCTTGGTATGCTGGCAGATTGCTTCTCTTGG
TGAATTATGAAATCCACTGTTCACATTGGGTGCCTAACAGAACATTTTGCTTCTTGTGGGATTTAGTGAAAACTATTAAACTTGTTAAGT
TGATTTTATACAAAACGATAAATAAAAAGCTCTAAGAAGAAAATGTATAATCTTAGAGCTGAAATAAAATATAGAGACCATCTAGTAAAT
GACCTCATTAATATATCTGTGAAAACTGAGACTCAGATTGTATGTCTCTAAGAACACATAATTAGTAACAGATCAAGACACTTAAAACTT
TCCCTACAAAACCTCCCTGCCTTGACTTTCTCTTTCTCTTTGCAGATTTCTAGGCCGCTTCTGCTCAGTGTCTTCATTTTCTTCCATATT
TGTTTTATTTCATTTTTCTTTTCTATAGTTCATGTTTTCTTTTTCCTTGGAAACTCAAAATTTAAACACACGTCGTGTGTGTGTGTGTGT
GTGTGTCTGTGTGTGTGTGACTTAAAGAATCTTAAGCTTTGGCATTAAATAGTCCTCGATTCAAATCTAAGCTCAACATCTGATTAACTT
CATTTTCCTATCTGAAAAATGGAGATAACATTAGAATTGTGTAAGTATTGAATGAAACAATGTATGGAAAGCTCTTATGGTTCTTGTCAC

>37433_37433_1_HOXB3-TCF12_HOXB3_chr17_46651199_ENST00000490677_TCF12_chr15_57523350_ENST00000267811_length(amino acids)=504AA_BP=14
MGSAEFGREEARGAKVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGN
LHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPS
NPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLN
SNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENLHEPPSSDDM
KSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVIL

--------------------------------------------------------------
>37433_37433_2_HOXB3-TCF12_HOXB3_chr17_46651199_ENST00000490677_TCF12_chr15_57523350_ENST00000333725_length(transcript)=4092nt_BP=187nt
ATTCAACAGCAAATCTCCTTGGACCGGCTGTTGGGGGAAAAAAGTGTTAGCCGTCTCTCCCGGATCTGCAAGGGGGAAAAAATTTGGAAC
CATAAAGTTGAAAACTTTTTTCTCTCAGTTTGGAAGAAGCCCTTCGTCATGAATGGGATCTGCAGAGTTCGGGCGAGAGGAGGCGAGAGG
CGCAAAGGTATATGCACCATCCCCAAATTCAGATGATTTCAACCGTGAATCTCCTAGTTATCCATCTCCTAAGCCACCAACCAGTATGTT
CGCTAGCACTTTCTTTATGCAAGATGGGACCCACAATTCTTCTGACCTTTGGAGTTCATCAAATGGGATGAGCCAGCCTGGTTTTGGTGG
AATTCTGGGGACCTCCACTTCCCACATGTCTCAATCCAGTAGTTATGGCAACCTTCATTCACATGACCGCTTGAGTTATCCTCCACACTC
AGTTTCACCAACAGACATAAACACGAGTCTTCCACCAATGTCCAGCTTTCATCGCGGCAGTACCAGCAGTTCACCTTACGTTGCTGCCTC
ACACACTCCTCCCATCAATGGATCAGACAGCATTCTAGGAACCAGAGGGAATGCTGCTGGAAGCTCACAGACAGGTGATGCACTTGGAAA
GGCTTTGGCATCTATTTATTCTCCTGACCATACCAGCAGTAGTTTTCCGTCAAATCCATCAACACCAGTTGGATCACCTTCACCTCTCAC
AGGTACCAGTCAGTGGCCAAGACCTGGAGGGCAAGCACCTTCATCCCCAAGCTATGAAAACTCACTCCACTCCCTGAAAAATCGAGTTGA
GCAGCAACTTCACGAGCATTTGCAAGATGCAATGTCCTTCTTAAAGGATGTCTGTGAGCAGTCTCGAATGGAGGATCGTTTAGACAGACT
GGATGATGCAATCCATGTGCTGCGGAACCATGCTGTGGGACCTTCCACCAGTTTGCCTGCTGGTCACAGTGATATACATAGTTTATTGGG
ACCATCCCATAATGCACCAATTGGAAGCCTCAATTCAAACTATGGAGGATCAAGCCTTGTTGCAAGCAGTCGATCAGCTTCAATGGTTGG
AACTCATCGGGAAGACTCTGTCAGTCTCAATGGCAATCATTCAGTCCTGTCTAGTACAGTCACTACTTCAAGCACAGACCTGAACCATAA
AACACAAGAAAATTATAGAGGTGGCTTGCAAAGTCAGTCTGGAACTGTTGTTACAACAGAAATCAAGACTGAAAACAAAGAAAAGGATGA
AAACCTTCATGAACCTCCTTCATCAGATGACATGAAGTCAGATGATGAATCCTCCCAAAAAGATATCAAGGTTTCATCTAGAGGCAGAAC
AAGCAGTACTAATGAAGATGAGGATTTGAACCCTGAACAGAAGATAGAAAGGGAGAAGGAGAGGCGGATGGCTAACAATGCCAGAGAACG
CTTACGCGTGCGGGATATTAATGAAGCATTCAAAGAGCTTGGCCGAATGTGTCAGCTTCACTTGAAGAGTGAAAAACCCCAAACAAAACT
CCTTATTCTTCATCAAGCCGTGGCAGTCATCCTTAGTCTAGAACAGCAAGTCAGAGAGAGGAACCTTAACCCCAAAGCAGCCTGCCTTAA
GAGAAGGGAAGAAGAAAAAGTTTCTGCCGTATCGGCAGAGCCGCCAACCACACTGCCAGGAACCCATCCTGGGCTTAGTGAAACTACCAA
CCCTATGGGTCATATGTAAACATCAGCCAGTTCCAGAGTTATCAGTAGGCTAGATAGAAGGTGACCTCTCCTCATAAGGACTTGGACAAC
TCAGATTATCTGAAGACACAAACCTGACAGGAGGGAGAAGAAAAAACAAAACACTTGAACCAAGAAACTCAAATGTAATCCTACGATCAA
AGCAACTGGTCAACACTTCCATCAGAAGTGAAGATAGGAAGCTCATCAGATAGAACATCAGCCCATGAGATGTTTGCAACAAATCTTTTG
TTGCAAGCAGTGTGTCGCTTCTGCACAATCAGAGACTGTCTCGATCTCTCCACTCACCGTGGAAGTTGCCTTGTGCCTAAACTGAATTGA
CAAATGCATTGTAACTACAAATTTTATTTATTGTTATGAAACTGTAAGGTCTACATATAAAGGGAAAAAGTTAATGTGGAAAGCTGATCT
ACACTCAGCTGATGCCAGCATACATTAAAGCGGTTCACGTGCAGAGAACAAAGCAGTGACAACCATTGGCCCTTAGCATTCCCGGCATAC
CTATTAGTGTCTTAAAAAGGAAGGGAAAAGTCTTTTGTTGCCCTCTCCTATCCTCTTGCCATATGAATAGCGTTTTCCATGAAATAGGAA
AATATTACTTGGTATAGCATTTCTCTTGCTCTCATTTTTTGATTTATTTTTATTTTCTCTTTGTGGGTGTTATATTTGATCTCTAAATCT
GAACAGTTTATGGTCACAGTCCAGCCTCCTCCGTGCAGCCCTGTGTGCTTTGCACATTTACCTTACAGTGGTAAGCAGAGACCATCTGTG
ACCATAGCCTAGCTAGCATTTTAAAAGGGGAAATTTTGTTCTCTAGGTTTTCCCCCAAATAAACATTGCTTTATTTCTAATAATAACCAA
GACTTTTCAAGCTTCTAGATCTCATAGGAAAGCTTGTAATAGCAAAATTGTAAATTACAAGGGAAGAATCTACTTTTTAGAAATCGCTTT
GTTTTCCAAGCAGTAAGTACTACATACAGTACTTGTAAAGTGTTAGCTGTAAGTAAGCACAAAATACATTTAAAATACAAAGACGATTTT
TTCAGGCTGTGATTATGGTGAACATAACAAAACCCAGTAGTCACCAAGGCAGGTAGTGTGATAAATGAACACACCACTCTGAGGCTAATT
ACCTAATGGAATACAAGAGCAATGGTCACCCGTATTTCCTTATCCTAGCCTTTATTTCTCTGTCATTTGGATGGCTGGTCAATGGGGAAG
AATTGAGTGGGTGATTTAATCAACTGCAAACCATCTGCCCCTGTCCCAAAATGATGAGCCAGATTAGCATTAAACCAGTACTTGTCAGTC
CATCTTAATACTGTTCATTAAGGCACTCTCTGTCTCTAATCCTTAGGAGTTGTTTTAAAAGACATAATCACTTTGAACTTCCATGAAACC
TGTCTTCCACCACAACAACCCTGGGAGAGAAAAACATGCTAAAGGAGGTATCTTGGCTTAATAATTCCTTATAGCCAATATCAACAGTGG
CAATCAGCACACAGAGGAAAGGACCCAAATCACTATGTAGCTTAAAGATTTCTGTTAATTTGAAAGAACAAAAACAAGACAGAACTTCTG
GTACTCTAATCAGGATGATTCCTAACAAGTCAGTCATTTGTGAACTTAGTGGACTTTTTGGTTACTTTAATTTGCATATATTCTCCAGTT
ACATCGGACTCTATCTGTGGCCTTGTTCTTCATTTCAGTGTTAATCAGCTAAACAGAAGTTGTTGCTTATGATGTGTGAGTGAACATATG
CCACTGCCTGGCCTTTTTTTCTTCAGAGCTTGTTGTCTTTTTCGCTATATTAGACTTTGCAGTATGCCCAGAAGCTTTCCTTCATAAAAT
AGAAAGAAAAAAACATTTGGCTTATTTTTCACTGTAGCTAGTCTTTTATACAATAATCTTGTAAGAAAATTTCTTGAATTCTAAATATTA
CTCTTTCTAGATTTTTGAAATCAAAAAGTTTTCAGTAAAAAGTTTCTTACTTTATTTTATTATATTAGGTAGTAAAAAATGTAGGGTTAT
TTACCATAACCTGTTCATTAATATCAGAAATTTACAATAGCATTTTAAGACCATAGTAGGATTCTAGCATACCGTGTAGTACCTATGGAG
TATTGTAAGAGCTAATTGTTGGAGATGAATTGCTTCTCATCTTGTTCTCCAGTTTCCATTGTTGGTTTATTGCAGATTTGTATCCTGTGT
CAAATTCAAGGTATTATTGATAAACCTTTTCAACCAGCAGCAAGAAGTTCAAATTTTTTTCTGTCACTGTAACAGAAAACACAATATGTA

>37433_37433_2_HOXB3-TCF12_HOXB3_chr17_46651199_ENST00000490677_TCF12_chr15_57523350_ENST00000333725_length(amino acids)=528AA_BP=14
MGSAEFGREEARGAKVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGN
LHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPS
NPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHAVGPSTS
LPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVV
TTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMC

--------------------------------------------------------------
>37433_37433_3_HOXB3-TCF12_HOXB3_chr17_46651199_ENST00000490677_TCF12_chr15_57523350_ENST00000438423_length(transcript)=4098nt_BP=187nt
ATTCAACAGCAAATCTCCTTGGACCGGCTGTTGGGGGAAAAAAGTGTTAGCCGTCTCTCCCGGATCTGCAAGGGGGAAAAAATTTGGAAC
CATAAAGTTGAAAACTTTTTTCTCTCAGTTTGGAAGAAGCCCTTCGTCATGAATGGGATCTGCAGAGTTCGGGCGAGAGGAGGCGAGAGG
CGCAAAGGTATATGCACCATCCCCAAATTCAGATGATTTCAACCGTGAATCTCCTAGTTATCCATCTCCTAAGCCACCAACCAGTATGTT
CGCTAGCACTTTCTTTATGCAAGATGGGACCCACAATTCTTCTGACCTTTGGAGTTCATCAAATGGGATGAGCCAGCCTGGTTTTGGTGG
AATTCTGGGGACCTCCACTTCCCACATGTCTCAATCCAGTAGTTATGGCAACCTTCATTCACATGACCGCTTGAGTTATCCTCCACACTC
AGTTTCACCAACAGACATAAACACGAGTCTTCCACCAATGTCCAGCTTTCATCGCGGCAGTACCAGCAGTTCACCTTACGTTGCTGCCTC
ACACACTCCTCCCATCAATGGATCAGACAGCATTCTAGGAACCAGAGGGAATGCTGCTGGAAGCTCACAGACAGGTGATGCACTTGGAAA
GGCTTTGGCATCTATTTATTCTCCTGACCATACCAGCAGTAGTTTTCCGTCAAATCCATCAACACCAGTTGGATCACCTTCACCTCTCAC
AGGTACCAGTCAGTGGCCAAGACCTGGAGGGCAAGCACCTTCATCCCCAAGCTATGAAAACTCACTCCACTCCCTGAAAAATCGAGTTGA
GCAGCAACTTCACGAGCATTTGCAAGATGCAATGTCCTTCTTAAAGGATGTCTGTGAGCAGTCTCGAATGGAGGATCGTTTAGACAGACT
GGATGATGCAATCCATGTGCTGCGGAACCATGCTGTGGGACCTTCCACCAGTTTGCCTGCTGGTCACAGTGATATACATAGTTTATTGGG
ACCATCCCATAATGCACCAATTGGAAGCCTCAATTCAAACTATGGAGGATCAAGCCTTGTTGCAAGCAGTCGATCAGCTTCAATGGTTGG
AACTCATCGGGAAGACTCTGTCAGTCTCAATGGCAATCATTCAGTCCTGTCTAGTACAGTCACTACTTCAAGCACAGACCTGAACCATAA
AACACAAGAAAATTATAGAGGTGGCTTGCAAAGTCAGTCTGGAACTGTTGTTACAACAGAAATCAAGACTGAAAACAAAGAAAAGGATGA
AAACCTTCATGAACCTCCTTCATCAGATGACATGAAGTCAGATGATGAATCCTCCCAAAAAGATATCAAGGTTTCATCTAGAGGCAGAAC
AAGCAGTACTAATGAAGATGAGGATTTGAACCCTGAACAGAAGATAGAAAGGGAGAAGGAGAGGCGGATGGCTAACAATGCCAGAGAACG
CTTACGCGTGCGGGATATTAATGAAGCATTCAAAGAGCTTGGCCGAATGTGTCAGCTTCACTTGAAGAGTGAAAAACCCCAAACAAAACT
CCTTATTCTTCATCAAGCCGTGGCAGTCATCCTTAGTCTAGAACAGCAAGTCAGAGAGAGGAACCTTAACCCCAAAGCAGCCTGCCTTAA
GAGAAGGGAAGAAGAAAAAGTTTCTGCCGTATCGGCAGAGCCGCCAACCACACTGCCAGGAACCCATCCTGGGCTTAGTGAAACTACCAA
CCCTATGGGTCATATGTAAACATCAGCCAGTTCCAGAGTTATCAGTAGGCTAGATAGAAGGTGACCTCTCCTCATAAGGACTTGGACAAC
TCAGATTATCTGAAGACACAAACCTGACAGGAGGGAGAAGAAAAAACAAAACACTTGAACCAAGAAACTCAAATGTAATCCTACGATCAA
AGCAACTGGTCAACACTTCCATCAGAAGTGAAGATAGGAAGCTCATCAGATAGAACATCAGCCCATGAGATGTTTGCAACAAATCTTTTG
TTGCAAGCAGTGTGTCGCTTCTGCACAATCAGAGACTGTCTCGATCTCTCCACTCACCGTGGAAGTTGCCTTGTGCCTAAACTGAATTGA
CAAATGCATTGTAACTACAAATTTTATTTATTGTTATGAAACTGTAAGGTCTACATATAAAGGGAAAAAGTTAATGTGGAAAGCTGATCT
ACACTCAGCTGATGCCAGCATACATTAAAGCGGTTCACGTGCAGAGAACAAAGCAGTGACAACCATTGGCCCTTAGCATTCCCGGCATAC
CTATTAGTGTCTTAAAAAGGAAGGGAAAAGTCTTTTGTTGCCCTCTCCTATCCTCTTGCCATATGAATAGCGTTTTCCATGAAATAGGAA
AATATTACTTGGTATAGCATTTCTCTTGCTCTCATTTTTTGATTTATTTTTATTTTCTCTTTGTGGGTGTTATATTTGATCTCTAAATCT
GAACAGTTTATGGTCACAGTCCAGCCTCCTCCGTGCAGCCCTGTGTGCTTTGCACATTTACCTTACAGTGGTAAGCAGAGACCATCTGTG
ACCATAGCCTAGCTAGCATTTTAAAAGGGGAAATTTTGTTCTCTAGGTTTTCCCCCAAATAAACATTGCTTTATTTCTAATAATAACCAA
GACTTTTCAAGCTTCTAGATCTCATAGGAAAGCTTGTAATAGCAAAATTGTAAATTACAAGGGAAGAATCTACTTTTTAGAAATCGCTTT
GTTTTCCAAGCAGTAAGTACTACATACAGTACTTGTAAAGTGTTAGCTGTAAGTAAGCACAAAATACATTTAAAATACAAAGACGATTTT
TTCAGGCTGTGATTATGGTGAACATAACAAAACCCAGTAGTCACCAAGGCAGGTAGTGTGATAAATGAACACACCACTCTGAGGCTAATT
ACCTAATGGAATACAAGAGCAATGGTCACCCGTATTTCCTTATCCTAGCCTTTATTTCTCTGTCATTTGGATGGCTGGTCAATGGGGAAG
AATTGAGTGGGTGATTTAATCAACTGCAAACCATCTGCCCCTGTCCCAAAATGATGAGCCAGATTAGCATTAAACCAGTACTTGTCAGTC
CATCTTAATACTGTTCATTAAGGCACTCTCTGTCTCTAATCCTTAGGAGTTGTTTTAAAAGACATAATCACTTTGAACTTCCATGAAACC
TGTCTTCCACCACAACAACCCTGGGAGAGAAAAACATGCTAAAGGAGGTATCTTGGCTTAATAATTCCTTATAGCCAATATCAACAGTGG
CAATCAGCACACAGAGGAAAGGACCCAAATCACTATGTAGCTTAAAGATTTCTGTTAATTTGAAAGAACAAAAACAAGACAGAACTTCTG
GTACTCTAATCAGGATGATTCCTAACAAGTCAGTCATTTGTGAACTTAGTGGACTTTTTGGTTACTTTAATTTGCATATATTCTCCAGTT
ACATCGGACTCTATCTGTGGCCTTGTTCTTCATTTCAGTGTTAATCAGCTAAACAGAAGTTGTTGCTTATGATGTGTGAGTGAACATATG
CCACTGCCTGGCCTTTTTTTCTTCAGAGCTTGTTGTCTTTTTCGCTATATTAGACTTTGCAGTATGCCCAGAAGCTTTCCTTCATAAAAT
AGAAAGAAAAAAACATTTGGCTTATTTTTCACTGTAGCTAGTCTTTTATACAATAATCTTGTAAGAAAATTTCTTGAATTCTAAATATTA
CTCTTTCTAGATTTTTGAAATCAAAAAGTTTTCAGTAAAAAGTTTCTTACTTTATTTTATTATATTAGGTAGTAAAAAATGTAGGGTTAT
TTACCATAACCTGTTCATTAATATCAGAAATTTACAATAGCATTTTAAGACCATAGTAGGATTCTAGCATACCGTGTAGTACCTATGGAG
TATTGTAAGAGCTAATTGTTGGAGATGAATTGCTTCTCATCTTGTTCTCCAGTTTCCATTGTTGGTTTATTGCAGATTTGTATCCTGTGT
CAAATTCAAGGTATTATTGATAAACCTTTTCAACCAGCAGCAAGAAGTTCAAATTTTTTTCTGTCACTGTAACAGAAAACACAATATGTA

>37433_37433_3_HOXB3-TCF12_HOXB3_chr17_46651199_ENST00000490677_TCF12_chr15_57523350_ENST00000438423_length(amino acids)=528AA_BP=14
MGSAEFGREEARGAKVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGN
LHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPS
NPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHAVGPSTS
LPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVV
TTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMC

--------------------------------------------------------------
>37433_37433_4_HOXB3-TCF12_HOXB3_chr17_46651199_ENST00000490677_TCF12_chr15_57523350_ENST00000452095_length(transcript)=4098nt_BP=187nt
ATTCAACAGCAAATCTCCTTGGACCGGCTGTTGGGGGAAAAAAGTGTTAGCCGTCTCTCCCGGATCTGCAAGGGGGAAAAAATTTGGAAC
CATAAAGTTGAAAACTTTTTTCTCTCAGTTTGGAAGAAGCCCTTCGTCATGAATGGGATCTGCAGAGTTCGGGCGAGAGGAGGCGAGAGG
CGCAAAGGTATATGCACCATCCCCAAATTCAGATGATTTCAACCGTGAATCTCCTAGTTATCCATCTCCTAAGCCACCAACCAGTATGTT
CGCTAGCACTTTCTTTATGCAAGATGGGACCCACAATTCTTCTGACCTTTGGAGTTCATCAAATGGGATGAGCCAGCCTGGTTTTGGTGG
AATTCTGGGGACCTCCACTTCCCACATGTCTCAATCCAGTAGTTATGGCAACCTTCATTCACATGACCGCTTGAGTTATCCTCCACACTC
AGTTTCACCAACAGACATAAACACGAGTCTTCCACCAATGTCCAGCTTTCATCGCGGCAGTACCAGCAGTTCACCTTACGTTGCTGCCTC
ACACACTCCTCCCATCAATGGATCAGACAGCATTCTAGGAACCAGAGGGAATGCTGCTGGAAGCTCACAGACAGGTGATGCACTTGGAAA
GGCTTTGGCATCTATTTATTCTCCTGACCATACCAGCAGTAGTTTTCCGTCAAATCCATCAACACCAGTTGGATCACCTTCACCTCTCAC
AGGTACCAGTCAGTGGCCAAGACCTGGAGGGCAAGCACCTTCATCCCCAAGCTATGAAAACTCACTCCACTCCCTGAAAAATCGAGTTGA
GCAGCAACTTCACGAGCATTTGCAAGATGCAATGTCCTTCTTAAAGGATGTCTGTGAGCAGTCTCGAATGGAGGATCGTTTAGACAGACT
GGATGATGCAATCCATGTGCTGCGGAACCATGCTGTGGGACCTTCCACCAGTTTGCCTGCTGGTCACAGTGATATACATAGTTTATTGGG
ACCATCCCATAATGCACCAATTGGAAGCCTCAATTCAAACTATGGAGGATCAAGCCTTGTTGCAAGCAGTCGATCAGCTTCAATGGTTGG
AACTCATCGGGAAGACTCTGTCAGTCTCAATGGCAATCATTCAGTCCTGTCTAGTACAGTCACTACTTCAAGCACAGACCTGAACCATAA
AACACAAGAAAATTATAGAGGTGGCTTGCAAAGTCAGTCTGGAACTGTTGTTACAACAGAAATCAAGACTGAAAACAAAGAAAAGGATGA
AAACCTTCATGAACCTCCTTCATCAGATGACATGAAGTCAGATGATGAATCCTCCCAAAAAGATATCAAGGTTTCATCTAGAGGCAGAAC
AAGCAGTACTAATGAAGATGAGGATTTGAACCCTGAACAGAAGATAGAAAGGGAGAAGGAGAGGCGGATGGCTAACAATGCCAGAGAACG
CTTACGCGTGCGGGATATTAATGAAGCATTCAAAGAGCTTGGCCGAATGTGTCAGCTTCACTTGAAGAGTGAAAAACCCCAAACAAAACT
CCTTATTCTTCATCAAGCCGTGGCAGTCATCCTTAGTCTAGAACAGCAAGTCAGAGAGAGGAACCTTAACCCCAAAGCAGCCTGCCTTAA
GAGAAGGGAAGAAGAAAAAGTTTCTGCCGTATCGGCAGAGCCGCCAACCACACTGCCAGGAACCCATCCTGGGCTTAGTGAAACTACCAA
CCCTATGGGTCATATGTAAACATCAGCCAGTTCCAGAGTTATCAGTAGGCTAGATAGAAGGTGACCTCTCCTCATAAGGACTTGGACAAC
TCAGATTATCTGAAGACACAAACCTGACAGGAGGGAGAAGAAAAAACAAAACACTTGAACCAAGAAACTCAAATGTAATCCTACGATCAA
AGCAACTGGTCAACACTTCCATCAGAAGTGAAGATAGGAAGCTCATCAGATAGAACATCAGCCCATGAGATGTTTGCAACAAATCTTTTG
TTGCAAGCAGTGTGTCGCTTCTGCACAATCAGAGACTGTCTCGATCTCTCCACTCACCGTGGAAGTTGCCTTGTGCCTAAACTGAATTGA
CAAATGCATTGTAACTACAAATTTTATTTATTGTTATGAAACTGTAAGGTCTACATATAAAGGGAAAAAGTTAATGTGGAAAGCTGATCT
ACACTCAGCTGATGCCAGCATACATTAAAGCGGTTCACGTGCAGAGAACAAAGCAGTGACAACCATTGGCCCTTAGCATTCCCGGCATAC
CTATTAGTGTCTTAAAAAGGAAGGGAAAAGTCTTTTGTTGCCCTCTCCTATCCTCTTGCCATATGAATAGCGTTTTCCATGAAATAGGAA
AATATTACTTGGTATAGCATTTCTCTTGCTCTCATTTTTTGATTTATTTTTATTTTCTCTTTGTGGGTGTTATATTTGATCTCTAAATCT
GAACAGTTTATGGTCACAGTCCAGCCTCCTCCGTGCAGCCCTGTGTGCTTTGCACATTTACCTTACAGTGGTAAGCAGAGACCATCTGTG
ACCATAGCCTAGCTAGCATTTTAAAAGGGGAAATTTTGTTCTCTAGGTTTTCCCCCAAATAAACATTGCTTTATTTCTAATAATAACCAA
GACTTTTCAAGCTTCTAGATCTCATAGGAAAGCTTGTAATAGCAAAATTGTAAATTACAAGGGAAGAATCTACTTTTTAGAAATCGCTTT
GTTTTCCAAGCAGTAAGTACTACATACAGTACTTGTAAAGTGTTAGCTGTAAGTAAGCACAAAATACATTTAAAATACAAAGACGATTTT
TTCAGGCTGTGATTATGGTGAACATAACAAAACCCAGTAGTCACCAAGGCAGGTAGTGTGATAAATGAACACACCACTCTGAGGCTAATT
ACCTAATGGAATACAAGAGCAATGGTCACCCGTATTTCCTTATCCTAGCCTTTATTTCTCTGTCATTTGGATGGCTGGTCAATGGGGAAG
AATTGAGTGGGTGATTTAATCAACTGCAAACCATCTGCCCCTGTCCCAAAATGATGAGCCAGATTAGCATTAAACCAGTACTTGTCAGTC
CATCTTAATACTGTTCATTAAGGCACTCTCTGTCTCTAATCCTTAGGAGTTGTTTTAAAAGACATAATCACTTTGAACTTCCATGAAACC
TGTCTTCCACCACAACAACCCTGGGAGAGAAAAACATGCTAAAGGAGGTATCTTGGCTTAATAATTCCTTATAGCCAATATCAACAGTGG
CAATCAGCACACAGAGGAAAGGACCCAAATCACTATGTAGCTTAAAGATTTCTGTTAATTTGAAAGAACAAAAACAAGACAGAACTTCTG
GTACTCTAATCAGGATGATTCCTAACAAGTCAGTCATTTGTGAACTTAGTGGACTTTTTGGTTACTTTAATTTGCATATATTCTCCAGTT
ACATCGGACTCTATCTGTGGCCTTGTTCTTCATTTCAGTGTTAATCAGCTAAACAGAAGTTGTTGCTTATGATGTGTGAGTGAACATATG
CCACTGCCTGGCCTTTTTTTCTTCAGAGCTTGTTGTCTTTTTCGCTATATTAGACTTTGCAGTATGCCCAGAAGCTTTCCTTCATAAAAT
AGAAAGAAAAAAACATTTGGCTTATTTTTCACTGTAGCTAGTCTTTTATACAATAATCTTGTAAGAAAATTTCTTGAATTCTAAATATTA
CTCTTTCTAGATTTTTGAAATCAAAAAGTTTTCAGTAAAAAGTTTCTTACTTTATTTTATTATATTAGGTAGTAAAAAATGTAGGGTTAT
TTACCATAACCTGTTCATTAATATCAGAAATTTACAATAGCATTTTAAGACCATAGTAGGATTCTAGCATACCGTGTAGTACCTATGGAG
TATTGTAAGAGCTAATTGTTGGAGATGAATTGCTTCTCATCTTGTTCTCCAGTTTCCATTGTTGGTTTATTGCAGATTTGTATCCTGTGT
CAAATTCAAGGTATTATTGATAAACCTTTTCAACCAGCAGCAAGAAGTTCAAATTTTTTTCTGTCACTGTAACAGAAAACACAATATGTA

>37433_37433_4_HOXB3-TCF12_HOXB3_chr17_46651199_ENST00000490677_TCF12_chr15_57523350_ENST00000452095_length(amino acids)=528AA_BP=14
MGSAEFGREEARGAKVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGN
LHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPS
NPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHAVGPSTS
LPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVV
TTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMC

--------------------------------------------------------------
>37433_37433_5_HOXB3-TCF12_HOXB3_chr17_46651199_ENST00000490677_TCF12_chr15_57523350_ENST00000557843_length(transcript)=3597nt_BP=187nt
ATTCAACAGCAAATCTCCTTGGACCGGCTGTTGGGGGAAAAAAGTGTTAGCCGTCTCTCCCGGATCTGCAAGGGGGAAAAAATTTGGAAC
CATAAAGTTGAAAACTTTTTTCTCTCAGTTTGGAAGAAGCCCTTCGTCATGAATGGGATCTGCAGAGTTCGGGCGAGAGGAGGCGAGAGG
CGCAAAGGTATATGCACCATCCCCAAATTCAGATGATTTCAACCGTGAATCTCCTAGTTATCCATCTCCTAAGCCACCAACCAGTATGTT
CGCTAGCACTTTCTTTATGCAAGATGGGACCCACAATTCTTCTGACCTTTGGAGTTCATCAAATGGGATGAGCCAGCCTGGTTTTGGTGG
AATTCTGGGGACCTCCACTTCCCACATGTCTCAATCCAGTAGTTATGGCAACCTTCATTCACATGACCGCTTGAGTTATCCTCCACACTC
AGTTTCACCAACAGACATAAACACGAGTCTTCCACCAATGTCCAGCTTTCATCGCGGCAGTACCAGCAGTTCACCTTACGTTGCTGCCTC
ACACACTCCTCCCATCAATGGATCAGACAGCATTCTAGGAACCAGAGGGAATGCTGCTGGAAGCTCACAGACAGGTGATGCACTTGGAAA
GGCTTTGGCATCTATTTATTCTCCTGACCATACCAGCAGTAGTTTTCCGTCAAATCCATCAACACCAGTTGGATCACCTTCACCTCTCAC
AGGTACCAGTCAGTGGCCAAGACCTGGAGGGCAAGCACCTTCATCCCCAAGCTATGAAAACTCACTCCACTCCCTGCAGTCTCGAATGGA
GGATCGTTTAGACAGACTGGATGATGCAATCCATGTGCTGCGGAACCATGCTGTGGGACCTTCCACCAGTTTGCCTGCTGGTCACAGTGA
TATACATAGTTTATTGGGACCATCCCATAATGCACCAATTGGAAGCCTCAATTCAAACTATGGAGGATCAAGCCTTGTTGCAAGCAGTCG
ATCAGCTTCAATGGTTGGAACTCATCGGGAAGACTCTGTCAGTCTCAATGGCAATCATTCAGTCCTGTCTAGTACAGTCACTACTTCAAG
CACAGACCTGAACCATAAAACACAAGAAAATTATAGAGGTGGCTTGCAAAGTCAGTCTGGAACTGTTGTTACAACAGAAATCAAGACTGA
AAACAAAGAAAAGGATGAAAACCTTCATGAACCTCCTTCATCAGATGACATGAAGTCAGATGATGAATCCTCCCAAAAAGATATCAAGGT
TTCATCTAGAGGCAGAACAAGCAGTACTAATGAAGATGAGGATTTGAACCCTGAACAGAAGATAGAAAGGGAGAAGGAGAGGCGGATGGC
TAACAATGCCAGAGAACGCTTACGCGTGCGGGATATTAATGAAGCATTCAAAGAGCTTGGCCGAATGTGTCAGCTTCACTTGAAGAGTGA
AAAACCCCAAACAAAACTCCTTATTCTTCATCAAGCCGTGGCAGTCATCCTTAGTCTAGAACAGCAAGTCAGAGAGAGGAACCTTAACCC
CAAAGCAGCCTGCCTTAAGAGAAGGGAAGAAGAAAAAGTTTCTGCCGTATCGGCAGAGCCGCCAACCACACTGCCAGGAACCCATCCTGG
GCTTAGTGAAACTACCAACCCTATGGGTCATATGTAAACATCAGCCAGTTCCAGAGTTATCAGTAGGCTAGATAGAAGGTGACCTCTCCT
CATAAGGACTTGGACAACTCAGATTATCTGAAGACACAAACCTGACAGGAGGGAGAAGAAAAAACAAAACACTTGAACCAAGAAACTCAA
ATGTAATCCTACGATCAAAGCAACTGGTCAACACTTCCATCAGAAGTGAAGATAGGAAGCTCATCAGATAGAACATCAGCCCATGAGATG
TTTGCAACAAATCTTTTGTTGCAAGCAGTGTGTCGCTTCTGCACAATCAGAGACTGTCTCGATCTCTCCACTCACCGTGGAAGTTGCCTT
GTGCCTAAACTGAATTGACAAATGCATTGTAACTACAAATTTTATTTATTGTTATGAAACTGTAAGGTCTACATATAAAGGGAAAAAGTT
AATGTGGAAAGCTGATCTACACTCAGCTGATGCCAGCATACATTAAAGCGGTTCACGTGCAGAGAACAAAGCAGTGACAACCATTGGCCC
TTAGCATTCCCGGCATACCTATTAGTGTCTTAAAAAGGAAGGGAAAAGTCTTTTGTTGCCCTCTCCTATCCTCTTGCCATATGAATAGCG
TTTTCCATGAAATAGGAAAATATTACTTGGTATAGCATTTCTCTTGCTCTCATTTTTTGATTTATTTTTATTTTCTCTTTGTGGGTGTTA
TATTTGATCTCTAAATCTGAACAGTTTATGGTCACAGTCCAGCCTCCTCCGTGCAGCCCTGTGTGCTTTGCACATTTACCTTACAGTGGT
AAGCAGAGACCATCTGTGACCATAGCCTAGCTAGCATTTTAAAAGGGGAAATTTTGTTCTCTAGGTTTTCCCCCAAATAAACATTGCTTT
ATTTCTAATAATAACCAAGACTTTTCAAGCTTCTAGATCTCATAGGAAAGCTTGTAATAGCAAAATTGTAAATTACAAGGGAAGAATCTA
CTTTTTAGAAATCGCTTTGTTTTCCAAGCAGTAAGTACTACATACAGTACTTGTAAAGTGTTAGCTGTAAGTAAGCACAAAATACATTTA
AAATACAAAGACGATTTTTTCAGGCTGTGATTATGGTGAACATAACAAAACCCAGTAGTCACCAAGGCAGGTAGTGTGATAAATGAACAC
ACCACTCTGAGGCTAATTACCTAATGGAATACAAGAGCAATGGTCACCCGTATTTCCTTATCCTAGCCTTTATTTCTCTGTCATTTGGAT
GGCTGGTCAATGGGGAAGAATTGAGTGGGTGATTTAATCAACTGCAAACCATCTGCCCCTGTCCCAAAATGATGAGCCAGATTAGCATTA
AACCAGTACTTGTCAGTCCATCTTAATACTGTTCATTAAGGCACTCTCTGTCTCTAATCCTTAGGAGTTGTTTTAAAAGACATAATCACT
TTGAACTTCCATGAAACCTGTCTTCCACCACAACAACCCTGGGAGAGAAAAACATGCTAAAGGAGGTATCTTGGCTTAATAATTCCTTAT
AGCCAATATCAACAGTGGCAATCAGCACACAGAGGAAAGGACCCAAATCACTATGTAGCTTAAAGATTTCTGTTAATTTGAAAGAACAAA
AACAAGACAGAACTTCTGGTACTCTAATCAGGATGATTCCTAACAAGTCAGTCATTTGTGAACTTAGTGGACTTTTTGGTTACTTTAATT
TGCATATATTCTCCAGTTACATCGGACTCTATCTGTGGCCTTGTTCTTCATTTCAGTGTTAATCAGCTAAACAGAAGTTGTTGCTTATGA
TGTGTGAGTGAACATATGCCACTGCCTGGCCTTTTTTTCTTCAGAGCTTGTTGTCTTTTTCGCTATATTAGACTTTGCAGTATGCCCAGA

>37433_37433_5_HOXB3-TCF12_HOXB3_chr17_46651199_ENST00000490677_TCF12_chr15_57523350_ENST00000557843_length(amino acids)=504AA_BP=14
MGSAEFGREEARGAKVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGN
LHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPS
NPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLN
SNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENLHEPPSSDDM
KSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVIL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HOXB3-TCF12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTCF12chr17:46651199chr15:57523350ENST00000343827013182_19623.01254.6666666666667RUNX1T1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneTCF12chr17:46651199chr15:57523350ENST00000267811720182_196193.01821.3333333333333RUNX1T1
TgeneTCF12chr17:46651199chr15:57523350ENST00000333725721182_196193.01420.0RUNX1T1
TgeneTCF12chr17:46651199chr15:57523350ENST00000438423721182_196193.01398.3333333333333RUNX1T1
TgeneTCF12chr17:46651199chr15:57523350ENST00000557843720182_196193.01301.0RUNX1T1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HOXB3-TCF12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HOXB3-TCF12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource