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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HP-CFB (FusionGDB2 ID:37494)

Fusion Gene Summary for HP-CFB

Fusion gene summary

Fusion gene information	Fusion gene name: HP-CFB
	Fusion gene ID: 37494
		Hgene	Tgene
	Gene symbol	HP	CFB
	Gene ID	10395	629
	Gene name	DLC1 Rho GTPase activating protein	complement factor B
	Synonyms	ARHGAP7\|HP\|STARD12\|p122-RhoGAP	AHUS4\|ARMD14\|BF\|BFD\|CFAB\|CFBD\|FB\|FBI12\|GBG\|H2-Bf\|PBF2
	Cytomap	8p22	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer varia	complement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor B
	Modification date	20200313	20200327
	UniProtAcc	.	P00751
	Ensembl transtripts involved in fusion gene	ENST00000355906, ENST00000357763, ENST00000398131, ENST00000562526, ENST00000569639, ENST00000570083, ENST00000565574,	ENST00000375455, ENST00000399981, ENST00000417261, ENST00000419411, ENST00000419920, ENST00000424727, ENST00000426239, ENST00000427888, ENST00000433503, ENST00000436692, ENST00000455591, ENST00000459734, ENST00000460958, ENST00000465211, ENST00000473139, ENST00000474621, ENST00000489605, ENST00000497841, ENST00000425368, ENST00000456570, ENST00000477310, ENST00000556679,
Fusion gene scores	* DoF score	9 X 11 X 3=297	17 X 11 X 9=1683
	# samples	10	20
	** MAII score	log2(10/297*10)=-1.57046293102604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(20/1683*10)=-3.07296327155522 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HP [Title/Abstract] AND CFB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HP(72093066)-CFB(31918944), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HP	GO:0006915	apoptotic process	17292327
Hgene	HP	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	17888903
Hgene	HP	GO:0008285	negative regulation of cell proliferation	12545165\|17932950
Hgene	HP	GO:0030336	negative regulation of cell migration	17932950\|19158340
Hgene	HP	GO:0035307	positive regulation of protein dephosphorylation	17292327
Hgene	HP	GO:0051497	negative regulation of stress fiber assembly	17932950
Hgene	HP	GO:0051895	negative regulation of focal adhesion assembly	19158340
Hgene	HP	GO:1900119	positive regulation of execution phase of apoptosis	17888903

Fusion gene breakpoints across HP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CFB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BC007464	HP	chr16	72093066	+	CFB	chr6	31918944	+

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Fusion Gene ORF analysis for HP-CFB

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000355906	ENST00000375455	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000399981	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000417261	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000419411	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000419920	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000424727	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000426239	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000427888	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000433503	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000436692	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000455591	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000459734	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000460958	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000465211	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000473139	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000474621	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000489605	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000355906	ENST00000497841	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000375455	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000399981	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000417261	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000419411	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000419920	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000424727	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000426239	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000427888	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000433503	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000436692	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000455591	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000459734	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000460958	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000465211	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000473139	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000474621	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000489605	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000357763	ENST00000497841	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000375455	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000399981	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000417261	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000419411	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000419920	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000424727	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000426239	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000427888	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000433503	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000436692	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000455591	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000459734	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000460958	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000465211	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000473139	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000474621	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000489605	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000398131	ENST00000497841	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000375455	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000399981	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000417261	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000419411	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000419920	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000424727	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000426239	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000427888	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000433503	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000436692	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000455591	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000459734	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000460958	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000465211	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000473139	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000474621	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000489605	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000562526	ENST00000497841	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000375455	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000399981	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000417261	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000419411	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000419920	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000424727	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000426239	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000427888	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000433503	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000436692	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000455591	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000459734	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000460958	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000465211	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000473139	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000474621	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000489605	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000569639	ENST00000497841	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000375455	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000399981	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000417261	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000419411	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000419920	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000424727	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000426239	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000427888	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000433503	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000436692	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000455591	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000459734	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000460958	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000465211	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000473139	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000474621	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000489605	HP	chr16	72093066	+	CFB	chr6	31918944	+
5CDS-intron	ENST00000570083	ENST00000497841	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000355906	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000355906	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000355906	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000355906	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000357763	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000357763	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000357763	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000357763	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000398131	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000398131	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000398131	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000398131	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000562526	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000562526	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000562526	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000562526	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000569639	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000569639	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000569639	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000569639	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000570083	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000570083	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000570083	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+
In-frame	ENST00000570083	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-3CDS	ENST00000565574	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-3CDS	ENST00000565574	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-3CDS	ENST00000565574	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-3CDS	ENST00000565574	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000375455	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000399981	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000417261	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000419411	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000419920	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000424727	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000426239	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000427888	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000433503	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000436692	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000455591	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000459734	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000460958	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000465211	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000473139	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000474621	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000489605	HP	chr16	72093066	+	CFB	chr6	31918944	+
intron-intron	ENST00000565574	ENST00000497841	HP	chr16	72093066	+	CFB	chr6	31918944	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000570083	HP	chr16	72093066	+	ENST00000556679	CFB	chr6	31918944	+	706	272	19	687	222
ENST00000570083	HP	chr16	72093066	+	ENST00000456570	CFB	chr6	31918944	+	706	272	19	687	222
ENST00000570083	HP	chr16	72093066	+	ENST00000477310	CFB	chr6	31918944	+	688	272	19	687	223
ENST00000570083	HP	chr16	72093066	+	ENST00000425368	CFB	chr6	31918944	+	742	272	19	687	222
ENST00000355906	HP	chr16	72093066	+	ENST00000556679	CFB	chr6	31918944	+	880	446	16	861	281
ENST00000355906	HP	chr16	72093066	+	ENST00000456570	CFB	chr6	31918944	+	880	446	16	861	281
ENST00000355906	HP	chr16	72093066	+	ENST00000477310	CFB	chr6	31918944	+	862	446	16	861	282
ENST00000355906	HP	chr16	72093066	+	ENST00000425368	CFB	chr6	31918944	+	916	446	16	861	281
ENST00000398131	HP	chr16	72093066	+	ENST00000556679	CFB	chr6	31918944	+	689	255	2	670	222
ENST00000398131	HP	chr16	72093066	+	ENST00000456570	CFB	chr6	31918944	+	689	255	2	670	222
ENST00000398131	HP	chr16	72093066	+	ENST00000477310	CFB	chr6	31918944	+	671	255	2	670	223
ENST00000398131	HP	chr16	72093066	+	ENST00000425368	CFB	chr6	31918944	+	725	255	2	670	222
ENST00000569639	HP	chr16	72093066	+	ENST00000556679	CFB	chr6	31918944	+	948	514	525	929	134
ENST00000569639	HP	chr16	72093066	+	ENST00000456570	CFB	chr6	31918944	+	948	514	525	929	134
ENST00000569639	HP	chr16	72093066	+	ENST00000477310	CFB	chr6	31918944	+	930	514	525	929	134
ENST00000569639	HP	chr16	72093066	+	ENST00000425368	CFB	chr6	31918944	+	984	514	525	929	134
ENST00000357763	HP	chr16	72093066	+	ENST00000556679	CFB	chr6	31918944	+	957	523	27	938	303
ENST00000357763	HP	chr16	72093066	+	ENST00000456570	CFB	chr6	31918944	+	957	523	27	938	303
ENST00000357763	HP	chr16	72093066	+	ENST00000477310	CFB	chr6	31918944	+	939	523	27	938	303
ENST00000357763	HP	chr16	72093066	+	ENST00000425368	CFB	chr6	31918944	+	993	523	27	938	303
ENST00000562526	HP	chr16	72093066	+	ENST00000556679	CFB	chr6	31918944	+	672	238	27	653	208
ENST00000562526	HP	chr16	72093066	+	ENST00000456570	CFB	chr6	31918944	+	672	238	27	653	208
ENST00000562526	HP	chr16	72093066	+	ENST00000477310	CFB	chr6	31918944	+	654	238	27	653	208
ENST00000562526	HP	chr16	72093066	+	ENST00000425368	CFB	chr6	31918944	+	708	238	27	653	208

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000570083	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005928626	0.9940713
ENST00000570083	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005928626	0.9940713
ENST00000570083	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.00612938	0.9938706
ENST00000570083	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.00604317	0.9939568
ENST00000355906	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005954868	0.99404514
ENST00000355906	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005954868	0.99404514
ENST00000355906	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.006346113	0.9936539
ENST00000355906	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005616536	0.99438345
ENST00000398131	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.006201833	0.9937982
ENST00000398131	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.006201833	0.9937982
ENST00000398131	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.006546828	0.99345315
ENST00000398131	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005950078	0.9940499
ENST00000569639	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.15452811	0.84547186
ENST00000569639	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.15452811	0.84547186
ENST00000569639	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.15270771	0.8472923
ENST00000569639	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.16190442	0.8380956
ENST00000357763	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.003077754	0.9969222
ENST00000357763	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.003077754	0.9969222
ENST00000357763	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.003192858	0.9968072
ENST00000357763	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.002920458	0.9970796
ENST00000562526	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005132796	0.9948672
ENST00000562526	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005132796	0.9948672
ENST00000562526	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005287633	0.99471235
ENST00000562526	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.004720376	0.99527967

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Fusion Genomic Features for HP-CFB

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HP-CFB

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:72093066/chr6:31918944)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CFB P00751
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000399981

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000399981

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000399981

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000399981

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000399981

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000417261

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000417261

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000417261

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000417261

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000417261

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419411

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419411

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419411

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419411

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419411

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419920

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419920

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419920

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419920

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419920

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000424727

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000424727

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000424727

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000424727

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000424727

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000425368

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000425368

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000425368

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000425368

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000425368

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000426239

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000426239

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000426239

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000426239

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000426239

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000427888

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000427888

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000427888

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000427888

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000427888

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000433503

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000433503

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000433503

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000433503

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000433503

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000436692

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000436692

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000436692

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000436692

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000436692

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000455591

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000455591

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000455591

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000455591

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000455591

477_757

765.0

Domain

Peptidase S1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

chr16:72093066

chr6:31918944

ENST00000355906

162_404

407.0

Domain

Peptidase S1

Hgene

chr16:72093066

chr6:31918944

ENST00000355906

31_88

407.0

Domain

Sushi 1

Hgene

chr16:72093066

chr6:31918944

ENST00000355906

90_147

407.0

Domain

Sushi 2

Hgene

chr16:72093066

chr6:31918944

ENST00000398131

162_404

348.0

Domain

Peptidase S1

Hgene

chr16:72093066

chr6:31918944

ENST00000398131

31_88

348.0

Domain

Sushi 1

Hgene

chr16:72093066

chr6:31918944

ENST00000398131

90_147

348.0

Domain

Sushi 2

Hgene

chr16:72093066

chr6:31918944

ENST00000565574

162_404

348.0

Domain

Peptidase S1

Hgene

chr16:72093066

chr6:31918944

ENST00000565574

31_88

348.0

Domain

Sushi 1

Hgene

chr16:72093066

chr6:31918944

ENST00000565574

90_147

348.0

Domain

Sushi 2

Hgene

chr16:72093066

chr6:31918944

ENST00000570083

162_404

348.0

Domain

Peptidase S1

Hgene

chr16:72093066

chr6:31918944

ENST00000570083

31_88

348.0

Domain

Sushi 1

Hgene

chr16:72093066

chr6:31918944

ENST00000570083

90_147

348.0

Domain

Sushi 2

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Fusion Gene Sequence for HP-CFB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>37494_37494_1_HP-CFB_HP_chr16_72093066_ENST00000355906_CFB_chr6_31918944_ENST00000425368_length(transcript)=916nt_BP=446nt
ATAAAAAGACCAGCAGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCT
GCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACA
TGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGGAGTATACACCTTAAATGATAA
GAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGG
CTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGATAT
CAAAGCTCTGTTTGTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAG
AGATGCTCAATATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCC
CTATGCTGACCCCAATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAG
CTGGGGAGTAGTGGATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGT
GCTGCCCTGGCTGAAGGAGAAACTCCAAGATGAGGATTTGGGTTTTCTATAAGGGGTTTCCTGCTGGACAGGGGCGTGGGATTGAATTAA

>37494_37494_1_HP-CFB_HP_chr16_72093066_ENST00000355906_CFB_chr6_31918944_ENST00000425368_length(amino acids)=281AA_BP=143
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWIN
KAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYA
PGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLK

--------------------------------------------------------------
>37494_37494_2_HP-CFB_HP_chr16_72093066_ENST00000355906_CFB_chr6_31918944_ENST00000456570_length(transcript)=880nt_BP=446nt
ATAAAAAGACCAGCAGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCT
GCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACA
TGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGGAGTATACACCTTAAATGATAA
GAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGG
CTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGATAT
CAAAGCTCTGTTTGTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAG
AGATGCTCAATATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCC
CTATGCTGACCCCAATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAG
CTGGGGAGTAGTGGATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGT

>37494_37494_2_HP-CFB_HP_chr16_72093066_ENST00000355906_CFB_chr6_31918944_ENST00000456570_length(amino acids)=281AA_BP=143
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWIN
KAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYA
PGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLK

--------------------------------------------------------------
>37494_37494_3_HP-CFB_HP_chr16_72093066_ENST00000355906_CFB_chr6_31918944_ENST00000477310_length(transcript)=862nt_BP=446nt
ATAAAAAGACCAGCAGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCT
GCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACA
TGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGGAGTATACACCTTAAATGATAA
GAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGG
CTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGATAT
CAAAGCTCTGTTTGTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAG
AGATGCTCAATATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCC
CTATGCTGACCCCAATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAG
CTGGGGAGTAGTGGATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGT

>37494_37494_3_HP-CFB_HP_chr16_72093066_ENST00000355906_CFB_chr6_31918944_ENST00000477310_length(amino acids)=282AA_BP=143
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWIN
KAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYA
PGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLK

--------------------------------------------------------------
>37494_37494_4_HP-CFB_HP_chr16_72093066_ENST00000355906_CFB_chr6_31918944_ENST00000556679_length(transcript)=880nt_BP=446nt
ATAAAAAGACCAGCAGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCT
GCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACA
TGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGGAGTATACACCTTAAATGATAA
GAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGG
CTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGATAT
CAAAGCTCTGTTTGTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAG
AGATGCTCAATATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCC
CTATGCTGACCCCAATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAG
CTGGGGAGTAGTGGATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGT

>37494_37494_4_HP-CFB_HP_chr16_72093066_ENST00000355906_CFB_chr6_31918944_ENST00000556679_length(amino acids)=281AA_BP=143
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWIN
KAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYA
PGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLK

--------------------------------------------------------------
>37494_37494_5_HP-CFB_HP_chr16_72093066_ENST00000357763_CFB_chr6_31918944_ENST00000425368_length(transcript)=993nt_BP=523nt
GCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCA
GGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAG
TGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGGAGTATACACCTTAAATGATAAGAAGCAGTGGATAAATAAGGCTGTTGGAGAT
AAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGT
AAGAACTACTACAAACTGCGCACAGAAGGAGATGGGGAGGCGATGCCATGCAGCCTACCTCATGTAAATCTCAGAGTCACATTTACATCT
CCAGCAGATGTGGGAAAAGAAGGAATGCTGATGATGATGTCACCCTCACCTAAACTTCCTGAATGTGAAGCAGATATCAAAGCTCTGTTT
GTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATAT
GCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCC
AATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTG
GATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTG
AAGGAGAAACTCCAAGATGAGGATTTGGGTTTTCTATAAGGGGTTTCCTGCTGGACAGGGGCGTGGGATTGAATTAAAACAGCTGCGACA

>37494_37494_5_HP-CFB_HP_chr16_72093066_ENST00000357763_CFB_chr6_31918944_ENST00000425368_length(amino acids)=303AA_BP=165
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADD
GCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGEAMPCSLPHVNLRVTFTSPADVGKEGMLMMMSPSPKLPECEADIKALFVSEEEKKLT
RKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQ

--------------------------------------------------------------
>37494_37494_6_HP-CFB_HP_chr16_72093066_ENST00000357763_CFB_chr6_31918944_ENST00000456570_length(transcript)=957nt_BP=523nt
GCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCA
GGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAG
TGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGGAGTATACACCTTAAATGATAAGAAGCAGTGGATAAATAAGGCTGTTGGAGAT
AAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGT
AAGAACTACTACAAACTGCGCACAGAAGGAGATGGGGAGGCGATGCCATGCAGCCTACCTCATGTAAATCTCAGAGTCACATTTACATCT
CCAGCAGATGTGGGAAAAGAAGGAATGCTGATGATGATGTCACCCTCACCTAAACTTCCTGAATGTGAAGCAGATATCAAAGCTCTGTTT
GTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATAT
GCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCC
AATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTG
GATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTG

>37494_37494_6_HP-CFB_HP_chr16_72093066_ENST00000357763_CFB_chr6_31918944_ENST00000456570_length(amino acids)=303AA_BP=165
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADD
GCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGEAMPCSLPHVNLRVTFTSPADVGKEGMLMMMSPSPKLPECEADIKALFVSEEEKKLT
RKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQ

--------------------------------------------------------------
>37494_37494_7_HP-CFB_HP_chr16_72093066_ENST00000357763_CFB_chr6_31918944_ENST00000477310_length(transcript)=939nt_BP=523nt
GCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCA
GGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAG
TGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGGAGTATACACCTTAAATGATAAGAAGCAGTGGATAAATAAGGCTGTTGGAGAT
AAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGT
AAGAACTACTACAAACTGCGCACAGAAGGAGATGGGGAGGCGATGCCATGCAGCCTACCTCATGTAAATCTCAGAGTCACATTTACATCT
CCAGCAGATGTGGGAAAAGAAGGAATGCTGATGATGATGTCACCCTCACCTAAACTTCCTGAATGTGAAGCAGATATCAAAGCTCTGTTT
GTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATAT
GCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCC
AATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTG
GATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTG

>37494_37494_7_HP-CFB_HP_chr16_72093066_ENST00000357763_CFB_chr6_31918944_ENST00000477310_length(amino acids)=303AA_BP=165
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADD
GCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGEAMPCSLPHVNLRVTFTSPADVGKEGMLMMMSPSPKLPECEADIKALFVSEEEKKLT
RKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQ

--------------------------------------------------------------
>37494_37494_8_HP-CFB_HP_chr16_72093066_ENST00000357763_CFB_chr6_31918944_ENST00000556679_length(transcript)=957nt_BP=523nt
GCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCA
GGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAG
TGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGGAGTATACACCTTAAATGATAAGAAGCAGTGGATAAATAAGGCTGTTGGAGAT
AAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGT
AAGAACTACTACAAACTGCGCACAGAAGGAGATGGGGAGGCGATGCCATGCAGCCTACCTCATGTAAATCTCAGAGTCACATTTACATCT
CCAGCAGATGTGGGAAAAGAAGGAATGCTGATGATGATGTCACCCTCACCTAAACTTCCTGAATGTGAAGCAGATATCAAAGCTCTGTTT
GTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATAT
GCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCC
AATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTG
GATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTG

>37494_37494_8_HP-CFB_HP_chr16_72093066_ENST00000357763_CFB_chr6_31918944_ENST00000556679_length(amino acids)=303AA_BP=165
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADD
GCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGEAMPCSLPHVNLRVTFTSPADVGKEGMLMMMSPSPKLPECEADIKALFVSEEEKKLT
RKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQ

--------------------------------------------------------------
>37494_37494_9_HP-CFB_HP_chr16_72093066_ENST00000398131_CFB_chr6_31918944_ENST00000425368_length(transcript)=725nt_BP=255nt
AGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGC
TTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGC
ACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGATATCAAAGCTCTGT
TTGTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAAT
ATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACC
CCAATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAG
TGGATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGC
TGAAGGAGAAACTCCAAGATGAGGATTTGGGTTTTCTATAAGGGGTTTCCTGCTGGACAGGGGCGTGGGATTGAATTAAAACAGCTGCGA

>37494_37494_9_HP-CFB_HP_chr16_72093066_ENST00000398131_CFB_chr6_31918944_ENST00000425368_length(amino acids)=222AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------
>37494_37494_10_HP-CFB_HP_chr16_72093066_ENST00000398131_CFB_chr6_31918944_ENST00000456570_length(transcript)=689nt_BP=255nt
AGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGC
TTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGC
ACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGATATCAAAGCTCTGT
TTGTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAAT
ATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACC
CCAATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAG
TGGATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGC

>37494_37494_10_HP-CFB_HP_chr16_72093066_ENST00000398131_CFB_chr6_31918944_ENST00000456570_length(amino acids)=222AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------
>37494_37494_11_HP-CFB_HP_chr16_72093066_ENST00000398131_CFB_chr6_31918944_ENST00000477310_length(transcript)=671nt_BP=255nt
AGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGC
TTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGC
ACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGATATCAAAGCTCTGT
TTGTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAAT
ATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACC
CCAATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAG
TGGATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGC

>37494_37494_11_HP-CFB_HP_chr16_72093066_ENST00000398131_CFB_chr6_31918944_ENST00000477310_length(amino acids)=223AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------
>37494_37494_12_HP-CFB_HP_chr16_72093066_ENST00000398131_CFB_chr6_31918944_ENST00000556679_length(transcript)=689nt_BP=255nt
AGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGC
TTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGC
ACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGATATCAAAGCTCTGT
TTGTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAAT
ATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACC
CCAATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAG
TGGATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGC

>37494_37494_12_HP-CFB_HP_chr16_72093066_ENST00000398131_CFB_chr6_31918944_ENST00000556679_length(amino acids)=222AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------
>37494_37494_13_HP-CFB_HP_chr16_72093066_ENST00000562526_CFB_chr6_31918944_ENST00000425368_length(transcript)=708nt_BP=238nt
GCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCA
GGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAG
TGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGATATCAAAGCTCTGTTTGTGTCTGAGGAGGAG
AAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATATGCCCCAGGCTATGAC
AAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCCAATACTTGCAGAGGT
GATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTGGATGTCTGCAAAAAC
CAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTGAAGGAGAAACTCCAA

>37494_37494_13_HP-CFB_HP_chr16_72093066_ENST00000562526_CFB_chr6_31918944_ENST00000425368_length(amino acids)=208AA_BP=70
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVY
IKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPA

--------------------------------------------------------------
>37494_37494_14_HP-CFB_HP_chr16_72093066_ENST00000562526_CFB_chr6_31918944_ENST00000456570_length(transcript)=672nt_BP=238nt
GCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCA
GGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAG
TGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGATATCAAAGCTCTGTTTGTGTCTGAGGAGGAG
AAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATATGCCCCAGGCTATGAC
AAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCCAATACTTGCAGAGGT
GATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTGGATGTCTGCAAAAAC
CAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTGAAGGAGAAACTCCAA

>37494_37494_14_HP-CFB_HP_chr16_72093066_ENST00000562526_CFB_chr6_31918944_ENST00000456570_length(amino acids)=208AA_BP=70
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVY
IKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPA

--------------------------------------------------------------
>37494_37494_15_HP-CFB_HP_chr16_72093066_ENST00000562526_CFB_chr6_31918944_ENST00000477310_length(transcript)=654nt_BP=238nt
GCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCA
GGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAG
TGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGATATCAAAGCTCTGTTTGTGTCTGAGGAGGAG
AAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATATGCCCCAGGCTATGAC
AAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCCAATACTTGCAGAGGT
GATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTGGATGTCTGCAAAAAC
CAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTGAAGGAGAAACTCCAA

>37494_37494_15_HP-CFB_HP_chr16_72093066_ENST00000562526_CFB_chr6_31918944_ENST00000477310_length(amino acids)=208AA_BP=70
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVY
IKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPA

--------------------------------------------------------------
>37494_37494_16_HP-CFB_HP_chr16_72093066_ENST00000562526_CFB_chr6_31918944_ENST00000556679_length(transcript)=672nt_BP=238nt
GCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCA
GGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAG
TGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGATATCAAAGCTCTGTTTGTGTCTGAGGAGGAG
AAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATATGCCCCAGGCTATGAC
AAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCCAATACTTGCAGAGGT
GATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTGGATGTCTGCAAAAAC
CAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTGAAGGAGAAACTCCAA

>37494_37494_16_HP-CFB_HP_chr16_72093066_ENST00000562526_CFB_chr6_31918944_ENST00000556679_length(amino acids)=208AA_BP=70
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVY
IKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPA

--------------------------------------------------------------
>37494_37494_17_HP-CFB_HP_chr16_72093066_ENST00000569639_CFB_chr6_31918944_ENST00000425368_length(transcript)=984nt_BP=514nt
ACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGAC
TCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTAC
CAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGGTGGGTGCTGAGCACTTAAGAGAGCAGGC
AGGCGTCCAGCGGGGAACGTCCTAGAGGCACAGCCTTCCAGTGCGGCTTCCTCTGAGCACACAAGAGCCAGGAGGAGGGATGTGGGAGAA
CCGCAGCTGGCCAGGGAGAGACTTAAGCAGTTAGGTGATGACTCCCTAAGGGTCACCAAGGGTCTTGTTCATTAGGGCCTGAAGGGCACT
GGCTGAATCCATTGTCTACATCGCCCACAGATTAGGAGAGCCTGTGCATACAGAGAGCCTGCTAATATCAAAGCTCTGTTTGTGTCTGAG
GAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATATGCCCCAGGC
TATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCCAATACTTGC
AGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTGGATGTCTGC
AAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTGAAGGAGAAA

>37494_37494_17_HP-CFB_HP_chr16_72093066_ENST00000569639_CFB_chr6_31918944_ENST00000425368_length(amino acids)=134AA_BP=
MFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG

--------------------------------------------------------------
>37494_37494_18_HP-CFB_HP_chr16_72093066_ENST00000569639_CFB_chr6_31918944_ENST00000456570_length(transcript)=948nt_BP=514nt
ACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGAC
TCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTAC
CAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGGTGGGTGCTGAGCACTTAAGAGAGCAGGC
AGGCGTCCAGCGGGGAACGTCCTAGAGGCACAGCCTTCCAGTGCGGCTTCCTCTGAGCACACAAGAGCCAGGAGGAGGGATGTGGGAGAA
CCGCAGCTGGCCAGGGAGAGACTTAAGCAGTTAGGTGATGACTCCCTAAGGGTCACCAAGGGTCTTGTTCATTAGGGCCTGAAGGGCACT
GGCTGAATCCATTGTCTACATCGCCCACAGATTAGGAGAGCCTGTGCATACAGAGAGCCTGCTAATATCAAAGCTCTGTTTGTGTCTGAG
GAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATATGCCCCAGGC
TATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCCAATACTTGC
AGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTGGATGTCTGC
AAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTGAAGGAGAAA

>37494_37494_18_HP-CFB_HP_chr16_72093066_ENST00000569639_CFB_chr6_31918944_ENST00000456570_length(amino acids)=134AA_BP=
MFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG

--------------------------------------------------------------
>37494_37494_19_HP-CFB_HP_chr16_72093066_ENST00000569639_CFB_chr6_31918944_ENST00000477310_length(transcript)=930nt_BP=514nt
ACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGAC
TCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTAC
CAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGGTGGGTGCTGAGCACTTAAGAGAGCAGGC
AGGCGTCCAGCGGGGAACGTCCTAGAGGCACAGCCTTCCAGTGCGGCTTCCTCTGAGCACACAAGAGCCAGGAGGAGGGATGTGGGAGAA
CCGCAGCTGGCCAGGGAGAGACTTAAGCAGTTAGGTGATGACTCCCTAAGGGTCACCAAGGGTCTTGTTCATTAGGGCCTGAAGGGCACT
GGCTGAATCCATTGTCTACATCGCCCACAGATTAGGAGAGCCTGTGCATACAGAGAGCCTGCTAATATCAAAGCTCTGTTTGTGTCTGAG
GAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATATGCCCCAGGC
TATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCCAATACTTGC
AGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTGGATGTCTGC
AAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTGAAGGAGAAA

>37494_37494_19_HP-CFB_HP_chr16_72093066_ENST00000569639_CFB_chr6_31918944_ENST00000477310_length(amino acids)=134AA_BP=
MFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG

--------------------------------------------------------------
>37494_37494_20_HP-CFB_HP_chr16_72093066_ENST00000569639_CFB_chr6_31918944_ENST00000556679_length(transcript)=948nt_BP=514nt
ACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGAC
TCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTAC
CAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGCAGGTGGGTGCTGAGCACTTAAGAGAGCAGGC
AGGCGTCCAGCGGGGAACGTCCTAGAGGCACAGCCTTCCAGTGCGGCTTCCTCTGAGCACACAAGAGCCAGGAGGAGGGATGTGGGAGAA
CCGCAGCTGGCCAGGGAGAGACTTAAGCAGTTAGGTGATGACTCCCTAAGGGTCACCAAGGGTCTTGTTCATTAGGGCCTGAAGGGCACT
GGCTGAATCCATTGTCTACATCGCCCACAGATTAGGAGAGCCTGTGCATACAGAGAGCCTGCTAATATCAAAGCTCTGTTTGTGTCTGAG
GAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATATGCCCCAGGC
TATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCCAATACTTGC
AGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTGGATGTCTGC
AAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTGAAGGAGAAA

>37494_37494_20_HP-CFB_HP_chr16_72093066_ENST00000569639_CFB_chr6_31918944_ENST00000556679_length(amino acids)=134AA_BP=
MFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG

--------------------------------------------------------------
>37494_37494_21_HP-CFB_HP_chr16_72093066_ENST00000570083_CFB_chr6_31918944_ENST00000425368_length(transcript)=742nt_BP=272nt
AGCATAAAAAGACCAGCAGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCT
CCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGC
ACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGC
AGATATCAAAGCTCTGTTTGTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTG
TGAGAGAGATGCTCAATATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGT
GAGTCCCTATGCTGACCCCAATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGT
AATCAGCTGGGGAGTAGTGGATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTT
TCAAGTGCTGCCCTGGCTGAAGGAGAAACTCCAAGATGAGGATTTGGGTTTTCTATAAGGGGTTTCCTGCTGGACAGGGGCGTGGGATTG

>37494_37494_21_HP-CFB_HP_chr16_72093066_ENST00000570083_CFB_chr6_31918944_ENST00000425368_length(amino acids)=222AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------
>37494_37494_22_HP-CFB_HP_chr16_72093066_ENST00000570083_CFB_chr6_31918944_ENST00000456570_length(transcript)=706nt_BP=272nt
AGCATAAAAAGACCAGCAGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCT
CCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGC
ACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGC
AGATATCAAAGCTCTGTTTGTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTG
TGAGAGAGATGCTCAATATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGT
GAGTCCCTATGCTGACCCCAATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGT
AATCAGCTGGGGAGTAGTGGATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTT

>37494_37494_22_HP-CFB_HP_chr16_72093066_ENST00000570083_CFB_chr6_31918944_ENST00000456570_length(amino acids)=222AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------
>37494_37494_23_HP-CFB_HP_chr16_72093066_ENST00000570083_CFB_chr6_31918944_ENST00000477310_length(transcript)=688nt_BP=272nt
AGCATAAAAAGACCAGCAGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCT
CCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGC
ACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGC
AGATATCAAAGCTCTGTTTGTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTG
TGAGAGAGATGCTCAATATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGT
GAGTCCCTATGCTGACCCCAATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGT
AATCAGCTGGGGAGTAGTGGATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTT

>37494_37494_23_HP-CFB_HP_chr16_72093066_ENST00000570083_CFB_chr6_31918944_ENST00000477310_length(amino acids)=223AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------
>37494_37494_24_HP-CFB_HP_chr16_72093066_ENST00000570083_CFB_chr6_31918944_ENST00000556679_length(transcript)=706nt_BP=272nt
AGCATAAAAAGACCAGCAGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCT
CCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGC
ACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGAACTTCCTGAATGTGAAGC
AGATATCAAAGCTCTGTTTGTGTCTGAGGAGGAGAAAAAGCTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTG
TGAGAGAGATGCTCAATATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGT
GAGTCCCTATGCTGACCCCAATACTTGCAGAGGTGATTCTGGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGT
AATCAGCTGGGGAGTAGTGGATGTCTGCAAAAACCAGAAGCGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTT

>37494_37494_24_HP-CFB_HP_chr16_72093066_ENST00000570083_CFB_chr6_31918944_ENST00000556679_length(amino acids)=222AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HP-CFB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	HP	chr16:72093066	chr6:31918944	ENST00000355906	+	1	7	318_323	0	407.0	CD163
Hgene	HP	chr16:72093066	chr6:31918944	ENST00000398131	+	1	5	318_323	0	348.0	CD163
Hgene	HP	chr16:72093066	chr6:31918944	ENST00000565574	+	1	5	318_323	0	348.0	CD163
Hgene	HP	chr16:72093066	chr6:31918944	ENST00000570083	+	1	5	318_323	0	348.0	CD163

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for HP-CFB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for HP-CFB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source