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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABHD12-KIF16B (FusionGDB2 ID:375)

Fusion Gene Summary for ABHD12-KIF16B

check button Fusion gene summary
Fusion gene informationFusion gene name: ABHD12-KIF16B
Fusion gene ID: 375
HgeneTgene
Gene symbol

ABHD12

KIF16B

Gene ID

26090

55614

Gene nameabhydrolase domain containing 12, lysophospholipasekinesin family member 16B
SynonymsABHD12A|BEM46L2|C20orf22|PHARC|dJ965G21.2|hABHD12C20orf23|KISC20ORF|SNX23
Cytomap

20p11.21

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionlysophosphatidylserine lipase ABHD122-arachidonoylglycerol hydrolase2-arachidonoylglycerol hydrolase ABHD12abhydrolase domain containing 12abhydrolase domain-containing protein 12monoacylglycerol lipase ABHD12oxidized phosphatidylserine lipase ABHD1kinesin-like protein KIF16Bkinesin motor proteinsorting nexin 23testis secretory sperm-binding protein Li 201a
Modification date2020031320200313
UniProtAcc

Q8N2K0

Q96L93

Ensembl transtripts involved in fusion geneENST00000339157, ENST00000376542, 
ENST00000481556, 		ENST00000355755, 
ENST00000378003, ENST00000408042, 
ENST00000354981, 
Fusion gene scores* DoF score11 X 8 X 6=5287 X 5 X 6=210
# samples 138
** MAII scorelog2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABHD12 [Title/Abstract] AND KIF16B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABHD12(25282855)-KIF16B(16509085), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABHD12

GO:0006660

phosphatidylserine catabolic process

30643283

HgeneABHD12

GO:0009395

phospholipid catabolic process

30237167

HgeneABHD12

GO:0046464

acylglycerol catabolic process

22969151

HgeneABHD12

GO:0046475

glycerophospholipid catabolic process

25290914

HgeneABHD12

GO:0052651

monoacylglycerol catabolic process

25290914|30237167


check buttonFusion gene breakpoints across ABHD12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIF16B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-7142-01AABHD12chr20

25282855

-KIF16Bchr20

16509085

-


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Fusion Gene ORF analysis for ABHD12-KIF16B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000339157ENST00000355755ABHD12chr20

25282855

-KIF16Bchr20

16509085

-
5CDS-5UTRENST00000339157ENST00000378003ABHD12chr20

25282855

-KIF16Bchr20

16509085

-
5CDS-5UTRENST00000339157ENST00000408042ABHD12chr20

25282855

-KIF16Bchr20

16509085

-
5CDS-5UTRENST00000376542ENST00000355755ABHD12chr20

25282855

-KIF16Bchr20

16509085

-
5CDS-5UTRENST00000376542ENST00000378003ABHD12chr20

25282855

-KIF16Bchr20

16509085

-
5CDS-5UTRENST00000376542ENST00000408042ABHD12chr20

25282855

-KIF16Bchr20

16509085

-
In-frameENST00000339157ENST00000354981ABHD12chr20

25282855

-KIF16Bchr20

16509085

-
In-frameENST00000376542ENST00000354981ABHD12chr20

25282855

-KIF16Bchr20

16509085

-
intron-3CDSENST00000481556ENST00000354981ABHD12chr20

25282855

-KIF16Bchr20

16509085

-
intron-5UTRENST00000481556ENST00000355755ABHD12chr20

25282855

-KIF16Bchr20

16509085

-
intron-5UTRENST00000481556ENST00000378003ABHD12chr20

25282855

-KIF16Bchr20

16509085

-
intron-5UTRENST00000481556ENST00000408042ABHD12chr20

25282855

-KIF16Bchr20

16509085

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376542ABHD12chr2025282855-ENST00000354981KIF16Bchr2016509085-6493143719953431714
ENST00000339157ABHD12chr2025282855-ENST00000354981KIF16Bchr2016509085-6486143019253361714

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376542ENST00000354981ABHD12chr2025282855-KIF16Bchr2016509085-0.0018413270.99815863
ENST00000339157ENST00000354981ABHD12chr2025282855-KIF16Bchr2016509085-0.00182530.99817467

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Fusion Genomic Features for ABHD12-KIF16B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABHD12-KIF16B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:25282855/chr20:16509085)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABHD12

Q8N2K0

KIF16B

Q96L93

FUNCTION: Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30720278, PubMed:30643283). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167). {ECO:0000250|UniProtKB:Q99LR1, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24027063, ECO:0000269|PubMed:25290914, ECO:0000269|PubMed:30237167, ECO:0000269|PubMed:30420694, ECO:0000269|PubMed:30643283, ECO:0000269|PubMed:30720278}.FUNCTION: Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABHD12chr20:25282855chr20:16509085ENST00000339157-121320_25385399.0Compositional biasNote=Poly-Ser
HgeneABHD12chr20:25282855chr20:16509085ENST00000339157-121326_29385399.0Compositional biasNote=Poly-Ala
HgeneABHD12chr20:25282855chr20:16509085ENST00000376542-121320_25385405.0Compositional biasNote=Poly-Ser
HgeneABHD12chr20:25282855chr20:16509085ENST00000376542-121326_29385405.0Compositional biasNote=Poly-Ala
HgeneABHD12chr20:25282855chr20:16509085ENST00000339157-12131_74385399.0Topological domainCytoplasmic
HgeneABHD12chr20:25282855chr20:16509085ENST00000376542-12131_74385405.0Topological domainCytoplasmic
HgeneABHD12chr20:25282855chr20:16509085ENST00000339157-121375_95385399.0TransmembraneHelical
HgeneABHD12chr20:25282855chr20:16509085ENST00000376542-121375_95385405.0TransmembraneHelical
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000354981026370_425151318.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000354981026595_882151318.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000354981026936_1087151318.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000355755025370_425151288.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000355755025595_882151288.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000355755025936_1087151288.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000408042023370_425151393.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000408042023595_882151393.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000408042023936_1087151393.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000354981026597_1070151318.0Compositional biasNote=Glu-rich
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000355755025597_1070151288.0Compositional biasNote=Glu-rich
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000408042023597_1070151393.0Compositional biasNote=Glu-rich
TgeneKIF16Bchr20:25282855chr20:16509085ENST000003549810261182_1296151318.0DomainPX
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000354981026478_529151318.0DomainNote=FHA
TgeneKIF16Bchr20:25282855chr20:16509085ENST000003557550251182_1296151288.0DomainPX
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000355755025478_529151288.0DomainNote=FHA
TgeneKIF16Bchr20:25282855chr20:16509085ENST000004080420231182_1296151393.0DomainPX
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000408042023478_529151393.0DomainNote=FHA
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000354981026102_109151318.0Nucleotide bindingATP
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000355755025102_109151288.0Nucleotide bindingATP
TgeneKIF16Bchr20:25282855chr20:16509085ENST00000408042023102_109151393.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABHD12chr20:25282855chr20:16509085ENST00000339157-121396_398385399.0Topological domainExtracellular
HgeneABHD12chr20:25282855chr20:16509085ENST00000376542-121396_398385405.0Topological domainExtracellular
TgeneKIF16Bchr20:25282855chr20:16509085ENST000003549810263_358151318.0DomainKinesin motor
TgeneKIF16Bchr20:25282855chr20:16509085ENST000003557550253_358151288.0DomainKinesin motor
TgeneKIF16Bchr20:25282855chr20:16509085ENST000004080420233_358151393.0DomainKinesin motor


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Fusion Gene Sequence for ABHD12-KIF16B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>375_375_1_ABHD12-KIF16B_ABHD12_chr20_25282855_ENST00000339157_KIF16B_chr20_16509085_ENST00000354981_length(transcript)=6486nt_BP=1430nt
ATGCTGGGCGCGCGCTCCTTGGAACTAGAGAGGAGGTGGCCGGGGCGGGGCCGGGGGAGGGGGGTAGGGCAGAGCCGGCGGGAGCCCGGC
GCTGATTGGCCGGCCTGGCTGGCGGGCCCCCGCCGCTGGTTCGTAGCCGGCGCAGCGGCCTGGGCTGGGATGTGAGGAGCGGCGGGTTCC
GGGCTCCGGGCTCTGGGTGGCGGCGGCTGTGAGCGGCGGCACTGCGGCGCAGGCCAGCGGGCGCCGTCGGCGGCTGGCCCTGTCGGCCGC
GGGATGAGGAAGCGGACCGAGCCCGTCGCCTTGGAGCATGAGCGCTGCGCCGCCGCGGGCTCGTCCTCCTCCGGCTCGGCCGCCGCGGCG
CTGGACGCCGACTGCCGCCTGAAGCAGAACCTACGCCTGACGGGCCCGGCGGCGGCTGAGCCGCGCTGCGCAGCCGACGCGGGAATGAAG
CGGGCGCTGGGCAGGCGAAAGGGCGTGTGGTTGCGCCTGAGGAAGATACTTTTCTGTGTTTTGGGGTTGTACATTGCCATTCCATTTCTC
ATCAAACTATGTCCTGGAATACAGGCCAAACTGATTTTCTTGAATTTCGTAAGAGTTCCCTATTTCATTGATTTGAAAAAACCACAGGAT
CAAGGTTTGAATCACACGTGTAACTACTACCTGCAGCCAGAGGAAGACGTGACCATTGGAGTCTGGCACACCGTCCCTGCAGTCTGGTGG
AAGAACGCCCAAGGCAAAGACCAGATGTGGTATGAGGATGCCTTGGCTTCCAGCCACCCTATCATTCTGTACCTGCATGGGAACGCAGGT
ACCAGAGGAGGCGACCACCGCGTGGAGCTTTACAAGGTGCTGAGTTCCCTTGGTTACCATGTGGTCACCTTTGACTACAGAGGTTGGGGT
GACTCAGTGGGAACGCCATCTGAGCGGGGCATGACCTATGACGCACTCCACGTTTTTGACTGGATCAAAGCAAGAAGTGGTGACAACCCC
GTGTACATCTGGGGCCACTCTCTGGGCACTGGCGTGGCGACAAATCTGGTGCGGCGCCTCTGTGAGCGAGAGACGCCTCCAGATGCCCTT
ATATTGGAATCTCCATTCACTAATATCCGCGAAGAAGCTAAGAGCCATCCATTTTCAGTGATATATCGATACTTCCCTGGGTTTGACTGG
TTCTTCCTTGATCCTATTACAAGTAGTGGAATTAAATTTGCAAATGATGAAAACGTGAAGCACATCTCCTGTCCCCTGCTCATCCTGCAC
GCTGAGGACGACCCGGTGGTGCCCTTCCAGCTTGGCAGAAAGCTCTATAGCATCGCCGCACCAGCTCGAAGCTTCCGAGATTTCAAAGTT
CAGTTTGTGCCCTTTCATTCAGACCTTGGCTACAGGCACAAATACATTTACAAGAGCCCTGAGCTGCCACGGATACTGAGGGAAAAGGAC
TTGGAGGCCAAGTTCATTATTCAGATGGAGAAAAGCAAAACGACAATCACAAACTTAAAGATACCAGAAGGAGGCACTGGGGACTCAGGA
AGAGAACGGACCAAGACCTTCACCTATGACTTTTCTTTTTATTCTGCTGATACAAAAAGCCCAGATTACGTTTCACAAGAAATGGTTTTC
AAAACCCTCGGCACAGATGTCGTGAAGTCTGCATTTGAAGGTTATAATGCTTGTGTCTTTGCATATGGGCAAACTGGATCTGGAAAGTCA
TACACTATGATGGGAAATTCTGGAGATTCTGGCTTAATACCTCGGATCTGTGAAGGACTCTTCAGTCGGATAAATGAAACCACCAGATGG
GATGAAGCTTCTTTTCGAACTGAAGTCAGCTACTTAGAAATTTATAACGAACGTGTGAGAGATCTACTTCGGCGGAAGTCATCTAAAACC
TTCAATTTGAGAGTCCGTGAGCATCCCAAAGAAGGCCCTTATGTTGAGGATTTATCCAAACATTTAGTACAGAATTATGGTGACGTAGAA
GAACTTATGGATGCGGGCAATATCAACCGGACCACCGCAGCGACTGGGATGAACGACGTCAGTAGCAGGTCTCATGCCATCTTCACCATC
AAGTTCACTCAGGCTAAATTTGATTCTGAAATGCCATGTGAAACCGTCAGTAAGATCCACTTGGTTGATCTTGCCGGAAGTGAGCGTGCA
GATGCCACCGGAGCCACCGGGGTTAGGCTAAAGGAAGGGGGAAATATTAACAAGTCCCTCGTGACTCTGGGGAACGTCATTTCTGCCTTA
GCTGATTTATCTCAGGATGCTGCAAATACTCTTGCAAAGAAGAAGCAAGTTTTCGTGCCTTACAGGGATTCTGTGTTGACTTGGTTGTTA
AAAGATAGCCTTGGAGGAAACTCTAAAACTATCATGATTGCCACCATTTCACCTGCTGATGTCAATTATGGAGAAACCCTAAGTACTCTT
CGCTATGCAAATAGAGCCAAAAACATCATCAACAAGCCTACCATTAATGAGGATGCCAACGTCAAACTTATCCGTGAGCTGCGAGCTGAA
ATAGCCAGACTGAAAACGCTGCTTGCTCAAGGGAATCAGATTGCCCTCTTAGACTCCCCCACAGCTTTAAGTATGGAGGAAAAACTTCAG
CAGAATGAAGCAAGAGTTCAAGAATTGACCAAGGAATGGACAAATAAGTGGAATGAAACCCAAAATATTTTGAAAGAACAAACTCTAGCC
CTCAGGAAAGAAGGGATTGGAGTTGTTTTGGATTCTGAACTGCCTCATTTGATTGGCATCGATGATGACCTTTTGAGTACTGGAATCATC
TTATATCATTTAAAGGAAGGTCAGACATACGTTGGTAGAGACGATGCTTCCACGGAGCAAGATATTGTTCTTCATGGCCTTGACTTGGAG
AGTGAGCATTGCATCTTTGAAAATATCGGGGGGACAGTGACTCTGATACCCCTGAGTGGGTCCCAGTGCTCTGTGAATGGTGTTCAGATC
GTGGAGGCCACACATCTAAATCAAGGTGCTGTGATTCTCTTGGGAAGAACCAATATGTTTCGCTTTAACCATCCAAAGGAAGCCGCCAAG
CTCAGGGAGAAGAGGAAGAGTGGCCTTCTGTCCTCCTTCAGCTTGTCCATGACCGACCTCTCGAAGTCCCGTGAGAACCTGTCTGCAGTC
ATGTTGTATAACCCCGGACTTGAATTTGAGAGGCAACAGCGTGAAGAACTTGAAAAATTAGAAAGTAAAAGGAAACTCATAGAAGAAATG
GAGGAAAAGCAGAAATCAGACAAGGCTGAACTGGAGCGGATGCAGCAGGAGGTGGAGACCCAGCGCAAGGAGACAGAAATCGTGCAGCTC
CAGATTCGCAAGCAGGAGGAGAGCCTCAAACGCCGCAGCTTCCACATCGAGAACAAGCTAAAGGATTTACTTGCGGAGAAGGAAAAATTT
GAAGAGGAGAGGCTGAGGGAACAGCAGGAAATCGAGCTGCAGAAGAAGAGACAAGAAGAAGAGACCTTTCTCCGCGTCCAAGAAGAACTC
CAACGACTCAAAGAACTCAACAACAACGAGAAGGCTGAGAAGTTTCAGATATTTCAAGAACTGGACCAGCTCCAAAAGGAAAAAGATGAA
CAGTATGCCAAGCTTGAACTGGAAAAAAAGAGACTAGAGGAGCAGGAGAAGGAGCAGGTCATGCTCGTGGCCCATCTGGAAGAGCAGCTC
CGAGAGAAGCAGGAGATGATCCAGCTCCTGCGGCGTGGGGAGGTACAGTGGGTGGAAGAGGAGAAGAGGGACCTGGAAGGCATTCGGGAA
TCCCTCCTGCGGGTGAAGGAGGCTCGTGCCGGAGGGGATGAAGATGGCGAGGAGTTAGAAAAGGCTCAACTGCGTTTCTTCGAATTCAAG
AGAAGGCAGCTTGTCAAGCTAGTGAACTTGGAGAAGGACCTGGTTCAGCAGAAAGACATCCTGAAAAAAGAAGTCCAAGAAGAACAGGAG
ATCCTAGAGTGTTTAAAATGTGAACATGACAAAGAATCTAGATTGTTGGAAAAACATGATGAGAGTGTCACAGATGTCACGGAAGTGCCT
CAAGATTTCGAGAAAATAAAGCCAGTGGAGTACAGGCTGCAATATAAAGAACGCCAGCTACAGTACCTCCTGCAGAATCACTTGCCAACT
CTGTTGGAAGAAAAGCAGAGAGCATTTGAAATTCTTGACAGAGGCCCTCTCAGCTTAGACAACACTCTTTATCAAGTAGAAAAGGAAATG
GAAGAAAAAGAAGAACAGCTTGCACAGTACCAGGCCAATGCAAACCAGCTGCAAAAGCTCCAAGCCACCTTTGAATTCACTGCCAACATT
GCACGTCAGGAGGAAAAAGTGAGGAAAAAGGAAAAGGAGATTTTGGAGTCCAGAGAGAAGCAGCAGAGAGAGGCGCTGGAGCGGGCCCTG
GCCAGGCTGGAGAGGAGACATTCTGCGCTGCAGAGGCACTCCACCCTGGGCATGGAGATTGAAGAGCAGAGGCAGAAACTTGCCAGTCTG
AACAGTGGCAGCAGAGAGCAGTCAGGGCTCCAGGCTAGCCTGGAGGCTGAGCAGGAAGCCCTGGAGAAGGACCAGGAGAGGTTAGAATAT
GAAATCCAGCAGCTGAAACAGAAGATTTATGAGGTCGATGGTGTTCAAAAAGATCATCATGGGACCCTGGAAGGGAAGGTGGCTTCTTCC
AGCTTGCCAGTCAGTGCTGAAAAATCACACCTGGTTCCCCTCATGGATGCCAGGATCAATGCTTACATTGAAGAAGAAGTCCAAAGACGC
CTTCAGGATTTGCATCGTGTGATTAGTGAAGGCTGCAGTACATCTGCAGACACGATGAAGGATAATGAGAAACTTCACAATGGCACCATT
CAACGTAAACTAAAATATGAGCGGATGGTTTCTCGCTCTTTGGGCGCAAATCCAGATGACCTGAAGGACCCAATTAAAATTAGTATCCCA
CGCTACGTCCTCTGCGGGCAAGGAAAGGATGCACACTTCGAGTTTGAGGTCAAGATTACTGTCCTAGATGAGACATGGACTGTATTCAGG
CGTTACAGTCGTTTTCGAGAAATGCATAAAACATTGAAGTTAAAGTATGCAGAGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTT
GGAAATAAGGATGAACGTGTGATTGCTGAGAGACGAAGTCACTTAGAGAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCAGTCCGCA
ACATCTCCCCTCCACATCAACAAAGTGGGACTGACTCTCTCGAAACATACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTT
GACTACAGCAGCCACGGGACGGGGTAGAGCCAGGGGTGATGGAGGAACCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCCGATGCAG
GGCAGCTCCCCCATGCGAGGATCCGGGTCTGCCTCCTCCTGCTGAAGACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGTTTCCATA
CCTAGTGCCTGAGTTTGGGGATGGGATGCTCTGCCTGCTGATGTGGCCCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGAACGTGGC
CTTTTCCCACAGTGCTTCCTTCTCACTGCGCAGCAAAGTTCGTCCCCTGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTTCCCTGAG
CCCAGCCAGCCTGGGACCTCCCAAAGTGGGTGGCTTACCAGACCACCCTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAAAATATAC
TCGTATTTTTTATATTTCTTCCATGTGGCTGGCTATATTCCAAGAAAAGCATTTTAAATTATTTCATTGTATTTTTTTCTTTTTTTCCCT
CATTTGAATCAGAACTTTTATATAAAACCCAAACACTGATGTTTACACAGAATTTCATATTCTGCAAAAGGGATTTTTTGATCCAATCAT
GACTGTAGTCTTCCATGCTTGACAAATTGGATGTAGACAACATTACTTAAAACTTCTATAAATCCCTACAATTAGGATATTTATTTAACC
TTGAATATTCAAGAACATTCTCCCAAATCTAAATGGCTACTGTGCATTCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCAAAGCTAA
ATGCATATTTTTAAGTATTATTCACATTTTTTGTTACAGAATCTATTGGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTTTATTAAT
GATACCTTAAATTACTCAGGACTTAATGTAGCATTGCACTTCTGTGTACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAATGTGAGTG
GAAAAAATATGTATGTGGTATATACTCAAATGTATATAATTCTATCTATAGATTTATATATGTATACATTCTGTACAGTAGTTCCATCAA
AATATGTAATAATTCACACCAATTTTATTAAATGTATTTGCTTTTTCAAAATTTAAATTGAGCTGCTATCAATATTAAATGAAGTTATGG

>375_375_1_ABHD12-KIF16B_ABHD12_chr20_25282855_ENST00000339157_KIF16B_chr20_16509085_ENST00000354981_length(amino acids)=1714AA_BP=412
MGGGGCERRHCGAGQRAPSAAGPVGRGMRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALG
RRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQ
GKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIW
GHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDD
PVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERT
KTFTYDFSFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRICEGLFSRINETTRWDEAS
FRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQ
AKFDSEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTWLLKDSL
GGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEEKLQQNEA
RVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHC
IFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYN
PGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEER
LREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQ
EMIQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQEEQEILEC
LKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKE
EQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGS
REQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDL
HRVISEGCSTSADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISIPRYVLCGQGKDAHFEFEVKITVLDETWTVFRRYSR
FREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAERRSHLEKYLRDFFSVMLQSATSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSS

--------------------------------------------------------------
>375_375_2_ABHD12-KIF16B_ABHD12_chr20_25282855_ENST00000376542_KIF16B_chr20_16509085_ENST00000354981_length(transcript)=6493nt_BP=1437nt
GCCAGGGATGCTGGGCGCGCGCTCCTTGGAACTAGAGAGGAGGTGGCCGGGGCGGGGCCGGGGGAGGGGGGTAGGGCAGAGCCGGCGGGA
GCCCGGCGCTGATTGGCCGGCCTGGCTGGCGGGCCCCCGCCGCTGGTTCGTAGCCGGCGCAGCGGCCTGGGCTGGGATGTGAGGAGCGGC
GGGTTCCGGGCTCCGGGCTCTGGGTGGCGGCGGCTGTGAGCGGCGGCACTGCGGCGCAGGCCAGCGGGCGCCGTCGGCGGCTGGCCCTGT
CGGCCGCGGGATGAGGAAGCGGACCGAGCCCGTCGCCTTGGAGCATGAGCGCTGCGCCGCCGCGGGCTCGTCCTCCTCCGGCTCGGCCGC
CGCGGCGCTGGACGCCGACTGCCGCCTGAAGCAGAACCTACGCCTGACGGGCCCGGCGGCGGCTGAGCCGCGCTGCGCAGCCGACGCGGG
AATGAAGCGGGCGCTGGGCAGGCGAAAGGGCGTGTGGTTGCGCCTGAGGAAGATACTTTTCTGTGTTTTGGGGTTGTACATTGCCATTCC
ATTTCTCATCAAACTATGTCCTGGAATACAGGCCAAACTGATTTTCTTGAATTTCGTAAGAGTTCCCTATTTCATTGATTTGAAAAAACC
ACAGGATCAAGGTTTGAATCACACGTGTAACTACTACCTGCAGCCAGAGGAAGACGTGACCATTGGAGTCTGGCACACCGTCCCTGCAGT
CTGGTGGAAGAACGCCCAAGGCAAAGACCAGATGTGGTATGAGGATGCCTTGGCTTCCAGCCACCCTATCATTCTGTACCTGCATGGGAA
CGCAGGTACCAGAGGAGGCGACCACCGCGTGGAGCTTTACAAGGTGCTGAGTTCCCTTGGTTACCATGTGGTCACCTTTGACTACAGAGG
TTGGGGTGACTCAGTGGGAACGCCATCTGAGCGGGGCATGACCTATGACGCACTCCACGTTTTTGACTGGATCAAAGCAAGAAGTGGTGA
CAACCCCGTGTACATCTGGGGCCACTCTCTGGGCACTGGCGTGGCGACAAATCTGGTGCGGCGCCTCTGTGAGCGAGAGACGCCTCCAGA
TGCCCTTATATTGGAATCTCCATTCACTAATATCCGCGAAGAAGCTAAGAGCCATCCATTTTCAGTGATATATCGATACTTCCCTGGGTT
TGACTGGTTCTTCCTTGATCCTATTACAAGTAGTGGAATTAAATTTGCAAATGATGAAAACGTGAAGCACATCTCCTGTCCCCTGCTCAT
CCTGCACGCTGAGGACGACCCGGTGGTGCCCTTCCAGCTTGGCAGAAAGCTCTATAGCATCGCCGCACCAGCTCGAAGCTTCCGAGATTT
CAAAGTTCAGTTTGTGCCCTTTCATTCAGACCTTGGCTACAGGCACAAATACATTTACAAGAGCCCTGAGCTGCCACGGATACTGAGGGA
AAAGGACTTGGAGGCCAAGTTCATTATTCAGATGGAGAAAAGCAAAACGACAATCACAAACTTAAAGATACCAGAAGGAGGCACTGGGGA
CTCAGGAAGAGAACGGACCAAGACCTTCACCTATGACTTTTCTTTTTATTCTGCTGATACAAAAAGCCCAGATTACGTTTCACAAGAAAT
GGTTTTCAAAACCCTCGGCACAGATGTCGTGAAGTCTGCATTTGAAGGTTATAATGCTTGTGTCTTTGCATATGGGCAAACTGGATCTGG
AAAGTCATACACTATGATGGGAAATTCTGGAGATTCTGGCTTAATACCTCGGATCTGTGAAGGACTCTTCAGTCGGATAAATGAAACCAC
CAGATGGGATGAAGCTTCTTTTCGAACTGAAGTCAGCTACTTAGAAATTTATAACGAACGTGTGAGAGATCTACTTCGGCGGAAGTCATC
TAAAACCTTCAATTTGAGAGTCCGTGAGCATCCCAAAGAAGGCCCTTATGTTGAGGATTTATCCAAACATTTAGTACAGAATTATGGTGA
CGTAGAAGAACTTATGGATGCGGGCAATATCAACCGGACCACCGCAGCGACTGGGATGAACGACGTCAGTAGCAGGTCTCATGCCATCTT
CACCATCAAGTTCACTCAGGCTAAATTTGATTCTGAAATGCCATGTGAAACCGTCAGTAAGATCCACTTGGTTGATCTTGCCGGAAGTGA
GCGTGCAGATGCCACCGGAGCCACCGGGGTTAGGCTAAAGGAAGGGGGAAATATTAACAAGTCCCTCGTGACTCTGGGGAACGTCATTTC
TGCCTTAGCTGATTTATCTCAGGATGCTGCAAATACTCTTGCAAAGAAGAAGCAAGTTTTCGTGCCTTACAGGGATTCTGTGTTGACTTG
GTTGTTAAAAGATAGCCTTGGAGGAAACTCTAAAACTATCATGATTGCCACCATTTCACCTGCTGATGTCAATTATGGAGAAACCCTAAG
TACTCTTCGCTATGCAAATAGAGCCAAAAACATCATCAACAAGCCTACCATTAATGAGGATGCCAACGTCAAACTTATCCGTGAGCTGCG
AGCTGAAATAGCCAGACTGAAAACGCTGCTTGCTCAAGGGAATCAGATTGCCCTCTTAGACTCCCCCACAGCTTTAAGTATGGAGGAAAA
ACTTCAGCAGAATGAAGCAAGAGTTCAAGAATTGACCAAGGAATGGACAAATAAGTGGAATGAAACCCAAAATATTTTGAAAGAACAAAC
TCTAGCCCTCAGGAAAGAAGGGATTGGAGTTGTTTTGGATTCTGAACTGCCTCATTTGATTGGCATCGATGATGACCTTTTGAGTACTGG
AATCATCTTATATCATTTAAAGGAAGGTCAGACATACGTTGGTAGAGACGATGCTTCCACGGAGCAAGATATTGTTCTTCATGGCCTTGA
CTTGGAGAGTGAGCATTGCATCTTTGAAAATATCGGGGGGACAGTGACTCTGATACCCCTGAGTGGGTCCCAGTGCTCTGTGAATGGTGT
TCAGATCGTGGAGGCCACACATCTAAATCAAGGTGCTGTGATTCTCTTGGGAAGAACCAATATGTTTCGCTTTAACCATCCAAAGGAAGC
CGCCAAGCTCAGGGAGAAGAGGAAGAGTGGCCTTCTGTCCTCCTTCAGCTTGTCCATGACCGACCTCTCGAAGTCCCGTGAGAACCTGTC
TGCAGTCATGTTGTATAACCCCGGACTTGAATTTGAGAGGCAACAGCGTGAAGAACTTGAAAAATTAGAAAGTAAAAGGAAACTCATAGA
AGAAATGGAGGAAAAGCAGAAATCAGACAAGGCTGAACTGGAGCGGATGCAGCAGGAGGTGGAGACCCAGCGCAAGGAGACAGAAATCGT
GCAGCTCCAGATTCGCAAGCAGGAGGAGAGCCTCAAACGCCGCAGCTTCCACATCGAGAACAAGCTAAAGGATTTACTTGCGGAGAAGGA
AAAATTTGAAGAGGAGAGGCTGAGGGAACAGCAGGAAATCGAGCTGCAGAAGAAGAGACAAGAAGAAGAGACCTTTCTCCGCGTCCAAGA
AGAACTCCAACGACTCAAAGAACTCAACAACAACGAGAAGGCTGAGAAGTTTCAGATATTTCAAGAACTGGACCAGCTCCAAAAGGAAAA
AGATGAACAGTATGCCAAGCTTGAACTGGAAAAAAAGAGACTAGAGGAGCAGGAGAAGGAGCAGGTCATGCTCGTGGCCCATCTGGAAGA
GCAGCTCCGAGAGAAGCAGGAGATGATCCAGCTCCTGCGGCGTGGGGAGGTACAGTGGGTGGAAGAGGAGAAGAGGGACCTGGAAGGCAT
TCGGGAATCCCTCCTGCGGGTGAAGGAGGCTCGTGCCGGAGGGGATGAAGATGGCGAGGAGTTAGAAAAGGCTCAACTGCGTTTCTTCGA
ATTCAAGAGAAGGCAGCTTGTCAAGCTAGTGAACTTGGAGAAGGACCTGGTTCAGCAGAAAGACATCCTGAAAAAAGAAGTCCAAGAAGA
ACAGGAGATCCTAGAGTGTTTAAAATGTGAACATGACAAAGAATCTAGATTGTTGGAAAAACATGATGAGAGTGTCACAGATGTCACGGA
AGTGCCTCAAGATTTCGAGAAAATAAAGCCAGTGGAGTACAGGCTGCAATATAAAGAACGCCAGCTACAGTACCTCCTGCAGAATCACTT
GCCAACTCTGTTGGAAGAAAAGCAGAGAGCATTTGAAATTCTTGACAGAGGCCCTCTCAGCTTAGACAACACTCTTTATCAAGTAGAAAA
GGAAATGGAAGAAAAAGAAGAACAGCTTGCACAGTACCAGGCCAATGCAAACCAGCTGCAAAAGCTCCAAGCCACCTTTGAATTCACTGC
CAACATTGCACGTCAGGAGGAAAAAGTGAGGAAAAAGGAAAAGGAGATTTTGGAGTCCAGAGAGAAGCAGCAGAGAGAGGCGCTGGAGCG
GGCCCTGGCCAGGCTGGAGAGGAGACATTCTGCGCTGCAGAGGCACTCCACCCTGGGCATGGAGATTGAAGAGCAGAGGCAGAAACTTGC
CAGTCTGAACAGTGGCAGCAGAGAGCAGTCAGGGCTCCAGGCTAGCCTGGAGGCTGAGCAGGAAGCCCTGGAGAAGGACCAGGAGAGGTT
AGAATATGAAATCCAGCAGCTGAAACAGAAGATTTATGAGGTCGATGGTGTTCAAAAAGATCATCATGGGACCCTGGAAGGGAAGGTGGC
TTCTTCCAGCTTGCCAGTCAGTGCTGAAAAATCACACCTGGTTCCCCTCATGGATGCCAGGATCAATGCTTACATTGAAGAAGAAGTCCA
AAGACGCCTTCAGGATTTGCATCGTGTGATTAGTGAAGGCTGCAGTACATCTGCAGACACGATGAAGGATAATGAGAAACTTCACAATGG
CACCATTCAACGTAAACTAAAATATGAGCGGATGGTTTCTCGCTCTTTGGGCGCAAATCCAGATGACCTGAAGGACCCAATTAAAATTAG
TATCCCACGCTACGTCCTCTGCGGGCAAGGAAAGGATGCACACTTCGAGTTTGAGGTCAAGATTACTGTCCTAGATGAGACATGGACTGT
ATTCAGGCGTTACAGTCGTTTTCGAGAAATGCATAAAACATTGAAGTTAAAGTATGCAGAGCTTGCTGCCCTTGAATTTCCTCCAAAGAA
ACTATTTGGAAATAAGGATGAACGTGTGATTGCTGAGAGACGAAGTCACTTAGAGAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCA
GTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACTGACTCTCTCGAAACATACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGG
AGTCTTTGACTACAGCAGCCACGGGACGGGGTAGAGCCAGGGGTGATGGAGGAACCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCC
GATGCAGGGCAGCTCCCCCATGCGAGGATCCGGGTCTGCCTCCTCCTGCTGAAGACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGT
TTCCATACCTAGTGCCTGAGTTTGGGGATGGGATGCTCTGCCTGCTGATGTGGCCCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGA
ACGTGGCCTTTTCCCACAGTGCTTCCTTCTCACTGCGCAGCAAAGTTCGTCCCCTGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTT
CCCTGAGCCCAGCCAGCCTGGGACCTCCCAAAGTGGGTGGCTTACCAGACCACCCTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAA
AATATACTCGTATTTTTTATATTTCTTCCATGTGGCTGGCTATATTCCAAGAAAAGCATTTTAAATTATTTCATTGTATTTTTTTCTTTT
TTTCCCTCATTTGAATCAGAACTTTTATATAAAACCCAAACACTGATGTTTACACAGAATTTCATATTCTGCAAAAGGGATTTTTTGATC
CAATCATGACTGTAGTCTTCCATGCTTGACAAATTGGATGTAGACAACATTACTTAAAACTTCTATAAATCCCTACAATTAGGATATTTA
TTTAACCTTGAATATTCAAGAACATTCTCCCAAATCTAAATGGCTACTGTGCATTCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCA
AAGCTAAATGCATATTTTTAAGTATTATTCACATTTTTTGTTACAGAATCTATTGGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTT
TATTAATGATACCTTAAATTACTCAGGACTTAATGTAGCATTGCACTTCTGTGTACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAAT
GTGAGTGGAAAAAATATGTATGTGGTATATACTCAAATGTATATAATTCTATCTATAGATTTATATATGTATACATTCTGTACAGTAGTT
CCATCAAAATATGTAATAATTCACACCAATTTTATTAAATGTATTTGCTTTTTCAAAATTTAAATTGAGCTGCTATCAATATTAAATGAA

>375_375_2_ABHD12-KIF16B_ABHD12_chr20_25282855_ENST00000376542_KIF16B_chr20_16509085_ENST00000354981_length(amino acids)=1714AA_BP=412
MGGGGCERRHCGAGQRAPSAAGPVGRGMRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALG
RRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQ
GKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIW
GHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDD
PVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERT
KTFTYDFSFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRICEGLFSRINETTRWDEAS
FRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQ
AKFDSEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTWLLKDSL
GGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEEKLQQNEA
RVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHC
IFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYN
PGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEER
LREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQ
EMIQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQEEQEILEC
LKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKE
EQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGS
REQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDL
HRVISEGCSTSADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISIPRYVLCGQGKDAHFEFEVKITVLDETWTVFRRYSR
FREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAERRSHLEKYLRDFFSVMLQSATSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABHD12-KIF16B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABHD12-KIF16B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABHD12-KIF16B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource