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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HPGD-GUCY1A3 (FusionGDB2 ID:37501)

Fusion Gene Summary for HPGD-GUCY1A3

Fusion gene summary

Fusion gene information	Fusion gene name: HPGD-GUCY1A3
	Fusion gene ID: 37501
		Hgene	Tgene
	Gene symbol	HPGD	GUCY1A3
	Gene ID	3248	2982
	Gene name	15-hydroxyprostaglandin dehydrogenase	guanylate cyclase 1 soluble subunit alpha 1
	Synonyms	15-PGDH\|PGDH\|PGDH1\|PHOAR1\|SDR36C1	GC-SA3\|GUC1A3\|GUCA3\|GUCSA3\|GUCY1A3\|MYMY6
	Cytomap	4q34.1	4q32.1
	Type of gene	protein-coding	protein-coding
	Description	15-hydroxyprostaglandin dehydrogenase [NAD(+)]15-hydroxyprostaglandin dehydrogenase (NAD(+))NAD+-dependent 15-hydroxyprostaglandin dehydrogenasehydroxyprostaglandin dehydrogenase 15-(NAD)prostaglandin dehydrogenase 1short chain dehydrogenase/reductas	guanylate cyclase soluble subunit alpha-1GC-S-alpha-1GCS-alpha-3guanylate cyclase 1, soluble, alpha 3soluble guanylate cyclase large subunit
	Modification date	20200313	20200313
	UniProtAcc	P15428	.
	Ensembl transtripts involved in fusion gene	ENST00000296521, ENST00000296522, ENST00000422112, ENST00000504433, ENST00000542498, ENST00000510901, ENST00000541923,	ENST00000455639, ENST00000515602, ENST00000296518, ENST00000393832, ENST00000513574, ENST00000506455, ENST00000511108, ENST00000511507,
Fusion gene scores	* DoF score	3 X 4 X 2=24	1 X 2 X 1=2
	# samples	4	2
	** MAII score	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(2/2*10)=3.32192809488736
Context	PubMed: HPGD [Title/Abstract] AND GUCY1A3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HPGD(175443095)-GUCY1A3(156629388), # samples:3
Anticipated loss of major functional domain due to fusion event.	HPGD-GUCY1A3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. HPGD-GUCY1A3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. HPGD-GUCY1A3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HPGD	GO:0006693	prostaglandin metabolic process	16828555\|21072165
Hgene	HPGD	GO:0007179	transforming growth factor beta receptor signaling pathway	15574495
Hgene	HPGD	GO:0007565	female pregnancy	15531523
Hgene	HPGD	GO:0007567	parturition	15531523
Hgene	HPGD	GO:0045786	negative regulation of cell cycle	15574495
Tgene	GUCY1A3	GO:0006182	cGMP biosynthetic process	23505436

Fusion gene breakpoints across HPGD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GUCY1A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-K4-A3WU-01B	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
ChimerDB4	BLCA	TCGA-K4-A3WU	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+

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Fusion Gene ORF analysis for HPGD-GUCY1A3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000296521	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000296521	ENST00000455639	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-3UTR	ENST00000296521	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000296521	ENST00000515602	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-3UTR	ENST00000296522	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000296522	ENST00000455639	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-3UTR	ENST00000296522	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000296522	ENST00000515602	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-3UTR	ENST00000422112	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000422112	ENST00000455639	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-3UTR	ENST00000422112	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000422112	ENST00000515602	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-3UTR	ENST00000504433	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000504433	ENST00000455639	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-3UTR	ENST00000504433	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000504433	ENST00000515602	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-3UTR	ENST00000542498	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000542498	ENST00000455639	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-3UTR	ENST00000542498	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000542498	ENST00000515602	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000296521	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000296521	ENST00000296518	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000296521	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000296521	ENST00000393832	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000296521	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000296521	ENST00000513574	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000296522	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000296522	ENST00000296518	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000296522	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000296522	ENST00000393832	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000296522	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000296522	ENST00000513574	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000422112	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000422112	ENST00000296518	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000422112	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000422112	ENST00000393832	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000422112	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000422112	ENST00000513574	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000504433	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000504433	ENST00000296518	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000504433	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000504433	ENST00000393832	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000504433	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000504433	ENST00000513574	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000542498	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000542498	ENST00000296518	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000542498	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000542498	ENST00000393832	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5CDS-5UTR	ENST00000542498	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000542498	ENST00000513574	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-3CDS	ENST00000510901	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3CDS	ENST00000510901	ENST00000506455	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-3CDS	ENST00000510901	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3CDS	ENST00000510901	ENST00000511108	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-3CDS	ENST00000510901	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3CDS	ENST00000510901	ENST00000511507	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-3CDS	ENST00000541923	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3CDS	ENST00000541923	ENST00000506455	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-3CDS	ENST00000541923	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3CDS	ENST00000541923	ENST00000511108	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-3CDS	ENST00000541923	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3CDS	ENST00000541923	ENST00000511507	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-3UTR	ENST00000510901	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3UTR	ENST00000510901	ENST00000455639	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-3UTR	ENST00000510901	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3UTR	ENST00000510901	ENST00000515602	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-3UTR	ENST00000541923	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3UTR	ENST00000541923	ENST00000455639	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-3UTR	ENST00000541923	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3UTR	ENST00000541923	ENST00000515602	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-5UTR	ENST00000510901	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-5UTR	ENST00000510901	ENST00000296518	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-5UTR	ENST00000510901	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-5UTR	ENST00000510901	ENST00000393832	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-5UTR	ENST00000510901	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-5UTR	ENST00000510901	ENST00000513574	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-5UTR	ENST00000541923	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-5UTR	ENST00000541923	ENST00000296518	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-5UTR	ENST00000541923	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-5UTR	ENST00000541923	ENST00000393832	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
5UTR-5UTR	ENST00000541923	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-5UTR	ENST00000541923	ENST00000513574	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000296521	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000296521	ENST00000506455	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000296521	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000296521	ENST00000511108	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000296521	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000296521	ENST00000511507	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000296522	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000296522	ENST00000506455	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000296522	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000296522	ENST00000511108	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000296522	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000296522	ENST00000511507	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000422112	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000422112	ENST00000506455	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000422112	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000422112	ENST00000511108	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000422112	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000422112	ENST00000511507	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000504433	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000504433	ENST00000506455	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000504433	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000504433	ENST00000511108	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000504433	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000504433	ENST00000511507	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000542498	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000542498	ENST00000506455	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000542498	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000542498	ENST00000511108	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+
Frame-shift	ENST00000542498	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000542498	ENST00000511507	HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for HPGD-GUCY1A3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+	0.10139711	0.8986029
HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+	0.10139711	0.8986029
HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+	0.10139711	0.8986029
HPGD	chr4	175443094	-	GUCY1A3	chr4	156629387	+	0.10139711	0.8986029

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HPGD-GUCY1A3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:175443095/:156629388)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HPGD P15428	.
FUNCTION: Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites (Probable). Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels (PubMed:15574495, PubMed:16828555, PubMed:8086429). Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (PubMed:10837478). Converts 11(R)-HETE to 11-oxo-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (ETE) (PubMed:21916491). Has hydroxylated docosahexaenoic acid metabolites as substrates (PubMed:25586183). Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions (PubMed:16757471, PubMed:22844113). {ECO:0000269\|PubMed:10837478, ECO:0000269\|PubMed:15574495, ECO:0000269\|PubMed:16757471, ECO:0000269\|PubMed:16828555, ECO:0000269\|PubMed:21916491, ECO:0000269\|PubMed:22844113, ECO:0000269\|PubMed:25586183, ECO:0000269\|PubMed:8086429, ECO:0000305\|PubMed:25586183}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HPGD-GUCY1A3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HPGD-GUCY1A3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HPGD-GUCY1A3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HPGD-GUCY1A3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source