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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HP-RBP4 (FusionGDB2 ID:37514)

Fusion Gene Summary for HP-RBP4

check button Fusion gene summary
Fusion gene informationFusion gene name: HP-RBP4
Fusion gene ID: 37514
HgeneTgene
Gene symbol

HP

RBP4

Gene ID

10395

5950

Gene nameDLC1 Rho GTPase activating proteinretinol binding protein 4
SynonymsARHGAP7|HP|STARD12|p122-RhoGAPMCOPCB10|RDCCAS
Cytomap

8p22

10q23.33

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer variaretinol-binding protein 4PRBPRBPplasma retinol-binding proteinretinol binding protein 4, plasmaretinol-binding protein 4, interstitial
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000355906, ENST00000357763, 
ENST00000398131, ENST00000565574, 
ENST00000562526, ENST00000569639, 
ENST00000570083, 		ENST00000371464, 
ENST00000371467, ENST00000371469, 
Fusion gene scores* DoF score9 X 11 X 3=2978 X 5 X 4=160
# samples 108
** MAII scorelog2(10/297*10)=-1.57046293102604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HP [Title/Abstract] AND RBP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHP(72090530)-RBP4(95353792), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHP

GO:0006915

apoptotic process

17292327

HgeneHP

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17888903

HgeneHP

GO:0008285

negative regulation of cell proliferation

12545165|17932950

HgeneHP

GO:0030336

negative regulation of cell migration

17932950|19158340

HgeneHP

GO:0035307

positive regulation of protein dephosphorylation

17292327

HgeneHP

GO:0051497

negative regulation of stress fiber assembly

17932950

HgeneHP

GO:0051895

negative regulation of focal adhesion assembly

19158340

HgeneHP

GO:1900119

positive regulation of execution phase of apoptosis

17888903

TgeneRBP4

GO:0030277

maintenance of gastrointestinal epithelium

10944490

TgeneRBP4

GO:0032526

response to retinoic acid

571335

TgeneRBP4

GO:0042593

glucose homeostasis

17003346


check buttonFusion gene breakpoints across HP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BC-A10T-11AHPchr16

72090530

+RBP4chr10

95353792

-


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Fusion Gene ORF analysis for HP-RBP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000355906ENST00000371464HPchr16

72090530

+RBP4chr10

95353792

-
In-frameENST00000355906ENST00000371467HPchr16

72090530

+RBP4chr10

95353792

-
In-frameENST00000355906ENST00000371469HPchr16

72090530

+RBP4chr10

95353792

-
In-frameENST00000357763ENST00000371464HPchr16

72090530

+RBP4chr10

95353792

-
In-frameENST00000357763ENST00000371467HPchr16

72090530

+RBP4chr10

95353792

-
In-frameENST00000357763ENST00000371469HPchr16

72090530

+RBP4chr10

95353792

-
In-frameENST00000398131ENST00000371464HPchr16

72090530

+RBP4chr10

95353792

-
In-frameENST00000398131ENST00000371467HPchr16

72090530

+RBP4chr10

95353792

-
In-frameENST00000398131ENST00000371469HPchr16

72090530

+RBP4chr10

95353792

-
In-frameENST00000565574ENST00000371464HPchr16

72090530

+RBP4chr10

95353792

-
In-frameENST00000565574ENST00000371467HPchr16

72090530

+RBP4chr10

95353792

-
In-frameENST00000565574ENST00000371469HPchr16

72090530

+RBP4chr10

95353792

-
intron-3CDSENST00000562526ENST00000371464HPchr16

72090530

+RBP4chr10

95353792

-
intron-3CDSENST00000562526ENST00000371467HPchr16

72090530

+RBP4chr10

95353792

-
intron-3CDSENST00000562526ENST00000371469HPchr16

72090530

+RBP4chr10

95353792

-
intron-3CDSENST00000569639ENST00000371464HPchr16

72090530

+RBP4chr10

95353792

-
intron-3CDSENST00000569639ENST00000371467HPchr16

72090530

+RBP4chr10

95353792

-
intron-3CDSENST00000569639ENST00000371469HPchr16

72090530

+RBP4chr10

95353792

-
intron-3CDSENST00000570083ENST00000371464HPchr16

72090530

+RBP4chr10

95353792

-
intron-3CDSENST00000570083ENST00000371467HPchr16

72090530

+RBP4chr10

95353792

-
intron-3CDSENST00000570083ENST00000371469HPchr16

72090530

+RBP4chr10

95353792

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355906HPchr1672090530+ENST00000371464RBP4chr1095353792-88724816498160
ENST00000355906HPchr1672090530+ENST00000371467RBP4chr1095353792-88724816498160
ENST00000355906HPchr1672090530+ENST00000371469RBP4chr1095353792-68524816498160
ENST00000398131HPchr1672090530+ENST00000371464RBP4chr1095353792-8732342484160
ENST00000398131HPchr1672090530+ENST00000371467RBP4chr1095353792-8732342484160
ENST00000398131HPchr1672090530+ENST00000371469RBP4chr1095353792-6712342484160
ENST00000357763HPchr1672090530+ENST00000371464RBP4chr1095353792-85621727467146
ENST00000357763HPchr1672090530+ENST00000371467RBP4chr1095353792-85621727467146
ENST00000357763HPchr1672090530+ENST00000371469RBP4chr1095353792-65421727467146
ENST00000565574HPchr1672090530+ENST00000371464RBP4chr1095353792-85321424464146
ENST00000565574HPchr1672090530+ENST00000371467RBP4chr1095353792-85321424464146
ENST00000565574HPchr1672090530+ENST00000371469RBP4chr1095353792-65121424464146

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355906ENST00000371464HPchr1672090530+RBP4chr1095353792-0.0090677150.9909322
ENST00000355906ENST00000371467HPchr1672090530+RBP4chr1095353792-0.0090677150.9909322
ENST00000355906ENST00000371469HPchr1672090530+RBP4chr1095353792-0.0055393640.9944607
ENST00000398131ENST00000371464HPchr1672090530+RBP4chr1095353792-0.0093654270.9906345
ENST00000398131ENST00000371467HPchr1672090530+RBP4chr1095353792-0.0093654270.9906345
ENST00000398131ENST00000371469HPchr1672090530+RBP4chr1095353792-0.0049698660.99503016
ENST00000357763ENST00000371464HPchr1672090530+RBP4chr1095353792-0.0162024680.9837975
ENST00000357763ENST00000371467HPchr1672090530+RBP4chr1095353792-0.0162024680.9837975
ENST00000357763ENST00000371469HPchr1672090530+RBP4chr1095353792-0.007085350.9929147
ENST00000565574ENST00000371464HPchr1672090530+RBP4chr1095353792-0.0139830470.9860169
ENST00000565574ENST00000371467HPchr1672090530+RBP4chr1095353792-0.0139830470.9860169
ENST00000565574ENST00000371469HPchr1672090530+RBP4chr1095353792-0.0066935160.99330646

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Fusion Genomic Features for HP-RBP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HP-RBP4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:72090530/chr10:95353792)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHPchr16:72090530chr10:95353792ENST00000355906+37162_40463407.0DomainPeptidase S1
HgeneHPchr16:72090530chr10:95353792ENST00000355906+3731_8863407.0DomainSushi 1
HgeneHPchr16:72090530chr10:95353792ENST00000355906+3790_14763407.0DomainSushi 2
HgeneHPchr16:72090530chr10:95353792ENST00000398131+35162_40463348.0DomainPeptidase S1
HgeneHPchr16:72090530chr10:95353792ENST00000398131+3531_8863348.0DomainSushi 1
HgeneHPchr16:72090530chr10:95353792ENST00000398131+3590_14763348.0DomainSushi 2
HgeneHPchr16:72090530chr10:95353792ENST00000565574+35162_40463348.0DomainPeptidase S1
HgeneHPchr16:72090530chr10:95353792ENST00000565574+3531_8863348.0DomainSushi 1
HgeneHPchr16:72090530chr10:95353792ENST00000565574+3590_14763348.0DomainSushi 2
HgeneHPchr16:72090530chr10:95353792ENST00000570083+15162_4040348.0DomainPeptidase S1
HgeneHPchr16:72090530chr10:95353792ENST00000570083+1531_880348.0DomainSushi 1
HgeneHPchr16:72090530chr10:95353792ENST00000570083+1590_1470348.0DomainSushi 2


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Fusion Gene Sequence for HP-RBP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37514_37514_1_HP-RBP4_HP_chr16_72090530_ENST00000355906_RBP4_chr10_95353792_ENST00000371464_length(transcript)=887nt_BP=248nt
ATAAAAAGACCAGCAGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCT
GCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACA
TGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGATGATGACCACTGGATCGTCGA
CACAGACTACGACACGTATGCCGTGCAGTACTCCTGCCGCCTCCTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTC
CCGGGACCCCAACGGCCTGCCCCCAGAAGCGCAGAAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCCAGGCAGTACAGGCTGAT
CGTCCACAACGGTTACTGCGATGGCAGATCAGAAAGAAACCTTTTGTAGCAATATCAAGAATCTAGTTTCATCTGAGAACTTCTGATTAG
CTCTCAGTCTTCAGCTCTATTTATCTTAGGAGTTTAATTTGCCCTTCTCTCCCCATCTTCCCTCAGTTCCCATAAAACCTTCATTACACA
TAAAGATACACGTGGGGGTCAGTGAATCTGCTTGCCTTTCCTGAAAGTTTCTGGGGCTTAAGATTCCAGACTCTGATTCATTAAACTATA
GTCACCCGTGTCCTGTGATTTTAGTTTTCATTTGTGTTTATGTCTGTGCTGCAGACGGATGGGTGGGGTGCGCTTCTTTATACCAGGAGC

>37514_37514_1_HP-RBP4_HP_chr16_72090530_ENST00000355906_RBP4_chr10_95353792_ENST00000371464_length(amino acids)=160AA_BP=70
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDDDDHWIVDTDYDT

--------------------------------------------------------------
>37514_37514_2_HP-RBP4_HP_chr16_72090530_ENST00000355906_RBP4_chr10_95353792_ENST00000371467_length(transcript)=887nt_BP=248nt
ATAAAAAGACCAGCAGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCT
GCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACA
TGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGATGATGACCACTGGATCGTCGA
CACAGACTACGACACGTATGCCGTGCAGTACTCCTGCCGCCTCCTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTC
CCGGGACCCCAACGGCCTGCCCCCAGAAGCGCAGAAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCCAGGCAGTACAGGCTGAT
CGTCCACAACGGTTACTGCGATGGCAGATCAGAAAGAAACCTTTTGTAGCAATATCAAGAATCTAGTTTCATCTGAGAACTTCTGATTAG
CTCTCAGTCTTCAGCTCTATTTATCTTAGGAGTTTAATTTGCCCTTCTCTCCCCATCTTCCCTCAGTTCCCATAAAACCTTCATTACACA
TAAAGATACACGTGGGGGTCAGTGAATCTGCTTGCCTTTCCTGAAAGTTTCTGGGGCTTAAGATTCCAGACTCTGATTCATTAAACTATA
GTCACCCGTGTCCTGTGATTTTAGTTTTCATTTGTGTTTATGTCTGTGCTGCAGACGGATGGGTGGGGTGCGCTTCTTTATACCAGGAGC

>37514_37514_2_HP-RBP4_HP_chr16_72090530_ENST00000355906_RBP4_chr10_95353792_ENST00000371467_length(amino acids)=160AA_BP=70
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDDDDHWIVDTDYDT

--------------------------------------------------------------
>37514_37514_3_HP-RBP4_HP_chr16_72090530_ENST00000355906_RBP4_chr10_95353792_ENST00000371469_length(transcript)=685nt_BP=248nt
ATAAAAAGACCAGCAGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCT
GCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACA
TGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGATGATGACCACTGGATCGTCGA
CACAGACTACGACACGTATGCCGTGCAGTACTCCTGCCGCCTCCTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTC
CCGGGACCCCAACGGCCTGCCCCCAGAAGCGCAGAAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCCAGGCAGTACAGGCTGAT
CGTCCACAACGGTTACTGCGATGGCAGATCAGAAAGAAACCTTTTGTAGCAATATCAAGAATCTAGTTTCATCTGAGAACTTCTGATTAG
CTCTCAGTCTTCAGCTCTATTTATCTTAGGAGTTTAATTTGCCCTTCTCTCCCCATCTTCCCTCAGTTCCCATAAAACCTTCATTACACA

>37514_37514_3_HP-RBP4_HP_chr16_72090530_ENST00000355906_RBP4_chr10_95353792_ENST00000371469_length(amino acids)=160AA_BP=70
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDDDDHWIVDTDYDT

--------------------------------------------------------------
>37514_37514_4_HP-RBP4_HP_chr16_72090530_ENST00000357763_RBP4_chr10_95353792_ENST00000371464_length(transcript)=856nt_BP=217nt
GCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCA
GGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAG
TGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGATGATGACCACTGGATCGTCGACACAGACTACGACACGTATGCCGTGCAGTAC
TCCTGCCGCCTCCTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTCCCGGGACCCCAACGGCCTGCCCCCAGAAGCG
CAGAAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCCAGGCAGTACAGGCTGATCGTCCACAACGGTTACTGCGATGGCAGATCA
GAAAGAAACCTTTTGTAGCAATATCAAGAATCTAGTTTCATCTGAGAACTTCTGATTAGCTCTCAGTCTTCAGCTCTATTTATCTTAGGA
GTTTAATTTGCCCTTCTCTCCCCATCTTCCCTCAGTTCCCATAAAACCTTCATTACACATAAAGATACACGTGGGGGTCAGTGAATCTGC
TTGCCTTTCCTGAAAGTTTCTGGGGCTTAAGATTCCAGACTCTGATTCATTAAACTATAGTCACCCGTGTCCTGTGATTTTAGTTTTCAT
TTGTGTTTATGTCTGTGCTGCAGACGGATGGGTGGGGTGCGCTTCTTTATACCAGGAGCACGTGGCTCTTTCTGACCTTTGGCCTGTTCT

>37514_37514_4_HP-RBP4_HP_chr16_72090530_ENST00000357763_RBP4_chr10_95353792_ENST00000371464_length(amino acids)=146AA_BP=56
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDDDDHWIVDTDYDTYAVQYSCRLLNLDG

--------------------------------------------------------------
>37514_37514_5_HP-RBP4_HP_chr16_72090530_ENST00000357763_RBP4_chr10_95353792_ENST00000371467_length(transcript)=856nt_BP=217nt
GCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCA
GGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAG
TGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGATGATGACCACTGGATCGTCGACACAGACTACGACACGTATGCCGTGCAGTAC
TCCTGCCGCCTCCTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTCCCGGGACCCCAACGGCCTGCCCCCAGAAGCG
CAGAAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCCAGGCAGTACAGGCTGATCGTCCACAACGGTTACTGCGATGGCAGATCA
GAAAGAAACCTTTTGTAGCAATATCAAGAATCTAGTTTCATCTGAGAACTTCTGATTAGCTCTCAGTCTTCAGCTCTATTTATCTTAGGA
GTTTAATTTGCCCTTCTCTCCCCATCTTCCCTCAGTTCCCATAAAACCTTCATTACACATAAAGATACACGTGGGGGTCAGTGAATCTGC
TTGCCTTTCCTGAAAGTTTCTGGGGCTTAAGATTCCAGACTCTGATTCATTAAACTATAGTCACCCGTGTCCTGTGATTTTAGTTTTCAT
TTGTGTTTATGTCTGTGCTGCAGACGGATGGGTGGGGTGCGCTTCTTTATACCAGGAGCACGTGGCTCTTTCTGACCTTTGGCCTGTTCT

>37514_37514_5_HP-RBP4_HP_chr16_72090530_ENST00000357763_RBP4_chr10_95353792_ENST00000371467_length(amino acids)=146AA_BP=56
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDDDDHWIVDTDYDTYAVQYSCRLLNLDG

--------------------------------------------------------------
>37514_37514_6_HP-RBP4_HP_chr16_72090530_ENST00000357763_RBP4_chr10_95353792_ENST00000371469_length(transcript)=654nt_BP=217nt
GCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCA
GGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAG
TGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGATGATGACCACTGGATCGTCGACACAGACTACGACACGTATGCCGTGCAGTAC
TCCTGCCGCCTCCTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTCCCGGGACCCCAACGGCCTGCCCCCAGAAGCG
CAGAAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCCAGGCAGTACAGGCTGATCGTCCACAACGGTTACTGCGATGGCAGATCA
GAAAGAAACCTTTTGTAGCAATATCAAGAATCTAGTTTCATCTGAGAACTTCTGATTAGCTCTCAGTCTTCAGCTCTATTTATCTTAGGA
GTTTAATTTGCCCTTCTCTCCCCATCTTCCCTCAGTTCCCATAAAACCTTCATTACACATAAAGATACACGTGGGGGTCAGTGAATCTGC

>37514_37514_6_HP-RBP4_HP_chr16_72090530_ENST00000357763_RBP4_chr10_95353792_ENST00000371469_length(amino acids)=146AA_BP=56
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDDDDHWIVDTDYDTYAVQYSCRLLNLDG

--------------------------------------------------------------
>37514_37514_7_HP-RBP4_HP_chr16_72090530_ENST00000398131_RBP4_chr10_95353792_ENST00000371464_length(transcript)=873nt_BP=234nt
AGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGC
TTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGC
ACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGATGATGACCACTGGATCGTCGACACAGACTACGACA
CGTATGCCGTGCAGTACTCCTGCCGCCTCCTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTCCCGGGACCCCAACG
GCCTGCCCCCAGAAGCGCAGAAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCCAGGCAGTACAGGCTGATCGTCCACAACGGTT
ACTGCGATGGCAGATCAGAAAGAAACCTTTTGTAGCAATATCAAGAATCTAGTTTCATCTGAGAACTTCTGATTAGCTCTCAGTCTTCAG
CTCTATTTATCTTAGGAGTTTAATTTGCCCTTCTCTCCCCATCTTCCCTCAGTTCCCATAAAACCTTCATTACACATAAAGATACACGTG
GGGGTCAGTGAATCTGCTTGCCTTTCCTGAAAGTTTCTGGGGCTTAAGATTCCAGACTCTGATTCATTAAACTATAGTCACCCGTGTCCT
GTGATTTTAGTTTTCATTTGTGTTTATGTCTGTGCTGCAGACGGATGGGTGGGGTGCGCTTCTTTATACCAGGAGCACGTGGCTCTTTCT

>37514_37514_7_HP-RBP4_HP_chr16_72090530_ENST00000398131_RBP4_chr10_95353792_ENST00000371464_length(amino acids)=160AA_BP=70
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDDDDHWIVDTDYDT

--------------------------------------------------------------
>37514_37514_8_HP-RBP4_HP_chr16_72090530_ENST00000398131_RBP4_chr10_95353792_ENST00000371467_length(transcript)=873nt_BP=234nt
AGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGC
TTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGC
ACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGATGATGACCACTGGATCGTCGACACAGACTACGACA
CGTATGCCGTGCAGTACTCCTGCCGCCTCCTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTCCCGGGACCCCAACG
GCCTGCCCCCAGAAGCGCAGAAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCCAGGCAGTACAGGCTGATCGTCCACAACGGTT
ACTGCGATGGCAGATCAGAAAGAAACCTTTTGTAGCAATATCAAGAATCTAGTTTCATCTGAGAACTTCTGATTAGCTCTCAGTCTTCAG
CTCTATTTATCTTAGGAGTTTAATTTGCCCTTCTCTCCCCATCTTCCCTCAGTTCCCATAAAACCTTCATTACACATAAAGATACACGTG
GGGGTCAGTGAATCTGCTTGCCTTTCCTGAAAGTTTCTGGGGCTTAAGATTCCAGACTCTGATTCATTAAACTATAGTCACCCGTGTCCT
GTGATTTTAGTTTTCATTTGTGTTTATGTCTGTGCTGCAGACGGATGGGTGGGGTGCGCTTCTTTATACCAGGAGCACGTGGCTCTTTCT

>37514_37514_8_HP-RBP4_HP_chr16_72090530_ENST00000398131_RBP4_chr10_95353792_ENST00000371467_length(amino acids)=160AA_BP=70
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDDDDHWIVDTDYDT

--------------------------------------------------------------
>37514_37514_9_HP-RBP4_HP_chr16_72090530_ENST00000398131_RBP4_chr10_95353792_ENST00000371469_length(transcript)=671nt_BP=234nt
AGATGCCCCACAGCACTGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGC
TTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGC
ACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGATGATGACCACTGGATCGTCGACACAGACTACGACA
CGTATGCCGTGCAGTACTCCTGCCGCCTCCTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTCCCGGGACCCCAACG
GCCTGCCCCCAGAAGCGCAGAAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCCAGGCAGTACAGGCTGATCGTCCACAACGGTT
ACTGCGATGGCAGATCAGAAAGAAACCTTTTGTAGCAATATCAAGAATCTAGTTTCATCTGAGAACTTCTGATTAGCTCTCAGTCTTCAG
CTCTATTTATCTTAGGAGTTTAATTTGCCCTTCTCTCCCCATCTTCCCTCAGTTCCCATAAAACCTTCATTACACATAAAGATACACGTG

>37514_37514_9_HP-RBP4_HP_chr16_72090530_ENST00000398131_RBP4_chr10_95353792_ENST00000371469_length(amino acids)=160AA_BP=70
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDDDDHWIVDTDYDT

--------------------------------------------------------------
>37514_37514_10_HP-RBP4_HP_chr16_72090530_ENST00000565574_RBP4_chr10_95353792_ENST00000371464_length(transcript)=853nt_BP=214nt
CTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGC
AATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGT
AAGAACTACTACAAACTGCGCACAGAAGGAGATGATGATGACCACTGGATCGTCGACACAGACTACGACACGTATGCCGTGCAGTACTCC
TGCCGCCTCCTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTCCCGGGACCCCAACGGCCTGCCCCCAGAAGCGCAG
AAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCCAGGCAGTACAGGCTGATCGTCCACAACGGTTACTGCGATGGCAGATCAGAA
AGAAACCTTTTGTAGCAATATCAAGAATCTAGTTTCATCTGAGAACTTCTGATTAGCTCTCAGTCTTCAGCTCTATTTATCTTAGGAGTT
TAATTTGCCCTTCTCTCCCCATCTTCCCTCAGTTCCCATAAAACCTTCATTACACATAAAGATACACGTGGGGGTCAGTGAATCTGCTTG
CCTTTCCTGAAAGTTTCTGGGGCTTAAGATTCCAGACTCTGATTCATTAAACTATAGTCACCCGTGTCCTGTGATTTTAGTTTTCATTTG
TGTTTATGTCTGTGCTGCAGACGGATGGGTGGGGTGCGCTTCTTTATACCAGGAGCACGTGGCTCTTTCTGACCTTTGGCCTGTTCTAGT

>37514_37514_10_HP-RBP4_HP_chr16_72090530_ENST00000565574_RBP4_chr10_95353792_ENST00000371464_length(amino acids)=146AA_BP=56
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDDDDHWIVDTDYDTYAVQYSCRLLNLDG

--------------------------------------------------------------
>37514_37514_11_HP-RBP4_HP_chr16_72090530_ENST00000565574_RBP4_chr10_95353792_ENST00000371467_length(transcript)=853nt_BP=214nt
CTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGC
AATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGT
AAGAACTACTACAAACTGCGCACAGAAGGAGATGATGATGACCACTGGATCGTCGACACAGACTACGACACGTATGCCGTGCAGTACTCC
TGCCGCCTCCTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTCCCGGGACCCCAACGGCCTGCCCCCAGAAGCGCAG
AAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCCAGGCAGTACAGGCTGATCGTCCACAACGGTTACTGCGATGGCAGATCAGAA
AGAAACCTTTTGTAGCAATATCAAGAATCTAGTTTCATCTGAGAACTTCTGATTAGCTCTCAGTCTTCAGCTCTATTTATCTTAGGAGTT
TAATTTGCCCTTCTCTCCCCATCTTCCCTCAGTTCCCATAAAACCTTCATTACACATAAAGATACACGTGGGGGTCAGTGAATCTGCTTG
CCTTTCCTGAAAGTTTCTGGGGCTTAAGATTCCAGACTCTGATTCATTAAACTATAGTCACCCGTGTCCTGTGATTTTAGTTTTCATTTG
TGTTTATGTCTGTGCTGCAGACGGATGGGTGGGGTGCGCTTCTTTATACCAGGAGCACGTGGCTCTTTCTGACCTTTGGCCTGTTCTAGT

>37514_37514_11_HP-RBP4_HP_chr16_72090530_ENST00000565574_RBP4_chr10_95353792_ENST00000371467_length(amino acids)=146AA_BP=56
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDDDDHWIVDTDYDTYAVQYSCRLLNLDG

--------------------------------------------------------------
>37514_37514_12_HP-RBP4_HP_chr16_72090530_ENST00000565574_RBP4_chr10_95353792_ENST00000371469_length(transcript)=651nt_BP=214nt
CTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGC
AATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGT
AAGAACTACTACAAACTGCGCACAGAAGGAGATGATGATGACCACTGGATCGTCGACACAGACTACGACACGTATGCCGTGCAGTACTCC
TGCCGCCTCCTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTCCCGGGACCCCAACGGCCTGCCCCCAGAAGCGCAG
AAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCCAGGCAGTACAGGCTGATCGTCCACAACGGTTACTGCGATGGCAGATCAGAA
AGAAACCTTTTGTAGCAATATCAAGAATCTAGTTTCATCTGAGAACTTCTGATTAGCTCTCAGTCTTCAGCTCTATTTATCTTAGGAGTT
TAATTTGCCCTTCTCTCCCCATCTTCCCTCAGTTCCCATAAAACCTTCATTACACATAAAGATACACGTGGGGGTCAGTGAATCTGCTTG

>37514_37514_12_HP-RBP4_HP_chr16_72090530_ENST00000565574_RBP4_chr10_95353792_ENST00000371469_length(amino acids)=146AA_BP=56
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDDDDHWIVDTDYDTYAVQYSCRLLNLDG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HP-RBP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHPchr16:72090530chr10:95353792ENST00000355906+37318_32363.333333333333336407.0CD163
HgeneHPchr16:72090530chr10:95353792ENST00000398131+35318_32363.333333333333336348.0CD163
HgeneHPchr16:72090530chr10:95353792ENST00000565574+35318_32363.333333333333336348.0CD163
HgeneHPchr16:72090530chr10:95353792ENST00000570083+15318_3230348.0CD163


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HP-RBP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HP-RBP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource