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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HPSE2-CWF19L1 (FusionGDB2 ID:37548)

Fusion Gene Summary for HPSE2-CWF19L1

check button Fusion gene summary
Fusion gene informationFusion gene name: HPSE2-CWF19L1
Fusion gene ID: 37548
HgeneTgene
Gene symbol

HPSE2

CWF19L1

Gene ID

60495

55280

Gene nameheparanase 2 (inactive)CWF19 like cell cycle control factor 1
SynonymsHPA2|HPR2|UFS|UFS1C19L1|SCAR17|hDrn1
Cytomap

10q24.2

10q24.31

Type of geneprotein-codingprotein-coding
Descriptioninactive heparanase-2heparanase 3heparanase-like proteinCWF19-like protein 1CWF19 like 1, cell cycle controlCWF19-like 1 cell cycle controlhuman Dbr1 associated ribonuclease 1
Modification date2020031320200313
UniProtAcc

Q8WWQ2

Q69YN2

Ensembl transtripts involved in fusion geneENST00000370546, ENST00000370549, 
ENST00000370552, ENST00000404542, 
ENST00000370379, ENST00000478047, 
ENST00000354105, 
Fusion gene scores* DoF score7 X 7 X 3=1474 X 4 X 4=64
# samples 74
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HPSE2 [Title/Abstract] AND CWF19L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHPSE2(100903995)-CWF19L1(102003534), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HPSE2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CWF19L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-FN-7833-01AHPSE2chr10

100903995

-CWF19L1chr10

102003534

-


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Fusion Gene ORF analysis for HPSE2-CWF19L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000370546ENST00000370379HPSE2chr10

100903995

-CWF19L1chr10

102003534

-
5CDS-intronENST00000370546ENST00000478047HPSE2chr10

100903995

-CWF19L1chr10

102003534

-
5CDS-intronENST00000370549ENST00000370379HPSE2chr10

100903995

-CWF19L1chr10

102003534

-
5CDS-intronENST00000370549ENST00000478047HPSE2chr10

100903995

-CWF19L1chr10

102003534

-
5CDS-intronENST00000370552ENST00000370379HPSE2chr10

100903995

-CWF19L1chr10

102003534

-
5CDS-intronENST00000370552ENST00000478047HPSE2chr10

100903995

-CWF19L1chr10

102003534

-
In-frameENST00000370546ENST00000354105HPSE2chr10

100903995

-CWF19L1chr10

102003534

-
In-frameENST00000370549ENST00000354105HPSE2chr10

100903995

-CWF19L1chr10

102003534

-
In-frameENST00000370552ENST00000354105HPSE2chr10

100903995

-CWF19L1chr10

102003534

-
intron-3CDSENST00000404542ENST00000354105HPSE2chr10

100903995

-CWF19L1chr10

102003534

-
intron-intronENST00000404542ENST00000370379HPSE2chr10

100903995

-CWF19L1chr10

102003534

-
intron-intronENST00000404542ENST00000478047HPSE2chr10

100903995

-CWF19L1chr10

102003534

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000370549HPSE2chr10100903995-ENST00000354105CWF19L1chr10102003534-2252670601322420
ENST00000370552HPSE2chr10100903995-ENST00000354105CWF19L1chr10102003534-2252670601322420
ENST00000370546HPSE2chr10100903995-ENST00000354105CWF19L1chr10102003534-219261001262420

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370549ENST00000354105HPSE2chr10100903995-CWF19L1chr10102003534-0.001482440.9985176
ENST00000370552ENST00000354105HPSE2chr10100903995-CWF19L1chr10102003534-0.001482440.9985176
ENST00000370546ENST00000354105HPSE2chr10100903995-CWF19L1chr10102003534-0.0015012630.9984988

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Fusion Genomic Features for HPSE2-CWF19L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HPSE2-CWF19L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:100903995/chr10:102003534)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HPSE2

Q8WWQ2

CWF19L1

Q69YN2

FUNCTION: Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). {ECO:0000269|PubMed:20576607}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HPSE2-CWF19L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37548_37548_1_HPSE2-CWF19L1_HPSE2_chr10_100903995_ENST00000370546_CWF19L1_chr10_102003534_ENST00000354105_length(transcript)=2192nt_BP=610nt
ATGAGGGTGCTTTGTGCCTTCCCTGAAGCCATGCCCTCCAGCAACTCCCGCCCCCCCGCGTGCCTAGCCCCGGGGGCTCTCTACTTGGCT
CTGTTGCTCCATCTCTCCCTTTCCTCCCAGGCTGGAGACAGGAGACCCTTGCCTGTAGACAGAGCTGCAGGTTTGAAGGAAAAGACCCTG
ATTCTACTTGATGTGAGCACCAAGAACCCAGTCAGGACAGTCAATGAGAACTTCCTCTCTCTGCAGCTGGATCCGTCCATCATTCATGAT
GGCTGGCTCGATTTCCTAAGCTCCAAGCGCTTGGTGACCCTGGCCCGGGGACTTTCGCCCGCCTTTCTGCGCTTCGGGGGCAAAAGGACC
GACTTCCTGCAGTTCCAGAACCTGAGGAACCCGGCGAAAAGCCGCGGGGGCCCGGGCCCGGATTACTATCTCAAAAACTATGAGGATGAC
ATTGTTCGAAGTGATGTTGCCTTAGATAAACAGAAAGGCTGCAAGATTGCCCAGCACCCTGATGTTATGCTGGAGCTCCAAAGGGAGAAG
GCAGCTCAGATGCATCTGGTTCTTCTAAAGGAGCAATTCTCCAATACTTACAGTAATCTCATATTAACAGCTCAGCCTCCAGGACCCTGC
TGGTTTTGCCTTGCTAGCCCTGAAGTGGAAAAACATTTGGTGGTCAACATCGGCACACATTGCTACCTTGCCCTGGCCAAAGGAGGCTTA
TCTGATGACCATGTCCTCATCCTGCCTATTGGACACTACCAGTCAGTGGTGGAGCTTTCAGCAGAGGTGGTAGAAGAGGTGGAGAAGTAT
AAGGCCACTCTGAGACGGTTCTTTAAGAGTCGAGGGAAATGGTGTGTTGTATTTGAGAGAAATTATAAGAGCCATCACCTCCAGCTACAG
GTCATTCCTGTCCCAATCAGCTGCTCTACTACTGATGACATTAAAGATGCCTTCATTACCCAGGCACAGGAGCAGCAGATAGAGCTGTTG
GAAATCCCAGAGCACTCTGACATCAAGCAGATTGCACAGCCAGGAGCAGCATATTTTTATGTTGAACTTGACACAGGAGAAAAGCTTTTC
CACAGAATTAAAAAGAATTTTCCTTTGCAGTTTGGAAGGGAGGTCCTGGCCAGTGAAGCCATCCTTAATGTTCCTGATAAGTCTGACTGG
AGGCAGTGTCAGATCAGCAAGGAAGACGAGGAGACCCTGGCTCGCCGCTTCCGGAAAGACTTTGAGCCCTATGACTTTACTCTGGATGAC
TAAAACAAAGGGAAGAACTTTTTATGAACTCCACAGGAAGTAGTAAAGCTTTTTTTTTTTTTTAATTAAAAGAATTTTTTTTGAGACAAA
GTCTCGCTCTGTCACCCAAGCAGGATTGCAGTGGCATAACTGTGGCTCACTGTAGCCTCAACCTCCTGGGCTCTAGAGTTCCTCCCACCT
CAGCCTCATGAGTAGCTGGGACCACAGGCGCATGCTACCATGCCTGGCAAACTTTTTTGATTTTTTATAGAGACAGGAGGGTCTCCCTGT
GTTGCCCAGGCTGGTCTGTAATGCCTAGGCTCAAGGGATCCTCTGCCTTGGCTTCTTAACCTGCTGGGATTACAAGCATGAGACACCATT
CCTGGCCTAGAAGCCTATTTTTAAAGAAACTACAATCTCCCATGGGGACTGTTTCCCTGCCTCTTTTGTGCAGTCCCATGGAACTTGCCT
ACAGCAAGAGGCCTAAGATTGAATCTTTTTGGGGAAAAGTCATTCTAGGATGAAAATCCTATGTTAAGGCCGGGCGCAGTGGCTCACGCC
TGTAATCCCAGTACTTTGGGAAGCCGAGGCAGGTGGATCACCTGAGGTGAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGT
CTTTACTAAAGCTACAAAAATTAGCTGGGCGTGGTGCCAGGCACTTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGA
GCCTGGGAGGTGGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCACTCCAGCCTGGGTGACAGTGAAACTCCATCTCAAAAATAAAAGAA
TAAAAGTATGTCTGTCATCCAGCTCCTATGTCTGTTATCCAGCTCCAAGTACAGCTTGTGTATATCAACATTTTCAAAAACCTTTAAACT

>37548_37548_1_HPSE2-CWF19L1_HPSE2_chr10_100903995_ENST00000370546_CWF19L1_chr10_102003534_ENST00000354105_length(amino acids)=420AA_BP=203
MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTLILLDVSTKNPVRTVNENFLSLQLDPSIIHD
GWLDFLSSKRLVTLARGLSPAFLRFGGKRTDFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
AAQMHLVLLKEQFSNTYSNLILTAQPPGPCWFCLASPEVEKHLVVNIGTHCYLALAKGGLSDDHVLILPIGHYQSVVELSAEVVEEVEKY
KATLRRFFKSRGKWCVVFERNYKSHHLQLQVIPVPISCSTTDDIKDAFITQAQEQQIELLEIPEHSDIKQIAQPGAAYFYVELDTGEKLF

--------------------------------------------------------------
>37548_37548_2_HPSE2-CWF19L1_HPSE2_chr10_100903995_ENST00000370549_CWF19L1_chr10_102003534_ENST00000354105_length(transcript)=2252nt_BP=670nt
AAGGACAATTAGTCACTAGCGAGACCCAGTAGGAAGAGAGGTTTAAATCAGAGGGATTGAATGAGGGTGCTTTGTGCCTTCCCTGAAGCC
ATGCCCTCCAGCAACTCCCGCCCCCCCGCGTGCCTAGCCCCGGGGGCTCTCTACTTGGCTCTGTTGCTCCATCTCTCCCTTTCCTCCCAG
GCTGGAGACAGGAGACCCTTGCCTGTAGACAGAGCTGCAGGTTTGAAGGAAAAGACCCTGATTCTACTTGATGTGAGCACCAAGAACCCA
GTCAGGACAGTCAATGAGAACTTCCTCTCTCTGCAGCTGGATCCGTCCATCATTCATGATGGCTGGCTCGATTTCCTAAGCTCCAAGCGC
TTGGTGACCCTGGCCCGGGGACTTTCGCCCGCCTTTCTGCGCTTCGGGGGCAAAAGGACCGACTTCCTGCAGTTCCAGAACCTGAGGAAC
CCGGCGAAAAGCCGCGGGGGCCCGGGCCCGGATTACTATCTCAAAAACTATGAGGATGACATTGTTCGAAGTGATGTTGCCTTAGATAAA
CAGAAAGGCTGCAAGATTGCCCAGCACCCTGATGTTATGCTGGAGCTCCAAAGGGAGAAGGCAGCTCAGATGCATCTGGTTCTTCTAAAG
GAGCAATTCTCCAATACTTACAGTAATCTCATATTAACAGCTCAGCCTCCAGGACCCTGCTGGTTTTGCCTTGCTAGCCCTGAAGTGGAA
AAACATTTGGTGGTCAACATCGGCACACATTGCTACCTTGCCCTGGCCAAAGGAGGCTTATCTGATGACCATGTCCTCATCCTGCCTATT
GGACACTACCAGTCAGTGGTGGAGCTTTCAGCAGAGGTGGTAGAAGAGGTGGAGAAGTATAAGGCCACTCTGAGACGGTTCTTTAAGAGT
CGAGGGAAATGGTGTGTTGTATTTGAGAGAAATTATAAGAGCCATCACCTCCAGCTACAGGTCATTCCTGTCCCAATCAGCTGCTCTACT
ACTGATGACATTAAAGATGCCTTCATTACCCAGGCACAGGAGCAGCAGATAGAGCTGTTGGAAATCCCAGAGCACTCTGACATCAAGCAG
ATTGCACAGCCAGGAGCAGCATATTTTTATGTTGAACTTGACACAGGAGAAAAGCTTTTCCACAGAATTAAAAAGAATTTTCCTTTGCAG
TTTGGAAGGGAGGTCCTGGCCAGTGAAGCCATCCTTAATGTTCCTGATAAGTCTGACTGGAGGCAGTGTCAGATCAGCAAGGAAGACGAG
GAGACCCTGGCTCGCCGCTTCCGGAAAGACTTTGAGCCCTATGACTTTACTCTGGATGACTAAAACAAAGGGAAGAACTTTTTATGAACT
CCACAGGAAGTAGTAAAGCTTTTTTTTTTTTTTAATTAAAAGAATTTTTTTTGAGACAAAGTCTCGCTCTGTCACCCAAGCAGGATTGCA
GTGGCATAACTGTGGCTCACTGTAGCCTCAACCTCCTGGGCTCTAGAGTTCCTCCCACCTCAGCCTCATGAGTAGCTGGGACCACAGGCG
CATGCTACCATGCCTGGCAAACTTTTTTGATTTTTTATAGAGACAGGAGGGTCTCCCTGTGTTGCCCAGGCTGGTCTGTAATGCCTAGGC
TCAAGGGATCCTCTGCCTTGGCTTCTTAACCTGCTGGGATTACAAGCATGAGACACCATTCCTGGCCTAGAAGCCTATTTTTAAAGAAAC
TACAATCTCCCATGGGGACTGTTTCCCTGCCTCTTTTGTGCAGTCCCATGGAACTTGCCTACAGCAAGAGGCCTAAGATTGAATCTTTTT
GGGGAAAAGTCATTCTAGGATGAAAATCCTATGTTAAGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGTACTTTGGGAAGCCGAGGC
AGGTGGATCACCTGAGGTGAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTTTACTAAAGCTACAAAAATTAGCTGGGC
GTGGTGCCAGGCACTTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAGCCTGGGAGGTGGAGGTTGCAGTGAGCCAA
GATCGCTCCATTGCACTCCAGCCTGGGTGACAGTGAAACTCCATCTCAAAAATAAAAGAATAAAAGTATGTCTGTCATCCAGCTCCTATG
TCTGTTATCCAGCTCCAAGTACAGCTTGTGTATATCAACATTTTCAAAAACCTTTAAACTACCAAATGAAATCCAGATGTTTTTCCATGG

>37548_37548_2_HPSE2-CWF19L1_HPSE2_chr10_100903995_ENST00000370549_CWF19L1_chr10_102003534_ENST00000354105_length(amino acids)=420AA_BP=203
MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTLILLDVSTKNPVRTVNENFLSLQLDPSIIHD
GWLDFLSSKRLVTLARGLSPAFLRFGGKRTDFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
AAQMHLVLLKEQFSNTYSNLILTAQPPGPCWFCLASPEVEKHLVVNIGTHCYLALAKGGLSDDHVLILPIGHYQSVVELSAEVVEEVEKY
KATLRRFFKSRGKWCVVFERNYKSHHLQLQVIPVPISCSTTDDIKDAFITQAQEQQIELLEIPEHSDIKQIAQPGAAYFYVELDTGEKLF

--------------------------------------------------------------
>37548_37548_3_HPSE2-CWF19L1_HPSE2_chr10_100903995_ENST00000370552_CWF19L1_chr10_102003534_ENST00000354105_length(transcript)=2252nt_BP=670nt
AAGGACAATTAGTCACTAGCGAGACCCAGTAGGAAGAGAGGTTTAAATCAGAGGGATTGAATGAGGGTGCTTTGTGCCTTCCCTGAAGCC
ATGCCCTCCAGCAACTCCCGCCCCCCCGCGTGCCTAGCCCCGGGGGCTCTCTACTTGGCTCTGTTGCTCCATCTCTCCCTTTCCTCCCAG
GCTGGAGACAGGAGACCCTTGCCTGTAGACAGAGCTGCAGGTTTGAAGGAAAAGACCCTGATTCTACTTGATGTGAGCACCAAGAACCCA
GTCAGGACAGTCAATGAGAACTTCCTCTCTCTGCAGCTGGATCCGTCCATCATTCATGATGGCTGGCTCGATTTCCTAAGCTCCAAGCGC
TTGGTGACCCTGGCCCGGGGACTTTCGCCCGCCTTTCTGCGCTTCGGGGGCAAAAGGACCGACTTCCTGCAGTTCCAGAACCTGAGGAAC
CCGGCGAAAAGCCGCGGGGGCCCGGGCCCGGATTACTATCTCAAAAACTATGAGGATGACATTGTTCGAAGTGATGTTGCCTTAGATAAA
CAGAAAGGCTGCAAGATTGCCCAGCACCCTGATGTTATGCTGGAGCTCCAAAGGGAGAAGGCAGCTCAGATGCATCTGGTTCTTCTAAAG
GAGCAATTCTCCAATACTTACAGTAATCTCATATTAACAGCTCAGCCTCCAGGACCCTGCTGGTTTTGCCTTGCTAGCCCTGAAGTGGAA
AAACATTTGGTGGTCAACATCGGCACACATTGCTACCTTGCCCTGGCCAAAGGAGGCTTATCTGATGACCATGTCCTCATCCTGCCTATT
GGACACTACCAGTCAGTGGTGGAGCTTTCAGCAGAGGTGGTAGAAGAGGTGGAGAAGTATAAGGCCACTCTGAGACGGTTCTTTAAGAGT
CGAGGGAAATGGTGTGTTGTATTTGAGAGAAATTATAAGAGCCATCACCTCCAGCTACAGGTCATTCCTGTCCCAATCAGCTGCTCTACT
ACTGATGACATTAAAGATGCCTTCATTACCCAGGCACAGGAGCAGCAGATAGAGCTGTTGGAAATCCCAGAGCACTCTGACATCAAGCAG
ATTGCACAGCCAGGAGCAGCATATTTTTATGTTGAACTTGACACAGGAGAAAAGCTTTTCCACAGAATTAAAAAGAATTTTCCTTTGCAG
TTTGGAAGGGAGGTCCTGGCCAGTGAAGCCATCCTTAATGTTCCTGATAAGTCTGACTGGAGGCAGTGTCAGATCAGCAAGGAAGACGAG
GAGACCCTGGCTCGCCGCTTCCGGAAAGACTTTGAGCCCTATGACTTTACTCTGGATGACTAAAACAAAGGGAAGAACTTTTTATGAACT
CCACAGGAAGTAGTAAAGCTTTTTTTTTTTTTTAATTAAAAGAATTTTTTTTGAGACAAAGTCTCGCTCTGTCACCCAAGCAGGATTGCA
GTGGCATAACTGTGGCTCACTGTAGCCTCAACCTCCTGGGCTCTAGAGTTCCTCCCACCTCAGCCTCATGAGTAGCTGGGACCACAGGCG
CATGCTACCATGCCTGGCAAACTTTTTTGATTTTTTATAGAGACAGGAGGGTCTCCCTGTGTTGCCCAGGCTGGTCTGTAATGCCTAGGC
TCAAGGGATCCTCTGCCTTGGCTTCTTAACCTGCTGGGATTACAAGCATGAGACACCATTCCTGGCCTAGAAGCCTATTTTTAAAGAAAC
TACAATCTCCCATGGGGACTGTTTCCCTGCCTCTTTTGTGCAGTCCCATGGAACTTGCCTACAGCAAGAGGCCTAAGATTGAATCTTTTT
GGGGAAAAGTCATTCTAGGATGAAAATCCTATGTTAAGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGTACTTTGGGAAGCCGAGGC
AGGTGGATCACCTGAGGTGAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTTTACTAAAGCTACAAAAATTAGCTGGGC
GTGGTGCCAGGCACTTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAGCCTGGGAGGTGGAGGTTGCAGTGAGCCAA
GATCGCTCCATTGCACTCCAGCCTGGGTGACAGTGAAACTCCATCTCAAAAATAAAAGAATAAAAGTATGTCTGTCATCCAGCTCCTATG
TCTGTTATCCAGCTCCAAGTACAGCTTGTGTATATCAACATTTTCAAAAACCTTTAAACTACCAAATGAAATCCAGATGTTTTTCCATGG

>37548_37548_3_HPSE2-CWF19L1_HPSE2_chr10_100903995_ENST00000370552_CWF19L1_chr10_102003534_ENST00000354105_length(amino acids)=420AA_BP=203
MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTLILLDVSTKNPVRTVNENFLSLQLDPSIIHD
GWLDFLSSKRLVTLARGLSPAFLRFGGKRTDFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
AAQMHLVLLKEQFSNTYSNLILTAQPPGPCWFCLASPEVEKHLVVNIGTHCYLALAKGGLSDDHVLILPIGHYQSVVELSAEVVEEVEKY
KATLRRFFKSRGKWCVVFERNYKSHHLQLQVIPVPISCSTTDDIKDAFITQAQEQQIELLEIPEHSDIKQIAQPGAAYFYVELDTGEKLF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HPSE2-CWF19L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HPSE2-CWF19L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HPSE2-CWF19L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource