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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HS2ST1-SH3GLB1 (FusionGDB2 ID:37593)

Fusion Gene Summary for HS2ST1-SH3GLB1

Fusion gene summary

Fusion gene information	Fusion gene name: HS2ST1-SH3GLB1
	Fusion gene ID: 37593
		Hgene	Tgene
	Gene symbol	HS2ST1	SH3GLB1
	Gene ID	9653	51100
	Gene name	heparan sulfate 2-O-sulfotransferase 1	SH3 domain containing GRB2 like, endophilin B1
	Synonyms	dJ604K5.2	Bif-1\|CGI-61\|PPP1R70\|dJ612B15.2
	Cytomap	1p22.3	1p22.3
	Type of gene	protein-coding	protein-coding
	Description	heparan sulfate 2-O-sulfotransferase 12-O-sulfotransferase2OST	endophilin-B1Bax-interacting factor 1SH3 domain-containing GRB2-like protein B1SH3-containing protein SH3GLB1SH3-domain GRB2 like endophilin B1protein phosphatase 1, regulatory subunit 70testicular tissue protein Li 172
	Modification date	20200313	20200313
	UniProtAcc	Q7LGA3	.
	Ensembl transtripts involved in fusion gene	ENST00000370550, ENST00000370551, ENST00000356813,	ENST00000482504, ENST00000535010, ENST00000370558,
Fusion gene scores	* DoF score	11 X 5 X 7=385	4 X 4 X 3=48
	# samples	12	4
	** MAII score	log2(12/385*10)=-1.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HS2ST1 [Title/Abstract] AND SH3GLB1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HS2ST1(87380843)-SH3GLB1(87185190), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SH3GLB1	GO:0031334	positive regulation of protein complex assembly	19074440

Fusion gene breakpoints across HS2ST1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SH3GLB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-DD-AAEG-01A	HS2ST1	chr1	87380843	-	SH3GLB1	chr1	87185190	+
ChimerDB4	LIHC	TCGA-DD-AAEG-01A	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+
ChimerDB4	LIHC	TCGA-DD-AAEG	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+

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Fusion Gene ORF analysis for HS2ST1-SH3GLB1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000370550	ENST00000482504	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+
5CDS-5UTR	ENST00000370550	ENST00000535010	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+
5CDS-5UTR	ENST00000370551	ENST00000482504	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+
5CDS-5UTR	ENST00000370551	ENST00000535010	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+
In-frame	ENST00000370550	ENST00000370558	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+
In-frame	ENST00000370551	ENST00000370558	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+
intron-3CDS	ENST00000356813	ENST00000370558	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+
intron-5UTR	ENST00000356813	ENST00000482504	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+
intron-5UTR	ENST00000356813	ENST00000535010	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000370551

HS2ST1

chr1

87380843

ENST00000370558

SH3GLB1

chr1

87185190

6346

513

389

1396

335

ENST00000370550

HS2ST1

chr1

87380843

ENST00000370558

SH3GLB1

chr1

87185190

6320

487

363

1370

335

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000370551	ENST00000370558	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+	0.00025037	0.9997496
ENST00000370550	ENST00000370558	HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185190	+	0.000248892	0.99975115

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Fusion Genomic Features for HS2ST1-SH3GLB1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185189	+	9.19E-08	0.9999999
HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185189	+	9.19E-08	0.9999999
HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185189	+	9.19E-08	0.9999999
HS2ST1	chr1	87380843	+	SH3GLB1	chr1	87185189	+	9.19E-08	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HS2ST1-SH3GLB1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:87380843/chr1:87185190)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HS2ST1 Q7LGA3	.
FUNCTION: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HS2ST1

chr1:87380843

chr1:87185190

ENST00000370550

1_11

357.0

Topological domain

Cytoplasmic

Hgene

HS2ST1

chr1:87380843

chr1:87185190

ENST00000370551

1_11

230.0

Topological domain

Cytoplasmic

Hgene

HS2ST1

chr1:87380843

chr1:87185190

ENST00000370550

12_28

357.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

HS2ST1

chr1:87380843

chr1:87185190

ENST00000370551

12_28

230.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000370558

155_195

366.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000482504

155_195

387.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000535010

155_195

266.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000370558

305_365

366.0

Domain

SH3

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000482504

305_365

387.0

Domain

SH3

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000535010

27_261

266.0

Domain

BAR

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000535010

305_365

266.0

Domain

SH3

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000535010

1_30

266.0

Region

Note=Membrane-binding amphipathic helix

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000535010

1_37

266.0

Region

Required for membrane binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HS2ST1

chr1:87380843

chr1:87185190

ENST00000370550

29_356

357.0

Topological domain

Lumenal

Hgene

HS2ST1

chr1:87380843

chr1:87185190

ENST00000370551

29_356

230.0

Topological domain

Lumenal

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000370558

27_261

366.0

Domain

BAR

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000482504

27_261

387.0

Domain

BAR

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000370558

1_30

366.0

Region

Note=Membrane-binding amphipathic helix

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000370558

1_37

366.0

Region

Required for membrane binding

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000482504

1_30

387.0

Region

Note=Membrane-binding amphipathic helix

Tgene

SH3GLB1

chr1:87380843

chr1:87185190

ENST00000482504

1_37

387.0

Region

Required for membrane binding

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Fusion Gene Sequence for HS2ST1-SH3GLB1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>37593_37593_1_HS2ST1-SH3GLB1_HS2ST1_chr1_87380843_ENST00000370550_SH3GLB1_chr1_87185190_ENST00000370558_length(transcript)=6320nt_BP=487nt
AAAGGAGGGAGGGAAGGAAGGAAGAGAGGGAGGCGGGCAAGCAGGCGGGCGCGGGGGTCGGGGACTGAGGCAGTAGAGGGAGGCGAGAGC
CCGGCAGCCGCTTCGCGCTGTTTGCTGCGCGGGCTTTTGGAGGGGGCGGCCGTTTAGTCGGCTGAGGAGAAGCGGACACCAGCGGCGTTG
GTGATAGCGCCTGGGGGAGGGGGACTGGAGAGGCGAGAAGGGGGGTCGCTGCGGTGGTTCTCTCGCTGTCGCTCTCTCTTTGCCTCGCTC
CCGGCTCGGCGGGCTCCTCCCGGCGTCTCTCTCGCCTCCGGGGTCCCGCTCCCCGCCCCCCGCGGTATGTCTTGATCCCGAGCAGCGGGT
TTCATGGGGCTCCTCAGGATTATGATGCCGCCCAAGTTGCAGCTGCTGGCGGTGGTGGCCTTCGCGGTGGCGATGCTCTTCTTGGAAAAC
CAGATCCAGAAACTGGAGGAGTCCCGCTCGAAGCTAGATGCCAGGATAGAAGAATTTGTTTATGAGAAACTGGATAGAAAAGCTCCAAGT
CGTATAAACAACCCAGAACTTTTGGGACAATATATGATTGATGCAGGGACTGAGTTTGGCCCAGGAACAGCTTATGGTAATGCCCTTATT
AAATGTGGAGAAACCCAAAAAAGAATTGGAACAGCAGACAGAGAACTGATTCAAACGTCAGCCTTAAATTTTCTTACTCCTTTAAGAAAC
TTTATAGAAGGAGATTACAAAACAATTGCTAAAGAAAGGAAACTATTGCAAAATAAGAGACTGGATTTGGATGCTGCAAAAACGAGACTA
AAAAAGGCAAAAGCTGCAGAAACTAGAAATTCATCTGAACAGGAATTAAGAATAACTCAAAGTGAATTTGATCGTCAAGCAGAGATTACC
AGACTTCTGCTAGAGGGAATCAGCAGTACACATGCCCATCACCTTCGCTGTCTGAATGACTTTGTAGAAGCCCAGATGACTTACTATGCA
CAGTGTTACCAGTATATGTTGGACCTCCAGAAACAACTGGGAAGTTTTCCATCCAATTATCTTAGTAACAACAATCAGACTTCTGTGACA
CCTGTACCATCAGTTTTACCAAATGCGATTGGTTCTTCTGCCATGGCTTCAACAAGTGGCCTAGTAATCACCTCTCCTTCCAACCTCAGT
GACCTTAAGGAGTGTAGTGGCAGCAGAAAGGCCAGGGTTCTCTATGATTATGATGCAGCAAACAGTACTGAATTATCACTTCTGGCAGAT
GAGGTGATCACTGTGTTCAGTGTTGTTGGAATGGATTCAGACTGGCTAATGGGGGAAAGGGGAAACCAGAAGGGCAAGGTGCCAATTACC
TACTTAGAACTGCTCAATTAAGTAGGTGGACTATGGAAAGGTTGCCCATCATGACTTTGTATTTATATACAATTAACTCTAAATAAAGCA
GGTTAAGTATCTTCCATGTTAATGTGTTAAGAGACTGAAAATACCAGCCATCAGAAACTGGCCTTTCTGCCAATAAAGTTGCATGGTAAA
TATTTCATTACAGAATTTATGTTAGAGCTTTCATGCCAAGAATGTTTTCTTACAAAATTCTCTTTTTATTGAGGTTTCACTAATAAGCAG
CTTCTACTTTTGAGCCTCAACTTAAAGCAGAACTGTTTTCTACTGGATTTTTCATTAACAGCAAGCTTTTTCTTTTATGTAAAATAAATC
TATTGTGAATTGATATCAGCGACTCATTTATTAGGTATAAATAATAGCCAAAGAATAAAATTAAAATTTATTTTAAACTTTCGGTCTTAA
AAAGAGCTGTAGGATATAAACCTCTTTTGTGAAAAGTAGAATTTTCTGAATGCTTTCATAGACAAAAACGCATTTAAACTATGTTTACCT
GGTTTTCCAACAGAAATCAAATGATTTTAATATTATGTTTTGATGGGTTATTTTCAGAGTTGTTTGGTTTTTTAAACACTACTGAATGGT
TTCTTTTAAATTTAAGAACAACTAGTTCTTGAAAAGCAATACCGTATTTCTCTGATAAATTTGTAGTTAAGGTTCTAGAAAATCTAGGAC
AAATTTACTTCATTAAACATAAAGTTTTTAAGATTATTCAGTTGGCACAATTTAATGCATAATTGGGATTGGATCCATTTACTGTACTGT
GGTACAGTAAAGAGAATGTGTTCTTATTGAACAGCAGATTTGTATACAAATACGGAATAATGCAACTACATTATAAATTGTATACGAACA
AAATAAATTGGGTCACTCTGAGCTTACTATTAAAACATTGAAAATTTATTAATGAACACAGGCTATCTTGATGAGGATCTCTGCTTATGA
AACACATACTAATGAAATTATTAGTGACACATTGGAAGCTAGAAAATTGCTGTTGGGGCCATTGCTATAAATCATTGTTTCCATGTTAAG
ACTTCTGTTCTAATTCATTCATTCAACAAACATTTGTTGAGGGCCAGATACTGTGCTGGTCAACTGGGGATACTGTCCTGAACAATATGC
ACACAGTTCTTGCCCCTGCAGAGCTTAAAGACCATTAAAGGATACAGAAAATTAAGCAATTATCCTATAGTAGGATTCGTGGTGTGATGG
GGAAAATACAAGGTACTGTATTTGGGAGTCATGTAACTCCAGTTTTGGGAGTGAGAGAGGGTCTGGGGAAGAACTGTTCCAGATAAAAAG
ATGTGTAACCAAGATAGCATAGCACATTCTGACAACTAAAGCAATTTACTCTAACTTAAGCATGAAGTACAAAAGTATAGTTCATTTATT
GAGGGAATGTTAAGCTATTAAAATGATACTTTTTGGTACTTTTAAAAAAATGAATACTTAAACACCGTTTTAAAATTTTGTGTTAAGAGC
TCCTAATAAGAACTTGGTAAACATGTTGACAATTTAACTCACAGTCTAAACTTTAAAAGTAGTAGTTACCCTTTTATTTCTGTGCCATGA
GACAAATTCTTCTGCAGTTTTATAGTTGTACAAGATGTTTTGACTCACTCTCAATTGCCATATTCTTAAAGAAACCCTGAAAAGCTGCTC
AAGCTGGTCAGTTTTCTGTAAAACCAAGTAAATGAAATTTTCTCTCCCCTCAGAAAGGAAGTTCTACAGCCTAGAGTACCATCTATTGTG
TTTTATAAGTCCAGATTTAGGCTTTGAAAGATCATACCAAAACTTCAGATCGACTTAAACAGCAACTATGAATTAGGTTTATGGGAAATG
TAGTAATACAGGGGAAAGAATATCGGTAATGGAGTGAAATGGTCCTGGGTTCAAATCCAGTCTTCCTCACATATTGTGCTCTTTAAGCTT
CAAATGAGATGTATAACTGCCTTTTCCTTACCAGTAAAATGAGGACAATAATTATGACACCATAGGGTGGTTGTGAGGATTAGCAAATGT
TATCTTGTATTTCAGGTGCCTTTCAGGGAAAGGCTTGGCACATAGTAAACACATCCTGTAAATATCAGTTTCCCCTTGTTAGCCCCTGTA
GCATCCTGACCTACCAAGTCTATAGGCCTTGCATATCACTGTGCACCAGAGATACCTCTTTTACATCTGGGCTCTGTTTTCTCTCTATCA
ATCCTATCCTCCACCCTCTTTAAATCAGACCCCAGGTTTAACCTTCCCACAGTCAGTATAAATCATTTTTCAGAACTTTCAGCTTTCCAT
CAAGTGAAAGTTGATTTTAGTTACCCAGTAATGTACAGAAACCTTCAATAATGTTAAGCTTCAAAGGCTTCTGGTACGTTTGTCTACCAC
AGAACCACCACAATATATATGCTTGTTCTTAGGTTTATTGCTTTTTATTTTAATGGGGTTTGGTTGTTTGGGTTTTATTTTGGTTTTGGC
TTATTTTAAAGTCAAGTTTAGTTTTTACTCAGGTAAAGGCCTGAAGTTTCTTGGGCGTGGAAGAAAAAGCTTGGGAAGCCTATTAATTCA
TGGTGCAGTTCAGAATTGTTTAAATAAGCTCTGTGCCACTGAGCTTAATCTGAAAGTATAGTGACATGTGAAGGATGCACATATGAATGA
AAAACTAAAATAATTGTAGGCTCTTCTATAAATGAAAAAAAAAGTGATTGGATTGTGTCTACCTTTTTCCTCAAAGTAATCTAACCTAAA
CGGTCATGGTGTTAAAACTTTTTATGGTGCTAATCAGAAAAATTGATGTTGCAAGAAATGAGGTCTCAAAAATGGGAATGTGCCTCCTCA
CTCTGCGTCACATGGGAAATAAATCCTGAGGCCAGGATCACCAGTGGGGTAGAGTCATCTTCATAGTCTCCTGTTATCCTCCCCCTGAAC
AAAGAACAAAGTGAGACTGGGAAGCTAGTGTTGGGGAAACATTTCTGGGATAAACTGTGGAGTGGAGAAGACAATGGAGGGCAAGGCAAA
AACCCACAGACTTGTTTACCCATAGAGGCCCCACTCACCTCCATGCTGACAGAATTCCAGAAAAATTCCTTCCCTATCTCCCAAACACCT
GAAATTCTGAAATATTGCCCTACTATTTAGCACTTTAAGCTTCAGTGAGGTGCTGTAATGGAGAGATAGCTTCATAGTTTAGCCTATAGC
CAACTTTGCCTCAAGACCTCCAGATAAGATGAAGTGGCTTTTACCTCATGTGAGTCTCAAACGCTGGAGAGAGAGTTCCACAACCACCCC
TGCCCTTTCTCCCATATTACGCTCATTAGAAAGTCTACTCAGGGCTGGGTGCCGTGGCTCATGCCTGTAATCCCAGCACTTTGGAGGCTG
AGGCGGGTGGATCATCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGGGAAACCCTGTCTCTACTGAAAATATAAAAATTAGCC
GGGCATGGTGGCGTGCACCTGTAATTCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCCAGAGGCAGAGGCTACAGTGAG
CCAAGATTGCACCACTGCACTCCAACCTGGGTGATAGAATAAGACTCTTGTCTCAAGGAAAGAAAAAATGTCTACTCAGTAGAGCAGTGA
TTGGCAAAGTGTGAGACCCCAGACCGGCAATATTGGCATCTCCTGGAGACTTGTTTAAAATGCTGATTACTATTTTCAAGAACTTTCTAC
CTTCATTTTTACTTATTTTTTGTTTTCAAGGGCTCATGGAATCAGTCTTCCATGTGACAGCTTTTTAAATATTTTAAGACAAAAACTGAG
TCTTCTAATCTTAATTGTGTTCTAGCAGTAGTCATTGTAATTATAGTTATTTTTATAATTTATTTGTTTAGTGTATATCTGTCACTCTAG
AATGTAGGCTCCCTGAGATAAAAACTATAATTCTTTTGATGGCAGTTACATTCCCAACTCTTAGCACAAGATCTAGGACATAGTATGAAC
TCAATAAATTTTTGTTGAATGAAAGAAAAATGCAAATTTATAAGCCTTTTCAGAGACCTACTGAATCAAACTCTGAGAGTGGAGCCCAGC
AATCTGTTGTAAAAGCTGTTTGAGTAATACTGTTGCACTCTAAGCTTGAGAACCACTGCAATAGAACTAAGAGAACATTCATTTCACCTT
CAGGCCTATTCTCTGACATCACTTGAAAAATCCTCTCTGCCTTCTGTAACCCTTAACCAACAACAGTGCCCTGTCCATGTAGGGGAAACT
TCTGGGCTGTATTACAAGTGGGTAGGAAGGTATAAGGATATCATAGTGGGAAGTATTGCTTAGAATGCCAGTACTTGTTTGCTGTGGAAG
GTTTCTAGGAATGGATTGCTTAGTCTAAAGTAAGCACTACCACCATCCACGTTTTCACTCAACACAGTGCCTTTTAATTGGTGACTAACA
TCAAAACACCTTGACAAACCGTTAAAACAGTATCAGAAACCATGTGTACATCCCTGTGCCTCTTAGATTGCTAAGTTCTGCTCTCATTCT
TACTTCAAAGGACACTTTTTAAAGAATTGTTAATGCTTTTTTATAATACAAGTCATAGCCCTGTTGGCAAAAAGAAAAAAGATTCAGTGA
GAAAGAAAAATCACTGATAATTCCATCATCCAGGGAGAACCACTGTTATTTAAGTATATGGCCTTCCAGACTTTTCTGTGCATTTATAGA
TATTTTTAATGGGATCAAAGTGTACATACTGTTTTGTAACTTTTTTTCACTCAACAATACCATGACTGTCTTGCTGTGTCAAGTATATTT
CTACATCTCTTAATGGCTGCATGATATTCCATCATATGTGCCACATTTTATTAAACTACTGTTCAATTTTTAGGTTTCCAACTTTCATTA

>37593_37593_1_HS2ST1-SH3GLB1_HS2ST1_chr1_87380843_ENST00000370550_SH3GLB1_chr1_87185190_ENST00000370558_length(amino acids)=335AA_BP=33
MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLDARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIK
CGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQELRITQSEFDRQAEITR
LLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSD

--------------------------------------------------------------
>37593_37593_2_HS2ST1-SH3GLB1_HS2ST1_chr1_87380843_ENST00000370551_SH3GLB1_chr1_87185190_ENST00000370558_length(transcript)=6346nt_BP=513nt
CGGTGGAGGGGCGCGCGGCCGCGAGCAAAGGAGGGAGGGAAGGAAGGAAGAGAGGGAGGCGGGCAAGCAGGCGGGCGCGGGGGTCGGGGA
CTGAGGCAGTAGAGGGAGGCGAGAGCCCGGCAGCCGCTTCGCGCTGTTTGCTGCGCGGGCTTTTGGAGGGGGCGGCCGTTTAGTCGGCTG
AGGAGAAGCGGACACCAGCGGCGTTGGTGATAGCGCCTGGGGGAGGGGGACTGGAGAGGCGAGAAGGGGGGTCGCTGCGGTGGTTCTCTC
GCTGTCGCTCTCTCTTTGCCTCGCTCCCGGCTCGGCGGGCTCCTCCCGGCGTCTCTCTCGCCTCCGGGGTCCCGCTCCCCGCCCCCCGCG
GTATGTCTTGATCCCGAGCAGCGGGTTTCATGGGGCTCCTCAGGATTATGATGCCGCCCAAGTTGCAGCTGCTGGCGGTGGTGGCCTTCG
CGGTGGCGATGCTCTTCTTGGAAAACCAGATCCAGAAACTGGAGGAGTCCCGCTCGAAGCTAGATGCCAGGATAGAAGAATTTGTTTATG
AGAAACTGGATAGAAAAGCTCCAAGTCGTATAAACAACCCAGAACTTTTGGGACAATATATGATTGATGCAGGGACTGAGTTTGGCCCAG
GAACAGCTTATGGTAATGCCCTTATTAAATGTGGAGAAACCCAAAAAAGAATTGGAACAGCAGACAGAGAACTGATTCAAACGTCAGCCT
TAAATTTTCTTACTCCTTTAAGAAACTTTATAGAAGGAGATTACAAAACAATTGCTAAAGAAAGGAAACTATTGCAAAATAAGAGACTGG
ATTTGGATGCTGCAAAAACGAGACTAAAAAAGGCAAAAGCTGCAGAAACTAGAAATTCATCTGAACAGGAATTAAGAATAACTCAAAGTG
AATTTGATCGTCAAGCAGAGATTACCAGACTTCTGCTAGAGGGAATCAGCAGTACACATGCCCATCACCTTCGCTGTCTGAATGACTTTG
TAGAAGCCCAGATGACTTACTATGCACAGTGTTACCAGTATATGTTGGACCTCCAGAAACAACTGGGAAGTTTTCCATCCAATTATCTTA
GTAACAACAATCAGACTTCTGTGACACCTGTACCATCAGTTTTACCAAATGCGATTGGTTCTTCTGCCATGGCTTCAACAAGTGGCCTAG
TAATCACCTCTCCTTCCAACCTCAGTGACCTTAAGGAGTGTAGTGGCAGCAGAAAGGCCAGGGTTCTCTATGATTATGATGCAGCAAACA
GTACTGAATTATCACTTCTGGCAGATGAGGTGATCACTGTGTTCAGTGTTGTTGGAATGGATTCAGACTGGCTAATGGGGGAAAGGGGAA
ACCAGAAGGGCAAGGTGCCAATTACCTACTTAGAACTGCTCAATTAAGTAGGTGGACTATGGAAAGGTTGCCCATCATGACTTTGTATTT
ATATACAATTAACTCTAAATAAAGCAGGTTAAGTATCTTCCATGTTAATGTGTTAAGAGACTGAAAATACCAGCCATCAGAAACTGGCCT
TTCTGCCAATAAAGTTGCATGGTAAATATTTCATTACAGAATTTATGTTAGAGCTTTCATGCCAAGAATGTTTTCTTACAAAATTCTCTT
TTTATTGAGGTTTCACTAATAAGCAGCTTCTACTTTTGAGCCTCAACTTAAAGCAGAACTGTTTTCTACTGGATTTTTCATTAACAGCAA
GCTTTTTCTTTTATGTAAAATAAATCTATTGTGAATTGATATCAGCGACTCATTTATTAGGTATAAATAATAGCCAAAGAATAAAATTAA
AATTTATTTTAAACTTTCGGTCTTAAAAAGAGCTGTAGGATATAAACCTCTTTTGTGAAAAGTAGAATTTTCTGAATGCTTTCATAGACA
AAAACGCATTTAAACTATGTTTACCTGGTTTTCCAACAGAAATCAAATGATTTTAATATTATGTTTTGATGGGTTATTTTCAGAGTTGTT
TGGTTTTTTAAACACTACTGAATGGTTTCTTTTAAATTTAAGAACAACTAGTTCTTGAAAAGCAATACCGTATTTCTCTGATAAATTTGT
AGTTAAGGTTCTAGAAAATCTAGGACAAATTTACTTCATTAAACATAAAGTTTTTAAGATTATTCAGTTGGCACAATTTAATGCATAATT
GGGATTGGATCCATTTACTGTACTGTGGTACAGTAAAGAGAATGTGTTCTTATTGAACAGCAGATTTGTATACAAATACGGAATAATGCA
ACTACATTATAAATTGTATACGAACAAAATAAATTGGGTCACTCTGAGCTTACTATTAAAACATTGAAAATTTATTAATGAACACAGGCT
ATCTTGATGAGGATCTCTGCTTATGAAACACATACTAATGAAATTATTAGTGACACATTGGAAGCTAGAAAATTGCTGTTGGGGCCATTG
CTATAAATCATTGTTTCCATGTTAAGACTTCTGTTCTAATTCATTCATTCAACAAACATTTGTTGAGGGCCAGATACTGTGCTGGTCAAC
TGGGGATACTGTCCTGAACAATATGCACACAGTTCTTGCCCCTGCAGAGCTTAAAGACCATTAAAGGATACAGAAAATTAAGCAATTATC
CTATAGTAGGATTCGTGGTGTGATGGGGAAAATACAAGGTACTGTATTTGGGAGTCATGTAACTCCAGTTTTGGGAGTGAGAGAGGGTCT
GGGGAAGAACTGTTCCAGATAAAAAGATGTGTAACCAAGATAGCATAGCACATTCTGACAACTAAAGCAATTTACTCTAACTTAAGCATG
AAGTACAAAAGTATAGTTCATTTATTGAGGGAATGTTAAGCTATTAAAATGATACTTTTTGGTACTTTTAAAAAAATGAATACTTAAACA
CCGTTTTAAAATTTTGTGTTAAGAGCTCCTAATAAGAACTTGGTAAACATGTTGACAATTTAACTCACAGTCTAAACTTTAAAAGTAGTA
GTTACCCTTTTATTTCTGTGCCATGAGACAAATTCTTCTGCAGTTTTATAGTTGTACAAGATGTTTTGACTCACTCTCAATTGCCATATT
CTTAAAGAAACCCTGAAAAGCTGCTCAAGCTGGTCAGTTTTCTGTAAAACCAAGTAAATGAAATTTTCTCTCCCCTCAGAAAGGAAGTTC
TACAGCCTAGAGTACCATCTATTGTGTTTTATAAGTCCAGATTTAGGCTTTGAAAGATCATACCAAAACTTCAGATCGACTTAAACAGCA
ACTATGAATTAGGTTTATGGGAAATGTAGTAATACAGGGGAAAGAATATCGGTAATGGAGTGAAATGGTCCTGGGTTCAAATCCAGTCTT
CCTCACATATTGTGCTCTTTAAGCTTCAAATGAGATGTATAACTGCCTTTTCCTTACCAGTAAAATGAGGACAATAATTATGACACCATA
GGGTGGTTGTGAGGATTAGCAAATGTTATCTTGTATTTCAGGTGCCTTTCAGGGAAAGGCTTGGCACATAGTAAACACATCCTGTAAATA
TCAGTTTCCCCTTGTTAGCCCCTGTAGCATCCTGACCTACCAAGTCTATAGGCCTTGCATATCACTGTGCACCAGAGATACCTCTTTTAC
ATCTGGGCTCTGTTTTCTCTCTATCAATCCTATCCTCCACCCTCTTTAAATCAGACCCCAGGTTTAACCTTCCCACAGTCAGTATAAATC
ATTTTTCAGAACTTTCAGCTTTCCATCAAGTGAAAGTTGATTTTAGTTACCCAGTAATGTACAGAAACCTTCAATAATGTTAAGCTTCAA
AGGCTTCTGGTACGTTTGTCTACCACAGAACCACCACAATATATATGCTTGTTCTTAGGTTTATTGCTTTTTATTTTAATGGGGTTTGGT
TGTTTGGGTTTTATTTTGGTTTTGGCTTATTTTAAAGTCAAGTTTAGTTTTTACTCAGGTAAAGGCCTGAAGTTTCTTGGGCGTGGAAGA
AAAAGCTTGGGAAGCCTATTAATTCATGGTGCAGTTCAGAATTGTTTAAATAAGCTCTGTGCCACTGAGCTTAATCTGAAAGTATAGTGA
CATGTGAAGGATGCACATATGAATGAAAAACTAAAATAATTGTAGGCTCTTCTATAAATGAAAAAAAAAGTGATTGGATTGTGTCTACCT
TTTTCCTCAAAGTAATCTAACCTAAACGGTCATGGTGTTAAAACTTTTTATGGTGCTAATCAGAAAAATTGATGTTGCAAGAAATGAGGT
CTCAAAAATGGGAATGTGCCTCCTCACTCTGCGTCACATGGGAAATAAATCCTGAGGCCAGGATCACCAGTGGGGTAGAGTCATCTTCAT
AGTCTCCTGTTATCCTCCCCCTGAACAAAGAACAAAGTGAGACTGGGAAGCTAGTGTTGGGGAAACATTTCTGGGATAAACTGTGGAGTG
GAGAAGACAATGGAGGGCAAGGCAAAAACCCACAGACTTGTTTACCCATAGAGGCCCCACTCACCTCCATGCTGACAGAATTCCAGAAAA
ATTCCTTCCCTATCTCCCAAACACCTGAAATTCTGAAATATTGCCCTACTATTTAGCACTTTAAGCTTCAGTGAGGTGCTGTAATGGAGA
GATAGCTTCATAGTTTAGCCTATAGCCAACTTTGCCTCAAGACCTCCAGATAAGATGAAGTGGCTTTTACCTCATGTGAGTCTCAAACGC
TGGAGAGAGAGTTCCACAACCACCCCTGCCCTTTCTCCCATATTACGCTCATTAGAAAGTCTACTCAGGGCTGGGTGCCGTGGCTCATGC
CTGTAATCCCAGCACTTTGGAGGCTGAGGCGGGTGGATCATCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGGGAAACCCTGT
CTCTACTGAAAATATAAAAATTAGCCGGGCATGGTGGCGTGCACCTGTAATTCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGA
ACCCCAGAGGCAGAGGCTACAGTGAGCCAAGATTGCACCACTGCACTCCAACCTGGGTGATAGAATAAGACTCTTGTCTCAAGGAAAGAA
AAAATGTCTACTCAGTAGAGCAGTGATTGGCAAAGTGTGAGACCCCAGACCGGCAATATTGGCATCTCCTGGAGACTTGTTTAAAATGCT
GATTACTATTTTCAAGAACTTTCTACCTTCATTTTTACTTATTTTTTGTTTTCAAGGGCTCATGGAATCAGTCTTCCATGTGACAGCTTT
TTAAATATTTTAAGACAAAAACTGAGTCTTCTAATCTTAATTGTGTTCTAGCAGTAGTCATTGTAATTATAGTTATTTTTATAATTTATT
TGTTTAGTGTATATCTGTCACTCTAGAATGTAGGCTCCCTGAGATAAAAACTATAATTCTTTTGATGGCAGTTACATTCCCAACTCTTAG
CACAAGATCTAGGACATAGTATGAACTCAATAAATTTTTGTTGAATGAAAGAAAAATGCAAATTTATAAGCCTTTTCAGAGACCTACTGA
ATCAAACTCTGAGAGTGGAGCCCAGCAATCTGTTGTAAAAGCTGTTTGAGTAATACTGTTGCACTCTAAGCTTGAGAACCACTGCAATAG
AACTAAGAGAACATTCATTTCACCTTCAGGCCTATTCTCTGACATCACTTGAAAAATCCTCTCTGCCTTCTGTAACCCTTAACCAACAAC
AGTGCCCTGTCCATGTAGGGGAAACTTCTGGGCTGTATTACAAGTGGGTAGGAAGGTATAAGGATATCATAGTGGGAAGTATTGCTTAGA
ATGCCAGTACTTGTTTGCTGTGGAAGGTTTCTAGGAATGGATTGCTTAGTCTAAAGTAAGCACTACCACCATCCACGTTTTCACTCAACA
CAGTGCCTTTTAATTGGTGACTAACATCAAAACACCTTGACAAACCGTTAAAACAGTATCAGAAACCATGTGTACATCCCTGTGCCTCTT
AGATTGCTAAGTTCTGCTCTCATTCTTACTTCAAAGGACACTTTTTAAAGAATTGTTAATGCTTTTTTATAATACAAGTCATAGCCCTGT
TGGCAAAAAGAAAAAAGATTCAGTGAGAAAGAAAAATCACTGATAATTCCATCATCCAGGGAGAACCACTGTTATTTAAGTATATGGCCT
TCCAGACTTTTCTGTGCATTTATAGATATTTTTAATGGGATCAAAGTGTACATACTGTTTTGTAACTTTTTTTCACTCAACAATACCATG
ACTGTCTTGCTGTGTCAAGTATATTTCTACATCTCTTAATGGCTGCATGATATTCCATCATATGTGCCACATTTTATTAAACTACTGTTC

>37593_37593_2_HS2ST1-SH3GLB1_HS2ST1_chr1_87380843_ENST00000370551_SH3GLB1_chr1_87185190_ENST00000370558_length(amino acids)=335AA_BP=33
MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLDARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIK
CGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQELRITQSEFDRQAEITR
LLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSD

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Fusion Gene PPI Analysis for HS2ST1-SH3GLB1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for HS2ST1-SH3GLB1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HS2ST1-SH3GLB1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source