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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HSD11B1L-SAFB (FusionGDB2 ID:37644)

Fusion Gene Summary for HSD11B1L-SAFB

check button Fusion gene summary
Fusion gene informationFusion gene name: HSD11B1L-SAFB
Fusion gene ID: 37644
HgeneTgene
Gene symbol

HSD11B1L

SAFB

Gene ID

374875

6294

Gene namehydroxysteroid 11-beta dehydrogenase 1 likescaffold attachment factor B
Synonyms11-DH3|11-beta-HSD3|HSD1L|HSD3|SCDR10|SCDR10B|SDR26C2HAP|HET|SAB-B1|SAF-B|SAF-B1|SAFB1
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionhydroxysteroid 11-beta-dehydrogenase 1-like protein11-beta-hydroxysteroid dehydrogenase type 3short chain dehydrogenase/reductase 10short chain dehydrogenase/reductase family 26C member 2scaffold attachment factor B1HSP27 ERE-TATA-binding proteinHSP27 estrogen response element-TATA box-binding proteinHsp27 ERE-TATA binding proteinglutathione S-transferase fusion proteinheat-shock protein (HSP27) estrogen response element and TATA box
Modification date2020032020200313
UniProtAcc

Q7Z5J1

SLTM

Ensembl transtripts involved in fusion geneENST00000301382, ENST00000339423, 
ENST00000342970, ENST00000411793, 
ENST00000423665, ENST00000577917, 
ENST00000581521, ENST00000581773, 
ENST00000581893, ENST00000583928, 
ENST00000422535, ENST00000577701, 
ENST00000433404, ENST00000454510, 
ENST00000538656, ENST00000586934, 
ENST00000588852, ENST00000292123, 
ENST00000592224, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 7 X 5=245
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSD11B1L [Title/Abstract] AND SAFB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSD11B1L(5687679)-SAFB(5664033), # samples:2
SAFB(5626500)-HSD11B1L(5684829), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HSD11B1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SAFB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CR-7374-01AHSD11B1Lchr19

5687679

-SAFBchr19

5664033

+
ChimerDB4HNSCTCGA-CR-7374-01AHSD11B1Lchr19

5687679

+SAFBchr19

5664033

+


Top

Fusion Gene ORF analysis for HSD11B1L-SAFB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000301382ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000301382ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000301382ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000301382ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000301382ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000339423ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000339423ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000339423ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000339423ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000339423ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000342970ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000342970ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000342970ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000342970ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000342970ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000411793ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000411793ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000411793ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000411793ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000411793ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000423665ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000423665ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000423665ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000423665ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000423665ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000577917ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000577917ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000577917ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000577917ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000577917ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581521ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581521ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581521ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581521ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581521ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581773ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581773ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581773ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581773ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581773ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581893ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581893ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581893ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581893ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581893ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000583928ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000583928ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000583928ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000583928ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000583928ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000301382ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000301382ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000339423ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000339423ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000342970ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000342970ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000411793ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000411793ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000423665ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000423665ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000577917ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000577917ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000581521ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000581521ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000581773ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000581773ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000581893ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000581893ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000583928ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000583928ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-3CDSENST00000422535ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-3CDSENST00000422535ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-3CDSENST00000577701ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-3CDSENST00000577701ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000422535ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000422535ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000422535ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000422535ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000422535ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000577701ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000577701ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000577701ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000577701ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000577701ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for HSD11B1L-SAFB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HSD11B1Lchr195687679+SAFBchr195664032+2.04E-101
HSD11B1Lchr195687679+SAFBchr195664032+2.04E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for HSD11B1L-SAFB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5687679/chr19:5664033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSD11B1L

Q7Z5J1

SAFB

SLTM

1034

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000301382+56114_116141206.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000301382+5636_62141206.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000301382+5687_88141206.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000339423+78114_116222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000339423+78178_182222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000339423+78211_217222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000339423+7836_62222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000339423+7887_88222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000342970+67114_116135200.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000342970+6736_62135200.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000342970+6787_88135200.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000411793+5636_6288182.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000411793+5687_8888182.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000423665+78114_116222316.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000423665+78178_182222316.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000423665+78211_217222316.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000423665+7836_62222316.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000423665+7887_88222316.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000577917+56114_116141235.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000577917+5636_62141235.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000577917+5687_88141235.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581521+910114_116222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581521+910178_182222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581521+910211_217222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581521+91036_62222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581521+91087_88222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581773+89114_116222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581773+89178_182222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581773+89211_217222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581773+8936_62222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581773+8987_88222287.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581893+5636_6288153.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581893+5687_8888153.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000583928+4536_6288153.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000583928+4587_8888153.0Nucleotide bindingNADP
TgeneSAFBchr19:5687679chr19:5664033ENST000002921231421785_903717916.0Compositional biasNote=Gly-rich
TgeneSAFBchr19:5687679chr19:5664033ENST000004545101320785_903648849.0Compositional biasNote=Gly-rich
TgeneSAFBchr19:5687679chr19:5664033ENST000005888521421785_903717918.0Compositional biasNote=Gly-rich
TgeneSAFBchr19:5687679chr19:5664033ENST000005922241421785_903716917.0Compositional biasNote=Gly-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000301382+56178_182141206.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000301382+56211_217141206.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000342970+67178_182135200.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000342970+67211_217135200.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000411793+56114_11688182.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000411793+56178_18288182.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000411793+56211_21788182.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000422535+14114_116088.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000422535+14178_182088.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000422535+14211_217088.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000422535+1436_62088.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000422535+1487_88088.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000577917+56178_182141235.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000577917+56211_217141235.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581893+56114_11688153.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581893+56178_18288153.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581893+56211_21788153.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000583928+45114_11688153.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000583928+45178_18288153.0Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000583928+45211_21788153.0Nucleotide bindingNADP
TgeneSAFBchr19:5687679chr19:5664033ENST000002921231421612_831717916.0Compositional biasNote=Arg-rich
TgeneSAFBchr19:5687679chr19:5664033ENST000002921231421625_705717916.0Compositional biasNote=Glu-rich
TgeneSAFBchr19:5687679chr19:5664033ENST000004545101320612_831648849.0Compositional biasNote=Arg-rich
TgeneSAFBchr19:5687679chr19:5664033ENST000004545101320625_705648849.0Compositional biasNote=Glu-rich
TgeneSAFBchr19:5687679chr19:5664033ENST000005888521421612_831717918.0Compositional biasNote=Arg-rich
TgeneSAFBchr19:5687679chr19:5664033ENST000005888521421625_705717918.0Compositional biasNote=Glu-rich
TgeneSAFBchr19:5687679chr19:5664033ENST000005922241421612_831716917.0Compositional biasNote=Arg-rich
TgeneSAFBchr19:5687679chr19:5664033ENST000005922241421625_705716917.0Compositional biasNote=Glu-rich
TgeneSAFBchr19:5687679chr19:5664033ENST00000292123142131_65717916.0DomainSAP
TgeneSAFBchr19:5687679chr19:5664033ENST000002921231421406_484717916.0DomainRRM
TgeneSAFBchr19:5687679chr19:5664033ENST00000454510132031_65648849.0DomainSAP
TgeneSAFBchr19:5687679chr19:5664033ENST000004545101320406_484648849.0DomainRRM
TgeneSAFBchr19:5687679chr19:5664033ENST00000588852142131_65717918.0DomainSAP
TgeneSAFBchr19:5687679chr19:5664033ENST000005888521421406_484717918.0DomainRRM
TgeneSAFBchr19:5687679chr19:5664033ENST00000592224142131_65716917.0DomainSAP
TgeneSAFBchr19:5687679chr19:5664033ENST000005922241421406_484716917.0DomainRRM
TgeneSAFBchr19:5687679chr19:5664033ENST000002921231421599_616717916.0MotifNuclear localization signal
TgeneSAFBchr19:5687679chr19:5664033ENST000004545101320599_616648849.0MotifNuclear localization signal
TgeneSAFBchr19:5687679chr19:5664033ENST000005888521421599_616717918.0MotifNuclear localization signal
TgeneSAFBchr19:5687679chr19:5664033ENST000005922241421599_616716917.0MotifNuclear localization signal


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Fusion Gene Sequence for HSD11B1L-SAFB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HSD11B1L-SAFB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSAFBchr19:5687679chr19:5664033ENST000002921231421528_792717.6666666666666916.0POLR2A. Interaction with SFRS1%3B SFRS9 and SFRS10
TgeneSAFBchr19:5687679chr19:5664033ENST000004545101320528_792648.6666666666666849.0POLR2A. Interaction with SFRS1%3B SFRS9 and SFRS10
TgeneSAFBchr19:5687679chr19:5664033ENST000005888521421528_792717.6666666666666918.0POLR2A. Interaction with SFRS1%3B SFRS9 and SFRS10
TgeneSAFBchr19:5687679chr19:5664033ENST000005922241421528_792716.6666666666666917.0POLR2A. Interaction with SFRS1%3B SFRS9 and SFRS10
TgeneSAFBchr19:5687679chr19:5664033ENST000002921231421599_915717.6666666666666916.0SAFB2
TgeneSAFBchr19:5687679chr19:5664033ENST000004545101320599_915648.6666666666666849.0SAFB2
TgeneSAFBchr19:5687679chr19:5664033ENST000005888521421599_915717.6666666666666918.0SAFB2
TgeneSAFBchr19:5687679chr19:5664033ENST000005922241421599_915716.6666666666666917.0SAFB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSD11B1L-SAFB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HSD11B1L-SAFB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource