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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HSD17B11-UGT2A3 (FusionGDB2 ID:37654)

Fusion Gene Summary for HSD17B11-UGT2A3

check button Fusion gene summary
Fusion gene informationFusion gene name: HSD17B11-UGT2A3
Fusion gene ID: 37654
HgeneTgene
Gene symbol

HSD17B11

UGT2A3

Gene ID

51170

79799

Gene namehydroxysteroid 17-beta dehydrogenase 11UDP glucuronosyltransferase family 2 member A3
Synonyms17-BETA-HSD11|17-BETA-HSDXI|17BHSD11|DHRS8|PAN1B|RETSDR2|SDR16C2-
Cytomap

4q22.1

4q13.2

Type of geneprotein-codingprotein-coding
Descriptionestradiol 17-beta-dehydrogenase 1117-beta-hydroxysteroid dehydrogenase type XICTCL tumor antigen HD-CL-03CTCL-associated antigen HD-CL-03cutaneous T-cell lymphoma-associated antigen HD-CL-03dehydrogenase/reductase SDR family member 8retinal short-chUDP-glucuronosyltransferase 2A3UDP glucuronosyltransferase 2 family, polypeptide A3UDPGT 2A3
Modification date2020031320200313
UniProtAcc

Q8NBQ5

.
Ensembl transtripts involved in fusion geneENST00000358290, ENST00000507286, 
ENST00000507518, 		ENST00000420231, 
ENST00000251566, ENST00000547910, 
Fusion gene scores* DoF score5 X 6 X 3=904 X 4 X 3=48
# samples 87
** MAII scorelog2(8/90*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/48*10)=0.54432051622381
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HSD17B11 [Title/Abstract] AND UGT2A3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSD17B11(88312013)-UGT2A3(69798477), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSD17B11

GO:0006710

androgen catabolic process

12697717

TgeneUGT2A3

GO:0052695

cellular glucuronidation

19858781


check buttonFusion gene breakpoints across HSD17B11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UGT2A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BD-A2L6-01AHSD17B11chr4

88312013

-UGT2A3chr4

69796960

-
ChimerDB4LIHCTCGA-BD-A2L6-01AHSD17B11chr4

88312013

-UGT2A3chr4

69798477

-
ChimerDB4LIHCTCGA-BD-A2L6-01AHSD17B11chr4

88312013

-UGT2A3chr4_ctg9_hap1

510728

-
ChimerDB4LIHCTCGA-BD-A2L6HSD17B11chr4

88312012

-UGT2A3chr4

69798477

-


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Fusion Gene ORF analysis for HSD17B11-UGT2A3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000358290ENST00000420231HSD17B11chr4

88312013

-UGT2A3chr4

69798477

-
5CDS-5UTRENST00000358290ENST00000420231HSD17B11chr4

88312012

-UGT2A3chr4

69798477

-
5CDS-5UTRENST00000507286ENST00000420231HSD17B11chr4

88312013

-UGT2A3chr4

69798477

-
5CDS-5UTRENST00000507286ENST00000420231HSD17B11chr4

88312012

-UGT2A3chr4

69798477

-
5CDS-intronENST00000358290ENST00000251566HSD17B11chr4

88312013

-UGT2A3chr4_ctg9_hap1

510728

-
5CDS-intronENST00000358290ENST00000420231HSD17B11chr4

88312013

-UGT2A3chr4_ctg9_hap1

510728

-
5CDS-intronENST00000358290ENST00000547910HSD17B11chr4

88312013

-UGT2A3chr4

69796960

-
5CDS-intronENST00000358290ENST00000547910HSD17B11chr4

88312013

-UGT2A3chr4

69798477

-
5CDS-intronENST00000358290ENST00000547910HSD17B11chr4

88312013

-UGT2A3chr4_ctg9_hap1

510728

-
5CDS-intronENST00000358290ENST00000547910HSD17B11chr4

88312012

-UGT2A3chr4

69798477

-
5CDS-intronENST00000507286ENST00000251566HSD17B11chr4

88312013

-UGT2A3chr4_ctg9_hap1

510728

-
5CDS-intronENST00000507286ENST00000420231HSD17B11chr4

88312013

-UGT2A3chr4_ctg9_hap1

510728

-
5CDS-intronENST00000507286ENST00000547910HSD17B11chr4

88312013

-UGT2A3chr4

69796960

-
5CDS-intronENST00000507286ENST00000547910HSD17B11chr4

88312013

-UGT2A3chr4

69798477

-
5CDS-intronENST00000507286ENST00000547910HSD17B11chr4

88312013

-UGT2A3chr4_ctg9_hap1

510728

-
5CDS-intronENST00000507286ENST00000547910HSD17B11chr4

88312012

-UGT2A3chr4

69798477

-
In-frameENST00000358290ENST00000251566HSD17B11chr4

88312013

-UGT2A3chr4

69796960

-
In-frameENST00000358290ENST00000251566HSD17B11chr4

88312013

-UGT2A3chr4

69798477

-
In-frameENST00000358290ENST00000251566HSD17B11chr4

88312012

-UGT2A3chr4

69798477

-
In-frameENST00000358290ENST00000420231HSD17B11chr4

88312013

-UGT2A3chr4

69796960

-
In-frameENST00000507286ENST00000251566HSD17B11chr4

88312013

-UGT2A3chr4

69796960

-
In-frameENST00000507286ENST00000251566HSD17B11chr4

88312013

-UGT2A3chr4

69798477

-
In-frameENST00000507286ENST00000251566HSD17B11chr4

88312012

-UGT2A3chr4

69798477

-
In-frameENST00000507286ENST00000420231HSD17B11chr4

88312013

-UGT2A3chr4

69796960

-
intron-3CDSENST00000507518ENST00000251566HSD17B11chr4

88312013

-UGT2A3chr4

69796960

-
intron-3CDSENST00000507518ENST00000251566HSD17B11chr4

88312013

-UGT2A3chr4

69798477

-
intron-3CDSENST00000507518ENST00000251566HSD17B11chr4

88312012

-UGT2A3chr4

69798477

-
intron-3CDSENST00000507518ENST00000420231HSD17B11chr4

88312013

-UGT2A3chr4

69796960

-
intron-5UTRENST00000507518ENST00000420231HSD17B11chr4

88312013

-UGT2A3chr4

69798477

-
intron-5UTRENST00000507518ENST00000420231HSD17B11chr4

88312012

-UGT2A3chr4

69798477

-
intron-intronENST00000507518ENST00000251566HSD17B11chr4

88312013

-UGT2A3chr4_ctg9_hap1

510728

-
intron-intronENST00000507518ENST00000420231HSD17B11chr4

88312013

-UGT2A3chr4_ctg9_hap1

510728

-
intron-intronENST00000507518ENST00000547910HSD17B11chr4

88312013

-UGT2A3chr4

69796960

-
intron-intronENST00000507518ENST00000547910HSD17B11chr4

88312013

-UGT2A3chr4

69798477

-
intron-intronENST00000507518ENST00000547910HSD17B11chr4

88312013

-UGT2A3chr4_ctg9_hap1

510728

-
intron-intronENST00000507518ENST00000547910HSD17B11chr4

88312012

-UGT2A3chr4

69798477

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358290HSD17B11chr488312013-ENST00000251566UGT2A3chr469798477-25965263161245309
ENST00000507286HSD17B11chr488312013-ENST00000251566UGT2A3chr469798477-2359289791008309
ENST00000358290HSD17B11chr488312012-ENST00000251566UGT2A3chr469798477-25965263161245309
ENST00000507286HSD17B11chr488312012-ENST00000251566UGT2A3chr469798477-2359289791008309
ENST00000358290HSD17B11chr488312013-ENST00000251566UGT2A3chr469796960-24645263161113265
ENST00000358290HSD17B11chr488312013-ENST00000420231UGT2A3chr469796960-14705263161113265
ENST00000507286HSD17B11chr488312013-ENST00000251566UGT2A3chr469796960-222728979876265
ENST00000507286HSD17B11chr488312013-ENST00000420231UGT2A3chr469796960-123328979876265

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358290ENST00000251566HSD17B11chr488312013-UGT2A3chr469798477-0.0001799860.99982005
ENST00000507286ENST00000251566HSD17B11chr488312013-UGT2A3chr469798477-0.0001751840.9998248
ENST00000358290ENST00000251566HSD17B11chr488312012-UGT2A3chr469798477-0.0001799860.99982005
ENST00000507286ENST00000251566HSD17B11chr488312012-UGT2A3chr469798477-0.0001751840.9998248
ENST00000358290ENST00000251566HSD17B11chr488312013-UGT2A3chr469796960-0.0003735490.9996264
ENST00000358290ENST00000420231HSD17B11chr488312013-UGT2A3chr469796960-0.0008068390.99919313
ENST00000507286ENST00000251566HSD17B11chr488312013-UGT2A3chr469796960-0.0003935650.99960643
ENST00000507286ENST00000420231HSD17B11chr488312013-UGT2A3chr469796960-0.0007712220.99922884

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Fusion Genomic Features for HSD17B11-UGT2A3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HSD17B11-UGT2A3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:88312013/chr4:69798477)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSD17B11

Q8NBQ5

.
FUNCTION: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSD17B11chr4:88312012chr4:69798477ENST00000358290-1740_6470301.0Nucleotide bindingNADP
HgeneHSD17B11chr4:88312013chr4:69796960ENST00000358290-1740_6470301.0Nucleotide bindingNADP
HgeneHSD17B11chr4:88312013chr4:69798477ENST00000358290-1740_6470301.0Nucleotide bindingNADP
TgeneUGT2A3chr4:88312012chr4:69798477ENST0000025156616513_527288528.0Topological domainCytoplasmic
TgeneUGT2A3chr4:88312013chr4:69796960ENST0000025156626513_527332528.0Topological domainCytoplasmic
TgeneUGT2A3chr4:88312013chr4:69798477ENST0000025156616513_527288528.0Topological domainCytoplasmic
TgeneUGT2A3chr4:88312012chr4:69798477ENST0000025156616492_512288528.0TransmembraneHelical
TgeneUGT2A3chr4:88312013chr4:69796960ENST0000025156626492_512332528.0TransmembraneHelical
TgeneUGT2A3chr4:88312013chr4:69798477ENST0000025156616492_512288528.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUGT2A3chr4:88312012chr4:69798477ENST000002515661624_491288528.0Topological domainExtracellular
TgeneUGT2A3chr4:88312013chr4:69796960ENST000002515662624_491332528.0Topological domainExtracellular
TgeneUGT2A3chr4:88312013chr4:69798477ENST000002515661624_491288528.0Topological domainExtracellular


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Fusion Gene Sequence for HSD17B11-UGT2A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37654_37654_1_HSD17B11-UGT2A3_HSD17B11_chr4_88312012_ENST00000358290_UGT2A3_chr4_69798477_ENST00000251566_length(transcript)=2596nt_BP=526nt
TGGTGTAAAAGACAATCGCGGCCACACACCGCGTGGGGGCTGCGCAAAGCAGAACTAGGAAGCTTTGCTCCGGTCTGGACTTCGTCCCTC
CCAGATCTCTGAGCTAGCAAGCACTGCAGCCCGAGCCAATTGCGAAAGACCAACAAAGCCCAGCCCAGCGGAAGGAACGGTTTCGGAGTT
GTTTTTCTTTGATACGGGAGTTCCTCCTTGCTCTCGCCCCTACTCTTTCTGGTGTTAGATCGAGCTACCCTCTAAAAGCAGTTTAGAGTG
GTAAAAAAAAAAAAAAACACACCAAACGCTCGCAGCCACAAAAGGGATGAAATTTCTTCTGGACATCCTCCTGCTTCTCCCGTTACTGAT
CGTCTGCTCCCTAGAGTCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGTCACCGGCGAAATCGTGCTGATTACAGGAGCTGG
GCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAAAGCAAGCTGGTTCTCTGGGATATAAATAAGGAAATGGAAAATTT
TGTCCAGAGTTCAGGGGAAGATGGTATTGTGGTGTTTTCTCTGGGGTCACTGTTTCAAAATGTTACAGAAGAAAAGGCTAATATCATTGC
TTCAGCCCTTGCCCAGATCCCACAGAAGGTGTTATGGAGGTACAAAGGAAAAAAACCATCCACATTAGGAGCCAATACTCGGCTGTATGA
TTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAATGAATGGGATCTATGAAGCTATTTA
CCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTTGATAACATAGCTCACATGAAGGCCAAAGGAGCAGCTGTAGAAAT
AAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGAACAGTCATTACCGATTCCTCTTATAAAGAGAATGCTATGAGATT
ATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCAGTCTTCTGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCA
CCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCTATAGATGTGATTGGGTTCCTGCTGGCCTGTGTGGCAACTGCTAT
ATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAATAAAACTAGAAAGATAGAAAAGAGGGAATAGATCTTTCCAAATTC
AAGAAAGACCTGATGGGGTAATCCTGTTAATTCCAGCCACATAGAATTTGGTGAAAACCTTGCTATTTTCATATTATCTATTCTGTTATT
TTATCTTAGCTATATAGCCTAGAATTCCACGATCATGAGGTTGTGAGTATATCTCATTCTTTCGTTGTATTTTCCTAGGTGTCTTTACTC
TCTTCTCTCACTTTGTGACACAAGGACATGAATACATCTAAATTTTCCTATTTCTGATATGACTGTTTTGATGATGTCATTACTTCTATA
ACCTTAAGTGATAGGGTGACATGCAATATGATTATTCCTGGTGTGCGCCCAAACACATGGATATAAAGAGGTAAAAAACTTAAAATTCAC
AAAATTCAGTAAACCACACAAATCAGGTAAGTGTTCTATGAGATTAGCTGGCTATGAGAAACATAATGATGTTTCTTTTTCAATTTAAAT
AAGCCCTTCTACATAGCCAGCATCAGTGATCTCAGAAAATAAATTGCTAATAATGATGACATGGCATTATGCTTAGAAAAGTTTGCTGTA
TTTCCATAGACCTCATCTAGATGTCATGGCCTACATTTCTGCCATCACTCAACCAATACTTTTTTCTGTTTTCTTGATGATAAAAAGACC
TTTCTCATGATTGCCATCAAATAACAAAAGAAACTATTTTTTTTCTCACATAGAGAACATGTCAGTAAGATATTCAAGGTGAACAGATTA
TTTTTGGGATTAGTAACTATTTGAAATATGTGGTGATAATTACTGAGTTTATAAAATTTATTTGATAGTACACTTAAAGAAGATTTATAT
GTTTATTCTTTAAAAATGATGAATACTCATAATTCTTATCTCTATAATCAAAAGTATAATTTACTGTAGAAAAATAAAGAGATGCTTGTT
CTGAAAGTAAGATCAGTGAACTGCTTTTCAGTCTCAATCTTTGAGAATTGTAAATTCATCAAATAATTGCTTACATAGTAAAAATTTAAG
GTATTAGAAAACCTGCATAACAAATAGTATTATATATTAAATATTTTGATATGTAAAGCTCTACACAAAGCTAAATATAGTGTAATAATG
TTTACACTAATAAGCAAATATGTTAATCTTCTCATTTTTTTACTGTCATATAATCTTAGTGATATGCCTATTAATAGTTTTAAATAAATA
AATTGGCTCATCTGGCTTTTTGAAAATTTTGAAATTCTTACAGATGTTGATTAGGTATATCTACAAATTAATTTCAATTTTAAAATGATG

>37654_37654_1_HSD17B11-UGT2A3_HSD17B11_chr4_88312012_ENST00000358290_UGT2A3_chr4_69798477_ENST00000251566_length(amino acids)=309AA_BP=70
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKEMENFVQSSGEDGIVVFSLG
SLFQNVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQL
DNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYS

--------------------------------------------------------------
>37654_37654_2_HSD17B11-UGT2A3_HSD17B11_chr4_88312012_ENST00000507286_UGT2A3_chr4_69798477_ENST00000251566_length(transcript)=2359nt_BP=289nt
GATCGAGCTACCCTCTAAAAGCAGTTTAGAGTGGTAAAAAAAAAAAAAAACACACCAAACGCTCGCAGCCACAAAAGGGATGAAATTTCT
TCTGGACATCCTCCTGCTTCTCCCGTTACTGATCGTCTGCTCCCTAGAGTCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGT
CACCGGCGAAATCGTGCTGATTACAGGAGCTGGGCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAAAGCAAGCTGGT
TCTCTGGGATATAAATAAGGAAATGGAAAATTTTGTCCAGAGTTCAGGGGAAGATGGTATTGTGGTGTTTTCTCTGGGGTCACTGTTTCA
AAATGTTACAGAAGAAAAGGCTAATATCATTGCTTCAGCCCTTGCCCAGATCCCACAGAAGGTGTTATGGAGGTACAAAGGAAAAAAACC
ATCCACATTAGGAGCCAATACTCGGCTGTATGATTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCTTTTATCACTCA
TGGTGGAATGAATGGGATCTATGAAGCTATTTACCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTTGATAACATAGC
TCACATGAAGGCCAAAGGAGCAGCTGTAGAAATAAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGAACAGTCATTAC
CGATTCCTCTTATAAAGAGAATGCTATGAGATTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCAGTCTTCTGGAT
CGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCTATAGATGTGAT
TGGGTTCCTGCTGGCCTGTGTGGCAACTGCTATATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAATAAAACTAGAAA
GATAGAAAAGAGGGAATAGATCTTTCCAAATTCAAGAAAGACCTGATGGGGTAATCCTGTTAATTCCAGCCACATAGAATTTGGTGAAAA
CCTTGCTATTTTCATATTATCTATTCTGTTATTTTATCTTAGCTATATAGCCTAGAATTCCACGATCATGAGGTTGTGAGTATATCTCAT
TCTTTCGTTGTATTTTCCTAGGTGTCTTTACTCTCTTCTCTCACTTTGTGACACAAGGACATGAATACATCTAAATTTTCCTATTTCTGA
TATGACTGTTTTGATGATGTCATTACTTCTATAACCTTAAGTGATAGGGTGACATGCAATATGATTATTCCTGGTGTGCGCCCAAACACA
TGGATATAAAGAGGTAAAAAACTTAAAATTCACAAAATTCAGTAAACCACACAAATCAGGTAAGTGTTCTATGAGATTAGCTGGCTATGA
GAAACATAATGATGTTTCTTTTTCAATTTAAATAAGCCCTTCTACATAGCCAGCATCAGTGATCTCAGAAAATAAATTGCTAATAATGAT
GACATGGCATTATGCTTAGAAAAGTTTGCTGTATTTCCATAGACCTCATCTAGATGTCATGGCCTACATTTCTGCCATCACTCAACCAAT
ACTTTTTTCTGTTTTCTTGATGATAAAAAGACCTTTCTCATGATTGCCATCAAATAACAAAAGAAACTATTTTTTTTCTCACATAGAGAA
CATGTCAGTAAGATATTCAAGGTGAACAGATTATTTTTGGGATTAGTAACTATTTGAAATATGTGGTGATAATTACTGAGTTTATAAAAT
TTATTTGATAGTACACTTAAAGAAGATTTATATGTTTATTCTTTAAAAATGATGAATACTCATAATTCTTATCTCTATAATCAAAAGTAT
AATTTACTGTAGAAAAATAAAGAGATGCTTGTTCTGAAAGTAAGATCAGTGAACTGCTTTTCAGTCTCAATCTTTGAGAATTGTAAATTC
ATCAAATAATTGCTTACATAGTAAAAATTTAAGGTATTAGAAAACCTGCATAACAAATAGTATTATATATTAAATATTTTGATATGTAAA
GCTCTACACAAAGCTAAATATAGTGTAATAATGTTTACACTAATAAGCAAATATGTTAATCTTCTCATTTTTTTACTGTCATATAATCTT
AGTGATATGCCTATTAATAGTTTTAAATAAATAAATTGGCTCATCTGGCTTTTTGAAAATTTTGAAATTCTTACAGATGTTGATTAGGTA
TATCTACAAATTAATTTCAATTTTAAAATGATGATATAAAAATAAATATAAGTATTTTTCTTGTGTATGTATACAATAAATATAAATAAA

>37654_37654_2_HSD17B11-UGT2A3_HSD17B11_chr4_88312012_ENST00000507286_UGT2A3_chr4_69798477_ENST00000251566_length(amino acids)=309AA_BP=70
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKEMENFVQSSGEDGIVVFSLG
SLFQNVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQL
DNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYS

--------------------------------------------------------------
>37654_37654_3_HSD17B11-UGT2A3_HSD17B11_chr4_88312013_ENST00000358290_UGT2A3_chr4_69796960_ENST00000251566_length(transcript)=2464nt_BP=526nt
TGGTGTAAAAGACAATCGCGGCCACACACCGCGTGGGGGCTGCGCAAAGCAGAACTAGGAAGCTTTGCTCCGGTCTGGACTTCGTCCCTC
CCAGATCTCTGAGCTAGCAAGCACTGCAGCCCGAGCCAATTGCGAAAGACCAACAAAGCCCAGCCCAGCGGAAGGAACGGTTTCGGAGTT
GTTTTTCTTTGATACGGGAGTTCCTCCTTGCTCTCGCCCCTACTCTTTCTGGTGTTAGATCGAGCTACCCTCTAAAAGCAGTTTAGAGTG
GTAAAAAAAAAAAAAAACACACCAAACGCTCGCAGCCACAAAAGGGATGAAATTTCTTCTGGACATCCTCCTGCTTCTCCCGTTACTGAT
CGTCTGCTCCCTAGAGTCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGTCACCGGCGAAATCGTGCTGATTACAGGAGCTGG
GCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAAAGCAAGCTGGTTCTCTGGGATATAAATAAGGTGTTATGGAGGTA
CAAAGGAAAAAAACCATCCACATTAGGAGCCAATACTCGGCTGTATGATTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAA
AGCTTTTATCACTCATGGTGGAATGAATGGGATCTATGAAGCTATTTACCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCA
GCTTGATAACATAGCTCACATGAAGGCCAAAGGAGCAGCTGTAGAAATAAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTT
GAGAACAGTCATTACCGATTCCTCTTATAAAGAGAATGCTATGAGATTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCG
AGCAGTCTTCTGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTA
CTCTATAGATGTGATTGGGTTCCTGCTGGCCTGTGTGGCAACTGCTATATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATT
TAATAAAACTAGAAAGATAGAAAAGAGGGAATAGATCTTTCCAAATTCAAGAAAGACCTGATGGGGTAATCCTGTTAATTCCAGCCACAT
AGAATTTGGTGAAAACCTTGCTATTTTCATATTATCTATTCTGTTATTTTATCTTAGCTATATAGCCTAGAATTCCACGATCATGAGGTT
GTGAGTATATCTCATTCTTTCGTTGTATTTTCCTAGGTGTCTTTACTCTCTTCTCTCACTTTGTGACACAAGGACATGAATACATCTAAA
TTTTCCTATTTCTGATATGACTGTTTTGATGATGTCATTACTTCTATAACCTTAAGTGATAGGGTGACATGCAATATGATTATTCCTGGT
GTGCGCCCAAACACATGGATATAAAGAGGTAAAAAACTTAAAATTCACAAAATTCAGTAAACCACACAAATCAGGTAAGTGTTCTATGAG
ATTAGCTGGCTATGAGAAACATAATGATGTTTCTTTTTCAATTTAAATAAGCCCTTCTACATAGCCAGCATCAGTGATCTCAGAAAATAA
ATTGCTAATAATGATGACATGGCATTATGCTTAGAAAAGTTTGCTGTATTTCCATAGACCTCATCTAGATGTCATGGCCTACATTTCTGC
CATCACTCAACCAATACTTTTTTCTGTTTTCTTGATGATAAAAAGACCTTTCTCATGATTGCCATCAAATAACAAAAGAAACTATTTTTT
TTCTCACATAGAGAACATGTCAGTAAGATATTCAAGGTGAACAGATTATTTTTGGGATTAGTAACTATTTGAAATATGTGGTGATAATTA
CTGAGTTTATAAAATTTATTTGATAGTACACTTAAAGAAGATTTATATGTTTATTCTTTAAAAATGATGAATACTCATAATTCTTATCTC
TATAATCAAAAGTATAATTTACTGTAGAAAAATAAAGAGATGCTTGTTCTGAAAGTAAGATCAGTGAACTGCTTTTCAGTCTCAATCTTT
GAGAATTGTAAATTCATCAAATAATTGCTTACATAGTAAAAATTTAAGGTATTAGAAAACCTGCATAACAAATAGTATTATATATTAAAT
ATTTTGATATGTAAAGCTCTACACAAAGCTAAATATAGTGTAATAATGTTTACACTAATAAGCAAATATGTTAATCTTCTCATTTTTTTA
CTGTCATATAATCTTAGTGATATGCCTATTAATAGTTTTAAATAAATAAATTGGCTCATCTGGCTTTTTGAAAATTTTGAAATTCTTACA
GATGTTGATTAGGTATATCTACAAATTAATTTCAATTTTAAAATGATGATATAAAAATAAATATAAGTATTTTTCTTGTGTATGTATACA

>37654_37654_3_HSD17B11-UGT2A3_HSD17B11_chr4_88312013_ENST00000358290_UGT2A3_chr4_69796960_ENST00000251566_length(amino acids)=265AA_BP=98
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKVLWRYKGKKPSTLGANTRLY
DWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMR

--------------------------------------------------------------
>37654_37654_4_HSD17B11-UGT2A3_HSD17B11_chr4_88312013_ENST00000358290_UGT2A3_chr4_69796960_ENST00000420231_length(transcript)=1470nt_BP=526nt
TGGTGTAAAAGACAATCGCGGCCACACACCGCGTGGGGGCTGCGCAAAGCAGAACTAGGAAGCTTTGCTCCGGTCTGGACTTCGTCCCTC
CCAGATCTCTGAGCTAGCAAGCACTGCAGCCCGAGCCAATTGCGAAAGACCAACAAAGCCCAGCCCAGCGGAAGGAACGGTTTCGGAGTT
GTTTTTCTTTGATACGGGAGTTCCTCCTTGCTCTCGCCCCTACTCTTTCTGGTGTTAGATCGAGCTACCCTCTAAAAGCAGTTTAGAGTG
GTAAAAAAAAAAAAAAACACACCAAACGCTCGCAGCCACAAAAGGGATGAAATTTCTTCTGGACATCCTCCTGCTTCTCCCGTTACTGAT
CGTCTGCTCCCTAGAGTCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGTCACCGGCGAAATCGTGCTGATTACAGGAGCTGG
GCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAAAGCAAGCTGGTTCTCTGGGATATAAATAAGGTGTTATGGAGGTA
CAAAGGAAAAAAACCATCCACATTAGGAGCCAATACTCGGCTGTATGATTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAA
AGCTTTTATCACTCATGGTGGAATGAATGGGATCTATGAAGCTATTTACCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCA
GCTTGATAACATAGCTCACATGAAGGCCAAAGGAGCAGCTGTAGAAATAAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTT
GAGAACAGTCATTACCGATTCCTCTTATAAAGAGAATGCTATGAGATTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCG
AGCAGTCTTCTGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTA
CTCTATAGATGTGATTGGGTTCCTGCTGGCCTGTGTGGCAACTGCTATATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATT
TAATAAAACTAGAAAGATAGAAAAGAGGGAATAGATCTTTCCAAATTCAAGAAAGACCTGATGGGGTAATCCTGTTAATTCCAGCCACAT
AGAATTTGGTGAAAACCTTGCTATTTTCATATTATCTATTCTGTTATTTTATCTTAGCTATATAGCCTAGAATTCCACGATCATGAGGTT
GTGAGTATATCTCATTCTTTCGTTGTATTTTCCTAGGTGTCTTTACTCTCTTCTCTCACTTTGTGACACAAGGACATGAATACATCTAAA
TTTTCCTATTTCTGATATGACTGTTTTGATGATGTCATTACTTCTATAACCTTAAGTGATAGGGTGACATGCAATATGATTATTCCTGGT

>37654_37654_4_HSD17B11-UGT2A3_HSD17B11_chr4_88312013_ENST00000358290_UGT2A3_chr4_69796960_ENST00000420231_length(amino acids)=265AA_BP=98
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKVLWRYKGKKPSTLGANTRLY
DWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMR

--------------------------------------------------------------
>37654_37654_5_HSD17B11-UGT2A3_HSD17B11_chr4_88312013_ENST00000358290_UGT2A3_chr4_69798477_ENST00000251566_length(transcript)=2596nt_BP=526nt
TGGTGTAAAAGACAATCGCGGCCACACACCGCGTGGGGGCTGCGCAAAGCAGAACTAGGAAGCTTTGCTCCGGTCTGGACTTCGTCCCTC
CCAGATCTCTGAGCTAGCAAGCACTGCAGCCCGAGCCAATTGCGAAAGACCAACAAAGCCCAGCCCAGCGGAAGGAACGGTTTCGGAGTT
GTTTTTCTTTGATACGGGAGTTCCTCCTTGCTCTCGCCCCTACTCTTTCTGGTGTTAGATCGAGCTACCCTCTAAAAGCAGTTTAGAGTG
GTAAAAAAAAAAAAAAACACACCAAACGCTCGCAGCCACAAAAGGGATGAAATTTCTTCTGGACATCCTCCTGCTTCTCCCGTTACTGAT
CGTCTGCTCCCTAGAGTCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGTCACCGGCGAAATCGTGCTGATTACAGGAGCTGG
GCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAAAGCAAGCTGGTTCTCTGGGATATAAATAAGGAAATGGAAAATTT
TGTCCAGAGTTCAGGGGAAGATGGTATTGTGGTGTTTTCTCTGGGGTCACTGTTTCAAAATGTTACAGAAGAAAAGGCTAATATCATTGC
TTCAGCCCTTGCCCAGATCCCACAGAAGGTGTTATGGAGGTACAAAGGAAAAAAACCATCCACATTAGGAGCCAATACTCGGCTGTATGA
TTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAATGAATGGGATCTATGAAGCTATTTA
CCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTTGATAACATAGCTCACATGAAGGCCAAAGGAGCAGCTGTAGAAAT
AAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGAACAGTCATTACCGATTCCTCTTATAAAGAGAATGCTATGAGATT
ATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCAGTCTTCTGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCA
CCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCTATAGATGTGATTGGGTTCCTGCTGGCCTGTGTGGCAACTGCTAT
ATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAATAAAACTAGAAAGATAGAAAAGAGGGAATAGATCTTTCCAAATTC
AAGAAAGACCTGATGGGGTAATCCTGTTAATTCCAGCCACATAGAATTTGGTGAAAACCTTGCTATTTTCATATTATCTATTCTGTTATT
TTATCTTAGCTATATAGCCTAGAATTCCACGATCATGAGGTTGTGAGTATATCTCATTCTTTCGTTGTATTTTCCTAGGTGTCTTTACTC
TCTTCTCTCACTTTGTGACACAAGGACATGAATACATCTAAATTTTCCTATTTCTGATATGACTGTTTTGATGATGTCATTACTTCTATA
ACCTTAAGTGATAGGGTGACATGCAATATGATTATTCCTGGTGTGCGCCCAAACACATGGATATAAAGAGGTAAAAAACTTAAAATTCAC
AAAATTCAGTAAACCACACAAATCAGGTAAGTGTTCTATGAGATTAGCTGGCTATGAGAAACATAATGATGTTTCTTTTTCAATTTAAAT
AAGCCCTTCTACATAGCCAGCATCAGTGATCTCAGAAAATAAATTGCTAATAATGATGACATGGCATTATGCTTAGAAAAGTTTGCTGTA
TTTCCATAGACCTCATCTAGATGTCATGGCCTACATTTCTGCCATCACTCAACCAATACTTTTTTCTGTTTTCTTGATGATAAAAAGACC
TTTCTCATGATTGCCATCAAATAACAAAAGAAACTATTTTTTTTCTCACATAGAGAACATGTCAGTAAGATATTCAAGGTGAACAGATTA
TTTTTGGGATTAGTAACTATTTGAAATATGTGGTGATAATTACTGAGTTTATAAAATTTATTTGATAGTACACTTAAAGAAGATTTATAT
GTTTATTCTTTAAAAATGATGAATACTCATAATTCTTATCTCTATAATCAAAAGTATAATTTACTGTAGAAAAATAAAGAGATGCTTGTT
CTGAAAGTAAGATCAGTGAACTGCTTTTCAGTCTCAATCTTTGAGAATTGTAAATTCATCAAATAATTGCTTACATAGTAAAAATTTAAG
GTATTAGAAAACCTGCATAACAAATAGTATTATATATTAAATATTTTGATATGTAAAGCTCTACACAAAGCTAAATATAGTGTAATAATG
TTTACACTAATAAGCAAATATGTTAATCTTCTCATTTTTTTACTGTCATATAATCTTAGTGATATGCCTATTAATAGTTTTAAATAAATA
AATTGGCTCATCTGGCTTTTTGAAAATTTTGAAATTCTTACAGATGTTGATTAGGTATATCTACAAATTAATTTCAATTTTAAAATGATG

>37654_37654_5_HSD17B11-UGT2A3_HSD17B11_chr4_88312013_ENST00000358290_UGT2A3_chr4_69798477_ENST00000251566_length(amino acids)=309AA_BP=70
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKEMENFVQSSGEDGIVVFSLG
SLFQNVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQL
DNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYS

--------------------------------------------------------------
>37654_37654_6_HSD17B11-UGT2A3_HSD17B11_chr4_88312013_ENST00000507286_UGT2A3_chr4_69796960_ENST00000251566_length(transcript)=2227nt_BP=289nt
GATCGAGCTACCCTCTAAAAGCAGTTTAGAGTGGTAAAAAAAAAAAAAAACACACCAAACGCTCGCAGCCACAAAAGGGATGAAATTTCT
TCTGGACATCCTCCTGCTTCTCCCGTTACTGATCGTCTGCTCCCTAGAGTCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGT
CACCGGCGAAATCGTGCTGATTACAGGAGCTGGGCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAAAGCAAGCTGGT
TCTCTGGGATATAAATAAGGTGTTATGGAGGTACAAAGGAAAAAAACCATCCACATTAGGAGCCAATACTCGGCTGTATGATTGGATACC
CCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAATGAATGGGATCTATGAAGCTATTTACCATGGGGT
CCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTTGATAACATAGCTCACATGAAGGCCAAAGGAGCAGCTGTAGAAATAAACTTCAA
AACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGAACAGTCATTACCGATTCCTCTTATAAAGAGAATGCTATGAGATTATCAAGAAT
TCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCAGTCTTCTGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTGCGATC
AGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCTATAGATGTGATTGGGTTCCTGCTGGCCTGTGTGGCAACTGCTATATTCTTGTT
CACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAATAAAACTAGAAAGATAGAAAAGAGGGAATAGATCTTTCCAAATTCAAGAAAGAC
CTGATGGGGTAATCCTGTTAATTCCAGCCACATAGAATTTGGTGAAAACCTTGCTATTTTCATATTATCTATTCTGTTATTTTATCTTAG
CTATATAGCCTAGAATTCCACGATCATGAGGTTGTGAGTATATCTCATTCTTTCGTTGTATTTTCCTAGGTGTCTTTACTCTCTTCTCTC
ACTTTGTGACACAAGGACATGAATACATCTAAATTTTCCTATTTCTGATATGACTGTTTTGATGATGTCATTACTTCTATAACCTTAAGT
GATAGGGTGACATGCAATATGATTATTCCTGGTGTGCGCCCAAACACATGGATATAAAGAGGTAAAAAACTTAAAATTCACAAAATTCAG
TAAACCACACAAATCAGGTAAGTGTTCTATGAGATTAGCTGGCTATGAGAAACATAATGATGTTTCTTTTTCAATTTAAATAAGCCCTTC
TACATAGCCAGCATCAGTGATCTCAGAAAATAAATTGCTAATAATGATGACATGGCATTATGCTTAGAAAAGTTTGCTGTATTTCCATAG
ACCTCATCTAGATGTCATGGCCTACATTTCTGCCATCACTCAACCAATACTTTTTTCTGTTTTCTTGATGATAAAAAGACCTTTCTCATG
ATTGCCATCAAATAACAAAAGAAACTATTTTTTTTCTCACATAGAGAACATGTCAGTAAGATATTCAAGGTGAACAGATTATTTTTGGGA
TTAGTAACTATTTGAAATATGTGGTGATAATTACTGAGTTTATAAAATTTATTTGATAGTACACTTAAAGAAGATTTATATGTTTATTCT
TTAAAAATGATGAATACTCATAATTCTTATCTCTATAATCAAAAGTATAATTTACTGTAGAAAAATAAAGAGATGCTTGTTCTGAAAGTA
AGATCAGTGAACTGCTTTTCAGTCTCAATCTTTGAGAATTGTAAATTCATCAAATAATTGCTTACATAGTAAAAATTTAAGGTATTAGAA
AACCTGCATAACAAATAGTATTATATATTAAATATTTTGATATGTAAAGCTCTACACAAAGCTAAATATAGTGTAATAATGTTTACACTA
ATAAGCAAATATGTTAATCTTCTCATTTTTTTACTGTCATATAATCTTAGTGATATGCCTATTAATAGTTTTAAATAAATAAATTGGCTC
ATCTGGCTTTTTGAAAATTTTGAAATTCTTACAGATGTTGATTAGGTATATCTACAAATTAATTTCAATTTTAAAATGATGATATAAAAA

>37654_37654_6_HSD17B11-UGT2A3_HSD17B11_chr4_88312013_ENST00000507286_UGT2A3_chr4_69796960_ENST00000251566_length(amino acids)=265AA_BP=98
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKVLWRYKGKKPSTLGANTRLY
DWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMR

--------------------------------------------------------------
>37654_37654_7_HSD17B11-UGT2A3_HSD17B11_chr4_88312013_ENST00000507286_UGT2A3_chr4_69796960_ENST00000420231_length(transcript)=1233nt_BP=289nt
GATCGAGCTACCCTCTAAAAGCAGTTTAGAGTGGTAAAAAAAAAAAAAAACACACCAAACGCTCGCAGCCACAAAAGGGATGAAATTTCT
TCTGGACATCCTCCTGCTTCTCCCGTTACTGATCGTCTGCTCCCTAGAGTCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGT
CACCGGCGAAATCGTGCTGATTACAGGAGCTGGGCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAAAGCAAGCTGGT
TCTCTGGGATATAAATAAGGTGTTATGGAGGTACAAAGGAAAAAAACCATCCACATTAGGAGCCAATACTCGGCTGTATGATTGGATACC
CCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAATGAATGGGATCTATGAAGCTATTTACCATGGGGT
CCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTTGATAACATAGCTCACATGAAGGCCAAAGGAGCAGCTGTAGAAATAAACTTCAA
AACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGAACAGTCATTACCGATTCCTCTTATAAAGAGAATGCTATGAGATTATCAAGAAT
TCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCAGTCTTCTGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTGCGATC
AGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCTATAGATGTGATTGGGTTCCTGCTGGCCTGTGTGGCAACTGCTATATTCTTGTT
CACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAATAAAACTAGAAAGATAGAAAAGAGGGAATAGATCTTTCCAAATTCAAGAAAGAC
CTGATGGGGTAATCCTGTTAATTCCAGCCACATAGAATTTGGTGAAAACCTTGCTATTTTCATATTATCTATTCTGTTATTTTATCTTAG
CTATATAGCCTAGAATTCCACGATCATGAGGTTGTGAGTATATCTCATTCTTTCGTTGTATTTTCCTAGGTGTCTTTACTCTCTTCTCTC
ACTTTGTGACACAAGGACATGAATACATCTAAATTTTCCTATTTCTGATATGACTGTTTTGATGATGTCATTACTTCTATAACCTTAAGT

>37654_37654_7_HSD17B11-UGT2A3_HSD17B11_chr4_88312013_ENST00000507286_UGT2A3_chr4_69796960_ENST00000420231_length(amino acids)=265AA_BP=98
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKVLWRYKGKKPSTLGANTRLY
DWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMR

--------------------------------------------------------------
>37654_37654_8_HSD17B11-UGT2A3_HSD17B11_chr4_88312013_ENST00000507286_UGT2A3_chr4_69798477_ENST00000251566_length(transcript)=2359nt_BP=289nt
GATCGAGCTACCCTCTAAAAGCAGTTTAGAGTGGTAAAAAAAAAAAAAAACACACCAAACGCTCGCAGCCACAAAAGGGATGAAATTTCT
TCTGGACATCCTCCTGCTTCTCCCGTTACTGATCGTCTGCTCCCTAGAGTCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGT
CACCGGCGAAATCGTGCTGATTACAGGAGCTGGGCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAAAGCAAGCTGGT
TCTCTGGGATATAAATAAGGAAATGGAAAATTTTGTCCAGAGTTCAGGGGAAGATGGTATTGTGGTGTTTTCTCTGGGGTCACTGTTTCA
AAATGTTACAGAAGAAAAGGCTAATATCATTGCTTCAGCCCTTGCCCAGATCCCACAGAAGGTGTTATGGAGGTACAAAGGAAAAAAACC
ATCCACATTAGGAGCCAATACTCGGCTGTATGATTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCTTTTATCACTCA
TGGTGGAATGAATGGGATCTATGAAGCTATTTACCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTTGATAACATAGC
TCACATGAAGGCCAAAGGAGCAGCTGTAGAAATAAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGAACAGTCATTAC
CGATTCCTCTTATAAAGAGAATGCTATGAGATTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCAGTCTTCTGGAT
CGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCTATAGATGTGAT
TGGGTTCCTGCTGGCCTGTGTGGCAACTGCTATATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAATAAAACTAGAAA
GATAGAAAAGAGGGAATAGATCTTTCCAAATTCAAGAAAGACCTGATGGGGTAATCCTGTTAATTCCAGCCACATAGAATTTGGTGAAAA
CCTTGCTATTTTCATATTATCTATTCTGTTATTTTATCTTAGCTATATAGCCTAGAATTCCACGATCATGAGGTTGTGAGTATATCTCAT
TCTTTCGTTGTATTTTCCTAGGTGTCTTTACTCTCTTCTCTCACTTTGTGACACAAGGACATGAATACATCTAAATTTTCCTATTTCTGA
TATGACTGTTTTGATGATGTCATTACTTCTATAACCTTAAGTGATAGGGTGACATGCAATATGATTATTCCTGGTGTGCGCCCAAACACA
TGGATATAAAGAGGTAAAAAACTTAAAATTCACAAAATTCAGTAAACCACACAAATCAGGTAAGTGTTCTATGAGATTAGCTGGCTATGA
GAAACATAATGATGTTTCTTTTTCAATTTAAATAAGCCCTTCTACATAGCCAGCATCAGTGATCTCAGAAAATAAATTGCTAATAATGAT
GACATGGCATTATGCTTAGAAAAGTTTGCTGTATTTCCATAGACCTCATCTAGATGTCATGGCCTACATTTCTGCCATCACTCAACCAAT
ACTTTTTTCTGTTTTCTTGATGATAAAAAGACCTTTCTCATGATTGCCATCAAATAACAAAAGAAACTATTTTTTTTCTCACATAGAGAA
CATGTCAGTAAGATATTCAAGGTGAACAGATTATTTTTGGGATTAGTAACTATTTGAAATATGTGGTGATAATTACTGAGTTTATAAAAT
TTATTTGATAGTACACTTAAAGAAGATTTATATGTTTATTCTTTAAAAATGATGAATACTCATAATTCTTATCTCTATAATCAAAAGTAT
AATTTACTGTAGAAAAATAAAGAGATGCTTGTTCTGAAAGTAAGATCAGTGAACTGCTTTTCAGTCTCAATCTTTGAGAATTGTAAATTC
ATCAAATAATTGCTTACATAGTAAAAATTTAAGGTATTAGAAAACCTGCATAACAAATAGTATTATATATTAAATATTTTGATATGTAAA
GCTCTACACAAAGCTAAATATAGTGTAATAATGTTTACACTAATAAGCAAATATGTTAATCTTCTCATTTTTTTACTGTCATATAATCTT
AGTGATATGCCTATTAATAGTTTTAAATAAATAAATTGGCTCATCTGGCTTTTTGAAAATTTTGAAATTCTTACAGATGTTGATTAGGTA
TATCTACAAATTAATTTCAATTTTAAAATGATGATATAAAAATAAATATAAGTATTTTTCTTGTGTATGTATACAATAAATATAAATAAA

>37654_37654_8_HSD17B11-UGT2A3_HSD17B11_chr4_88312013_ENST00000507286_UGT2A3_chr4_69798477_ENST00000251566_length(amino acids)=309AA_BP=70
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKEMENFVQSSGEDGIVVFSLG
SLFQNVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQL
DNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HSD17B11-UGT2A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSD17B11-UGT2A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HSD17B11-UGT2A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource