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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HSD17B12-WT1 (FusionGDB2 ID:37666)

Fusion Gene Summary for HSD17B12-WT1

check button Fusion gene summary
Fusion gene informationFusion gene name: HSD17B12-WT1
Fusion gene ID: 37666
HgeneTgene
Gene symbol

HSD17B12

WT1

Gene ID

51144

7490

Gene namehydroxysteroid 17-beta dehydrogenase 12WT1 transcription factor
SynonymsKAR|SDR12C1AWT1|GUD|NPHS4|WAGR|WIT-2|WT33
Cytomap

11p11.2

11p13

Type of geneprotein-codingprotein-coding
Descriptionvery-long-chain 3-oxoacyl-CoA reductase17-beta-HSD 1217-beta-hydroxysteroid dehydrogenase 1217beta-HSD type 123-ketoacyl-CoA reductaseestradiol 17-beta-dehydrogenase 12short chain dehydrogenase/reductase family 12C member 1steroid dehydrogenase homWilms tumor proteinWilms tumor 1
Modification date2020031320200320
UniProtAcc

Q53GQ0

P19544

Ensembl transtripts involved in fusion geneENST00000278353, ENST00000395700, 
ENST00000529261, 		ENST00000332351, 
ENST00000379079, ENST00000448076, 
ENST00000530998, 
Fusion gene scores* DoF score13 X 13 X 7=11833 X 6 X 5=90
# samples 144
** MAII scorelog2(14/1183*10)=-3.07895134139482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/90*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSD17B12 [Title/Abstract] AND WT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSD17B12(43702537)-WT1(32450165), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWT1

GO:0000122

negative regulation of transcription by RNA polymerase II

7585606

TgeneWT1

GO:0007530

sex determination

9815658

TgeneWT1

GO:0008285

negative regulation of cell proliferation

9553041|9765217

TgeneWT1

GO:0030308

negative regulation of cell growth

9553041|9765217

TgeneWT1

GO:0045892

negative regulation of transcription, DNA-templated

1332065|7585606|7720589|8119964|12802290|14701728|19050011

TgeneWT1

GO:0045893

positive regulation of transcription, DNA-templated

8132626|9178767|9553041|9765217|12802290|14701728|16467207|21390327

TgeneWT1

GO:0045944

positive regulation of transcription by RNA polymerase II

23042785

TgeneWT1

GO:0071371

cellular response to gonadotropin stimulus

15961562


check buttonFusion gene breakpoints across HSD17B12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KICHTCGA-KL-8335-01AHSD17B12chr11

43702537

-WT1chr11

32450165

-
ChimerDB4KICHTCGA-KL-8335-01AHSD17B12chr11

43702537

+WT1chr11

32450165

-
ChimerDB4KICHTCGA-KL-8335HSD17B12chr11

43702537

+WT1chr11

32450165

-


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Fusion Gene ORF analysis for HSD17B12-WT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000278353ENST00000332351HSD17B12chr11

43702537

+WT1chr11

32450165

-
In-frameENST00000278353ENST00000379079HSD17B12chr11

43702537

+WT1chr11

32450165

-
In-frameENST00000278353ENST00000448076HSD17B12chr11

43702537

+WT1chr11

32450165

-
In-frameENST00000278353ENST00000530998HSD17B12chr11

43702537

+WT1chr11

32450165

-
In-frameENST00000395700ENST00000332351HSD17B12chr11

43702537

+WT1chr11

32450165

-
In-frameENST00000395700ENST00000379079HSD17B12chr11

43702537

+WT1chr11

32450165

-
In-frameENST00000395700ENST00000448076HSD17B12chr11

43702537

+WT1chr11

32450165

-
In-frameENST00000395700ENST00000530998HSD17B12chr11

43702537

+WT1chr11

32450165

-
intron-3CDSENST00000529261ENST00000332351HSD17B12chr11

43702537

+WT1chr11

32450165

-
intron-3CDSENST00000529261ENST00000379079HSD17B12chr11

43702537

+WT1chr11

32450165

-
intron-3CDSENST00000529261ENST00000448076HSD17B12chr11

43702537

+WT1chr11

32450165

-
intron-3CDSENST00000529261ENST00000530998HSD17B12chr11

43702537

+WT1chr11

32450165

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000278353HSD17B12chr1143702537+ENST00000379079WT1chr1132450165-24612791191177352
ENST00000278353HSD17B12chr1143702537+ENST00000332351WT1chr1132450165-24702791191186355
ENST00000278353HSD17B12chr1143702537+ENST00000530998WT1chr1132450165-24162791191135338
ENST00000278353HSD17B12chr1143702537+ENST00000448076WT1chr1132450165-15572791191177352
ENST00000395700HSD17B12chr1143702537+ENST00000379079WT1chr1132450165-2389207471105352
ENST00000395700HSD17B12chr1143702537+ENST00000332351WT1chr1132450165-2398207471114355
ENST00000395700HSD17B12chr1143702537+ENST00000530998WT1chr1132450165-2344207471063338
ENST00000395700HSD17B12chr1143702537+ENST00000448076WT1chr1132450165-1485207471105352

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000278353ENST00000379079HSD17B12chr1143702537+WT1chr1132450165-0.0152257390.98477423
ENST00000278353ENST00000332351HSD17B12chr1143702537+WT1chr1132450165-0.0151087370.98489124
ENST00000278353ENST00000530998HSD17B12chr1143702537+WT1chr1132450165-0.0090889060.99091107
ENST00000278353ENST00000448076HSD17B12chr1143702537+WT1chr1132450165-0.113835990.88616407
ENST00000395700ENST00000379079HSD17B12chr1143702537+WT1chr1132450165-0.0152350380.98476493
ENST00000395700ENST00000332351HSD17B12chr1143702537+WT1chr1132450165-0.0150019320.98499805
ENST00000395700ENST00000530998HSD17B12chr1143702537+WT1chr1132450165-0.0086302930.9913697
ENST00000395700ENST00000448076HSD17B12chr1143702537+WT1chr1132450165-0.1037109640.896289

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Fusion Genomic Features for HSD17B12-WT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HSD17B12-WT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:43702537/chr11:32450165)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSD17B12

Q53GQ0

WT1

P19544

FUNCTION: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16166196}.FUNCTION: Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). {ECO:0000269|PubMed:15520190, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17716689, ECO:0000269|PubMed:19123921, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:7862533}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSD17B12chr11:43702537chr11:32450165ENST00000278353+1114_2453313.0TransmembraneHelical
TgeneWT1chr11:43702537chr11:32450165ENST0000037907901027_833303.0Compositional biasNote=Pro-rich
TgeneWT1chr11:43702537chr11:32450165ENST000005309980927_833289.0Compositional biasNote=Pro-rich
TgeneWT1chr11:43702537chr11:32450165ENST00000379079010236_2443303.0Motif9aaTAD
TgeneWT1chr11:43702537chr11:32450165ENST0000053099809236_2443289.0Motif9aaTAD
TgeneWT1chr11:43702537chr11:32450165ENST00000379079010323_3473303.0Zinc fingerC2H2-type 1
TgeneWT1chr11:43702537chr11:32450165ENST00000379079010353_3773303.0Zinc fingerC2H2-type 2
TgeneWT1chr11:43702537chr11:32450165ENST00000379079010383_4053303.0Zinc fingerC2H2-type 3
TgeneWT1chr11:43702537chr11:32450165ENST00000379079010414_4383303.0Zinc fingerC2H2-type 4
TgeneWT1chr11:43702537chr11:32450165ENST0000053099809323_3473289.0Zinc fingerC2H2-type 1
TgeneWT1chr11:43702537chr11:32450165ENST0000053099809353_3773289.0Zinc fingerC2H2-type 2
TgeneWT1chr11:43702537chr11:32450165ENST0000053099809383_4053289.0Zinc fingerC2H2-type 3
TgeneWT1chr11:43702537chr11:32450165ENST0000053099809414_4383289.0Zinc fingerC2H2-type 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSD17B12chr11:43702537chr11:32450165ENST00000278353+111308_31253313.0MotifNote=Di-lysine motif
HgeneHSD17B12chr11:43702537chr11:32450165ENST00000278353+11150_7953313.0Nucleotide bindingNADP
HgeneHSD17B12chr11:43702537chr11:32450165ENST00000278353+111182_20253313.0TransmembraneHelical
HgeneHSD17B12chr11:43702537chr11:32450165ENST00000278353+111271_29153313.0TransmembraneHelical


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Fusion Gene Sequence for HSD17B12-WT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37666_37666_1_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000278353_WT1_chr11_32450165_ENST00000332351_length(transcript)=2470nt_BP=279nt
AAAGTGGTGTCGGAGCAGCGCCTATTAGTGTCATCCTCACCGTCACGGCCGGCGCCTCCTCCTGGATTCATTCACTCGCTCTTTTCATTC
ACGAAGGTAGTGAGGCCTAGTGGAAAGCCATGGAGAGCGCTCTCCCCGCCGCCGGCTTCCTGTACTGGGTCGGCGCGGGCACCGTGGCCT
ACCTAGCCCTGCGTATTTCGTACTCGCTCTTCACGGCCCTCCGGGTCTGGGGAGTGGGGAATGAGGCGGGGGTCGGCCCGGGGCTCGGAG
AATGGGCAGGTTACAGCACGGTCACCTTCGACGGGACGCCCAGCTACGGTCACACGCCCTCGCACCATGCGGCGCAGTTCCCCAACCACT
CATTCAAGCATGAGGATCCCATGGGCCAGCAGGGCTCGCTGGGTGAGCAGCAGTACTCGGTGCCGCCCCCGGTCTATGGCTGCCACACCC
CCACCGACAGCTGCACCGGCAGCCAGGCTTTGCTGCTGAGGACGCCCTACAGCAGTGACAATTTATACCAAATGACATCCCAGCTTGAAT
GCATGACCTGGAATCAGATGAACTTAGGAGCCACCTTAAAGGGAGTTGCTGCTGGGAGCTCCAGCTCAGTGAAATGGACAGAAGGGCAGA
GCAACCACAGCACAGGGTACGAGAGCGATAACCACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCA
GAGGCATTCAGGATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTGTACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGT
GTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGT
GTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCAAAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGT
GTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACAGGTAAAACAAGTGAAAAGCCCTTCA
GCTGTCGGTGGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAATTAGTCCGCCATCACAACATGCATCAGAGAAACATGACCAAAC
TCCAGCTGGCGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCA
CTCCTCCTCACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTG
CCTGGAAGAGTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGTCTGGTTAGTTAAAAGCCC
ATTGCCATTTGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGATCATGTCCCCCTGACCCTTCCCTTCTTTTTTTATGCTCGTTTT
CGCTGGGGATGGAATTATTGTACCATTTTCTATCATGGAATATTTATAGGCCAGGGCATGTGTATGTGTCTGCTAATGTAAACTTTGTCA
TGGTTTCCATTTACTAACAGCAACAGCAAGAAATAAATCAGAGAGCAAGGCATCGGGGGTGAATCTTGTCTAACATTCCCGAGGTCAGCC
AGGCTGCTAACCTGGAAAGCAGGATGTAGTTCTGCCAGGCAACTTTTAAAGCTCATGCATTTCAAGCAGCTGAAGAAAAAATCAGAACTA
ACCAGTACCTCTGTATAGAAATCTAAAAGAATTTTACCATTCAGTTAATTCAATGTGAACACTGGCACACTGCTCTTAAGAAACTATGAA
GATCTGAGATTTTTTTGTGTATGTTTTTGACTCTTTTGAGTGGTAATCATATGTGTCTTTATAGATGTACATACCTCCTTGCACAAATGG
AGGGGAATTCATTTTCATCACTGGGAGTGTCCTTAGTGTATAAAAACCATGCTGGTATATGGCTTCAAGTTGTAAAAATGAAAGTGACTT
TAAAAGAAAATAGGGGATGGTCCAGGATCTCCACTGATAAGACTGTTTTTAAGTAACTTAAGGACCTTTGGGTCTACAAGTATATGTGAA
AAAAATGAGACTTACTGGGTGAGGAAATCCATTGTTTAAAGATGGTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGTGTTGTG
TTTTGTTTTTTAAGGGAGGGAATTTATTATTTACCGTTGCTTGAAATTACTGTGTAAATATATGTCTGATAATGATTTGCTCTTTGACAA
CTAAAATTAGGACTGTATAAGTACTAGATGCATCACTGGGTGTTGATCTTACAAGATATTGATGATAACACTTAAAATTGTAACCTGCAT

>37666_37666_1_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000278353_WT1_chr11_32450165_ENST00000332351_length(amino acids)=355AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD
NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF

--------------------------------------------------------------
>37666_37666_2_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000278353_WT1_chr11_32450165_ENST00000379079_length(transcript)=2461nt_BP=279nt
AAAGTGGTGTCGGAGCAGCGCCTATTAGTGTCATCCTCACCGTCACGGCCGGCGCCTCCTCCTGGATTCATTCACTCGCTCTTTTCATTC
ACGAAGGTAGTGAGGCCTAGTGGAAAGCCATGGAGAGCGCTCTCCCCGCCGCCGGCTTCCTGTACTGGGTCGGCGCGGGCACCGTGGCCT
ACCTAGCCCTGCGTATTTCGTACTCGCTCTTCACGGCCCTCCGGGTCTGGGGAGTGGGGAATGAGGCGGGGGTCGGCCCGGGGCTCGGAG
AATGGGCAGGTTACAGCACGGTCACCTTCGACGGGACGCCCAGCTACGGTCACACGCCCTCGCACCATGCGGCGCAGTTCCCCAACCACT
CATTCAAGCATGAGGATCCCATGGGCCAGCAGGGCTCGCTGGGTGAGCAGCAGTACTCGGTGCCGCCCCCGGTCTATGGCTGCCACACCC
CCACCGACAGCTGCACCGGCAGCCAGGCTTTGCTGCTGAGGACGCCCTACAGCAGTGACAATTTATACCAAATGACATCCCAGCTTGAAT
GCATGACCTGGAATCAGATGAACTTAGGAGCCACCTTAAAGGGAGTTGCTGCTGGGAGCTCCAGCTCAGTGAAATGGACAGAAGGGCAGA
GCAACCACAGCACAGGGTACGAGAGCGATAACCACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCA
GAGGCATTCAGGATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTGTACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGT
GTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGT
GTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCAAAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGT
GTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACAGGTGAAAAGCCCTTCAGCTGTCGGT
GGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAATTAGTCCGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGG
CGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTC
ACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGA
GTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGCCATT
TGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGATCATGTCCCCCTGACCCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTGGGGA
TGGAATTATTGTACCATTTTCTATCATGGAATATTTATAGGCCAGGGCATGTGTATGTGTCTGCTAATGTAAACTTTGTCATGGTTTCCA
TTTACTAACAGCAACAGCAAGAAATAAATCAGAGAGCAAGGCATCGGGGGTGAATCTTGTCTAACATTCCCGAGGTCAGCCAGGCTGCTA
ACCTGGAAAGCAGGATGTAGTTCTGCCAGGCAACTTTTAAAGCTCATGCATTTCAAGCAGCTGAAGAAAAAATCAGAACTAACCAGTACC
TCTGTATAGAAATCTAAAAGAATTTTACCATTCAGTTAATTCAATGTGAACACTGGCACACTGCTCTTAAGAAACTATGAAGATCTGAGA
TTTTTTTGTGTATGTTTTTGACTCTTTTGAGTGGTAATCATATGTGTCTTTATAGATGTACATACCTCCTTGCACAAATGGAGGGGAATT
CATTTTCATCACTGGGAGTGTCCTTAGTGTATAAAAACCATGCTGGTATATGGCTTCAAGTTGTAAAAATGAAAGTGACTTTAAAAGAAA
ATAGGGGATGGTCCAGGATCTCCACTGATAAGACTGTTTTTAAGTAACTTAAGGACCTTTGGGTCTACAAGTATATGTGAAAAAAATGAG
ACTTACTGGGTGAGGAAATCCATTGTTTAAAGATGGTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGTGTTGTGTTTTGTTTT
TTAAGGGAGGGAATTTATTATTTACCGTTGCTTGAAATTACTGTGTAAATATATGTCTGATAATGATTTGCTCTTTGACAACTAAAATTA
GGACTGTATAAGTACTAGATGCATCACTGGGTGTTGATCTTACAAGATATTGATGATAACACTTAAAATTGTAACCTGCATTTTTCACTT

>37666_37666_2_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000278353_WT1_chr11_32450165_ENST00000379079_length(amino acids)=352AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD
NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF

--------------------------------------------------------------
>37666_37666_3_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000278353_WT1_chr11_32450165_ENST00000448076_length(transcript)=1557nt_BP=279nt
AAAGTGGTGTCGGAGCAGCGCCTATTAGTGTCATCCTCACCGTCACGGCCGGCGCCTCCTCCTGGATTCATTCACTCGCTCTTTTCATTC
ACGAAGGTAGTGAGGCCTAGTGGAAAGCCATGGAGAGCGCTCTCCCCGCCGCCGGCTTCCTGTACTGGGTCGGCGCGGGCACCGTGGCCT
ACCTAGCCCTGCGTATTTCGTACTCGCTCTTCACGGCCCTCCGGGTCTGGGGAGTGGGGAATGAGGCGGGGGTCGGCCCGGGGCTCGGAG
AATGGGCAGGTTACAGCACGGTCACCTTCGACGGGACGCCCAGCTACGGTCACACGCCCTCGCACCATGCGGCGCAGTTCCCCAACCACT
CATTCAAGCATGAGGATCCCATGGGCCAGCAGGGCTCGCTGGGTGAGCAGCAGTACTCGGTGCCGCCCCCGGTCTATGGCTGCCACACCC
CCACCGACAGCTGCACCGGCAGCCAGGCTTTGCTGCTGAGGACGCCCTACAGCAGTGACAATTTATACCAAATGACATCCCAGCTTGAAT
GCATGACCTGGAATCAGATGAACTTAGGAGCCACCTTAAAGGGAGTTGCTGCTGGGAGCTCCAGCTCAGTGAAATGGACAGAAGGGCAGA
GCAACCACAGCACAGGGTACGAGAGCGATAACCACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCA
GAGGCATTCAGGATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTGTACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGT
GTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGT
GTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCAAAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGT
GTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACAGGTGAAAAGCCCTTCAGCTGTCGGT
GGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAATTAGTCCGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGG
CGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTC
ACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGA
GTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGCCATT
TGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGATCATGTCCCCCTGACCCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTGGGGA

>37666_37666_3_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000278353_WT1_chr11_32450165_ENST00000448076_length(amino acids)=352AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD
NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF

--------------------------------------------------------------
>37666_37666_4_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000278353_WT1_chr11_32450165_ENST00000530998_length(transcript)=2416nt_BP=279nt
AAAGTGGTGTCGGAGCAGCGCCTATTAGTGTCATCCTCACCGTCACGGCCGGCGCCTCCTCCTGGATTCATTCACTCGCTCTTTTCATTC
ACGAAGGTAGTGAGGCCTAGTGGAAAGCCATGGAGAGCGCTCTCCCCGCCGCCGGCTTCCTGTACTGGGTCGGCGCGGGCACCGTGGCCT
ACCTAGCCCTGCGTATTTCGTACTCGCTCTTCACGGCCCTCCGGGTCTGGGGAGTGGGGAATGAGGCGGGGGTCGGCCCGGGGCTCGGAG
AATGGGCAGGTTACAGCACGGTCACCTTCGACGGGACGCCCAGCTACGGTCACACGCCCTCGCACCATGCGGCGCAGTTCCCCAACCACT
CATTCAAGCATGAGGATCCCATGGGCCAGCAGGGCTCGCTGGGTGAGCAGCAGTACTCGGTGCCGCCCCCGGTCTATGGCTGCCACACCC
CCACCGACAGCTGCACCGGCAGCCAGGCTTTGCTGCTGAGGACGCCCTACAGCAGTGACAATTTATACCAAATGACATCCCAGCTTGAAT
GCATGACCTGGAATCAGATGAACTTAGGAGCCACCTTAAAGGGCCACAGCACAGGGTACGAGAGCGATAACCACACAACGCCCATCCTCT
GCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTGTAC
GGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCCCACTTACAGA
TGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGTGTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCAAAA
GACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTGAAGACCCACA
CCAGGACTCATACAGGTAAAACAAGTGAAAAGCCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAATTAG
TCCGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGG
CAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTCACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACTTCC
AAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGAGTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGGCCC
TGGAGAAGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGCCATTTGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGATCAT
GTCCCCCTGACCCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTGGGGATGGAATTATTGTACCATTTTCTATCATGGAATATTTATAGGC
CAGGGCATGTGTATGTGTCTGCTAATGTAAACTTTGTCATGGTTTCCATTTACTAACAGCAACAGCAAGAAATAAATCAGAGAGCAAGGC
ATCGGGGGTGAATCTTGTCTAACATTCCCGAGGTCAGCCAGGCTGCTAACCTGGAAAGCAGGATGTAGTTCTGCCAGGCAACTTTTAAAG
CTCATGCATTTCAAGCAGCTGAAGAAAAAATCAGAACTAACCAGTACCTCTGTATAGAAATCTAAAAGAATTTTACCATTCAGTTAATTC
AATGTGAACACTGGCACACTGCTCTTAAGAAACTATGAAGATCTGAGATTTTTTTGTGTATGTTTTTGACTCTTTTGAGTGGTAATCATA
TGTGTCTTTATAGATGTACATACCTCCTTGCACAAATGGAGGGGAATTCATTTTCATCACTGGGAGTGTCCTTAGTGTATAAAAACCATG
CTGGTATATGGCTTCAAGTTGTAAAAATGAAAGTGACTTTAAAAGAAAATAGGGGATGGTCCAGGATCTCCACTGATAAGACTGTTTTTA
AGTAACTTAAGGACCTTTGGGTCTACAAGTATATGTGAAAAAAATGAGACTTACTGGGTGAGGAAATCCATTGTTTAAAGATGGTCGTGT
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGTGTTGTGTTTTGTTTTTTAAGGGAGGGAATTTATTATTTACCGTTGCTTGAAATTACT
GTGTAAATATATGTCTGATAATGATTTGCTCTTTGACAACTAAAATTAGGACTGTATAAGTACTAGATGCATCACTGGGTGTTGATCTTA

>37666_37666_4_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000278353_WT1_chr11_32450165_ENST00000530998_length(amino acids)=338AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGHSTGYESDNHTTPILCGAQYRIHTH
GVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVK

--------------------------------------------------------------
>37666_37666_5_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000395700_WT1_chr11_32450165_ENST00000332351_length(transcript)=2398nt_BP=207nt
CACTCGCTCTTTTCATTCACGAAGGTAGTGAGGCCTAGTGGAAAGCCATGGAGAGCGCTCTCCCCGCCGCCGGCTTCCTGTACTGGGTCG
GCGCGGGCACCGTGGCCTACCTAGCCCTGCGTATTTCGTACTCGCTCTTCACGGCCCTCCGGGTCTGGGGAGTGGGGAATGAGGCGGGGG
TCGGCCCGGGGCTCGGAGAATGGGCAGGTTACAGCACGGTCACCTTCGACGGGACGCCCAGCTACGGTCACACGCCCTCGCACCATGCGG
CGCAGTTCCCCAACCACTCATTCAAGCATGAGGATCCCATGGGCCAGCAGGGCTCGCTGGGTGAGCAGCAGTACTCGGTGCCGCCCCCGG
TCTATGGCTGCCACACCCCCACCGACAGCTGCACCGGCAGCCAGGCTTTGCTGCTGAGGACGCCCTACAGCAGTGACAATTTATACCAAA
TGACATCCCAGCTTGAATGCATGACCTGGAATCAGATGAACTTAGGAGCCACCTTAAAGGGAGTTGCTGCTGGGAGCTCCAGCTCAGTGA
AATGGACAGAAGGGCAGAGCAACCACAGCACAGGGTACGAGAGCGATAACCACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATAC
ACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTGTACGGTCGGCATCTGAGACCAGTG
AGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTG
GTGAGAAACCATACCAGTGTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCAAAAGACACCAAAGGAGACATACAG
GTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACAGGTAAAA
CAAGTGAAAAGCCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAATTAGTCCGCCATCACAACATGCATC
AGAGAAACATGACCAAACTCCAGCTGGCGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAGCACAGTGTGTGAACTGCT
TTCAAGTCTGACTCTCCACTCCTCCTCACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTC
TGGAAACTACCAGGTGTGCCTGGAAGAGTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGT
CTGGTTAGTTAAAAGCCCATTGCCATTTGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGATCATGTCCCCCTGACCCTTCCCTTC
TTTTTTTATGCTCGTTTTCGCTGGGGATGGAATTATTGTACCATTTTCTATCATGGAATATTTATAGGCCAGGGCATGTGTATGTGTCTG
CTAATGTAAACTTTGTCATGGTTTCCATTTACTAACAGCAACAGCAAGAAATAAATCAGAGAGCAAGGCATCGGGGGTGAATCTTGTCTA
ACATTCCCGAGGTCAGCCAGGCTGCTAACCTGGAAAGCAGGATGTAGTTCTGCCAGGCAACTTTTAAAGCTCATGCATTTCAAGCAGCTG
AAGAAAAAATCAGAACTAACCAGTACCTCTGTATAGAAATCTAAAAGAATTTTACCATTCAGTTAATTCAATGTGAACACTGGCACACTG
CTCTTAAGAAACTATGAAGATCTGAGATTTTTTTGTGTATGTTTTTGACTCTTTTGAGTGGTAATCATATGTGTCTTTATAGATGTACAT
ACCTCCTTGCACAAATGGAGGGGAATTCATTTTCATCACTGGGAGTGTCCTTAGTGTATAAAAACCATGCTGGTATATGGCTTCAAGTTG
TAAAAATGAAAGTGACTTTAAAAGAAAATAGGGGATGGTCCAGGATCTCCACTGATAAGACTGTTTTTAAGTAACTTAAGGACCTTTGGG
TCTACAAGTATATGTGAAAAAAATGAGACTTACTGGGTGAGGAAATCCATTGTTTAAAGATGGTCGTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTTGTGTTGTGTTTTGTTTTTTAAGGGAGGGAATTTATTATTTACCGTTGCTTGAAATTACTGTGTAAATATATGTCTGATAA
TGATTTGCTCTTTGACAACTAAAATTAGGACTGTATAAGTACTAGATGCATCACTGGGTGTTGATCTTACAAGATATTGATGATAACACT

>37666_37666_5_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000395700_WT1_chr11_32450165_ENST00000332351_length(amino acids)=355AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD
NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF

--------------------------------------------------------------
>37666_37666_6_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000395700_WT1_chr11_32450165_ENST00000379079_length(transcript)=2389nt_BP=207nt
CACTCGCTCTTTTCATTCACGAAGGTAGTGAGGCCTAGTGGAAAGCCATGGAGAGCGCTCTCCCCGCCGCCGGCTTCCTGTACTGGGTCG
GCGCGGGCACCGTGGCCTACCTAGCCCTGCGTATTTCGTACTCGCTCTTCACGGCCCTCCGGGTCTGGGGAGTGGGGAATGAGGCGGGGG
TCGGCCCGGGGCTCGGAGAATGGGCAGGTTACAGCACGGTCACCTTCGACGGGACGCCCAGCTACGGTCACACGCCCTCGCACCATGCGG
CGCAGTTCCCCAACCACTCATTCAAGCATGAGGATCCCATGGGCCAGCAGGGCTCGCTGGGTGAGCAGCAGTACTCGGTGCCGCCCCCGG
TCTATGGCTGCCACACCCCCACCGACAGCTGCACCGGCAGCCAGGCTTTGCTGCTGAGGACGCCCTACAGCAGTGACAATTTATACCAAA
TGACATCCCAGCTTGAATGCATGACCTGGAATCAGATGAACTTAGGAGCCACCTTAAAGGGAGTTGCTGCTGGGAGCTCCAGCTCAGTGA
AATGGACAGAAGGGCAGAGCAACCACAGCACAGGGTACGAGAGCGATAACCACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATAC
ACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTGTACGGTCGGCATCTGAGACCAGTG
AGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTG
GTGAGAAACCATACCAGTGTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCAAAAGACACCAAAGGAGACATACAG
GTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACAGGTGAAA
AGCCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAATTAGTCCGCCATCACAACATGCATCAGAGAAACA
TGACCAAACTCCAGCTGGCGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAGCACAGTGTGTGAACTGCTTTCAAGTCT
GACTCTCCACTCCTCCTCACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGGAAACTA
CCAGGTGTGCCTGGAAGAGTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGTCTGGTTAGT
TAAAAGCCCATTGCCATTTGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGATCATGTCCCCCTGACCCTTCCCTTCTTTTTTTAT
GCTCGTTTTCGCTGGGGATGGAATTATTGTACCATTTTCTATCATGGAATATTTATAGGCCAGGGCATGTGTATGTGTCTGCTAATGTAA
ACTTTGTCATGGTTTCCATTTACTAACAGCAACAGCAAGAAATAAATCAGAGAGCAAGGCATCGGGGGTGAATCTTGTCTAACATTCCCG
AGGTCAGCCAGGCTGCTAACCTGGAAAGCAGGATGTAGTTCTGCCAGGCAACTTTTAAAGCTCATGCATTTCAAGCAGCTGAAGAAAAAA
TCAGAACTAACCAGTACCTCTGTATAGAAATCTAAAAGAATTTTACCATTCAGTTAATTCAATGTGAACACTGGCACACTGCTCTTAAGA
AACTATGAAGATCTGAGATTTTTTTGTGTATGTTTTTGACTCTTTTGAGTGGTAATCATATGTGTCTTTATAGATGTACATACCTCCTTG
CACAAATGGAGGGGAATTCATTTTCATCACTGGGAGTGTCCTTAGTGTATAAAAACCATGCTGGTATATGGCTTCAAGTTGTAAAAATGA
AAGTGACTTTAAAAGAAAATAGGGGATGGTCCAGGATCTCCACTGATAAGACTGTTTTTAAGTAACTTAAGGACCTTTGGGTCTACAAGT
ATATGTGAAAAAAATGAGACTTACTGGGTGAGGAAATCCATTGTTTAAAGATGGTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
TGTGTTGTGTTTTGTTTTTTAAGGGAGGGAATTTATTATTTACCGTTGCTTGAAATTACTGTGTAAATATATGTCTGATAATGATTTGCT
CTTTGACAACTAAAATTAGGACTGTATAAGTACTAGATGCATCACTGGGTGTTGATCTTACAAGATATTGATGATAACACTTAAAATTGT

>37666_37666_6_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000395700_WT1_chr11_32450165_ENST00000379079_length(amino acids)=352AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD
NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF

--------------------------------------------------------------
>37666_37666_7_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000395700_WT1_chr11_32450165_ENST00000448076_length(transcript)=1485nt_BP=207nt
CACTCGCTCTTTTCATTCACGAAGGTAGTGAGGCCTAGTGGAAAGCCATGGAGAGCGCTCTCCCCGCCGCCGGCTTCCTGTACTGGGTCG
GCGCGGGCACCGTGGCCTACCTAGCCCTGCGTATTTCGTACTCGCTCTTCACGGCCCTCCGGGTCTGGGGAGTGGGGAATGAGGCGGGGG
TCGGCCCGGGGCTCGGAGAATGGGCAGGTTACAGCACGGTCACCTTCGACGGGACGCCCAGCTACGGTCACACGCCCTCGCACCATGCGG
CGCAGTTCCCCAACCACTCATTCAAGCATGAGGATCCCATGGGCCAGCAGGGCTCGCTGGGTGAGCAGCAGTACTCGGTGCCGCCCCCGG
TCTATGGCTGCCACACCCCCACCGACAGCTGCACCGGCAGCCAGGCTTTGCTGCTGAGGACGCCCTACAGCAGTGACAATTTATACCAAA
TGACATCCCAGCTTGAATGCATGACCTGGAATCAGATGAACTTAGGAGCCACCTTAAAGGGAGTTGCTGCTGGGAGCTCCAGCTCAGTGA
AATGGACAGAAGGGCAGAGCAACCACAGCACAGGGTACGAGAGCGATAACCACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATAC
ACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTGTACGGTCGGCATCTGAGACCAGTG
AGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTG
GTGAGAAACCATACCAGTGTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCAAAAGACACCAAAGGAGACATACAG
GTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACAGGTGAAA
AGCCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAATTAGTCCGCCATCACAACATGCATCAGAGAAACA
TGACCAAACTCCAGCTGGCGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAGCACAGTGTGTGAACTGCTTTCAAGTCT
GACTCTCCACTCCTCCTCACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGGAAACTA
CCAGGTGTGCCTGGAAGAGTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGTCTGGTTAGT
TAAAAGCCCATTGCCATTTGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGATCATGTCCCCCTGACCCTTCCCTTCTTTTTTTAT

>37666_37666_7_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000395700_WT1_chr11_32450165_ENST00000448076_length(amino acids)=352AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESD
NHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRF

--------------------------------------------------------------
>37666_37666_8_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000395700_WT1_chr11_32450165_ENST00000530998_length(transcript)=2344nt_BP=207nt
CACTCGCTCTTTTCATTCACGAAGGTAGTGAGGCCTAGTGGAAAGCCATGGAGAGCGCTCTCCCCGCCGCCGGCTTCCTGTACTGGGTCG
GCGCGGGCACCGTGGCCTACCTAGCCCTGCGTATTTCGTACTCGCTCTTCACGGCCCTCCGGGTCTGGGGAGTGGGGAATGAGGCGGGGG
TCGGCCCGGGGCTCGGAGAATGGGCAGGTTACAGCACGGTCACCTTCGACGGGACGCCCAGCTACGGTCACACGCCCTCGCACCATGCGG
CGCAGTTCCCCAACCACTCATTCAAGCATGAGGATCCCATGGGCCAGCAGGGCTCGCTGGGTGAGCAGCAGTACTCGGTGCCGCCCCCGG
TCTATGGCTGCCACACCCCCACCGACAGCTGCACCGGCAGCCAGGCTTTGCTGCTGAGGACGCCCTACAGCAGTGACAATTTATACCAAA
TGACATCCCAGCTTGAATGCATGACCTGGAATCAGATGAACTTAGGAGCCACCTTAAAGGGCCACAGCACAGGGTACGAGAGCGATAACC
ACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGCGACGTGTGCCTGGAG
TAGCCCCGACTCTTGTACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCAATAAGAGATATTTTA
AGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGTGTGACTTCAAGGACTGTGAACGAAGGTTTTCTC
GTTCAGACCAGCTCAAAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCG
ACCACCTGAAGACCCACACCAGGACTCATACAGGTAAAACAAGTGAAAAGCCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAAAGTTTG
CCCGGTCAGATGAATTAGTCCGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGAGGGGTCTCCCTCGGGG
ACCGTTCAGTGTCCCAGGCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTCACTAAAAAGGAAACTTCAGTTGAT
CTTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGAGTTGGTCTCTGCCCTGCCTACTTT
TAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGCCATTTGGTGTGGATTTTCTACTGTAAGA
AGAGCCATAGCTGATCATGTCCCCCTGACCCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTGGGGATGGAATTATTGTACCATTTTCTAT
CATGGAATATTTATAGGCCAGGGCATGTGTATGTGTCTGCTAATGTAAACTTTGTCATGGTTTCCATTTACTAACAGCAACAGCAAGAAA
TAAATCAGAGAGCAAGGCATCGGGGGTGAATCTTGTCTAACATTCCCGAGGTCAGCCAGGCTGCTAACCTGGAAAGCAGGATGTAGTTCT
GCCAGGCAACTTTTAAAGCTCATGCATTTCAAGCAGCTGAAGAAAAAATCAGAACTAACCAGTACCTCTGTATAGAAATCTAAAAGAATT
TTACCATTCAGTTAATTCAATGTGAACACTGGCACACTGCTCTTAAGAAACTATGAAGATCTGAGATTTTTTTGTGTATGTTTTTGACTC
TTTTGAGTGGTAATCATATGTGTCTTTATAGATGTACATACCTCCTTGCACAAATGGAGGGGAATTCATTTTCATCACTGGGAGTGTCCT
TAGTGTATAAAAACCATGCTGGTATATGGCTTCAAGTTGTAAAAATGAAAGTGACTTTAAAAGAAAATAGGGGATGGTCCAGGATCTCCA
CTGATAAGACTGTTTTTAAGTAACTTAAGGACCTTTGGGTCTACAAGTATATGTGAAAAAAATGAGACTTACTGGGTGAGGAAATCCATT
GTTTAAAGATGGTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGTGTTGTGTTTTGTTTTTTAAGGGAGGGAATTTATTATTTA
CCGTTGCTTGAAATTACTGTGTAAATATATGTCTGATAATGATTTGCTCTTTGACAACTAAAATTAGGACTGTATAAGTACTAGATGCAT
CACTGGGTGTTGATCTTACAAGATATTGATGATAACACTTAAAATTGTAACCTGCATTTTTCACTTTGCTCTCAATTAAAGTCTATTCAA

>37666_37666_8_HSD17B12-WT1_HSD17B12_chr11_43702537_ENST00000395700_WT1_chr11_32450165_ENST00000530998_length(amino acids)=338AA_BP=52
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQ
QGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGHSTGYESDNHTTPILCGAQYRIHTH
GVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HSD17B12-WT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSD17B12-WT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HSD17B12-WT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource