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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HSD17B3-CDC14B (FusionGDB2 ID:37673)

Fusion Gene Summary for HSD17B3-CDC14B

Fusion gene summary

Fusion gene information	Fusion gene name: HSD17B3-CDC14B
	Fusion gene ID: 37673
		Hgene	Tgene
	Gene symbol	HSD17B3	CDC14B
	Gene ID	3293	195828
	Gene name	hydroxysteroid 17-beta dehydrogenase 3	zinc finger protein 367
	Synonyms	EDH17B3\|SDR12C2	AFF29\|CDC14B\|ZFF29
	Cytomap	9q22.32	9q22.32\|9q22.32
	Type of gene	protein-coding	protein-coding
	Description	testosterone 17-beta-dehydrogenase 317-beta-HSD 317-beta-HSD317-beta-hydroxysteroid dehydrogenase type 3hydroxysteroid dehydrogenase 3short chain dehydrogenase/reductase family 12C member 2testicular 17-beta-hydroxysteroid dehydrogenase	zinc finger protein 367C2H2 zinc finger protein ZFF29C2H2 zinc finger protein ZFF29aCDC14 cell division cycle 14 homolog B
	Modification date	20200313	20200313
	UniProtAcc	P37058	O60729
	Ensembl transtripts involved in fusion gene	ENST00000375262, ENST00000375263, ENST00000464104,	ENST00000481149, ENST00000265659, ENST00000375236, ENST00000375240, ENST00000375241, ENST00000375242, ENST00000463569,
Fusion gene scores	* DoF score	4 X 3 X 3=36	7 X 7 X 4=196
	# samples	4	8
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HSD17B3 [Title/Abstract] AND CDC14B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HSD17B3(99060698)-CDC14B(99327765), # samples:1
Anticipated loss of major functional domain due to fusion event.	HSD17B3-CDC14B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CDC14B	GO:0006357	regulation of transcription by RNA polymerase II	15344908

Fusion gene breakpoints across HSD17B3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDC14B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-L4-A4E5-01A	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-

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Fusion Gene ORF analysis for HSD17B3-CDC14B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000375262	ENST00000481149	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
5CDS-intron	ENST00000375263	ENST00000481149	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
Frame-shift	ENST00000375262	ENST00000265659	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
Frame-shift	ENST00000375262	ENST00000375236	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
Frame-shift	ENST00000375262	ENST00000375240	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
Frame-shift	ENST00000375262	ENST00000375241	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
Frame-shift	ENST00000375262	ENST00000375242	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
Frame-shift	ENST00000375263	ENST00000265659	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
Frame-shift	ENST00000375263	ENST00000375236	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
Frame-shift	ENST00000375263	ENST00000375240	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
Frame-shift	ENST00000375263	ENST00000375241	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
Frame-shift	ENST00000375263	ENST00000375242	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
In-frame	ENST00000375262	ENST00000463569	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
In-frame	ENST00000375263	ENST00000463569	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
intron-3CDS	ENST00000464104	ENST00000265659	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
intron-3CDS	ENST00000464104	ENST00000375236	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
intron-3CDS	ENST00000464104	ENST00000375240	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
intron-3CDS	ENST00000464104	ENST00000375241	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
intron-3CDS	ENST00000464104	ENST00000375242	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
intron-3CDS	ENST00000464104	ENST00000463569	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-
intron-intron	ENST00000464104	ENST00000481149	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000375263	HSD17B3	chr9	99060698	-	ENST00000463569	CDC14B	chr9	99327765	-	1801	249	23	1546	507
ENST00000375262	HSD17B3	chr9	99060698	-	ENST00000463569	CDC14B	chr9	99327765	-	1753	201	56	1498	480

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375263	ENST00000463569	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-	0.001312561	0.99868745
ENST00000375262	ENST00000463569	HSD17B3	chr9	99060698	-	CDC14B	chr9	99327765	-	0.001295813	0.9987042

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Fusion Genomic Features for HSD17B3-CDC14B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HSD17B3-CDC14B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:99060698/chr9:99327765)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HSD17B3 P37058	CDC14B O60729
FUNCTION: Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH (PubMed:26545797, PubMed:8075637, PubMed:16216911). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911). {ECO:0000269\|PubMed:16216911, ECO:0000269\|PubMed:26545797, ECO:0000269\|PubMed:8075637}.	FUNCTION: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. {ECO:0000269\|PubMed:17488717, ECO:0000269\|PubMed:18662541, ECO:0000269\|PubMed:9367992}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000265659

214_374

472.0

Domain

Tyrosine-protein phosphatase

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375236

214_374

486.0

Domain

Tyrosine-protein phosphatase

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375240

214_374

460.0

Domain

Tyrosine-protein phosphatase

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375241

214_374

499.0

Domain

Tyrosine-protein phosphatase

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375242

214_374

462.0

Domain

Tyrosine-protein phosphatase

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000463569

214_374

518.0

Domain

Tyrosine-protein phosphatase

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000265659

199_212

472.0

Region

Note=Linker

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000265659

213_379

472.0

Region

Note=B

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375236

199_212

486.0

Region

Note=Linker

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375236

213_379

486.0

Region

Note=B

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375240

199_212

460.0

Region

Note=Linker

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375240

213_379

460.0

Region

Note=B

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375241

199_212

499.0

Region

Note=Linker

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375241

213_379

499.0

Region

Note=B

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375242

199_212

462.0

Region

Note=Linker

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375242

213_379

462.0

Region

Note=B

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375242

44_198

462.0

Region

Note=A

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000463569

199_212

518.0

Region

Note=Linker

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000463569

213_379

518.0

Region

Note=B

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HSD17B3

chr9:99060698

chr9:99327765

ENST00000375263

48_77

311.0

Nucleotide binding

NADP

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000265659

1_54

472.0

Motif

Nucleolar localization signal

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375236

1_54

486.0

Motif

Nucleolar localization signal

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375240

1_54

460.0

Motif

Nucleolar localization signal

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375241

1_54

499.0

Motif

Nucleolar localization signal

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375242

1_54

462.0

Motif

Nucleolar localization signal

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000463569

1_54

518.0

Motif

Nucleolar localization signal

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000265659

44_198

472.0

Region

Note=A

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375236

44_198

486.0

Region

Note=A

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375240

44_198

460.0

Region

Note=A

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000375241

44_198

499.0

Region

Note=A

Tgene

CDC14B

chr9:99060698

chr9:99327765

ENST00000463569

44_198

518.0

Region

Note=A

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Fusion Gene Sequence for HSD17B3-CDC14B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>37673_37673_1_HSD17B3-CDC14B_HSD17B3_chr9_99060698_ENST00000375262_CDC14B_chr9_99327765_ENST00000463569_length(transcript)=1753nt_BP=201nt
ATGGGGGACGTCCTGGAACAGTTCTTCATCCTCACAGGGCTGCTGGTGTGCCTGGCCTGCCTGGCGAAGTGCGTGAGATTCTCCAGATGT
GTTTTACTGAACTACTGGAAAGTTTTGCCAAAGTCTTTCTTGCGGTCAATGGGACAGTGGGCAGTGATCACTGGAGCAGGCGATGGAATT
GGGAAAGCGTACTCGTTCGAGATCGCCTTTGTTTTGCCATTCTCTACAGCAGACCAAAGAGTGCATCAAATGTACATTATTTCAGCATAG
ATAATGAACTTGAATATGAGAACTTCTACGCAGATTTTGGACCACTCAATCTGGCAATGGTTTACAGATATTGTTGCAAGATCAATAAGA
AATTAAAGTCCATTACAATGTTAAGGAAGAAAATTGTTCATTTTACTGGCTCTGATCAGAGAAAACAAGCAAATGCTGCCTTCCTTGTTG
GATGCTACATGGTTATATATTTGGGGAGAACCCCAGAAGAAGCATATAGAATATTAATCTTTGGAGAGACATCCTATATTCCTTTCAGAG
ATGCTGCCTATGGAAGTTGCAATTTCTACATTACACTTCTTGACTGTTTTCATGCAGTAAAGAAGGCAATGCAGTATGGCTTCCTTAATT
TCAACTCATTTAACCTTGATGAATATGAACACTATGAAAAAGCAGAAAATGGAGATTTAAATTGGATAATACCAGACCGATTTATTGCCT
TCTGTGGACCTCATTCAAGAGCCAGACTTGAAAGTGGTTACCACCAACATTCTCCTGAGACTTATATTCAATATTTTAAGAATCACAATG
TTACTACCATTATTCGTCTGAATAAAAGGATGTATGATGCCAAACGCTTTACGGATGCTGGCTTCGATCACCATGATCTTTTCTTTGCGG
ATGGCAGCACCCCTACTGATGCCATTGTCAAAGAATTCCTAGATATCTGTGAAAATGCTGAGGGTGCCATTGCAGTACATTGCAAAGCTG
GCCTTGGTCGCACGGGCACTCTGATAGCCTGCTACATCATGAAGCATTACAGGATGACAGCAGCCGAGACCATTGCGTGGGTCAGGATCT
GCAGACCTGGCTCGGTGATTGGGCCTCAGCAGCAGTTTTTGGTGATGAAGCAAACCAACCTCTGGCTGGAAGGGGACTATTTTCGTCAGA
AGTTAAAGGGGCAGGAGAATGGACAACACAGAGCAGCCTTCTCCAAACTTCTCTCTGGCGTTGATGACATTTCCATAAATGGGGTCGAGA
ATCAAGATCAGCAAGAACCCGAACCGTACAGTGATGATGACGAAATCAATGGAGTGACACAAGGTGATAGACTTCGGGCCTTGAAAAGCA
GAAGACAATCCAAAACAAACGCTATTCCTCTCACATGTCCCCTAGCTGTGCTGACCTCTGCACTGTGTAGTGTTGTCATCTGGTGGATTG
TTTGTGACTACATTCTTCCCATCCTGCTATTCTGTCTCGATGGTTTCAGAACACAGTAGCCATCAGGACCCCCTGACAGATAGCTGCTTC
TCTCCATTTCAAGGACTAAAACAGTCTTGCGTTAAGTAAAAACCTGTGACCAGAGCTGAAGGAAGACTCTAGGACTGAAAACTGCAACAG
AAATTAGCACAATTTGAAAACAAAACAAAATTGCAAAAGCCTTAGTTGCTTTTTCCACCTAAGAAGTTGATCAATGGAGAAAATGTCCAC

>37673_37673_1_HSD17B3-CDC14B_HSD17B3_chr9_99060698_ENST00000375262_CDC14B_chr9_99327765_ENST00000463569_length(amino acids)=480AA_BP=48
MPGEVREILQMCFTELLESFAKVFLAVNGTVGSDHWSRRWNWESVLVRDRLCFAILYSRPKSASNVHYFSIDNELEYENFYADFGPLNLA
MVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEEAYRILIFGETSYIPFRDAAYGSCNFYITLLDCFHA
VKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTD
AGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQT
NLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGVENQDQQEPEPYSDDDEINGVTQGDRLRALKSRRQSKTNAIPLTCPLAVLT

--------------------------------------------------------------
>37673_37673_2_HSD17B3-CDC14B_HSD17B3_chr9_99060698_ENST00000375263_CDC14B_chr9_99327765_ENST00000463569_length(transcript)=1801nt_BP=249nt
TACACAGAGAGCCACGGCCAGGGCTGAAACAGTCTGTTGAGTGCAGCCATGGGGGACGTCCTGGAACAGTTCTTCATCCTCACAGGGCTG
CTGGTGTGCCTGGCCTGCCTGGCGAAGTGCGTGAGATTCTCCAGATGTGTTTTACTGAACTACTGGAAAGTTTTGCCAAAGTCTTTCTTG
CGGTCAATGGGACAGTGGGCAGTGATCACTGGAGCAGGCGATGGAATTGGGAAAGCGTACTCGTTCGAGATCGCCTTTGTTTTGCCATTC
TCTACAGCAGACCAAAGAGTGCATCAAATGTACATTATTTCAGCATAGATAATGAACTTGAATATGAGAACTTCTACGCAGATTTTGGAC
CACTCAATCTGGCAATGGTTTACAGATATTGTTGCAAGATCAATAAGAAATTAAAGTCCATTACAATGTTAAGGAAGAAAATTGTTCATT
TTACTGGCTCTGATCAGAGAAAACAAGCAAATGCTGCCTTCCTTGTTGGATGCTACATGGTTATATATTTGGGGAGAACCCCAGAAGAAG
CATATAGAATATTAATCTTTGGAGAGACATCCTATATTCCTTTCAGAGATGCTGCCTATGGAAGTTGCAATTTCTACATTACACTTCTTG
ACTGTTTTCATGCAGTAAAGAAGGCAATGCAGTATGGCTTCCTTAATTTCAACTCATTTAACCTTGATGAATATGAACACTATGAAAAAG
CAGAAAATGGAGATTTAAATTGGATAATACCAGACCGATTTATTGCCTTCTGTGGACCTCATTCAAGAGCCAGACTTGAAAGTGGTTACC
ACCAACATTCTCCTGAGACTTATATTCAATATTTTAAGAATCACAATGTTACTACCATTATTCGTCTGAATAAAAGGATGTATGATGCCA
AACGCTTTACGGATGCTGGCTTCGATCACCATGATCTTTTCTTTGCGGATGGCAGCACCCCTACTGATGCCATTGTCAAAGAATTCCTAG
ATATCTGTGAAAATGCTGAGGGTGCCATTGCAGTACATTGCAAAGCTGGCCTTGGTCGCACGGGCACTCTGATAGCCTGCTACATCATGA
AGCATTACAGGATGACAGCAGCCGAGACCATTGCGTGGGTCAGGATCTGCAGACCTGGCTCGGTGATTGGGCCTCAGCAGCAGTTTTTGG
TGATGAAGCAAACCAACCTCTGGCTGGAAGGGGACTATTTTCGTCAGAAGTTAAAGGGGCAGGAGAATGGACAACACAGAGCAGCCTTCT
CCAAACTTCTCTCTGGCGTTGATGACATTTCCATAAATGGGGTCGAGAATCAAGATCAGCAAGAACCCGAACCGTACAGTGATGATGACG
AAATCAATGGAGTGACACAAGGTGATAGACTTCGGGCCTTGAAAAGCAGAAGACAATCCAAAACAAACGCTATTCCTCTCACATGTCCCC
TAGCTGTGCTGACCTCTGCACTGTGTAGTGTTGTCATCTGGTGGATTGTTTGTGACTACATTCTTCCCATCCTGCTATTCTGTCTCGATG
GTTTCAGAACACAGTAGCCATCAGGACCCCCTGACAGATAGCTGCTTCTCTCCATTTCAAGGACTAAAACAGTCTTGCGTTAAGTAAAAA
CCTGTGACCAGAGCTGAAGGAAGACTCTAGGACTGAAAACTGCAACAGAAATTAGCACAATTTGAAAACAAAACAAAATTGCAAAAGCCT
TAGTTGCTTTTTCCACCTAAGAAGTTGATCAATGGAGAAAATGTCCACTGGAGTTTGAATAATGAACTTTGAGTTTGGGTGCAAGCAAAT

>37673_37673_2_HSD17B3-CDC14B_HSD17B3_chr9_99060698_ENST00000375263_CDC14B_chr9_99327765_ENST00000463569_length(amino acids)=507AA_BP=75
MKQSVECSHGGRPGTVLHPHRAAGVPGLPGEVREILQMCFTELLESFAKVFLAVNGTVGSDHWSRRWNWESVLVRDRLCFAILYSRPKSA
SNVHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEEAYRILIFG
ETSYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPETY
IQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAA
ETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGVENQDQQEPEPYSDDDEINGVTQG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HSD17B3-CDC14B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HSD17B3-CDC14B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HSD17B3-CDC14B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source