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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HSP90AA1-PHTF2 (FusionGDB2 ID:37768)

Fusion Gene Summary for HSP90AA1-PHTF2

check button Fusion gene summary
Fusion gene informationFusion gene name: HSP90AA1-PHTF2
Fusion gene ID: 37768
HgeneTgene
Gene symbol

HSP90AA1

PHTF2

Gene ID

3320

57157

Gene nameheat shock protein 90 alpha family class A member 1putative homeodomain transcription factor 2
SynonymsEL52|HEL-S-65p|HSP86|HSP89A|HSP90A|HSP90N|HSPC1|HSPCA|HSPCAL1|HSPCAL4|HSPN|Hsp103|Hsp89|Hsp90|LAP-2|LAP2-
Cytomap

14q32.31

7q11.23-q21.11

Type of geneprotein-codingprotein-coding
Descriptionheat shock protein HSP 90-alphaHSP 86LPS-associated protein 2epididymis luminal secretory protein 52epididymis secretory sperm binding protein Li 65pheat shock 86 kDaheat shock 90kD protein 1, alphaheat shock 90kD protein 1, alpha-like 4heat shockputative homeodomain transcription factor 2
Modification date2020032720200313
UniProtAcc

P07900

.
Ensembl transtripts involved in fusion geneENST00000334701, ENST00000558600, 
ENST00000216281, ENST00000441629, 
ENST00000248550, ENST00000275575, 
ENST00000415251, ENST00000416283, 
ENST00000424760, ENST00000450574, 
ENST00000454592, ENST00000307305, 
ENST00000422959, 
Fusion gene scores* DoF score38 X 40 X 8=121607 X 7 X 8=392
# samples 4311
** MAII scorelog2(43/12160*10)=-4.82166275874149
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/392*10)=-1.83335013059055
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSP90AA1 [Title/Abstract] AND PHTF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSP90AA1(102605587)-PHTF2(77572017), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSP90AA1

GO:0001934

positive regulation of protein phosphorylation

19363271

HgeneHSP90AA1

GO:0007004

telomere maintenance via telomerase

10197982

HgeneHSP90AA1

GO:0031396

regulation of protein ubiquitination

16809764

HgeneHSP90AA1

GO:0032273

positive regulation of protein polymerization

19363271

HgeneHSP90AA1

GO:0045040

protein import into mitochondrial outer membrane

15644312

HgeneHSP90AA1

GO:0051131

chaperone-mediated protein complex assembly

15644312

HgeneHSP90AA1

GO:0051973

positive regulation of telomerase activity

10197982

HgeneHSP90AA1

GO:1902949

positive regulation of tau-protein kinase activity

19363271

HgeneHSP90AA1

GO:1905323

telomerase holoenzyme complex assembly

10197982


check buttonFusion gene breakpoints across HSP90AA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PHTF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GJ-01AHSP90AA1chr14

102605587

-PHTF2chr7

77572017

+


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Fusion Gene ORF analysis for HSP90AA1-PHTF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000334701ENST00000248550HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5CDS-intronENST00000334701ENST00000275575HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5CDS-intronENST00000334701ENST00000415251HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5CDS-intronENST00000334701ENST00000416283HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5CDS-intronENST00000334701ENST00000424760HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5CDS-intronENST00000334701ENST00000450574HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5CDS-intronENST00000334701ENST00000454592HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5UTR-3CDSENST00000558600ENST00000307305HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5UTR-3CDSENST00000558600ENST00000422959HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5UTR-intronENST00000558600ENST00000248550HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5UTR-intronENST00000558600ENST00000275575HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5UTR-intronENST00000558600ENST00000415251HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5UTR-intronENST00000558600ENST00000416283HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5UTR-intronENST00000558600ENST00000424760HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5UTR-intronENST00000558600ENST00000450574HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
5UTR-intronENST00000558600ENST00000454592HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
In-frameENST00000334701ENST00000307305HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
In-frameENST00000334701ENST00000422959HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-3CDSENST00000216281ENST00000307305HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-3CDSENST00000216281ENST00000422959HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-3CDSENST00000441629ENST00000307305HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-3CDSENST00000441629ENST00000422959HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000216281ENST00000248550HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000216281ENST00000275575HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000216281ENST00000415251HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000216281ENST00000416283HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000216281ENST00000424760HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000216281ENST00000450574HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000216281ENST00000454592HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000441629ENST00000248550HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000441629ENST00000275575HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000441629ENST00000415251HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000441629ENST00000416283HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000441629ENST00000424760HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000441629ENST00000450574HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+
intron-intronENST00000441629ENST00000454592HSP90AA1chr14

102605587

-PHTF2chr7

77572017

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334701HSP90AA1chr14102605587-ENST00000422959PHTF2chr777572017+1990437488922144
ENST00000334701HSP90AA1chr14102605587-ENST00000307305PHTF2chr777572017+3270437488922144

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334701ENST00000422959HSP90AA1chr14102605587-PHTF2chr777572017+0.66344620.33655378
ENST00000334701ENST00000307305HSP90AA1chr14102605587-PHTF2chr777572017+0.70976410.29023588

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Fusion Genomic Features for HSP90AA1-PHTF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HSP90AA1chr14102605586-PHTF2chr777572016+0.0002388560.99976116
HSP90AA1chr14102605586-PHTF2chr777572016+0.0002388560.99976116

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HSP90AA1-PHTF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:102605587/chr7:77572017)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSP90AA1

P07900

.
FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155, PubMed:12526792). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochodria outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePHTF2chr14:102605587chr7:77572017ENST000004152510946_1910353.0DomainPHTF
TgenePHTF2chr14:102605587chr7:77572017ENST000004505740946_1910357.0DomainPHTF
TgenePHTF2chr14:102605587chr7:77572017ENST000002485501319634_654624786.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000002485501319668_688624786.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000002485501319760_780624786.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000002755751217634_654586696.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000002755751217668_688586696.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000002755751217760_780586696.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000003073051218634_654586748.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000003073051218668_688586748.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000003073051218760_780586748.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000041525109136_1560353.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000041525109164_1840353.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000041525109497_5170353.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000041525109553_5730353.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000041525109634_6540353.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000041525109668_6880353.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000041525109760_7800353.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004162831218634_654590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004162831218668_688590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004162831218760_780590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004229591319634_654590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004229591319668_688590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004229591319760_780590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000045057409136_1560357.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000045057409164_1840357.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000045057409497_5170357.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000045057409553_5730357.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000045057409634_6540357.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000045057409668_6880357.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST0000045057409760_7800357.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000216281-111723_7320733.0MotifTPR repeat-binding
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000334701-112723_73251855.0MotifTPR repeat-binding
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000216281-111682_7320733.0RegionRequired for homodimerization
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000334701-112682_73251855.0RegionRequired for homodimerization
TgenePHTF2chr14:102605587chr7:77572017ENST00000248550131946_191624786.0DomainPHTF
TgenePHTF2chr14:102605587chr7:77572017ENST00000275575121746_191586696.0DomainPHTF
TgenePHTF2chr14:102605587chr7:77572017ENST00000307305121846_191586748.0DomainPHTF
TgenePHTF2chr14:102605587chr7:77572017ENST00000416283121846_191590752.0DomainPHTF
TgenePHTF2chr14:102605587chr7:77572017ENST00000422959131946_191590752.0DomainPHTF
TgenePHTF2chr14:102605587chr7:77572017ENST000002485501319136_156624786.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000002485501319164_184624786.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000002485501319497_517624786.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000002485501319553_573624786.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000002755751217136_156586696.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000002755751217164_184586696.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000002755751217497_517586696.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000002755751217553_573586696.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000003073051218136_156586748.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000003073051218164_184586748.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000003073051218497_517586748.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000003073051218553_573586748.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004162831218136_156590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004162831218164_184590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004162831218497_517590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004162831218553_573590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004229591319136_156590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004229591319164_184590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004229591319497_517590752.0TransmembraneHelical
TgenePHTF2chr14:102605587chr7:77572017ENST000004229591319553_573590752.0TransmembraneHelical


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Fusion Gene Sequence for HSP90AA1-PHTF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37768_37768_1_HSP90AA1-PHTF2_HSP90AA1_chr14_102605587_ENST00000334701_PHTF2_chr7_77572017_ENST00000307305_length(transcript)=3270nt_BP=437nt
GGGTGTGGCCTCCGGGCGGCATGGCTGCTTCCCAGGTGATGCCGGCTTCAGCTAGTGGGGTCTAGTTGACCGTTCCGCAGCCGCCAGGGC
CAGCGGAAAGCCGGTCAGGGGGAACCGCGGCGGGGCTGGTGTCATGAGCCTGAGGTGAACTTGAGGGTGCCTCCTCAGCGGTCTCCCGCC
CTGCCCTGAGGGGCGCCGGGACCCCAAAGAGCGGAGGAAGAGCGCCACCCCGACGGCCACCGCTTCGGAGCCAGCACGCGGGGTACCCTA
CGGGGAGCGCGGATGCCCCCGTGTTCGGGCGGGGACGGCTCCACCCCTCCTGGGCCCTCCCTTCGGGACAGGGACTGTCCCGCCCAGAGT
GCTGAATACCCGCGCGACCGTCTGGATCCCCGCCCAGGAAGCCCCTCTGAAGCCTCCTCGCCGCCGTTTCTGAGAAGCGTCGAGGTCCTC
AGCGATCAGTTGATGTAATAGTTTCATCTGCTTTCTTATTGACTATCTCAGTTGTATTTATCTGTTGTGCCCAGCTACTTCATGTACACG
AGATCTTCCTTGATTGTCACTACAATTGGGAATTGGTAATCTGGTGCATCTCGTTAACACTTTTTCTCCTAAGATTTGTTACCCTTGGAT
CAGAAACAAGTAAAAAATATAGTAATACCTCAATATTACTTACTGAACAGATAAACCTCTACTTGAAAATGGAGAAAAAACCTAACAAAA
AGGAGGAACTGACACTAGTGAATAATGTTTTAAAACTGGCTACTAAACTGCTAAAGGAGTTGGACAGTCCTTTTAGATTATATGGGCTTA
CAATGAATCCGCTGCTTTATAACATCACCCAGGTTGTTATCCTGTCAGCTGTTTCTGGTGTTATCAGTGACTTGCTTGGATTTAATTTAA
AGCTATGGAAGATTAAGTCATGACAATTCAAAGAAAAGAAGATGTAGCCTCTTTTCCAGAATAAGAGTACTGACTAAGCTGCCTGAAAGC
TTGTCACTGATTCTTTGCTTCAGGAGTCTCAGCTAGGGAGTTGAAGTGTTTACATCAGACTGTCTTGTGCAATTCTTATATTTATTTTAC
TGGTTCACTTTTTTTTACATTTATTTTAGTCTTTATATTTTTATTTTTAAGCATTGATGTACTTAGTTGTTGAAAGGGTGATGAAACTGA
TATCCAGATACTTGAGATCCTGGTAATTGGTCATAAATAATTGGCAAAATAACAAATTGTGAAAATAGAAGCCATTGCTCAGCACCGTTT
CTCCATCAATGCCGTGAACTTGCCTTACTTGAGGAAAAATTCTTTAACTTTGGAATATTGCATTGAACTCAGCTATACACATAAAACATT
TTCTTTGGTAAATCAAGATCCAGTCAGGGTTTCTCTTGAATTATTTTGGAACAATGCCAGGATCCAAACTGATTAAGTTACAGTTTAAGC
ACCCTTCAGTATTAATATATACGGTATTATATAACAGGTCAACAAGTGCTCTTTGATGATAAAACTTGTAATAGAGCAATAATTGTAAAT
GGTTACCATACTGTAAGATATTTTGATAAAAATTAACTAGTAATACTTGTATTTATTTGAAACACTGGGCTGTTTGCACAGCTCCAACTG
TGCATGCTCAAAATGTGCACTTTTTAAAATTGTTACTTTTAATGCGTATCTTTATATGGGATCTGTTATAGTATACTAGGGCATGATATG
GTATCCTTTTGAGTGAGGTATATACTCATCTCACAAGTGAAGTGCCTACTGATATTACTAAAGTACATTATGTTTACTCAAGTAAATAAT
TTTCTCCCCATGGTACACTCTAGTGTAGGCTATTCATACCACACTGAAATGAACAACTGAAGAATAAGGCTAAGAACCAATAAAATATTT
CTCTAATTGCTAGTTGTAAAACTGTATCCAAATTTTCAGAAAAGACAGCTTCAGCTTGCAAATTCTATCCTCTAAACTTATCTGGTGCAT
TCTCCCCACCCCACCCCCATTATATAAGGGCTATTTTAGATGCTTTTAACCTCCCCAACAAATAATTTGCCAAGTGTCCAATGAGAACTT
ATCATGTTGGTGTGTTAGGTAAATCGGGCAAATATGATAGTGTCTTACATTGGGCCTTGATTTTAAGTTGTTATATTTGTACAATCGAGT
ATTTTAGAAATTACATGAAACATGAAACAGTTTTTGCAATTTTTTTTAAACTGGGCATCTGGTTTCTAAAAATTTATTTGAAACAATCTA
GAATTTTCTTGGTGCAAAGTGTATCATGTGGAATATCCTCATATTTTTACCATATTTTAAGAACTTTAAGACGATTAATTGTAAATAATT
TATTTGATTGGTGCAGTTCTAATCCCTAAATCATAATCTTAAAATCAGGAATGTGTGGAGAACAGAGCCATGTCATATCACTTTGCTCTT
ACCATTCCTTTTGATCAGCCTCAATTCAGCCTCATTGTGTAGTATGTTTTTTCTTTCTATGAAAAACAACAGAAAGCATTTCATTTTATT
TGCCTATGTTCAAATATGTTTAATAATGACCAAAGTGCATTCTGAGTTTTTTCAAGGAATGTAATACTGGAGCTTTAAGAACATACTTAG
TTTCTCATGTGAAAACTTAGGCTTTGTCTGATGTTTTTCCTTCCTCTATTGTCTAATGTTGAGGTTGTTTTTAGGAATTATGTTTTATAA
ACTTTTTCAATATAAGGTACATGCCTATACAGAACTTAACATTTTGCACAGAATATATCAAATATATTTTGAGAAAAAAAGTACGGCATG
AGTTCTGTTAGGAATAAAAGATGAAACTATTGTATCTCACAAAAAATCTTATTTCAGAATGGAAATATTTTTGAGAAAAGTAGCTGAGTA
TACTGGTTTAAGAAAATGCTTGTTTTAGATTGAGGTTAACTTAGAGTTGGGAGTTGATTTATTAAGTACAGTATACCTCTCAACAGTTTA
TAAATAATATGTTGAATTATGTCAGTGTGGGCAGCAGTAGAATACTAAAAGGAAAATGTCATGTTAAGCAATTTCAGAACATTAACTGAA
CTATTTTCAAAGCAGAAAAATTGACATTGCTGCCTTTAAGAATACCATGAATGTAAGAAATTGAAAGAAATTGTAAAATATCACATAATA
TAGAAATGGCAGTTCAAAGAGAATTGTGGCAGATGTTGTGTGTGAACTGTTGTTTCTTTGCCACATGTGTTGTATTTGAAAGTTTTACAG

>37768_37768_1_HSP90AA1-PHTF2_HSP90AA1_chr14_102605587_ENST00000334701_PHTF2_chr7_77572017_ENST00000307305_length(amino acids)=144AA_BP=
MTISVVFICCAQLLHVHEIFLDCHYNWELVIWCISLTLFLLRFVTLGSETSKKYSNTSILLTEQINLYLKMEKKPNKKEELTLVNNVLKL

--------------------------------------------------------------
>37768_37768_2_HSP90AA1-PHTF2_HSP90AA1_chr14_102605587_ENST00000334701_PHTF2_chr7_77572017_ENST00000422959_length(transcript)=1990nt_BP=437nt
GGGTGTGGCCTCCGGGCGGCATGGCTGCTTCCCAGGTGATGCCGGCTTCAGCTAGTGGGGTCTAGTTGACCGTTCCGCAGCCGCCAGGGC
CAGCGGAAAGCCGGTCAGGGGGAACCGCGGCGGGGCTGGTGTCATGAGCCTGAGGTGAACTTGAGGGTGCCTCCTCAGCGGTCTCCCGCC
CTGCCCTGAGGGGCGCCGGGACCCCAAAGAGCGGAGGAAGAGCGCCACCCCGACGGCCACCGCTTCGGAGCCAGCACGCGGGGTACCCTA
CGGGGAGCGCGGATGCCCCCGTGTTCGGGCGGGGACGGCTCCACCCCTCCTGGGCCCTCCCTTCGGGACAGGGACTGTCCCGCCCAGAGT
GCTGAATACCCGCGCGACCGTCTGGATCCCCGCCCAGGAAGCCCCTCTGAAGCCTCCTCGCCGCCGTTTCTGAGAAGCGTCGAGGTCCTC
AGCGATCAGTTGATGTAATAGTTTCATCTGCTTTCTTATTGACTATCTCAGTTGTATTTATCTGTTGTGCCCAGCTACTTCATGTACACG
AGATCTTCCTTGATTGTCACTACAATTGGGAATTGGTAATCTGGTGCATCTCGTTAACACTTTTTCTCCTAAGATTTGTTACCCTTGGAT
CAGAAACAAGTAAAAAATATAGTAATACCTCAATATTACTTACTGAACAGATAAACCTCTACTTGAAAATGGAGAAAAAACCTAACAAAA
AGGAGGAACTGACACTAGTGAATAATGTTTTAAAACTGGCTACTAAACTGCTAAAGGAGTTGGACAGTCCTTTTAGATTATATGGGCTTA
CAATGAATCCGCTGCTTTATAACATCACCCAGGTTGTTATCCTGTCAGCTGTTTCTGGTGTTATCAGTGACTTGCTTGGATTTAATTTAA
AGCTATGGAAGATTAAGTCATGACAATTCAAAGAAAAGAAGATGTAGCCTCTTTTCCAGAATAAGAGTACTGACTAAGCTGCCTGAAAGC
TTGTCACTGATTCTTTGCTTCAGGAGTCTCAGCTAGGGAGTTGAAGTGTTTACATCAGACTGTCTTGTGCAATTCTTATATTTATTTTAC
TGGTTCACTTTTTTTTACATTTATTTTAGTCTTTATATTTTTATTTTTAAGCATTGATGTACTTAGTTGTTGAAAGGGTGATGAAACTGA
TATCCAGATACTTGAGATCCTGGTAATTGGTCATAAATAATTGGCAAAATAACAAATTGTGAAAATAGAAGCCATTGCTCAGCACCGTTT
CTCCATCAATGCCGTGAACTTGCCTTACTTGAGGAAAAATTCTTTAACTTTGGAATATTGCATTGAACTCAGCTATACACATAAAACATT
TTCTTTGGTAAATCAAGATCCAGTCAGGGTTTCTCTTGAATTATTTTGGAACAATGCCAGGATCCAAACTGATTAAGTTACAGTTTAAGC
ACCCTTCAGTATTAATATATACGGTATTATATAACAGGTCAACAAGTGCTCTTTGATGATAAAACTTGTAATAGAGCAATAATTGTAAAT
GGTTACCATACTGTAAGATATTTTGATAAAAATTAACTAGTAATACTTGTATTTATTTGAAACACTGGGCTGTTTGCACAGCTCCAACTG
TGCATGCTCAAAATGTGCACTTTTTAAAATTGTTACTTTTAATGCGTATCTTTATATGGGATCTGTTATAGTATACTAGGGCATGATATG
GTATCCTTTTGAGTGAGGTATATACTCATCTCACAAGTGAAGTGCCTACTGATATTACTAAAGTACATTATGTTTACTCAAGTAAATAAT
TTTCTCCCCATGGTACACTCTAGTGTAGGCTATTCATACCACACTGAAATGAACAACTGAAGAATAAGGCTAAGAACCAATAAAATATTT
CTCTAATTGCTAGTTGTAAAACTGTATCCAAATTTTCAGAAAAGACAGCTTCAGCTTGCAAATTCTATCCTCTAAACTTATCTGGTGCAT

>37768_37768_2_HSP90AA1-PHTF2_HSP90AA1_chr14_102605587_ENST00000334701_PHTF2_chr7_77572017_ENST00000422959_length(amino acids)=144AA_BP=
MTISVVFICCAQLLHVHEIFLDCHYNWELVIWCISLTLFLLRFVTLGSETSKKYSNTSILLTEQINLYLKMEKKPNKKEELTLVNNVLKL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HSP90AA1-PHTF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000216281-111284_7320733.0FLCN and FNIP1
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000334701-112284_73251.666666666666664855.0FLCN and FNIP1
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000216281-111284_6200733.0FNIP2 and TSC1
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000334701-112284_62051.666666666666664855.0FNIP2 and TSC1
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000216281-111628_7310733.0NR1D1
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000334701-112628_73151.666666666666664855.0NR1D1
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000216281-111271_6160733.0NR3C1
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000216281-1119_2360733.0NR3C1
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000334701-112271_61651.666666666666664855.0NR3C1
HgeneHSP90AA1chr14:102605587chr7:77572017ENST00000334701-1129_23651.666666666666664855.0NR3C1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSP90AA1-PHTF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HSP90AA1-PHTF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource