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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HSP90AB1-MKL2 (FusionGDB2 ID:37802)

Fusion Gene Summary for HSP90AB1-MKL2

check button Fusion gene summary
Fusion gene informationFusion gene name: HSP90AB1-MKL2
Fusion gene ID: 37802
HgeneTgene
Gene symbol

HSP90AB1

MKL2

Gene ID

3326

57496

Gene nameheat shock protein 90 alpha family class B member 1myocardin related transcription factor B
SynonymsD6S182|HSP84|HSP90B|HSPC2|HSPCBMKL2|MRTF-B|NPD001
Cytomap

6p21.1

16p13.12

Type of geneprotein-codingprotein-coding
Descriptionheat shock protein HSP 90-betaHSP90-betaheat shock 84 kDaheat shock 90kD protein 1, betaheat shock protein 90 kDaheat shock protein 90kDa alpha (cytosolic), class B member 1heat shock protein 90kDa alpha family class B member 1myocardin-related transcription factor BCTA-276F8.1MKL and myocardin family member 2MKL/myocardin like 2MKL/myocardin-like protein 2MKL1/myocardin like 2megakaryoblastic leukemia 2
Modification date2020032720200313
UniProtAcc

P08238

.
Ensembl transtripts involved in fusion geneENST00000353801, ENST00000371554, 
ENST00000371646, 		ENST00000341243, 
ENST00000572567, ENST00000573051, 
ENST00000575537, ENST00000571589, 
ENST00000574045, ENST00000318282, 
Fusion gene scores* DoF score20 X 20 X 7=280010 X 10 X 6=600
# samples 2210
** MAII scorelog2(22/2800*10)=-3.66985139830767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/600*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSP90AB1 [Title/Abstract] AND MKL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSP90AB1(44220004)-MKL2(14354765), # samples:1
Anticipated loss of major functional domain due to fusion event.HSP90AB1-MKL2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
HSP90AB1-MKL2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSP90AB1

GO:0007004

telomere maintenance via telomerase

10197982

HgeneHSP90AB1

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

24613385

HgeneHSP90AB1

GO:0031396

regulation of protein ubiquitination

16809764

HgeneHSP90AB1

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

24613385

HgeneHSP90AB1

GO:0032516

positive regulation of phosphoprotein phosphatase activity

26593036

HgeneHSP90AB1

GO:0051131

chaperone-mediated protein complex assembly

10811660

HgeneHSP90AB1

GO:0051973

positive regulation of telomerase activity

10197982

HgeneHSP90AB1

GO:1901389

negative regulation of transforming growth factor beta activation

20599762

HgeneHSP90AB1

GO:1905323

telomerase holoenzyme complex assembly

10197982

HgeneHSP90AB1

GO:2000010

positive regulation of protein localization to cell surface

23431407

TgeneMKL2

GO:0045844

positive regulation of striated muscle tissue development

14565952

TgeneMKL2

GO:0045944

positive regulation of transcription by RNA polymerase II

14565952


check buttonFusion gene breakpoints across HSP90AB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MKL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A88THSP90AB1chr6

44220004

+MKL2chr16

14354765

+


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Fusion Gene ORF analysis for HSP90AB1-MKL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000353801ENST00000341243HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
5CDS-intronENST00000353801ENST00000572567HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
5CDS-intronENST00000353801ENST00000573051HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
5CDS-intronENST00000353801ENST00000575537HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
5CDS-intronENST00000371554ENST00000341243HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
5CDS-intronENST00000371554ENST00000572567HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
5CDS-intronENST00000371554ENST00000573051HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
5CDS-intronENST00000371554ENST00000575537HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
5CDS-intronENST00000371646ENST00000341243HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
5CDS-intronENST00000371646ENST00000572567HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
5CDS-intronENST00000371646ENST00000573051HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
5CDS-intronENST00000371646ENST00000575537HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
Frame-shiftENST00000353801ENST00000571589HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
Frame-shiftENST00000353801ENST00000574045HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
Frame-shiftENST00000371554ENST00000571589HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
Frame-shiftENST00000371554ENST00000574045HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
Frame-shiftENST00000371646ENST00000571589HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
Frame-shiftENST00000371646ENST00000574045HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
In-frameENST00000353801ENST00000318282HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
In-frameENST00000371554ENST00000318282HSP90AB1chr6

44220004

+MKL2chr16

14354765

+
In-frameENST00000371646ENST00000318282HSP90AB1chr6

44220004

+MKL2chr16

14354765

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000353801HSP90AB1chr644220004+ENST00000318282MKL2chr1614354765+771718531221870582
ENST00000371646HSP90AB1chr644220004+ENST00000318282MKL2chr1614354765+77041840731857594
ENST00000371554HSP90AB1chr644220004+ENST00000318282MKL2chr1614354765+780919452141962582

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353801ENST00000318282HSP90AB1chr644220004+MKL2chr1614354765+0.0003937150.9996063
ENST00000371646ENST00000318282HSP90AB1chr644220004+MKL2chr1614354765+0.0003979790.999602
ENST00000371554ENST00000318282HSP90AB1chr644220004+MKL2chr1614354765+0.0003649080.9996351

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Fusion Genomic Features for HSP90AB1-MKL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HSP90AB1chr644220004+MKL2chr1614354765+0.078333330.9216666
HSP90AB1chr644220004+MKL2chr1614354765+0.078333330.9216666

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HSP90AB1-MKL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:44220004/chr16:14354765)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSP90AB1

P08238

.
FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMKL2chr6:44220004chr16:14354765ENST0000057305109545_6010379.0Coiled coilOntology_term=ECO:0000255
TgeneMKL2chr6:44220004chr16:14354765ENST0000057305109671_7870379.0Compositional biasNote=Gln-rich
TgeneMKL2chr6:44220004chr16:14354765ENST0000057305109389_4230379.0DomainSAP
TgeneMKL2chr6:44220004chr16:14354765ENST0000057305109128_1530379.0RepeatNote=RPEL 3
TgeneMKL2chr6:44220004chr16:14354765ENST000005730510940_650379.0RepeatNote=RPEL 1
TgeneMKL2chr6:44220004chr16:14354765ENST000005730510984_1090379.0RepeatNote=RPEL 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000353801+1012720_724577725.0MotifNote=TPR repeat-binding
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371554+1012720_724577725.0MotifNote=TPR repeat-binding
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371646+1012720_724577725.0MotifNote=TPR repeat-binding
TgeneMKL2chr6:44220004chr16:14354765ENST000003182821416545_6018711050.0Coiled coilOntology_term=ECO:0000255
TgeneMKL2chr6:44220004chr16:14354765ENST000003412431315545_6019101089.0Coiled coilOntology_term=ECO:0000255
TgeneMKL2chr6:44220004chr16:14354765ENST000005740451517545_6018711050.0Coiled coilOntology_term=ECO:0000255
TgeneMKL2chr6:44220004chr16:14354765ENST000003182821416671_7878711050.0Compositional biasNote=Gln-rich
TgeneMKL2chr6:44220004chr16:14354765ENST000003412431315671_7879101089.0Compositional biasNote=Gln-rich
TgeneMKL2chr6:44220004chr16:14354765ENST000005740451517671_7878711050.0Compositional biasNote=Gln-rich
TgeneMKL2chr6:44220004chr16:14354765ENST000003182821416389_4238711050.0DomainSAP
TgeneMKL2chr6:44220004chr16:14354765ENST000003412431315389_4239101089.0DomainSAP
TgeneMKL2chr6:44220004chr16:14354765ENST000005740451517389_4238711050.0DomainSAP
TgeneMKL2chr6:44220004chr16:14354765ENST000003182821416128_1538711050.0RepeatNote=RPEL 3
TgeneMKL2chr6:44220004chr16:14354765ENST00000318282141640_658711050.0RepeatNote=RPEL 1
TgeneMKL2chr6:44220004chr16:14354765ENST00000318282141684_1098711050.0RepeatNote=RPEL 2
TgeneMKL2chr6:44220004chr16:14354765ENST000003412431315128_1539101089.0RepeatNote=RPEL 3
TgeneMKL2chr6:44220004chr16:14354765ENST00000341243131540_659101089.0RepeatNote=RPEL 1
TgeneMKL2chr6:44220004chr16:14354765ENST00000341243131584_1099101089.0RepeatNote=RPEL 2
TgeneMKL2chr6:44220004chr16:14354765ENST000005740451517128_1538711050.0RepeatNote=RPEL 3
TgeneMKL2chr6:44220004chr16:14354765ENST00000574045151740_658711050.0RepeatNote=RPEL 1
TgeneMKL2chr6:44220004chr16:14354765ENST00000574045151784_1098711050.0RepeatNote=RPEL 2


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Fusion Gene Sequence for HSP90AB1-MKL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37802_37802_1_HSP90AB1-MKL2_HSP90AB1_chr6_44220004_ENST00000353801_MKL2_chr16_14354765_ENST00000318282_length(transcript)=7717nt_BP=1853nt
GGCACGCAGTAGCTCTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTA
TAATCCTTTTCTTTTCAAGATTTTTATTTTAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAG
AAATTGCCCAACTCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATG
CCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCCTC
AGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTA
CTAAAGCATTCATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGG
CAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTG
ACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAG
AAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATTTGGAGAAGGAACGAGAGAAGGAAATTAGTGATGATGAGG
CAGAGGAAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAAGAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATG
ACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGA
CCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTACAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGC
ACTTTTCTGTAGAAGGTCAGTTGGAATTCAGGGCATTGCTATTTATTCCTCGTCGGGCTCCCTTTGACCTTTTTGAGAACAAGAAGAAAA
AGAACAACATCAAACTCTATGTCCGCCGTGTGTTCATCATGGACAGCTGTGATGAGTTGATACCAGAGTATCTCAATTTTATCCGTGGTG
TGGTTGACTCTGAGGATCTGCCCCTGAACATCTCCCGAGAAATGCTCCAGCAGAGCAAAATCTTGAAAGTCATTCGCAAAAACATTGTTA
AGAAGTGCCTTGAGCTCTTCTCTGAGCTGGCAGAAGACAAGGAGAATTACAAGAAATTCTATGAGGCATTCTCTAAAAATCTCAAGCTTG
GAATCCACGAAGACTCCACTAACCGCCGCCGCCTGTCTGAGCTGCTGCGCTATCATACCTCCCAGTCTGGAGATGAGATGACATCTCTGT
CAGAGTATGTTTCTCGCATGAAGGAGACACAGAAGTCCATCTATTACATCACTGGTGAGAGCAAAGAGCAGGTGGCCAACTCAGCTTTTG
TGGAGCGAGTGCGGAAACGGGGCTTCGAGGTGGTATATATGACCGAGCCCATTGACGAGTACTGTGTGCAGCAGCTCAAGGAATTTGATG
GGAAGAGCCTGGTCTCAGTTACCAAGGAGGGTCTGGAGCTGCCTGAGGATGAGGAGGAGAAGAAGAAGATGGAAGAGAGCAAGGCAAAGT
TTGAGAACCTCTGCAAGCTCATGAAAGAAATCTTAGATAAGAAGGTTGAGAAGAGATCTCCCTCCCCATAAAAGAAGAACCTTCTCCTAT
TTCCAAAATGAGACCAGTGACAGCCAGCATCACCACAATGCCAGTGAATACAGTGGTGTCCCGGCCACCACCCCAAGTCCAAATGGCACC
ACCTGTATCTTTAGAACCTATGGGCAGTTTATCTGCCAGCTTAGAGAACCAACTAGAAGCTTTCTTGGATGGAACTTTACCCTCAGCCAA
TGAAATTCCTCCACTACAAAGCAGCAGTGAAGACAGAGAGCCCTTCTCTCTGATCGAGGACCTCCAGAATGATCTGCTGAGTCACTCAGG
TATGCTGGACCATTCACACTCACCCATGGAGACTTCCGAGACCCAGTTTGCTGCAGGTACTCCCTGTCTGTCTCTCGACCTGTCAGACTC
AAACTTGGACAACATGGAGTGGTTGGACATTACCATGCCCAACTCCTCTTCAGGACTCACTCCTCTCAGCACCACCGCGCCGAGCATGTT
CTCTGCTGACTTTCTAGACCCACAGGACCTACCGCTGCCATGGGACTAACGTCACAGATTTCTTTTCTGAGAGTTGATGAGGTTTAAGAA
CATGAAGATTCTAAAAGGTCAGTTTTTAGAGATAGATCTATAGTTGCATTGTTGCAATCAAAATATGTTGTCACAGAAAGAATAGGTGGA
AGGTCATAGCCTGGAACCCAAGTTTGAAAACATTTCATTGTGTTCAGTAGTGAATTTCTACAGTTTAACATAGCACAGGGCCTTCTGAAA
ATCGCACTTGTCAAAGACGACTCATCTATTTCTCCAGACTTCAGTAAAGAATGAAAAGTACCTTTAGATAAAAACAAAGAAGAGTAATAT
ATGCAGCACAGTGACGTTAGGATTCTGGTAATTAACTACATTTAAATCTCTGGTCACTTTAAGACCCTAAATAAAAGGCAGACAGCTCCA
CTCAAAAACTAAGGCTGATGTGAGGGAGGTGAGAGGTCACTGCACTTGGTACTTCCTAGAGACGGCCGGAGCCAGGCCCAAGACACAGCA
GAGGTCAAAGGCAGTGGAGAGCCTTGGCCAGTTCAGTGACAGCTTCTGGCTGAAGACTTTTGGTTCTATTCAGAAACCTGTGTCGTTTTT
TTGGTGTTGTAGTTTATTTTGTGATTTTTTGGAATCGTACTTTATATTTCCAAATTTAAATTTAAATGCAAGATCTTTCAACATAAACAG
AAGATACCTACAAAATACTGTCAGAAGTCCAGGTATACTGATAACACTGAAAATTCTATTAGCAACCTTCTGGGTTGGTTAGATTGATTT
TAATGTATATATTAGACATTTGTATGTATGCTCTGACATTGTGATTTGTACAGCCTACGCTGGGGTAAGGAAATGGGTATCCAAGGTCCT
ACTTTTTTAATAGCTCGAATATTTCTAGAGTACTTGAGCCACATGTATTTCTGTATTTAAAGAATTGCTGACTAACTTTCAGGTAACCAG
ACCCATCTCAAAGAACCAAGAAAAGGCTTTAGCATGAAATATCTTTCTGAGCTGGCGAGTTAGAAGAATGGAAGGTAAGGGGAAGGTCTG
TCATCTACCCAGGACATTCCCATGATGAGTACAGGTCAGATTGTGCCACAAGGTGGGCCTCCACGTCCCTGCCCTGGCCCTCTTTCTTCT
GTCACTAACCCTGGTTATCATTTTACAGGCTTGTAACTGGATATTCTACCAGAGCTCTCACTATATTGTCAAGCCTAAGATTGAAAAACT
GGAGGCTTTATTAGTGTTTTTATATAGAAAACAGTTATTACATATGTGTTAAGTCATTTCTTAAGAATTTTCTAAAATGCCAACTATCAC
AGGATTATTTCAAGCTAGTCATTGAGGTATATGACAAAATGTAAATAACAAAAAACTGAAATCTACCAAAAGAGCATGGAGATTTTTCTT
AAATAATAATATTGTGCTCTCCACCTCACCCTTGTGTAAACCCTCAGGTCAGGTTGGTTCCCCTGGGTCACAAAATGGTAAATGTTCCAT
ACTGACATGCCGGAGGCAGCCTGACCCGTTATTTGGAAAGAATTTGTGAATTATTTCTGGGTTTGTGTTTTGCCTAAGAGCTGATCTTAT
TTCTGATTTGTGTGTGTGTGGTTTATAAATTTTACTACGTGTAACAAAAGTCTGCTTTTCCAGCATGAGCACACTGGAGCCCTCTGCTCA
CTGGCACTTCCTGACTCAAAGGCACTAACAGTGCTCATGTGCCTTCCAGACGGTTCAAGGCAGAGGCCACTGTGCTCAGTGTAGTCTGTG
ATGAATAGTTTAAGTGTTCAGAAATTGGTAAACCAACACACGGGATACAATAACTCTCTGTTAACCAGAACACCGTCATTTGACCAAGCC
CTACAAGAGTTTACCACACTAGATGTTCTGTGAATCCTCGAGTCAGTTCCATTGAGAGGGGCCTGTCTCCAGGGCCAGGCTATTTACTTG
GGAAAGTATTTTTCTTACAGTTCTTGGCCACAGTTTTTTTGCTGAGGGTTTCTGTCTGGGCCTATCAGGTCCATACTTAGACCCTGAGCA
TCTTCTTCATTCAGATTTGAATGGCTTATTAAATTAGCACCAAATATCAGTGGGACTGTAGAAGGTAACCGAACACTAGTACCATTGACT
CTCGTTGAATAACTTTATATTTCCATAATCCTGAATTGTGTAGATAGTTTTCTAGCTCTCGGGTCCCTTTATTGCTTTTTAAAATAGGGT
TTGAAACATGCCACAGGAAGGTTGCTCTCCAAAAATACACAGTGCAGTGCAAGAAAATGCTATCTCATTGGCCTACTCTCCTATGAATTG
CTAAAGTGCCCACTTCACATATGTGTTTAAACCTTTATAAACCAGTATTTCACTTTTAAAAAGACAAGGCATCTCTACCCATTAACTCTG
CAAGCCACTCCACTTGCACCATTCCGCTTGACCCTCCTCTCTCCTGGCTTGGGTCACCAGCCAGGCACCTGTGACACGAGTGCTGCTCTC
CAGGATCTCCACTACATGTTCCAGGTTGGAGTGAGGACGCGCTATGTGCTCACACTCATGTGACATGACCAAAGATGATACTCTGTAAAC
AAGGCCCTTCTGACCGGACTCAGTGCGTGTGATGGTGAGTGCAATGAGGAAGGGTGGATATTGACTAAAGACTGGTTGTTGTTGTTGTTT
AGGTTAGTGTCACAGCCATTACAGCACAAGTCAAAGTCGCCAGTTGAATTTTCATTATGCACGTGTGTGGTTTAAGCAGTGGTACTGTTG
TATATCATATTGTAAAGTATCATACTGCCAAGAAAATAACTCCTAGAAAGGCATTATCTCACATCCCCATCTTACTTTCCTACATGTTCT
CAAAACACAGTAGTACCAGCCTTACCTTTCTGCTGTATGTAGATAGTCAGATCATCCTACTGGGGGTGGGATGAATTTAAAAGTTATACC
AAAATTTCTGTAAAGTCTTTGAAAGTCTAGGAGTAGGTGGTCATCTTGTACATTTCAGCAAAGCATCCACTAGGAAACCTCATAGGACAG
TGTTAGTGGTTCACGTTCTAGTGTTTTTCCTGAAATGTGCAATCTACTGTATAGTATTGCCACATAATTGTACATAGATGTATTCTGAAT
TTGTGGAATTTCTTGCTTAGATACTATTGTGTTTGTTTCATATGAATATTTTTGTAATTCTAAAAGAGATCTTATTTAAATTTCCTTTTT
AAAAGCCGCATGGTTCTGTGATCCATGTAACTGACACTTTTTGGCTTTCAGTGCTGTTTAGAAACAGTGGCAAAGGCAGGGTGGTGCTGC
CTGCAAGCTGCTGCCTATGGAAGGCAAAGTCATAGTAATGAGATAGCACCTCTGAACTGTGCAGTCAGCATACCCTGAGTGATGGCTCAG
GGGCGCACTACCTATTTTGTCACCAGAGCTGACTCAGGCTTCCTGGACCCTCAACCCCAGATCATTCCAGGCAGCATAGCTTTCTTCACA
GTCCTTTCAGAATTCCCAGGCTGAAATCAGCCATAGCAGTTGACAAAACAGCTATCCCCACAAGTGATGAGATAGTCCCTTTACTGTCCT
CAAATGGACTTGGCCTTAGAGACGTGGTAAAGCACTTTGGCAGGGTTTAAAATATTTGTGAGAAGCCCACATTTCAGTATACATCCTCAC
TGGCTTCCATGCACCCACCTGACGGTAGCCTCACAGAAGTCCTGGCTGTCACTCAGGTGGGGAGCTCATGGTGCCGCTGGGGACTTTTTA
GAGAAATGTAAAGAGAATAGCTATTCAGTGTCTACTAGCAGAGCAACATGTGTCAATTTAACCAAATTCACAAATAACCCTCCATTTTTC
AATATCTGCTACTGTAAACATGAATATTGAATACTGACAAGAGAATACCCATACAAATCGTCCCACCGCCCTAGAGGCCACAGAATTAGC
CCAAAATTATCAAAGAACATTAACTGGAAGGTCAGGTTTTTCAAGGAACATAGCTTACAAATGCATCAGTGTGTATCTGGAGAGCATCCT
AACTGCATTTCAACTCATCTTTTAAGTGATTTCAGTCAAAACTGGAAAACAACTAAGATGTAGTAATTTTTTTTTCCTGGTTCAAACCTT
CAATAACTTGCTCATTCAGCAGTCTCTCTGAGCTACATTTTTATTTGTAAAGTGACTCTGTCTGCATGGCAATGAGCAGGTGCGTGTTTT
TTCCACATTCGCCCTTTCTTGCAGTATCCAGGGAAACACATCATTACAAAGGGTTTCTACCTGAAATCTTTCATGGAAGGCCTACAATTC
GAAAAGCTGCACATGTTTACAGAAGAGCTCTTACCCTCCATGCAAACACTTTGCTCTGTGGTGTCACAGCTTTGTGACAATAAGATGGCA
ATCTCGGATCTACAAGGTGCTGTCGGGAATCAAATAAAATATGTTATCAGAGATATCATCACATCTATAGTGTTTAACAGAGCTTTATGC
CAACTACTAAGACAAAGCTTTAACAAAGTTTATAGAATACTGAAACTCGTAACAATTACCTCTCTACGTGATGCTGTAAGGAATCTTGCT
AATTTGGTAGGAAGAGGAAGCATTTAGGAAAGGGTTTAGTATCTACCAAAAGTACTTGACCTCAAGTAACCAATAGTAATGCAAACTTGC
TTTAAAGGAACCAAAGGCATTGCCAAGTATTTGCCAAAAGGAGGCACTTTTTATTTAAAATTTGAGACTAATGAGATCTCAAAAATCAGC
CCCAAAAAGGTATTATCCATTTAAGGTTATAATTTTCACTAAGATGTAGATATTTCTCTTATTGTTTTCATGTAAAATAGTATAGAGTTG
TTTTGTTGGTTTAAGAGTAACATTCAGTAGTAATACAAAGTTTTTTTTCTATGTAGAAATTAGTTTTCTTTTCTTGCTTGCAATAGAAAT
GCAATGTGATAGGTGTTTCTCTTCTTATTTTCATTGTCACATTATGTCTTAGCATCTCACTTTATGAAAAAAAGGAGAAAGATACCAATC
TACAGAGCCCTGCTTGTTGAAGCACTAGTTTAATCAACAAAAAATTATGGCAATCGGGGGTCCATTCATCTATTGCCTTTATGTTGTTTT
TTAAAAGAAAAACCATGATGCCTTTGTATTTGCTGTTTGCACCCCTGAAATCAATTCCATATCATGTTTGAATGCCATACATTTTGCACA
TGTACTGTACATAAGTAATGCATACTGTATTTTTATATGTGTGCACATTTATCATCAGATCTTTTGTACATAGTGGCAGTATTGTAGCTG

>37802_37802_1_HSP90AB1-MKL2_HSP90AB1_chr6_44220004_ENST00000353801_MKL2_chr16_14354765_ENST00000318282_length(amino acids)=582AA_BP=
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTK
KIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR
LSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG

--------------------------------------------------------------
>37802_37802_2_HSP90AB1-MKL2_HSP90AB1_chr6_44220004_ENST00000371554_MKL2_chr16_14354765_ENST00000318282_length(transcript)=7809nt_BP=1945nt
GTGCCCGGATGCTGGGGCGAGGGAGGGTGCACTGCGGCGCCCCCTCCTCGCGTGGTCCTGGCCGACGCATGTCCGGCAGTGACGAGTGTC
GGCCTGGTGGCTACGGCCACCATCTTTCTTGGGTTTGGTCCTGTTCTGTAATTTTGTGCTGTGAAAGGGTCGTGGTGGAGCTTTTGGCTT
AAGAATTCTTTGTCCGGATTTAATTGCTCCTCCGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGC
AGAAATTGCCCAACTCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGA
TGCCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCC
TCAGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGG
TACTAAAGCATTCATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGT
GGCAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGC
TGACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAA
AGAAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATTTGGAGAAGGAACGAGAGAAGGAAATTAGTGATGATGA
GGCAGAGGAAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAAGAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGA
TGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTG
GACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTACAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAA
GCACTTTTCTGTAGAAGGTCAGTTGGAATTCAGGGCATTGCTATTTATTCCTCGTCGGGCTCCCTTTGACCTTTTTGAGAACAAGAAGAA
AAAGAACAACATCAAACTCTATGTCCGCCGTGTGTTCATCATGGACAGCTGTGATGAGTTGATACCAGAGTATCTCAATTTTATCCGTGG
TGTGGTTGACTCTGAGGATCTGCCCCTGAACATCTCCCGAGAAATGCTCCAGCAGAGCAAAATCTTGAAAGTCATTCGCAAAAACATTGT
TAAGAAGTGCCTTGAGCTCTTCTCTGAGCTGGCAGAAGACAAGGAGAATTACAAGAAATTCTATGAGGCATTCTCTAAAAATCTCAAGCT
TGGAATCCACGAAGACTCCACTAACCGCCGCCGCCTGTCTGAGCTGCTGCGCTATCATACCTCCCAGTCTGGAGATGAGATGACATCTCT
GTCAGAGTATGTTTCTCGCATGAAGGAGACACAGAAGTCCATCTATTACATCACTGGTGAGAGCAAAGAGCAGGTGGCCAACTCAGCTTT
TGTGGAGCGAGTGCGGAAACGGGGCTTCGAGGTGGTATATATGACCGAGCCCATTGACGAGTACTGTGTGCAGCAGCTCAAGGAATTTGA
TGGGAAGAGCCTGGTCTCAGTTACCAAGGAGGGTCTGGAGCTGCCTGAGGATGAGGAGGAGAAGAAGAAGATGGAAGAGAGCAAGGCAAA
GTTTGAGAACCTCTGCAAGCTCATGAAAGAAATCTTAGATAAGAAGGTTGAGAAGAGATCTCCCTCCCCATAAAAGAAGAACCTTCTCCT
ATTTCCAAAATGAGACCAGTGACAGCCAGCATCACCACAATGCCAGTGAATACAGTGGTGTCCCGGCCACCACCCCAAGTCCAAATGGCA
CCACCTGTATCTTTAGAACCTATGGGCAGTTTATCTGCCAGCTTAGAGAACCAACTAGAAGCTTTCTTGGATGGAACTTTACCCTCAGCC
AATGAAATTCCTCCACTACAAAGCAGCAGTGAAGACAGAGAGCCCTTCTCTCTGATCGAGGACCTCCAGAATGATCTGCTGAGTCACTCA
GGTATGCTGGACCATTCACACTCACCCATGGAGACTTCCGAGACCCAGTTTGCTGCAGGTACTCCCTGTCTGTCTCTCGACCTGTCAGAC
TCAAACTTGGACAACATGGAGTGGTTGGACATTACCATGCCCAACTCCTCTTCAGGACTCACTCCTCTCAGCACCACCGCGCCGAGCATG
TTCTCTGCTGACTTTCTAGACCCACAGGACCTACCGCTGCCATGGGACTAACGTCACAGATTTCTTTTCTGAGAGTTGATGAGGTTTAAG
AACATGAAGATTCTAAAAGGTCAGTTTTTAGAGATAGATCTATAGTTGCATTGTTGCAATCAAAATATGTTGTCACAGAAAGAATAGGTG
GAAGGTCATAGCCTGGAACCCAAGTTTGAAAACATTTCATTGTGTTCAGTAGTGAATTTCTACAGTTTAACATAGCACAGGGCCTTCTGA
AAATCGCACTTGTCAAAGACGACTCATCTATTTCTCCAGACTTCAGTAAAGAATGAAAAGTACCTTTAGATAAAAACAAAGAAGAGTAAT
ATATGCAGCACAGTGACGTTAGGATTCTGGTAATTAACTACATTTAAATCTCTGGTCACTTTAAGACCCTAAATAAAAGGCAGACAGCTC
CACTCAAAAACTAAGGCTGATGTGAGGGAGGTGAGAGGTCACTGCACTTGGTACTTCCTAGAGACGGCCGGAGCCAGGCCCAAGACACAG
CAGAGGTCAAAGGCAGTGGAGAGCCTTGGCCAGTTCAGTGACAGCTTCTGGCTGAAGACTTTTGGTTCTATTCAGAAACCTGTGTCGTTT
TTTTGGTGTTGTAGTTTATTTTGTGATTTTTTGGAATCGTACTTTATATTTCCAAATTTAAATTTAAATGCAAGATCTTTCAACATAAAC
AGAAGATACCTACAAAATACTGTCAGAAGTCCAGGTATACTGATAACACTGAAAATTCTATTAGCAACCTTCTGGGTTGGTTAGATTGAT
TTTAATGTATATATTAGACATTTGTATGTATGCTCTGACATTGTGATTTGTACAGCCTACGCTGGGGTAAGGAAATGGGTATCCAAGGTC
CTACTTTTTTAATAGCTCGAATATTTCTAGAGTACTTGAGCCACATGTATTTCTGTATTTAAAGAATTGCTGACTAACTTTCAGGTAACC
AGACCCATCTCAAAGAACCAAGAAAAGGCTTTAGCATGAAATATCTTTCTGAGCTGGCGAGTTAGAAGAATGGAAGGTAAGGGGAAGGTC
TGTCATCTACCCAGGACATTCCCATGATGAGTACAGGTCAGATTGTGCCACAAGGTGGGCCTCCACGTCCCTGCCCTGGCCCTCTTTCTT
CTGTCACTAACCCTGGTTATCATTTTACAGGCTTGTAACTGGATATTCTACCAGAGCTCTCACTATATTGTCAAGCCTAAGATTGAAAAA
CTGGAGGCTTTATTAGTGTTTTTATATAGAAAACAGTTATTACATATGTGTTAAGTCATTTCTTAAGAATTTTCTAAAATGCCAACTATC
ACAGGATTATTTCAAGCTAGTCATTGAGGTATATGACAAAATGTAAATAACAAAAAACTGAAATCTACCAAAAGAGCATGGAGATTTTTC
TTAAATAATAATATTGTGCTCTCCACCTCACCCTTGTGTAAACCCTCAGGTCAGGTTGGTTCCCCTGGGTCACAAAATGGTAAATGTTCC
ATACTGACATGCCGGAGGCAGCCTGACCCGTTATTTGGAAAGAATTTGTGAATTATTTCTGGGTTTGTGTTTTGCCTAAGAGCTGATCTT
ATTTCTGATTTGTGTGTGTGTGGTTTATAAATTTTACTACGTGTAACAAAAGTCTGCTTTTCCAGCATGAGCACACTGGAGCCCTCTGCT
CACTGGCACTTCCTGACTCAAAGGCACTAACAGTGCTCATGTGCCTTCCAGACGGTTCAAGGCAGAGGCCACTGTGCTCAGTGTAGTCTG
TGATGAATAGTTTAAGTGTTCAGAAATTGGTAAACCAACACACGGGATACAATAACTCTCTGTTAACCAGAACACCGTCATTTGACCAAG
CCCTACAAGAGTTTACCACACTAGATGTTCTGTGAATCCTCGAGTCAGTTCCATTGAGAGGGGCCTGTCTCCAGGGCCAGGCTATTTACT
TGGGAAAGTATTTTTCTTACAGTTCTTGGCCACAGTTTTTTTGCTGAGGGTTTCTGTCTGGGCCTATCAGGTCCATACTTAGACCCTGAG
CATCTTCTTCATTCAGATTTGAATGGCTTATTAAATTAGCACCAAATATCAGTGGGACTGTAGAAGGTAACCGAACACTAGTACCATTGA
CTCTCGTTGAATAACTTTATATTTCCATAATCCTGAATTGTGTAGATAGTTTTCTAGCTCTCGGGTCCCTTTATTGCTTTTTAAAATAGG
GTTTGAAACATGCCACAGGAAGGTTGCTCTCCAAAAATACACAGTGCAGTGCAAGAAAATGCTATCTCATTGGCCTACTCTCCTATGAAT
TGCTAAAGTGCCCACTTCACATATGTGTTTAAACCTTTATAAACCAGTATTTCACTTTTAAAAAGACAAGGCATCTCTACCCATTAACTC
TGCAAGCCACTCCACTTGCACCATTCCGCTTGACCCTCCTCTCTCCTGGCTTGGGTCACCAGCCAGGCACCTGTGACACGAGTGCTGCTC
TCCAGGATCTCCACTACATGTTCCAGGTTGGAGTGAGGACGCGCTATGTGCTCACACTCATGTGACATGACCAAAGATGATACTCTGTAA
ACAAGGCCCTTCTGACCGGACTCAGTGCGTGTGATGGTGAGTGCAATGAGGAAGGGTGGATATTGACTAAAGACTGGTTGTTGTTGTTGT
TTAGGTTAGTGTCACAGCCATTACAGCACAAGTCAAAGTCGCCAGTTGAATTTTCATTATGCACGTGTGTGGTTTAAGCAGTGGTACTGT
TGTATATCATATTGTAAAGTATCATACTGCCAAGAAAATAACTCCTAGAAAGGCATTATCTCACATCCCCATCTTACTTTCCTACATGTT
CTCAAAACACAGTAGTACCAGCCTTACCTTTCTGCTGTATGTAGATAGTCAGATCATCCTACTGGGGGTGGGATGAATTTAAAAGTTATA
CCAAAATTTCTGTAAAGTCTTTGAAAGTCTAGGAGTAGGTGGTCATCTTGTACATTTCAGCAAAGCATCCACTAGGAAACCTCATAGGAC
AGTGTTAGTGGTTCACGTTCTAGTGTTTTTCCTGAAATGTGCAATCTACTGTATAGTATTGCCACATAATTGTACATAGATGTATTCTGA
ATTTGTGGAATTTCTTGCTTAGATACTATTGTGTTTGTTTCATATGAATATTTTTGTAATTCTAAAAGAGATCTTATTTAAATTTCCTTT
TTAAAAGCCGCATGGTTCTGTGATCCATGTAACTGACACTTTTTGGCTTTCAGTGCTGTTTAGAAACAGTGGCAAAGGCAGGGTGGTGCT
GCCTGCAAGCTGCTGCCTATGGAAGGCAAAGTCATAGTAATGAGATAGCACCTCTGAACTGTGCAGTCAGCATACCCTGAGTGATGGCTC
AGGGGCGCACTACCTATTTTGTCACCAGAGCTGACTCAGGCTTCCTGGACCCTCAACCCCAGATCATTCCAGGCAGCATAGCTTTCTTCA
CAGTCCTTTCAGAATTCCCAGGCTGAAATCAGCCATAGCAGTTGACAAAACAGCTATCCCCACAAGTGATGAGATAGTCCCTTTACTGTC
CTCAAATGGACTTGGCCTTAGAGACGTGGTAAAGCACTTTGGCAGGGTTTAAAATATTTGTGAGAAGCCCACATTTCAGTATACATCCTC
ACTGGCTTCCATGCACCCACCTGACGGTAGCCTCACAGAAGTCCTGGCTGTCACTCAGGTGGGGAGCTCATGGTGCCGCTGGGGACTTTT
TAGAGAAATGTAAAGAGAATAGCTATTCAGTGTCTACTAGCAGAGCAACATGTGTCAATTTAACCAAATTCACAAATAACCCTCCATTTT
TCAATATCTGCTACTGTAAACATGAATATTGAATACTGACAAGAGAATACCCATACAAATCGTCCCACCGCCCTAGAGGCCACAGAATTA
GCCCAAAATTATCAAAGAACATTAACTGGAAGGTCAGGTTTTTCAAGGAACATAGCTTACAAATGCATCAGTGTGTATCTGGAGAGCATC
CTAACTGCATTTCAACTCATCTTTTAAGTGATTTCAGTCAAAACTGGAAAACAACTAAGATGTAGTAATTTTTTTTTCCTGGTTCAAACC
TTCAATAACTTGCTCATTCAGCAGTCTCTCTGAGCTACATTTTTATTTGTAAAGTGACTCTGTCTGCATGGCAATGAGCAGGTGCGTGTT
TTTTCCACATTCGCCCTTTCTTGCAGTATCCAGGGAAACACATCATTACAAAGGGTTTCTACCTGAAATCTTTCATGGAAGGCCTACAAT
TCGAAAAGCTGCACATGTTTACAGAAGAGCTCTTACCCTCCATGCAAACACTTTGCTCTGTGGTGTCACAGCTTTGTGACAATAAGATGG
CAATCTCGGATCTACAAGGTGCTGTCGGGAATCAAATAAAATATGTTATCAGAGATATCATCACATCTATAGTGTTTAACAGAGCTTTAT
GCCAACTACTAAGACAAAGCTTTAACAAAGTTTATAGAATACTGAAACTCGTAACAATTACCTCTCTACGTGATGCTGTAAGGAATCTTG
CTAATTTGGTAGGAAGAGGAAGCATTTAGGAAAGGGTTTAGTATCTACCAAAAGTACTTGACCTCAAGTAACCAATAGTAATGCAAACTT
GCTTTAAAGGAACCAAAGGCATTGCCAAGTATTTGCCAAAAGGAGGCACTTTTTATTTAAAATTTGAGACTAATGAGATCTCAAAAATCA
GCCCCAAAAAGGTATTATCCATTTAAGGTTATAATTTTCACTAAGATGTAGATATTTCTCTTATTGTTTTCATGTAAAATAGTATAGAGT
TGTTTTGTTGGTTTAAGAGTAACATTCAGTAGTAATACAAAGTTTTTTTTCTATGTAGAAATTAGTTTTCTTTTCTTGCTTGCAATAGAA
ATGCAATGTGATAGGTGTTTCTCTTCTTATTTTCATTGTCACATTATGTCTTAGCATCTCACTTTATGAAAAAAAGGAGAAAGATACCAA
TCTACAGAGCCCTGCTTGTTGAAGCACTAGTTTAATCAACAAAAAATTATGGCAATCGGGGGTCCATTCATCTATTGCCTTTATGTTGTT
TTTTAAAAGAAAAACCATGATGCCTTTGTATTTGCTGTTTGCACCCCTGAAATCAATTCCATATCATGTTTGAATGCCATACATTTTGCA
CATGTACTGTACATAAGTAATGCATACTGTATTTTTATATGTGTGCACATTTATCATCAGATCTTTTGTACATAGTGGCAGTATTGTAGC

>37802_37802_2_HSP90AB1-MKL2_HSP90AB1_chr6_44220004_ENST00000371554_MKL2_chr16_14354765_ENST00000318282_length(amino acids)=582AA_BP=
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTK
KIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR
LSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG

--------------------------------------------------------------
>37802_37802_3_HSP90AB1-MKL2_HSP90AB1_chr6_44220004_ENST00000371646_MKL2_chr16_14354765_ENST00000318282_length(transcript)=7704nt_BP=1840nt
GGCACGCAGTAGCTCTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTA
TAATCCTTTTCTTTTCAAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAGAAATTGCCCAACT
CATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATGCCTTGGACAAGAT
TCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCCTCAGGAACGTACCCT
GACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTACTAAAGCATTCAT
GGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGGCAGAGAAAGTGGT
TGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTGACCATGGTGAGCC
CATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAGAAGTAGTGAAGAA
GCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATTTGGAGAAGGAACGAGAGAAGGAAATTAGTGATGATGAGGCAGAGGAAGAGAA
AGGTGAGAAAGAAGAGGAAGATAAAGATGATGAAGAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGA
TAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGA
TGACATCACCCAAGAGGAGTATGGAGAATTCTACAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGCACTTTTCTGTAGA
AGGTCAGTTGGAATTCAGGGCATTGCTATTTATTCCTCGTCGGGCTCCCTTTGACCTTTTTGAGAACAAGAAGAAAAAGAACAACATCAA
ACTCTATGTCCGCCGTGTGTTCATCATGGACAGCTGTGATGAGTTGATACCAGAGTATCTCAATTTTATCCGTGGTGTGGTTGACTCTGA
GGATCTGCCCCTGAACATCTCCCGAGAAATGCTCCAGCAGAGCAAAATCTTGAAAGTCATTCGCAAAAACATTGTTAAGAAGTGCCTTGA
GCTCTTCTCTGAGCTGGCAGAAGACAAGGAGAATTACAAGAAATTCTATGAGGCATTCTCTAAAAATCTCAAGCTTGGAATCCACGAAGA
CTCCACTAACCGCCGCCGCCTGTCTGAGCTGCTGCGCTATCATACCTCCCAGTCTGGAGATGAGATGACATCTCTGTCAGAGTATGTTTC
TCGCATGAAGGAGACACAGAAGTCCATCTATTACATCACTGGTGAGAGCAAAGAGCAGGTGGCCAACTCAGCTTTTGTGGAGCGAGTGCG
GAAACGGGGCTTCGAGGTGGTATATATGACCGAGCCCATTGACGAGTACTGTGTGCAGCAGCTCAAGGAATTTGATGGGAAGAGCCTGGT
CTCAGTTACCAAGGAGGGTCTGGAGCTGCCTGAGGATGAGGAGGAGAAGAAGAAGATGGAAGAGAGCAAGGCAAAGTTTGAGAACCTCTG
CAAGCTCATGAAAGAAATCTTAGATAAGAAGGTTGAGAAGAGATCTCCCTCCCCATAAAAGAAGAACCTTCTCCTATTTCCAAAATGAGA
CCAGTGACAGCCAGCATCACCACAATGCCAGTGAATACAGTGGTGTCCCGGCCACCACCCCAAGTCCAAATGGCACCACCTGTATCTTTA
GAACCTATGGGCAGTTTATCTGCCAGCTTAGAGAACCAACTAGAAGCTTTCTTGGATGGAACTTTACCCTCAGCCAATGAAATTCCTCCA
CTACAAAGCAGCAGTGAAGACAGAGAGCCCTTCTCTCTGATCGAGGACCTCCAGAATGATCTGCTGAGTCACTCAGGTATGCTGGACCAT
TCACACTCACCCATGGAGACTTCCGAGACCCAGTTTGCTGCAGGTACTCCCTGTCTGTCTCTCGACCTGTCAGACTCAAACTTGGACAAC
ATGGAGTGGTTGGACATTACCATGCCCAACTCCTCTTCAGGACTCACTCCTCTCAGCACCACCGCGCCGAGCATGTTCTCTGCTGACTTT
CTAGACCCACAGGACCTACCGCTGCCATGGGACTAACGTCACAGATTTCTTTTCTGAGAGTTGATGAGGTTTAAGAACATGAAGATTCTA
AAAGGTCAGTTTTTAGAGATAGATCTATAGTTGCATTGTTGCAATCAAAATATGTTGTCACAGAAAGAATAGGTGGAAGGTCATAGCCTG
GAACCCAAGTTTGAAAACATTTCATTGTGTTCAGTAGTGAATTTCTACAGTTTAACATAGCACAGGGCCTTCTGAAAATCGCACTTGTCA
AAGACGACTCATCTATTTCTCCAGACTTCAGTAAAGAATGAAAAGTACCTTTAGATAAAAACAAAGAAGAGTAATATATGCAGCACAGTG
ACGTTAGGATTCTGGTAATTAACTACATTTAAATCTCTGGTCACTTTAAGACCCTAAATAAAAGGCAGACAGCTCCACTCAAAAACTAAG
GCTGATGTGAGGGAGGTGAGAGGTCACTGCACTTGGTACTTCCTAGAGACGGCCGGAGCCAGGCCCAAGACACAGCAGAGGTCAAAGGCA
GTGGAGAGCCTTGGCCAGTTCAGTGACAGCTTCTGGCTGAAGACTTTTGGTTCTATTCAGAAACCTGTGTCGTTTTTTTGGTGTTGTAGT
TTATTTTGTGATTTTTTGGAATCGTACTTTATATTTCCAAATTTAAATTTAAATGCAAGATCTTTCAACATAAACAGAAGATACCTACAA
AATACTGTCAGAAGTCCAGGTATACTGATAACACTGAAAATTCTATTAGCAACCTTCTGGGTTGGTTAGATTGATTTTAATGTATATATT
AGACATTTGTATGTATGCTCTGACATTGTGATTTGTACAGCCTACGCTGGGGTAAGGAAATGGGTATCCAAGGTCCTACTTTTTTAATAG
CTCGAATATTTCTAGAGTACTTGAGCCACATGTATTTCTGTATTTAAAGAATTGCTGACTAACTTTCAGGTAACCAGACCCATCTCAAAG
AACCAAGAAAAGGCTTTAGCATGAAATATCTTTCTGAGCTGGCGAGTTAGAAGAATGGAAGGTAAGGGGAAGGTCTGTCATCTACCCAGG
ACATTCCCATGATGAGTACAGGTCAGATTGTGCCACAAGGTGGGCCTCCACGTCCCTGCCCTGGCCCTCTTTCTTCTGTCACTAACCCTG
GTTATCATTTTACAGGCTTGTAACTGGATATTCTACCAGAGCTCTCACTATATTGTCAAGCCTAAGATTGAAAAACTGGAGGCTTTATTA
GTGTTTTTATATAGAAAACAGTTATTACATATGTGTTAAGTCATTTCTTAAGAATTTTCTAAAATGCCAACTATCACAGGATTATTTCAA
GCTAGTCATTGAGGTATATGACAAAATGTAAATAACAAAAAACTGAAATCTACCAAAAGAGCATGGAGATTTTTCTTAAATAATAATATT
GTGCTCTCCACCTCACCCTTGTGTAAACCCTCAGGTCAGGTTGGTTCCCCTGGGTCACAAAATGGTAAATGTTCCATACTGACATGCCGG
AGGCAGCCTGACCCGTTATTTGGAAAGAATTTGTGAATTATTTCTGGGTTTGTGTTTTGCCTAAGAGCTGATCTTATTTCTGATTTGTGT
GTGTGTGGTTTATAAATTTTACTACGTGTAACAAAAGTCTGCTTTTCCAGCATGAGCACACTGGAGCCCTCTGCTCACTGGCACTTCCTG
ACTCAAAGGCACTAACAGTGCTCATGTGCCTTCCAGACGGTTCAAGGCAGAGGCCACTGTGCTCAGTGTAGTCTGTGATGAATAGTTTAA
GTGTTCAGAAATTGGTAAACCAACACACGGGATACAATAACTCTCTGTTAACCAGAACACCGTCATTTGACCAAGCCCTACAAGAGTTTA
CCACACTAGATGTTCTGTGAATCCTCGAGTCAGTTCCATTGAGAGGGGCCTGTCTCCAGGGCCAGGCTATTTACTTGGGAAAGTATTTTT
CTTACAGTTCTTGGCCACAGTTTTTTTGCTGAGGGTTTCTGTCTGGGCCTATCAGGTCCATACTTAGACCCTGAGCATCTTCTTCATTCA
GATTTGAATGGCTTATTAAATTAGCACCAAATATCAGTGGGACTGTAGAAGGTAACCGAACACTAGTACCATTGACTCTCGTTGAATAAC
TTTATATTTCCATAATCCTGAATTGTGTAGATAGTTTTCTAGCTCTCGGGTCCCTTTATTGCTTTTTAAAATAGGGTTTGAAACATGCCA
CAGGAAGGTTGCTCTCCAAAAATACACAGTGCAGTGCAAGAAAATGCTATCTCATTGGCCTACTCTCCTATGAATTGCTAAAGTGCCCAC
TTCACATATGTGTTTAAACCTTTATAAACCAGTATTTCACTTTTAAAAAGACAAGGCATCTCTACCCATTAACTCTGCAAGCCACTCCAC
TTGCACCATTCCGCTTGACCCTCCTCTCTCCTGGCTTGGGTCACCAGCCAGGCACCTGTGACACGAGTGCTGCTCTCCAGGATCTCCACT
ACATGTTCCAGGTTGGAGTGAGGACGCGCTATGTGCTCACACTCATGTGACATGACCAAAGATGATACTCTGTAAACAAGGCCCTTCTGA
CCGGACTCAGTGCGTGTGATGGTGAGTGCAATGAGGAAGGGTGGATATTGACTAAAGACTGGTTGTTGTTGTTGTTTAGGTTAGTGTCAC
AGCCATTACAGCACAAGTCAAAGTCGCCAGTTGAATTTTCATTATGCACGTGTGTGGTTTAAGCAGTGGTACTGTTGTATATCATATTGT
AAAGTATCATACTGCCAAGAAAATAACTCCTAGAAAGGCATTATCTCACATCCCCATCTTACTTTCCTACATGTTCTCAAAACACAGTAG
TACCAGCCTTACCTTTCTGCTGTATGTAGATAGTCAGATCATCCTACTGGGGGTGGGATGAATTTAAAAGTTATACCAAAATTTCTGTAA
AGTCTTTGAAAGTCTAGGAGTAGGTGGTCATCTTGTACATTTCAGCAAAGCATCCACTAGGAAACCTCATAGGACAGTGTTAGTGGTTCA
CGTTCTAGTGTTTTTCCTGAAATGTGCAATCTACTGTATAGTATTGCCACATAATTGTACATAGATGTATTCTGAATTTGTGGAATTTCT
TGCTTAGATACTATTGTGTTTGTTTCATATGAATATTTTTGTAATTCTAAAAGAGATCTTATTTAAATTTCCTTTTTAAAAGCCGCATGG
TTCTGTGATCCATGTAACTGACACTTTTTGGCTTTCAGTGCTGTTTAGAAACAGTGGCAAAGGCAGGGTGGTGCTGCCTGCAAGCTGCTG
CCTATGGAAGGCAAAGTCATAGTAATGAGATAGCACCTCTGAACTGTGCAGTCAGCATACCCTGAGTGATGGCTCAGGGGCGCACTACCT
ATTTTGTCACCAGAGCTGACTCAGGCTTCCTGGACCCTCAACCCCAGATCATTCCAGGCAGCATAGCTTTCTTCACAGTCCTTTCAGAAT
TCCCAGGCTGAAATCAGCCATAGCAGTTGACAAAACAGCTATCCCCACAAGTGATGAGATAGTCCCTTTACTGTCCTCAAATGGACTTGG
CCTTAGAGACGTGGTAAAGCACTTTGGCAGGGTTTAAAATATTTGTGAGAAGCCCACATTTCAGTATACATCCTCACTGGCTTCCATGCA
CCCACCTGACGGTAGCCTCACAGAAGTCCTGGCTGTCACTCAGGTGGGGAGCTCATGGTGCCGCTGGGGACTTTTTAGAGAAATGTAAAG
AGAATAGCTATTCAGTGTCTACTAGCAGAGCAACATGTGTCAATTTAACCAAATTCACAAATAACCCTCCATTTTTCAATATCTGCTACT
GTAAACATGAATATTGAATACTGACAAGAGAATACCCATACAAATCGTCCCACCGCCCTAGAGGCCACAGAATTAGCCCAAAATTATCAA
AGAACATTAACTGGAAGGTCAGGTTTTTCAAGGAACATAGCTTACAAATGCATCAGTGTGTATCTGGAGAGCATCCTAACTGCATTTCAA
CTCATCTTTTAAGTGATTTCAGTCAAAACTGGAAAACAACTAAGATGTAGTAATTTTTTTTTCCTGGTTCAAACCTTCAATAACTTGCTC
ATTCAGCAGTCTCTCTGAGCTACATTTTTATTTGTAAAGTGACTCTGTCTGCATGGCAATGAGCAGGTGCGTGTTTTTTCCACATTCGCC
CTTTCTTGCAGTATCCAGGGAAACACATCATTACAAAGGGTTTCTACCTGAAATCTTTCATGGAAGGCCTACAATTCGAAAAGCTGCACA
TGTTTACAGAAGAGCTCTTACCCTCCATGCAAACACTTTGCTCTGTGGTGTCACAGCTTTGTGACAATAAGATGGCAATCTCGGATCTAC
AAGGTGCTGTCGGGAATCAAATAAAATATGTTATCAGAGATATCATCACATCTATAGTGTTTAACAGAGCTTTATGCCAACTACTAAGAC
AAAGCTTTAACAAAGTTTATAGAATACTGAAACTCGTAACAATTACCTCTCTACGTGATGCTGTAAGGAATCTTGCTAATTTGGTAGGAA
GAGGAAGCATTTAGGAAAGGGTTTAGTATCTACCAAAAGTACTTGACCTCAAGTAACCAATAGTAATGCAAACTTGCTTTAAAGGAACCA
AAGGCATTGCCAAGTATTTGCCAAAAGGAGGCACTTTTTATTTAAAATTTGAGACTAATGAGATCTCAAAAATCAGCCCCAAAAAGGTAT
TATCCATTTAAGGTTATAATTTTCACTAAGATGTAGATATTTCTCTTATTGTTTTCATGTAAAATAGTATAGAGTTGTTTTGTTGGTTTA
AGAGTAACATTCAGTAGTAATACAAAGTTTTTTTTCTATGTAGAAATTAGTTTTCTTTTCTTGCTTGCAATAGAAATGCAATGTGATAGG
TGTTTCTCTTCTTATTTTCATTGTCACATTATGTCTTAGCATCTCACTTTATGAAAAAAAGGAGAAAGATACCAATCTACAGAGCCCTGC
TTGTTGAAGCACTAGTTTAATCAACAAAAAATTATGGCAATCGGGGGTCCATTCATCTATTGCCTTTATGTTGTTTTTTAAAAGAAAAAC
CATGATGCCTTTGTATTTGCTGTTTGCACCCCTGAAATCAATTCCATATCATGTTTGAATGCCATACATTTTGCACATGTACTGTACATA
AGTAATGCATACTGTATTTTTATATGTGTGCACATTTATCATCAGATCTTTTGTACATAGTGGCAGTATTGTAGCTGATCGGGAAATGTT

>37802_37802_3_HSP90AB1-MKL2_HSP90AB1_chr6_44220004_ENST00000371646_MKL2_chr16_14354765_ENST00000318282_length(amino acids)=594AA_BP=
MLTITYNPFLFKMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPN
PQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVR
ADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEE
DDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKK
KKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLK
LGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEF

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Fusion Gene PPI Analysis for HSP90AB1-MKL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000353801+1012215_552577.0725.0AHSA1
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371554+1012215_552577.0725.0AHSA1
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371646+1012215_552577.0725.0AHSA1
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000353801+10122_214577.0725.0BIRC2
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371554+10122_214577.0725.0BIRC2
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371646+10122_214577.0725.0BIRC2
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000353801+10129_231577.0725.0NR3C1
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371554+10129_231577.0725.0NR3C1
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371646+10129_231577.0725.0NR3C1
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000353801+10122_527577.0725.0TP53
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371554+10122_527577.0725.0TP53
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371646+10122_527577.0725.0TP53


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000353801+1012620_723577.0725.0NR1D1
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371554+1012620_723577.0725.0NR1D1
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371646+1012620_723577.0725.0NR1D1
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000353801+1012264_608577.0725.0NR3C1
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371554+1012264_608577.0725.0NR3C1
HgeneHSP90AB1chr6:44220004chr16:14354765ENST00000371646+1012264_608577.0725.0NR3C1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSP90AB1-MKL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HSP90AB1-MKL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource