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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HSP90AB1-MYH11 (FusionGDB2 ID:37804)

Fusion Gene Summary for HSP90AB1-MYH11

check button Fusion gene summary
Fusion gene informationFusion gene name: HSP90AB1-MYH11
Fusion gene ID: 37804
HgeneTgene
Gene symbol

HSP90AB1

MYH11

Gene ID

3326

4629

Gene nameheat shock protein 90 alpha family class B member 1myosin heavy chain 11
SynonymsD6S182|HSP84|HSP90B|HSPC2|HSPCBAAT4|FAA4|SMHC|SMMHC
Cytomap

6p21.1

16p13.11

Type of geneprotein-codingprotein-coding
Descriptionheat shock protein HSP 90-betaHSP90-betaheat shock 84 kDaheat shock 90kD protein 1, betaheat shock protein 90 kDaheat shock protein 90kDa alpha (cytosolic), class B member 1heat shock protein 90kDa alpha family class B member 1myosin-11epididymis secretory sperm binding proteinmyosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth muscle
Modification date2020032720200322
UniProtAcc

P08238

P35749

Ensembl transtripts involved in fusion geneENST00000353801, ENST00000371554, 
ENST00000371646, 		ENST00000573908, 
ENST00000300036, ENST00000396324, 
ENST00000452625, ENST00000576790, 
Fusion gene scores* DoF score20 X 20 X 7=280044 X 55 X 10=24200
# samples 2262
** MAII scorelog2(22/2800*10)=-3.66985139830767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(62/24200*10)=-5.28659502177508
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSP90AB1 [Title/Abstract] AND MYH11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSP90AB1(44218074)-MYH11(15815477), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSP90AB1

GO:0007004

telomere maintenance via telomerase

10197982

HgeneHSP90AB1

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

24613385

HgeneHSP90AB1

GO:0031396

regulation of protein ubiquitination

16809764

HgeneHSP90AB1

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

24613385

HgeneHSP90AB1

GO:0032516

positive regulation of phosphoprotein phosphatase activity

26593036

HgeneHSP90AB1

GO:0051131

chaperone-mediated protein complex assembly

10811660

HgeneHSP90AB1

GO:0051973

positive regulation of telomerase activity

10197982

HgeneHSP90AB1

GO:1901389

negative regulation of transforming growth factor beta activation

20599762

HgeneHSP90AB1

GO:1905323

telomerase holoenzyme complex assembly

10197982

HgeneHSP90AB1

GO:2000010

positive regulation of protein localization to cell surface

23431407


check buttonFusion gene breakpoints across HSP90AB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYH11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8384-01AHSP90AB1chr6

44218074

+MYH11chr16

15815477

-


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Fusion Gene ORF analysis for HSP90AB1-MYH11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000353801ENST00000573908HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
5CDS-intronENST00000371554ENST00000573908HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
5CDS-intronENST00000371646ENST00000573908HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
In-frameENST00000353801ENST00000300036HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
In-frameENST00000353801ENST00000396324HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
In-frameENST00000353801ENST00000452625HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
In-frameENST00000353801ENST00000576790HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
In-frameENST00000371554ENST00000300036HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
In-frameENST00000371554ENST00000396324HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
In-frameENST00000371554ENST00000452625HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
In-frameENST00000371554ENST00000576790HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
In-frameENST00000371646ENST00000300036HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
In-frameENST00000371646ENST00000396324HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
In-frameENST00000371646ENST00000452625HSP90AB1chr6

44218074

+MYH11chr16

15815477

-
In-frameENST00000371646ENST00000576790HSP90AB1chr6

44218074

+MYH11chr16

15815477

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000353801HSP90AB1chr644218074+ENST00000396324MYH11chr1615815477-3391103227961906296
ENST00000353801HSP90AB1chr644218074+ENST00000452625MYH11chr1615815477-3430103228351906309
ENST00000353801HSP90AB1chr644218074+ENST00000576790MYH11chr1615815477-2815103222311173352
ENST00000353801HSP90AB1chr644218074+ENST00000300036MYH11chr1615815477-257210321988918356
ENST00000371646HSP90AB1chr644218074+ENST00000396324MYH11chr1615815477-3378101927831893296
ENST00000371646HSP90AB1chr644218074+ENST00000452625MYH11chr1615815477-3417101928221893309
ENST00000371646HSP90AB1chr644218074+ENST00000576790MYH11chr1615815477-2802101922181160352
ENST00000371646HSP90AB1chr644218074+ENST00000300036MYH11chr1615815477-255910191975905356
ENST00000371554HSP90AB1chr644218074+ENST00000396324MYH11chr1615815477-3483112428881998296
ENST00000371554HSP90AB1chr644218074+ENST00000452625MYH11chr1615815477-3522112429271998309
ENST00000371554HSP90AB1chr644218074+ENST00000576790MYH11chr1615815477-2907112423231265352
ENST00000371554HSP90AB1chr644218074+ENST00000300036MYH11chr1615815477-2664112420801010356

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353801ENST00000396324HSP90AB1chr644218074+MYH11chr1615815477-0.0040850810.9959149
ENST00000353801ENST00000452625HSP90AB1chr644218074+MYH11chr1615815477-0.0014157740.9985843
ENST00000353801ENST00000576790HSP90AB1chr644218074+MYH11chr1615815477-0.0012487870.99875116
ENST00000353801ENST00000300036HSP90AB1chr644218074+MYH11chr1615815477-0.0032940260.99670595
ENST00000371646ENST00000396324HSP90AB1chr644218074+MYH11chr1615815477-0.0041012630.99589866
ENST00000371646ENST00000452625HSP90AB1chr644218074+MYH11chr1615815477-0.0014400650.9985599
ENST00000371646ENST00000576790HSP90AB1chr644218074+MYH11chr1615815477-0.001493710.99850625
ENST00000371646ENST00000300036HSP90AB1chr644218074+MYH11chr1615815477-0.0029045870.99709547
ENST00000371554ENST00000396324HSP90AB1chr644218074+MYH11chr1615815477-0.0039496590.9960503
ENST00000371554ENST00000452625HSP90AB1chr644218074+MYH11chr1615815477-0.0012944250.9987056
ENST00000371554ENST00000576790HSP90AB1chr644218074+MYH11chr1615815477-0.0014483860.99855155
ENST00000371554ENST00000300036HSP90AB1chr644218074+MYH11chr1615815477-0.002823040.997177

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Fusion Genomic Features for HSP90AB1-MYH11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HSP90AB1-MYH11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:44218074/chr16:15815477)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSP90AB1

P08238

MYH11

P35749

FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.FUNCTION: Muscle contraction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYH11chr6:44218074chr16:15815477ENST00000300036041844_193401973.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr6:44218074chr16:15815477ENST00000396324042844_193401980.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr6:44218074chr16:15815477ENST00000452625043844_193402132.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr6:44218074chr16:15815477ENST00000576790042844_193401912.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr6:44218074chr16:15815477ENST0000030003604131_8101973.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr6:44218074chr16:15815477ENST00000300036041786_81501973.0DomainIQ
TgeneMYH11chr6:44218074chr16:15815477ENST0000030003604185_78301973.0DomainMyosin motor
TgeneMYH11chr6:44218074chr16:15815477ENST0000039632404231_8101980.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr6:44218074chr16:15815477ENST00000396324042786_81501980.0DomainIQ
TgeneMYH11chr6:44218074chr16:15815477ENST0000039632404285_78301980.0DomainMyosin motor
TgeneMYH11chr6:44218074chr16:15815477ENST0000045262504331_8102132.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr6:44218074chr16:15815477ENST00000452625043786_81502132.0DomainIQ
TgeneMYH11chr6:44218074chr16:15815477ENST0000045262504385_78302132.0DomainMyosin motor
TgeneMYH11chr6:44218074chr16:15815477ENST0000057679004231_8101912.6666666666667DomainMyosin N-terminal SH3-like
TgeneMYH11chr6:44218074chr16:15815477ENST00000576790042786_81501912.6666666666667DomainIQ
TgeneMYH11chr6:44218074chr16:15815477ENST0000057679004285_78301912.6666666666667DomainMyosin motor
TgeneMYH11chr6:44218074chr16:15815477ENST00000300036041178_18501973.0Nucleotide bindingATP
TgeneMYH11chr6:44218074chr16:15815477ENST00000396324042178_18501980.0Nucleotide bindingATP
TgeneMYH11chr6:44218074chr16:15815477ENST00000452625043178_18502132.0Nucleotide bindingATP
TgeneMYH11chr6:44218074chr16:15815477ENST00000576790042178_18501912.6666666666667Nucleotide bindingATP
TgeneMYH11chr6:44218074chr16:15815477ENST000003000360411935_197201973.0RegionNote=C-terminal
TgeneMYH11chr6:44218074chr16:15815477ENST00000300036041661_68301973.0RegionActin-binding
TgeneMYH11chr6:44218074chr16:15815477ENST00000300036041762_77601973.0RegionActin-binding
TgeneMYH11chr6:44218074chr16:15815477ENST000003963240421935_197201980.0RegionNote=C-terminal
TgeneMYH11chr6:44218074chr16:15815477ENST00000396324042661_68301980.0RegionActin-binding
TgeneMYH11chr6:44218074chr16:15815477ENST00000396324042762_77601980.0RegionActin-binding
TgeneMYH11chr6:44218074chr16:15815477ENST000004526250431935_197202132.0RegionNote=C-terminal
TgeneMYH11chr6:44218074chr16:15815477ENST00000452625043661_68302132.0RegionActin-binding
TgeneMYH11chr6:44218074chr16:15815477ENST00000452625043762_77602132.0RegionActin-binding
TgeneMYH11chr6:44218074chr16:15815477ENST000005767900421935_197201912.6666666666667RegionNote=C-terminal
TgeneMYH11chr6:44218074chr16:15815477ENST00000576790042661_68301912.6666666666667RegionActin-binding
TgeneMYH11chr6:44218074chr16:15815477ENST00000576790042762_77601912.6666666666667RegionActin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000353801+112720_7240725.0MotifNote=TPR repeat-binding
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371554+112720_7240725.0MotifNote=TPR repeat-binding
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371646+112720_7240725.0MotifNote=TPR repeat-binding


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Fusion Gene Sequence for HSP90AB1-MYH11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37804_37804_1_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000353801_MYH11_chr16_15815477_ENST00000300036_length(transcript)=2572nt_BP=1032nt
GGCACGCAGTAGCTCTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTA
TAATCCTTTTCTTTTCAAGATTTTTATTTTAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAG
AAATTGCCCAACTCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATG
CCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCCTC
AGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTA
CTAAAGCATTCATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGG
CAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTG
ACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAG
AAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAA
GAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAA
TACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTAC
AAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGGCGAGGAAACGAGACCTCTTTCGTTCCTTCTAGAAGGTCTGGAGGACG
TAGAGTTATTGAAAATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTTCAATGGAACCAAGGCCAGTGAATAAGCAGA
GAAAGGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTGGAGGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAACCGCAGGAAGCT
GCAGCGGGAGCTGGATGAGGCCACGGAGAGCAACGAGGCCATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGAGAGAAACAGGC
GGCCACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAGGAAATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTACAA
GGAGCAGGCCGAGCAGCTCAGCAACGAGCTGGCCACAGAGCGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGGCA
GAACAAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGGGCCGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTGGAGGCCAAGAT
TGCACAGCTGGAGGAGCAGGTCGAGCAGGAGGCCAGGAACGCACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATCGCCCAGCTGGA
GGAGGAGCTGGAGGAGGAGCAGGGCAACATGGAGGCCATGAGCGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCCGCCGCTGAGAG
GGCTCGCAAACAAGCGGACCTCGAGAAGGAGGAACTGGCAGAGGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGAAGGACTTTCAA
AGAGAGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCTTTGCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAGAC
CTCATGCAGCTACAAGAGCTTCACGAGTATGAGACGGAACTGGAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAGCAAAGAAGAAG
CTGGAAGGGGACCTGAAAGACCTGGAGCTTCAGGCCGACTCTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTGCAG
GTCCATGAGCTGGAGAAGTCCAAGCGGGCCCTGGAGACCCAGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGACGAGCTGCAA
GCCACGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGCAGGCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAGCAG
AATGAGGAGAAGAGGAGGCAACTGCAGAGACAGGAAAAACATCTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAGGCAGAAGCCAG
GGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTTGAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATGCT

>37804_37804_1_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000353801_MYH11_chr16_15815477_ENST00000300036_length(amino acids)=356AA_BP=
MHEVCFQALGFLLILFGCGKDLISGGTGIFQLSLKVLHLSLPDRLLASSSASSSFSRSACLRALSAAARSCCVALRTRSLMASMLPCSSS
SSSSSWAIRASRRRFSSWSAFLASCSTCSSSCAILASSAAMVDLNLDLTAPSISWSLLRSSLFCRSSCCRALSFFWAVLRSVASSLLSCS
ACSLYCSAILRSSSTCSKISFSFLSFCFSDLVAACFSLSLLLSAFTSRPMASLLSVASSSSRCSFLRLALMRWDSSSASSSCLLSCLTLA

--------------------------------------------------------------
>37804_37804_2_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000353801_MYH11_chr16_15815477_ENST00000396324_length(transcript)=3391nt_BP=1032nt
GGCACGCAGTAGCTCTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTA
TAATCCTTTTCTTTTCAAGATTTTTATTTTAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAG
AAATTGCCCAACTCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATG
CCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCCTC
AGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTA
CTAAAGCATTCATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGG
CAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTG
ACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAG
AAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAA
GAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAA
TACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTAC
AAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGGCGAGGAAACGAGACCTCTTTCGTTCCTTCTAGAAGGTCTGGAGGACG
TAGAGTTATTGAAAATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTTCAATGGAACCAAGGCCAGTGAATAAGCAAC
TTTCTACAGTTTTGCACCACGGCAAGAAAACCAAAAACCAAAACAAACAAACAAAAAAAACCCAACAACAACCCAGAACAAAGCAAAACC
CAGCAGACTGTACTTAGCATTGTCTAAATCCATTCTCAAATTCCAAATATCACAGACACCCCTCACACAAGGAATATAAAAACCACCACC
CTCCAGCCTGGGCAACGTAGTAAAACCTCATCTATACAAGAATTTAAAAATAAGCTGGGCGTGGTGGTACACACCTGTGGTCCCAGCTAC
TAGGGAGGCTGAGCCAGGAAGAACGCTCCAGCCCAGGACTTCGAGGCTGCAATGAGCTATAATTGCATCATTGCACTCCAGCCTGGGCAA
CAGAGACCCTGTCTCAACCACCACCACCACCACCACCCCTACTACCCCTGTATTCAAGGTAAAAATTGAAGTTTGTATGATGTAAGAGAT
GAGAAAAACCCAACAGGAAACACAGACACATCCTCCAGTTCTATCAATGGATTGTGCAGACACTGAGTTTTTAGAAAAACATATCCACGG
TAACCGGTCCCTGGCAATTCTGTTTACATGAAATGGGGAGAAAGTCACCGAAATGGGTGCCGCCGGCCCCCACTCCCAATTCATTCCCTA
ACCTGCAAACCTTTCCAACTTCTCACGTCAGGCCTTTGAGAATTCTTTCCCCCTCTCCTGGTTTCCACACCTCAGACACGCACAGTTCAC
CAAGTGCCTTCTGTAGTCACATGAATTGAAAAGGAGACGCTGCTCCCACGGAGGGGAGCAGGAATGCTGCACTGTTTACACCCTGACTGT
GCTTGCAGAGAAAGGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTGGAGGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAACCG
CAGGAAGCTGCAGCGGGAGCTGGATGAGGCCACGGAGAGCAACGAGGCCATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGAGA
GAAACAGGCGGCCACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAGGAAATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGA
GCAGTACAAGGAGCAGGCCGAGCAGCTCAGCAACGAGCTGGCCACAGAGCGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCT
CGAGCGGCAGAACAAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGGGCCGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTGGA
GGCCAAGATTGCACAGCTGGAGGAGCAGGTCGAGCAGGAGGCCAGGAACGCACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATCGC
CCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGCAACATGGAGGCCATGAGCGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCCGC
CGCTGAGAGGGCTCGCAAACAAGCGGACCTCGAGAAGGAGGAACTGGCAGAGGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGAAG
GACTTTCAAAGAGAGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCTTTGCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTG
GAAGCAGACCTCATGCAGCTACAAGAGCTTCACGAGTATGAGACGGAACTGGAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAGCA
AAGAAGAAGCTGGAAGGGGACCTGAAAGACCTGGAGCTTCAGGCCGACTCTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGC
AAACTGCAGGTCCATGAGCTGGAGAAGTCCAAGCGGGCCCTGGAGACCCAGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGAC
GAGCTGCAAGCCACGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGCAGGCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCCGG
GACGAGCAGAATGAGGAGAAGAGGAGGCAACTGCAGAGACAGGAAAAACATCTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAGGC
AGAAGCCAGGGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTTGAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAA

>37804_37804_2_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000353801_MYH11_chr16_15815477_ENST00000396324_length(amino acids)=296AA_BP=36
MLPSSWLSSHSLWLWQRSHLWRHGHLPALFESPSSEPSRQATGQLLCQFLLLEVRLFASPLSGGEVLLCGFADPVAHGLHVALLLLQLLL
QLGDPGLQAALLVLECVPGLLLDLLLQLCNLGLQRRDGGLELGLDGPLHLVELAPELLVLPLELLPGTLILLGRAALCGQLVAELLGLLL
VLLGHLALVLHLQQDFLQLLVFLLQRLGGRLFLSELALECVHLAAHGLVALRGLIQLPLQLPAVGVDALGLLLCLLQLPLELLDPGIAFL

--------------------------------------------------------------
>37804_37804_3_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000353801_MYH11_chr16_15815477_ENST00000452625_length(transcript)=3430nt_BP=1032nt
GGCACGCAGTAGCTCTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTA
TAATCCTTTTCTTTTCAAGATTTTTATTTTAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAG
AAATTGCCCAACTCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATG
CCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCCTC
AGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTA
CTAAAGCATTCATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGG
CAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTG
ACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAG
AAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAA
GAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAA
TACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTAC
AAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGGCGAGGAAACGAGACCTCTTTCGTTCCTTCTAGAAGGTCTGGAGGACG
TAGAGTTATTGAAAATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTTCAATGGAACCAAGGCCAGTGAATAAGCAAC
TTTCTACAGTTTTGCACCACGGCAAGAAAACCAAAAACCAAAACAAACAAACAAAAAAAACCCAACAACAACCCAGAACAAAGCAAAACC
CAGCAGACTGTACTTAGCATTGTCTAAATCCATTCTCAAATTCCAAATATCACAGACACCCCTCACACAAGGAATATAAAAACCACCACC
CTCCAGCCTGGGCAACGTAGTAAAACCTCATCTATACAAGAATTTAAAAATAAGCTGGGCGTGGTGGTACACACCTGTGGTCCCAGCTAC
TAGGGAGGCTGAGCCAGGAAGAACGCTCCAGCCCAGGACTTCGAGGCTGCAATGAGCTATAATTGCATCATTGCACTCCAGCCTGGGCAA
CAGAGACCCTGTCTCAACCACCACCACCACCACCACCCCTACTACCCCTGTATTCAAGGTAAAAATTGAAGTTTGTATGATGTAAGAGAT
GAGAAAAACCCAACAGGAAACACAGACACATCCTCCAGTTCTATCAATGGATTGTGCAGACACTGAGTTTTTAGAAAAACATATCCACGG
TAACCGGTCCCTGGCAATTCTGTTTACATGAAATGGGGAGAAAGTCACCGAAATGGGTGCCGCCGGCCCCCACTCCCAATTCATTCCCTA
ACCTGCAAACCTTTCCAACTTCTCACGTCAGGCCTTTGAGAATTCTTTCCCCCTCTCCTGGTTTCCACACCTCAGACACGCACAGTTCAC
CAAGTGCCTTCTGTAGTCACATGAATTGAAAAGGAGACGCTGCTCCCACGGAGGGGAGCAGGAATGCTGCACTGTTTACACCCTGACTGT
GCTTAGGGCCCCCCCCACAGGAAACTTCGCAGTGATGCACCAGGCAGAGAAAGGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTGGA
GGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAACCGCAGGAAGCTGCAGCGGGAGCTGGATGAGGCCACGGAGAGCAACGAGGCCAT
GGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGAGAGAAACAGGCGGCCACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAGGA
AATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTACAAGGAGCAGGCCGAGCAGCTCAGCAACGAGCTGGCCACAGAGCG
CAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGGCAGAACAAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGGGC
CGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTGGAGGCCAAGATTGCACAGCTGGAGGAGCAGGTCGAGCAGGAGGCCAGGAACGC
ACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATCGCCCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGCAACATGGAGGCCATGAG
CGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCCGCCGCTGAGAGGGCTCGCAAACAAGCGGACCTCGAGAAGGAGGAACTGGCAGA
GGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGAAGGACTTTCAAAGAGAGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCTTT
GCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAGACCTCATGCAGCTACAAGAGCTTCACGAGTATGAGACGGAACTG
GAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAGCAAAGAAGAAGCTGGAAGGGGACCTGAAAGACCTGGAGCTTCAGGCCGACTCT
GCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTGCAGGTCCATGAGCTGGAGAAGTCCAAGCGGGCCCTGGAGACCCAG
ATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGACGAGCTGCAAGCCACGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGCAG
GCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAGCAGAATGAGGAGAAGAGGAGGCAACTGCAGAGACAGGAAAAACAT
CTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAGGCAGAAGCCAGGGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTTGA
AGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATGCTCAAAGCCGAAATGGAAGACCTGGTCAGCTCCAAGGATGACGT

>37804_37804_3_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000353801_MYH11_chr16_15815477_ENST00000452625_length(amino acids)=309AA_BP=36
MLPSSWLSSHSLWLWQRSHLWRHGHLPALFESPSSEPSRQATGQLLCQFLLLEVRLFASPLSGGEVLLCGFADPVAHGLHVALLLLQLLL
QLGDPGLQAALLVLECVPGLLLDLLLQLCNLGLQRRDGGLELGLDGPLHLVELAPELLVLPLELLPGTLILLGRAALCGQLVAELLGLLL
VLLGHLALVLHLQQDFLQLLVFLLQRLGGRLFLSELALECVHLAAHGLVALRGLIQLPLQLPAVGVDALGLLLCLLQLPLELLDPGIAFL

--------------------------------------------------------------
>37804_37804_4_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000353801_MYH11_chr16_15815477_ENST00000576790_length(transcript)=2815nt_BP=1032nt
GGCACGCAGTAGCTCTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTA
TAATCCTTTTCTTTTCAAGATTTTTATTTTAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAG
AAATTGCCCAACTCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATG
CCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCCTC
AGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTA
CTAAAGCATTCATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGG
CAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTG
ACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAG
AAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAA
GAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAA
TACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTAC
AAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGGCGAGGAAACGAGACCTCTTTCGTTCCTTCTAGAAGGTCTGGAGGACG
TAGAGTTATTGAAAATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTTCAATGGAACCAAGGCCAGTGAATAAGCAAC
TTTCTACAGTTTTGCACCACGGCAAGAAAACCAAAAACCAAAACAAACAAACAAAAAAAACCCAACAACAACCCAGAACAAAGCAAAACC
CAGCAGACTGTACTTAGCATTGTCTAAATCCATTCTCAAATTCCAAATATCACAGACACCCCTCACACAAGGAATATAAAAACCACCACC
CTCCAGCCTGGGCAACGTAAGGGCCCCCCCCACAGGAAACTTCGCAGTGATGCACCAGGCAGAGAAAGGCAATGCCAGGGTCAAGCAGCT
CAAGAGGCAGCTGGAGGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAACCGCAGGAAGCTGCAGCGGGAGCTGGATGAGGCCACGGA
GAGCAACGAGGCCATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGAGAGAAACAGGCGGCCACCAAGTCGCTGAAGCAGAAAGA
CAAGAAGCTGAAGGAAATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTACAAGGAGCAGGCCGAGCAGCTCAGCAACGA
GCTGGCCACAGAGCGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGGCAGAACAAGGAGCTCCGGAGCAAGCTCCA
CGAGATGGAGGGGGCCGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTGGAGGCCAAGATTGCACAGCTGGAGGAGCAGGTCGAGCA
GGAGGCCAGGAACGCACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATCGCCCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGCAA
CATGGAGGCCATGAGCGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCCGCCGCTGAGAGGGCTCGCAAACAAGCGGACCTCGAGAA
GGAGGAACTGGCAGAGGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGAAGGACTTTCAAAGAGAGCTGGAAGATGCCCGTGCCTCC
AGAGATGAGATCTTTGCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAGACCTCATGCAGCTACAAGAGCTTCACGAG
TATGAGACGGAACTGGAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAGCAAAGAAGAAGCTGGAAGGGGACCTGAAAGACCTGGAG
CTTCAGGCCGACTCTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTGCAGGTCCATGAGCTGGAGAAGTCCAAGCGG
GCCCTGGAGACCCAGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGACGAGCTGCAAGCCACGGAGGACGCCAAACTGCGGCTG
GAAGTCAACATGCAGGCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAGCAGAATGAGGAGAAGAGGAGGCAACTGCAG
AGACAGGAAAAACATCTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAGGCAGAAGCCAGGGAGAAGGAAACCAAGGCCCTGTCCCT
GGCTCGGGCCCTTGAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATGCTCAAAGCCGAAATGGAAGACCTGGTCAG

>37804_37804_4_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000353801_MYH11_chr16_15815477_ENST00000576790_length(amino acids)=352AA_BP=
MHEVCFQALGFLLILFGCGKDLISGGTGIFQLSLKVLHLSLPDRLLASSSASSSFSRSACLRALSAAARSCCVALRTRSLMASMLPCSSS
SSSSSWAIRASRRRFSSWSAFLASCSTCSSSCAILASSAAMVDLNLDLTAPSISWSLLRSSLFCRSSCCRALSFFWAVLRSVASSLLSCS
ACSLYCSAILRSSSTCSKISFSFLSFCFSDLVAACFSLSLLLSAFTSRPMASLLSVASSSSRCSFLRLALMRWDSSSASSSCLLSCLTLA

--------------------------------------------------------------
>37804_37804_5_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371554_MYH11_chr16_15815477_ENST00000300036_length(transcript)=2664nt_BP=1124nt
GTGCCCGGATGCTGGGGCGAGGGAGGGTGCACTGCGGCGCCCCCTCCTCGCGTGGTCCTGGCCGACGCATGTCCGGCAGTGACGAGTGTC
GGCCTGGTGGCTACGGCCACCATCTTTCTTGGGTTTGGTCCTGTTCTGTAATTTTGTGCTGTGAAAGGGTCGTGGTGGAGCTTTTGGCTT
AAGAATTCTTTGTCCGGATTTAATTGCTCCTCCGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGC
AGAAATTGCCCAACTCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGA
TGCCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCC
TCAGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGG
TACTAAAGCATTCATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGT
GGCAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGC
TGACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAA
AGAAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATG
AAGAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGA
AATACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCT
ACAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGGCGAGGAAACGAGACCTCTTTCGTTCCTTCTAGAAGGTCTGGAGGA
CGTAGAGTTATTGAAAATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTTCAATGGAACCAAGGCCAGTGAATAAGCA
GAGAAAGGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTGGAGGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAACCGCAGGAAG
CTGCAGCGGGAGCTGGATGAGGCCACGGAGAGCAACGAGGCCATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGAGAGAAACAG
GCGGCCACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAGGAAATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTAC
AAGGAGCAGGCCGAGCAGCTCAGCAACGAGCTGGCCACAGAGCGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGG
CAGAACAAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGGGCCGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTGGAGGCCAAG
ATTGCACAGCTGGAGGAGCAGGTCGAGCAGGAGGCCAGGAACGCACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATCGCCCAGCTG
GAGGAGGAGCTGGAGGAGGAGCAGGGCAACATGGAGGCCATGAGCGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCCGCCGCTGAG
AGGGCTCGCAAACAAGCGGACCTCGAGAAGGAGGAACTGGCAGAGGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGAAGGACTTTC
AAAGAGAGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCTTTGCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAG
ACCTCATGCAGCTACAAGAGCTTCACGAGTATGAGACGGAACTGGAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAGCAAAGAAGA
AGCTGGAAGGGGACCTGAAAGACCTGGAGCTTCAGGCCGACTCTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTGC
AGGTCCATGAGCTGGAGAAGTCCAAGCGGGCCCTGGAGACCCAGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGACGAGCTGC
AAGCCACGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGCAGGCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAGC
AGAATGAGGAGAAGAGGAGGCAACTGCAGAGACAGGAAAAACATCTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAGGCAGAAGCC
AGGGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTTGAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATG

>37804_37804_5_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371554_MYH11_chr16_15815477_ENST00000300036_length(amino acids)=356AA_BP=
MHEVCFQALGFLLILFGCGKDLISGGTGIFQLSLKVLHLSLPDRLLASSSASSSFSRSACLRALSAAARSCCVALRTRSLMASMLPCSSS
SSSSSWAIRASRRRFSSWSAFLASCSTCSSSCAILASSAAMVDLNLDLTAPSISWSLLRSSLFCRSSCCRALSFFWAVLRSVASSLLSCS
ACSLYCSAILRSSSTCSKISFSFLSFCFSDLVAACFSLSLLLSAFTSRPMASLLSVASSSSRCSFLRLALMRWDSSSASSSCLLSCLTLA

--------------------------------------------------------------
>37804_37804_6_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371554_MYH11_chr16_15815477_ENST00000396324_length(transcript)=3483nt_BP=1124nt
GTGCCCGGATGCTGGGGCGAGGGAGGGTGCACTGCGGCGCCCCCTCCTCGCGTGGTCCTGGCCGACGCATGTCCGGCAGTGACGAGTGTC
GGCCTGGTGGCTACGGCCACCATCTTTCTTGGGTTTGGTCCTGTTCTGTAATTTTGTGCTGTGAAAGGGTCGTGGTGGAGCTTTTGGCTT
AAGAATTCTTTGTCCGGATTTAATTGCTCCTCCGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGC
AGAAATTGCCCAACTCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGA
TGCCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCC
TCAGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGG
TACTAAAGCATTCATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGT
GGCAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGC
TGACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAA
AGAAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATG
AAGAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGA
AATACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCT
ACAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGGCGAGGAAACGAGACCTCTTTCGTTCCTTCTAGAAGGTCTGGAGGA
CGTAGAGTTATTGAAAATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTTCAATGGAACCAAGGCCAGTGAATAAGCA
ACTTTCTACAGTTTTGCACCACGGCAAGAAAACCAAAAACCAAAACAAACAAACAAAAAAAACCCAACAACAACCCAGAACAAAGCAAAA
CCCAGCAGACTGTACTTAGCATTGTCTAAATCCATTCTCAAATTCCAAATATCACAGACACCCCTCACACAAGGAATATAAAAACCACCA
CCCTCCAGCCTGGGCAACGTAGTAAAACCTCATCTATACAAGAATTTAAAAATAAGCTGGGCGTGGTGGTACACACCTGTGGTCCCAGCT
ACTAGGGAGGCTGAGCCAGGAAGAACGCTCCAGCCCAGGACTTCGAGGCTGCAATGAGCTATAATTGCATCATTGCACTCCAGCCTGGGC
AACAGAGACCCTGTCTCAACCACCACCACCACCACCACCCCTACTACCCCTGTATTCAAGGTAAAAATTGAAGTTTGTATGATGTAAGAG
ATGAGAAAAACCCAACAGGAAACACAGACACATCCTCCAGTTCTATCAATGGATTGTGCAGACACTGAGTTTTTAGAAAAACATATCCAC
GGTAACCGGTCCCTGGCAATTCTGTTTACATGAAATGGGGAGAAAGTCACCGAAATGGGTGCCGCCGGCCCCCACTCCCAATTCATTCCC
TAACCTGCAAACCTTTCCAACTTCTCACGTCAGGCCTTTGAGAATTCTTTCCCCCTCTCCTGGTTTCCACACCTCAGACACGCACAGTTC
ACCAAGTGCCTTCTGTAGTCACATGAATTGAAAAGGAGACGCTGCTCCCACGGAGGGGAGCAGGAATGCTGCACTGTTTACACCCTGACT
GTGCTTGCAGAGAAAGGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTGGAGGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAAC
CGCAGGAAGCTGCAGCGGGAGCTGGATGAGGCCACGGAGAGCAACGAGGCCATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGA
GAGAAACAGGCGGCCACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAGGAAATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCC
GAGCAGTACAAGGAGCAGGCCGAGCAGCTCAGCAACGAGCTGGCCACAGAGCGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAG
CTCGAGCGGCAGAACAAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGGGCCGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTG
GAGGCCAAGATTGCACAGCTGGAGGAGCAGGTCGAGCAGGAGGCCAGGAACGCACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATC
GCCCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGCAACATGGAGGCCATGAGCGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCC
GCCGCTGAGAGGGCTCGCAAACAAGCGGACCTCGAGAAGGAGGAACTGGCAGAGGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGA
AGGACTTTCAAAGAGAGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCTTTGCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCT
TGGAAGCAGACCTCATGCAGCTACAAGAGCTTCACGAGTATGAGACGGAACTGGAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAG
CAAAGAAGAAGCTGGAAGGGGACCTGAAAGACCTGGAGCTTCAGGCCGACTCTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTAC
GCAAACTGCAGGTCCATGAGCTGGAGAAGTCCAAGCGGGCCCTGGAGACCCAGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGG
ACGAGCTGCAAGCCACGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGCAGGCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCC
GGGACGAGCAGAATGAGGAGAAGAGGAGGCAACTGCAGAGACAGGAAAAACATCTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAG
GCAGAAGCCAGGGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTTGAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACC

>37804_37804_6_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371554_MYH11_chr16_15815477_ENST00000396324_length(amino acids)=296AA_BP=36
MLPSSWLSSHSLWLWQRSHLWRHGHLPALFESPSSEPSRQATGQLLCQFLLLEVRLFASPLSGGEVLLCGFADPVAHGLHVALLLLQLLL
QLGDPGLQAALLVLECVPGLLLDLLLQLCNLGLQRRDGGLELGLDGPLHLVELAPELLVLPLELLPGTLILLGRAALCGQLVAELLGLLL
VLLGHLALVLHLQQDFLQLLVFLLQRLGGRLFLSELALECVHLAAHGLVALRGLIQLPLQLPAVGVDALGLLLCLLQLPLELLDPGIAFL

--------------------------------------------------------------
>37804_37804_7_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371554_MYH11_chr16_15815477_ENST00000452625_length(transcript)=3522nt_BP=1124nt
GTGCCCGGATGCTGGGGCGAGGGAGGGTGCACTGCGGCGCCCCCTCCTCGCGTGGTCCTGGCCGACGCATGTCCGGCAGTGACGAGTGTC
GGCCTGGTGGCTACGGCCACCATCTTTCTTGGGTTTGGTCCTGTTCTGTAATTTTGTGCTGTGAAAGGGTCGTGGTGGAGCTTTTGGCTT
AAGAATTCTTTGTCCGGATTTAATTGCTCCTCCGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGC
AGAAATTGCCCAACTCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGA
TGCCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCC
TCAGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGG
TACTAAAGCATTCATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGT
GGCAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGC
TGACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAA
AGAAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATG
AAGAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGA
AATACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCT
ACAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGGCGAGGAAACGAGACCTCTTTCGTTCCTTCTAGAAGGTCTGGAGGA
CGTAGAGTTATTGAAAATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTTCAATGGAACCAAGGCCAGTGAATAAGCA
ACTTTCTACAGTTTTGCACCACGGCAAGAAAACCAAAAACCAAAACAAACAAACAAAAAAAACCCAACAACAACCCAGAACAAAGCAAAA
CCCAGCAGACTGTACTTAGCATTGTCTAAATCCATTCTCAAATTCCAAATATCACAGACACCCCTCACACAAGGAATATAAAAACCACCA
CCCTCCAGCCTGGGCAACGTAGTAAAACCTCATCTATACAAGAATTTAAAAATAAGCTGGGCGTGGTGGTACACACCTGTGGTCCCAGCT
ACTAGGGAGGCTGAGCCAGGAAGAACGCTCCAGCCCAGGACTTCGAGGCTGCAATGAGCTATAATTGCATCATTGCACTCCAGCCTGGGC
AACAGAGACCCTGTCTCAACCACCACCACCACCACCACCCCTACTACCCCTGTATTCAAGGTAAAAATTGAAGTTTGTATGATGTAAGAG
ATGAGAAAAACCCAACAGGAAACACAGACACATCCTCCAGTTCTATCAATGGATTGTGCAGACACTGAGTTTTTAGAAAAACATATCCAC
GGTAACCGGTCCCTGGCAATTCTGTTTACATGAAATGGGGAGAAAGTCACCGAAATGGGTGCCGCCGGCCCCCACTCCCAATTCATTCCC
TAACCTGCAAACCTTTCCAACTTCTCACGTCAGGCCTTTGAGAATTCTTTCCCCCTCTCCTGGTTTCCACACCTCAGACACGCACAGTTC
ACCAAGTGCCTTCTGTAGTCACATGAATTGAAAAGGAGACGCTGCTCCCACGGAGGGGAGCAGGAATGCTGCACTGTTTACACCCTGACT
GTGCTTAGGGCCCCCCCCACAGGAAACTTCGCAGTGATGCACCAGGCAGAGAAAGGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTG
GAGGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAACCGCAGGAAGCTGCAGCGGGAGCTGGATGAGGCCACGGAGAGCAACGAGGCC
ATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGAGAGAAACAGGCGGCCACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAG
GAAATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTACAAGGAGCAGGCCGAGCAGCTCAGCAACGAGCTGGCCACAGAG
CGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGGCAGAACAAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGG
GCCGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTGGAGGCCAAGATTGCACAGCTGGAGGAGCAGGTCGAGCAGGAGGCCAGGAAC
GCACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATCGCCCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGCAACATGGAGGCCATG
AGCGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCCGCCGCTGAGAGGGCTCGCAAACAAGCGGACCTCGAGAAGGAGGAACTGGCA
GAGGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGAAGGACTTTCAAAGAGAGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCT
TTGCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAGACCTCATGCAGCTACAAGAGCTTCACGAGTATGAGACGGAAC
TGGAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAGCAAAGAAGAAGCTGGAAGGGGACCTGAAAGACCTGGAGCTTCAGGCCGACT
CTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTGCAGGTCCATGAGCTGGAGAAGTCCAAGCGGGCCCTGGAGACCC
AGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGACGAGCTGCAAGCCACGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGC
AGGCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAGCAGAATGAGGAGAAGAGGAGGCAACTGCAGAGACAGGAAAAAC
ATCTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAGGCAGAAGCCAGGGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTT
GAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATGCTCAAAGCCGAAATGGAAGACCTGGTCAGCTCCAAGGATGAC

>37804_37804_7_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371554_MYH11_chr16_15815477_ENST00000452625_length(amino acids)=309AA_BP=36
MLPSSWLSSHSLWLWQRSHLWRHGHLPALFESPSSEPSRQATGQLLCQFLLLEVRLFASPLSGGEVLLCGFADPVAHGLHVALLLLQLLL
QLGDPGLQAALLVLECVPGLLLDLLLQLCNLGLQRRDGGLELGLDGPLHLVELAPELLVLPLELLPGTLILLGRAALCGQLVAELLGLLL
VLLGHLALVLHLQQDFLQLLVFLLQRLGGRLFLSELALECVHLAAHGLVALRGLIQLPLQLPAVGVDALGLLLCLLQLPLELLDPGIAFL

--------------------------------------------------------------
>37804_37804_8_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371554_MYH11_chr16_15815477_ENST00000576790_length(transcript)=2907nt_BP=1124nt
GTGCCCGGATGCTGGGGCGAGGGAGGGTGCACTGCGGCGCCCCCTCCTCGCGTGGTCCTGGCCGACGCATGTCCGGCAGTGACGAGTGTC
GGCCTGGTGGCTACGGCCACCATCTTTCTTGGGTTTGGTCCTGTTCTGTAATTTTGTGCTGTGAAAGGGTCGTGGTGGAGCTTTTGGCTT
AAGAATTCTTTGTCCGGATTTAATTGCTCCTCCGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGC
AGAAATTGCCCAACTCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGA
TGCCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCC
TCAGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGG
TACTAAAGCATTCATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGT
GGCAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGC
TGACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAA
AGAAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATG
AAGAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGA
AATACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCT
ACAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGGCGAGGAAACGAGACCTCTTTCGTTCCTTCTAGAAGGTCTGGAGGA
CGTAGAGTTATTGAAAATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTTCAATGGAACCAAGGCCAGTGAATAAGCA
ACTTTCTACAGTTTTGCACCACGGCAAGAAAACCAAAAACCAAAACAAACAAACAAAAAAAACCCAACAACAACCCAGAACAAAGCAAAA
CCCAGCAGACTGTACTTAGCATTGTCTAAATCCATTCTCAAATTCCAAATATCACAGACACCCCTCACACAAGGAATATAAAAACCACCA
CCCTCCAGCCTGGGCAACGTAAGGGCCCCCCCCACAGGAAACTTCGCAGTGATGCACCAGGCAGAGAAAGGCAATGCCAGGGTCAAGCAG
CTCAAGAGGCAGCTGGAGGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAACCGCAGGAAGCTGCAGCGGGAGCTGGATGAGGCCACG
GAGAGCAACGAGGCCATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGAGAGAAACAGGCGGCCACCAAGTCGCTGAAGCAGAAA
GACAAGAAGCTGAAGGAAATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTACAAGGAGCAGGCCGAGCAGCTCAGCAAC
GAGCTGGCCACAGAGCGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGGCAGAACAAGGAGCTCCGGAGCAAGCTC
CACGAGATGGAGGGGGCCGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTGGAGGCCAAGATTGCACAGCTGGAGGAGCAGGTCGAG
CAGGAGGCCAGGAACGCACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATCGCCCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGC
AACATGGAGGCCATGAGCGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCCGCCGCTGAGAGGGCTCGCAAACAAGCGGACCTCGAG
AAGGAGGAACTGGCAGAGGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGAAGGACTTTCAAAGAGAGCTGGAAGATGCCCGTGCCT
CCAGAGATGAGATCTTTGCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAGACCTCATGCAGCTACAAGAGCTTCACG
AGTATGAGACGGAACTGGAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAGCAAAGAAGAAGCTGGAAGGGGACCTGAAAGACCTGG
AGCTTCAGGCCGACTCTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTGCAGGTCCATGAGCTGGAGAAGTCCAAGC
GGGCCCTGGAGACCCAGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGACGAGCTGCAAGCCACGGAGGACGCCAAACTGCGGC
TGGAAGTCAACATGCAGGCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAGCAGAATGAGGAGAAGAGGAGGCAACTGC
AGAGACAGGAAAAACATCTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAGGCAGAAGCCAGGGAGAAGGAAACCAAGGCCCTGTCC
CTGGCTCGGGCCCTTGAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATGCTCAAAGCCGAAATGGAAGACCTGGTC

>37804_37804_8_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371554_MYH11_chr16_15815477_ENST00000576790_length(amino acids)=352AA_BP=
MHEVCFQALGFLLILFGCGKDLISGGTGIFQLSLKVLHLSLPDRLLASSSASSSFSRSACLRALSAAARSCCVALRTRSLMASMLPCSSS
SSSSSWAIRASRRRFSSWSAFLASCSTCSSSCAILASSAAMVDLNLDLTAPSISWSLLRSSLFCRSSCCRALSFFWAVLRSVASSLLSCS
ACSLYCSAILRSSSTCSKISFSFLSFCFSDLVAACFSLSLLLSAFTSRPMASLLSVASSSSRCSFLRLALMRWDSSSASSSCLLSCLTLA

--------------------------------------------------------------
>37804_37804_9_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371646_MYH11_chr16_15815477_ENST00000300036_length(transcript)=2559nt_BP=1019nt
GGCACGCAGTAGCTCTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTA
TAATCCTTTTCTTTTCAAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAGAAATTGCCCAACT
CATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATGCCTTGGACAAGAT
TCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCCTCAGGAACGTACCCT
GACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTACTAAAGCATTCAT
GGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGGCAGAGAAAGTGGT
TGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTGACCATGGTGAGCC
CATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAGAAGTAGTGAAGAA
GCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAAGAAAAACCCAAGA
TCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGG
AAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTACAAGAGCCTCACTA
ATGACTGGGAAGACCACTTGGCAGTCAAGGCGAGGAAACGAGACCTCTTTCGTTCCTTCTAGAAGGTCTGGAGGACGTAGAGTTATTGAA
AATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTTCAATGGAACCAAGGCCAGTGAATAAGCAGAGAAAGGCAATGCC
AGGGTCAAGCAGCTCAAGAGGCAGCTGGAGGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAACCGCAGGAAGCTGCAGCGGGAGCTG
GATGAGGCCACGGAGAGCAACGAGGCCATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGAGAGAAACAGGCGGCCACCAAGTCG
CTGAAGCAGAAAGACAAGAAGCTGAAGGAAATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTACAAGGAGCAGGCCGAG
CAGCTCAGCAACGAGCTGGCCACAGAGCGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGGCAGAACAAGGAGCTC
CGGAGCAAGCTCCACGAGATGGAGGGGGCCGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTGGAGGCCAAGATTGCACAGCTGGAG
GAGCAGGTCGAGCAGGAGGCCAGGAACGCACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATCGCCCAGCTGGAGGAGGAGCTGGAG
GAGGAGCAGGGCAACATGGAGGCCATGAGCGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCCGCCGCTGAGAGGGCTCGCAAACAA
GCGGACCTCGAGAAGGAGGAACTGGCAGAGGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGAAGGACTTTCAAAGAGAGCTGGAAG
ATGCCCGTGCCTCCAGAGATGAGATCTTTGCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAGACCTCATGCAGCTAC
AAGAGCTTCACGAGTATGAGACGGAACTGGAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAGCAAAGAAGAAGCTGGAAGGGGACC
TGAAAGACCTGGAGCTTCAGGCCGACTCTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTGCAGGTCCATGAGCTGG
AGAAGTCCAAGCGGGCCCTGGAGACCCAGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGACGAGCTGCAAGCCACGGAGGACG
CCAAACTGCGGCTGGAAGTCAACATGCAGGCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAGCAGAATGAGGAGAAGA
GGAGGCAACTGCAGAGACAGGAAAAACATCTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAGGCAGAAGCCAGGGAGAAGGAAACC
AAGGCCCTGTCCCTGGCTCGGGCCCTTGAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATGCTCAAAGCCGAAATG

>37804_37804_9_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371646_MYH11_chr16_15815477_ENST00000300036_length(amino acids)=356AA_BP=
MHEVCFQALGFLLILFGCGKDLISGGTGIFQLSLKVLHLSLPDRLLASSSASSSFSRSACLRALSAAARSCCVALRTRSLMASMLPCSSS
SSSSSWAIRASRRRFSSWSAFLASCSTCSSSCAILASSAAMVDLNLDLTAPSISWSLLRSSLFCRSSCCRALSFFWAVLRSVASSLLSCS
ACSLYCSAILRSSSTCSKISFSFLSFCFSDLVAACFSLSLLLSAFTSRPMASLLSVASSSSRCSFLRLALMRWDSSSASSSCLLSCLTLA

--------------------------------------------------------------
>37804_37804_10_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371646_MYH11_chr16_15815477_ENST00000396324_length(transcript)=3378nt_BP=1019nt
GGCACGCAGTAGCTCTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTA
TAATCCTTTTCTTTTCAAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAGAAATTGCCCAACT
CATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATGCCTTGGACAAGAT
TCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCCTCAGGAACGTACCCT
GACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTACTAAAGCATTCAT
GGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGGCAGAGAAAGTGGT
TGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTGACCATGGTGAGCC
CATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAGAAGTAGTGAAGAA
GCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAAGAAAAACCCAAGA
TCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGG
AAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTACAAGAGCCTCACTA
ATGACTGGGAAGACCACTTGGCAGTCAAGGCGAGGAAACGAGACCTCTTTCGTTCCTTCTAGAAGGTCTGGAGGACGTAGAGTTATTGAA
AATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTTCAATGGAACCAAGGCCAGTGAATAAGCAACTTTCTACAGTTTT
GCACCACGGCAAGAAAACCAAAAACCAAAACAAACAAACAAAAAAAACCCAACAACAACCCAGAACAAAGCAAAACCCAGCAGACTGTAC
TTAGCATTGTCTAAATCCATTCTCAAATTCCAAATATCACAGACACCCCTCACACAAGGAATATAAAAACCACCACCCTCCAGCCTGGGC
AACGTAGTAAAACCTCATCTATACAAGAATTTAAAAATAAGCTGGGCGTGGTGGTACACACCTGTGGTCCCAGCTACTAGGGAGGCTGAG
CCAGGAAGAACGCTCCAGCCCAGGACTTCGAGGCTGCAATGAGCTATAATTGCATCATTGCACTCCAGCCTGGGCAACAGAGACCCTGTC
TCAACCACCACCACCACCACCACCCCTACTACCCCTGTATTCAAGGTAAAAATTGAAGTTTGTATGATGTAAGAGATGAGAAAAACCCAA
CAGGAAACACAGACACATCCTCCAGTTCTATCAATGGATTGTGCAGACACTGAGTTTTTAGAAAAACATATCCACGGTAACCGGTCCCTG
GCAATTCTGTTTACATGAAATGGGGAGAAAGTCACCGAAATGGGTGCCGCCGGCCCCCACTCCCAATTCATTCCCTAACCTGCAAACCTT
TCCAACTTCTCACGTCAGGCCTTTGAGAATTCTTTCCCCCTCTCCTGGTTTCCACACCTCAGACACGCACAGTTCACCAAGTGCCTTCTG
TAGTCACATGAATTGAAAAGGAGACGCTGCTCCCACGGAGGGGAGCAGGAATGCTGCACTGTTTACACCCTGACTGTGCTTGCAGAGAAA
GGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTGGAGGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAACCGCAGGAAGCTGCAG
CGGGAGCTGGATGAGGCCACGGAGAGCAACGAGGCCATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGAGAGAAACAGGCGGCC
ACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAGGAAATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTACAAGGAG
CAGGCCGAGCAGCTCAGCAACGAGCTGGCCACAGAGCGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGGCAGAAC
AAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGGGCCGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTGGAGGCCAAGATTGCA
CAGCTGGAGGAGCAGGTCGAGCAGGAGGCCAGGAACGCACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATCGCCCAGCTGGAGGAG
GAGCTGGAGGAGGAGCAGGGCAACATGGAGGCCATGAGCGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCCGCCGCTGAGAGGGCT
CGCAAACAAGCGGACCTCGAGAAGGAGGAACTGGCAGAGGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGAAGGACTTTCAAAGAG
AGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCTTTGCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAGACCTCA
TGCAGCTACAAGAGCTTCACGAGTATGAGACGGAACTGGAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAGCAAAGAAGAAGCTGG
AAGGGGACCTGAAAGACCTGGAGCTTCAGGCCGACTCTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTGCAGGTCC
ATGAGCTGGAGAAGTCCAAGCGGGCCCTGGAGACCCAGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGACGAGCTGCAAGCCA
CGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGCAGGCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAGCAGAATG
AGGAGAAGAGGAGGCAACTGCAGAGACAGGAAAAACATCTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAGGCAGAAGCCAGGGAG
AAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTTGAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATGCTCAAA

>37804_37804_10_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371646_MYH11_chr16_15815477_ENST00000396324_length(amino acids)=296AA_BP=36
MLPSSWLSSHSLWLWQRSHLWRHGHLPALFESPSSEPSRQATGQLLCQFLLLEVRLFASPLSGGEVLLCGFADPVAHGLHVALLLLQLLL
QLGDPGLQAALLVLECVPGLLLDLLLQLCNLGLQRRDGGLELGLDGPLHLVELAPELLVLPLELLPGTLILLGRAALCGQLVAELLGLLL
VLLGHLALVLHLQQDFLQLLVFLLQRLGGRLFLSELALECVHLAAHGLVALRGLIQLPLQLPAVGVDALGLLLCLLQLPLELLDPGIAFL

--------------------------------------------------------------
>37804_37804_11_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371646_MYH11_chr16_15815477_ENST00000452625_length(transcript)=3417nt_BP=1019nt
GGCACGCAGTAGCTCTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTA
TAATCCTTTTCTTTTCAAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAGAAATTGCCCAACT
CATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATGCCTTGGACAAGAT
TCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCCTCAGGAACGTACCCT
GACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTACTAAAGCATTCAT
GGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGGCAGAGAAAGTGGT
TGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTGACCATGGTGAGCC
CATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAGAAGTAGTGAAGAA
GCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAAGAAAAACCCAAGA
TCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGG
AAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTACAAGAGCCTCACTA
ATGACTGGGAAGACCACTTGGCAGTCAAGGCGAGGAAACGAGACCTCTTTCGTTCCTTCTAGAAGGTCTGGAGGACGTAGAGTTATTGAA
AATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTTCAATGGAACCAAGGCCAGTGAATAAGCAACTTTCTACAGTTTT
GCACCACGGCAAGAAAACCAAAAACCAAAACAAACAAACAAAAAAAACCCAACAACAACCCAGAACAAAGCAAAACCCAGCAGACTGTAC
TTAGCATTGTCTAAATCCATTCTCAAATTCCAAATATCACAGACACCCCTCACACAAGGAATATAAAAACCACCACCCTCCAGCCTGGGC
AACGTAGTAAAACCTCATCTATACAAGAATTTAAAAATAAGCTGGGCGTGGTGGTACACACCTGTGGTCCCAGCTACTAGGGAGGCTGAG
CCAGGAAGAACGCTCCAGCCCAGGACTTCGAGGCTGCAATGAGCTATAATTGCATCATTGCACTCCAGCCTGGGCAACAGAGACCCTGTC
TCAACCACCACCACCACCACCACCCCTACTACCCCTGTATTCAAGGTAAAAATTGAAGTTTGTATGATGTAAGAGATGAGAAAAACCCAA
CAGGAAACACAGACACATCCTCCAGTTCTATCAATGGATTGTGCAGACACTGAGTTTTTAGAAAAACATATCCACGGTAACCGGTCCCTG
GCAATTCTGTTTACATGAAATGGGGAGAAAGTCACCGAAATGGGTGCCGCCGGCCCCCACTCCCAATTCATTCCCTAACCTGCAAACCTT
TCCAACTTCTCACGTCAGGCCTTTGAGAATTCTTTCCCCCTCTCCTGGTTTCCACACCTCAGACACGCACAGTTCACCAAGTGCCTTCTG
TAGTCACATGAATTGAAAAGGAGACGCTGCTCCCACGGAGGGGAGCAGGAATGCTGCACTGTTTACACCCTGACTGTGCTTAGGGCCCCC
CCCACAGGAAACTTCGCAGTGATGCACCAGGCAGAGAAAGGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTGGAGGAGGCAGAGGAG
GAGTCCCAGCGCATCAACGCCAACCGCAGGAAGCTGCAGCGGGAGCTGGATGAGGCCACGGAGAGCAACGAGGCCATGGGCCGCGAGGTG
AACGCACTCAAGAGCAAGCTCAGAGAGAAACAGGCGGCCACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAGGAAATCTTGCTGCAG
GTGGAGGACGAGCGCAAGATGGCCGAGCAGTACAAGGAGCAGGCCGAGCAGCTCAGCAACGAGCTGGCCACAGAGCGCAGCACGGCCCAG
AAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGGCAGAACAAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGGGCCGTCAAGTCCAAG
TTCAAGTCCACCATCGCGGCGCTGGAGGCCAAGATTGCACAGCTGGAGGAGCAGGTCGAGCAGGAGGCCAGGAACGCACTCCAGGACGAG
AAGCGCCGCCTGGAGGCCCGGATCGCCCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGCAACATGGAGGCCATGAGCGACCGGGTCCGC
AAAGCCACACAGCAGGACCTCGCCGCCGCTGAGAGGGCTCGCAAACAAGCGGACCTCGAGAAGGAGGAACTGGCAGAGGAGCTGGCCAGT
AGCCTGTCGGGAAGGCTCAGATGAAGGACTTTCAAAGAGAGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCTTTGCCACAGCCAAAG
AGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAGACCTCATGCAGCTACAAGAGCTTCACGAGTATGAGACGGAACTGGAAGACGAGCGAA
AGCAACGTGCCCTGGCAGCTGCAGCAAAGAAGAAGCTGGAAGGGGACCTGAAAGACCTGGAGCTTCAGGCCGACTCTGCCATCAAGGGGA
GGGAGGAAGCCATCAAGCAGCTACGCAAACTGCAGGTCCATGAGCTGGAGAAGTCCAAGCGGGCCCTGGAGACCCAGATGGAGGAGATGA
AGACGCAGCTGGAAGAGCTGGAGGACGAGCTGCAAGCCACGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGCAGGCGCTCAAGGGCC
AGTTCGAAAGGGATCTCCAAGCCCGGGACGAGCAGAATGAGGAGAAGAGGAGGCAACTGCAGAGACAGGAAAAACATCTCTTCCAAATAC
GCGGATGAGAGGGACAGAGCTGAGGCAGAAGCCAGGGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTTGAAGAGGCCTTGGAA

>37804_37804_11_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371646_MYH11_chr16_15815477_ENST00000452625_length(amino acids)=309AA_BP=36
MLPSSWLSSHSLWLWQRSHLWRHGHLPALFESPSSEPSRQATGQLLCQFLLLEVRLFASPLSGGEVLLCGFADPVAHGLHVALLLLQLLL
QLGDPGLQAALLVLECVPGLLLDLLLQLCNLGLQRRDGGLELGLDGPLHLVELAPELLVLPLELLPGTLILLGRAALCGQLVAELLGLLL
VLLGHLALVLHLQQDFLQLLVFLLQRLGGRLFLSELALECVHLAAHGLVALRGLIQLPLQLPAVGVDALGLLLCLLQLPLELLDPGIAFL

--------------------------------------------------------------
>37804_37804_12_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371646_MYH11_chr16_15815477_ENST00000576790_length(transcript)=2802nt_BP=1019nt
GGCACGCAGTAGCTCTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTA
TAATCCTTTTCTTTTCAAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAGAAATTGCCCAACT
CATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATGCCTTGGACAAGAT
TCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCCTCAGGAACGTACCCT
GACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTACTAAAGCATTCAT
GGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGGCAGAGAAAGTGGT
TGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTGACCATGGTGAGCC
CATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAGAAGTAGTGAAGAA
GCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAAGAAAAACCCAAGA
TCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGG
AAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTACAAGAGCCTCACTA
ATGACTGGGAAGACCACTTGGCAGTCAAGGCGAGGAAACGAGACCTCTTTCGTTCCTTCTAGAAGGTCTGGAGGACGTAGAGTTATTGAA
AATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTTCAATGGAACCAAGGCCAGTGAATAAGCAACTTTCTACAGTTTT
GCACCACGGCAAGAAAACCAAAAACCAAAACAAACAAACAAAAAAAACCCAACAACAACCCAGAACAAAGCAAAACCCAGCAGACTGTAC
TTAGCATTGTCTAAATCCATTCTCAAATTCCAAATATCACAGACACCCCTCACACAAGGAATATAAAAACCACCACCCTCCAGCCTGGGC
AACGTAAGGGCCCCCCCCACAGGAAACTTCGCAGTGATGCACCAGGCAGAGAAAGGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTG
GAGGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAACCGCAGGAAGCTGCAGCGGGAGCTGGATGAGGCCACGGAGAGCAACGAGGCC
ATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGAGAGAAACAGGCGGCCACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAG
GAAATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTACAAGGAGCAGGCCGAGCAGCTCAGCAACGAGCTGGCCACAGAG
CGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGGCAGAACAAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGG
GCCGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTGGAGGCCAAGATTGCACAGCTGGAGGAGCAGGTCGAGCAGGAGGCCAGGAAC
GCACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATCGCCCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGCAACATGGAGGCCATG
AGCGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCCGCCGCTGAGAGGGCTCGCAAACAAGCGGACCTCGAGAAGGAGGAACTGGCA
GAGGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGAAGGACTTTCAAAGAGAGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCT
TTGCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAGACCTCATGCAGCTACAAGAGCTTCACGAGTATGAGACGGAAC
TGGAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAGCAAAGAAGAAGCTGGAAGGGGACCTGAAAGACCTGGAGCTTCAGGCCGACT
CTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTGCAGGTCCATGAGCTGGAGAAGTCCAAGCGGGCCCTGGAGACCC
AGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGACGAGCTGCAAGCCACGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGC
AGGCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAGCAGAATGAGGAGAAGAGGAGGCAACTGCAGAGACAGGAAAAAC
ATCTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAGGCAGAAGCCAGGGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTT
GAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATGCTCAAAGCCGAAATGGAAGACCTGGTCAGCTCCAAGGATGAC

>37804_37804_12_HSP90AB1-MYH11_HSP90AB1_chr6_44218074_ENST00000371646_MYH11_chr16_15815477_ENST00000576790_length(amino acids)=352AA_BP=
MHEVCFQALGFLLILFGCGKDLISGGTGIFQLSLKVLHLSLPDRLLASSSASSSFSRSACLRALSAAARSCCVALRTRSLMASMLPCSSS
SSSSSWAIRASRRRFSSWSAFLASCSTCSSSCAILASSAAMVDLNLDLTAPSISWSLLRSSLFCRSSCCRALSFFWAVLRSVASSLLSCS
ACSLYCSAILRSSSTCSKISFSFLSFCFSDLVAACFSLSLLLSAFTSRPMASLLSVASSSSRCSFLRLALMRWDSSSASSSCLLSCLTLA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HSP90AB1-MYH11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000353801+112215_5520725.0AHSA1
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371554+112215_5520725.0AHSA1
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371646+112215_5520725.0AHSA1
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000353801+1122_2140725.0BIRC2
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371554+1122_2140725.0BIRC2
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371646+1122_2140725.0BIRC2
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000353801+112620_7230725.0NR1D1
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371554+112620_7230725.0NR1D1
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371646+112620_7230725.0NR1D1
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000353801+112264_6080725.0NR3C1
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000353801+1129_2310725.0NR3C1
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371554+112264_6080725.0NR3C1
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371554+1129_2310725.0NR3C1
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371646+112264_6080725.0NR3C1
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371646+1129_2310725.0NR3C1
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000353801+1122_5270725.0TP53
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371554+1122_5270725.0TP53
HgeneHSP90AB1chr6:44218074chr16:15815477ENST00000371646+1122_5270725.0TP53


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSP90AB1-MYH11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HSP90AB1-MYH11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource