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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HSP90B1-ACTN4 (FusionGDB2 ID:37815)

Fusion Gene Summary for HSP90B1-ACTN4

Fusion gene summary

Fusion gene information	Fusion gene name: HSP90B1-ACTN4
	Fusion gene ID: 37815
		Hgene	Tgene
	Gene symbol	HSP90B1	ACTN4
	Gene ID	7184	81
	Gene name	heat shock protein 90 beta family member 1	actinin alpha 4
	Synonyms	ECGP\|GP96\|GRP94\|HEL-S-125m\|HEL35\|TRA1	ACTININ-4\|FSGS\|FSGS1
	Cytomap	12q23.3	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	endoplasmin94 kDa glucose-regulated proteinendothelial cell (HBMEC) glycoproteinepididymis luminal protein 35epididymis secretory sperm binding protein Li 125mheat shock protein 90 kDa beta member 1heat shock protein 90kDa beta (Grp94), member 1hea	alpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4
	Modification date	20200320	20200327
	UniProtAcc	P14625	O43707
	Ensembl transtripts involved in fusion gene	ENST00000299767,	ENST00000497637, ENST00000252699, ENST00000390009, ENST00000424234,
Fusion gene scores	* DoF score	19 X 19 X 10=3610	27 X 38 X 12=12312
	# samples	25	48
	** MAII score	log2(25/3610*10)=-3.85199883711245 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(48/12312*10)=-4.68088692071969 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HSP90B1 [Title/Abstract] AND ACTN4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HSP90B1(104331584)-ACTN4(39219913), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HSP90B1	GO:0001666	response to hypoxia	15620698
Hgene	HSP90B1	GO:0031247	actin rod assembly	19000834
Hgene	HSP90B1	GO:0043666	regulation of phosphoprotein phosphatase activity	19000834
Hgene	HSP90B1	GO:0071318	cellular response to ATP	19000834
Tgene	ACTN4	GO:0033209	tumor necrosis factor-mediated signaling pathway	25411248
Tgene	ACTN4	GO:0035357	peroxisome proliferator activated receptor signaling pathway	22351778
Tgene	ACTN4	GO:0048384	retinoic acid receptor signaling pathway	22351778
Tgene	ACTN4	GO:0051272	positive regulation of cellular component movement	9508771

Fusion gene breakpoints across HSP90B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACTN4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4H2	HSP90B1	chr12	104331584	+	ACTN4	chr19	39219913	+

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Fusion Gene ORF analysis for HSP90B1-ACTN4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000299767	ENST00000497637	HSP90B1	chr12	104331584	+	ACTN4	chr19	39219913	+
In-frame	ENST00000299767	ENST00000252699	HSP90B1	chr12	104331584	+	ACTN4	chr19	39219913	+
In-frame	ENST00000299767	ENST00000390009	HSP90B1	chr12	104331584	+	ACTN4	chr19	39219913	+
In-frame	ENST00000299767	ENST00000424234	HSP90B1	chr12	104331584	+	ACTN4	chr19	39219913	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000299767

HSP90B1

chr12

104331584

ENST00000252699

ACTN4

chr19

39219913

3347

1037

182

1195

337

ENST00000299767

HSP90B1

chr12

104331584

ENST00000424234

ACTN4

chr19

39219913

1196

1037

182

1195

338

ENST00000299767

HSP90B1

chr12

104331584

ENST00000390009

ACTN4

chr19

39219913

1211

1037

182

1195

337

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000299767	ENST00000252699	HSP90B1	chr12	104331584	+	ACTN4	chr19	39219913	+	0.000689608	0.9993104
ENST00000299767	ENST00000424234	HSP90B1	chr12	104331584	+	ACTN4	chr19	39219913	+	0.000457901	0.9995421
ENST00000299767	ENST00000390009	HSP90B1	chr12	104331584	+	ACTN4	chr19	39219913	+	0.000502168	0.9994978

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Fusion Genomic Features for HSP90B1-ACTN4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HSP90B1	chr12	104331584	+	ACTN4	chr19	39219913	+	0.9923264	0.007673619
HSP90B1	chr12	104331584	+	ACTN4	chr19	39219913	+	0.9923264	0.007673619

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HSP90B1-ACTN4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:104331584/chr19:39219913)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HSP90B1 P14625	ACTN4 O43707
FUNCTION: Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000250\|UniProtKB:P08113, ECO:0000269\|PubMed:18264092, ECO:0000269\|PubMed:32272059}.	FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). {ECO:0000250\|UniProtKB:P57780, ECO:0000269\|PubMed:15772161, ECO:0000269\|PubMed:22351778, ECO:0000305\|PubMed:9508771}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

778_789

640

693.0

Calcium binding

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

819_830

640

693.0

Calcium binding

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

765_800

640

693.0

Domain

EF-hand 1

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

806_841

640

693.0

Domain

EF-hand 2

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

649_752

640

693.0

Repeat

Spectrin 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HSP90B1

chr12:104331584

chr19:39219913

ENST00000299767

800_803

285

804.0

Motif

Note=Prevents secretion from ER

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

778_789

859

912.0

Calcium binding

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

819_830

859

912.0

Calcium binding

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

19_26

859

912.0

Compositional bias

Poly-Gly

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

19_26

640

693.0

Compositional bias

Poly-Gly

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

163_269

859

912.0

Domain

Calponin-homology (CH) 2

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

50_154

859

912.0

Domain

Calponin-homology (CH) 1

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

765_800

859

912.0

Domain

EF-hand 1

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

806_841

859

912.0

Domain

EF-hand 2

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

163_269

640

693.0

Domain

Calponin-homology (CH) 2

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

50_154

640

693.0

Domain

Calponin-homology (CH) 1

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

84_88

859

912.0

Motif

LXXLL motif

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

84_88

640

693.0

Motif

LXXLL motif

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

177_192

859

912.0

Region

Polyphosphoinositide (PIP2)-binding

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

1_269

859

912.0

Region

Note=Actin-binding

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

177_192

640

693.0

Region

Polyphosphoinositide (PIP2)-binding

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

1_269

640

693.0

Region

Note=Actin-binding

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

293_403

859

912.0

Repeat

Spectrin 1

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

413_518

859

912.0

Repeat

Spectrin 2

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

528_639

859

912.0

Repeat

Spectrin 3

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000252699

649_752

859

912.0

Repeat

Spectrin 4

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

293_403

640

693.0

Repeat

Spectrin 1

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

413_518

640

693.0

Repeat

Spectrin 2

Tgene

ACTN4

chr12:104331584

chr19:39219913

ENST00000390009

528_639

640

693.0

Repeat

Spectrin 3

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Fusion Gene Sequence for HSP90B1-ACTN4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>37815_37815_1_HSP90B1-ACTN4_HSP90B1_chr12_104331584_ENST00000299767_ACTN4_chr19_39219913_ENST00000252699_length(transcript)=3347nt_BP=1037nt
GATTGGTGGGTTCATGTTTCCCGTCCCCCGCCCGCGGGAAGTGGGGGTGAAAAGCGGCCCGACCTGCTTGCGGTGTAGTGGGCGGACCGC
GCGGCTGGAGGTGTGAGGATCCGAACCCAGGGGTGGGGGGTGGAGGCGGCTCCTGCGATCGAAGGGGACTTGAGACTCACCGGCCGCACG
CCATGAGGGCCCTGTGGGTGCTGGGCCTCTGCTGCGTCCTGCTGACCTTCGGGTCGGTCAGAGCTGACGATGAAGTTGATGTGGATGGTA
CAGTAGAAGAGGATCTGGGTAAAAGTAGAGAAGGATCAAGGACGGATGATGAAGTAGTACAGAGAGAGGAAGAAGCTATTCAGTTGGATG
GATTAAATGCATCACAAATAAGAGAACTTAGAGAGAAGTCGGAAAAGTTTGCCTTCCAAGCCGAAGTTAACAGAATGATGAAACTTATCA
TCAATTCATTGTATAAAAATAAAGAGATTTTCCTGAGAGAACTGATTTCAAATGCTTCTGATGCTTTAGATAAGATAAGGCTAATATCAC
TGACTGATGAAAATGCTCTTTCTGGAAATGAGGAACTAACAGTCAAAATTAAGTGTGATAAGGAGAAGAACCTGCTGCATGTCACAGACA
CCGGTGTAGGAATGACCAGAGAAGAGTTGGTTAAAAACCTTGGTACCATAGCCAAATCTGGGACAAGCGAGTTTTTAAACAAAATGACTG
AAGCACAGGAAGATGGCCAGTCAACTTCTGAATTGATTGGCCAGTTTGGTGTCGGTTTCTATTCCGCCTTCCTTGTAGCAGATAAGGTTA
TTGTCACTTCAAAACACAACAACGATACCCAGCACATCTGGGAGTCTGACTCCAATGAATTTTCTGTAATTGCTGACCCAAGAGGAAACA
CTCTAGGACGGGGAACGACAATTACCCTTGTCTTAAAAGAAGAAGCATCTGATTACCTTGAATTGGATACAATTAAAAATCTCGTCAAAA
AATATTCACAGTTCATAAACTTTCCTATTTATGTATGGAGCAGCAAGAACTTCATCACAGCTGAGGAGCTGCGGAGAGAGCTGCCCCCCG
ACCAGGCCGAGTACTGCATCGCCCGCATGGCGCCATACCAGGGCCCTGACGCCGTGCCCGGTGCCCTCGACTACAAGTCCTTCTCCACGG
CCTTGTATGGCGAGAGCGACCTGTGAGGCCCCAGAGACCTGACCCAACACCCCCGACGGCCTCCAGGAGGGGCCTGGGCAGCCCCACAGT
CCCATTCCTCCACTCTGTATCTATGCAAAGCACTCTCTGCAGTCCTCCGGGGTGGGTGGGTGGGCAGGGAGGGGCTGGGGCAGGCTCTCT
CCTCTCTCTCTTTGTGGGTTGGCCAGGAGGTTCCCCCGACCAGGTTGGGGAGACTTGGGGCCAGCGCTTCTGGTCTGGTAAATATGTATG
ATGTGTTGTGCTTTTTTAACCAAGGAGGGGCCAGTGGATTCCCACAGCACAACCGGTCCCTTCCATGCCCTGGGATGCCTCACCACACCC
AGGTCTCTTCCTTTGCTCTGAGGTCCCTTCAAGGCCTCCCCAATCCAGGCCAAAGCCCCATGTGCCTTGTCCAGGAACTGCCTGGGCCAT
GCGAGGGGCCAGCAGAGGGCGCCACCACCACCTGACGGCTGGGGACCCACCCAGCCCCTCTCCCCTCTCTGCTCCAGACTCACTTGCCAT
TGCCAGGAGATGGCCCCAACAAGCACCCCGCTTTTGCAGCAGAGGAGCTGAGTTGGCAGACCGGGCCCCCCTGAACCGCACCCCATCCCA
CCAGCCCCGGCCTTGCTTTGTCTGGCCTCACGTGTCTCAGATTTTCTAAGAACCAAAAAAAAAAAAGGAAAAAAAACACAAAACAACAAA
AACCAAAAAAAAAAAAAATCACAAAAACAAAAAAACTATAAAAAAGAAAGAATTAAAAACTTTCAGAGAATTACTATTTACTTTATTAAC
TTACGGATTTATTATATAAATATATATTCACCTAGCAACATATCTCTGCCGTCTCTCCTGCTCTCATAATGAAGACATAGCCGATTCTCT
GCCCGGGCCCCTTGCTGATGCTCCTCCGGGTCTGCGTCGGGCGTGGGTCTCTGGGGACCCTCCAGAGGTGGAGGTGGGCTGATGGCCTGG
CTGCCTGGTGGTTGATGGTTTTGCTCCCCCTACCTTTTTTTTTTGAGTTTATTCTGATTGATTTTTTTTCTTGGTTTCTGGATAAACCAC
CCTCTGGGGACAGGATAATAAAACATGTAATATTTTTAAGAAGGATTCCTGCAGCATCATCTTTTTTTATTTCTCCTGTGTCTGTCCTCC
ACCTTCTAGGAGAGCCAGGGCAGAGCTAGCACTGTCTTAAGCTGTCAACGTGGACTAGCTCGTGTCATCTGCTCGAGAAGGGCTGTCGCT
GTTCTTGTTTCTGAGTGAGGAGTACGCAGGCCAGAGTGGTCACCCGGCCGTGAGCAGTGAGGGCCAGAGACTAGCCCCAGACAGGTGGAT
GCCAGAGAGAGTGGCACCCATGCCAGGCAAGGCCTAGGGAGGTGGTCTTGCTCAGCAACCCTGCCCTGAGCAGCAGGTGCGCCCATCCGG
AGATCCTAGGAGAAGGTGGCCACCTCCATCCACTAAGGAAGAGAAGGAAGACAGTGGCTTGAGGCAGGGAGCTCGCAGGACAGAGCCTGA
GCCACCCTGTCCCTCCCACCTGGCTCACCTGTCTGTGGGTCAGGCAGATGACCCCCTCACCCCCATCCAGGTGCTGGCTGCAGTGGCCTG
TGCAGAGAGGGGCAGGGTGAGTGCCCACCAGTCCCCGTACCCCTTCCCCCCATGCCCCACCATGCCGGGGTGGTACTCACAGAAGATGCA
GGTGAGGTGGGCCACACAGGACACGAACCGCTCGAAGTCCACACGCAGACGGCTATCCCGGTAGCGGCTGGTGAGGGTCTGGGTCAGCTG
GTTGTTCAGGTGGAAGCCTAGGGGGAGGCTGCTTCTGAGCCCAGTGGCCCACAGGGAACCCACCTTGGCATTGCATCCCCACCCCACCTC
CTCAGGGAGGACATGAATGCCACAGGGTGTCACACCCCAACTCTGCCCCATCCCGGCAGGGTGAGTACAGGCTGATCCCTTCAATCCTCT
GGGCCTGTTTCCTCATCCATCAAACGGACTAAGACAGCCCCGACCCCATAGGGTGTGTGAAGACAGAACGCTCAGGACAGCGTCTGACAC
GTGACTCGATGTGTGGGTACTGTTACTCCTTAAATCCTGTGGGGCTTTCTCCTTGCCAGTGGGCACTGGAGGATATTTCTGTGCAGCAAA

>37815_37815_1_HSP90B1-ACTN4_HSP90B1_chr12_104331584_ENST00000299767_ACTN4_chr19_39219913_ENST00000252699_length(amino acids)=337AA_BP=285
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLII
NSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKK

--------------------------------------------------------------
>37815_37815_2_HSP90B1-ACTN4_HSP90B1_chr12_104331584_ENST00000299767_ACTN4_chr19_39219913_ENST00000390009_length(transcript)=1211nt_BP=1037nt
GATTGGTGGGTTCATGTTTCCCGTCCCCCGCCCGCGGGAAGTGGGGGTGAAAAGCGGCCCGACCTGCTTGCGGTGTAGTGGGCGGACCGC
GCGGCTGGAGGTGTGAGGATCCGAACCCAGGGGTGGGGGGTGGAGGCGGCTCCTGCGATCGAAGGGGACTTGAGACTCACCGGCCGCACG
CCATGAGGGCCCTGTGGGTGCTGGGCCTCTGCTGCGTCCTGCTGACCTTCGGGTCGGTCAGAGCTGACGATGAAGTTGATGTGGATGGTA
CAGTAGAAGAGGATCTGGGTAAAAGTAGAGAAGGATCAAGGACGGATGATGAAGTAGTACAGAGAGAGGAAGAAGCTATTCAGTTGGATG
GATTAAATGCATCACAAATAAGAGAACTTAGAGAGAAGTCGGAAAAGTTTGCCTTCCAAGCCGAAGTTAACAGAATGATGAAACTTATCA
TCAATTCATTGTATAAAAATAAAGAGATTTTCCTGAGAGAACTGATTTCAAATGCTTCTGATGCTTTAGATAAGATAAGGCTAATATCAC
TGACTGATGAAAATGCTCTTTCTGGAAATGAGGAACTAACAGTCAAAATTAAGTGTGATAAGGAGAAGAACCTGCTGCATGTCACAGACA
CCGGTGTAGGAATGACCAGAGAAGAGTTGGTTAAAAACCTTGGTACCATAGCCAAATCTGGGACAAGCGAGTTTTTAAACAAAATGACTG
AAGCACAGGAAGATGGCCAGTCAACTTCTGAATTGATTGGCCAGTTTGGTGTCGGTTTCTATTCCGCCTTCCTTGTAGCAGATAAGGTTA
TTGTCACTTCAAAACACAACAACGATACCCAGCACATCTGGGAGTCTGACTCCAATGAATTTTCTGTAATTGCTGACCCAAGAGGAAACA
CTCTAGGACGGGGAACGACAATTACCCTTGTCTTAAAAGAAGAAGCATCTGATTACCTTGAATTGGATACAATTAAAAATCTCGTCAAAA
AATATTCACAGTTCATAAACTTTCCTATTTATGTATGGAGCAGCAAGAACTTCATCACAGCTGAGGAGCTGCGGAGAGAGCTGCCCCCCG
ACCAGGCCGAGTACTGCATCGCCCGCATGGCGCCATACCAGGGCCCTGACGCCGTGCCCGGTGCCCTCGACTACAAGTCCTTCTCCACGG

>37815_37815_2_HSP90B1-ACTN4_HSP90B1_chr12_104331584_ENST00000299767_ACTN4_chr19_39219913_ENST00000390009_length(amino acids)=337AA_BP=285
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLII
NSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKK

--------------------------------------------------------------
>37815_37815_3_HSP90B1-ACTN4_HSP90B1_chr12_104331584_ENST00000299767_ACTN4_chr19_39219913_ENST00000424234_length(transcript)=1196nt_BP=1037nt
GATTGGTGGGTTCATGTTTCCCGTCCCCCGCCCGCGGGAAGTGGGGGTGAAAAGCGGCCCGACCTGCTTGCGGTGTAGTGGGCGGACCGC
GCGGCTGGAGGTGTGAGGATCCGAACCCAGGGGTGGGGGGTGGAGGCGGCTCCTGCGATCGAAGGGGACTTGAGACTCACCGGCCGCACG
CCATGAGGGCCCTGTGGGTGCTGGGCCTCTGCTGCGTCCTGCTGACCTTCGGGTCGGTCAGAGCTGACGATGAAGTTGATGTGGATGGTA
CAGTAGAAGAGGATCTGGGTAAAAGTAGAGAAGGATCAAGGACGGATGATGAAGTAGTACAGAGAGAGGAAGAAGCTATTCAGTTGGATG
GATTAAATGCATCACAAATAAGAGAACTTAGAGAGAAGTCGGAAAAGTTTGCCTTCCAAGCCGAAGTTAACAGAATGATGAAACTTATCA
TCAATTCATTGTATAAAAATAAAGAGATTTTCCTGAGAGAACTGATTTCAAATGCTTCTGATGCTTTAGATAAGATAAGGCTAATATCAC
TGACTGATGAAAATGCTCTTTCTGGAAATGAGGAACTAACAGTCAAAATTAAGTGTGATAAGGAGAAGAACCTGCTGCATGTCACAGACA
CCGGTGTAGGAATGACCAGAGAAGAGTTGGTTAAAAACCTTGGTACCATAGCCAAATCTGGGACAAGCGAGTTTTTAAACAAAATGACTG
AAGCACAGGAAGATGGCCAGTCAACTTCTGAATTGATTGGCCAGTTTGGTGTCGGTTTCTATTCCGCCTTCCTTGTAGCAGATAAGGTTA
TTGTCACTTCAAAACACAACAACGATACCCAGCACATCTGGGAGTCTGACTCCAATGAATTTTCTGTAATTGCTGACCCAAGAGGAAACA
CTCTAGGACGGGGAACGACAATTACCCTTGTCTTAAAAGAAGAAGCATCTGATTACCTTGAATTGGATACAATTAAAAATCTCGTCAAAA
AATATTCACAGTTCATAAACTTTCCTATTTATGTATGGAGCAGCAAGAACTTCATCACAGCTGAGGAGCTGCGGAGAGAGCTGCCCCCCG
ACCAGGCCGAGTACTGCATCGCCCGCATGGCGCCATACCAGGGCCCTGACGCCGTGCCCGGTGCCCTCGACTACAAGTCCTTCTCCACGG

>37815_37815_3_HSP90B1-ACTN4_HSP90B1_chr12_104331584_ENST00000299767_ACTN4_chr19_39219913_ENST00000424234_length(amino acids)=338AA_BP=285
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLII
NSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKK

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Fusion Gene PPI Analysis for HSP90B1-ACTN4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	ACTN4	chr12:104331584	chr19:39219913	ENST00000252699		19	21	108_126	859.0	912.0	VCL
Tgene	ACTN4	chr12:104331584	chr19:39219913	ENST00000252699		19	21	12_26	859.0	912.0	VCL
Tgene	ACTN4	chr12:104331584	chr19:39219913	ENST00000252699		19	21	40_61	859.0	912.0	VCL
Tgene	ACTN4	chr12:104331584	chr19:39219913	ENST00000390009		12	14	108_126	640.0	693.0	VCL
Tgene	ACTN4	chr12:104331584	chr19:39219913	ENST00000390009		12	14	12_26	640.0	693.0	VCL
Tgene	ACTN4	chr12:104331584	chr19:39219913	ENST00000390009		12	14	40_61	640.0	693.0	VCL

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HSP90B1-ACTN4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HSP90B1-ACTN4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source