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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HSPA1A-TIAM2 (FusionGDB2 ID:37858)

Fusion Gene Summary for HSPA1A-TIAM2

check button Fusion gene summary
Fusion gene informationFusion gene name: HSPA1A-TIAM2
Fusion gene ID: 37858
HgeneTgene
Gene symbol

HSPA1A

TIAM2

Gene ID

3303

26230

Gene nameheat shock protein family A (Hsp70) member 1ATIAM Rac1 associated GEF 2
SynonymsHEL-S-103|HSP70-1|HSP70-1A|HSP70-2|HSP70.1|HSP70.2|HSP70I|HSP72|HSPA1STEF|TIAM-2
Cytomap

6p21.33

6q25.2-q25.3

Type of geneprotein-codingprotein-coding
Descriptionheat shock 70 kDa protein 1AHSP70-1/HSP70-2HSP70.1/HSP70.2Heat shock 70 kDa protein 1BHeat shock 70 kDa protein 2dnaK-type molecular chaperone HSP70-1epididymis secretory protein Li 103epididymis secretory sperm binding proteinheat shock 70 kDa prT-lymphoma invasion and metastasis-inducing protein 2SIF and TIAM1-like exchange factorT cell lymphoma invasion and metastasis 2
Modification date2020032720200313
UniProtAcc

P0DMV8

.
Ensembl transtripts involved in fusion geneENST00000375651, ENST00000608703, 
ENST00000383389, ENST00000400040, 
ENST00000422919, ENST00000430065, 
ENST00000433487, ENST00000441618, 
ENST00000449876, ENST00000452298, 
ENST00000458062, 		ENST00000275246, 
ENST00000318981, ENST00000360366, 
ENST00000367174, ENST00000449545, 
ENST00000456144, ENST00000456877, 
ENST00000461783, ENST00000528391, 
ENST00000529824, 
Fusion gene scores* DoF score7 X 8 X 2=11218 X 17 X 10=3060
# samples 723
** MAII scorelog2(7/112*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3060*10)=-3.73382588663564
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSPA1A [Title/Abstract] AND TIAM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSPA1A(31785719)-TIAM2(155160776), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSPA1A

GO:0006402

mRNA catabolic process

10205060

HgeneHSPA1A

GO:0006986

response to unfolded protein

10859165

HgeneHSPA1A

GO:0031396

regulation of protein ubiquitination

16809764

HgeneHSPA1A

GO:0031397

negative regulation of protein ubiquitination

12150907

HgeneHSPA1A

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

24613385

HgeneHSPA1A

GO:0033120

positive regulation of RNA splicing

20625543

HgeneHSPA1A

GO:0034605

cellular response to heat

24061851

HgeneHSPA1A

GO:0042026

protein refolding

15603737|21231916

HgeneHSPA1A

GO:0046034

ATP metabolic process

23921388

HgeneHSPA1A

GO:0050821

protein stabilization

21909508

HgeneHSPA1A

GO:0051131

chaperone-mediated protein complex assembly

10811660

HgeneHSPA1A

GO:0090084

negative regulation of inclusion body assembly

15603737|21231916

HgeneHSPA1A

GO:0097201

negative regulation of transcription from RNA polymerase II promoter in response to stress

9499401

HgeneHSPA1A

GO:1901029

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

20625543

HgeneHSPA1A

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

12150907|20625543

HgeneHSPA1A

GO:1902380

positive regulation of endoribonuclease activity

20625543


check buttonFusion gene breakpoints across HSPA1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TIAM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF339121HSPA1Achr6

31785719

+TIAM2chr6

155160776

-


Top

Fusion Gene ORF analysis for HSPA1A-TIAM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000375651ENST00000275246HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000375651ENST00000318981HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000375651ENST00000360366HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000375651ENST00000367174HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000375651ENST00000449545HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000375651ENST00000456144HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000375651ENST00000456877HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000375651ENST00000461783HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000375651ENST00000528391HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000375651ENST00000529824HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000608703ENST00000275246HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000608703ENST00000318981HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000608703ENST00000360366HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000608703ENST00000367174HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000608703ENST00000449545HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000608703ENST00000456144HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000608703ENST00000456877HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000608703ENST00000461783HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000608703ENST00000528391HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
5CDS-intronENST00000608703ENST00000529824HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000383389ENST00000275246HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000383389ENST00000318981HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000383389ENST00000360366HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000383389ENST00000367174HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000383389ENST00000449545HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000383389ENST00000456144HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000383389ENST00000456877HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000383389ENST00000461783HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000383389ENST00000528391HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000383389ENST00000529824HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000400040ENST00000275246HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000400040ENST00000318981HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000400040ENST00000360366HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000400040ENST00000367174HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000400040ENST00000449545HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000400040ENST00000456144HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000400040ENST00000456877HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000400040ENST00000461783HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000400040ENST00000528391HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000400040ENST00000529824HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000422919ENST00000275246HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000422919ENST00000318981HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000422919ENST00000360366HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000422919ENST00000367174HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000422919ENST00000449545HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000422919ENST00000456144HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000422919ENST00000456877HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000422919ENST00000461783HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000422919ENST00000528391HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000422919ENST00000529824HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000430065ENST00000275246HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000430065ENST00000318981HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000430065ENST00000360366HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000430065ENST00000367174HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000430065ENST00000449545HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000430065ENST00000456144HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000430065ENST00000456877HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000430065ENST00000461783HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000430065ENST00000528391HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000430065ENST00000529824HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000433487ENST00000275246HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000433487ENST00000318981HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000433487ENST00000360366HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000433487ENST00000367174HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000433487ENST00000449545HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000433487ENST00000456144HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000433487ENST00000456877HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000433487ENST00000461783HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000433487ENST00000528391HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000433487ENST00000529824HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000441618ENST00000275246HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000441618ENST00000318981HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000441618ENST00000360366HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000441618ENST00000367174HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000441618ENST00000449545HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000441618ENST00000456144HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000441618ENST00000456877HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000441618ENST00000461783HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000441618ENST00000528391HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000441618ENST00000529824HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000449876ENST00000275246HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000449876ENST00000318981HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000449876ENST00000360366HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000449876ENST00000367174HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000449876ENST00000449545HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000449876ENST00000456144HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000449876ENST00000456877HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000449876ENST00000461783HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000449876ENST00000528391HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000449876ENST00000529824HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000452298ENST00000275246HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000452298ENST00000318981HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000452298ENST00000360366HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000452298ENST00000367174HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000452298ENST00000449545HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000452298ENST00000456144HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000452298ENST00000456877HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000452298ENST00000461783HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000452298ENST00000528391HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000452298ENST00000529824HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000458062ENST00000275246HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000458062ENST00000318981HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000458062ENST00000360366HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000458062ENST00000367174HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000458062ENST00000449545HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000458062ENST00000456144HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000458062ENST00000456877HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000458062ENST00000461783HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000458062ENST00000528391HSPA1Achr6

31785719

+TIAM2chr6

155160776

-
intron-intronENST00000458062ENST00000529824HSPA1Achr6

31785719

+TIAM2chr6

155160776

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for HSPA1A-TIAM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for HSPA1A-TIAM2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31785719/:155160776)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSPA1A

P0DMV8

.
FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HSPA1A-TIAM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HSPA1A-TIAM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSPA1A-TIAM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HSPA1A-TIAM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource