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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HSPB11-NDC1 (FusionGDB2 ID:37921)

Fusion Gene Summary for HSPB11-NDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: HSPB11-NDC1
Fusion gene ID: 37921
HgeneTgene
Gene symbol

HSPB11

NDC1

Gene ID

51668

55706

Gene nameheat shock protein family B (small) member 11NDC1 transmembrane nucleoporin
SynonymsC1orf41|FAP232|HSPCO34|IFT25|PP25NET3|TMEM48
Cytomap

1p32.3

1p32.3

Type of geneprotein-codingprotein-coding
Descriptionintraflagellar transport protein 25 homologheat shock protein beta-11heat shock protein family B (small), member 11intraflagellar transport 25 homologplacental protein 25nucleoporin NDC1nuclear division cycle 1 homologtransmembrane protein 48
Modification date2020031320200313
UniProtAcc

Q9Y547

Q9BTX1

Ensembl transtripts involved in fusion geneENST00000194214, ENST00000371378, 
ENST00000489675, ENST00000371376, 
ENST00000371377, 		ENST00000234725, 
ENST00000537333, ENST00000540001, 
ENST00000480952, ENST00000371429, 
Fusion gene scores* DoF score7 X 7 X 4=1968 X 6 X 7=336
# samples 89
** MAII scorelog2(8/196*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSPB11 [Title/Abstract] AND NDC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNDC1(54252831)-HSPB11(54395818), # samples:1
HSPB11(54389577)-NDC1(54238162), # samples:2
Anticipated loss of major functional domain due to fusion event.NDC1-HSPB11 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HSPB11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NDC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-6441-01AHSPB11chr1

54389577

-NDC1chr1

54238162

-
ChimerDB4HNSCTCGA-CV-6441HSPB11chr1

54389577

-NDC1chr1

54238162

-


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Fusion Gene ORF analysis for HSPB11-NDC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000194214ENST00000234725HSPB11chr1

54389577

-NDC1chr1

54238162

-
5CDS-3UTRENST00000194214ENST00000537333HSPB11chr1

54389577

-NDC1chr1

54238162

-
5CDS-3UTRENST00000194214ENST00000540001HSPB11chr1

54389577

-NDC1chr1

54238162

-
5CDS-3UTRENST00000371378ENST00000234725HSPB11chr1

54389577

-NDC1chr1

54238162

-
5CDS-3UTRENST00000371378ENST00000537333HSPB11chr1

54389577

-NDC1chr1

54238162

-
5CDS-3UTRENST00000371378ENST00000540001HSPB11chr1

54389577

-NDC1chr1

54238162

-
5CDS-intronENST00000194214ENST00000480952HSPB11chr1

54389577

-NDC1chr1

54238162

-
5CDS-intronENST00000371378ENST00000480952HSPB11chr1

54389577

-NDC1chr1

54238162

-
5UTR-3CDSENST00000489675ENST00000371429HSPB11chr1

54389577

-NDC1chr1

54238162

-
5UTR-3UTRENST00000489675ENST00000234725HSPB11chr1

54389577

-NDC1chr1

54238162

-
5UTR-3UTRENST00000489675ENST00000537333HSPB11chr1

54389577

-NDC1chr1

54238162

-
5UTR-3UTRENST00000489675ENST00000540001HSPB11chr1

54389577

-NDC1chr1

54238162

-
5UTR-intronENST00000489675ENST00000480952HSPB11chr1

54389577

-NDC1chr1

54238162

-
In-frameENST00000194214ENST00000371429HSPB11chr1

54389577

-NDC1chr1

54238162

-
In-frameENST00000371378ENST00000371429HSPB11chr1

54389577

-NDC1chr1

54238162

-
intron-3CDSENST00000371376ENST00000371429HSPB11chr1

54389577

-NDC1chr1

54238162

-
intron-3CDSENST00000371377ENST00000371429HSPB11chr1

54389577

-NDC1chr1

54238162

-
intron-3UTRENST00000371376ENST00000234725HSPB11chr1

54389577

-NDC1chr1

54238162

-
intron-3UTRENST00000371376ENST00000537333HSPB11chr1

54389577

-NDC1chr1

54238162

-
intron-3UTRENST00000371376ENST00000540001HSPB11chr1

54389577

-NDC1chr1

54238162

-
intron-3UTRENST00000371377ENST00000234725HSPB11chr1

54389577

-NDC1chr1

54238162

-
intron-3UTRENST00000371377ENST00000537333HSPB11chr1

54389577

-NDC1chr1

54238162

-
intron-3UTRENST00000371377ENST00000540001HSPB11chr1

54389577

-NDC1chr1

54238162

-
intron-intronENST00000371376ENST00000480952HSPB11chr1

54389577

-NDC1chr1

54238162

-
intron-intronENST00000371377ENST00000480952HSPB11chr1

54389577

-NDC1chr1

54238162

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371378HSPB11chr154389577-ENST00000371429NDC1chr154238162-308635133575180
ENST00000194214HSPB11chr154389577-ENST00000371429NDC1chr154238162-3443708390932180

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371378ENST00000371429HSPB11chr154389577-NDC1chr154238162-0.002612930.9973871
ENST00000194214ENST00000371429HSPB11chr154389577-NDC1chr154238162-0.0031420180.996858

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Fusion Genomic Features for HSPB11-NDC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HSPB11-NDC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:54252831/chr1:54395818)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSPB11

Q9Y547

NDC1

Q9BTX1

FUNCTION: Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity). {ECO:0000250|UniProtKB:Q9D6H2}.FUNCTION: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNDC1chr1:54389577chr1:54238162ENST000003714291518136_165600675.0Topological domainPerinuclear space
TgeneNDC1chr1:54389577chr1:54238162ENST000003714291518187_225600675.0Topological domainCytoplasmic
TgeneNDC1chr1:54389577chr1:54238162ENST0000037142915181_24600675.0Topological domainCytoplasmic
TgeneNDC1chr1:54389577chr1:54238162ENST000003714291518247_272600675.0Topological domainPerinuclear space
TgeneNDC1chr1:54389577chr1:54238162ENST000003714291518294_674600675.0Topological domainCytoplasmic
TgeneNDC1chr1:54389577chr1:54238162ENST00000371429151846_68600675.0Topological domainPerinuclear space
TgeneNDC1chr1:54389577chr1:54238162ENST00000371429151890_114600675.0Topological domainCytoplasmic
TgeneNDC1chr1:54389577chr1:54238162ENST000005400011417136_1655631297.0Topological domainPerinuclear space
TgeneNDC1chr1:54389577chr1:54238162ENST000005400011417187_2255631297.0Topological domainCytoplasmic
TgeneNDC1chr1:54389577chr1:54238162ENST0000054000114171_245631297.0Topological domainCytoplasmic
TgeneNDC1chr1:54389577chr1:54238162ENST000005400011417247_2725631297.0Topological domainPerinuclear space
TgeneNDC1chr1:54389577chr1:54238162ENST000005400011417294_6745631297.0Topological domainCytoplasmic
TgeneNDC1chr1:54389577chr1:54238162ENST00000540001141746_685631297.0Topological domainPerinuclear space
TgeneNDC1chr1:54389577chr1:54238162ENST00000540001141790_1145631297.0Topological domainCytoplasmic
TgeneNDC1chr1:54389577chr1:54238162ENST000003714291518115_135600675.0TransmembraneHelical%3B Name%3D3
TgeneNDC1chr1:54389577chr1:54238162ENST000003714291518166_186600675.0TransmembraneHelical%3B Name%3D4
TgeneNDC1chr1:54389577chr1:54238162ENST000003714291518226_246600675.0TransmembraneHelical%3B Name%3D5
TgeneNDC1chr1:54389577chr1:54238162ENST00000371429151825_45600675.0TransmembraneHelical%3B Name%3D1
TgeneNDC1chr1:54389577chr1:54238162ENST000003714291518273_293600675.0TransmembraneHelical%3B Name%3D6
TgeneNDC1chr1:54389577chr1:54238162ENST00000371429151869_89600675.0TransmembraneHelical%3B Name%3D2
TgeneNDC1chr1:54389577chr1:54238162ENST000005400011417115_1355631297.0TransmembraneHelical%3B Name%3D3
TgeneNDC1chr1:54389577chr1:54238162ENST000005400011417166_1865631297.0TransmembraneHelical%3B Name%3D4
TgeneNDC1chr1:54389577chr1:54238162ENST000005400011417226_2465631297.0TransmembraneHelical%3B Name%3D5
TgeneNDC1chr1:54389577chr1:54238162ENST00000540001141725_455631297.0TransmembraneHelical%3B Name%3D1
TgeneNDC1chr1:54389577chr1:54238162ENST000005400011417273_2935631297.0TransmembraneHelical%3B Name%3D6
TgeneNDC1chr1:54389577chr1:54238162ENST00000540001141769_895631297.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for HSPB11-NDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37921_37921_1_HSPB11-NDC1_HSPB11_chr1_54389577_ENST00000194214_NDC1_chr1_54238162_ENST00000371429_length(transcript)=3443nt_BP=708nt
GGGTAGGAGCGAGCGCGCCCGGGAACTCGGTGGAGCGAGCGCGCCCGGGAACTCGGTGGAGGCCGCGGTGGCGGGGTGGGGCGGGGCTGA
GGGCAGGGCGGGGCCTGTGGGAGTCGTGGCGCAAAGAGCTCGGGGTAGGAGCGCGCGCCCGGAAACTCAGCGGTGGCCGCGGCGAAGGGG
CGGGGCTGAGGGTGGGACGGGGCTTGTGGGAGGCGTGGCGCGAAGATTTCAGAGTTGGAGCGCGCGCGACCCCGGACTCCACGGAGGCCG
CGGCGAGCAGGCGGAGCTGCGGGTCGGGACGCTCTGCGTGGGGCGGGGCGCAAGGGAGGTTTCGAGCCCGGAAGGTCCGGCGCCCAGAGC
TAACGGGAGTCCCAGGTTAAACACTTTAAGATGAGAAAAATTGATCTCTGTCTGAGCTCTGAAGGGTCCGAAGTGATTTTAGCTACATCA
AGTGATGAAAAACACCCACCTGAAAATATCATTGATGGGAATCCAGAAACGTTTTGGACCACCACAGGAATGTTTCCCCAGGAATTCATT
ATTTGTTTCCACAAACATGTAAGGATTGAAAGGCTTGTAATCCAAAGTTACTTTGTACAGACCTTGAAGATTGAAAAAAGCACGTCTAAA
GAGCCAGTTGATTTTGAGCAATGGATTGAAAAAGATTTGGTACACACAGAGGGGCAGCTTCAAAATGAAGAAATTGTGGCAGTCGACAAG
TACTTTAAGCTTCCTCATGCTTCCAGTAAACCACCCCGGATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTAAGATTTGCATTC
AGAGCATCACTGAAAACTGCCATCTATCGAATAACTACTACATTTGGTGAACATCTGAATGCTGTGCAAGCATCTGCAGAACATCAGAAA
AGACTTCAACAGTTCTTGGAGTTCAAAGAATAGTTAAGTAATATAAACTGTGTTCATTACACTGCTGATACAACTACAGATGGGACAGTA
AATGTTCAGCATTCTTGGATCAGAAGAAAACGGACTAATTAGATGCTTCCTTTGTCGTGGTGGTTGCTTTGAAAACTATACTTTAATGGG
AGAAATCATGGAAAGAAATTCTCAACAGAATAACTGAAAACTGCCTTTTCTGTACCGATTGCTTTTTGTGTGTGTGGTATAATAAAATCT
TTATTCAATTTTACAGAAGCATTGATGGCAGTCGAAATGTCTCTAGCTCATATAACTTAATAGTAATAACTAAAAAACTTTTAGAATTTA
CTTTTGAAAGGAGGGAAGCCAGTTCTGAAATGAGTATAGGTTGATTTCATAGTCTTCTTAATTAAGAGTTTAGCTCTTTGTAAACTCAAA
ATACATAAACTTTTTAAGTGTAGTTTCATTTACTGAAGGATAAAAATGGTAACAGTGCAGCAATATTCACAAAAAATATTGTCTAACGGA
CATATTTTGTTAATCTGTTAGGTTGGGTTTTTGTTTCCAGGGACAAATTAAATTTGTATGATTACCCAAAAAAGGGTCTCAGTTTACAGA
TGCTAACTCTATATAAAGGAATGTGGAAAAACTCAGTTCTTAAGTTACAAGATTAAAAATTCACATTTGGTCTTTAAGAAACAATTGACT
GACATCTATGAATTTATTTTGTATCATGCTAGTAAACACGAAGTATTAATGTATGGGTATTTTCCCAGCTAGTTTTGCTTTCTTTTTCTG
GAGCAAAACATTAAGTGATTGCAGAGTTTTTCAAGCAAGAGAAAAAGGTTTGCAAAAAAACCCAGGAAATGTTCCCTTTTTTCCCCACCA
TTCATCTTCATTAGATCAAATTCTGTGAAACTTGTCTGGTCTCTCAAAGGGAGCAGCCTCTGTAGTGTTAAATGGCTAATTAAAATAGGA
AGATCTTTATAGCCAGAAACAACTTAGTCATCAAATAGCAAGTGAAACCAAAACGTCAGAGGGATTACTGTACTTGGAAGTATGTTGTGT
GTCCCAAATGTGAACGAAGTATTGTTAGAATTTATTAGATCAGCTTCTTTGGAGATCAAAGATTGGAAATCCTAGTCATAGATATTCACT
GGACTGGCTTTGGACTGAAATGCTCCTTTGTAATTCTTTTCCTATTGTCTTTTCCTTCTAGTGTCCCAAAATATTTTCTTTAAAGTCAGC
ACAGTACTGTATATGAATCTTTAATGTGGTATCATATATGTCTACTTTTGTCTGATTCATCGATGTATTATATCTTTATAATTGAATATT
TTAGCTCCGGGTCCTGTTGCCCCTTCAAGCAGTACATGCCAAATTATAAATAGGTGCTACTGGCCTTGAGCATATCACTGTGGGACAGTT
CCCCAATTGTCAAGTGTTTAGATATGTAGACTATTGCCATTTGTTTTTTTGTTTTGGTTTTGCTTTGTGTCTGAAGCTGAATTGATTTCT
TTTTTTTGAATGTGAAAGTTGAATTTCAAACGTAGTCATTTCTTACAGATGGCCAAGACAGAAAATTGTGGCTAGGTTGACTGAGAACTG
TTGTCTTCCATGTATTAACACAATTAAGCTTTTTATATTCCACTCTCTGTGCTGACCCTGGCTGAGGCATTTTGGGAGACAAGGACTCTG
AATCTTCTGCTTCCATTAAAGAAGAACTGTGATATTCAACATTGGATTTCTGAGAATAAAGATAGGATGATTCCTTTGAACTTTGACTTA
CTTGTATAAAATGTCCAGCTAGGTTAGGTTTTTGCCATTTCCTATATACTTTGGGTAAAGCTACATTTGATGAGCAATGTGAATGTTTCT
GAGAATGTTCATTCCTGTTTTCTCTTAAGAGAATGTGCTGTGTACTAAATACAGGCCACATAGTGTCTGCCTGTTGAAGATCTGGAAACT
GCCTCCCCAGATCTGTATTGTATTTGGTAGGTAAGGGGGTCAGTTTCTTTTTCTCATTGTGTGTTGATAATCTACACACCATCTGTTGGA
ACCAGGGTGTTATTATGGGGAACTCCTCCTGTGTACTAGGAGGAGGACCTTAGGGAGACCAAGAGGAGAGAAGCATTTCCTTTGATGAAG
TCACATCCTGTCTATGAGCCCACTAATGCTGTAACATTGGCCTGAAAGAGAGTGTTCTTTAAAAGCCTTTCTCGGCTGTTAGTATAAAAA
CATGATGGTATCAGCTCTTAGCATGTTTGCTTGACCCTTATGGAAGGTATAAATCCACAGAACTTCCTTCCCAGAGAACTGGGAAATTGT
CCTAGAAATAAACCTTGTACAGTTGAGTGGACATGGATAAGCAACAATTTGTTACTTTGCAGGATTTGTTCCTTGGTAATTGTTTGGTGT
GTCATCCTGTAAATATTCATGATAGTCTGTTTATATCCTTTTGTATATCGTTGATACTGGATTGGGTAGAAAAATAAATTGGCAATTTAA

>37921_37921_1_HSPB11-NDC1_HSPB11_chr1_54389577_ENST00000194214_NDC1_chr1_54238162_ENST00000371429_length(amino acids)=180AA_BP=0
MRKIDLCLSSEGSEVILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFHKHVRIERLVIQSYFVQTLKIEKSTSKEPVDFEQWIE
KDLVHTEGQLQNEEIVAVDKYFKLPHASSKPPRISGSLVDTSYKTLRFAFRASLKTAIYRITTTFGEHLNAVQASAEHQKRLQQFLEFKE

--------------------------------------------------------------
>37921_37921_2_HSPB11-NDC1_HSPB11_chr1_54389577_ENST00000371378_NDC1_chr1_54238162_ENST00000371429_length(transcript)=3086nt_BP=351nt
AGCTAACGGGAGTCCCAGGTTAAACACTTTAAGATGAGAAAAATTGATCTCTGTCTGAGCTCTGAAGGGTCCGAAGTGATTTTAGCTACA
TCAAGTGATGAAAAACACCCACCTGAAAATATCATTGATGGGAATCCAGAAACGTTTTGGACCACCACAGGAATGTTTCCCCAGGAATTC
ATTATTTGTTTCCACAAACATGTAAGGATTGAAAGGCTTGTAATCCAAAGTTACTTTGTACAGACCTTGAAGATTGAAAAAAGCACGTCT
AAAGAGCCAGTTGATTTTGAGCAATGGATTGAAAAAGATTTGGTACACACAGAGGGGCAGCTTCAAAATGAAGAAATTGTGGCAGTCGAC
AAGTACTTTAAGCTTCCTCATGCTTCCAGTAAACCACCCCGGATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTAAGATTTGCA
TTCAGAGCATCACTGAAAACTGCCATCTATCGAATAACTACTACATTTGGTGAACATCTGAATGCTGTGCAAGCATCTGCAGAACATCAG
AAAAGACTTCAACAGTTCTTGGAGTTCAAAGAATAGTTAAGTAATATAAACTGTGTTCATTACACTGCTGATACAACTACAGATGGGACA
GTAAATGTTCAGCATTCTTGGATCAGAAGAAAACGGACTAATTAGATGCTTCCTTTGTCGTGGTGGTTGCTTTGAAAACTATACTTTAAT
GGGAGAAATCATGGAAAGAAATTCTCAACAGAATAACTGAAAACTGCCTTTTCTGTACCGATTGCTTTTTGTGTGTGTGGTATAATAAAA
TCTTTATTCAATTTTACAGAAGCATTGATGGCAGTCGAAATGTCTCTAGCTCATATAACTTAATAGTAATAACTAAAAAACTTTTAGAAT
TTACTTTTGAAAGGAGGGAAGCCAGTTCTGAAATGAGTATAGGTTGATTTCATAGTCTTCTTAATTAAGAGTTTAGCTCTTTGTAAACTC
AAAATACATAAACTTTTTAAGTGTAGTTTCATTTACTGAAGGATAAAAATGGTAACAGTGCAGCAATATTCACAAAAAATATTGTCTAAC
GGACATATTTTGTTAATCTGTTAGGTTGGGTTTTTGTTTCCAGGGACAAATTAAATTTGTATGATTACCCAAAAAAGGGTCTCAGTTTAC
AGATGCTAACTCTATATAAAGGAATGTGGAAAAACTCAGTTCTTAAGTTACAAGATTAAAAATTCACATTTGGTCTTTAAGAAACAATTG
ACTGACATCTATGAATTTATTTTGTATCATGCTAGTAAACACGAAGTATTAATGTATGGGTATTTTCCCAGCTAGTTTTGCTTTCTTTTT
CTGGAGCAAAACATTAAGTGATTGCAGAGTTTTTCAAGCAAGAGAAAAAGGTTTGCAAAAAAACCCAGGAAATGTTCCCTTTTTTCCCCA
CCATTCATCTTCATTAGATCAAATTCTGTGAAACTTGTCTGGTCTCTCAAAGGGAGCAGCCTCTGTAGTGTTAAATGGCTAATTAAAATA
GGAAGATCTTTATAGCCAGAAACAACTTAGTCATCAAATAGCAAGTGAAACCAAAACGTCAGAGGGATTACTGTACTTGGAAGTATGTTG
TGTGTCCCAAATGTGAACGAAGTATTGTTAGAATTTATTAGATCAGCTTCTTTGGAGATCAAAGATTGGAAATCCTAGTCATAGATATTC
ACTGGACTGGCTTTGGACTGAAATGCTCCTTTGTAATTCTTTTCCTATTGTCTTTTCCTTCTAGTGTCCCAAAATATTTTCTTTAAAGTC
AGCACAGTACTGTATATGAATCTTTAATGTGGTATCATATATGTCTACTTTTGTCTGATTCATCGATGTATTATATCTTTATAATTGAAT
ATTTTAGCTCCGGGTCCTGTTGCCCCTTCAAGCAGTACATGCCAAATTATAAATAGGTGCTACTGGCCTTGAGCATATCACTGTGGGACA
GTTCCCCAATTGTCAAGTGTTTAGATATGTAGACTATTGCCATTTGTTTTTTTGTTTTGGTTTTGCTTTGTGTCTGAAGCTGAATTGATT
TCTTTTTTTTGAATGTGAAAGTTGAATTTCAAACGTAGTCATTTCTTACAGATGGCCAAGACAGAAAATTGTGGCTAGGTTGACTGAGAA
CTGTTGTCTTCCATGTATTAACACAATTAAGCTTTTTATATTCCACTCTCTGTGCTGACCCTGGCTGAGGCATTTTGGGAGACAAGGACT
CTGAATCTTCTGCTTCCATTAAAGAAGAACTGTGATATTCAACATTGGATTTCTGAGAATAAAGATAGGATGATTCCTTTGAACTTTGAC
TTACTTGTATAAAATGTCCAGCTAGGTTAGGTTTTTGCCATTTCCTATATACTTTGGGTAAAGCTACATTTGATGAGCAATGTGAATGTT
TCTGAGAATGTTCATTCCTGTTTTCTCTTAAGAGAATGTGCTGTGTACTAAATACAGGCCACATAGTGTCTGCCTGTTGAAGATCTGGAA
ACTGCCTCCCCAGATCTGTATTGTATTTGGTAGGTAAGGGGGTCAGTTTCTTTTTCTCATTGTGTGTTGATAATCTACACACCATCTGTT
GGAACCAGGGTGTTATTATGGGGAACTCCTCCTGTGTACTAGGAGGAGGACCTTAGGGAGACCAAGAGGAGAGAAGCATTTCCTTTGATG
AAGTCACATCCTGTCTATGAGCCCACTAATGCTGTAACATTGGCCTGAAAGAGAGTGTTCTTTAAAAGCCTTTCTCGGCTGTTAGTATAA
AAACATGATGGTATCAGCTCTTAGCATGTTTGCTTGACCCTTATGGAAGGTATAAATCCACAGAACTTCCTTCCCAGAGAACTGGGAAAT
TGTCCTAGAAATAAACCTTGTACAGTTGAGTGGACATGGATAAGCAACAATTTGTTACTTTGCAGGATTTGTTCCTTGGTAATTGTTTGG
TGTGTCATCCTGTAAATATTCATGATAGTCTGTTTATATCCTTTTGTATATCGTTGATACTGGATTGGGTAGAAAAATAAATTGGCAATT

>37921_37921_2_HSPB11-NDC1_HSPB11_chr1_54389577_ENST00000371378_NDC1_chr1_54238162_ENST00000371429_length(amino acids)=180AA_BP=0
MRKIDLCLSSEGSEVILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFHKHVRIERLVIQSYFVQTLKIEKSTSKEPVDFEQWIE
KDLVHTEGQLQNEEIVAVDKYFKLPHASSKPPRISGSLVDTSYKTLRFAFRASLKTAIYRITTTFGEHLNAVQASAEHQKRLQQFLEFKE

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Fusion Gene PPI Analysis for HSPB11-NDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSPB11-NDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HSPB11-NDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource