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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HSPB1-CAMKK2 (FusionGDB2 ID:37929)

Fusion Gene Summary for HSPB1-CAMKK2

check button Fusion gene summary
Fusion gene informationFusion gene name: HSPB1-CAMKK2
Fusion gene ID: 37929
HgeneTgene
Gene symbol

HSPB1

CAMKK2

Gene ID

3315

10645

Gene nameheat shock protein family B (small) member 1calcium/calmodulin dependent protein kinase kinase 2
SynonymsCMT2F|HEL-S-102|HMN2B|HS.76067|HSP27|HSP28|Hsp25|SRP27CAMKK|CAMKKB
Cytomap

7q11.23

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionheat shock protein beta-128 kDa heat shock proteinepididymis secretory protein Li 102estrogen-regulated 24 kDa proteinheat shock 27 kDa proteinheat shock 27kD protein 1heat shock 27kDa protein 1stress-responsive protein 27calcium/calmodulin-dependent protein kinase kinase 2CAMKK beta proteincaM-KK 2caM-KK betacaM-kinase kinase 2caM-kinase kinase betacalcium/calmodulin-dependent protein kinase betacalcium/calmodulin-dependent protein kinase kinase 2, beta
Modification date2020032720200313
UniProtAcc

P04792

Q96RR4

Ensembl transtripts involved in fusion geneENST00000248553, ENST00000429938, 
ENST00000324774, ENST00000337174, 
ENST00000347034, ENST00000392473, 
ENST00000402834, ENST00000404169, 
ENST00000412367, ENST00000446440, 
ENST00000535524, ENST00000538733, 
ENST00000545538, ENST00000392474, 
Fusion gene scores* DoF score24 X 17 X 8=32644 X 4 X 3=48
# samples 264
** MAII scorelog2(26/3264*10)=-3.65005752894304
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSPB1 [Title/Abstract] AND CAMKK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSPB1(75933612)-CAMKK2(121682418), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAMKK2

GO:0006468

protein phosphorylation

11395482

TgeneCAMKK2

GO:0046777

protein autophosphorylation

11395482


check buttonFusion gene breakpoints across HSPB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAMKK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-XA-A8JR-01AHSPB1chr7

75933612

-CAMKK2chr12

121682418

-


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Fusion Gene ORF analysis for HSPB1-CAMKK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000248553ENST00000324774HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000337174HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000347034HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000392473HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000402834HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000404169HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000412367HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000446440HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000535524HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000538733HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000545538HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000324774HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000337174HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000347034HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000392473HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000402834HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000404169HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000412367HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000446440HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000535524HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000538733HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000545538HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
In-frameENST00000248553ENST00000392474HSPB1chr7

75933612

-CAMKK2chr12

121682418

-
In-frameENST00000429938ENST00000392474HSPB1chr7

75933612

-CAMKK2chr12

121682418

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000248553HSPB1chr775933612-ENST00000392474CAMKK2chr12121682418-380190991786231
ENST00000429938HSPB1chr775933612-ENST00000392474CAMKK2chr12121682418-3419527682182166

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000248553ENST00000392474HSPB1chr775933612-CAMKK2chr12121682418-0.104167840.8958321
ENST00000429938ENST00000392474HSPB1chr775933612-CAMKK2chr12121682418-0.925138060.0748619

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Fusion Genomic Features for HSPB1-CAMKK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HSPB1-CAMKK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:75933612/chr12:121682418)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSPB1

P04792

CAMKK2

Q96RR4

FUNCTION: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}.FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSPB1chr7:75933612chr12:121682418ENST00000248553-3376_184246206.0DomainsHSP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000337174016165_4460542.0DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000412367016165_4460542.0DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000538733015165_4460499.0DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000337174016171_1790542.0Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000412367016171_1790542.0Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000538733015171_1790499.0Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000337174016204_2260542.0RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000337174016472_4770542.0RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000337174016475_5000542.0RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003470341316472_477474546.0RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003470341316475_500474546.0RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000412367016204_2260542.0RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000412367016472_4770542.0RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000412367016475_5000542.0RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004464401316472_477474491.0RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004464401316475_500474491.0RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000538733015204_2260499.0RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000538733015472_4770499.0RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000538733015475_5000499.0RegionCalmodulin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003247741417165_446517589.0DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003470341316165_446474546.0DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003924731417165_446517534.0DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003924741316165_446517557.0DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004028341417165_446517589.0DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004041691417165_446517589.0DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004464401316165_446474491.0DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003247741417171_179517589.0Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003470341316171_179474546.0Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003924731417171_179517534.0Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003924741316171_179517557.0Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004028341417171_179517589.0Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004041691417171_179517589.0Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004464401316171_179474491.0Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003247741417204_226517589.0RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003247741417472_477517589.0RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003247741417475_500517589.0RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003470341316204_226474546.0RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003924731417204_226517534.0RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003924731417472_477517534.0RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003924731417475_500517534.0RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003924741316204_226517557.0RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003924741316472_477517557.0RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000003924741316475_500517557.0RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004028341417204_226517589.0RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004028341417472_477517589.0RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004028341417475_500517589.0RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004041691417204_226517589.0RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004041691417472_477517589.0RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004041691417475_500517589.0RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST000004464401316204_226474491.0RegionNote=RP domain


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Fusion Gene Sequence for HSPB1-CAMKK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37929_37929_1_HSPB1-CAMKK2_HSPB1_chr7_75933612_ENST00000248553_CAMKK2_chr12_121682418_ENST00000392474_length(transcript)=3801nt_BP=909nt
GCTGGGGGAGGAGTGCATGGGGAGGGGCGGCCCTCAAACGGGTCATTGCCATTAATAGAGACCTCAAACACCGCCTGCTAAAAATACCCG
ACTGGAGGAGCATAAAAGCGCAGCCGAGCCCAGCGCCCCGCACTTTTCTGAGCAGACGTCCAGAGCAGAGTCAGCCAGCATGACCGAGCG
CCGCGTCCCCTTCTCGCTCCTGCGGGGCCCCAGCTGGGACCCCTTCCGCGACTGGTACCCGCATAGCCGCCTCTTCGACCAGGCCTTCGG
GCTGCCCCGGCTGCCGGAGGAGTGGTCGCAGTGGTTAGGCGGCAGCAGCTGGCCAGGCTACGTGCGCCCCCTGCCCCCCGCCGCCATCGA
GAGCCCCGCAGTGGCCGCGCCCGCCTACAGCCGCGCGCTCAGCCGGCAACTCAGCAGCGGGGTCTCGGAGATCCGGCACACTGCGGACCG
CTGGCGCGTGTCCCTGGATGTCAACCACTTCGCCCCGGACGAGCTGACGGTCAAGACCAAGGATGGCGTGGTGGAGATCACCGGCAAGCA
CGAGGAGCGGCAGGACGAGCATGGCTACATCTCCCGGTGCTTCACGCGGAAATACACGCTGCCCCCCGGTGTGGACCCCACCCAAGTTTC
CTCCTCCCTGTCCCCTGAGGGCACACTGACCGTGGAGGCCCCCATGCCCAAGCTAGCCACGCAGTCCAACGAGATCACCATCCCAGTCAC
CTTCGAGTCGCGGGCCCAGCTTGGGGGCCCAGAAGCTGCAAAATCCGATGAGACTGCCGCCAAGTAAAGCCTTAGCCCGGATGCCCACCC
CTGCTGCCGCCACTGGCTGTGCCTCCCCCGCCACCTGTGTGTTCTTTTGATACATTTATCTTCTGTTTTTCTCAAATAAAGTTCAAAGCA
ACCACCTGTCAAAAAACCAACCAGGGAATGTGAGTCCCTGTCTGAGCTCAAGGGGACAAAAAAAAAAAAAGGACTTGACTCCATGACGTC
GACCGTGGCCGCTGGCTGGCTGGACAGGCGGGTGTGAGGAGTTGCAGACCCAAACCCACGTGCATTTTGGGACAATTGCTTTTTAAAACG
TTTTTATGCCAAAAATCCTTCATTGTGATTTTCAGAACCACGTCAGATATACCAAGTGACTGTGTGTGGGGTTTGACAACTGTGGAAAGG
CGAGCAGAAAACTCCGGCGGTCTGAGGCCATGGAGGTGGTTGCTGCATTTGAGAGGGAGTAGGGGGCTAGATGTGGCTCCTAGTGCAAAC
CGGAAACCATGGCACCTTCCAGAGCCGTGGTCTCAAGGAGTCAGAGCAGGGCTGGCCCTCAGTAGCTGCAGGGAGCTTTGATGCAACTTA
TTTGTAAGAAGGATTTTTAAATTTTTTATGGGTAGAATTGTAGTCAGGAAAACAGAAAGGGCTTGAAATTTAATAAGTGCTGCTGGAAGG
GGATTTTCCAAGCCTGGAAGGGTATTCAGCAGCTGTGGTGGGGAAACATTTCTCCTGAAAGACTGAACGTGTTTCTTCATGACAGCTGCT
CAAAGCAGGTTTCTGAGATAGCTGACCGAGCTCTGGTAAATCTCTTTGTCAAATTACGAAAACTTCAGGGTGAAATCCTATGCTTCCATG
TACATTACATGGCTTAAGATTAAACAAAAACATTTTTCAAGTCTCTAACTAGAGTGAACTCTAGAGCACAGTAGTTCAGAAACTATTTAG
AGCTTCCAGGATATATTTCACAGCTTCAGGCATGTGATCAGTTAGAGCCGATGAAACCTATGCCCGCCTGTATATATATTAGCAGCTTAG
CTAGTTCATAACCTGTATATTCTAAAGACTGCTAAGGTTTTGTTTTCATTTTAAATCCTAGCTGATTGTTGTGGTCAATGAAATACCCAG
TTTCTGGAGGGCCAGGTGGGAAATGCTTTCACTGGACCAACACACAAATGATCATCCTGAGGATCTGAGCTTCCCTAGACTCCACACAAT
AACCTTGGGGCACCCTTTTAGAGAAGACTGTTGAAACCCACAGCACTCGTTGGGGTATGAGGAAACCAGGGCTTGGCACAGGAAGTTCCC
CTTTGTAGCTAAAAGTCCAGAAAGAAAGGGTTCATCTTTTTGACTTCCAACTGATATTGGGAAGTTTGGTTGAGGTTCAAGTGTGACTCC
TTCCAGAGCCACAGGTAGGGGAGTGTGAAGTTGAGGGGGAGGAAAGCTGGAAGGACTCTGCCTTGGGAGATTCCCAGCTCTGCTTTCCAG
CGCTTGGTGGAATCTGGGCTGGGGAAAGACGGCACCGGGAAACTCTGCTTCCCCATTGTTTCCATCTGATCAGCTGTGGTGTGAGGACTT
CTCAGACAAAGGCAAGGCCTCGTGCCCCTGCCCAGCCCATTCATGGAGCCCTGGGCCTTCTTGGCTTCCATAGATCCTAAGCTCTTGACT
GTAGTTTAGCCAGACTTGTTTTGCTATCTTATAAGCAGTTCAGAATTAGGGAATGCTGGTTTTGAAGAGCAAAGGACAGGTAGTCTAGAG
AGGGTCGTCTGGCCTGCTTGCTGGGTCTTTGTAACCCAGCACTTCCTCTTGCCCTCCTGGCTTTATGTTTATGGGGAGAGGACTCAATAG
CTCCACCCCTTCTGGCACCAGATGGGGCTTGGTTAGTTTGCAATAAGCACCTTGCAGAGGTTAAAGCCAGCGGGTCCCTAGTCTTAGGCC
CAGCCTGCTTGTGTGGGCTCTGGCCTGGCCTGGTGGCTGGCCCAGGGGGCAGCAGTGCTTAGAGCTTCTGCAGGGCTTCTCTTGTTTACA
CAGCTGCATCAGACAATGCCATTTCTCCCCACCACGGAACCTTCCATCTAAGATTTCTTCCAGGGAATGCCAGCAATCAGGCAGCACCCA
GCTGTGGGGGCAGTGGGGTGGGGGAGACCCACATTGATGACTTTTTTTTTTTCTTTTAATGAAGAAACACCAAAGAAAGCTGTGGAAAGG
ACCTGCCCCACATGAAAAGGATAAGCCAAGATGGCTGTAAACACAGAGCATTTGAGCTGCCACTCTTGGAGCACATTGATTTTTCAAAAG
CCAGCTCTGTCAGGAAAGGAGGTGCTGTTATGAGCAGCTCTTCCAGTGGGCAAAGAGGACGCCCATAATTTCTTCCATTGCTAGCTCATC
TGTGGGACCAATTTGGTGTAAGCAACCTGTGGCCTGCACTTGTGGCCTCGAAGGAAGCACAAACCCTCCATCCACTTCCCATTTCCTCTG
CCCTTTTCCACCTCCCCCTTCCATCCCACCAGCTGCCAGTGGCTCCCAGAAAGCCTTATTGAGCCCCTTGTTGACACTTGGGGCTGCGGA
GGCCTCTCCCTACTGGTCTGGCCTTTCCTGAGAGGCAGGTCTTCCGTCCTCAGAGCCTTTCTGGAACAAGGAGAATGCCTGTGCAGGTGG
ACACACAGGCCTGGCCTGTCGCTCTCACTTGTCTTCCAGCGGGGAGCTTCACGTTGCCGAGTGGAAGAACCATGACCTCCACTTGCTTCC
AAGGTGCTAGGGAAGTTTCAGGGTACGCTGGTTCCCCTCTCCAGCTGGAGGCCGAGTTTCTGGGGACTGCAGATTTTTCTACTCTGTGAT
CGATTCAATGCCCGATGCTTCTGTTTCATTCCCGACCCTTTCTACTATGCATTTTCCTTTTATCAGGTGTATAAAGTTAAATACTGTGTA
TTTATCACTAAAAAGTACATGAACTTAAGAGACAACTAAGCCTTTCGTGTTTTTCCACAGGTGTTTAAGCTTCTCTGTACAGTTGAAATA

>37929_37929_1_HSPB1-CAMKK2_HSPB1_chr7_75933612_ENST00000248553_CAMKK2_chr12_121682418_ENST00000392474_length(amino acids)=231AA_BP=
MEEHKSAAEPSAPHFSEQTSRAESASMTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPLPPAAIE
SPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVS

--------------------------------------------------------------
>37929_37929_2_HSPB1-CAMKK2_HSPB1_chr7_75933612_ENST00000429938_CAMKK2_chr12_121682418_ENST00000392474_length(transcript)=3419nt_BP=527nt
AGCTCCGCGCCCTGCTCCGTTCCTCCCAAAACTCTGAATCGAAGAACTTTCCGGAAGTTTCTGAGAGCCCAGACCGGCGGGCACGCCCCC
ATCCCCAACCCCCTCTGTTAATCCCTACCAGCCTGCAGTCCTGGCTGCTTCCAAGCAGGAGGCAAGCACGAGGAGCGGCAGGACGAGCAT
GGCTACATCTCCCGGTGCTTCACGCGGAAATACACGCTGCCCCCCGGTGTGGACCCCACCCAAGTTTCCTCCTCCCTGTCCCCTGAGGGC
ACACTGACCGTGGAGGCCCCCATGCCCAAGCTAGCCACGCAGTCCAACGAGATCACCATCCCAGTCACCTTCGAGTCGCGGGCCCAGCTT
GGGGGCCCAGAAGCTGCAAAATCCGATGAGACTGCCGCCAAGTAAAGCCTTAGCCCGGATGCCCACCCCTGCTGCCGCCACTGGCTGTGC
CTCCCCCGCCACCTGTGTGTTCTTTTGATACATTTATCTTCTGTTTTTCTCAAATAAAGTTCAAAGCAACCACCTGTCAAAAAACCAACC
AGGGAATGTGAGTCCCTGTCTGAGCTCAAGGGGACAAAAAAAAAAAAAGGACTTGACTCCATGACGTCGACCGTGGCCGCTGGCTGGCTG
GACAGGCGGGTGTGAGGAGTTGCAGACCCAAACCCACGTGCATTTTGGGACAATTGCTTTTTAAAACGTTTTTATGCCAAAAATCCTTCA
TTGTGATTTTCAGAACCACGTCAGATATACCAAGTGACTGTGTGTGGGGTTTGACAACTGTGGAAAGGCGAGCAGAAAACTCCGGCGGTC
TGAGGCCATGGAGGTGGTTGCTGCATTTGAGAGGGAGTAGGGGGCTAGATGTGGCTCCTAGTGCAAACCGGAAACCATGGCACCTTCCAG
AGCCGTGGTCTCAAGGAGTCAGAGCAGGGCTGGCCCTCAGTAGCTGCAGGGAGCTTTGATGCAACTTATTTGTAAGAAGGATTTTTAAAT
TTTTTATGGGTAGAATTGTAGTCAGGAAAACAGAAAGGGCTTGAAATTTAATAAGTGCTGCTGGAAGGGGATTTTCCAAGCCTGGAAGGG
TATTCAGCAGCTGTGGTGGGGAAACATTTCTCCTGAAAGACTGAACGTGTTTCTTCATGACAGCTGCTCAAAGCAGGTTTCTGAGATAGC
TGACCGAGCTCTGGTAAATCTCTTTGTCAAATTACGAAAACTTCAGGGTGAAATCCTATGCTTCCATGTACATTACATGGCTTAAGATTA
AACAAAAACATTTTTCAAGTCTCTAACTAGAGTGAACTCTAGAGCACAGTAGTTCAGAAACTATTTAGAGCTTCCAGGATATATTTCACA
GCTTCAGGCATGTGATCAGTTAGAGCCGATGAAACCTATGCCCGCCTGTATATATATTAGCAGCTTAGCTAGTTCATAACCTGTATATTC
TAAAGACTGCTAAGGTTTTGTTTTCATTTTAAATCCTAGCTGATTGTTGTGGTCAATGAAATACCCAGTTTCTGGAGGGCCAGGTGGGAA
ATGCTTTCACTGGACCAACACACAAATGATCATCCTGAGGATCTGAGCTTCCCTAGACTCCACACAATAACCTTGGGGCACCCTTTTAGA
GAAGACTGTTGAAACCCACAGCACTCGTTGGGGTATGAGGAAACCAGGGCTTGGCACAGGAAGTTCCCCTTTGTAGCTAAAAGTCCAGAA
AGAAAGGGTTCATCTTTTTGACTTCCAACTGATATTGGGAAGTTTGGTTGAGGTTCAAGTGTGACTCCTTCCAGAGCCACAGGTAGGGGA
GTGTGAAGTTGAGGGGGAGGAAAGCTGGAAGGACTCTGCCTTGGGAGATTCCCAGCTCTGCTTTCCAGCGCTTGGTGGAATCTGGGCTGG
GGAAAGACGGCACCGGGAAACTCTGCTTCCCCATTGTTTCCATCTGATCAGCTGTGGTGTGAGGACTTCTCAGACAAAGGCAAGGCCTCG
TGCCCCTGCCCAGCCCATTCATGGAGCCCTGGGCCTTCTTGGCTTCCATAGATCCTAAGCTCTTGACTGTAGTTTAGCCAGACTTGTTTT
GCTATCTTATAAGCAGTTCAGAATTAGGGAATGCTGGTTTTGAAGAGCAAAGGACAGGTAGTCTAGAGAGGGTCGTCTGGCCTGCTTGCT
GGGTCTTTGTAACCCAGCACTTCCTCTTGCCCTCCTGGCTTTATGTTTATGGGGAGAGGACTCAATAGCTCCACCCCTTCTGGCACCAGA
TGGGGCTTGGTTAGTTTGCAATAAGCACCTTGCAGAGGTTAAAGCCAGCGGGTCCCTAGTCTTAGGCCCAGCCTGCTTGTGTGGGCTCTG
GCCTGGCCTGGTGGCTGGCCCAGGGGGCAGCAGTGCTTAGAGCTTCTGCAGGGCTTCTCTTGTTTACACAGCTGCATCAGACAATGCCAT
TTCTCCCCACCACGGAACCTTCCATCTAAGATTTCTTCCAGGGAATGCCAGCAATCAGGCAGCACCCAGCTGTGGGGGCAGTGGGGTGGG
GGAGACCCACATTGATGACTTTTTTTTTTTCTTTTAATGAAGAAACACCAAAGAAAGCTGTGGAAAGGACCTGCCCCACATGAAAAGGAT
AAGCCAAGATGGCTGTAAACACAGAGCATTTGAGCTGCCACTCTTGGAGCACATTGATTTTTCAAAAGCCAGCTCTGTCAGGAAAGGAGG
TGCTGTTATGAGCAGCTCTTCCAGTGGGCAAAGAGGACGCCCATAATTTCTTCCATTGCTAGCTCATCTGTGGGACCAATTTGGTGTAAG
CAACCTGTGGCCTGCACTTGTGGCCTCGAAGGAAGCACAAACCCTCCATCCACTTCCCATTTCCTCTGCCCTTTTCCACCTCCCCCTTCC
ATCCCACCAGCTGCCAGTGGCTCCCAGAAAGCCTTATTGAGCCCCTTGTTGACACTTGGGGCTGCGGAGGCCTCTCCCTACTGGTCTGGC
CTTTCCTGAGAGGCAGGTCTTCCGTCCTCAGAGCCTTTCTGGAACAAGGAGAATGCCTGTGCAGGTGGACACACAGGCCTGGCCTGTCGC
TCTCACTTGTCTTCCAGCGGGGAGCTTCACGTTGCCGAGTGGAAGAACCATGACCTCCACTTGCTTCCAAGGTGCTAGGGAAGTTTCAGG
GTACGCTGGTTCCCCTCTCCAGCTGGAGGCCGAGTTTCTGGGGACTGCAGATTTTTCTACTCTGTGATCGATTCAATGCCCGATGCTTCT
GTTTCATTCCCGACCCTTTCTACTATGCATTTTCCTTTTATCAGGTGTATAAAGTTAAATACTGTGTATTTATCACTAAAAAGTACATGA

>37929_37929_2_HSPB1-CAMKK2_HSPB1_chr7_75933612_ENST00000429938_CAMKK2_chr12_121682418_ENST00000392474_length(amino acids)=166AA_BP=1
MSQNARGFGSATPHTRLSSQPAATVDVMESSPFFFFVPLSSDRDSHSLVGFLTGGCFELYLRKTEDKCIKRTHRWRGRHSQWRQQGWASG

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Fusion Gene PPI Analysis for HSPB1-CAMKK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneHSPB1chr7:75933612chr12:121682418ENST00000248553-3370_205246.66666666666666206.0TGFB1I1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSPB1-CAMKK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HSPB1-CAMKK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource