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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:HSPB1-EGR1 (FusionGDB2 ID:37933) |
Fusion Gene Summary for HSPB1-EGR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HSPB1-EGR1 | Fusion gene ID: 37933 | Hgene | Tgene | Gene symbol | HSPB1 | EGR1 | Gene ID | 3315 | 1958 |
| Gene name | heat shock protein family B (small) member 1 | early growth response 1 | |
| Synonyms | CMT2F|HEL-S-102|HMN2B|HS.76067|HSP27|HSP28|Hsp25|SRP27 | AT225|G0S30|KROX-24|NGFI-A|TIS8|ZIF-268|ZNF225 | |
| Cytomap | 7q11.23 | 5q31.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heat shock protein beta-128 kDa heat shock proteinepididymis secretory protein Li 102estrogen-regulated 24 kDa proteinheat shock 27 kDa proteinheat shock 27kD protein 1heat shock 27kDa protein 1stress-responsive protein 27 | early growth response protein 1EGR-1nerve growth factor-induced protein Atranscription factor ETR103transcription factor Zif268zinc finger protein 225zinc finger protein Krox-24 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | P04792 | P18146 | |
| Ensembl transtripts involved in fusion gene | ENST00000248553, ENST00000429938, | ENST00000239938, | |
| Fusion gene scores | * DoF score | 24 X 17 X 8=3264 | 7 X 10 X 3=210 |
| # samples | 26 | 11 | |
| ** MAII score | log2(26/3264*10)=-3.65005752894304 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/210*10)=-0.932885804141463 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HSPB1 [Title/Abstract] AND EGR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | HSPB1(75933420)-EGR1(137802972), # samples:1 HSPB1(75933533)-EGR1(137802528), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | EGR1 | GO:0006366 | transcription by RNA polymerase II | 19057511 |
| Tgene | EGR1 | GO:0033233 | regulation of protein sumoylation | 19057511 |
| Tgene | EGR1 | GO:0045893 | positive regulation of transcription, DNA-templated | 12560508 |
| Tgene | EGR1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19057511 |
| Tgene | EGR1 | GO:0098759 | cellular response to interleukin-8 | 20363028 |
| Tgene | EGR1 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 19307576 |
| Fusion gene breakpoints across HSPB1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across EGR1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-GI-A2C9-11A | HSPB1 | chr7 | 75933420 | + | EGR1 | chr5 | 137802972 | + |
| ChiTaRS5.0 | N/A | AA903814 | HSPB1 | chr7 | 75933533 | - | EGR1 | chr5 | 137802528 | - |
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Fusion Gene ORF analysis for HSPB1-EGR1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000248553 | ENST00000239938 | HSPB1 | chr7 | 75933533 | - | EGR1 | chr5 | 137802528 | - |
| 3UTR-3CDS | ENST00000429938 | ENST00000239938 | HSPB1 | chr7 | 75933533 | - | EGR1 | chr5 | 137802528 | - |
| In-frame | ENST00000248553 | ENST00000239938 | HSPB1 | chr7 | 75933420 | + | EGR1 | chr5 | 137802972 | + |
| In-frame | ENST00000429938 | ENST00000239938 | HSPB1 | chr7 | 75933420 | + | EGR1 | chr5 | 137802972 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000248553 | HSPB1 | chr7 | 75933420 | + | ENST00000239938 | EGR1 | chr5 | 137802972 | + | 2821 | 789 | 690 | 1586 | 298 |
| ENST00000429938 | HSPB1 | chr7 | 75933420 | + | ENST00000239938 | EGR1 | chr5 | 137802972 | + | 2439 | 407 | 308 | 1204 | 298 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000248553 | ENST00000239938 | HSPB1 | chr7 | 75933420 | + | EGR1 | chr5 | 137802972 | + | 0.51534647 | 0.48465356 |
| ENST00000429938 | ENST00000239938 | HSPB1 | chr7 | 75933420 | + | EGR1 | chr5 | 137802972 | + | 0.35648906 | 0.64351094 |
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Fusion Genomic Features for HSPB1-EGR1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for HSPB1-EGR1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:75933420/chr5:137802972) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HSPB1 | EGR1 |
| FUNCTION: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. | FUNCTION: Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). {ECO:0000250|UniProtKB:P08046, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | EGR1 | chr7:75933420 | chr5:137802972 | ENST00000239938 | 0 | 2 | 57_84 | 0 | 544.0 | Compositional bias | Note=Gly/Ser-rich | |
| Tgene | EGR1 | chr7:75933420 | chr5:137802972 | ENST00000239938 | 0 | 2 | 338_362 | 0 | 544.0 | Zinc finger | C2H2-type 1 | |
| Tgene | EGR1 | chr7:75933420 | chr5:137802972 | ENST00000239938 | 0 | 2 | 368_390 | 0 | 544.0 | Zinc finger | C2H2-type 2 | |
| Tgene | EGR1 | chr7:75933420 | chr5:137802972 | ENST00000239938 | 0 | 2 | 396_418 | 0 | 544.0 | Zinc finger | C2H2-type 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HSPB1 | chr7:75933420 | chr5:137802972 | ENST00000248553 | + | 1 | 3 | 76_184 | 0 | 206.0 | Domain | sHSP |
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Fusion Gene Sequence for HSPB1-EGR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >37933_37933_1_HSPB1-EGR1_HSPB1_chr7_75933420_ENST00000248553_EGR1_chr5_137802972_ENST00000239938_length(transcript)=2821nt_BP=789nt GCTGGGGGAGGAGTGCATGGGGAGGGGCGGCCCTCAAACGGGTCATTGCCATTAATAGAGACCTCAAACACCGCCTGCTAAAAATACCCG ACTGGAGGAGCATAAAAGCGCAGCCGAGCCCAGCGCCCCGCACTTTTCTGAGCAGACGTCCAGAGCAGAGTCAGCCAGCATGACCGAGCG CCGCGTCCCCTTCTCGCTCCTGCGGGGCCCCAGCTGGGACCCCTTCCGCGACTGGTACCCGCATAGCCGCCTCTTCGACCAGGCCTTCGG GCTGCCCCGGCTGCCGGAGGAGTGGTCGCAGTGGTTAGGCGGCAGCAGCTGGCCAGGCTACGTGCGCCCCCTGCCCCCCGCCGCCATCGA GAGCCCCGCAGTGGCCGCGCCCGCCTACAGCCGCGCGCTCAGCCGGCAACTCAGCAGCGGGGTCTCGGAGATCCGGCACACTGCGGACCG CTGGCGCGTGTCCCTGGATGTCAACCACTTCGCCCCGGACGAGCTGACGGTCAAGACCAAGGATGGCGTGGTGGAGATCACCGGCAAGCA CGAGGAGCGGCAGGACGAGCATGGCTACATCTCCCGGTGCTTCACGCGGAAATACACCACCTTCGAGTCGCGGGCCCAGCTTGGGGGCCC AGAAGCTGCAAAATCCGATGAGACTGCCGCCAAGTAAAGCCTTAGCCCGGATGCCCACCCCTGCTGCCGCCACTGGCTGTGCCTCCCCCG CCACCTGTGTGTTCTTTTGATACATTTATCTTCTGTTTTTCTCAAATAAAGTTCAAAGCAACCACCTGTAGCCGCACCCAGCAGCCTTCG CTAACCCCTCTGTCTACTATTAAGGCCTTTGCCACTCAGTCGGGCTCCCAGGACCTGAAGGCCCTCAATACCAGCTACCAGTCCCAGCTC ATCAAACCCAGCCGCATGCGCAAGTACCCCAACCGGCCCAGCAAGACGCCCCCCCACGAACGCCCTTACGCTTGCCCAGTGGAGTCCTGT GATCGCCGCTTCTCCCGCTCCGACGAGCTCACCCGCCACATCCGCATCCACACAGGCCAGAAGCCCTTCCAGTGCCGCATCTGCATGCGC AACTTCAGCCGCAGCGACCACCTCACCACCCACATCCGCACCCACACAGGCGAAAAGCCCTTCGCCTGCGACATCTGTGGAAGAAAGTTT GCCAGGAGCGATGAACGCAAGAGGCATACCAAGATCCACTTGCGGCAGAAGGACAAGAAAGCAGACAAAAGTGTTGTGGCCTCTTCGGCC ACCTCCTCTCTCTCTTCCTACCCGTCCCCGGTTGCTACCTCTTACCCGTCCCCGGTTACTACCTCTTATCCATCCCCGGCCACCACCTCA TACCCATCCCCTGTGCCCACCTCCTTCTCCTCTCCCGGCTCCTCGACCTACCCATCCCCTGTGCACAGTGGCTTCCCCTCCCCGTCGGTG GCCACCACGTACTCCTCTGTTCCCCCTGCTTTCCCGGCCCAGGTCAGCAGCTTCCCTTCCTCAGCTGTCACCAACTCCTTCAGCGCCTCC ACAGGGCTTTCGGACATGACAGCAACCTTTTCTCCCAGGACAATTGAAATTTGCTAAAGGGAAAGGGGAAAGAAAGGGAAAAGGGAGAAA AAGAAACACAAGAGACTTAAAGGACAGGAGGAGGAGATGGCCATAGGAGAGGAGGGTTCCTCTTAGGTCAGATGGAGGTTCTCAGAGCCA AGTCCTCCCTCTCTACTGGAGTGGAAGGTCTATTGGCCAACAATCCTTTCTGCCCACTTCCCCTTCCCCAATTACTATTCCCTTTGACTT CAGCTGCCTGAAACAGCCATGTCCAAGTTCTTCACCTCTATCCAAAGAACTTGATTTGCATGGATTTTGGATAAATCATTTCAGTATCAT CTCCATCATATGCCTGACCCCTTGCTCCCTTCAATGCTAGAAAATCGAGTTGGCAAAATGGGGTTTGGGCCCCTCAGAGCCCTGCCCTGC ACCCTTGTACAGTGTCTGTGCCATGGATTTCGTTTTTCTTGGGGTACTCTTGATGTGAAGATAATTTGCATATTCTATTGTATTATTTGG AGTTAGGTCCTCACTTGGGGGAAAAAAAAAAAAGAAAAGCCAAGCAAACCAATGGTGATCCTCTATTTTGTGATGATGCTGTGACAATAA GTTTGAACCTTTTTTTTTGAAACAGCAGTCCCAGTATTCTCAGAGCATGTGTCAGAGTGTTGTTCCGTTAACCTTTTTGTAAATACTGCT TGACCGTACTCTCACATGTGGCAAAATATGGTTTGGTTTTTCTTTTTTTTTTTTTTTGAAAGTGTTTTTTCTTCGTCCTTTTGGTTTAAA AAGTTTCACGTCTTGGTGCCTTTTGTGTGATGCGCCTTGCTGATGGCTTGACATGTGCAATTGTGAGGGACATGCTCACCTCTAGCCTTA AGGGGGGCAGGGAGTGATGATTTGGGGGAGGCTTTGGGAGCAAAATAAGGAAGAGGGCTGAGCTGAGCTTCGGTTCTCCAGAATGTAAGA AAACAAAATCTAAAACAAAATCTGAACTCTCAAAAGTCTATTTTTTTAACTGAAAATGTAAATTTATAAATATATTCAGGAGTTGGAATG TTGTAGTTACCTACTGAGTAGGCGGCGATTTTTGTATGTTATGAACATGCAGTTCATTATTTTGTGGTTCTATTTTACTTTGTACTTGTG TTTGCTTAAACAAAGTGACTGTTTGGCTTATAAACACATTGAATGCGCTTTATTGCCCATGGGATATGTGGTGTATATCCTTCCAAAAAA >37933_37933_1_HSPB1-EGR1_HSPB1_chr7_75933420_ENST00000248553_EGR1_chr5_137802972_ENST00000239938_length(amino acids)=298AA_BP=33 MLPPLAVPPPPPVCSFDTFIFCFSQIKFKATTCSRTQQPSLTPLSTIKAFATQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHE RPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKK ADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSSTYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPS -------------------------------------------------------------- >37933_37933_2_HSPB1-EGR1_HSPB1_chr7_75933420_ENST00000429938_EGR1_chr5_137802972_ENST00000239938_length(transcript)=2439nt_BP=407nt AGCTCCGCGCCCTGCTCCGTTCCTCCCAAAACTCTGAATCGAAGAACTTTCCGGAAGTTTCTGAGAGCCCAGACCGGCGGGCACGCCCCC ATCCCCAACCCCCTCTGTTAATCCCTACCAGCCTGCAGTCCTGGCTGCTTCCAAGCAGGAGGCAAGCACGAGGAGCGGCAGGACGAGCAT GGCTACATCTCCCGGTGCTTCACGCGGAAATACACCACCTTCGAGTCGCGGGCCCAGCTTGGGGGCCCAGAAGCTGCAAAATCCGATGAG ACTGCCGCCAAGTAAAGCCTTAGCCCGGATGCCCACCCCTGCTGCCGCCACTGGCTGTGCCTCCCCCGCCACCTGTGTGTTCTTTTGATA CATTTATCTTCTGTTTTTCTCAAATAAAGTTCAAAGCAACCACCTGTAGCCGCACCCAGCAGCCTTCGCTAACCCCTCTGTCTACTATTA AGGCCTTTGCCACTCAGTCGGGCTCCCAGGACCTGAAGGCCCTCAATACCAGCTACCAGTCCCAGCTCATCAAACCCAGCCGCATGCGCA AGTACCCCAACCGGCCCAGCAAGACGCCCCCCCACGAACGCCCTTACGCTTGCCCAGTGGAGTCCTGTGATCGCCGCTTCTCCCGCTCCG ACGAGCTCACCCGCCACATCCGCATCCACACAGGCCAGAAGCCCTTCCAGTGCCGCATCTGCATGCGCAACTTCAGCCGCAGCGACCACC TCACCACCCACATCCGCACCCACACAGGCGAAAAGCCCTTCGCCTGCGACATCTGTGGAAGAAAGTTTGCCAGGAGCGATGAACGCAAGA GGCATACCAAGATCCACTTGCGGCAGAAGGACAAGAAAGCAGACAAAAGTGTTGTGGCCTCTTCGGCCACCTCCTCTCTCTCTTCCTACC CGTCCCCGGTTGCTACCTCTTACCCGTCCCCGGTTACTACCTCTTATCCATCCCCGGCCACCACCTCATACCCATCCCCTGTGCCCACCT CCTTCTCCTCTCCCGGCTCCTCGACCTACCCATCCCCTGTGCACAGTGGCTTCCCCTCCCCGTCGGTGGCCACCACGTACTCCTCTGTTC CCCCTGCTTTCCCGGCCCAGGTCAGCAGCTTCCCTTCCTCAGCTGTCACCAACTCCTTCAGCGCCTCCACAGGGCTTTCGGACATGACAG CAACCTTTTCTCCCAGGACAATTGAAATTTGCTAAAGGGAAAGGGGAAAGAAAGGGAAAAGGGAGAAAAAGAAACACAAGAGACTTAAAG GACAGGAGGAGGAGATGGCCATAGGAGAGGAGGGTTCCTCTTAGGTCAGATGGAGGTTCTCAGAGCCAAGTCCTCCCTCTCTACTGGAGT GGAAGGTCTATTGGCCAACAATCCTTTCTGCCCACTTCCCCTTCCCCAATTACTATTCCCTTTGACTTCAGCTGCCTGAAACAGCCATGT CCAAGTTCTTCACCTCTATCCAAAGAACTTGATTTGCATGGATTTTGGATAAATCATTTCAGTATCATCTCCATCATATGCCTGACCCCT TGCTCCCTTCAATGCTAGAAAATCGAGTTGGCAAAATGGGGTTTGGGCCCCTCAGAGCCCTGCCCTGCACCCTTGTACAGTGTCTGTGCC ATGGATTTCGTTTTTCTTGGGGTACTCTTGATGTGAAGATAATTTGCATATTCTATTGTATTATTTGGAGTTAGGTCCTCACTTGGGGGA AAAAAAAAAAAGAAAAGCCAAGCAAACCAATGGTGATCCTCTATTTTGTGATGATGCTGTGACAATAAGTTTGAACCTTTTTTTTTGAAA CAGCAGTCCCAGTATTCTCAGAGCATGTGTCAGAGTGTTGTTCCGTTAACCTTTTTGTAAATACTGCTTGACCGTACTCTCACATGTGGC AAAATATGGTTTGGTTTTTCTTTTTTTTTTTTTTTGAAAGTGTTTTTTCTTCGTCCTTTTGGTTTAAAAAGTTTCACGTCTTGGTGCCTT TTGTGTGATGCGCCTTGCTGATGGCTTGACATGTGCAATTGTGAGGGACATGCTCACCTCTAGCCTTAAGGGGGGCAGGGAGTGATGATT TGGGGGAGGCTTTGGGAGCAAAATAAGGAAGAGGGCTGAGCTGAGCTTCGGTTCTCCAGAATGTAAGAAAACAAAATCTAAAACAAAATC TGAACTCTCAAAAGTCTATTTTTTTAACTGAAAATGTAAATTTATAAATATATTCAGGAGTTGGAATGTTGTAGTTACCTACTGAGTAGG CGGCGATTTTTGTATGTTATGAACATGCAGTTCATTATTTTGTGGTTCTATTTTACTTTGTACTTGTGTTTGCTTAAACAAAGTGACTGT TTGGCTTATAAACACATTGAATGCGCTTTATTGCCCATGGGATATGTGGTGTATATCCTTCCAAAAAATTAAAACGAAAATAAAGTAGCT >37933_37933_2_HSPB1-EGR1_HSPB1_chr7_75933420_ENST00000429938_EGR1_chr5_137802972_ENST00000239938_length(amino acids)=298AA_BP=33 MLPPLAVPPPPPVCSFDTFIFCFSQIKFKATTCSRTQQPSLTPLSTIKAFATQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHE RPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKK ADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSSTYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for HSPB1-EGR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | HSPB1 | chr7:75933420 | chr5:137802972 | ENST00000248553 | + | 1 | 3 | 70_205 | 0 | 206.0 | TGFB1I1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HSPB1-EGR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for HSPB1-EGR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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