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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HTATIP2-ARHGAP27 (FusionGDB2 ID:38043)

Fusion Gene Summary for HTATIP2-ARHGAP27

check button Fusion gene summary
Fusion gene informationFusion gene name: HTATIP2-ARHGAP27
Fusion gene ID: 38043
HgeneTgene
Gene symbol

HTATIP2

ARHGAP27

Gene ID

10553

201176

Gene nameHIV-1 Tat interactive protein 2Rho GTPase activating protein 27
SynonymsCC3|SDR44U1|TIP30CAMGAP1|PP905|SH3D20|SH3P20
Cytomap

11p15.1

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionoxidoreductase HTATIP230 kDa HIV-1 TAT-interacting proteinHIV-1 TAT-interactive protein 2HIV-1 Tat interactive protein 2, 30kDaTat-interacting protein (30kD)short chain dehydrogenase/reductase family 44U, member 1rho GTPase-activating protein 27CIN85-associated multi-domain-containing Rho GTPase-activating protein 1SH3 domain containing 20SH3 domain-containing protein 20rho-type GTPase-activating protein 27
Modification date2020031320200320
UniProtAcc

Q9BUP3

Q6ZUM4

Ensembl transtripts involved in fusion geneENST00000532081, ENST00000419348, 
ENST00000421577, ENST00000443524, 
ENST00000451739, ENST00000530266, 
ENST00000531058, ENST00000532505, 
ENST00000290470, ENST00000376922, 
ENST00000428638, ENST00000442348, 
ENST00000455881, ENST00000528273, 
ENST00000528384, ENST00000532038, 
ENST00000532891, ENST00000582826, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 3=75
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/75*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HTATIP2 [Title/Abstract] AND ARHGAP27 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHTATIP2(20389201)-ARHGAP27(43493846), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHTATIP2

GO:0043068

positive regulation of programmed cell death

10698937

HgeneHTATIP2

GO:0045765

regulation of angiogenesis

11313954

HgeneHTATIP2

GO:0045944

positive regulation of transcription by RNA polymerase II

10698937

HgeneHTATIP2

GO:0046777

protein autophosphorylation

10698937

HgeneHTATIP2

GO:0051170

import into nucleus

15282309


check buttonFusion gene breakpoints across HTATIP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ARHGAP27 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG032668HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-


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Fusion Gene ORF analysis for HTATIP2-ARHGAP27

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000532081ENST00000290470HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
5CDS-intronENST00000532081ENST00000376922HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
5CDS-intronENST00000532081ENST00000428638HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
5CDS-intronENST00000532081ENST00000442348HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
5CDS-intronENST00000532081ENST00000455881HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
5CDS-intronENST00000532081ENST00000528273HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
5CDS-intronENST00000532081ENST00000528384HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
5CDS-intronENST00000532081ENST00000532038HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
5CDS-intronENST00000532081ENST00000532891HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
5CDS-intronENST00000532081ENST00000582826HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000419348ENST00000290470HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000419348ENST00000376922HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000419348ENST00000428638HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000419348ENST00000442348HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000419348ENST00000455881HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000419348ENST00000528273HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000419348ENST00000528384HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000419348ENST00000532038HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000419348ENST00000532891HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000419348ENST00000582826HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000421577ENST00000290470HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000421577ENST00000376922HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000421577ENST00000428638HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000421577ENST00000442348HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000421577ENST00000455881HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000421577ENST00000528273HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000421577ENST00000528384HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000421577ENST00000532038HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000421577ENST00000532891HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000421577ENST00000582826HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000443524ENST00000290470HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000443524ENST00000376922HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000443524ENST00000428638HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000443524ENST00000442348HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000443524ENST00000455881HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000443524ENST00000528273HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000443524ENST00000528384HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000443524ENST00000532038HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000443524ENST00000532891HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000443524ENST00000582826HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000451739ENST00000290470HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000451739ENST00000376922HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000451739ENST00000428638HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000451739ENST00000442348HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000451739ENST00000455881HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000451739ENST00000528273HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000451739ENST00000528384HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000451739ENST00000532038HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000451739ENST00000532891HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000451739ENST00000582826HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000530266ENST00000290470HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000530266ENST00000376922HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000530266ENST00000428638HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000530266ENST00000442348HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000530266ENST00000455881HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000530266ENST00000528273HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000530266ENST00000528384HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000530266ENST00000532038HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000530266ENST00000532891HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000530266ENST00000582826HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000531058ENST00000290470HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000531058ENST00000376922HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000531058ENST00000428638HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000531058ENST00000442348HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000531058ENST00000455881HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000531058ENST00000528273HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000531058ENST00000528384HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000531058ENST00000532038HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000531058ENST00000532891HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000531058ENST00000582826HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000532505ENST00000290470HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000532505ENST00000376922HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000532505ENST00000428638HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000532505ENST00000442348HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000532505ENST00000455881HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000532505ENST00000528273HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000532505ENST00000528384HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000532505ENST00000532038HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000532505ENST00000532891HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-
intron-intronENST00000532505ENST00000582826HTATIP2chr11

20389201

+ARHGAP27chr17

43493846

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HTATIP2-ARHGAP27


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HTATIP2-ARHGAP27


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:20389201/:43493846)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HTATIP2

Q9BUP3

ARHGAP27

Q6ZUM4

FUNCTION: Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. {ECO:0000269|PubMed:10611237, ECO:0000269|PubMed:11313954, ECO:0000269|PubMed:15282309, ECO:0000269|PubMed:9174052}.FUNCTION: Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HTATIP2-ARHGAP27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HTATIP2-ARHGAP27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HTATIP2-ARHGAP27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HTATIP2-ARHGAP27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource