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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HTN3-STATH (FusionGDB2 ID:38057)

Fusion Gene Summary for HTN3-STATH

check button Fusion gene summary
Fusion gene informationFusion gene name: HTN3-STATH
Fusion gene ID: 38057
HgeneTgene
Gene symbol

HTN3

STATH

Gene ID

3347

6779

Gene namehistatin 3statherin
SynonymsHIS2|HTN2|HTN5|PBSTR
Cytomap

4q13.3

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionhistatin-3basic histidine-rich proteinhistatin-4histatin-5histatin-6histatin-7histatin-8histatin-9histidine-rich protein 3statherin
Modification date2020032020200313
UniProtAcc

P15516

STMN4

Ensembl transtripts involved in fusion geneENST00000381057, ENST00000526767, 
ENST00000530128, 		ENST00000246895, 
ENST00000381060, 
Fusion gene scores* DoF score5 X 10 X 3=1506 X 14 X 3=252
# samples 88
** MAII scorelog2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HTN3 [Title/Abstract] AND STATH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHTN3(70898970)-STATH(70867906), # samples:5
HTN3(70894233)-STATH(70864142), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HTN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STATH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315325HTN3chr4

70894233

+STATHchr4

70864142

+
ChimerDB4Non-CancerERR315382HTN3chr4

70898970

+STATHchr4

70867906

+
ChimerDB4Non-CancerERR315418HTN3chr4

70894233

+STATHchr4

70864140

+
ChimerDB4Non-CancerERR315418HTN3chr4

70894233

+STATHchr4

70864142

+
ChimerDB4Non-CancerERR315418HTN3chr4

70898970

+STATHchr4

70867906

+
ChimerDB4Non-CancerERR315420HTN3chr4

70894233

+STATHchr4

70864142

+
ChimerDB4Non-CancerERR315420HTN3chr4

70896471

+STATHchr4

70864169

+
ChimerDB4Non-CancerERR315420HTN3chr4

70898970

+STATHchr4

70867906

+
ChimerDB4Non-CancerERR315420HTN3chr4

70921319

+STATHchr4

70867906

+
ChimerDB4Non-CancerERR315449HTN3chr4

70894233

+STATHchr4

70864140

+
ChimerDB4Non-CancerERR315449HTN3chr4

70894233

+STATHchr4

70864142

+
ChimerDB4Non-CancerERR315449HTN3chr4

70898970

+STATHchr4

70867906

+
ChimerDB4Non-CancerERR315449HTN3chr4

70924483

+STATHchr4

70868093

+
ChimerDB4Non-CancerERR315459HTN3chr4

70894233

+STATHchr4

70864140

+
ChimerDB4Non-CancerERR315459HTN3chr4

70894233

+STATHchr4

70864142

+
ChimerDB4Non-CancerERR315459HTN3chr4

70898970

+STATHchr4

70867906

+
ChimerDB4Non-CancerERR315459HTN3chr4

70918817

+STATHchr4

70864179

+


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Fusion Gene ORF analysis for HTN3-STATH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000381057ENST00000246895HTN3chr4

70898970

+STATHchr4

70867906

+
3UTR-3UTRENST00000381057ENST00000381060HTN3chr4

70898970

+STATHchr4

70867906

+
3UTR-3UTRENST00000526767ENST00000246895HTN3chr4

70898970

+STATHchr4

70867906

+
3UTR-3UTRENST00000526767ENST00000381060HTN3chr4

70898970

+STATHchr4

70867906

+
3UTR-3UTRENST00000530128ENST00000246895HTN3chr4

70898970

+STATHchr4

70867906

+
3UTR-3UTRENST00000530128ENST00000381060HTN3chr4

70898970

+STATHchr4

70867906

+
5UTR-5UTRENST00000381057ENST00000246895HTN3chr4

70894233

+STATHchr4

70864140

+
5UTR-5UTRENST00000381057ENST00000246895HTN3chr4

70894233

+STATHchr4

70864142

+
5UTR-5UTRENST00000381057ENST00000381060HTN3chr4

70894233

+STATHchr4

70864140

+
5UTR-5UTRENST00000381057ENST00000381060HTN3chr4

70894233

+STATHchr4

70864142

+
5UTR-5UTRENST00000526767ENST00000246895HTN3chr4

70894233

+STATHchr4

70864140

+
5UTR-5UTRENST00000526767ENST00000246895HTN3chr4

70894233

+STATHchr4

70864142

+
5UTR-5UTRENST00000526767ENST00000381060HTN3chr4

70894233

+STATHchr4

70864140

+
5UTR-5UTRENST00000526767ENST00000381060HTN3chr4

70894233

+STATHchr4

70864142

+
5UTR-5UTRENST00000530128ENST00000246895HTN3chr4

70894233

+STATHchr4

70864140

+
5UTR-5UTRENST00000530128ENST00000246895HTN3chr4

70894233

+STATHchr4

70864142

+
5UTR-5UTRENST00000530128ENST00000381060HTN3chr4

70894233

+STATHchr4

70864140

+
5UTR-5UTRENST00000530128ENST00000381060HTN3chr4

70894233

+STATHchr4

70864142

+
In-frameENST00000381057ENST00000246895HTN3chr4

70896471

+STATHchr4

70864169

+
In-frameENST00000381057ENST00000381060HTN3chr4

70896471

+STATHchr4

70864169

+
In-frameENST00000526767ENST00000246895HTN3chr4

70896471

+STATHchr4

70864169

+
In-frameENST00000526767ENST00000381060HTN3chr4

70896471

+STATHchr4

70864169

+
In-frameENST00000530128ENST00000246895HTN3chr4

70896471

+STATHchr4

70864169

+
In-frameENST00000530128ENST00000381060HTN3chr4

70896471

+STATHchr4

70864169

+
intron-3CDSENST00000381057ENST00000246895HTN3chr4

70918817

+STATHchr4

70864179

+
intron-3CDSENST00000381057ENST00000381060HTN3chr4

70918817

+STATHchr4

70864179

+
intron-3CDSENST00000526767ENST00000246895HTN3chr4

70918817

+STATHchr4

70864179

+
intron-3CDSENST00000526767ENST00000381060HTN3chr4

70918817

+STATHchr4

70864179

+
intron-3CDSENST00000530128ENST00000246895HTN3chr4

70918817

+STATHchr4

70864179

+
intron-3CDSENST00000530128ENST00000381060HTN3chr4

70918817

+STATHchr4

70864179

+
intron-3UTRENST00000381057ENST00000246895HTN3chr4

70921319

+STATHchr4

70867906

+
intron-3UTRENST00000381057ENST00000246895HTN3chr4

70924483

+STATHchr4

70868093

+
intron-3UTRENST00000381057ENST00000381060HTN3chr4

70921319

+STATHchr4

70867906

+
intron-3UTRENST00000381057ENST00000381060HTN3chr4

70924483

+STATHchr4

70868093

+
intron-3UTRENST00000526767ENST00000246895HTN3chr4

70921319

+STATHchr4

70867906

+
intron-3UTRENST00000526767ENST00000246895HTN3chr4

70924483

+STATHchr4

70868093

+
intron-3UTRENST00000526767ENST00000381060HTN3chr4

70921319

+STATHchr4

70867906

+
intron-3UTRENST00000526767ENST00000381060HTN3chr4

70924483

+STATHchr4

70868093

+
intron-3UTRENST00000530128ENST00000246895HTN3chr4

70921319

+STATHchr4

70867906

+
intron-3UTRENST00000530128ENST00000246895HTN3chr4

70924483

+STATHchr4

70868093

+
intron-3UTRENST00000530128ENST00000381060HTN3chr4

70921319

+STATHchr4

70867906

+
intron-3UTRENST00000530128ENST00000381060HTN3chr4

70924483

+STATHchr4

70868093

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HTN3-STATH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HTN3chr470894233+STATHchr470864139+0.93749220.06250777
HTN3chr470898970+STATHchr470867905+0.166727840.8332722
HTN3chr470894233+STATHchr470864139+0.93749220.06250777
HTN3chr470898970+STATHchr470867905+0.166727840.8332722

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HTN3-STATH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:70898970/chr4:70867906)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HTN3

P15516

STATH

STMN4

FUNCTION: Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9. {ECO:0000269|PubMed:11179305, ECO:0000269|PubMed:8945538}.189

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTATHchr4:70896471chr4:70864169ENST000002468950620_250119.33333333333333RegionNote=Hydroxyapatite-binding%3B inhibits crystal growth
TgeneSTATHchr4:70896471chr4:70864169ENST000002468950638_620119.33333333333333RegionNote=Hydrophobic%3B inhibits precipitation of calcium phosphate salts
TgeneSTATHchr4:70896471chr4:70864169ENST000003810600520_250122.0RegionNote=Hydroxyapatite-binding%3B inhibits crystal growth
TgeneSTATHchr4:70896471chr4:70864169ENST000003810600538_620122.0RegionNote=Hydrophobic%3B inhibits precipitation of calcium phosphate salts

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HTN3-STATH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HTN3-STATH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HTN3-STATH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HTN3-STATH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource