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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HUNK-MRAP (FusionGDB2 ID:38099)

Fusion Gene Summary for HUNK-MRAP

check button Fusion gene summary
Fusion gene informationFusion gene name: HUNK-MRAP
Fusion gene ID: 38099
HgeneTgene
Gene symbol

HUNK

MRAP

Gene ID

30811

56246

Gene namehormonally up-regulated Neu-associated kinasemelanocortin 2 receptor accessory protein
Synonyms-B27|C21orf61|FALP|FGD2|GCCD2
Cytomap

21q22.11

21q22.11

Type of geneprotein-codingprotein-coding
Descriptionhormonally up-regulated neu tumor-associated kinaseB19hormonally upregulated Neu-associated kinasehormonally upregulated neu tumor-associated kinaseserine/threonine protein kinase MAK-Vmelanocortin-2 receptor accessory proteinfat cell-specific low molecular weight proteinfat tissue-specific low MW protein
Modification date2020031320200326
UniProtAcc

P57058

Q8TCY5

Ensembl transtripts involved in fusion geneENST00000270112, ENST00000465574, 
ENST00000303645, ENST00000399784, 
ENST00000497833, ENST00000339944, 
ENST00000399786, 
Fusion gene scores* DoF score8 X 8 X 5=3203 X 5 X 2=30
# samples 95
** MAII scorelog2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HUNK [Title/Abstract] AND MRAP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHUNK(33297072)-MRAP(33678951), # samples:1
HUNK(33297072)-MRAP(33678950), # samples:1
Anticipated loss of major functional domain due to fusion event.HUNK-MRAP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HUNK-MRAP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HUNK-MRAP seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMRAP

GO:0072659

protein localization to plasma membrane

19329486

TgeneMRAP

GO:0106071

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

19329486

TgeneMRAP

GO:0106072

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

19329486

TgeneMRAP

GO:1903077

negative regulation of protein localization to plasma membrane

19329486


check buttonFusion gene breakpoints across HUNK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MRAP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A1J2-01AHUNKchr21

33297072

+MRAPchr21

33678951

+
ChimerDB4BRCATCGA-EW-A1J2HUNKchr21

33297072

+MRAPchr21

33678950

+


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Fusion Gene ORF analysis for HUNK-MRAP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000270112ENST00000303645HUNKchr21

33297072

+MRAPchr21

33678951

+
5CDS-3UTRENST00000270112ENST00000303645HUNKchr21

33297072

+MRAPchr21

33678950

+
5CDS-3UTRENST00000270112ENST00000399784HUNKchr21

33297072

+MRAPchr21

33678951

+
5CDS-3UTRENST00000270112ENST00000399784HUNKchr21

33297072

+MRAPchr21

33678950

+
5CDS-3UTRENST00000270112ENST00000497833HUNKchr21

33297072

+MRAPchr21

33678951

+
5CDS-3UTRENST00000270112ENST00000497833HUNKchr21

33297072

+MRAPchr21

33678950

+
Frame-shiftENST00000270112ENST00000339944HUNKchr21

33297072

+MRAPchr21

33678951

+
Frame-shiftENST00000270112ENST00000339944HUNKchr21

33297072

+MRAPchr21

33678950

+
Frame-shiftENST00000270112ENST00000399786HUNKchr21

33297072

+MRAPchr21

33678951

+
Frame-shiftENST00000270112ENST00000399786HUNKchr21

33297072

+MRAPchr21

33678950

+
intron-3CDSENST00000465574ENST00000339944HUNKchr21

33297072

+MRAPchr21

33678951

+
intron-3CDSENST00000465574ENST00000339944HUNKchr21

33297072

+MRAPchr21

33678950

+
intron-3CDSENST00000465574ENST00000399786HUNKchr21

33297072

+MRAPchr21

33678951

+
intron-3CDSENST00000465574ENST00000399786HUNKchr21

33297072

+MRAPchr21

33678950

+
intron-3UTRENST00000465574ENST00000303645HUNKchr21

33297072

+MRAPchr21

33678951

+
intron-3UTRENST00000465574ENST00000303645HUNKchr21

33297072

+MRAPchr21

33678950

+
intron-3UTRENST00000465574ENST00000399784HUNKchr21

33297072

+MRAPchr21

33678951

+
intron-3UTRENST00000465574ENST00000399784HUNKchr21

33297072

+MRAPchr21

33678950

+
intron-3UTRENST00000465574ENST00000497833HUNKchr21

33297072

+MRAPchr21

33678951

+
intron-3UTRENST00000465574ENST00000497833HUNKchr21

33297072

+MRAPchr21

33678950

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HUNK-MRAP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HUNKchr2133297072+MRAPchr2133678950+2.39E-081
HUNKchr2133297072+MRAPchr2133678950+2.39E-081
HUNKchr2133297072+MRAPchr2133678950+2.39E-081
HUNKchr2133297072+MRAPchr2133678950+2.39E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HUNK-MRAP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:33297072/:33678951)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HUNK

P57058

MRAP

Q8TCY5

FUNCTION: Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. {ECO:0000269|PubMed:15654338, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HUNK-MRAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HUNK-MRAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HUNK-MRAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HUNK-MRAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource