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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HUWE1-PHF8 (FusionGDB2 ID:38113)

Fusion Gene Summary for HUWE1-PHF8

check button Fusion gene summary
Fusion gene informationFusion gene name: HUWE1-PHF8
Fusion gene ID: 38113
HgeneTgene
Gene symbol

HUWE1

PHF8

Gene ID

10075

23133

Gene nameHECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1PHD finger protein 8
SynonymsARF-BP1|HECTH9|HSPC272|Ib772|LASU1|MRXST|MULE|URE-B1|UREB1JHDM1F|KDM7B|MRXSSD|ZNF422
Cytomap

Xp11.22

Xp11.22

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase HUWE1ARF-binding protein 1BJ-HCC-24 tumor antigenHECT domain protein LASU1HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligaseHECT-type E3 ubiquitin transferase HUWE1Mcl-1 ubiquitin ligase E3URE-binding prohistone lysine demethylase PHF8jumonji C domain-containing histone demethylase 1F
Modification date2020031320200313
UniProtAcc

Q7Z6Z7

.
Ensembl transtripts involved in fusion geneENST00000218328, ENST00000262854, 
ENST00000342160, ENST00000474288, 
ENST00000462182, ENST00000322659, 
ENST00000338154, ENST00000338946, 
ENST00000357988, 
Fusion gene scores* DoF score17 X 22 X 7=26183 X 4 X 4=48
# samples 224
** MAII scorelog2(22/2618*10)=-3.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HUWE1 [Title/Abstract] AND PHF8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHUWE1(53634484)-PHF8(53970676), # samples:2
Anticipated loss of major functional domain due to fusion event.HUWE1-PHF8 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
HUWE1-PHF8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HUWE1-PHF8 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
HUWE1-PHF8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
HUWE1-PHF8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHUWE1

GO:0000209

protein polyubiquitination

15989957

HgeneHUWE1

GO:0006513

protein monoubiquitination

19713937

HgeneHUWE1

GO:0016574

histone ubiquitination

15767685

HgeneHUWE1

GO:0031398

positive regulation of protein ubiquitination

20534529

HgeneHUWE1

GO:0098779

positive regulation of mitophagy in response to mitochondrial depolarization

30217973

TgenePHF8

GO:0033169

histone H3-K9 demethylation

20023638|20208542|20346720|20622853|20622854

TgenePHF8

GO:0035574

histone H4-K20 demethylation

20622853|20622854

TgenePHF8

GO:0045893

positive regulation of transcription, DNA-templated

20622853

TgenePHF8

GO:0045943

positive regulation of transcription by RNA polymerase I

20208542

TgenePHF8

GO:0061188

negative regulation of chromatin silencing at rDNA

20208542

TgenePHF8

GO:0070544

histone H3-K36 demethylation

20208542|20622853

TgenePHF8

GO:0071557

histone H3-K27 demethylation

20622853|20622854


check buttonFusion gene breakpoints across HUWE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PHF8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A18T-01AHUWE1chrX

53634484

-PHF8chrX

53970676

-
ChimerDB4UCECTCGA-AJ-A6NU-01AHUWE1chrX

53635813

-PHF8chrX

54049276

-


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Fusion Gene ORF analysis for HUWE1-PHF8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000218328ENST00000462182HUWE1chrX

53634484

-PHF8chrX

53970676

-
5CDS-intronENST00000218328ENST00000462182HUWE1chrX

53635813

-PHF8chrX

54049276

-
5CDS-intronENST00000262854ENST00000462182HUWE1chrX

53634484

-PHF8chrX

53970676

-
5CDS-intronENST00000262854ENST00000462182HUWE1chrX

53635813

-PHF8chrX

54049276

-
5CDS-intronENST00000342160ENST00000462182HUWE1chrX

53634484

-PHF8chrX

53970676

-
5CDS-intronENST00000342160ENST00000462182HUWE1chrX

53635813

-PHF8chrX

54049276

-
Frame-shiftENST00000218328ENST00000322659HUWE1chrX

53634484

-PHF8chrX

53970676

-
Frame-shiftENST00000218328ENST00000322659HUWE1chrX

53635813

-PHF8chrX

54049276

-
Frame-shiftENST00000218328ENST00000338154HUWE1chrX

53634484

-PHF8chrX

53970676

-
Frame-shiftENST00000218328ENST00000338154HUWE1chrX

53635813

-PHF8chrX

54049276

-
Frame-shiftENST00000218328ENST00000338946HUWE1chrX

53634484

-PHF8chrX

53970676

-
Frame-shiftENST00000218328ENST00000338946HUWE1chrX

53635813

-PHF8chrX

54049276

-
Frame-shiftENST00000218328ENST00000357988HUWE1chrX

53634484

-PHF8chrX

53970676

-
Frame-shiftENST00000218328ENST00000357988HUWE1chrX

53635813

-PHF8chrX

54049276

-
Frame-shiftENST00000262854ENST00000322659HUWE1chrX

53634484

-PHF8chrX

53970676

-
Frame-shiftENST00000262854ENST00000322659HUWE1chrX

53635813

-PHF8chrX

54049276

-
Frame-shiftENST00000262854ENST00000338154HUWE1chrX

53634484

-PHF8chrX

53970676

-
Frame-shiftENST00000262854ENST00000338154HUWE1chrX

53635813

-PHF8chrX

54049276

-
Frame-shiftENST00000262854ENST00000338946HUWE1chrX

53634484

-PHF8chrX

53970676

-
Frame-shiftENST00000262854ENST00000338946HUWE1chrX

53635813

-PHF8chrX

54049276

-
Frame-shiftENST00000262854ENST00000357988HUWE1chrX

53634484

-PHF8chrX

53970676

-
Frame-shiftENST00000262854ENST00000357988HUWE1chrX

53635813

-PHF8chrX

54049276

-
Frame-shiftENST00000342160ENST00000322659HUWE1chrX

53634484

-PHF8chrX

53970676

-
Frame-shiftENST00000342160ENST00000338154HUWE1chrX

53634484

-PHF8chrX

53970676

-
Frame-shiftENST00000342160ENST00000338946HUWE1chrX

53634484

-PHF8chrX

53970676

-
Frame-shiftENST00000342160ENST00000357988HUWE1chrX

53634484

-PHF8chrX

53970676

-
In-frameENST00000342160ENST00000322659HUWE1chrX

53635813

-PHF8chrX

54049276

-
In-frameENST00000342160ENST00000338154HUWE1chrX

53635813

-PHF8chrX

54049276

-
In-frameENST00000342160ENST00000338946HUWE1chrX

53635813

-PHF8chrX

54049276

-
In-frameENST00000342160ENST00000357988HUWE1chrX

53635813

-PHF8chrX

54049276

-
intron-3CDSENST00000474288ENST00000322659HUWE1chrX

53634484

-PHF8chrX

53970676

-
intron-3CDSENST00000474288ENST00000322659HUWE1chrX

53635813

-PHF8chrX

54049276

-
intron-3CDSENST00000474288ENST00000338154HUWE1chrX

53634484

-PHF8chrX

53970676

-
intron-3CDSENST00000474288ENST00000338154HUWE1chrX

53635813

-PHF8chrX

54049276

-
intron-3CDSENST00000474288ENST00000338946HUWE1chrX

53634484

-PHF8chrX

53970676

-
intron-3CDSENST00000474288ENST00000338946HUWE1chrX

53635813

-PHF8chrX

54049276

-
intron-3CDSENST00000474288ENST00000357988HUWE1chrX

53634484

-PHF8chrX

53970676

-
intron-3CDSENST00000474288ENST00000357988HUWE1chrX

53635813

-PHF8chrX

54049276

-
intron-intronENST00000474288ENST00000462182HUWE1chrX

53634484

-PHF8chrX

53970676

-
intron-intronENST00000474288ENST00000462182HUWE1chrX

53635813

-PHF8chrX

54049276

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000342160HUWE1chrX53635813-ENST00000338154PHF8chrX54049276-82362777248457531089
ENST00000342160HUWE1chrX53635813-ENST00000357988PHF8chrX54049276-82362777248457531089
ENST00000342160HUWE1chrX53635813-ENST00000338946PHF8chrX54049276-68252777248455251013
ENST00000342160HUWE1chrX53635813-ENST00000322659PHF8chrX54049276-5424277724845315943

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000342160ENST00000338154HUWE1chrX53635813-PHF8chrX54049276-0.0085921480.9914078
ENST00000342160ENST00000357988HUWE1chrX53635813-PHF8chrX54049276-0.0085921480.9914078
ENST00000342160ENST00000338946HUWE1chrX53635813-PHF8chrX54049276-0.0163044670.9836955
ENST00000342160ENST00000322659HUWE1chrX53635813-PHF8chrX54049276-0.0115684720.9884316

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Fusion Genomic Features for HUWE1-PHF8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HUWE1-PHF8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:53634484/chrX:53970676)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HUWE1

Q7Z6Z7

.
FUNCTION: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15989957, PubMed:19713937, PubMed:15567145, PubMed:15767685, PubMed:18488021, PubMed:17567951, PubMed:19037095, PubMed:20534529). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). {ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePHF8chrX:53635813chrX:54049276ENST00000338154122769_807321025.0Compositional biasNote=Ser-rich
TgenePHF8chrX:53635813chrX:54049276ENST00000338946122769_80732949.0Compositional biasNote=Ser-rich
TgenePHF8chrX:53635813chrX:54049276ENST00000357988122769_807681061.0Compositional biasNote=Ser-rich
TgenePHF8chrX:53635813chrX:54049276ENST00000338154122231_387321025.0DomainJmjC
TgenePHF8chrX:53635813chrX:54049276ENST00000338946122231_38732949.0DomainJmjC
TgenePHF8chrX:53635813chrX:54049276ENST00000357988122231_387681061.0DomainJmjC
TgenePHF8chrX:53635813chrX:54049276ENST00000338154122101_115321025.0RegionNote=Linker
TgenePHF8chrX:53635813chrX:54049276ENST00000338946122101_11532949.0RegionNote=Linker
TgenePHF8chrX:53635813chrX:54049276ENST00000357988122101_115681061.0RegionNote=Linker
TgenePHF8chrX:53635813chrX:54049276ENST0000033815412241_92321025.0Zinc fingerPHD-type
TgenePHF8chrX:53635813chrX:54049276ENST0000033894612241_9232949.0Zinc fingerPHD-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHUWE1chrX:53635813chrX:54049276ENST00000262854-24842295_24697734375.0Compositional biasNote=Glu-rich
HgeneHUWE1chrX:53635813chrX:54049276ENST00000262854-24842427_24907734375.0Compositional biasNote=Asp-rich
HgeneHUWE1chrX:53635813chrX:54049276ENST00000262854-24843483_35507734375.0Compositional biasNote=Thr-rich
HgeneHUWE1chrX:53635813chrX:54049276ENST00000342160-23832295_24697734375.0Compositional biasNote=Glu-rich
HgeneHUWE1chrX:53635813chrX:54049276ENST00000342160-23832427_24907734375.0Compositional biasNote=Asp-rich
HgeneHUWE1chrX:53635813chrX:54049276ENST00000342160-23833483_35507734375.0Compositional biasNote=Thr-rich
HgeneHUWE1chrX:53635813chrX:54049276ENST00000262854-24841316_13557734375.0DomainUBA
HgeneHUWE1chrX:53635813chrX:54049276ENST00000262854-24841370_13897734375.0DomainUIM
HgeneHUWE1chrX:53635813chrX:54049276ENST00000262854-24841603_16807734375.0DomainWWE
HgeneHUWE1chrX:53635813chrX:54049276ENST00000262854-24844038_43747734375.0DomainHECT
HgeneHUWE1chrX:53635813chrX:54049276ENST00000342160-23831316_13557734375.0DomainUBA
HgeneHUWE1chrX:53635813chrX:54049276ENST00000342160-23831370_13897734375.0DomainUIM
HgeneHUWE1chrX:53635813chrX:54049276ENST00000342160-23831603_16807734375.0DomainWWE
HgeneHUWE1chrX:53635813chrX:54049276ENST00000342160-23834038_43747734375.0DomainHECT
TgenePHF8chrX:53635813chrX:54049276ENST0000035798812241_92681061.0Zinc fingerPHD-type


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Fusion Gene Sequence for HUWE1-PHF8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>38113_38113_1_HUWE1-PHF8_HUWE1_chrX_53635813_ENST00000342160_PHF8_chrX_54049276_ENST00000322659_length(transcript)=5424nt_BP=2777nt
TCCGCCCCTCACTGCTTCGTTAGGTTGTGCGTCATTTGCTTTTCGCTTCGCGTAGGGTGAAGCTGTAGCTACTTCGGCTTTGGTGGGAGG
GAGGAGGGGTCTGGAAAGGGCTGGGCTCAGGCTTTTCCCGTCCGGTAGAGGTTCTCGCGGGATCGCGCGGAGGCGGCGGTGGCTCGGTTA
CTGACTGCAGTAGCCGCGGAGGCGGCGGCAAGGTCTTCGGCTCGTGCCGTTCTAAGCCGGAGAATTCTCGCGGGAGCAGGGTTACGTCCT
CGTGGGATTCGTTGGCGGTGGCTGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTAGTGATCCAGAGAAACCAGCAGGCCAACTTGGTCA
GGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTATGATTGGCTGTGATTTTAGATCGTAAAGCTGAAAA
TTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCTGCAGACTGCAGAGCCTTAATAGACAAACTCAAAG
TTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATTGGAAAGTGCGAGTTATATCACTGGGTGGACCTGT
TGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCATGGATGCTCGTATGTGATAGGCCAGAAAGAGAGC
AACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTACAGCTTTTCCCGGCATCTGTACAGTTCCATAGAGC
ATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAATCTCCTATATGTATTTAGCAAAAGATCAAACTACA
TCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTGGCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTG
GACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACTACACTACACTTTGAATTCTATGCAGATCCTGGGG
CCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATAGAGCAACTTGACAAGATTTCAGAAAGCCCTTCTG
AAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTGTTATTTACACACATACGACTGGCCCATGGCTTTT
CTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATATTAGTGTATTCCAATGCCTTGCAGGAATCAGCAA
ACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACGGATAAGCAGCTTATGGAGATTAAAGCAGCTTCTT
TACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATTATTGACTGTACTGGAACTGCCTCCTACCATGGAT
TTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGATCCATACCCTCACCAGTTTGCCACTGCTCTCTTCT
CTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGTGGAATGATGGAAGCCTTATTGAAGGTCATAAAGT
TTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTTGACCTTATCACCAACCTGGATATGGCAGCTTTTC
AATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTGTGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAA
AGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGATGGAGTCCAGTGTATTCCACAACGAGCAGCACTTC
TGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGATGGCATACGACATGTGATGGATGGTTCTCTGCCTA
CCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTCCTAGCTACTGAAGTGGTGACTGTGTTTGTATTTC
AAGAACCATCACTGCTCTCCTCACTCCAGGACAATGGATTGACAGATGTCATGCTGCATGCACTGCTTATCAAAGATGTTCCTGCTACCC
GTGAAGTCCTTGGCTCCCTCCCAAATGTATTCAGTGCACTCTGTTTGAATGCCCGAGGTCTTCAGTCTTTTGTTCAGTGTCAGCCTTTTG
AACGCCTCTTCAAAGTTCTTCTGTCTCCAGATTACCTCCCAGCCATGCGGAGGAGGAGAAGTTCTGATCCCCTTGGGGATACTGCATCCA
ACCTGGGGAGTGCTGTCGATGAGCTCATGAGACATCAGCCCACCCTTAAAACAGATGCAACGACTGCCATCATCAAGTTACTTGAAGAAA
TCTGTAATCTTGGAAGGGACCCCAAATACATCTGTCAGAAGCCATCAATCCAGAAGGCAGATGGCACTGCCACTGCTCCTCCCCCAAGGT
CTAATCATGCCGCAGAAGAAGCCTCTAGTGAGGATGAGGAGGAAGAGGAAGTACAGGCCATGCAGAGCTTTAATTCTACCCAGCAAAATG
AAACTGAGCCTAATCAGCAGGTTGTTGGTACAGAGGAACGTATTCCTATTCCCCTCATGGATTACATCCTTAATGTGTTGTGTTGGTGTT
GAAGAGGAGAAGGCTGCTGACATTGACCTCTACCACTGCCCCAACTGTGAAGTCTTGCATGGGCCCTCCATTATGAAAAAACGCCGTGGA
TCTTCAAAGGGGCATGATACACACAAGGGGAAACCAGTGAAGACCGGGAGCCCTACGTTCGTCAGAGAGCTCCGGAGTAGGACTTTTGAC
AGCTCAGATGAAGTGATTCTGAAGCCCACTGGAAATCAACTGACCGTGGAATTCCTGGAAGAAAATAGCTTCAGTGTGCCCATCCTGGTC
CTGAAGAAGGATGGGTTGGGCATGACGCTGCCCTCGCCATCATTCACTGTGAGGGATGTTGAACACTATGTTGGTTCTGACAAAGAGATT
GATGTGATTGATGTGACCCGCCAGGCTGACTGCAAGATGAAGCTTGGTGATTTTGTGAAATACTATTACAGCGGGAAGAGGGAGAAAGTC
CTCAATGTCATTAGTTTGGAATTCTCTGATACCAGACTTTCTAACCTTGTGGAGACACCGAAGATTGTTCGAAAGCTGTCATGGGTCGAA
AACTTGTGGCCAGAGGAATGTGTCTTTGAGAGACCCAATGTACAGAAGTACTGCCTCATGAGTGTGCGAGATAGCTATACAGACTTTCAC
ATTGACTTTGGTGGCACCTCTGTCTGGTACCATGTACTCAAGGGTGAAAAGATCTTCTACCTGATCCGCCCAACAAATGCCAATCTGACT
CTCTTTGAGTGCTGGAGCAGTTCCTCTAATCAGAATGAGATGTTCTTTGGGGACCAGGTGGACAAGTGCTACAAGTGTTCCGTGAAGCAA
GGACAGACACTTTTCATTCCCACAGGGTGGATCCATGCTGTGCTGACGCCTGTGGACTGCCTTGCCTTTGGAGGGAACTTCTTACACAGC
CTTAACATCGAGATGCAGCTCAAAGCCTATGAGATTGAGAAGCGGCTGAGCACAGCAGACCTCTTCAGATTCCCCAACTTTGAGACCATC
TGTTGGTATGTGGGAAAGCACATCCTGGACATCTTTCGCGGTTTGCGAGAGAACAGGAGACACCCTGCCTCCTACCTGGTCCATGGTGGC
AAAGCCTTGAACTTGGCCTTTAGAGCCTGGACAAGGAAAGAAGCTCTGCCAGACCATGAGGATGAGATCCCGGAGACAGTGCGAACCGTA
CAGCTCATTAAAGATCTGGCCAGGGAGATCCGCCTGGTGGAAGACATCTTCCAACAGAACGTTGGGAAGACGAGCAATATCTTTGGGCTG
CAGAGGATCTTCCCAGCCGGCTCCATTCCCCTAACCAGGCCAGCCCATTCCACTTCAGTGTCCATGTCCAGGCTGTCACTGCCCTCCAAA
AATGGTTCAAAGAAGAAAGGCCTGAAGCCCAAGGAACTCTTCAAGAAGGCAGAGCGAAAGGGCAAGGAGAGTTCAGCCTTGGGGCCTGCT
GGCCAGTTGAGCTATAATCTCATGGACACATACAGTCATCAGGCACTGAAGACAGGCTCTTTCCAGAAAGCAAAGTTCAACATCACTGGT
GCCTGCTTGAATGACTCAGATGACGACTCACCAGACTTGGACCTTGATGGAAATGAGAGCCCATTGGCCCTATTGATGTCTAACGGCAGT
ACGAAAAGGGTGAAGAGTTTATCCAAATCTCGGCGAACCAAGATAGCAAAGAAGGTAGACAAGGCTAGGCTGATGGCAGAACAGGTGATG
GAAGACGAATTTGACTTGGATTCAGATGATGAGCTGCAGATTGACGAGAGATTGGGAAAGGAGAAGGCGACCCTGATAATAAGACCAAAA
TTTCCCCGGAAATTGCCCCGTGCGAAGCCTTGCTCTGACCCCAACCGAGTTCGTGAACCAGGAGAAGTTGAGTTTGACATTGAGGAGGAC
TATACAACAGATGAGGACATGGTGGAAGGGGTTGAAGGCTATCAGACAGCAACCCCCGCTCCCGCCCAAGGTGCCAGCGAGGCCCCAGCT
TCTCCCAGCACTCAGGAGGCCATCCAGGGCATGCTGTGCATGGCCAACCTGCAGTCCTCATCGTCCTCACCGGCTACCTCTAGCCTGCAG
GCCTGGTGGACTGGGGGACAGGATCGAAGCAGTGGGAGCTCCAGCAGTGGGCTGGGCACAGTGTCTAACAGTCCTGCTTCCCAGCGCACC
CCAGGGAAGCGGCCCATCAAGCGGCCAGCATACTGGAGAACCGAGAGCGAGGAGGAGGAGGAGAACGCCAGTCTGGATGAACAGGACAGC
TTGGGAGCGTGCTTCAAGGATGCAGAGTATATCTATCCTTCACTGGAGTCTGATGATGATGACCCTGCTTTGAAATCTCGACCCAAGAAA
AAGAAGAATTCAGATGATGCTCCATGGAGTCCTAAAGCCCGCGTGACCCCAACTCTGCCGAAGCAGGACCGTCCTGTGCGTGAGGGGACC
CGGGTAGCCTCTATTGAGACAGGTTTGGCTGCAGCAGCTGCAAAGCTGGCCCAGCAGGTGAAGAAAATGAAGCTCTCATTAACTGACTCA
GGATAATACAGCCAGTAAATGGAGGAGACAACTCAAACTCATATCCTCTAACTTCAAATTTCATATTACTTTCTATTTAAATAAATGCTT

>38113_38113_1_HUWE1-PHF8_HUWE1_chrX_53635813_ENST00000342160_PHF8_chrX_54049276_ENST00000322659_length(amino acids)=943AA_BP=98
MQRLPSSSYLKKSVILEGTPNTSVRSHQSRRQMALPLLLPQGLIMPQKKPLVRMRRKRKYRPCRALILPSKMKLSLISRLLVQRNVFLFP
SWITSLMCCVGVEEEKAADIDLYHCPNCEVLHGPSIMKKRRGSSKGHDTHKGKPVKTGSPTFVRELRSRTFDSSDEVILKPTGNQLTVEF
LEENSFSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLVE
TPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGD
QVDKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYVGKHILDIFRGLREN
RRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEIPETVRTVQLIKDLAREIRLVEDIFQQNVGKTSNIFGLQRIFPAGSIPLTRPAHST
SVSMSRLSLPSKNGSKKKGLKPKELFKKAERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQKAKFNITGACLNDSDDDSPDLDLDGN
ESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKARLMAEQVMEDEFDLDSDDELQIDERLGKEKATLIIRPKFPRKLPRAKPCSDPNRVR
EPGEVEFDIEEDYTTDEDMVEGVEGYQTATPAPAQGASEAPASPSTQEAIQGMLCMANLQSSSSSPATSSLQAWWTGGQDRSSGSSSSGL
GTVSNSPASQRTPGKRPIKRPAYWRTESEEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDDAPWSPKARVTPT

--------------------------------------------------------------
>38113_38113_2_HUWE1-PHF8_HUWE1_chrX_53635813_ENST00000342160_PHF8_chrX_54049276_ENST00000338154_length(transcript)=8236nt_BP=2777nt
TCCGCCCCTCACTGCTTCGTTAGGTTGTGCGTCATTTGCTTTTCGCTTCGCGTAGGGTGAAGCTGTAGCTACTTCGGCTTTGGTGGGAGG
GAGGAGGGGTCTGGAAAGGGCTGGGCTCAGGCTTTTCCCGTCCGGTAGAGGTTCTCGCGGGATCGCGCGGAGGCGGCGGTGGCTCGGTTA
CTGACTGCAGTAGCCGCGGAGGCGGCGGCAAGGTCTTCGGCTCGTGCCGTTCTAAGCCGGAGAATTCTCGCGGGAGCAGGGTTACGTCCT
CGTGGGATTCGTTGGCGGTGGCTGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTAGTGATCCAGAGAAACCAGCAGGCCAACTTGGTCA
GGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTATGATTGGCTGTGATTTTAGATCGTAAAGCTGAAAA
TTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCTGCAGACTGCAGAGCCTTAATAGACAAACTCAAAG
TTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATTGGAAAGTGCGAGTTATATCACTGGGTGGACCTGT
TGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCATGGATGCTCGTATGTGATAGGCCAGAAAGAGAGC
AACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTACAGCTTTTCCCGGCATCTGTACAGTTCCATAGAGC
ATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAATCTCCTATATGTATTTAGCAAAAGATCAAACTACA
TCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTGGCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTG
GACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACTACACTACACTTTGAATTCTATGCAGATCCTGGGG
CCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATAGAGCAACTTGACAAGATTTCAGAAAGCCCTTCTG
AAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTGTTATTTACACACATACGACTGGCCCATGGCTTTT
CTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATATTAGTGTATTCCAATGCCTTGCAGGAATCAGCAA
ACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACGGATAAGCAGCTTATGGAGATTAAAGCAGCTTCTT
TACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATTATTGACTGTACTGGAACTGCCTCCTACCATGGAT
TTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGATCCATACCCTCACCAGTTTGCCACTGCTCTCTTCT
CTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGTGGAATGATGGAAGCCTTATTGAAGGTCATAAAGT
TTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTTGACCTTATCACCAACCTGGATATGGCAGCTTTTC
AATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTGTGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAA
AGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGATGGAGTCCAGTGTATTCCACAACGAGCAGCACTTC
TGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGATGGCATACGACATGTGATGGATGGTTCTCTGCCTA
CCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTCCTAGCTACTGAAGTGGTGACTGTGTTTGTATTTC
AAGAACCATCACTGCTCTCCTCACTCCAGGACAATGGATTGACAGATGTCATGCTGCATGCACTGCTTATCAAAGATGTTCCTGCTACCC
GTGAAGTCCTTGGCTCCCTCCCAAATGTATTCAGTGCACTCTGTTTGAATGCCCGAGGTCTTCAGTCTTTTGTTCAGTGTCAGCCTTTTG
AACGCCTCTTCAAAGTTCTTCTGTCTCCAGATTACCTCCCAGCCATGCGGAGGAGGAGAAGTTCTGATCCCCTTGGGGATACTGCATCCA
ACCTGGGGAGTGCTGTCGATGAGCTCATGAGACATCAGCCCACCCTTAAAACAGATGCAACGACTGCCATCATCAAGTTACTTGAAGAAA
TCTGTAATCTTGGAAGGGACCCCAAATACATCTGTCAGAAGCCATCAATCCAGAAGGCAGATGGCACTGCCACTGCTCCTCCCCCAAGGT
CTAATCATGCCGCAGAAGAAGCCTCTAGTGAGGATGAGGAGGAAGAGGAAGTACAGGCCATGCAGAGCTTTAATTCTACCCAGCAAAATG
AAACTGAGCCTAATCAGCAGGTTGTTGGTACAGAGGAACGTATTCCTATTCCCCTCATGGATTACATCCTTAATGTGTTGTGTTGGTGTT
GAAGAGGAGAAGGCTGCTGACATTGACCTCTACCACTGCCCCAACTGTGAAGTCTTGCATGGGCCCTCCATTATGAAAAAACGCCGTGGA
TCTTCAAAGGGGCATGATACACACAAGGGGAAACCAGTGAAGACCGGGAGCCCTACGTTCGTCAGAGAGCTCCGGAGTAGGACTTTTGAC
AGCTCAGATGAAGTGATTCTGAAGCCCACTGGAAATCAACTGACCGTGGAATTCCTGGAAGAAAATAGCTTCAGTGTGCCCATCCTGGTC
CTGAAGAAGGATGGGTTGGGCATGACGCTGCCCTCGCCATCATTCACTGTGAGGGATGTTGAACACTATGTTGGTTCTGACAAAGAGATT
GATGTGATTGATGTGACCCGCCAGGCTGACTGCAAGATGAAGCTTGGTGATTTTGTGAAATACTATTACAGCGGGAAGAGGGAGAAAGTC
CTCAATGTCATTAGTTTGGAATTCTCTGATACCAGACTTTCTAACCTTGTGGAGACACCGAAGATTGTTCGAAAGCTGTCATGGGTCGAA
AACTTGTGGCCAGAGGAATGTGTCTTTGAGAGACCCAATGTACAGAAGTACTGCCTCATGAGTGTGCGAGATAGCTATACAGACTTTCAC
ATTGACTTTGGTGGCACCTCTGTCTGGTACCATGTACTCAAGGGTGAAAAGATCTTCTACCTGATCCGCCCAACAAATGCCAATCTGACT
CTCTTTGAGTGCTGGAGCAGTTCCTCTAATCAGAATGAGATGTTCTTTGGGGACCAGGTGGACAAGTGCTACAAGTGTTCCGTGAAGCAA
GGACAGACACTTTTCATTCCCACAGGGTGGATCCATGCTGTGCTGACGCCTGTGGACTGCCTTGCCTTTGGAGGGAACTTCTTACACAGC
CTTAACATCGAGATGCAGCTCAAAGCCTATGAGATTGAGAAGCGGCTGAGCACAGCAGACCTCTTCAGATTCCCCAACTTTGAGACCATC
TGTTGGTATGTGGGAAAGCACATCCTGGACATCTTTCGCGGTTTGCGAGAGAACAGGAGACACCCTGCCTCCTACCTGGTCCATGGTGGC
AAAGCCTTGAACTTGGCCTTTAGAGCCTGGACAAGGAAAGAAGCTCTGCCAGACCATGAGGATGAGATCCCGGAGACAGTGCGAACCGTA
CAGCTCATTAAAGATCTGGCCAGGGAGATCCGCCTGGTGGAAGACATCTTCCAACAGAACGTTGGGAAGACGAGCAATATCTTTGGGCTG
CAGAGGATCTTCCCAGCCGGCTCCATTCCCCTAACCAGGCCAGCCCATTCCACTTCAGTGTCCATGTCCAGGCTGTCACTGCCCTCCAAA
AATGGTTCAAAGAAGAAAGGCCTGAAGCCCAAGGAACTCTTCAAGAAGGCAGAGCGAAAGGGCAAGGAGAGTTCAGCCTTGGGGCCTGCT
GGCCAGTTGAGCTATAATCTCATGGACACATACAGTCATCAGGCACTGAAGACAGGCTCTTTCCAGAAAGCAAAGTTCAACATCACTGGT
GCCTGCTTGAATGACTCAGATGACGACTCACCAGACTTGGACCTTGATGGAAATGAGAGCCCATTGGCCCTATTGATGTCTAACGGCAGT
ACGAAAAGGGTGAAGAGTTTATCCAAATCTCGGCGAACCAAGATAGCAAAGAAGGTAGACAAGGCTAGGCTGATGGCAGAACAGGTGATG
GAAGACGAATTTGACTTGGATTCAGATGATGAGCTGCAGATTGACGAGAGATTGGGAAAGGAGAAGGCGACCCTGATAATAAGACCAAAA
TTTCCCCGGAAATTGCCCCGTGCGAAGCCTTGCTCTGACCCCAACCGAGTTCGTGAACCAGGAGAAGTTGAGTTTGACATTGAGGAGGAC
TATACAACAGATGAGGACATGGTGGAAGGGGTTGAAGGCAAGCTTGGGAATGGTAGTGGCGCTGGTGGCATTCTTGATCTGCTCAAGGCC
AGCAGGCAGGTGGGGGGACCTGACTATGCTGCCCTCACCGAGGCCCCAGCTTCTCCCAGCACTCAGGAGGCCATCCAGGGCATGCTGTGC
ATGGCCAACCTGCAGTCCTCATCGTCCTCACCGGCTACCTCTAGCCTGCAGGCCTGGTGGACTGGGGGACAGGATCGAAGCAGTGGGAGC
TCCAGCAGTGGGCTGGGCACAGTGTCTAACAGTCCTGCTTCCCAGCGCACCCCAGGGAAGCGGCCCATCAAGCGGCCAGCATACTGGAGA
ACCGAGAGCGAGGAGGAGGAGGAGAACGCCAGTCTGGATGAACAGGACAGCTTGGGAGCGTGCTTCAAGGATGCAGAGTATATCTATCCT
TCACTGGAGTCTGATGATGATGACCCTGCTTTGAAATCTCGACCCAAGAAAAAGAAGAATTCAGATGATGCTCCATGGAGTCCTAAAGCC
CGCGTGACCCCAACTCTGCCGAAGCAGGACCGTCCTGTGCGTGAGGGGACCCGGGTAGCCTCTATTGAGACAGGTTTGGCTGCAGCAGCT
GCAAAGCTGGCCCAGCAGGAGCTACAGAAGGCCCAAAAGAAGAAATATATCAAGAAGAAGCCTTTGCTGAAGGAGGTAGAACAGCCTCGC
CCTCAAGACTCCAATCTCAGTCTGACAGTACCAGCCCCCACTGTGGCTGCCACACCACAACTTGTCACCTCCTCCTCACCCCTGCCTCCT
CCTGAGCCTAAACAAGAGGCCCTGTCAGGAAGTCTCGCTGACCATGAGTACACCGCTCGTCCCAATGCCTTTGGCATGGCCCAGGCAAAC
CGCAGCACCACACCTATGGCCCCCGGTGTCTTCTTGACCCAGCGGCGCCCTTCAGTTGGCTCCCAGAGCAATCAGGCAGGACAAGGAAAG
CGTCCCAAAAAGGGCCTGGCCACAGCAAAGCAGAGACTCGGCCGTATCCTGAAAATCCACAGAAATGGCAAACTACTTCTGTGAGCCCTC
CTGTGTCCCACCCCTCACCCCTTTACCCCCATTGCCTTCTCCATTGTCAACTCTTGGGGCACTCCTGGATCCTATCTGCCCTGGACAAGG
TGCTGAGGTGCATTGTCCTGCTTTCTTGGGACTTACCAAAGGCACGGACCCCTCCACCGACTCCTTCTAGTTCCCTTCCCCACTTTCACT
AGAGCATCCTGCCTGCCTTCTCCACTGAGGAGCAGGTAAATGGGAGAGGTTTCCAGCTGACTAGAACCCTCTTTTCTACTCGTCCAAACC
ACTCCCGTCACCTGCCTTGTCTGTTCTTTATTCTTCATCCCCCGCTAGAGCTGGAAGGCAGGATGAGGAGAGGTATGAAGGAGCCTGAGC
CATGAAGTGGGAAGCCCAGTGCTTGACACTTTCTGCAACTCTAGCCCTATATCCAGAAGCCTGCCCACCTCCACCCATTCTGTTTGCCCC
ATTTCCCCAGTCCAGTGGACATGCCCCACCTCCAGACTTGCTCATGGGAGAAGGCTGTGGTCTCTGCCCCCTCTTGCCAAATGCTTCATG
GAAATGAAGAGGAAGGCCTAGAGCCTCCTTCCTGCCCCACTGTGGGCCATTTCCAGAAGTGGCCTAGAAATGCCAACTTCACTTACCTTT
CAAAAGAAAGGTGATTCCTATCACTTGTCAAGGTAGGGAGAGGTCAGATGCCCAAGCCTTTGACCACGGTTTTGTAGCCTGTTGGAGGAA
GCTACTTTTAGCTGGCTACACATGAGGCCACTTGTTTTAGGGTGAGCTCCAGGGATTTGCCTGGATTTTGAAATCATGTAGAACATTATC
CACGTGGCTGTGGCTGTGGCTGTGGCTGGGCCCTGGCAGGTGGAAAACCATCTCCCAGAAACCTGAAAGCACCTGCCAATGACGCAGATA
ACCCTGGCCCTACAGCCTGCTTGCTCCGCCTATACCACAGAGCACAGCCTGGACATTATGGAGGGTGTGGCGGGACGGCCCACACCTGGG
TCCTCCATCGGGAACTTTTCATGCTTCTTTCTCCACCTGAGGTCTTGGTCTGAAGAAGACCTCAGGACTCACATCTTCACTCCTGGGCCT
TTGCACTTCCAGACGACAGGTCATCGTTCAAGCAGAATGCAGACAGGCCATTCACGAGCCCAAGTTGAAGAGAAGAGACGCCCATCCGTG
AAGGAGCAGACCATCCATCCGATCCTCCCCTTCCCCTGTCCTTCCTTCGTGGATTGTCTCCATTGTCCAGACAGTGCCCCCACCTCCCAC
CGCCTTGCCTCACTGGCAATCTGGACTCGATGGAGAACATCCCCCCACCTCCATTTGGCACTACCCAAGTGGAGTGTACCCTTGCCCTTT
CCACCTGTACCACCCACTCCAACCTCACCCCAGCTTGCCCAATGCTTCTGGGGAATTTAATAGCTACCATGCAGGCCACAGGGAATTTGT
GAGGCTTCTTTTGTCATCTTTGTATCTCCAGTTTGTCTTTCTTTTCTCCATAGCCCTGCCTCTACTTTCCTTCCTTGGAATCAGGGGTTC
CTTTAGCCCATTTGCTTTCTCTACCTTGGGGACCCCAGGGGCCAAGCAGTTCTCCATCTAGTCACACCAAAGGCAAAAAGCCTGGCTACC
TCCCCCCTAGCACGTGAGTCCCTACTCCCCTCCCCTCTGTTTCTGCCCAGCTTTGCTTATTTTGGGGATTTCAAGGCAGCAGAGGGTAGT
GAGGGGAGAGCAGGAGAAGCCTCTGTCCTGTATAGGCAACTGCCTGACTATGCGGTGACTGCTGTAACCAAGATCAGGTCCCCAGCCCTT
TTGTCCATTAACACCCCTTCTTGATCTTTCAAAGGCAGCTAATTGCTAGCAAATCCCCCCGATTCCGGCCTTTTCCCTCTATTTCTTTGT
TAGAAGTTTTCTGTGGAGCTGAAACCCAGCCTCTGTTTGACTGGGTTTCATTTAGCTTAGTTGGGTTCTTAGAGCCCCCTGTTTGTTGTT
TTGTGTTGTTTCCAATGAAAAGCAAGTTTACCCTCAGAGTTATGCTTTTCCAAAGAGGCTGATGTCTTTGTTTTTGTTTTTTTTAATGTT
TCAGGTTCTAAGTGAAGTGAGTTGGGGAGGGGTTGGGAGTGTTAGTAATCAAGGTTTAGAACACCATGAGATAGTTACCCCTGATCTCCA
GTCCCTAGCTGGGGGCTGGACAGGGGGAAGGGAGAGAGGATTTCTATTCACCTTTAATATATTTTTACAAAAAAAGCAAACAATTTAAAA
ACAAGCCCACCGCTTCTGTACATGTCTAAATATATTTTTAGAAGTGGGTAGGATTGTGAATTTCTGATGCAGGGCCTTTTTATAAATAGG
TTAGGGTAGCATCATTCAGACTTCTCTGTTGTTTTTGTCCCTGTCTTTTTCTTATGTTGTGTTACTAATGTAATTTATATTTTTTTTAGA

>38113_38113_2_HUWE1-PHF8_HUWE1_chrX_53635813_ENST00000342160_PHF8_chrX_54049276_ENST00000338154_length(amino acids)=1089AA_BP=98
MQRLPSSSYLKKSVILEGTPNTSVRSHQSRRQMALPLLLPQGLIMPQKKPLVRMRRKRKYRPCRALILPSKMKLSLISRLLVQRNVFLFP
SWITSLMCCVGVEEEKAADIDLYHCPNCEVLHGPSIMKKRRGSSKGHDTHKGKPVKTGSPTFVRELRSRTFDSSDEVILKPTGNQLTVEF
LEENSFSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLVE
TPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGD
QVDKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYVGKHILDIFRGLREN
RRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEIPETVRTVQLIKDLAREIRLVEDIFQQNVGKTSNIFGLQRIFPAGSIPLTRPAHST
SVSMSRLSLPSKNGSKKKGLKPKELFKKAERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQKAKFNITGACLNDSDDDSPDLDLDGN
ESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKARLMAEQVMEDEFDLDSDDELQIDERLGKEKATLIIRPKFPRKLPRAKPCSDPNRVR
EPGEVEFDIEEDYTTDEDMVEGVEGKLGNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPATSSLQA
WWTGGQDRSSGSSSSGLGTVSNSPASQRTPGKRPIKRPAYWRTESEEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKK
KNSDDAPWSPKARVTPTLPKQDRPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLLKEVEQPRPQDSNLSLTVPAPTVAAT
PQLVTSSSPLPPPEPKQEALSGSLADHEYTARPNAFGMAQANRSTTPMAPGVFLTQRRPSVGSQSNQAGQGKRPKKGLATAKQRLGRILK

--------------------------------------------------------------
>38113_38113_3_HUWE1-PHF8_HUWE1_chrX_53635813_ENST00000342160_PHF8_chrX_54049276_ENST00000338946_length(transcript)=6825nt_BP=2777nt
TCCGCCCCTCACTGCTTCGTTAGGTTGTGCGTCATTTGCTTTTCGCTTCGCGTAGGGTGAAGCTGTAGCTACTTCGGCTTTGGTGGGAGG
GAGGAGGGGTCTGGAAAGGGCTGGGCTCAGGCTTTTCCCGTCCGGTAGAGGTTCTCGCGGGATCGCGCGGAGGCGGCGGTGGCTCGGTTA
CTGACTGCAGTAGCCGCGGAGGCGGCGGCAAGGTCTTCGGCTCGTGCCGTTCTAAGCCGGAGAATTCTCGCGGGAGCAGGGTTACGTCCT
CGTGGGATTCGTTGGCGGTGGCTGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTAGTGATCCAGAGAAACCAGCAGGCCAACTTGGTCA
GGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTATGATTGGCTGTGATTTTAGATCGTAAAGCTGAAAA
TTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCTGCAGACTGCAGAGCCTTAATAGACAAACTCAAAG
TTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATTGGAAAGTGCGAGTTATATCACTGGGTGGACCTGT
TGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCATGGATGCTCGTATGTGATAGGCCAGAAAGAGAGC
AACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTACAGCTTTTCCCGGCATCTGTACAGTTCCATAGAGC
ATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAATCTCCTATATGTATTTAGCAAAAGATCAAACTACA
TCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTGGCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTG
GACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACTACACTACACTTTGAATTCTATGCAGATCCTGGGG
CCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATAGAGCAACTTGACAAGATTTCAGAAAGCCCTTCTG
AAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTGTTATTTACACACATACGACTGGCCCATGGCTTTT
CTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATATTAGTGTATTCCAATGCCTTGCAGGAATCAGCAA
ACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACGGATAAGCAGCTTATGGAGATTAAAGCAGCTTCTT
TACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATTATTGACTGTACTGGAACTGCCTCCTACCATGGAT
TTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGATCCATACCCTCACCAGTTTGCCACTGCTCTCTTCT
CTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGTGGAATGATGGAAGCCTTATTGAAGGTCATAAAGT
TTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTTGACCTTATCACCAACCTGGATATGGCAGCTTTTC
AATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTGTGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAA
AGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGATGGAGTCCAGTGTATTCCACAACGAGCAGCACTTC
TGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGATGGCATACGACATGTGATGGATGGTTCTCTGCCTA
CCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTCCTAGCTACTGAAGTGGTGACTGTGTTTGTATTTC
AAGAACCATCACTGCTCTCCTCACTCCAGGACAATGGATTGACAGATGTCATGCTGCATGCACTGCTTATCAAAGATGTTCCTGCTACCC
GTGAAGTCCTTGGCTCCCTCCCAAATGTATTCAGTGCACTCTGTTTGAATGCCCGAGGTCTTCAGTCTTTTGTTCAGTGTCAGCCTTTTG
AACGCCTCTTCAAAGTTCTTCTGTCTCCAGATTACCTCCCAGCCATGCGGAGGAGGAGAAGTTCTGATCCCCTTGGGGATACTGCATCCA
ACCTGGGGAGTGCTGTCGATGAGCTCATGAGACATCAGCCCACCCTTAAAACAGATGCAACGACTGCCATCATCAAGTTACTTGAAGAAA
TCTGTAATCTTGGAAGGGACCCCAAATACATCTGTCAGAAGCCATCAATCCAGAAGGCAGATGGCACTGCCACTGCTCCTCCCCCAAGGT
CTAATCATGCCGCAGAAGAAGCCTCTAGTGAGGATGAGGAGGAAGAGGAAGTACAGGCCATGCAGAGCTTTAATTCTACCCAGCAAAATG
AAACTGAGCCTAATCAGCAGGTTGTTGGTACAGAGGAACGTATTCCTATTCCCCTCATGGATTACATCCTTAATGTGTTGTGTTGGTGTT
GAAGAGGAGAAGGCTGCTGACATTGACCTCTACCACTGCCCCAACTGTGAAGTCTTGCATGGGCCCTCCATTATGAAAAAACGCCGTGGA
TCTTCAAAGGGGCATGATACACACAAGGGGAAACCAGTGAAGACCGGGAGCCCTACGTTCGTCAGAGAGCTCCGGAGTAGGACTTTTGAC
AGCTCAGATGAAGTGATTCTGAAGCCCACTGGAAATCAACTGACCGTGGAATTCCTGGAAGAAAATAGCTTCAGTGTGCCCATCCTGGTC
CTGAAGAAGGATGGGTTGGGCATGACGCTGCCCTCGCCATCATTCACTGTGAGGGATGTTGAACACTATGTTGGTTCTGACAAAGAGATT
GATGTGATTGATGTGACCCGCCAGGCTGACTGCAAGATGAAGCTTGGTGATTTTGTGAAATACTATTACAGCGGGAAGAGGGAGAAAGTC
CTCAATGTCATTAGTTTGGAATTCTCTGATACCAGACTTTCTAACCTTGTGGAGACACCGAAGATTGTTCGAAAGCTGTCATGGGTCGAA
AACTTGTGGCCAGAGGAATGTGTCTTTGAGAGACCCAATGTACAGAAGTACTGCCTCATGAGTGTGCGAGATAGCTATACAGACTTTCAC
ATTGACTTTGGTGGCACCTCTGTCTGGTACCATGTACTCAAGGGTGAAAAGATCTTCTACCTGATCCGCCCAACAAATGCCAATCTGACT
CTCTTTGAGTGCTGGAGCAGTTCCTCTAATCAGAATGAGATGTTCTTTGGGGACCAGGTGGACAAGTGCTACAAGTGTTCCGTGAAGCAA
GGACAGACACTTTTCATTCCCACAGGGTGGATCCATGCTGTGCTGACGCCTGTGGACTGCCTTGCCTTTGGAGGGAACTTCTTACACAGC
CTTAACATCGAGATGCAGCTCAAAGCCTATGAGATTGAGAAGCGGCTGAGCACAGCAGACCTCTTCAGATTCCCCAACTTTGAGACCATC
TGTTGGTATGTGGGAAAGCACATCCTGGACATCTTTCGCGGTTTGCGAGAGAACAGGAGACACCCTGCCTCCTACCTGGTCCATGGTGGC
AAAGCCTTGAACTTGGCCTTTAGAGCCTGGACAAGGAAAGAAGCTCTGCCAGACCATGAGGATGAGATCCCGGAGACAGTGCGAACCGTA
CAGCTCATTAAAGATCTGGCCAGGGAGATCCGCCTGGTGGAATTCAACATCACTGGTGCCTGCTTGAATGACTCAGATGACGACTCACCA
GACTTGGACCTTGATGGAAATGAGAGCCCATTGGCCCTATTGATGTCTAACGGCAGTACGAAAAGGGTGAAGAGTTTATCCAAATCTCGG
CGAACCAAGATAGCAAAGAAGGTAGACAAGGCTAGGCTGATGGCAGAACAGGTGATGGAAGACGAATTTGACTTGGATTCAGATGATGAG
CTGCAGATTGACGAGAGATTGGGAAAGGAGAAGGCGACCCTGATAATAAGACCAAAATTTCCCCGGAAATTGCCCCGTGCGAAGCCTTGC
TCTGACCCCAACCGAGTTCGTGAACCAGGAGAAGTTGAGTTTGACATTGAGGAGGACTATACAACAGATGAGGACATGGTGGAAGGGGTT
GAAGGCAAGCTTGGGAATGGTAGTGGCGCTGGTGGCATTCTTGATCTGCTCAAGGCCAGCAGGCAGGTGGGGGGACCTGACTATGCTGCC
CTCACCGAGGCCCCAGCTTCTCCCAGCACTCAGGAGGCCATCCAGGGCATGCTGTGCATGGCCAACCTGCAGTCCTCATCGTCCTCACCG
GCTACCTCTAGCCTGCAGGCCTGGTGGACTGGGGGACAGGATCGAAGCAGTGGGAGCTCCAGCAGTGGGCTGGGCACAGTGTCTAACAGT
CCTGCTTCCCAGCGCACCCCAGGGAAGCGGCCCATCAAGCGGCCAGCATACTGGAGAACCGAGAGCGAGGAGGAGGAGGAGAACGCCAGT
CTGGATGAACAGGACAGCTTGGGAGCGTGCTTCAAGGATGCAGAGTATATCTATCCTTCACTGGAGTCTGATGATGATGACCCTGCTTTG
AAATCTCGACCCAAGAAAAAGAAGAATTCAGATGATGCTCCATGGAGTCCTAAAGCCCGCGTGACCCCAACTCTGCCGAAGCAGGACCGT
CCTGTGCGTGAGGGGACCCGGGTAGCCTCTATTGAGACAGGTTTGGCTGCAGCAGCTGCAAAGCTGGCCCAGCAGGAGCTACAGAAGGCC
CAAAAGAAGAAATATATCAAGAAGAAGCCTTTGCTGAAGGAGGTAGAACAGCCTCGCCCTCAAGACTCCAATCTCAGTCTGACAGTACCA
GCCCCCACTGTGGCTGCCACACCACAACTTGTCACCTCCTCCTCACCCCTGCCTCCTCCTGAGCCTAAACAAGAGGCCCTGTCAGGAAGT
CTCGCTGACCATGAGTACACCGCTCGTCCCAATGCCTTTGGCATGGCCCAGGCAAACCGCAGCACCACACCTATGGCCCCCGGTGTCTTC
TTGACCCAGCGGCGCCCTTCAGTTGGCTCCCAGAGCAATCAGGCAGGACAAGGAAAGCGTCCCAAAAAGGGCCTGGCCACAGCAAAGCAG
AGACTCGGCCGTATCCTGAAAATCCACAGAAATGGCAAACTACTTCTACGACAGGTCATCGTTCAAGCAGAATGCAGACAGGCCATTCAC
GAGCCCAAGTTGAAGAGAAGAGACGCCCATCCGTGAAGGAGCAGACCATCCATCCGATCCTCCCCTTCCCCTGTCCTTCCTTCGTGGATT
GTCTCCATTGTCCAGACAGTGCCCCCACCTCCCACCGCCTTGCCTCACTGGCAATCTGGACTCGATGGAGAACATCCCCCCACCTCCATT
TGGCACTACCCAAGTGGAGTGTACCCTTGCCCTTTCCACCTGTACCACCCACTCCAACCTCACCCCAGCTTGCCCAATGCTTCTGGGGAA
TTTAATAGCTACCATGCAGGCCACAGGGAATTTGTGAGGCTTCTTTTGTCATCTTTGTATCTCCAGTTTGTCTTTCTTTTCTCCATAGCC
CTGCCTCTACTTTCCTTCCTTGGAATCAGGGGTTCCTTTAGCCCATTTGCTTTCTCTACCTTGGGGACCCCAGGGGCCAAGCAGTTCTCC
ATCTAGTCACACCAAAGGCAAAAAGCCTGGCTACCTCCCCCCTAGCACGTGAGTCCCTACTCCCCTCCCCTCTGTTTCTGCCCAGCTTTG
CTTATTTTGGGGATTTCAAGGCAGCAGAGGGTAGTGAGGGGAGAGCAGGAGAAGCCTCTGTCCTGTATAGGCAACTGCCTGACTATGCGG
TGACTGCTGTAACCAAGATCAGGTCCCCAGCCCTTTTGTCCATTAACACCCCTTCTTGATCTTTCAAAGGCAGCTAATTGCTAGCAAATC
CCCCCGATTCCGGCCTTTTCCCTCTATTTCTTTGTTAGAAGTTTTCTGTGGAGCTGAAACCCAGCCTCTGTTTGACTGGGTTTCATTTAG
CTTAGTTGGGTTCTTAGAGCCCCCTGTTTGTTGTTTTGTGTTGTTTCCAATGAAAAGCAAGTTTACCCTCAGAGTTATGCTTTTCCAAAG
AGGCTGATGTCTTTGTTTTTGTTTTTTTTAATGTTTCAGGTTCTAAGTGAAGTGAGTTGGGGAGGGGTTGGGAGTGTTAGTAATCAAGGT
TTAGAACACCATGAGATAGTTACCCCTGATCTCCAGTCCCTAGCTGGGGGCTGGACAGGGGGAAGGGAGAGAGGATTTCTATTCACCTTT
AATATATTTTTACAAAAAAAGCAAACAATTTAAAAACAAGCCCACCGCTTCTGTACATGTCTAAATATATTTTTAGAAGTGGGTAGGATT
GTGAATTTCTGATGCAGGGCCTTTTTATAAATAGGTTAGGGTAGCATCATTCAGACTTCTCTGTTGTTTTTGTCCCTGTCTTTTTCTTAT

>38113_38113_3_HUWE1-PHF8_HUWE1_chrX_53635813_ENST00000342160_PHF8_chrX_54049276_ENST00000338946_length(amino acids)=1013AA_BP=98
MQRLPSSSYLKKSVILEGTPNTSVRSHQSRRQMALPLLLPQGLIMPQKKPLVRMRRKRKYRPCRALILPSKMKLSLISRLLVQRNVFLFP
SWITSLMCCVGVEEEKAADIDLYHCPNCEVLHGPSIMKKRRGSSKGHDTHKGKPVKTGSPTFVRELRSRTFDSSDEVILKPTGNQLTVEF
LEENSFSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLVE
TPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGD
QVDKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYVGKHILDIFRGLREN
RRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEIPETVRTVQLIKDLAREIRLVEFNITGACLNDSDDDSPDLDLDGNESPLALLMSNG
STKRVKSLSKSRRTKIAKKVDKARLMAEQVMEDEFDLDSDDELQIDERLGKEKATLIIRPKFPRKLPRAKPCSDPNRVREPGEVEFDIEE
DYTTDEDMVEGVEGKLGNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPATSSLQAWWTGGQDRSSG
SSSSGLGTVSNSPASQRTPGKRPIKRPAYWRTESEEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDDAPWSPK
ARVTPTLPKQDRPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLLKEVEQPRPQDSNLSLTVPAPTVAATPQLVTSSSPLP
PPEPKQEALSGSLADHEYTARPNAFGMAQANRSTTPMAPGVFLTQRRPSVGSQSNQAGQGKRPKKGLATAKQRLGRILKIHRNGKLLLRQ

--------------------------------------------------------------
>38113_38113_4_HUWE1-PHF8_HUWE1_chrX_53635813_ENST00000342160_PHF8_chrX_54049276_ENST00000357988_length(transcript)=8236nt_BP=2777nt
TCCGCCCCTCACTGCTTCGTTAGGTTGTGCGTCATTTGCTTTTCGCTTCGCGTAGGGTGAAGCTGTAGCTACTTCGGCTTTGGTGGGAGG
GAGGAGGGGTCTGGAAAGGGCTGGGCTCAGGCTTTTCCCGTCCGGTAGAGGTTCTCGCGGGATCGCGCGGAGGCGGCGGTGGCTCGGTTA
CTGACTGCAGTAGCCGCGGAGGCGGCGGCAAGGTCTTCGGCTCGTGCCGTTCTAAGCCGGAGAATTCTCGCGGGAGCAGGGTTACGTCCT
CGTGGGATTCGTTGGCGGTGGCTGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTAGTGATCCAGAGAAACCAGCAGGCCAACTTGGTCA
GGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTATGATTGGCTGTGATTTTAGATCGTAAAGCTGAAAA
TTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCTGCAGACTGCAGAGCCTTAATAGACAAACTCAAAG
TTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATTGGAAAGTGCGAGTTATATCACTGGGTGGACCTGT
TGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCATGGATGCTCGTATGTGATAGGCCAGAAAGAGAGC
AACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTACAGCTTTTCCCGGCATCTGTACAGTTCCATAGAGC
ATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAATCTCCTATATGTATTTAGCAAAAGATCAAACTACA
TCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTGGCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTG
GACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACTACACTACACTTTGAATTCTATGCAGATCCTGGGG
CCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATAGAGCAACTTGACAAGATTTCAGAAAGCCCTTCTG
AAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTGTTATTTACACACATACGACTGGCCCATGGCTTTT
CTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATATTAGTGTATTCCAATGCCTTGCAGGAATCAGCAA
ACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACGGATAAGCAGCTTATGGAGATTAAAGCAGCTTCTT
TACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATTATTGACTGTACTGGAACTGCCTCCTACCATGGAT
TTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGATCCATACCCTCACCAGTTTGCCACTGCTCTCTTCT
CTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGTGGAATGATGGAAGCCTTATTGAAGGTCATAAAGT
TTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTTGACCTTATCACCAACCTGGATATGGCAGCTTTTC
AATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTGTGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAA
AGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGATGGAGTCCAGTGTATTCCACAACGAGCAGCACTTC
TGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGATGGCATACGACATGTGATGGATGGTTCTCTGCCTA
CCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTCCTAGCTACTGAAGTGGTGACTGTGTTTGTATTTC
AAGAACCATCACTGCTCTCCTCACTCCAGGACAATGGATTGACAGATGTCATGCTGCATGCACTGCTTATCAAAGATGTTCCTGCTACCC
GTGAAGTCCTTGGCTCCCTCCCAAATGTATTCAGTGCACTCTGTTTGAATGCCCGAGGTCTTCAGTCTTTTGTTCAGTGTCAGCCTTTTG
AACGCCTCTTCAAAGTTCTTCTGTCTCCAGATTACCTCCCAGCCATGCGGAGGAGGAGAAGTTCTGATCCCCTTGGGGATACTGCATCCA
ACCTGGGGAGTGCTGTCGATGAGCTCATGAGACATCAGCCCACCCTTAAAACAGATGCAACGACTGCCATCATCAAGTTACTTGAAGAAA
TCTGTAATCTTGGAAGGGACCCCAAATACATCTGTCAGAAGCCATCAATCCAGAAGGCAGATGGCACTGCCACTGCTCCTCCCCCAAGGT
CTAATCATGCCGCAGAAGAAGCCTCTAGTGAGGATGAGGAGGAAGAGGAAGTACAGGCCATGCAGAGCTTTAATTCTACCCAGCAAAATG
AAACTGAGCCTAATCAGCAGGTTGTTGGTACAGAGGAACGTATTCCTATTCCCCTCATGGATTACATCCTTAATGTGTTGTGTTGGTGTT
GAAGAGGAGAAGGCTGCTGACATTGACCTCTACCACTGCCCCAACTGTGAAGTCTTGCATGGGCCCTCCATTATGAAAAAACGCCGTGGA
TCTTCAAAGGGGCATGATACACACAAGGGGAAACCAGTGAAGACCGGGAGCCCTACGTTCGTCAGAGAGCTCCGGAGTAGGACTTTTGAC
AGCTCAGATGAAGTGATTCTGAAGCCCACTGGAAATCAACTGACCGTGGAATTCCTGGAAGAAAATAGCTTCAGTGTGCCCATCCTGGTC
CTGAAGAAGGATGGGTTGGGCATGACGCTGCCCTCGCCATCATTCACTGTGAGGGATGTTGAACACTATGTTGGTTCTGACAAAGAGATT
GATGTGATTGATGTGACCCGCCAGGCTGACTGCAAGATGAAGCTTGGTGATTTTGTGAAATACTATTACAGCGGGAAGAGGGAGAAAGTC
CTCAATGTCATTAGTTTGGAATTCTCTGATACCAGACTTTCTAACCTTGTGGAGACACCGAAGATTGTTCGAAAGCTGTCATGGGTCGAA
AACTTGTGGCCAGAGGAATGTGTCTTTGAGAGACCCAATGTACAGAAGTACTGCCTCATGAGTGTGCGAGATAGCTATACAGACTTTCAC
ATTGACTTTGGTGGCACCTCTGTCTGGTACCATGTACTCAAGGGTGAAAAGATCTTCTACCTGATCCGCCCAACAAATGCCAATCTGACT
CTCTTTGAGTGCTGGAGCAGTTCCTCTAATCAGAATGAGATGTTCTTTGGGGACCAGGTGGACAAGTGCTACAAGTGTTCCGTGAAGCAA
GGACAGACACTTTTCATTCCCACAGGGTGGATCCATGCTGTGCTGACGCCTGTGGACTGCCTTGCCTTTGGAGGGAACTTCTTACACAGC
CTTAACATCGAGATGCAGCTCAAAGCCTATGAGATTGAGAAGCGGCTGAGCACAGCAGACCTCTTCAGATTCCCCAACTTTGAGACCATC
TGTTGGTATGTGGGAAAGCACATCCTGGACATCTTTCGCGGTTTGCGAGAGAACAGGAGACACCCTGCCTCCTACCTGGTCCATGGTGGC
AAAGCCTTGAACTTGGCCTTTAGAGCCTGGACAAGGAAAGAAGCTCTGCCAGACCATGAGGATGAGATCCCGGAGACAGTGCGAACCGTA
CAGCTCATTAAAGATCTGGCCAGGGAGATCCGCCTGGTGGAAGACATCTTCCAACAGAACGTTGGGAAGACGAGCAATATCTTTGGGCTG
CAGAGGATCTTCCCAGCCGGCTCCATTCCCCTAACCAGGCCAGCCCATTCCACTTCAGTGTCCATGTCCAGGCTGTCACTGCCCTCCAAA
AATGGTTCAAAGAAGAAAGGCCTGAAGCCCAAGGAACTCTTCAAGAAGGCAGAGCGAAAGGGCAAGGAGAGTTCAGCCTTGGGGCCTGCT
GGCCAGTTGAGCTATAATCTCATGGACACATACAGTCATCAGGCACTGAAGACAGGCTCTTTCCAGAAAGCAAAGTTCAACATCACTGGT
GCCTGCTTGAATGACTCAGATGACGACTCACCAGACTTGGACCTTGATGGAAATGAGAGCCCATTGGCCCTATTGATGTCTAACGGCAGT
ACGAAAAGGGTGAAGAGTTTATCCAAATCTCGGCGAACCAAGATAGCAAAGAAGGTAGACAAGGCTAGGCTGATGGCAGAACAGGTGATG
GAAGACGAATTTGACTTGGATTCAGATGATGAGCTGCAGATTGACGAGAGATTGGGAAAGGAGAAGGCGACCCTGATAATAAGACCAAAA
TTTCCCCGGAAATTGCCCCGTGCGAAGCCTTGCTCTGACCCCAACCGAGTTCGTGAACCAGGAGAAGTTGAGTTTGACATTGAGGAGGAC
TATACAACAGATGAGGACATGGTGGAAGGGGTTGAAGGCAAGCTTGGGAATGGTAGTGGCGCTGGTGGCATTCTTGATCTGCTCAAGGCC
AGCAGGCAGGTGGGGGGACCTGACTATGCTGCCCTCACCGAGGCCCCAGCTTCTCCCAGCACTCAGGAGGCCATCCAGGGCATGCTGTGC
ATGGCCAACCTGCAGTCCTCATCGTCCTCACCGGCTACCTCTAGCCTGCAGGCCTGGTGGACTGGGGGACAGGATCGAAGCAGTGGGAGC
TCCAGCAGTGGGCTGGGCACAGTGTCTAACAGTCCTGCTTCCCAGCGCACCCCAGGGAAGCGGCCCATCAAGCGGCCAGCATACTGGAGA
ACCGAGAGCGAGGAGGAGGAGGAGAACGCCAGTCTGGATGAACAGGACAGCTTGGGAGCGTGCTTCAAGGATGCAGAGTATATCTATCCT
TCACTGGAGTCTGATGATGATGACCCTGCTTTGAAATCTCGACCCAAGAAAAAGAAGAATTCAGATGATGCTCCATGGAGTCCTAAAGCC
CGCGTGACCCCAACTCTGCCGAAGCAGGACCGTCCTGTGCGTGAGGGGACCCGGGTAGCCTCTATTGAGACAGGTTTGGCTGCAGCAGCT
GCAAAGCTGGCCCAGCAGGAGCTACAGAAGGCCCAAAAGAAGAAATATATCAAGAAGAAGCCTTTGCTGAAGGAGGTAGAACAGCCTCGC
CCTCAAGACTCCAATCTCAGTCTGACAGTACCAGCCCCCACTGTGGCTGCCACACCACAACTTGTCACCTCCTCCTCACCCCTGCCTCCT
CCTGAGCCTAAACAAGAGGCCCTGTCAGGAAGTCTCGCTGACCATGAGTACACCGCTCGTCCCAATGCCTTTGGCATGGCCCAGGCAAAC
CGCAGCACCACACCTATGGCCCCCGGTGTCTTCTTGACCCAGCGGCGCCCTTCAGTTGGCTCCCAGAGCAATCAGGCAGGACAAGGAAAG
CGTCCCAAAAAGGGCCTGGCCACAGCAAAGCAGAGACTCGGCCGTATCCTGAAAATCCACAGAAATGGCAAACTACTTCTGTGAGCCCTC
CTGTGTCCCACCCCTCACCCCTTTACCCCCATTGCCTTCTCCATTGTCAACTCTTGGGGCACTCCTGGATCCTATCTGCCCTGGACAAGG
TGCTGAGGTGCATTGTCCTGCTTTCTTGGGACTTACCAAAGGCACGGACCCCTCCACCGACTCCTTCTAGTTCCCTTCCCCACTTTCACT
AGAGCATCCTGCCTGCCTTCTCCACTGAGGAGCAGGTAAATGGGAGAGGTTTCCAGCTGACTAGAACCCTCTTTTCTACTCGTCCAAACC
ACTCCCGTCACCTGCCTTGTCTGTTCTTTATTCTTCATCCCCCGCTAGAGCTGGAAGGCAGGATGAGGAGAGGTATGAAGGAGCCTGAGC
CATGAAGTGGGAAGCCCAGTGCTTGACACTTTCTGCAACTCTAGCCCTATATCCAGAAGCCTGCCCACCTCCACCCATTCTGTTTGCCCC
ATTTCCCCAGTCCAGTGGACATGCCCCACCTCCAGACTTGCTCATGGGAGAAGGCTGTGGTCTCTGCCCCCTCTTGCCAAATGCTTCATG
GAAATGAAGAGGAAGGCCTAGAGCCTCCTTCCTGCCCCACTGTGGGCCATTTCCAGAAGTGGCCTAGAAATGCCAACTTCACTTACCTTT
CAAAAGAAAGGTGATTCCTATCACTTGTCAAGGTAGGGAGAGGTCAGATGCCCAAGCCTTTGACCACGGTTTTGTAGCCTGTTGGAGGAA
GCTACTTTTAGCTGGCTACACATGAGGCCACTTGTTTTAGGGTGAGCTCCAGGGATTTGCCTGGATTTTGAAATCATGTAGAACATTATC
CACGTGGCTGTGGCTGTGGCTGTGGCTGGGCCCTGGCAGGTGGAAAACCATCTCCCAGAAACCTGAAAGCACCTGCCAATGACGCAGATA
ACCCTGGCCCTACAGCCTGCTTGCTCCGCCTATACCACAGAGCACAGCCTGGACATTATGGAGGGTGTGGCGGGACGGCCCACACCTGGG
TCCTCCATCGGGAACTTTTCATGCTTCTTTCTCCACCTGAGGTCTTGGTCTGAAGAAGACCTCAGGACTCACATCTTCACTCCTGGGCCT
TTGCACTTCCAGACGACAGGTCATCGTTCAAGCAGAATGCAGACAGGCCATTCACGAGCCCAAGTTGAAGAGAAGAGACGCCCATCCGTG
AAGGAGCAGACCATCCATCCGATCCTCCCCTTCCCCTGTCCTTCCTTCGTGGATTGTCTCCATTGTCCAGACAGTGCCCCCACCTCCCAC
CGCCTTGCCTCACTGGCAATCTGGACTCGATGGAGAACATCCCCCCACCTCCATTTGGCACTACCCAAGTGGAGTGTACCCTTGCCCTTT
CCACCTGTACCACCCACTCCAACCTCACCCCAGCTTGCCCAATGCTTCTGGGGAATTTAATAGCTACCATGCAGGCCACAGGGAATTTGT
GAGGCTTCTTTTGTCATCTTTGTATCTCCAGTTTGTCTTTCTTTTCTCCATAGCCCTGCCTCTACTTTCCTTCCTTGGAATCAGGGGTTC
CTTTAGCCCATTTGCTTTCTCTACCTTGGGGACCCCAGGGGCCAAGCAGTTCTCCATCTAGTCACACCAAAGGCAAAAAGCCTGGCTACC
TCCCCCCTAGCACGTGAGTCCCTACTCCCCTCCCCTCTGTTTCTGCCCAGCTTTGCTTATTTTGGGGATTTCAAGGCAGCAGAGGGTAGT
GAGGGGAGAGCAGGAGAAGCCTCTGTCCTGTATAGGCAACTGCCTGACTATGCGGTGACTGCTGTAACCAAGATCAGGTCCCCAGCCCTT
TTGTCCATTAACACCCCTTCTTGATCTTTCAAAGGCAGCTAATTGCTAGCAAATCCCCCCGATTCCGGCCTTTTCCCTCTATTTCTTTGT
TAGAAGTTTTCTGTGGAGCTGAAACCCAGCCTCTGTTTGACTGGGTTTCATTTAGCTTAGTTGGGTTCTTAGAGCCCCCTGTTTGTTGTT
TTGTGTTGTTTCCAATGAAAAGCAAGTTTACCCTCAGAGTTATGCTTTTCCAAAGAGGCTGATGTCTTTGTTTTTGTTTTTTTTAATGTT
TCAGGTTCTAAGTGAAGTGAGTTGGGGAGGGGTTGGGAGTGTTAGTAATCAAGGTTTAGAACACCATGAGATAGTTACCCCTGATCTCCA
GTCCCTAGCTGGGGGCTGGACAGGGGGAAGGGAGAGAGGATTTCTATTCACCTTTAATATATTTTTACAAAAAAAGCAAACAATTTAAAA
ACAAGCCCACCGCTTCTGTACATGTCTAAATATATTTTTAGAAGTGGGTAGGATTGTGAATTTCTGATGCAGGGCCTTTTTATAAATAGG
TTAGGGTAGCATCATTCAGACTTCTCTGTTGTTTTTGTCCCTGTCTTTTTCTTATGTTGTGTTACTAATGTAATTTATATTTTTTTTAGA

>38113_38113_4_HUWE1-PHF8_HUWE1_chrX_53635813_ENST00000342160_PHF8_chrX_54049276_ENST00000357988_length(amino acids)=1089AA_BP=98
MQRLPSSSYLKKSVILEGTPNTSVRSHQSRRQMALPLLLPQGLIMPQKKPLVRMRRKRKYRPCRALILPSKMKLSLISRLLVQRNVFLFP
SWITSLMCCVGVEEEKAADIDLYHCPNCEVLHGPSIMKKRRGSSKGHDTHKGKPVKTGSPTFVRELRSRTFDSSDEVILKPTGNQLTVEF
LEENSFSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLVE
TPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGD
QVDKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYVGKHILDIFRGLREN
RRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEIPETVRTVQLIKDLAREIRLVEDIFQQNVGKTSNIFGLQRIFPAGSIPLTRPAHST
SVSMSRLSLPSKNGSKKKGLKPKELFKKAERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQKAKFNITGACLNDSDDDSPDLDLDGN
ESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKARLMAEQVMEDEFDLDSDDELQIDERLGKEKATLIIRPKFPRKLPRAKPCSDPNRVR
EPGEVEFDIEEDYTTDEDMVEGVEGKLGNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPATSSLQA
WWTGGQDRSSGSSSSGLGTVSNSPASQRTPGKRPIKRPAYWRTESEEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKK
KNSDDAPWSPKARVTPTLPKQDRPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLLKEVEQPRPQDSNLSLTVPAPTVAAT
PQLVTSSSPLPPPEPKQEALSGSLADHEYTARPNAFGMAQANRSTTPMAPGVFLTQRRPSVGSQSNQAGQGKRPKKGLATAKQRLGRILK

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Fusion Gene PPI Analysis for HUWE1-PHF8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HUWE1-PHF8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HUWE1-PHF8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource