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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HUWE1-WNK1 (FusionGDB2 ID:38120)

Fusion Gene Summary for HUWE1-WNK1

check button Fusion gene summary
Fusion gene informationFusion gene name: HUWE1-WNK1
Fusion gene ID: 38120
HgeneTgene
Gene symbol

HUWE1

WNK1

Gene ID

10075

65125

Gene nameHECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1WNK lysine deficient protein kinase 1
SynonymsARF-BP1|HECTH9|HSPC272|Ib772|LASU1|MRXST|MULE|URE-B1|UREB1HSAN2|HSN2|KDP|PPP1R167|PRKWNK1|PSK|p65
Cytomap

Xp11.22

12p13.33

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase HUWE1ARF-binding protein 1BJ-HCC-24 tumor antigenHECT domain protein LASU1HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligaseHECT-type E3 ubiquitin transferase HUWE1Mcl-1 ubiquitin ligase E3URE-binding proserine/threonine-protein kinase WNK1WNK lysine deficient protein kinase 1 isoformerythrocyte 65 kDa proteinprostate-derived sterile 20-like kinaseprotein kinase with no lysine 1protein phosphatase 1, regulatory subunit 167serine/threonine-protein ki
Modification date2020031320200327
UniProtAcc

Q7Z6Z7

.
Ensembl transtripts involved in fusion geneENST00000218328, ENST00000262854, 
ENST00000342160, ENST00000474288, 
ENST00000340908, ENST00000447667, 
ENST00000530271, ENST00000540360, 
ENST00000574564, ENST00000315939, 
ENST00000535572, ENST00000537687, 
Fusion gene scores* DoF score17 X 22 X 7=261813 X 15 X 6=1170
# samples 2214
** MAII scorelog2(22/2618*10)=-3.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1170*10)=-3.0630097975258
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HUWE1 [Title/Abstract] AND WNK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHUWE1(53619357)-WNK1(992560), # samples:1
Anticipated loss of major functional domain due to fusion event.HUWE1-WNK1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
HUWE1-WNK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HUWE1-WNK1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
HUWE1-WNK1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HUWE1-WNK1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHUWE1

GO:0000209

protein polyubiquitination

15989957

HgeneHUWE1

GO:0006513

protein monoubiquitination

19713937

HgeneHUWE1

GO:0016574

histone ubiquitination

15767685

HgeneHUWE1

GO:0031398

positive regulation of protein ubiquitination

20534529

HgeneHUWE1

GO:0098779

positive regulation of mitophagy in response to mitochondrial depolarization

30217973

TgeneWNK1

GO:0006468

protein phosphorylation

10660600

TgeneWNK1

GO:0010923

negative regulation of phosphatase activity

19389623

TgeneWNK1

GO:0023016

signal transduction by trans-phosphorylation

16669787

TgeneWNK1

GO:0035556

intracellular signal transduction

10660600


check buttonFusion gene breakpoints across HUWE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WNK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-B7-A5TNHUWE1chrX

53619357

-WNK1chr12

992560

+


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Fusion Gene ORF analysis for HUWE1-WNK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000218328ENST00000340908HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000218328ENST00000447667HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000218328ENST00000530271HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000218328ENST00000540360HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000218328ENST00000574564HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000262854ENST00000340908HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000262854ENST00000447667HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000262854ENST00000530271HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000262854ENST00000540360HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000262854ENST00000574564HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000342160ENST00000340908HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000342160ENST00000447667HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000342160ENST00000530271HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000342160ENST00000540360HUWE1chrX

53619357

-WNK1chr12

992560

+
5CDS-intronENST00000342160ENST00000574564HUWE1chrX

53619357

-WNK1chr12

992560

+
Frame-shiftENST00000342160ENST00000315939HUWE1chrX

53619357

-WNK1chr12

992560

+
Frame-shiftENST00000342160ENST00000535572HUWE1chrX

53619357

-WNK1chr12

992560

+
Frame-shiftENST00000342160ENST00000537687HUWE1chrX

53619357

-WNK1chr12

992560

+
In-frameENST00000218328ENST00000315939HUWE1chrX

53619357

-WNK1chr12

992560

+
In-frameENST00000218328ENST00000535572HUWE1chrX

53619357

-WNK1chr12

992560

+
In-frameENST00000218328ENST00000537687HUWE1chrX

53619357

-WNK1chr12

992560

+
In-frameENST00000262854ENST00000315939HUWE1chrX

53619357

-WNK1chr12

992560

+
In-frameENST00000262854ENST00000535572HUWE1chrX

53619357

-WNK1chr12

992560

+
In-frameENST00000262854ENST00000537687HUWE1chrX

53619357

-WNK1chr12

992560

+
intron-3CDSENST00000474288ENST00000315939HUWE1chrX

53619357

-WNK1chr12

992560

+
intron-3CDSENST00000474288ENST00000535572HUWE1chrX

53619357

-WNK1chr12

992560

+
intron-3CDSENST00000474288ENST00000537687HUWE1chrX

53619357

-WNK1chr12

992560

+
intron-intronENST00000474288ENST00000340908HUWE1chrX

53619357

-WNK1chr12

992560

+
intron-intronENST00000474288ENST00000447667HUWE1chrX

53619357

-WNK1chr12

992560

+
intron-intronENST00000474288ENST00000530271HUWE1chrX

53619357

-WNK1chr12

992560

+
intron-intronENST00000474288ENST00000540360HUWE1chrX

53619357

-WNK1chr12

992560

+
intron-intronENST00000474288ENST00000574564HUWE1chrX

53619357

-WNK1chr12

992560

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262854HUWE1chrX53619357-ENST00000535572WNK1chr12992560+10539437438780302547
ENST00000262854HUWE1chrX53619357-ENST00000537687WNK1chr12992560+10694437438780332548
ENST00000262854HUWE1chrX53619357-ENST00000315939WNK1chr12992560+10694437438780332548
ENST00000218328HUWE1chrX53619357-ENST00000535572WNK1chr12992560+10539437438780302547
ENST00000218328HUWE1chrX53619357-ENST00000537687WNK1chr12992560+10694437438780332548
ENST00000218328HUWE1chrX53619357-ENST00000315939WNK1chr12992560+10694437438780332548

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262854ENST00000535572HUWE1chrX53619357-WNK1chr12992560+0.0022885970.9977114
ENST00000262854ENST00000537687HUWE1chrX53619357-WNK1chr12992560+0.0021675260.9978325
ENST00000262854ENST00000315939HUWE1chrX53619357-WNK1chr12992560+0.0021675260.9978325
ENST00000218328ENST00000535572HUWE1chrX53619357-WNK1chr12992560+0.0022885970.9977114
ENST00000218328ENST00000537687HUWE1chrX53619357-WNK1chr12992560+0.0021675260.9978325
ENST00000218328ENST00000315939HUWE1chrX53619357-WNK1chr12992560+0.0021675260.9978325

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Fusion Genomic Features for HUWE1-WNK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HUWE1chrX53619357-WNK1chr12992560+3.76E-060.9999962
HUWE1chrX53619357-WNK1chr12992560+3.76E-060.9999962

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HUWE1-WNK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:53619357/chr12:992560)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HUWE1

Q7Z6Z7

.
FUNCTION: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15989957, PubMed:19713937, PubMed:15567145, PubMed:15767685, PubMed:18488021, PubMed:17567951, PubMed:19037095, PubMed:20534529). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). {ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWNK1chrX:53619357chr12:992560ENST0000057456401221_4790435.0DomainProtein kinase
TgeneWNK1chrX:53619357chr12:992560ENST0000057456401301_3040435.0Nucleotide bindingATP
TgeneWNK1chrX:53619357chr12:992560ENST0000057456401488_5550435.0RegionAutoinhibitory domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHUWE1chrX:53619357chr12:992560ENST00000262854-33842295_246913244375.0Compositional biasNote=Glu-rich
HgeneHUWE1chrX:53619357chr12:992560ENST00000262854-33842427_249013244375.0Compositional biasNote=Asp-rich
HgeneHUWE1chrX:53619357chr12:992560ENST00000262854-33843483_355013244375.0Compositional biasNote=Thr-rich
HgeneHUWE1chrX:53619357chr12:992560ENST00000342160-32832295_246913244375.0Compositional biasNote=Glu-rich
HgeneHUWE1chrX:53619357chr12:992560ENST00000342160-32832427_249013244375.0Compositional biasNote=Asp-rich
HgeneHUWE1chrX:53619357chr12:992560ENST00000342160-32833483_355013244375.0Compositional biasNote=Thr-rich
HgeneHUWE1chrX:53619357chr12:992560ENST00000262854-33841316_135513244375.0DomainUBA
HgeneHUWE1chrX:53619357chr12:992560ENST00000262854-33841370_138913244375.0DomainUIM
HgeneHUWE1chrX:53619357chr12:992560ENST00000262854-33841603_168013244375.0DomainWWE
HgeneHUWE1chrX:53619357chr12:992560ENST00000262854-33844038_437413244375.0DomainHECT
HgeneHUWE1chrX:53619357chr12:992560ENST00000342160-32831316_135513244375.0DomainUBA
HgeneHUWE1chrX:53619357chr12:992560ENST00000342160-32831370_138913244375.0DomainUIM
HgeneHUWE1chrX:53619357chr12:992560ENST00000342160-32831603_168013244375.0DomainWWE
HgeneHUWE1chrX:53619357chr12:992560ENST00000342160-32834038_437413244375.0DomainHECT
TgeneWNK1chrX:53619357chr12:992560ENST000003159391428221_47911632383.0DomainProtein kinase
TgeneWNK1chrX:53619357chr12:992560ENST000003409081125221_4797561976.0DomainProtein kinase
TgeneWNK1chrX:53619357chr12:992560ENST000005376871428221_47914232643.0DomainProtein kinase
TgeneWNK1chrX:53619357chr12:992560ENST000003159391428301_30411632383.0Nucleotide bindingATP
TgeneWNK1chrX:53619357chr12:992560ENST000003409081125301_3047561976.0Nucleotide bindingATP
TgeneWNK1chrX:53619357chr12:992560ENST000005376871428301_30414232643.0Nucleotide bindingATP
TgeneWNK1chrX:53619357chr12:992560ENST000003159391428488_55511632383.0RegionAutoinhibitory domain
TgeneWNK1chrX:53619357chr12:992560ENST000003409081125488_5557561976.0RegionAutoinhibitory domain
TgeneWNK1chrX:53619357chr12:992560ENST000005376871428488_55514232643.0RegionAutoinhibitory domain


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Fusion Gene Sequence for HUWE1-WNK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>38120_38120_1_HUWE1-WNK1_HUWE1_chrX_53619357_ENST00000218328_WNK1_chr12_992560_ENST00000315939_length(transcript)=10694nt_BP=4374nt
GAGGCTTTCGACTGAGGGCTAGCGAGGGGAGCACGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGAAGCAGG
GCCGCGGACCCCGCACGCTCCTGCGGGCCCCGCGGAGCCATTGCGGCCGAGGCCTCGGCAGGCGCCAGCGGAGAGCTAGCCGCATCTTCG
GGGGCAGCCCGGCAGCTGCCGGCGGCGCGGCGAGAGAGCGGCTGACAGAGGGGATGCGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTA
GTGATCCAGAGAAACCAGCAGGCCAACTTGGTCAGGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTAT
GATTGGCTGTGATTTTAGATCGTAAAGCTGAAAATTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCT
GCAGACTGCAGAGCCTTAATAGACAAACTCAAAGTTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATT
GGAAAGTGCGAGTTATATCACTGGGTGGACCTGTTGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCA
TGGATGCTCGTATGTGATAGGCCAGAAAGAGAGCAACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTAC
AGCTTTTCCCGGCATCTGTACAGTTCCATAGAGCATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAAT
CTCCTATATGTATTTAGCAAAAGATCAAACTACATCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTG
GCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACT
ACACTACACTTTGAATTCTATGCAGATCCTGGGGCCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATA
GAGCAACTTGACAAGATTTCAGAAAGCCCTTCTGAAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTG
TTATTTACACACATACGACTGGCCCATGGCTTTTCTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATA
TTAGTGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACG
GATAAGCAGCTTATGGAGATTAAAGCAGCTTCTTTACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATT
ATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGAT
CCATACCCTCACCAGTTTGCCACTGCTCTCTTCTCTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGT
GGAATGATGGAAGCCTTATTGAAGGTCATAAAGTTTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTT
GACCTTATCACCAACCTGGATATGGCAGCTTTTCAATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTG
TGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGAT
GGAGTCCAGTGTATTCCACAACGAGCAGCACTTCTGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGAT
GGCATACGACATGTGATGGATGGTTCTCTGCCTACCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTC
CTAGCTACTGAAGTGGTGACTGTGTTTGTATTTCAAGAACCATCACTGCTCTCCTCACTCCAGGACAATGGATTGACAGATGTCATGCTG
CATGCACTGCTTATCAAAGATGTTCCTGCTACCCGTGAAGTCCTTGGCTCCCTCCCAAATGTATTCAGTGCACTCTGTTTGAATGCCCGA
GGTCTTCAGTCTTTTGTTCAGTGTCAGCCTTTTGAACGCCTCTTCAAAGTTCTTCTGTCTCCAGATTACCTCCCAGCCATGCGGAGGAGG
AGAAGTTCTGATCCCCTTGGGGATACTGCATCCAACCTGGGGAGTGCTGTCGATGAGCTCATGAGACATCAGCCCACCCTTAAAACAGAT
GCAACGACTGCCATCATCAAGTTACTTGAAGAAATCTGTAATCTTGGAAGGGACCCCAAATACATCTGTCAGAAGCCATCAATCCAGAAG
GCAGATGGCACTGCCACTGCTCCTCCCCCAAGGTCTAATCATGCCGCAGAAGAAGCCTCTAGTGAGGATGAGGAGGAAGAGGAAGTACAG
GCCATGCAGAGCTTTAATTCTACCCAGCAAAATGAAACTGAGCCTAATCAGCAGGTTGTTGGTACAGAGGAACGTATTCCTATTCCCCTC
ATGGATTACATCCTTAATGTGATGAAATTTGTGGAATCTATTCTGAGCAACAATACAACAGATGACCACTGCCAGGAATTTGTGAATCAG
AAAGGACTGTTGCCTTTGGTTACCATTTTGGGTCTTCCCAATCTGCCCATTGACTTTCCCACATCTGCTGCCTGTCAGGCTGTTGCAGGT
GTCTGCAAATCCATATTGACACTGTCACATGAACCCAAAGTCCTTCAAGAGGGTCTCCTTCAGTTGGACTCCATCCTCTCCTCCCTGGAG
CCCTTACACCGCCCCATTGAATCCCCTGGGGGCTCAGTGTTGTTGCGAGAACTGGCTTGCGCAGGCAATGTTGCTGATGCTACCCTCTCA
GCCCAGGCCACACCTCTGCTGCATGCACTCACTGCTGCCCATGCCTACATCATGATGTTTGTTCATACTTGCAGAGTTGGACAGAGTGAA
ATTCGTTCCATCTCCGTAAACCAGTGGGGCTCTCAATTGGGTCTGAGTGTTTTGAGCAAGCTGAGCCAGTTATACTGTTCCCTGGTGTGG
GAAAGCACTGTCCTCCTCTCTCTGTGTACCCCAAACAGCCTACCATCTGGGTGTGAATTTGGCCAGGCAGATATGCAGAAACTGGTTCCA
AAGGATGAGAAGGCAGGTACGACCCAGGGCGGAAAAAGATCAGATGGGGAACAGGATGGAGCAGCTGGAAGTATGGATGCTTCTACCCAG
GGCTTATTAGAAGGCATTGGGCTAGATGGTGACACATTGGCTCCCATGGAGACAGATGAACCTACTGCTTCAGACTCTAAGGGCAAATCT
AAAATCACACCAGCAATGGCTGCCAGAATTAAGCAAATCAAGCCTTTGTTATCAGCTTCCTCCAGATTAGGCCGAGCACTTGCTGAGCTA
TTTGGACTTCTTGTTAAACTTTGTGTGGGATCTCCTGTCCGCCAGAGAAGGAGCCATCATGCTGCCAGCACCACTACAGCACCGACACCT
GCCGCGCGATCAACAGCCTCAGCTCTCACTAAGCTCTTGACTAAGGGGTTATCTTGGCAGCCCCCACCATATACACCTACTCCCCGATTC
AGGCTGACATTCTTCATCTGTTCAGTTGGTTTCACATCCCCAATGCTGTTTGATGAGAGGAAGTATCCCTACCACCTCATGCTGCAAAAA
TTTCTCTGCTCCGGAGGCCACAATGCTCTTTTTGAAACTTTCAACTGGGCTCTGTCCATGGGAGGTAAAGTTCCTGTTTCTGAGGGATTG
GAACACTCAGACTTGCCTGATGGCACAGGAGAATTCCTAGATGCCTGGCTTATGCTGGTGGAGAAGATGGTGAATCCCACCACGGTGCTT
GAATCTCCACATTCGCTGCCTGCCAAATTGCCTGGAGGTGTCCAGAACTTTCCCCAGTTCAGTGCACTGCGCTTCCTTGTGGTAACTCAG
AAAGCAGCCTTTACTTGCATCAAAAACTTATGGAACCGGAAACCCCTGAAGGTATATGGTGGACGAATGGCTGAATCGATGCTGGCCATT
CTATGCCACATCCTCCGAGGAGAACCTGTGATTCGAGAGAGACTAAGCAAGGAGAAGGAGGGGTCTCGAGGAGAAGAGGATACAGGGCAA
GAGGAAGGTGGCTCCCGCCGGGAACCTCAAGTCAACCAGCAACAACTGCAACAGGTGAACAATGACTTTATTCTAGCAATAGAGAGAGAG
TCGTTTGTGGATCAAGTGCGAGAAATTATTGAAAAAGCTGATGAAATGCTCAGTGAGGATGTCAGTGTGGAACCAGAGGGTGATCAGGGA
TTGGAGAGTCTACAAGGAAAGGATGACTATGGCTTTTCAGGTTCTCAGAAATTGGAAGGAGAGTTCAAACAACCAATTCCTGCGTCTTCC
ATGCCACAGCAAATAGGCATTCCTACCAGTTCTTTAACTCAAGTTGTTCATTCTGCGGGAAGGCGGTTTATAGTGAGTCCTGTGCCAGAA
AGCCGATTACGAGAATCAAAAGTTTTCCCCAGTGAAATAACAGATACAGTTGCTGCCTCTACAGCTCAGAGCCCTGGAATGAACTTGTCT
CACTCTGCATCATCCCTTAGTCTACAACAGGCCTTTTCTGAACTTAGACGTGCCCAAATGACAGAAGGACCCAACACAGCACCTCCAAAC
TTTAGTCATACAGGACCAACATTTCCAGTAGTACCTCCTTTCTTAAGTAGCATTGCTGGAGTCCCAACCACAGCAGCAGCCACAGCACCA
GTCCCTGCAACAAGCAGCCCTCCTAATGACATTTCCACATCAGTAATTCAGTCTGAGGTTACAGTGCCCACTGAAGAGGGGATTGCTGGA
GTTGCCACCAGCACAGGTGTGGTAACTTCAGGTGGTCTCCCCATACCACCTGTGTCTGAATCACCAGTACTTTCCAGCGTAGTTTCAAGT
ATCACAATACCTGCAGTTGTCTCAATATCTACTACATCCCCGTCACTTCAAGTCCCCACATCCACATCTGAGATCGTTGTTTCTAGTACA
GCACTGTATCCTTCAGTAACAGTTTCAGCAACTTCAGCCTCTGCAGGGGGCAGTACTGCTACCCCAGGTCCTAAGCCTCCAGCTGTAGTA
TCTCAGCAGGCAGCAGGCAGCACTACTGTGGGAGCCACATTAACATCAGTTTCTACCACCACTTCATTCCCAAGCACAGCTTCACAGCTG
TGCATTCAGCTTAGCAGCAGTACTTCTACTCCTACTTTAGCTGAAACCGTGGTAGTTAGCGCACACTCACTAGATAAGACATCTCATAGC
AGTACAACTGGATTGGCTTTCTCCCTCTCTGCACCATCTTCCTCTTCCTCTCCTGGAGCAGGAGTGTCTAGTTATATTTCTCAGCCTGGT
GGGCTGCATCCTTTGGTCATTCCATCAGTGATAGCTTCTACTCCTATTCTTCCCCAAGCAGCAGGACCTACTTCTACACCTTTATTACCC
CAAGTACCTAGTATCCCACCCTTGGTACAGCCTGTTGCCAATGTGCCTGCTGTACAGCAGACACTAATTCATAGTCAGCCTCAACCAGCT
TTGCTTCCCAACCAGCCCCATACTCATTGTCCTGAAGTAGATTCTGATACACAACCCAAAGCTCCTGGAATTGATGACATAAAGACTCTA
GAAGAAAAGCTGCGGTCTCTGTTCAGTGAACACAGCTCATCTGGAGCTCAGCATGCCTCTGTCTCACTGGAGACCTCACTAGTCATAGAG
AGCACTGTCACACCAGGCATCCCAACTACTGCTGTTGCACCAAGCAAACTCCTGACTTCTACCACAAGTACTTGCTTACCACCAACCAAT
TTACCACTAGGAACAGTTGCTTTGCCAGTTACACCAGTGGTCACACCTGGGCAAGTTTCTACCCCAGTCAGCACTACTACATCAGGAGTG
AAACCTGGAACTGCTCCCTCCAAGCCACCTCTAACTAAGGCTCCGGTGCTGCCAGTGGGTACTGAACTTCCAGCAGGTACTCTACCCAGC
GAGCAGCTGCCACCTTTTCCAGGACCTTCTCTAACCCAGTCCCAGCAACCTCTAGAGGATCTTGATGCTCAATTGAGAAGAACACTTAGT
CCAGAGATGATCACAGTGACTTCTGCGGTTGGTCCTGTGTCCATGGCGGCTCCAACAGCAATCACAGAAGCAGGAACACAGCCTCAGAAG
GGTGTTTCTCAAGTCAAAGAAGGCCCTGTCCTAGCAACTAGTTCAGGAGCTGGTGTTTTTAAGATGGGACGATTTCAGGTTTCTGTTGCA
GCAGACGGTGCCCAGAAAGAGGGTAAAAATAAGTCAGAAGATGCAAAGTCTGTTCATTTTGAATCCAGCACCTCAGAGTCCTCAGTGCTA
TCAAGTAGTAGTCCAGAGAGTACCTTGGTGAAACCAGAGCCGAATGGCATAACCATCCCTGGTATCTCTTCAGATGTGCCAGAGAGTGCC
CACAAAACTACTGCCTCAGAGGCAAAGTCAGACACTGGGCAGCCTACCAAGGTTGGACGTTTTCAGGTGACAACTACAGCAAACAAAGTG
GGTCGTTTCTCTGTATCAAAAACTGAGGACAAGATCACTGACACAAAGAAAGAAGGACCAGTGGCATCTCCTCCTTTTATGGATTTGGAA
CAAGCTGTTCTTCCTGCTGTGATACCAAAGAAAGAGAAGCCTGAACTGTCAGAGCCTTCACATCTAAATGGGCCGTCTTCTGACCCGGAG
GCCGCTTTTTTAAGTAGGGATGTGGATGATGGTTCCGGTAGTCCACACTCGCCCCATCAGCTGAGCTCAAAGAGCCTTCCTAGCCAGAAT
CTAAGTCAAAGCCTTAGTAATTCATTTAACTCCTCTTACATGAGTAGCGACAATGAGTCAGATATCGAAGATGAAGACTTAAAGTTAGAG
CTGCGACGACTACGAGATAAACATCTCAAAGAGATTCAGGACCTGCAGAGTCGCCAGAAGCATGAAATTGAATCTTTGTATACCAAACTG
GGCAAGGTGCCCCCTGCTGTTATTATTCCCCCAGCTGCTCCCCTTTCAGGGAGAAGACGACGACCCACTAAAAGCAAAGGCAGCAAATCT
AGTCGAAGCAGTTCCTTGGGGAATAAAAGCCCCCAGCTTTCAGGTAACCTGTCTGGTCAGAGTGCAGCTTCAGTCTTGCACCCCCAGCAG
ACCCTCCACCCTCCTGGCAACATCCCAGAGTCCGGGCAGAATCAGCTGTTACAGCCCCTTAAGCCATCTCCCTCCAGTGACAACCTCTAT
TCAGCCTTCACCAGTGATGGTGCCATTTCAGTACCAAGCCTTTCTGCTCCAGGTCAAGGAACCAGCAGCACAAACACTGTTGGGGCAACA
GTGAACAGCCAAGCCGCCCAAGCTCAGCCTCCTGCCATGACGTCCAGCAGGAAGGGCACATTCACAGATGACTTGCACAAGTTGGTAGAC
AATTGGGCCCGAGATGCCATGAATCTCTCAGGCAGGAGAGGAAGCAAAGGGCACATGAATTACGAGGGCCCTGGAATGGCAAGGAAGTTC
TCTGCACCTGGGCAACTGTGCATCTCCATGACCTCGAACCTGGGTGGCTCTGCCCCCATCTCTGCAGCATCAGCTACCTCTCTAGGTCAC
TTCACCAAGTCTATGTGCCCCCCACAGCAGTATGGCTTTCCAGCTACCCCATTTGGCGCTCAATGGAGTGGGACGGGTGGCCCAGCACCA
CAGCCACTTGGCCAGTTCCAACCTGTGGGAACTGCCTCCTTGCAGAATTTCAACATCAGCAATTTGCAGAAATCCATCAGCAACCCCCCA
GGCTCCAACCTGCGGACCACTTAGACCTAGAGACATTAACTGAATAGATCTGGGGGCAGGAGATGGAATGCTGAGGGGGTGGGTGGGGGT
GGGAAGTAGCCTATATACTAACTACTAGTGCTGCATTTAACTGGTTATTTCTTGCCAGAGGGGAATGTTTTTAATACTGCATTGAGCCCT
CAGAATGGAGAGTCTCCCCCGCTCCAGTTATTGGAATGGGAGAGGAAGGAAAGAACAGCTTTTTTGTCAAGGGGCAGCTTCAGACCATGC
TTTCCTGTTTATCTATACTCAGTAATGAGGATGAGGGCTAGGAAAGTCTTGTTCATAAGGAAGCTGGAGAACTCAATGTAAAATCAAACC
CATCTGTAATTTCGAGTGGGTGGAGCTCTTGCTTTTGGTACATGCCCTGAATCCCTCACTCCCTCAAGAATCCGAACCACAGGACAAAAA
CCACCTACTGGGCTCTCTCCTACCCTGCCCTCCTCCCTTTTTTTTACCCCTCTCTTTTTTATTTTTTCTTTGCTCTTTAGAACCCAGTGA
AAAATACCAGGGTACTGGGGTGCAACTCTTTCTTATGATAGGTCATTAGTGCTTTAAGCAAAAGATATTAGCAGCTTTGACTGCAGCATT
AGCAATTAGGAAAAAAAAAAAATTAAGTTCCCTGCGGACATGTAACTTTGCCATCAGTTTTGATGTGGAAACACTGTGATATATAAAATG
TTGTTGGACAACAGTAGTTTTAAGAGTAAAATATGAAACGTTTAAAAAGTTCCAAAAAAAGCTAGCTCTGTCCTTTACTTATTGAGACAC
TTTAACTTTTTCCTTTGTATTTCCATTGTATTAGATAAATAAATGTGAATGTAAAATTGTATAAATTACTGTACTTGAATACTTCTGTTT
CCCAGTGTTGCTTGCTGGACATTTTAGTGCCTTGGACTTCTATTGCTTCTGCCATTAGCATCAACTTACCAGACCCCAGATCAATAAAGG
GCATGTGGAAGGAAATCGTAGGTCCATGTGACCCCAGCAGTCCAGCAGTGGTTATGCCAAAGGGAAATTGAAAAAGTATTTTTTTAAGTC
ATTCAACAACTTTGTCTAGAGCAGGTGTAAGATGAGTAGGGTGGGAAGTTAGGTTGGCATCAGTGGTTAAAAACAGAAAGTTCTGTTTCG
GGAATAGTGAGGAGGGGGTGTTGTAACAAAATTGGACAACTTAAAAGAATGGTGTGTGCTGGGTGAAAGACAAAGACTAAAGAATGAGGA
AACAAACGTGATGCCTGGCCAGTGACTGTCATATAAACCTTTCTTATTTGAGCTAGGCTTGAACAGACGTGACCTAGAAGAAACTGAACA
TAAAGAGAAGGGGGTGGGGGGCTAGTTTTCAAGTTGGGGAACCTGATAGTGAAAAGTCACAGATGGAGAAAATTGCTCTCAGAAAAACTG
TTTGGATTGCTTTCCTCTTGTTGCACATGTACCATGCATTTCTCAGCTTGGGGTACTACATTTTGTGGAAAGTTAATCTATCTATCTTTC
CACATCTGAATTAATCATTCTAGGAAAGAATACTTATTCCTACTCATTTCCTTTATGATGTCCAAATGGTTGCAGGATCATAATCTATTG
TGCCACCTTTATTTCTAGAAGTACAACTAATATGTTCACATTTTCAAATAAATAATACTCCCCGTAAGTAATAACTGCAACCAATCAGTG
TTATTCAGTGCTATGCCTCCTTGTAATGGGTAGTTATTAATTATTTTCAGAGCTTTCCGGAAATACTGTCCTAACTGGCTATGTTTAGGA
TCTTTGTTATCTCTGAAGACAAAGAAAGAAGCTAGGACTCTTAATTTTGGGGTGCTTCTTGACTCTTAGTTGGGAAACTGAAAATATTTC
CAACCTTTTACCCACGTCAATGGCATATTCTGGGAATCACCACCACCACCACCACTACCACAGAAAGAGGCTGGAGGCTCCTGTACCCTG
TTCATTCCTTAAGGGCCCTGCTTCCCTTAGTAAGTAAGTAAGTTGGTCTACGGCCCTAAATATGCAAATGAGAGCTGAAGGTTTTTAAAA
GGTAGAAAGGAAAAGGGCAAGGGCTTCCACCCCTGCTTTAAAATGATTTATTTATTCTCTGCTTGTATTTCTTGTGGAGAGAGTAAGGAT
AGAACCAACAAGGGGCTGAGTAGCTGAGAAAGGGGCCACCCAAGAGTGAAACATACTTTATACCAGAGGAGCAGTGGAGCCTCATGCAGC
ACATTATCATTTGTTATTTGGGTTTAATAATAATTTTGACATCTTTTCACTCATACACAAAAAAAGTCAGAACTGGTGTTATTTACTGTT
GATTTCATCCTCCTGTGTATGAAATAACAAGCCTAGAGGAATGAACTAGTGCTACTGAACTGTTTAAATTATTTTTGTGTTAATAGTACA
CTTTGAGTATCTTTTTCCACATTAAAAACTTTCTGAATTATAAATGTTTTCCTTACATTATTTAACAATGTACACTGTTAAAAATAAAAA
TAAAAATTCAAACTTTGGGGGTTTCTCAGCAGCCGTTAATTGTACATTTTGCACTAACTCTGGGTGTTGCGCTTCTTGTAAGATTGCGCT

>38120_38120_1_HUWE1-WNK1_HUWE1_chrX_53619357_ENST00000218328_WNK1_chr12_992560_ENST00000315939_length(amino acids)=2548AA_BP=1326
MKIEIMKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPE
REQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKEN
GFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAH
GFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASY
HGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMA
AFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGS
LPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQ
PFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPP
PRSNHAAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTI
LGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHA
LTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQKLVPKDEKAGTTQ
GGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLAPMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCV
GSPVRQRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKYPYHLMLQKFLCSGGHNA
LFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKN
LWNRKPLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQVNNDFILAIERESFVDQVREI
IEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRFIVSPVPESRLRESKVF
PSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSHTGPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPN
DISTSVIQSEVTVPTEEGIAGVATSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSEIVVSSTALYPSVTVS
ATSASAGGSTATPGPKPPAVVSQQAAGSTTVGATLTSVSTTTSFPSTASQLCIQLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSL
SAPSSSSSPGAGVSSYISQPGGLHPLVIPSVIASTPILPQAAGPTSTPLLPQVPSIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTH
CPEVDSDTQPKAPGIDDIKTLEEKLRSLFSEHSSSGAQHASVSLETSLVIESTVTPGIPTTAVAPSKLLTSTTSTCLPPTNLPLGTVALP
VTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPFPGPSLTQSQQPLEDLDAQLRRTLSPEMITVTSA
VGPVSMAAPTAITEAGTQPQKGVSQVKEGPVLATSSGAGVFKMGRFQVSVAADGAQKEGKNKSEDAKSVHFESSTSESSVLSSSSPESTL
VKPEPNGITIPGISSDVPESAHKTTASEAKSDTGQPTKVGRFQVTTTANKVGRFSVSKTEDKITDTKKEGPVASPPFMDLEQAVLPAVIP
KKEKPELSEPSHLNGPSSDPEAAFLSRDVDDGSGSPHSPHQLSSKSLPSQNLSQSLSNSFNSSYMSSDNESDIEDEDLKLELRRLRDKHL
KEIQDLQSRQKHEIESLYTKLGKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQSAASVLHPQQTLHPPGNIP
ESGQNQLLQPLKPSPSSDNLYSAFTSDGAISVPSLSAPGQGTSSTNTVGATVNSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNL
SGRRGSKGHMNYEGPGMARKFSAPGQLCISMTSNLGGSAPISAASATSLGHFTKSMCPPQQYGFPATPFGAQWSGTGGPAPQPLGQFQPV

--------------------------------------------------------------
>38120_38120_2_HUWE1-WNK1_HUWE1_chrX_53619357_ENST00000218328_WNK1_chr12_992560_ENST00000535572_length(transcript)=10539nt_BP=4374nt
GAGGCTTTCGACTGAGGGCTAGCGAGGGGAGCACGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGAAGCAGG
GCCGCGGACCCCGCACGCTCCTGCGGGCCCCGCGGAGCCATTGCGGCCGAGGCCTCGGCAGGCGCCAGCGGAGAGCTAGCCGCATCTTCG
GGGGCAGCCCGGCAGCTGCCGGCGGCGCGGCGAGAGAGCGGCTGACAGAGGGGATGCGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTA
GTGATCCAGAGAAACCAGCAGGCCAACTTGGTCAGGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTAT
GATTGGCTGTGATTTTAGATCGTAAAGCTGAAAATTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCT
GCAGACTGCAGAGCCTTAATAGACAAACTCAAAGTTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATT
GGAAAGTGCGAGTTATATCACTGGGTGGACCTGTTGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCA
TGGATGCTCGTATGTGATAGGCCAGAAAGAGAGCAACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTAC
AGCTTTTCCCGGCATCTGTACAGTTCCATAGAGCATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAAT
CTCCTATATGTATTTAGCAAAAGATCAAACTACATCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTG
GCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACT
ACACTACACTTTGAATTCTATGCAGATCCTGGGGCCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATA
GAGCAACTTGACAAGATTTCAGAAAGCCCTTCTGAAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTG
TTATTTACACACATACGACTGGCCCATGGCTTTTCTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATA
TTAGTGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACG
GATAAGCAGCTTATGGAGATTAAAGCAGCTTCTTTACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATT
ATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGAT
CCATACCCTCACCAGTTTGCCACTGCTCTCTTCTCTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGT
GGAATGATGGAAGCCTTATTGAAGGTCATAAAGTTTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTT
GACCTTATCACCAACCTGGATATGGCAGCTTTTCAATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTG
TGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGAT
GGAGTCCAGTGTATTCCACAACGAGCAGCACTTCTGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGAT
GGCATACGACATGTGATGGATGGTTCTCTGCCTACCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTC
CTAGCTACTGAAGTGGTGACTGTGTTTGTATTTCAAGAACCATCACTGCTCTCCTCACTCCAGGACAATGGATTGACAGATGTCATGCTG
CATGCACTGCTTATCAAAGATGTTCCTGCTACCCGTGAAGTCCTTGGCTCCCTCCCAAATGTATTCAGTGCACTCTGTTTGAATGCCCGA
GGTCTTCAGTCTTTTGTTCAGTGTCAGCCTTTTGAACGCCTCTTCAAAGTTCTTCTGTCTCCAGATTACCTCCCAGCCATGCGGAGGAGG
AGAAGTTCTGATCCCCTTGGGGATACTGCATCCAACCTGGGGAGTGCTGTCGATGAGCTCATGAGACATCAGCCCACCCTTAAAACAGAT
GCAACGACTGCCATCATCAAGTTACTTGAAGAAATCTGTAATCTTGGAAGGGACCCCAAATACATCTGTCAGAAGCCATCAATCCAGAAG
GCAGATGGCACTGCCACTGCTCCTCCCCCAAGGTCTAATCATGCCGCAGAAGAAGCCTCTAGTGAGGATGAGGAGGAAGAGGAAGTACAG
GCCATGCAGAGCTTTAATTCTACCCAGCAAAATGAAACTGAGCCTAATCAGCAGGTTGTTGGTACAGAGGAACGTATTCCTATTCCCCTC
ATGGATTACATCCTTAATGTGATGAAATTTGTGGAATCTATTCTGAGCAACAATACAACAGATGACCACTGCCAGGAATTTGTGAATCAG
AAAGGACTGTTGCCTTTGGTTACCATTTTGGGTCTTCCCAATCTGCCCATTGACTTTCCCACATCTGCTGCCTGTCAGGCTGTTGCAGGT
GTCTGCAAATCCATATTGACACTGTCACATGAACCCAAAGTCCTTCAAGAGGGTCTCCTTCAGTTGGACTCCATCCTCTCCTCCCTGGAG
CCCTTACACCGCCCCATTGAATCCCCTGGGGGCTCAGTGTTGTTGCGAGAACTGGCTTGCGCAGGCAATGTTGCTGATGCTACCCTCTCA
GCCCAGGCCACACCTCTGCTGCATGCACTCACTGCTGCCCATGCCTACATCATGATGTTTGTTCATACTTGCAGAGTTGGACAGAGTGAA
ATTCGTTCCATCTCCGTAAACCAGTGGGGCTCTCAATTGGGTCTGAGTGTTTTGAGCAAGCTGAGCCAGTTATACTGTTCCCTGGTGTGG
GAAAGCACTGTCCTCCTCTCTCTGTGTACCCCAAACAGCCTACCATCTGGGTGTGAATTTGGCCAGGCAGATATGCAGAAACTGGTTCCA
AAGGATGAGAAGGCAGGTACGACCCAGGGCGGAAAAAGATCAGATGGGGAACAGGATGGAGCAGCTGGAAGTATGGATGCTTCTACCCAG
GGCTTATTAGAAGGCATTGGGCTAGATGGTGACACATTGGCTCCCATGGAGACAGATGAACCTACTGCTTCAGACTCTAAGGGCAAATCT
AAAATCACACCAGCAATGGCTGCCAGAATTAAGCAAATCAAGCCTTTGTTATCAGCTTCCTCCAGATTAGGCCGAGCACTTGCTGAGCTA
TTTGGACTTCTTGTTAAACTTTGTGTGGGATCTCCTGTCCGCCAGAGAAGGAGCCATCATGCTGCCAGCACCACTACAGCACCGACACCT
GCCGCGCGATCAACAGCCTCAGCTCTCACTAAGCTCTTGACTAAGGGGTTATCTTGGCAGCCCCCACCATATACACCTACTCCCCGATTC
AGGCTGACATTCTTCATCTGTTCAGTTGGTTTCACATCCCCAATGCTGTTTGATGAGAGGAAGTATCCCTACCACCTCATGCTGCAAAAA
TTTCTCTGCTCCGGAGGCCACAATGCTCTTTTTGAAACTTTCAACTGGGCTCTGTCCATGGGAGGTAAAGTTCCTGTTTCTGAGGGATTG
GAACACTCAGACTTGCCTGATGGCACAGGAGAATTCCTAGATGCCTGGCTTATGCTGGTGGAGAAGATGGTGAATCCCACCACGGTGCTT
GAATCTCCACATTCGCTGCCTGCCAAATTGCCTGGAGGTGTCCAGAACTTTCCCCAGTTCAGTGCACTGCGCTTCCTTGTGGTAACTCAG
AAAGCAGCCTTTACTTGCATCAAAAACTTATGGAACCGGAAACCCCTGAAGGTATATGGTGGACGAATGGCTGAATCGATGCTGGCCATT
CTATGCCACATCCTCCGAGGAGAACCTGTGATTCGAGAGAGACTAAGCAAGGAGAAGGAGGGGTCTCGAGGAGAAGAGGATACAGGGCAA
GAGGAAGGTGGCTCCCGCCGGGAACCTCAAGTCAACCAGCAACAACTGCAACAGGTGAACAATGACTTTATTCTAGCAATAGAGAGAGAG
TCGTTTGTGGATCAAGTGCGAGAAATTATTGAAAAAGCTGATGAAATGCTCAGTGAGGATGTCAGTGTGGAACCAGAGGGTGATCAGGGA
TTGGAGAGTCTACAAGGAAAGGATGACTATGGCTTTTCAGGTTCTCAGAAATTGGAAGGAGAGTTCAAACAACCAATTCCTGCGTCTTCC
ATGCCACAGCAAATAGGCATTCCTACCAGTTCTTTAACTCAAGTTGTTCATTCTGCGGGAAGGCGGTTTATAGTGAGTCCTGTGCCAGAA
AGCCGATTACGAGAATCAAAAGTTTTCCCCAGTGAAATAACAGATACAGTTGCTGCCTCTACAGCTCAGAGCCCTGGAATGAACTTGTCT
CACTCTGCATCATCCCTTAGTCTACAACAGGCCTTTTCTGAACTTAGACGTGCCCAAATGACAGAAGGACCCAACACAGCACCTCCAAAC
TTTAGTCATACAGGACCAACATTTCCAGTAGTACCTCCTTTCTTAAGTAGCATTGCTGGAGTCCCAACCACAGCAGCAGCCACAGCACCA
GTCCCTGCAACAAGCAGCCCTCCTAATGACATTTCCACATCAGTAATTCAGTCTGAGGTTACAGTGCCCACTGAAGAGGGGATTGCTGGA
GTTGCCACCAGCACAGGTGTGGTAACTTCAGGTGGTCTCCCCATACCACCTGTGTCTGAATCACCAGTACTTTCCAGCGTAGTTTCAAGT
ATCACAATACCTGCAGTTGTCTCAATATCTACTACATCCCCGTCACTTCAAGTCCCCACATCCACATCTGAGATCGTTGTTTCTAGTACA
GCACTGTATCCTTCAGTAACAGTTTCAGCAACTTCAGCCTCTGCAGGGGGCAGTACTGCTACCCCAGGTCCTAAGCCTCCAGCTGTAGTA
TCTCAGCAGGCAGCAGGCAGCACTACTGTGGGAGCCACATTAACATCAGTTTCTACCACCACTTCATTCCCAAGCACAGCTTCACAGCTG
TGCATTCAGCTTAGCAGCAGTACTTCTACTCCTACTTTAGCTGAAACCGTGGTAGTTAGCGCACACTCACTAGATAAGACATCTCATAGC
AGTACAACTGGATTGGCTTTCTCCCTCTCTGCACCATCTTCCTCTTCCTCTCCTGGAGCAGGAGTGTCTAGTTATATTTCTCAGCCTGGT
GGGCTGCATCCTTTGGTCATTCCATCAGTGATAGCTTCTACTCCTATTCTTCCCCAAGCAGCAGGACCTACTTCTACACCTTTATTACCC
CAAGTACCTAGTATCCCACCCTTGGTACAGCCTGTTGCCAATGTGCCTGCTGTACAGCAGACACTAATTCATAGTCAGCCTCAACCAGCT
TTGCTTCCCAACCAGCCCCATACTCATTGTCCTGAAGTAGATTCTGATACACAACCCAAAGCTCCTGGAATTGATGACATAAAGACTCTA
GAAGAAAAGCTGCGGTCTCTGTTCAGTGAACACAGCTCATCTGGAGCTCAGCATGCCTCTGTCTCACTGGAGACCTCACTAGTCATAGAG
AGCACTGTCACACCAGGCATCCCAACTACTGCTGTTGCACCAAGCAAACTCCTGACTTCTACCACAAGTACTTGCTTACCACCAACCAAT
TTACCACTAGGAACAGTTGCTTTGCCAGTTACACCAGTGGTCACACCTGGGCAAGTTTCTACCCCAGTCAGCACTACTACATCAGGAGTG
AAACCTGGAACTGCTCCCTCCAAGCCACCTCTAACTAAGGCTCCGGTGCTGCCAGTGGGTACTGAACTTCCAGCAGGTACTCTACCCAGC
GAGCAGCTGCCACCTTTTCCAGGACCTTCTCTAACCCAGTCCCAGCAACCTCTAGAGGATCTTGATGCTCAATTGAGAAGAACACTTAGT
CCAGAGATGATCACAGTGACTTCTGCGGTTGGTCCTGTGTCCATGGCGGCTCCAACAGCAATCACAGAAGCAGGAACACAGCCTCAGAAG
GTTTCTCAAGTCAAAGAAGGCCCTGTCCTAGCAACTAGTTCAGGAGCTGGTGTTTTTAAGATGGGACGATTTCAGGTTTCTGTTGCAGCA
GACGGTGCCCAGAAAGAGGGTAAAAATAAGTCAGAAGATGCAAAGTCTGTTCATTTTGAATCCAGCACCTCAGAGTCCTCAGTGCTATCA
AGTAGTAGTCCAGAGAGTACCTTGGTGAAACCAGAGCCGAATGGCATAACCATCCCTGGTATCTCTTCAGATGTGCCAGAGAGTGCCCAC
AAAACTACTGCCTCAGAGGCAAAGTCAGACACTGGGCAGCCTACCAAGGTTGGACGTTTTCAGGTGACAACTACAGCAAACAAAGTGGGT
CGTTTCTCTGTATCAAAAACTGAGGACAAGATCACTGACACAAAGAAAGAAGGACCAGTGGCATCTCCTCCTTTTATGGATTTGGAACAA
GCTGTTCTTCCTGCTGTGATACCAAAGAAAGAGAAGCCTGAACTGTCAGAGCCTTCACATCTAAATGGGCCGTCTTCTGACCCGGAGGCC
GCTTTTTTAAGTAGGGATGTGGATGATGGTTCCGGTAGTCCACACTCGCCCCATCAGCTGAGCTCAAAGAGCCTTCCTAGCCAGAATCTA
AGTCAAAGCCTTAGTAATTCATTTAACTCCTCTTACATGAGTAGCGACAATGAGTCAGATATCGAAGATGAAGACTTAAAGTTAGAGCTG
CGACGACTACGAGATAAACATCTCAAAGAGATTCAGGACCTGCAGAGTCGCCAGAAGCATGAAATTGAATCTTTGTATACCAAACTGGGC
AAGGTGCCCCCTGCTGTTATTATTCCCCCAGCTGCTCCCCTTTCAGGGAGAAGACGACGACCCACTAAAAGCAAAGGCAGCAAATCTAGT
CGAAGCAGTTCCTTGGGGAATAAAAGCCCCCAGCTTTCAGGTAACCTGTCTGGTCAGAGTGCAGCTTCAGTCTTGCACCCCCAGCAGACC
CTCCACCCTCCTGGCAACATCCCAGAGTCCGGGCAGAATCAGCTGTTACAGCCCCTTAAGCCATCTCCCTCCAGTGACAACCTCTATTCA
GCCTTCACCAGTGATGGTGCCATTTCAGTACCAAGCCTTTCTGCTCCAGGTCAAGGAACCAGCAGCACAAACACTGTTGGGGCAACAGTG
AACAGCCAAGCCGCCCAAGCTCAGCCTCCTGCCATGACGTCCAGCAGGAAGGGCACATTCACAGATGACTTGCACAAGTTGGTAGACAAT
TGGGCCCGAGATGCCATGAATCTCTCAGGCAGGAGAGGAAGCAAAGGGCACATGAATTACGAGGGCCCTGGAATGGCAAGGAAGTTCTCT
GCACCTGGGCAACTGTGCATCTCCATGACCTCGAACCTGGGTGGCTCTGCCCCCATCTCTGCAGCATCAGCTACCTCTCTAGGTCACTTC
ACCAAGTCTATGTGCCCCCCACAGCAGTATGGCTTTCCAGCTACCCCATTTGGCGCTCAATGGAGTGGGACGGGTGGCCCAGCACCACAG
CCACTTGGCCAGTTCCAACCTGTGGGAACTGCCTCCTTGCAGAATTTCAACATCAGCAATTTGCAGAAATCCATCAGCAACCCCCCAGGC
TCCAACCTGCGGACCACTTAGACCTAGAGACATTAACTGAATAGATCTGGGGGCAGGAGATGGAATGCTGAGGGGGTGGGTGGGGGTGGG
AAGTAGCCTATATACTAACTACTAGTGCTGCATTTAACTGGTTATTTCTTGCCAGAGGGGAATGTTTTTAATACTGCATTGAGCCCTCAG
AATGGAGAGTCTCCCCCGCTCCAGTTATTGGAATGGGAGAGGAAGGAAAGAACAGCTTTTTTGTCAAGGGGCAGCTTCAGACCATGCTTT
CCTGTTTATCTATACTCAGTAATGAGGATGAGGGCTAGGAAAGTCTTGTTCATAAGGAAGCTGGAGAACTCAATGTAAAATCAAACCCAT
CTGTAATTTCGAGTGGGTGGAGCTCTTGCTTTTGGTACATGCCCTGAATCCCTCACTCCCTCAAGAATCCGAACCACAGGACAAAAACCA
CCTACTGGGCTCTCTCCTACCCTGCCCTCCTCCCTTTTTTTTACCCCTCTCTTTTTTATTTTTTCTTTGCTCTTTAGAACCCAGTGAAAA
ATACCAGGGTACTGGGGTGCAACTCTTTCTTATGATAGGTCATTAGTGCTTTAAGCAAAAGATATTAGCAGCTTTGACTGCAGCATTAGC
AATTAGGAAAAAAAAAAAATTAAGTTCCCTGCGGACATGTAACTTTGCCATCAGTTTTGATGTGGAAACACTGTGATATATAAAATGTTG
TTGGACAACAGTAGTTTTAAGAGTAAAATATGAAACGTTTAAAAAGTTCCAAAAAAAGCTAGCTCTGTCCTTTACTTATTGAGACACTTT
AACTTTTTCCTTTGTATTTCCATTGTATTAGATAAATAAATGTGAATGTAAAATTGTATAAATTACTGTACTTGAATACTTCTGTTTCCC
AGTGTTGCTTGCTGGACATTTTAGTGCCTTGGACTTCTATTGCTTCTGCCATTAGCATCAACTTACCAGACCCCAGATCAATAAAGGGCA
TGTGGAAGGAAATCGTAGGTCCATGTGACCCCAGCAGTCCAGCAGTGGTTATGCCAAAGGGAAATTGAAAAAGTATTTTTTTAAGTCATT
CAACAACTTTGTCTAGAGCAGGTGTAAGATGAGTAGGGTGGGAAGTTAGGTTGGCATCAGTGGTTAAAAACAGAAAGTTCTGTTTCGGGA
ATAGTGAGGAGGGGGTGTTGTAACAAAATTGGACAACTTAAAAGAATGGTGTGTGCTGGGTGAAAGACAAAGACTAAAGAATGAGGAAAC
AAACGTGATGCCTGGCCAGTGACTGTCATATAAACCTTTCTTATTTGAGCTAGGCTTGAACAGACGTGACCTAGAAGAAACTGAACATAA
AGAGAAGGGGGTGGGGGGCTAGTTTTCAAGTTGGGGAACCTGATAGTGAAAAGTCACAGATGGAGAAAATTGCTCTCAGAAAAACTGTTT
GGATTGCTTTCCTCTTGTTGCACATGTACCATGCATTTCTCAGCTTGGGGTACTACATTTTGTGGAAAGTTAATCTATCTATCTTTCCAC
ATCTGAATTAATCATTCTAGGAAAGAATACTTATTCCTACTCATTTCCTTTATGATGTCCAAATGGTTGCAGGATCATAATCTATTGTGC
CACCTTTATTTCTAGAAGTACAACTAATATGTTCACATTTTCAAATAAATAATACTCCCCGTAAGTAATAACTGCAACCAATCAGTGTTA
TTCAGTGCTATGCCTCCTTGTAATGGGTAGTTATTAATTATTTTCAGAGCTTTCCGGAAATACTGTCCTAACTGGCTATGTTTAGGATCT
TTGTTATCTCTGAAGACAAAGAAAGAAGCTAGGACTCTTAATTTTGGGGTGCTTCTTGACTCTTAGTTGGGAAACTGAAAATATTTCCAA
CCTTTTACCCACGTCAATGGCATATTCTGGGAATCACCACCACCACCACCACTACCACAGAAAGAGGCTGGAGGCTCCTGTACCCTGTTC
ATTCCTTAAGGGCCCTGCTTCCCTTAGTAAGTAAGTAAGTTGGTCTACGGCCCTAAATATGCAAATGAGAGCTGAAGGTTTTTAAAAGGT
AGAAAGGAAAAGGGCAAGGGCTTCCACCCCTGCTTTAAAATGATTTATTTATTCTCTGCTTGTATTTCTTGTGGAGAGAGTAAGGATAGA
ACCAACAAGGGGCTGAGTAGCTGAGAAAGGGGCCACCCAAGAGTGAAACATACTTTATACCAGAGGAGCAGTGGAGCCTCATGCAGCACA
TTATCATTTGTTATTTGGGTTTAATAATAATTTTGACATCTTTTCACTCATACACAAAAAAAGTCAGAACTGGTGTTATTTACTGTTGAT
TTCATCCTCCTGTGTATGAAATAACAAGCCTAGAGGAATGAACTAGTGCTACTGAACTGTTTAAATTATTTTTGTGTTAATAGTACACTT
TGAGTATCTTTTTCCACATTAAAAACTTTCTGAATTATAAATGTTTTCCTTACATTATTTAACAATGTACACTGTTAAAAATAAAAATAA

>38120_38120_2_HUWE1-WNK1_HUWE1_chrX_53619357_ENST00000218328_WNK1_chr12_992560_ENST00000535572_length(amino acids)=2547AA_BP=1326
MKIEIMKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPE
REQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKEN
GFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAH
GFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASY
HGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMA
AFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGS
LPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQ
PFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPP
PRSNHAAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTI
LGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHA
LTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQKLVPKDEKAGTTQ
GGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLAPMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCV
GSPVRQRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKYPYHLMLQKFLCSGGHNA
LFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKN
LWNRKPLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQVNNDFILAIERESFVDQVREI
IEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRFIVSPVPESRLRESKVF
PSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSHTGPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPN
DISTSVIQSEVTVPTEEGIAGVATSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSEIVVSSTALYPSVTVS
ATSASAGGSTATPGPKPPAVVSQQAAGSTTVGATLTSVSTTTSFPSTASQLCIQLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSL
SAPSSSSSPGAGVSSYISQPGGLHPLVIPSVIASTPILPQAAGPTSTPLLPQVPSIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTH
CPEVDSDTQPKAPGIDDIKTLEEKLRSLFSEHSSSGAQHASVSLETSLVIESTVTPGIPTTAVAPSKLLTSTTSTCLPPTNLPLGTVALP
VTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPFPGPSLTQSQQPLEDLDAQLRRTLSPEMITVTSA
VGPVSMAAPTAITEAGTQPQKVSQVKEGPVLATSSGAGVFKMGRFQVSVAADGAQKEGKNKSEDAKSVHFESSTSESSVLSSSSPESTLV
KPEPNGITIPGISSDVPESAHKTTASEAKSDTGQPTKVGRFQVTTTANKVGRFSVSKTEDKITDTKKEGPVASPPFMDLEQAVLPAVIPK
KEKPELSEPSHLNGPSSDPEAAFLSRDVDDGSGSPHSPHQLSSKSLPSQNLSQSLSNSFNSSYMSSDNESDIEDEDLKLELRRLRDKHLK
EIQDLQSRQKHEIESLYTKLGKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQSAASVLHPQQTLHPPGNIPE
SGQNQLLQPLKPSPSSDNLYSAFTSDGAISVPSLSAPGQGTSSTNTVGATVNSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLS
GRRGSKGHMNYEGPGMARKFSAPGQLCISMTSNLGGSAPISAASATSLGHFTKSMCPPQQYGFPATPFGAQWSGTGGPAPQPLGQFQPVG

--------------------------------------------------------------
>38120_38120_3_HUWE1-WNK1_HUWE1_chrX_53619357_ENST00000218328_WNK1_chr12_992560_ENST00000537687_length(transcript)=10694nt_BP=4374nt
GAGGCTTTCGACTGAGGGCTAGCGAGGGGAGCACGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGAAGCAGG
GCCGCGGACCCCGCACGCTCCTGCGGGCCCCGCGGAGCCATTGCGGCCGAGGCCTCGGCAGGCGCCAGCGGAGAGCTAGCCGCATCTTCG
GGGGCAGCCCGGCAGCTGCCGGCGGCGCGGCGAGAGAGCGGCTGACAGAGGGGATGCGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTA
GTGATCCAGAGAAACCAGCAGGCCAACTTGGTCAGGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTAT
GATTGGCTGTGATTTTAGATCGTAAAGCTGAAAATTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCT
GCAGACTGCAGAGCCTTAATAGACAAACTCAAAGTTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATT
GGAAAGTGCGAGTTATATCACTGGGTGGACCTGTTGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCA
TGGATGCTCGTATGTGATAGGCCAGAAAGAGAGCAACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTAC
AGCTTTTCCCGGCATCTGTACAGTTCCATAGAGCATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAAT
CTCCTATATGTATTTAGCAAAAGATCAAACTACATCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTG
GCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACT
ACACTACACTTTGAATTCTATGCAGATCCTGGGGCCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATA
GAGCAACTTGACAAGATTTCAGAAAGCCCTTCTGAAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTG
TTATTTACACACATACGACTGGCCCATGGCTTTTCTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATA
TTAGTGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACG
GATAAGCAGCTTATGGAGATTAAAGCAGCTTCTTTACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATT
ATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGAT
CCATACCCTCACCAGTTTGCCACTGCTCTCTTCTCTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGT
GGAATGATGGAAGCCTTATTGAAGGTCATAAAGTTTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTT
GACCTTATCACCAACCTGGATATGGCAGCTTTTCAATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTG
TGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGAT
GGAGTCCAGTGTATTCCACAACGAGCAGCACTTCTGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGAT
GGCATACGACATGTGATGGATGGTTCTCTGCCTACCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTC
CTAGCTACTGAAGTGGTGACTGTGTTTGTATTTCAAGAACCATCACTGCTCTCCTCACTCCAGGACAATGGATTGACAGATGTCATGCTG
CATGCACTGCTTATCAAAGATGTTCCTGCTACCCGTGAAGTCCTTGGCTCCCTCCCAAATGTATTCAGTGCACTCTGTTTGAATGCCCGA
GGTCTTCAGTCTTTTGTTCAGTGTCAGCCTTTTGAACGCCTCTTCAAAGTTCTTCTGTCTCCAGATTACCTCCCAGCCATGCGGAGGAGG
AGAAGTTCTGATCCCCTTGGGGATACTGCATCCAACCTGGGGAGTGCTGTCGATGAGCTCATGAGACATCAGCCCACCCTTAAAACAGAT
GCAACGACTGCCATCATCAAGTTACTTGAAGAAATCTGTAATCTTGGAAGGGACCCCAAATACATCTGTCAGAAGCCATCAATCCAGAAG
GCAGATGGCACTGCCACTGCTCCTCCCCCAAGGTCTAATCATGCCGCAGAAGAAGCCTCTAGTGAGGATGAGGAGGAAGAGGAAGTACAG
GCCATGCAGAGCTTTAATTCTACCCAGCAAAATGAAACTGAGCCTAATCAGCAGGTTGTTGGTACAGAGGAACGTATTCCTATTCCCCTC
ATGGATTACATCCTTAATGTGATGAAATTTGTGGAATCTATTCTGAGCAACAATACAACAGATGACCACTGCCAGGAATTTGTGAATCAG
AAAGGACTGTTGCCTTTGGTTACCATTTTGGGTCTTCCCAATCTGCCCATTGACTTTCCCACATCTGCTGCCTGTCAGGCTGTTGCAGGT
GTCTGCAAATCCATATTGACACTGTCACATGAACCCAAAGTCCTTCAAGAGGGTCTCCTTCAGTTGGACTCCATCCTCTCCTCCCTGGAG
CCCTTACACCGCCCCATTGAATCCCCTGGGGGCTCAGTGTTGTTGCGAGAACTGGCTTGCGCAGGCAATGTTGCTGATGCTACCCTCTCA
GCCCAGGCCACACCTCTGCTGCATGCACTCACTGCTGCCCATGCCTACATCATGATGTTTGTTCATACTTGCAGAGTTGGACAGAGTGAA
ATTCGTTCCATCTCCGTAAACCAGTGGGGCTCTCAATTGGGTCTGAGTGTTTTGAGCAAGCTGAGCCAGTTATACTGTTCCCTGGTGTGG
GAAAGCACTGTCCTCCTCTCTCTGTGTACCCCAAACAGCCTACCATCTGGGTGTGAATTTGGCCAGGCAGATATGCAGAAACTGGTTCCA
AAGGATGAGAAGGCAGGTACGACCCAGGGCGGAAAAAGATCAGATGGGGAACAGGATGGAGCAGCTGGAAGTATGGATGCTTCTACCCAG
GGCTTATTAGAAGGCATTGGGCTAGATGGTGACACATTGGCTCCCATGGAGACAGATGAACCTACTGCTTCAGACTCTAAGGGCAAATCT
AAAATCACACCAGCAATGGCTGCCAGAATTAAGCAAATCAAGCCTTTGTTATCAGCTTCCTCCAGATTAGGCCGAGCACTTGCTGAGCTA
TTTGGACTTCTTGTTAAACTTTGTGTGGGATCTCCTGTCCGCCAGAGAAGGAGCCATCATGCTGCCAGCACCACTACAGCACCGACACCT
GCCGCGCGATCAACAGCCTCAGCTCTCACTAAGCTCTTGACTAAGGGGTTATCTTGGCAGCCCCCACCATATACACCTACTCCCCGATTC
AGGCTGACATTCTTCATCTGTTCAGTTGGTTTCACATCCCCAATGCTGTTTGATGAGAGGAAGTATCCCTACCACCTCATGCTGCAAAAA
TTTCTCTGCTCCGGAGGCCACAATGCTCTTTTTGAAACTTTCAACTGGGCTCTGTCCATGGGAGGTAAAGTTCCTGTTTCTGAGGGATTG
GAACACTCAGACTTGCCTGATGGCACAGGAGAATTCCTAGATGCCTGGCTTATGCTGGTGGAGAAGATGGTGAATCCCACCACGGTGCTT
GAATCTCCACATTCGCTGCCTGCCAAATTGCCTGGAGGTGTCCAGAACTTTCCCCAGTTCAGTGCACTGCGCTTCCTTGTGGTAACTCAG
AAAGCAGCCTTTACTTGCATCAAAAACTTATGGAACCGGAAACCCCTGAAGGTATATGGTGGACGAATGGCTGAATCGATGCTGGCCATT
CTATGCCACATCCTCCGAGGAGAACCTGTGATTCGAGAGAGACTAAGCAAGGAGAAGGAGGGGTCTCGAGGAGAAGAGGATACAGGGCAA
GAGGAAGGTGGCTCCCGCCGGGAACCTCAAGTCAACCAGCAACAACTGCAACAGGTGAACAATGACTTTATTCTAGCAATAGAGAGAGAG
TCGTTTGTGGATCAAGTGCGAGAAATTATTGAAAAAGCTGATGAAATGCTCAGTGAGGATGTCAGTGTGGAACCAGAGGGTGATCAGGGA
TTGGAGAGTCTACAAGGAAAGGATGACTATGGCTTTTCAGGTTCTCAGAAATTGGAAGGAGAGTTCAAACAACCAATTCCTGCGTCTTCC
ATGCCACAGCAAATAGGCATTCCTACCAGTTCTTTAACTCAAGTTGTTCATTCTGCGGGAAGGCGGTTTATAGTGAGTCCTGTGCCAGAA
AGCCGATTACGAGAATCAAAAGTTTTCCCCAGTGAAATAACAGATACAGTTGCTGCCTCTACAGCTCAGAGCCCTGGAATGAACTTGTCT
CACTCTGCATCATCCCTTAGTCTACAACAGGCCTTTTCTGAACTTAGACGTGCCCAAATGACAGAAGGACCCAACACAGCACCTCCAAAC
TTTAGTCATACAGGACCAACATTTCCAGTAGTACCTCCTTTCTTAAGTAGCATTGCTGGAGTCCCAACCACAGCAGCAGCCACAGCACCA
GTCCCTGCAACAAGCAGCCCTCCTAATGACATTTCCACATCAGTAATTCAGTCTGAGGTTACAGTGCCCACTGAAGAGGGGATTGCTGGA
GTTGCCACCAGCACAGGTGTGGTAACTTCAGGTGGTCTCCCCATACCACCTGTGTCTGAATCACCAGTACTTTCCAGCGTAGTTTCAAGT
ATCACAATACCTGCAGTTGTCTCAATATCTACTACATCCCCGTCACTTCAAGTCCCCACATCCACATCTGAGATCGTTGTTTCTAGTACA
GCACTGTATCCTTCAGTAACAGTTTCAGCAACTTCAGCCTCTGCAGGGGGCAGTACTGCTACCCCAGGTCCTAAGCCTCCAGCTGTAGTA
TCTCAGCAGGCAGCAGGCAGCACTACTGTGGGAGCCACATTAACATCAGTTTCTACCACCACTTCATTCCCAAGCACAGCTTCACAGCTG
TGCATTCAGCTTAGCAGCAGTACTTCTACTCCTACTTTAGCTGAAACCGTGGTAGTTAGCGCACACTCACTAGATAAGACATCTCATAGC
AGTACAACTGGATTGGCTTTCTCCCTCTCTGCACCATCTTCCTCTTCCTCTCCTGGAGCAGGAGTGTCTAGTTATATTTCTCAGCCTGGT
GGGCTGCATCCTTTGGTCATTCCATCAGTGATAGCTTCTACTCCTATTCTTCCCCAAGCAGCAGGACCTACTTCTACACCTTTATTACCC
CAAGTACCTAGTATCCCACCCTTGGTACAGCCTGTTGCCAATGTGCCTGCTGTACAGCAGACACTAATTCATAGTCAGCCTCAACCAGCT
TTGCTTCCCAACCAGCCCCATACTCATTGTCCTGAAGTAGATTCTGATACACAACCCAAAGCTCCTGGAATTGATGACATAAAGACTCTA
GAAGAAAAGCTGCGGTCTCTGTTCAGTGAACACAGCTCATCTGGAGCTCAGCATGCCTCTGTCTCACTGGAGACCTCACTAGTCATAGAG
AGCACTGTCACACCAGGCATCCCAACTACTGCTGTTGCACCAAGCAAACTCCTGACTTCTACCACAAGTACTTGCTTACCACCAACCAAT
TTACCACTAGGAACAGTTGCTTTGCCAGTTACACCAGTGGTCACACCTGGGCAAGTTTCTACCCCAGTCAGCACTACTACATCAGGAGTG
AAACCTGGAACTGCTCCCTCCAAGCCACCTCTAACTAAGGCTCCGGTGCTGCCAGTGGGTACTGAACTTCCAGCAGGTACTCTACCCAGC
GAGCAGCTGCCACCTTTTCCAGGACCTTCTCTAACCCAGTCCCAGCAACCTCTAGAGGATCTTGATGCTCAATTGAGAAGAACACTTAGT
CCAGAGATGATCACAGTGACTTCTGCGGTTGGTCCTGTGTCCATGGCGGCTCCAACAGCAATCACAGAAGCAGGAACACAGCCTCAGAAG
GGTGTTTCTCAAGTCAAAGAAGGCCCTGTCCTAGCAACTAGTTCAGGAGCTGGTGTTTTTAAGATGGGACGATTTCAGGTTTCTGTTGCA
GCAGACGGTGCCCAGAAAGAGGGTAAAAATAAGTCAGAAGATGCAAAGTCTGTTCATTTTGAATCCAGCACCTCAGAGTCCTCAGTGCTA
TCAAGTAGTAGTCCAGAGAGTACCTTGGTGAAACCAGAGCCGAATGGCATAACCATCCCTGGTATCTCTTCAGATGTGCCAGAGAGTGCC
CACAAAACTACTGCCTCAGAGGCAAAGTCAGACACTGGGCAGCCTACCAAGGTTGGACGTTTTCAGGTGACAACTACAGCAAACAAAGTG
GGTCGTTTCTCTGTATCAAAAACTGAGGACAAGATCACTGACACAAAGAAAGAAGGACCAGTGGCATCTCCTCCTTTTATGGATTTGGAA
CAAGCTGTTCTTCCTGCTGTGATACCAAAGAAAGAGAAGCCTGAACTGTCAGAGCCTTCACATCTAAATGGGCCGTCTTCTGACCCGGAG
GCCGCTTTTTTAAGTAGGGATGTGGATGATGGTTCCGGTAGTCCACACTCGCCCCATCAGCTGAGCTCAAAGAGCCTTCCTAGCCAGAAT
CTAAGTCAAAGCCTTAGTAATTCATTTAACTCCTCTTACATGAGTAGCGACAATGAGTCAGATATCGAAGATGAAGACTTAAAGTTAGAG
CTGCGACGACTACGAGATAAACATCTCAAAGAGATTCAGGACCTGCAGAGTCGCCAGAAGCATGAAATTGAATCTTTGTATACCAAACTG
GGCAAGGTGCCCCCTGCTGTTATTATTCCCCCAGCTGCTCCCCTTTCAGGGAGAAGACGACGACCCACTAAAAGCAAAGGCAGCAAATCT
AGTCGAAGCAGTTCCTTGGGGAATAAAAGCCCCCAGCTTTCAGGTAACCTGTCTGGTCAGAGTGCAGCTTCAGTCTTGCACCCCCAGCAG
ACCCTCCACCCTCCTGGCAACATCCCAGAGTCCGGGCAGAATCAGCTGTTACAGCCCCTTAAGCCATCTCCCTCCAGTGACAACCTCTAT
TCAGCCTTCACCAGTGATGGTGCCATTTCAGTACCAAGCCTTTCTGCTCCAGGTCAAGGAACCAGCAGCACAAACACTGTTGGGGCAACA
GTGAACAGCCAAGCCGCCCAAGCTCAGCCTCCTGCCATGACGTCCAGCAGGAAGGGCACATTCACAGATGACTTGCACAAGTTGGTAGAC
AATTGGGCCCGAGATGCCATGAATCTCTCAGGCAGGAGAGGAAGCAAAGGGCACATGAATTACGAGGGCCCTGGAATGGCAAGGAAGTTC
TCTGCACCTGGGCAACTGTGCATCTCCATGACCTCGAACCTGGGTGGCTCTGCCCCCATCTCTGCAGCATCAGCTACCTCTCTAGGTCAC
TTCACCAAGTCTATGTGCCCCCCACAGCAGTATGGCTTTCCAGCTACCCCATTTGGCGCTCAATGGAGTGGGACGGGTGGCCCAGCACCA
CAGCCACTTGGCCAGTTCCAACCTGTGGGAACTGCCTCCTTGCAGAATTTCAACATCAGCAATTTGCAGAAATCCATCAGCAACCCCCCA
GGCTCCAACCTGCGGACCACTTAGACCTAGAGACATTAACTGAATAGATCTGGGGGCAGGAGATGGAATGCTGAGGGGGTGGGTGGGGGT
GGGAAGTAGCCTATATACTAACTACTAGTGCTGCATTTAACTGGTTATTTCTTGCCAGAGGGGAATGTTTTTAATACTGCATTGAGCCCT
CAGAATGGAGAGTCTCCCCCGCTCCAGTTATTGGAATGGGAGAGGAAGGAAAGAACAGCTTTTTTGTCAAGGGGCAGCTTCAGACCATGC
TTTCCTGTTTATCTATACTCAGTAATGAGGATGAGGGCTAGGAAAGTCTTGTTCATAAGGAAGCTGGAGAACTCAATGTAAAATCAAACC
CATCTGTAATTTCGAGTGGGTGGAGCTCTTGCTTTTGGTACATGCCCTGAATCCCTCACTCCCTCAAGAATCCGAACCACAGGACAAAAA
CCACCTACTGGGCTCTCTCCTACCCTGCCCTCCTCCCTTTTTTTTACCCCTCTCTTTTTTATTTTTTCTTTGCTCTTTAGAACCCAGTGA
AAAATACCAGGGTACTGGGGTGCAACTCTTTCTTATGATAGGTCATTAGTGCTTTAAGCAAAAGATATTAGCAGCTTTGACTGCAGCATT
AGCAATTAGGAAAAAAAAAAAATTAAGTTCCCTGCGGACATGTAACTTTGCCATCAGTTTTGATGTGGAAACACTGTGATATATAAAATG
TTGTTGGACAACAGTAGTTTTAAGAGTAAAATATGAAACGTTTAAAAAGTTCCAAAAAAAGCTAGCTCTGTCCTTTACTTATTGAGACAC
TTTAACTTTTTCCTTTGTATTTCCATTGTATTAGATAAATAAATGTGAATGTAAAATTGTATAAATTACTGTACTTGAATACTTCTGTTT
CCCAGTGTTGCTTGCTGGACATTTTAGTGCCTTGGACTTCTATTGCTTCTGCCATTAGCATCAACTTACCAGACCCCAGATCAATAAAGG
GCATGTGGAAGGAAATCGTAGGTCCATGTGACCCCAGCAGTCCAGCAGTGGTTATGCCAAAGGGAAATTGAAAAAGTATTTTTTTAAGTC
ATTCAACAACTTTGTCTAGAGCAGGTGTAAGATGAGTAGGGTGGGAAGTTAGGTTGGCATCAGTGGTTAAAAACAGAAAGTTCTGTTTCG
GGAATAGTGAGGAGGGGGTGTTGTAACAAAATTGGACAACTTAAAAGAATGGTGTGTGCTGGGTGAAAGACAAAGACTAAAGAATGAGGA
AACAAACGTGATGCCTGGCCAGTGACTGTCATATAAACCTTTCTTATTTGAGCTAGGCTTGAACAGACGTGACCTAGAAGAAACTGAACA
TAAAGAGAAGGGGGTGGGGGGCTAGTTTTCAAGTTGGGGAACCTGATAGTGAAAAGTCACAGATGGAGAAAATTGCTCTCAGAAAAACTG
TTTGGATTGCTTTCCTCTTGTTGCACATGTACCATGCATTTCTCAGCTTGGGGTACTACATTTTGTGGAAAGTTAATCTATCTATCTTTC
CACATCTGAATTAATCATTCTAGGAAAGAATACTTATTCCTACTCATTTCCTTTATGATGTCCAAATGGTTGCAGGATCATAATCTATTG
TGCCACCTTTATTTCTAGAAGTACAACTAATATGTTCACATTTTCAAATAAATAATACTCCCCGTAAGTAATAACTGCAACCAATCAGTG
TTATTCAGTGCTATGCCTCCTTGTAATGGGTAGTTATTAATTATTTTCAGAGCTTTCCGGAAATACTGTCCTAACTGGCTATGTTTAGGA
TCTTTGTTATCTCTGAAGACAAAGAAAGAAGCTAGGACTCTTAATTTTGGGGTGCTTCTTGACTCTTAGTTGGGAAACTGAAAATATTTC
CAACCTTTTACCCACGTCAATGGCATATTCTGGGAATCACCACCACCACCACCACTACCACAGAAAGAGGCTGGAGGCTCCTGTACCCTG
TTCATTCCTTAAGGGCCCTGCTTCCCTTAGTAAGTAAGTAAGTTGGTCTACGGCCCTAAATATGCAAATGAGAGCTGAAGGTTTTTAAAA
GGTAGAAAGGAAAAGGGCAAGGGCTTCCACCCCTGCTTTAAAATGATTTATTTATTCTCTGCTTGTATTTCTTGTGGAGAGAGTAAGGAT
AGAACCAACAAGGGGCTGAGTAGCTGAGAAAGGGGCCACCCAAGAGTGAAACATACTTTATACCAGAGGAGCAGTGGAGCCTCATGCAGC
ACATTATCATTTGTTATTTGGGTTTAATAATAATTTTGACATCTTTTCACTCATACACAAAAAAAGTCAGAACTGGTGTTATTTACTGTT
GATTTCATCCTCCTGTGTATGAAATAACAAGCCTAGAGGAATGAACTAGTGCTACTGAACTGTTTAAATTATTTTTGTGTTAATAGTACA
CTTTGAGTATCTTTTTCCACATTAAAAACTTTCTGAATTATAAATGTTTTCCTTACATTATTTAACAATGTACACTGTTAAAAATAAAAA
TAAAAATTCAAACTTTGGGGGTTTCTCAGCAGCCGTTAATTGTACATTTTGCACTAACTCTGGGTGTTGCGCTTCTTGTAAGATTGCGCT

>38120_38120_3_HUWE1-WNK1_HUWE1_chrX_53619357_ENST00000218328_WNK1_chr12_992560_ENST00000537687_length(amino acids)=2548AA_BP=1326
MKIEIMKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPE
REQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKEN
GFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAH
GFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASY
HGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMA
AFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGS
LPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQ
PFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPP
PRSNHAAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTI
LGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHA
LTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQKLVPKDEKAGTTQ
GGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLAPMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCV
GSPVRQRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKYPYHLMLQKFLCSGGHNA
LFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKN
LWNRKPLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQVNNDFILAIERESFVDQVREI
IEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRFIVSPVPESRLRESKVF
PSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSHTGPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPN
DISTSVIQSEVTVPTEEGIAGVATSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSEIVVSSTALYPSVTVS
ATSASAGGSTATPGPKPPAVVSQQAAGSTTVGATLTSVSTTTSFPSTASQLCIQLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSL
SAPSSSSSPGAGVSSYISQPGGLHPLVIPSVIASTPILPQAAGPTSTPLLPQVPSIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTH
CPEVDSDTQPKAPGIDDIKTLEEKLRSLFSEHSSSGAQHASVSLETSLVIESTVTPGIPTTAVAPSKLLTSTTSTCLPPTNLPLGTVALP
VTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPFPGPSLTQSQQPLEDLDAQLRRTLSPEMITVTSA
VGPVSMAAPTAITEAGTQPQKGVSQVKEGPVLATSSGAGVFKMGRFQVSVAADGAQKEGKNKSEDAKSVHFESSTSESSVLSSSSPESTL
VKPEPNGITIPGISSDVPESAHKTTASEAKSDTGQPTKVGRFQVTTTANKVGRFSVSKTEDKITDTKKEGPVASPPFMDLEQAVLPAVIP
KKEKPELSEPSHLNGPSSDPEAAFLSRDVDDGSGSPHSPHQLSSKSLPSQNLSQSLSNSFNSSYMSSDNESDIEDEDLKLELRRLRDKHL
KEIQDLQSRQKHEIESLYTKLGKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQSAASVLHPQQTLHPPGNIP
ESGQNQLLQPLKPSPSSDNLYSAFTSDGAISVPSLSAPGQGTSSTNTVGATVNSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNL
SGRRGSKGHMNYEGPGMARKFSAPGQLCISMTSNLGGSAPISAASATSLGHFTKSMCPPQQYGFPATPFGAQWSGTGGPAPQPLGQFQPV

--------------------------------------------------------------
>38120_38120_4_HUWE1-WNK1_HUWE1_chrX_53619357_ENST00000262854_WNK1_chr12_992560_ENST00000315939_length(transcript)=10694nt_BP=4374nt
GAGGCTTTCGACTGAGGGCTAGCGAGGGGAGCACGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGAAGCAGG
GCCGCGGACCCCGCACGCTCCTGCGGGCCCCGCGGAGCCATTGCGGCCGAGGCCTCGGCAGGCGCCAGCGGAGAGCTAGCCGCATCTTCG
GGGGCAGCCCGGCAGCTGCCGGCGGCGCGGCGAGAGAGCGGCTGACAGAGGGGATGCGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTA
GTGATCCAGAGAAACCAGCAGGCCAACTTGGTCAGGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTAT
GATTGGCTGTGATTTTAGATCGTAAAGCTGAAAATTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCT
GCAGACTGCAGAGCCTTAATAGACAAACTCAAAGTTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATT
GGAAAGTGCGAGTTATATCACTGGGTGGACCTGTTGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCA
TGGATGCTCGTATGTGATAGGCCAGAAAGAGAGCAACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTAC
AGCTTTTCCCGGCATCTGTACAGTTCCATAGAGCATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAAT
CTCCTATATGTATTTAGCAAAAGATCAAACTACATCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTG
GCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACT
ACACTACACTTTGAATTCTATGCAGATCCTGGGGCCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATA
GAGCAACTTGACAAGATTTCAGAAAGCCCTTCTGAAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTG
TTATTTACACACATACGACTGGCCCATGGCTTTTCTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATA
TTAGTGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACG
GATAAGCAGCTTATGGAGATTAAAGCAGCTTCTTTACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATT
ATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGAT
CCATACCCTCACCAGTTTGCCACTGCTCTCTTCTCTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGT
GGAATGATGGAAGCCTTATTGAAGGTCATAAAGTTTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTT
GACCTTATCACCAACCTGGATATGGCAGCTTTTCAATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTG
TGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGAT
GGAGTCCAGTGTATTCCACAACGAGCAGCACTTCTGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGAT
GGCATACGACATGTGATGGATGGTTCTCTGCCTACCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTC
CTAGCTACTGAAGTGGTGACTGTGTTTGTATTTCAAGAACCATCACTGCTCTCCTCACTCCAGGACAATGGATTGACAGATGTCATGCTG
CATGCACTGCTTATCAAAGATGTTCCTGCTACCCGTGAAGTCCTTGGCTCCCTCCCAAATGTATTCAGTGCACTCTGTTTGAATGCCCGA
GGTCTTCAGTCTTTTGTTCAGTGTCAGCCTTTTGAACGCCTCTTCAAAGTTCTTCTGTCTCCAGATTACCTCCCAGCCATGCGGAGGAGG
AGAAGTTCTGATCCCCTTGGGGATACTGCATCCAACCTGGGGAGTGCTGTCGATGAGCTCATGAGACATCAGCCCACCCTTAAAACAGAT
GCAACGACTGCCATCATCAAGTTACTTGAAGAAATCTGTAATCTTGGAAGGGACCCCAAATACATCTGTCAGAAGCCATCAATCCAGAAG
GCAGATGGCACTGCCACTGCTCCTCCCCCAAGGTCTAATCATGCCGCAGAAGAAGCCTCTAGTGAGGATGAGGAGGAAGAGGAAGTACAG
GCCATGCAGAGCTTTAATTCTACCCAGCAAAATGAAACTGAGCCTAATCAGCAGGTTGTTGGTACAGAGGAACGTATTCCTATTCCCCTC
ATGGATTACATCCTTAATGTGATGAAATTTGTGGAATCTATTCTGAGCAACAATACAACAGATGACCACTGCCAGGAATTTGTGAATCAG
AAAGGACTGTTGCCTTTGGTTACCATTTTGGGTCTTCCCAATCTGCCCATTGACTTTCCCACATCTGCTGCCTGTCAGGCTGTTGCAGGT
GTCTGCAAATCCATATTGACACTGTCACATGAACCCAAAGTCCTTCAAGAGGGTCTCCTTCAGTTGGACTCCATCCTCTCCTCCCTGGAG
CCCTTACACCGCCCCATTGAATCCCCTGGGGGCTCAGTGTTGTTGCGAGAACTGGCTTGCGCAGGCAATGTTGCTGATGCTACCCTCTCA
GCCCAGGCCACACCTCTGCTGCATGCACTCACTGCTGCCCATGCCTACATCATGATGTTTGTTCATACTTGCAGAGTTGGACAGAGTGAA
ATTCGTTCCATCTCCGTAAACCAGTGGGGCTCTCAATTGGGTCTGAGTGTTTTGAGCAAGCTGAGCCAGTTATACTGTTCCCTGGTGTGG
GAAAGCACTGTCCTCCTCTCTCTGTGTACCCCAAACAGCCTACCATCTGGGTGTGAATTTGGCCAGGCAGATATGCAGAAACTGGTTCCA
AAGGATGAGAAGGCAGGTACGACCCAGGGCGGAAAAAGATCAGATGGGGAACAGGATGGAGCAGCTGGAAGTATGGATGCTTCTACCCAG
GGCTTATTAGAAGGCATTGGGCTAGATGGTGACACATTGGCTCCCATGGAGACAGATGAACCTACTGCTTCAGACTCTAAGGGCAAATCT
AAAATCACACCAGCAATGGCTGCCAGAATTAAGCAAATCAAGCCTTTGTTATCAGCTTCCTCCAGATTAGGCCGAGCACTTGCTGAGCTA
TTTGGACTTCTTGTTAAACTTTGTGTGGGATCTCCTGTCCGCCAGAGAAGGAGCCATCATGCTGCCAGCACCACTACAGCACCGACACCT
GCCGCGCGATCAACAGCCTCAGCTCTCACTAAGCTCTTGACTAAGGGGTTATCTTGGCAGCCCCCACCATATACACCTACTCCCCGATTC
AGGCTGACATTCTTCATCTGTTCAGTTGGTTTCACATCCCCAATGCTGTTTGATGAGAGGAAGTATCCCTACCACCTCATGCTGCAAAAA
TTTCTCTGCTCCGGAGGCCACAATGCTCTTTTTGAAACTTTCAACTGGGCTCTGTCCATGGGAGGTAAAGTTCCTGTTTCTGAGGGATTG
GAACACTCAGACTTGCCTGATGGCACAGGAGAATTCCTAGATGCCTGGCTTATGCTGGTGGAGAAGATGGTGAATCCCACCACGGTGCTT
GAATCTCCACATTCGCTGCCTGCCAAATTGCCTGGAGGTGTCCAGAACTTTCCCCAGTTCAGTGCACTGCGCTTCCTTGTGGTAACTCAG
AAAGCAGCCTTTACTTGCATCAAAAACTTATGGAACCGGAAACCCCTGAAGGTATATGGTGGACGAATGGCTGAATCGATGCTGGCCATT
CTATGCCACATCCTCCGAGGAGAACCTGTGATTCGAGAGAGACTAAGCAAGGAGAAGGAGGGGTCTCGAGGAGAAGAGGATACAGGGCAA
GAGGAAGGTGGCTCCCGCCGGGAACCTCAAGTCAACCAGCAACAACTGCAACAGGTGAACAATGACTTTATTCTAGCAATAGAGAGAGAG
TCGTTTGTGGATCAAGTGCGAGAAATTATTGAAAAAGCTGATGAAATGCTCAGTGAGGATGTCAGTGTGGAACCAGAGGGTGATCAGGGA
TTGGAGAGTCTACAAGGAAAGGATGACTATGGCTTTTCAGGTTCTCAGAAATTGGAAGGAGAGTTCAAACAACCAATTCCTGCGTCTTCC
ATGCCACAGCAAATAGGCATTCCTACCAGTTCTTTAACTCAAGTTGTTCATTCTGCGGGAAGGCGGTTTATAGTGAGTCCTGTGCCAGAA
AGCCGATTACGAGAATCAAAAGTTTTCCCCAGTGAAATAACAGATACAGTTGCTGCCTCTACAGCTCAGAGCCCTGGAATGAACTTGTCT
CACTCTGCATCATCCCTTAGTCTACAACAGGCCTTTTCTGAACTTAGACGTGCCCAAATGACAGAAGGACCCAACACAGCACCTCCAAAC
TTTAGTCATACAGGACCAACATTTCCAGTAGTACCTCCTTTCTTAAGTAGCATTGCTGGAGTCCCAACCACAGCAGCAGCCACAGCACCA
GTCCCTGCAACAAGCAGCCCTCCTAATGACATTTCCACATCAGTAATTCAGTCTGAGGTTACAGTGCCCACTGAAGAGGGGATTGCTGGA
GTTGCCACCAGCACAGGTGTGGTAACTTCAGGTGGTCTCCCCATACCACCTGTGTCTGAATCACCAGTACTTTCCAGCGTAGTTTCAAGT
ATCACAATACCTGCAGTTGTCTCAATATCTACTACATCCCCGTCACTTCAAGTCCCCACATCCACATCTGAGATCGTTGTTTCTAGTACA
GCACTGTATCCTTCAGTAACAGTTTCAGCAACTTCAGCCTCTGCAGGGGGCAGTACTGCTACCCCAGGTCCTAAGCCTCCAGCTGTAGTA
TCTCAGCAGGCAGCAGGCAGCACTACTGTGGGAGCCACATTAACATCAGTTTCTACCACCACTTCATTCCCAAGCACAGCTTCACAGCTG
TGCATTCAGCTTAGCAGCAGTACTTCTACTCCTACTTTAGCTGAAACCGTGGTAGTTAGCGCACACTCACTAGATAAGACATCTCATAGC
AGTACAACTGGATTGGCTTTCTCCCTCTCTGCACCATCTTCCTCTTCCTCTCCTGGAGCAGGAGTGTCTAGTTATATTTCTCAGCCTGGT
GGGCTGCATCCTTTGGTCATTCCATCAGTGATAGCTTCTACTCCTATTCTTCCCCAAGCAGCAGGACCTACTTCTACACCTTTATTACCC
CAAGTACCTAGTATCCCACCCTTGGTACAGCCTGTTGCCAATGTGCCTGCTGTACAGCAGACACTAATTCATAGTCAGCCTCAACCAGCT
TTGCTTCCCAACCAGCCCCATACTCATTGTCCTGAAGTAGATTCTGATACACAACCCAAAGCTCCTGGAATTGATGACATAAAGACTCTA
GAAGAAAAGCTGCGGTCTCTGTTCAGTGAACACAGCTCATCTGGAGCTCAGCATGCCTCTGTCTCACTGGAGACCTCACTAGTCATAGAG
AGCACTGTCACACCAGGCATCCCAACTACTGCTGTTGCACCAAGCAAACTCCTGACTTCTACCACAAGTACTTGCTTACCACCAACCAAT
TTACCACTAGGAACAGTTGCTTTGCCAGTTACACCAGTGGTCACACCTGGGCAAGTTTCTACCCCAGTCAGCACTACTACATCAGGAGTG
AAACCTGGAACTGCTCCCTCCAAGCCACCTCTAACTAAGGCTCCGGTGCTGCCAGTGGGTACTGAACTTCCAGCAGGTACTCTACCCAGC
GAGCAGCTGCCACCTTTTCCAGGACCTTCTCTAACCCAGTCCCAGCAACCTCTAGAGGATCTTGATGCTCAATTGAGAAGAACACTTAGT
CCAGAGATGATCACAGTGACTTCTGCGGTTGGTCCTGTGTCCATGGCGGCTCCAACAGCAATCACAGAAGCAGGAACACAGCCTCAGAAG
GGTGTTTCTCAAGTCAAAGAAGGCCCTGTCCTAGCAACTAGTTCAGGAGCTGGTGTTTTTAAGATGGGACGATTTCAGGTTTCTGTTGCA
GCAGACGGTGCCCAGAAAGAGGGTAAAAATAAGTCAGAAGATGCAAAGTCTGTTCATTTTGAATCCAGCACCTCAGAGTCCTCAGTGCTA
TCAAGTAGTAGTCCAGAGAGTACCTTGGTGAAACCAGAGCCGAATGGCATAACCATCCCTGGTATCTCTTCAGATGTGCCAGAGAGTGCC
CACAAAACTACTGCCTCAGAGGCAAAGTCAGACACTGGGCAGCCTACCAAGGTTGGACGTTTTCAGGTGACAACTACAGCAAACAAAGTG
GGTCGTTTCTCTGTATCAAAAACTGAGGACAAGATCACTGACACAAAGAAAGAAGGACCAGTGGCATCTCCTCCTTTTATGGATTTGGAA
CAAGCTGTTCTTCCTGCTGTGATACCAAAGAAAGAGAAGCCTGAACTGTCAGAGCCTTCACATCTAAATGGGCCGTCTTCTGACCCGGAG
GCCGCTTTTTTAAGTAGGGATGTGGATGATGGTTCCGGTAGTCCACACTCGCCCCATCAGCTGAGCTCAAAGAGCCTTCCTAGCCAGAAT
CTAAGTCAAAGCCTTAGTAATTCATTTAACTCCTCTTACATGAGTAGCGACAATGAGTCAGATATCGAAGATGAAGACTTAAAGTTAGAG
CTGCGACGACTACGAGATAAACATCTCAAAGAGATTCAGGACCTGCAGAGTCGCCAGAAGCATGAAATTGAATCTTTGTATACCAAACTG
GGCAAGGTGCCCCCTGCTGTTATTATTCCCCCAGCTGCTCCCCTTTCAGGGAGAAGACGACGACCCACTAAAAGCAAAGGCAGCAAATCT
AGTCGAAGCAGTTCCTTGGGGAATAAAAGCCCCCAGCTTTCAGGTAACCTGTCTGGTCAGAGTGCAGCTTCAGTCTTGCACCCCCAGCAG
ACCCTCCACCCTCCTGGCAACATCCCAGAGTCCGGGCAGAATCAGCTGTTACAGCCCCTTAAGCCATCTCCCTCCAGTGACAACCTCTAT
TCAGCCTTCACCAGTGATGGTGCCATTTCAGTACCAAGCCTTTCTGCTCCAGGTCAAGGAACCAGCAGCACAAACACTGTTGGGGCAACA
GTGAACAGCCAAGCCGCCCAAGCTCAGCCTCCTGCCATGACGTCCAGCAGGAAGGGCACATTCACAGATGACTTGCACAAGTTGGTAGAC
AATTGGGCCCGAGATGCCATGAATCTCTCAGGCAGGAGAGGAAGCAAAGGGCACATGAATTACGAGGGCCCTGGAATGGCAAGGAAGTTC
TCTGCACCTGGGCAACTGTGCATCTCCATGACCTCGAACCTGGGTGGCTCTGCCCCCATCTCTGCAGCATCAGCTACCTCTCTAGGTCAC
TTCACCAAGTCTATGTGCCCCCCACAGCAGTATGGCTTTCCAGCTACCCCATTTGGCGCTCAATGGAGTGGGACGGGTGGCCCAGCACCA
CAGCCACTTGGCCAGTTCCAACCTGTGGGAACTGCCTCCTTGCAGAATTTCAACATCAGCAATTTGCAGAAATCCATCAGCAACCCCCCA
GGCTCCAACCTGCGGACCACTTAGACCTAGAGACATTAACTGAATAGATCTGGGGGCAGGAGATGGAATGCTGAGGGGGTGGGTGGGGGT
GGGAAGTAGCCTATATACTAACTACTAGTGCTGCATTTAACTGGTTATTTCTTGCCAGAGGGGAATGTTTTTAATACTGCATTGAGCCCT
CAGAATGGAGAGTCTCCCCCGCTCCAGTTATTGGAATGGGAGAGGAAGGAAAGAACAGCTTTTTTGTCAAGGGGCAGCTTCAGACCATGC
TTTCCTGTTTATCTATACTCAGTAATGAGGATGAGGGCTAGGAAAGTCTTGTTCATAAGGAAGCTGGAGAACTCAATGTAAAATCAAACC
CATCTGTAATTTCGAGTGGGTGGAGCTCTTGCTTTTGGTACATGCCCTGAATCCCTCACTCCCTCAAGAATCCGAACCACAGGACAAAAA
CCACCTACTGGGCTCTCTCCTACCCTGCCCTCCTCCCTTTTTTTTACCCCTCTCTTTTTTATTTTTTCTTTGCTCTTTAGAACCCAGTGA
AAAATACCAGGGTACTGGGGTGCAACTCTTTCTTATGATAGGTCATTAGTGCTTTAAGCAAAAGATATTAGCAGCTTTGACTGCAGCATT
AGCAATTAGGAAAAAAAAAAAATTAAGTTCCCTGCGGACATGTAACTTTGCCATCAGTTTTGATGTGGAAACACTGTGATATATAAAATG
TTGTTGGACAACAGTAGTTTTAAGAGTAAAATATGAAACGTTTAAAAAGTTCCAAAAAAAGCTAGCTCTGTCCTTTACTTATTGAGACAC
TTTAACTTTTTCCTTTGTATTTCCATTGTATTAGATAAATAAATGTGAATGTAAAATTGTATAAATTACTGTACTTGAATACTTCTGTTT
CCCAGTGTTGCTTGCTGGACATTTTAGTGCCTTGGACTTCTATTGCTTCTGCCATTAGCATCAACTTACCAGACCCCAGATCAATAAAGG
GCATGTGGAAGGAAATCGTAGGTCCATGTGACCCCAGCAGTCCAGCAGTGGTTATGCCAAAGGGAAATTGAAAAAGTATTTTTTTAAGTC
ATTCAACAACTTTGTCTAGAGCAGGTGTAAGATGAGTAGGGTGGGAAGTTAGGTTGGCATCAGTGGTTAAAAACAGAAAGTTCTGTTTCG
GGAATAGTGAGGAGGGGGTGTTGTAACAAAATTGGACAACTTAAAAGAATGGTGTGTGCTGGGTGAAAGACAAAGACTAAAGAATGAGGA
AACAAACGTGATGCCTGGCCAGTGACTGTCATATAAACCTTTCTTATTTGAGCTAGGCTTGAACAGACGTGACCTAGAAGAAACTGAACA
TAAAGAGAAGGGGGTGGGGGGCTAGTTTTCAAGTTGGGGAACCTGATAGTGAAAAGTCACAGATGGAGAAAATTGCTCTCAGAAAAACTG
TTTGGATTGCTTTCCTCTTGTTGCACATGTACCATGCATTTCTCAGCTTGGGGTACTACATTTTGTGGAAAGTTAATCTATCTATCTTTC
CACATCTGAATTAATCATTCTAGGAAAGAATACTTATTCCTACTCATTTCCTTTATGATGTCCAAATGGTTGCAGGATCATAATCTATTG
TGCCACCTTTATTTCTAGAAGTACAACTAATATGTTCACATTTTCAAATAAATAATACTCCCCGTAAGTAATAACTGCAACCAATCAGTG
TTATTCAGTGCTATGCCTCCTTGTAATGGGTAGTTATTAATTATTTTCAGAGCTTTCCGGAAATACTGTCCTAACTGGCTATGTTTAGGA
TCTTTGTTATCTCTGAAGACAAAGAAAGAAGCTAGGACTCTTAATTTTGGGGTGCTTCTTGACTCTTAGTTGGGAAACTGAAAATATTTC
CAACCTTTTACCCACGTCAATGGCATATTCTGGGAATCACCACCACCACCACCACTACCACAGAAAGAGGCTGGAGGCTCCTGTACCCTG
TTCATTCCTTAAGGGCCCTGCTTCCCTTAGTAAGTAAGTAAGTTGGTCTACGGCCCTAAATATGCAAATGAGAGCTGAAGGTTTTTAAAA
GGTAGAAAGGAAAAGGGCAAGGGCTTCCACCCCTGCTTTAAAATGATTTATTTATTCTCTGCTTGTATTTCTTGTGGAGAGAGTAAGGAT
AGAACCAACAAGGGGCTGAGTAGCTGAGAAAGGGGCCACCCAAGAGTGAAACATACTTTATACCAGAGGAGCAGTGGAGCCTCATGCAGC
ACATTATCATTTGTTATTTGGGTTTAATAATAATTTTGACATCTTTTCACTCATACACAAAAAAAGTCAGAACTGGTGTTATTTACTGTT
GATTTCATCCTCCTGTGTATGAAATAACAAGCCTAGAGGAATGAACTAGTGCTACTGAACTGTTTAAATTATTTTTGTGTTAATAGTACA
CTTTGAGTATCTTTTTCCACATTAAAAACTTTCTGAATTATAAATGTTTTCCTTACATTATTTAACAATGTACACTGTTAAAAATAAAAA
TAAAAATTCAAACTTTGGGGGTTTCTCAGCAGCCGTTAATTGTACATTTTGCACTAACTCTGGGTGTTGCGCTTCTTGTAAGATTGCGCT

>38120_38120_4_HUWE1-WNK1_HUWE1_chrX_53619357_ENST00000262854_WNK1_chr12_992560_ENST00000315939_length(amino acids)=2548AA_BP=1326
MKIEIMKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPE
REQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKEN
GFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAH
GFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASY
HGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMA
AFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGS
LPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQ
PFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPP
PRSNHAAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTI
LGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHA
LTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQKLVPKDEKAGTTQ
GGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLAPMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCV
GSPVRQRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKYPYHLMLQKFLCSGGHNA
LFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKN
LWNRKPLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQVNNDFILAIERESFVDQVREI
IEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRFIVSPVPESRLRESKVF
PSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSHTGPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPN
DISTSVIQSEVTVPTEEGIAGVATSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSEIVVSSTALYPSVTVS
ATSASAGGSTATPGPKPPAVVSQQAAGSTTVGATLTSVSTTTSFPSTASQLCIQLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSL
SAPSSSSSPGAGVSSYISQPGGLHPLVIPSVIASTPILPQAAGPTSTPLLPQVPSIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTH
CPEVDSDTQPKAPGIDDIKTLEEKLRSLFSEHSSSGAQHASVSLETSLVIESTVTPGIPTTAVAPSKLLTSTTSTCLPPTNLPLGTVALP
VTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPFPGPSLTQSQQPLEDLDAQLRRTLSPEMITVTSA
VGPVSMAAPTAITEAGTQPQKGVSQVKEGPVLATSSGAGVFKMGRFQVSVAADGAQKEGKNKSEDAKSVHFESSTSESSVLSSSSPESTL
VKPEPNGITIPGISSDVPESAHKTTASEAKSDTGQPTKVGRFQVTTTANKVGRFSVSKTEDKITDTKKEGPVASPPFMDLEQAVLPAVIP
KKEKPELSEPSHLNGPSSDPEAAFLSRDVDDGSGSPHSPHQLSSKSLPSQNLSQSLSNSFNSSYMSSDNESDIEDEDLKLELRRLRDKHL
KEIQDLQSRQKHEIESLYTKLGKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQSAASVLHPQQTLHPPGNIP
ESGQNQLLQPLKPSPSSDNLYSAFTSDGAISVPSLSAPGQGTSSTNTVGATVNSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNL
SGRRGSKGHMNYEGPGMARKFSAPGQLCISMTSNLGGSAPISAASATSLGHFTKSMCPPQQYGFPATPFGAQWSGTGGPAPQPLGQFQPV

--------------------------------------------------------------
>38120_38120_5_HUWE1-WNK1_HUWE1_chrX_53619357_ENST00000262854_WNK1_chr12_992560_ENST00000535572_length(transcript)=10539nt_BP=4374nt
GAGGCTTTCGACTGAGGGCTAGCGAGGGGAGCACGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGAAGCAGG
GCCGCGGACCCCGCACGCTCCTGCGGGCCCCGCGGAGCCATTGCGGCCGAGGCCTCGGCAGGCGCCAGCGGAGAGCTAGCCGCATCTTCG
GGGGCAGCCCGGCAGCTGCCGGCGGCGCGGCGAGAGAGCGGCTGACAGAGGGGATGCGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTA
GTGATCCAGAGAAACCAGCAGGCCAACTTGGTCAGGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTAT
GATTGGCTGTGATTTTAGATCGTAAAGCTGAAAATTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCT
GCAGACTGCAGAGCCTTAATAGACAAACTCAAAGTTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATT
GGAAAGTGCGAGTTATATCACTGGGTGGACCTGTTGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCA
TGGATGCTCGTATGTGATAGGCCAGAAAGAGAGCAACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTAC
AGCTTTTCCCGGCATCTGTACAGTTCCATAGAGCATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAAT
CTCCTATATGTATTTAGCAAAAGATCAAACTACATCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTG
GCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACT
ACACTACACTTTGAATTCTATGCAGATCCTGGGGCCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATA
GAGCAACTTGACAAGATTTCAGAAAGCCCTTCTGAAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTG
TTATTTACACACATACGACTGGCCCATGGCTTTTCTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATA
TTAGTGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACG
GATAAGCAGCTTATGGAGATTAAAGCAGCTTCTTTACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATT
ATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGAT
CCATACCCTCACCAGTTTGCCACTGCTCTCTTCTCTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGT
GGAATGATGGAAGCCTTATTGAAGGTCATAAAGTTTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTT
GACCTTATCACCAACCTGGATATGGCAGCTTTTCAATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTG
TGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGAT
GGAGTCCAGTGTATTCCACAACGAGCAGCACTTCTGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGAT
GGCATACGACATGTGATGGATGGTTCTCTGCCTACCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTC
CTAGCTACTGAAGTGGTGACTGTGTTTGTATTTCAAGAACCATCACTGCTCTCCTCACTCCAGGACAATGGATTGACAGATGTCATGCTG
CATGCACTGCTTATCAAAGATGTTCCTGCTACCCGTGAAGTCCTTGGCTCCCTCCCAAATGTATTCAGTGCACTCTGTTTGAATGCCCGA
GGTCTTCAGTCTTTTGTTCAGTGTCAGCCTTTTGAACGCCTCTTCAAAGTTCTTCTGTCTCCAGATTACCTCCCAGCCATGCGGAGGAGG
AGAAGTTCTGATCCCCTTGGGGATACTGCATCCAACCTGGGGAGTGCTGTCGATGAGCTCATGAGACATCAGCCCACCCTTAAAACAGAT
GCAACGACTGCCATCATCAAGTTACTTGAAGAAATCTGTAATCTTGGAAGGGACCCCAAATACATCTGTCAGAAGCCATCAATCCAGAAG
GCAGATGGCACTGCCACTGCTCCTCCCCCAAGGTCTAATCATGCCGCAGAAGAAGCCTCTAGTGAGGATGAGGAGGAAGAGGAAGTACAG
GCCATGCAGAGCTTTAATTCTACCCAGCAAAATGAAACTGAGCCTAATCAGCAGGTTGTTGGTACAGAGGAACGTATTCCTATTCCCCTC
ATGGATTACATCCTTAATGTGATGAAATTTGTGGAATCTATTCTGAGCAACAATACAACAGATGACCACTGCCAGGAATTTGTGAATCAG
AAAGGACTGTTGCCTTTGGTTACCATTTTGGGTCTTCCCAATCTGCCCATTGACTTTCCCACATCTGCTGCCTGTCAGGCTGTTGCAGGT
GTCTGCAAATCCATATTGACACTGTCACATGAACCCAAAGTCCTTCAAGAGGGTCTCCTTCAGTTGGACTCCATCCTCTCCTCCCTGGAG
CCCTTACACCGCCCCATTGAATCCCCTGGGGGCTCAGTGTTGTTGCGAGAACTGGCTTGCGCAGGCAATGTTGCTGATGCTACCCTCTCA
GCCCAGGCCACACCTCTGCTGCATGCACTCACTGCTGCCCATGCCTACATCATGATGTTTGTTCATACTTGCAGAGTTGGACAGAGTGAA
ATTCGTTCCATCTCCGTAAACCAGTGGGGCTCTCAATTGGGTCTGAGTGTTTTGAGCAAGCTGAGCCAGTTATACTGTTCCCTGGTGTGG
GAAAGCACTGTCCTCCTCTCTCTGTGTACCCCAAACAGCCTACCATCTGGGTGTGAATTTGGCCAGGCAGATATGCAGAAACTGGTTCCA
AAGGATGAGAAGGCAGGTACGACCCAGGGCGGAAAAAGATCAGATGGGGAACAGGATGGAGCAGCTGGAAGTATGGATGCTTCTACCCAG
GGCTTATTAGAAGGCATTGGGCTAGATGGTGACACATTGGCTCCCATGGAGACAGATGAACCTACTGCTTCAGACTCTAAGGGCAAATCT
AAAATCACACCAGCAATGGCTGCCAGAATTAAGCAAATCAAGCCTTTGTTATCAGCTTCCTCCAGATTAGGCCGAGCACTTGCTGAGCTA
TTTGGACTTCTTGTTAAACTTTGTGTGGGATCTCCTGTCCGCCAGAGAAGGAGCCATCATGCTGCCAGCACCACTACAGCACCGACACCT
GCCGCGCGATCAACAGCCTCAGCTCTCACTAAGCTCTTGACTAAGGGGTTATCTTGGCAGCCCCCACCATATACACCTACTCCCCGATTC
AGGCTGACATTCTTCATCTGTTCAGTTGGTTTCACATCCCCAATGCTGTTTGATGAGAGGAAGTATCCCTACCACCTCATGCTGCAAAAA
TTTCTCTGCTCCGGAGGCCACAATGCTCTTTTTGAAACTTTCAACTGGGCTCTGTCCATGGGAGGTAAAGTTCCTGTTTCTGAGGGATTG
GAACACTCAGACTTGCCTGATGGCACAGGAGAATTCCTAGATGCCTGGCTTATGCTGGTGGAGAAGATGGTGAATCCCACCACGGTGCTT
GAATCTCCACATTCGCTGCCTGCCAAATTGCCTGGAGGTGTCCAGAACTTTCCCCAGTTCAGTGCACTGCGCTTCCTTGTGGTAACTCAG
AAAGCAGCCTTTACTTGCATCAAAAACTTATGGAACCGGAAACCCCTGAAGGTATATGGTGGACGAATGGCTGAATCGATGCTGGCCATT
CTATGCCACATCCTCCGAGGAGAACCTGTGATTCGAGAGAGACTAAGCAAGGAGAAGGAGGGGTCTCGAGGAGAAGAGGATACAGGGCAA
GAGGAAGGTGGCTCCCGCCGGGAACCTCAAGTCAACCAGCAACAACTGCAACAGGTGAACAATGACTTTATTCTAGCAATAGAGAGAGAG
TCGTTTGTGGATCAAGTGCGAGAAATTATTGAAAAAGCTGATGAAATGCTCAGTGAGGATGTCAGTGTGGAACCAGAGGGTGATCAGGGA
TTGGAGAGTCTACAAGGAAAGGATGACTATGGCTTTTCAGGTTCTCAGAAATTGGAAGGAGAGTTCAAACAACCAATTCCTGCGTCTTCC
ATGCCACAGCAAATAGGCATTCCTACCAGTTCTTTAACTCAAGTTGTTCATTCTGCGGGAAGGCGGTTTATAGTGAGTCCTGTGCCAGAA
AGCCGATTACGAGAATCAAAAGTTTTCCCCAGTGAAATAACAGATACAGTTGCTGCCTCTACAGCTCAGAGCCCTGGAATGAACTTGTCT
CACTCTGCATCATCCCTTAGTCTACAACAGGCCTTTTCTGAACTTAGACGTGCCCAAATGACAGAAGGACCCAACACAGCACCTCCAAAC
TTTAGTCATACAGGACCAACATTTCCAGTAGTACCTCCTTTCTTAAGTAGCATTGCTGGAGTCCCAACCACAGCAGCAGCCACAGCACCA
GTCCCTGCAACAAGCAGCCCTCCTAATGACATTTCCACATCAGTAATTCAGTCTGAGGTTACAGTGCCCACTGAAGAGGGGATTGCTGGA
GTTGCCACCAGCACAGGTGTGGTAACTTCAGGTGGTCTCCCCATACCACCTGTGTCTGAATCACCAGTACTTTCCAGCGTAGTTTCAAGT
ATCACAATACCTGCAGTTGTCTCAATATCTACTACATCCCCGTCACTTCAAGTCCCCACATCCACATCTGAGATCGTTGTTTCTAGTACA
GCACTGTATCCTTCAGTAACAGTTTCAGCAACTTCAGCCTCTGCAGGGGGCAGTACTGCTACCCCAGGTCCTAAGCCTCCAGCTGTAGTA
TCTCAGCAGGCAGCAGGCAGCACTACTGTGGGAGCCACATTAACATCAGTTTCTACCACCACTTCATTCCCAAGCACAGCTTCACAGCTG
TGCATTCAGCTTAGCAGCAGTACTTCTACTCCTACTTTAGCTGAAACCGTGGTAGTTAGCGCACACTCACTAGATAAGACATCTCATAGC
AGTACAACTGGATTGGCTTTCTCCCTCTCTGCACCATCTTCCTCTTCCTCTCCTGGAGCAGGAGTGTCTAGTTATATTTCTCAGCCTGGT
GGGCTGCATCCTTTGGTCATTCCATCAGTGATAGCTTCTACTCCTATTCTTCCCCAAGCAGCAGGACCTACTTCTACACCTTTATTACCC
CAAGTACCTAGTATCCCACCCTTGGTACAGCCTGTTGCCAATGTGCCTGCTGTACAGCAGACACTAATTCATAGTCAGCCTCAACCAGCT
TTGCTTCCCAACCAGCCCCATACTCATTGTCCTGAAGTAGATTCTGATACACAACCCAAAGCTCCTGGAATTGATGACATAAAGACTCTA
GAAGAAAAGCTGCGGTCTCTGTTCAGTGAACACAGCTCATCTGGAGCTCAGCATGCCTCTGTCTCACTGGAGACCTCACTAGTCATAGAG
AGCACTGTCACACCAGGCATCCCAACTACTGCTGTTGCACCAAGCAAACTCCTGACTTCTACCACAAGTACTTGCTTACCACCAACCAAT
TTACCACTAGGAACAGTTGCTTTGCCAGTTACACCAGTGGTCACACCTGGGCAAGTTTCTACCCCAGTCAGCACTACTACATCAGGAGTG
AAACCTGGAACTGCTCCCTCCAAGCCACCTCTAACTAAGGCTCCGGTGCTGCCAGTGGGTACTGAACTTCCAGCAGGTACTCTACCCAGC
GAGCAGCTGCCACCTTTTCCAGGACCTTCTCTAACCCAGTCCCAGCAACCTCTAGAGGATCTTGATGCTCAATTGAGAAGAACACTTAGT
CCAGAGATGATCACAGTGACTTCTGCGGTTGGTCCTGTGTCCATGGCGGCTCCAACAGCAATCACAGAAGCAGGAACACAGCCTCAGAAG
GTTTCTCAAGTCAAAGAAGGCCCTGTCCTAGCAACTAGTTCAGGAGCTGGTGTTTTTAAGATGGGACGATTTCAGGTTTCTGTTGCAGCA
GACGGTGCCCAGAAAGAGGGTAAAAATAAGTCAGAAGATGCAAAGTCTGTTCATTTTGAATCCAGCACCTCAGAGTCCTCAGTGCTATCA
AGTAGTAGTCCAGAGAGTACCTTGGTGAAACCAGAGCCGAATGGCATAACCATCCCTGGTATCTCTTCAGATGTGCCAGAGAGTGCCCAC
AAAACTACTGCCTCAGAGGCAAAGTCAGACACTGGGCAGCCTACCAAGGTTGGACGTTTTCAGGTGACAACTACAGCAAACAAAGTGGGT
CGTTTCTCTGTATCAAAAACTGAGGACAAGATCACTGACACAAAGAAAGAAGGACCAGTGGCATCTCCTCCTTTTATGGATTTGGAACAA
GCTGTTCTTCCTGCTGTGATACCAAAGAAAGAGAAGCCTGAACTGTCAGAGCCTTCACATCTAAATGGGCCGTCTTCTGACCCGGAGGCC
GCTTTTTTAAGTAGGGATGTGGATGATGGTTCCGGTAGTCCACACTCGCCCCATCAGCTGAGCTCAAAGAGCCTTCCTAGCCAGAATCTA
AGTCAAAGCCTTAGTAATTCATTTAACTCCTCTTACATGAGTAGCGACAATGAGTCAGATATCGAAGATGAAGACTTAAAGTTAGAGCTG
CGACGACTACGAGATAAACATCTCAAAGAGATTCAGGACCTGCAGAGTCGCCAGAAGCATGAAATTGAATCTTTGTATACCAAACTGGGC
AAGGTGCCCCCTGCTGTTATTATTCCCCCAGCTGCTCCCCTTTCAGGGAGAAGACGACGACCCACTAAAAGCAAAGGCAGCAAATCTAGT
CGAAGCAGTTCCTTGGGGAATAAAAGCCCCCAGCTTTCAGGTAACCTGTCTGGTCAGAGTGCAGCTTCAGTCTTGCACCCCCAGCAGACC
CTCCACCCTCCTGGCAACATCCCAGAGTCCGGGCAGAATCAGCTGTTACAGCCCCTTAAGCCATCTCCCTCCAGTGACAACCTCTATTCA
GCCTTCACCAGTGATGGTGCCATTTCAGTACCAAGCCTTTCTGCTCCAGGTCAAGGAACCAGCAGCACAAACACTGTTGGGGCAACAGTG
AACAGCCAAGCCGCCCAAGCTCAGCCTCCTGCCATGACGTCCAGCAGGAAGGGCACATTCACAGATGACTTGCACAAGTTGGTAGACAAT
TGGGCCCGAGATGCCATGAATCTCTCAGGCAGGAGAGGAAGCAAAGGGCACATGAATTACGAGGGCCCTGGAATGGCAAGGAAGTTCTCT
GCACCTGGGCAACTGTGCATCTCCATGACCTCGAACCTGGGTGGCTCTGCCCCCATCTCTGCAGCATCAGCTACCTCTCTAGGTCACTTC
ACCAAGTCTATGTGCCCCCCACAGCAGTATGGCTTTCCAGCTACCCCATTTGGCGCTCAATGGAGTGGGACGGGTGGCCCAGCACCACAG
CCACTTGGCCAGTTCCAACCTGTGGGAACTGCCTCCTTGCAGAATTTCAACATCAGCAATTTGCAGAAATCCATCAGCAACCCCCCAGGC
TCCAACCTGCGGACCACTTAGACCTAGAGACATTAACTGAATAGATCTGGGGGCAGGAGATGGAATGCTGAGGGGGTGGGTGGGGGTGGG
AAGTAGCCTATATACTAACTACTAGTGCTGCATTTAACTGGTTATTTCTTGCCAGAGGGGAATGTTTTTAATACTGCATTGAGCCCTCAG
AATGGAGAGTCTCCCCCGCTCCAGTTATTGGAATGGGAGAGGAAGGAAAGAACAGCTTTTTTGTCAAGGGGCAGCTTCAGACCATGCTTT
CCTGTTTATCTATACTCAGTAATGAGGATGAGGGCTAGGAAAGTCTTGTTCATAAGGAAGCTGGAGAACTCAATGTAAAATCAAACCCAT
CTGTAATTTCGAGTGGGTGGAGCTCTTGCTTTTGGTACATGCCCTGAATCCCTCACTCCCTCAAGAATCCGAACCACAGGACAAAAACCA
CCTACTGGGCTCTCTCCTACCCTGCCCTCCTCCCTTTTTTTTACCCCTCTCTTTTTTATTTTTTCTTTGCTCTTTAGAACCCAGTGAAAA
ATACCAGGGTACTGGGGTGCAACTCTTTCTTATGATAGGTCATTAGTGCTTTAAGCAAAAGATATTAGCAGCTTTGACTGCAGCATTAGC
AATTAGGAAAAAAAAAAAATTAAGTTCCCTGCGGACATGTAACTTTGCCATCAGTTTTGATGTGGAAACACTGTGATATATAAAATGTTG
TTGGACAACAGTAGTTTTAAGAGTAAAATATGAAACGTTTAAAAAGTTCCAAAAAAAGCTAGCTCTGTCCTTTACTTATTGAGACACTTT
AACTTTTTCCTTTGTATTTCCATTGTATTAGATAAATAAATGTGAATGTAAAATTGTATAAATTACTGTACTTGAATACTTCTGTTTCCC
AGTGTTGCTTGCTGGACATTTTAGTGCCTTGGACTTCTATTGCTTCTGCCATTAGCATCAACTTACCAGACCCCAGATCAATAAAGGGCA
TGTGGAAGGAAATCGTAGGTCCATGTGACCCCAGCAGTCCAGCAGTGGTTATGCCAAAGGGAAATTGAAAAAGTATTTTTTTAAGTCATT
CAACAACTTTGTCTAGAGCAGGTGTAAGATGAGTAGGGTGGGAAGTTAGGTTGGCATCAGTGGTTAAAAACAGAAAGTTCTGTTTCGGGA
ATAGTGAGGAGGGGGTGTTGTAACAAAATTGGACAACTTAAAAGAATGGTGTGTGCTGGGTGAAAGACAAAGACTAAAGAATGAGGAAAC
AAACGTGATGCCTGGCCAGTGACTGTCATATAAACCTTTCTTATTTGAGCTAGGCTTGAACAGACGTGACCTAGAAGAAACTGAACATAA
AGAGAAGGGGGTGGGGGGCTAGTTTTCAAGTTGGGGAACCTGATAGTGAAAAGTCACAGATGGAGAAAATTGCTCTCAGAAAAACTGTTT
GGATTGCTTTCCTCTTGTTGCACATGTACCATGCATTTCTCAGCTTGGGGTACTACATTTTGTGGAAAGTTAATCTATCTATCTTTCCAC
ATCTGAATTAATCATTCTAGGAAAGAATACTTATTCCTACTCATTTCCTTTATGATGTCCAAATGGTTGCAGGATCATAATCTATTGTGC
CACCTTTATTTCTAGAAGTACAACTAATATGTTCACATTTTCAAATAAATAATACTCCCCGTAAGTAATAACTGCAACCAATCAGTGTTA
TTCAGTGCTATGCCTCCTTGTAATGGGTAGTTATTAATTATTTTCAGAGCTTTCCGGAAATACTGTCCTAACTGGCTATGTTTAGGATCT
TTGTTATCTCTGAAGACAAAGAAAGAAGCTAGGACTCTTAATTTTGGGGTGCTTCTTGACTCTTAGTTGGGAAACTGAAAATATTTCCAA
CCTTTTACCCACGTCAATGGCATATTCTGGGAATCACCACCACCACCACCACTACCACAGAAAGAGGCTGGAGGCTCCTGTACCCTGTTC
ATTCCTTAAGGGCCCTGCTTCCCTTAGTAAGTAAGTAAGTTGGTCTACGGCCCTAAATATGCAAATGAGAGCTGAAGGTTTTTAAAAGGT
AGAAAGGAAAAGGGCAAGGGCTTCCACCCCTGCTTTAAAATGATTTATTTATTCTCTGCTTGTATTTCTTGTGGAGAGAGTAAGGATAGA
ACCAACAAGGGGCTGAGTAGCTGAGAAAGGGGCCACCCAAGAGTGAAACATACTTTATACCAGAGGAGCAGTGGAGCCTCATGCAGCACA
TTATCATTTGTTATTTGGGTTTAATAATAATTTTGACATCTTTTCACTCATACACAAAAAAAGTCAGAACTGGTGTTATTTACTGTTGAT
TTCATCCTCCTGTGTATGAAATAACAAGCCTAGAGGAATGAACTAGTGCTACTGAACTGTTTAAATTATTTTTGTGTTAATAGTACACTT
TGAGTATCTTTTTCCACATTAAAAACTTTCTGAATTATAAATGTTTTCCTTACATTATTTAACAATGTACACTGTTAAAAATAAAAATAA

>38120_38120_5_HUWE1-WNK1_HUWE1_chrX_53619357_ENST00000262854_WNK1_chr12_992560_ENST00000535572_length(amino acids)=2547AA_BP=1326
MKIEIMKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPE
REQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKEN
GFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAH
GFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASY
HGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMA
AFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGS
LPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQ
PFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPP
PRSNHAAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTI
LGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHA
LTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQKLVPKDEKAGTTQ
GGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLAPMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCV
GSPVRQRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKYPYHLMLQKFLCSGGHNA
LFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKN
LWNRKPLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQVNNDFILAIERESFVDQVREI
IEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRFIVSPVPESRLRESKVF
PSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSHTGPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPN
DISTSVIQSEVTVPTEEGIAGVATSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSEIVVSSTALYPSVTVS
ATSASAGGSTATPGPKPPAVVSQQAAGSTTVGATLTSVSTTTSFPSTASQLCIQLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSL
SAPSSSSSPGAGVSSYISQPGGLHPLVIPSVIASTPILPQAAGPTSTPLLPQVPSIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTH
CPEVDSDTQPKAPGIDDIKTLEEKLRSLFSEHSSSGAQHASVSLETSLVIESTVTPGIPTTAVAPSKLLTSTTSTCLPPTNLPLGTVALP
VTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPFPGPSLTQSQQPLEDLDAQLRRTLSPEMITVTSA
VGPVSMAAPTAITEAGTQPQKVSQVKEGPVLATSSGAGVFKMGRFQVSVAADGAQKEGKNKSEDAKSVHFESSTSESSVLSSSSPESTLV
KPEPNGITIPGISSDVPESAHKTTASEAKSDTGQPTKVGRFQVTTTANKVGRFSVSKTEDKITDTKKEGPVASPPFMDLEQAVLPAVIPK
KEKPELSEPSHLNGPSSDPEAAFLSRDVDDGSGSPHSPHQLSSKSLPSQNLSQSLSNSFNSSYMSSDNESDIEDEDLKLELRRLRDKHLK
EIQDLQSRQKHEIESLYTKLGKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQSAASVLHPQQTLHPPGNIPE
SGQNQLLQPLKPSPSSDNLYSAFTSDGAISVPSLSAPGQGTSSTNTVGATVNSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLS
GRRGSKGHMNYEGPGMARKFSAPGQLCISMTSNLGGSAPISAASATSLGHFTKSMCPPQQYGFPATPFGAQWSGTGGPAPQPLGQFQPVG

--------------------------------------------------------------
>38120_38120_6_HUWE1-WNK1_HUWE1_chrX_53619357_ENST00000262854_WNK1_chr12_992560_ENST00000537687_length(transcript)=10694nt_BP=4374nt
GAGGCTTTCGACTGAGGGCTAGCGAGGGGAGCACGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGGAGCAGGGCTGAAGCAGG
GCCGCGGACCCCGCACGCTCCTGCGGGCCCCGCGGAGCCATTGCGGCCGAGGCCTCGGCAGGCGCCAGCGGAGAGCTAGCCGCATCTTCG
GGGGCAGCCCGGCAGCTGCCGGCGGCGCGGCGAGAGAGCGGCTGACAGAGGGGATGCGAGGTCCTCCAGCAGCCTGACCTGAGTGGGTTA
GTGATCCAGAGAAACCAGCAGGCCAACTTGGTCAGGAAGGTTCGGGAAGCTGTTGGAGCAGTGTGGGGAATTTCCCACCAGGATGAGTAT
GATTGGCTGTGATTTTAGATCGTAAAGCTGAAAATTGAAATCATGAAAGTAGACAGGACTAAACTGAAGAAGACACCTACTGAGGCTCCT
GCAGACTGCAGAGCCTTAATAGACAAACTCAAAGTTTGTAATGATGAGCAACTTCTCTTGGAACTGCAGCAGATCAAAACATGGAACATT
GGAAAGTGCGAGTTATATCACTGGGTGGACCTGTTGGACCGCTTCGATGGAATACTGGCAGATGCTGGACAGACAGTGGAGAATATGTCA
TGGATGCTCGTATGTGATAGGCCAGAAAGAGAGCAACTGAAAATGCTTCTCTTGGCTGTGTTGAACTTCACAGCCTTGCTCATTGAGTAC
AGCTTTTCCCGGCATCTGTACAGTTCCATAGAGCATTTGACAACTTTATTGGCTTCCTCTGATATGCAAGTGGTGCTGGCAGTCCTCAAT
CTCCTATATGTATTTAGCAAAAGATCAAACTACATCACTCGTCTGGGATCTGACAAGAGGACCCCGCTGCTAACTCGGCTACAACATTTG
GCAGAGAGCTGGGGTGGAAAGGAGAATGGCTTTGGACTTGCAGAATGTTGCAGAGACTTGCATATGATGAAATATCCACCCAGTGCAACT
ACACTACACTTTGAATTCTATGCAGATCCTGGGGCCGAGGTCAAAATTGAGAAAAGGACAACTAGTAACACACTACATTATATTCACATA
GAGCAACTTGACAAGATTTCAGAAAGCCCTTCTGAAATCATGGAATCTCTTACCAAAATGTACAGCATTCCTAAGGATAAGCAGATGCTG
TTATTTACACACATACGACTGGCCCATGGCTTTTCTAATCACAGGAAGCGATTGCAGGCAGTTCAGGCCAGACTGCATGCAATATCTATA
TTAGTGTATTCCAATGCCTTGCAGGAATCAGCAAACAGTATCTTGTATAATGGCTTGATAGAGGAGTTGGTAGATGTCCTTCAGATAACG
GATAAGCAGCTTATGGAGATTAAAGCAGCTTCTTTACGAACATTAACATCAATTGTCCACTTGGAGAGAACTCCCAAACTCAGCAGTATT
ATTGACTGTACTGGAACTGCCTCCTACCATGGATTTTTGCCAGTGCTTGTAAGGAACTGTATCCAGGCCATGATTGATCCTTCCATGGAT
CCATACCCTCACCAGTTTGCCACTGCTCTCTTCTCTTTTTTATACCATCTGGCCAGCTACGATGCTGGTGGTGAAGCCTTGGTCTCCTGT
GGAATGATGGAAGCCTTATTGAAGGTCATAAAGTTTCTTGGCGATGAACAGGACCAGATAACATTTGTCACCAGAGCCGTCAGAGTGGTT
GACCTTATCACCAACCTGGATATGGCAGCTTTTCAATCCCATAGTGGACTTTCTATCTTCATTTATAGACTTGAGCATGAAGTAGATTTG
TGCCGAAAAGAATGTCCGTTTGTGATCAAGCCAAAGATCCAGAGACCCAATACTACACAAGAAGGAGAGGAAATGGAAACTGATATGGAT
GGAGTCCAGTGTATTCCACAACGAGCAGCACTTCTGAAATCCATGTTGAATTTCCTCAAGAAGGCCATCCAAGACCCTGCTTTCTCAGAT
GGCATACGACATGTGATGGATGGTTCTCTGCCTACCTCCCTGAAACACATCATCAGCAATGCAGAATACTATGGCCCATCACTCTTCCTC
CTAGCTACTGAAGTGGTGACTGTGTTTGTATTTCAAGAACCATCACTGCTCTCCTCACTCCAGGACAATGGATTGACAGATGTCATGCTG
CATGCACTGCTTATCAAAGATGTTCCTGCTACCCGTGAAGTCCTTGGCTCCCTCCCAAATGTATTCAGTGCACTCTGTTTGAATGCCCGA
GGTCTTCAGTCTTTTGTTCAGTGTCAGCCTTTTGAACGCCTCTTCAAAGTTCTTCTGTCTCCAGATTACCTCCCAGCCATGCGGAGGAGG
AGAAGTTCTGATCCCCTTGGGGATACTGCATCCAACCTGGGGAGTGCTGTCGATGAGCTCATGAGACATCAGCCCACCCTTAAAACAGAT
GCAACGACTGCCATCATCAAGTTACTTGAAGAAATCTGTAATCTTGGAAGGGACCCCAAATACATCTGTCAGAAGCCATCAATCCAGAAG
GCAGATGGCACTGCCACTGCTCCTCCCCCAAGGTCTAATCATGCCGCAGAAGAAGCCTCTAGTGAGGATGAGGAGGAAGAGGAAGTACAG
GCCATGCAGAGCTTTAATTCTACCCAGCAAAATGAAACTGAGCCTAATCAGCAGGTTGTTGGTACAGAGGAACGTATTCCTATTCCCCTC
ATGGATTACATCCTTAATGTGATGAAATTTGTGGAATCTATTCTGAGCAACAATACAACAGATGACCACTGCCAGGAATTTGTGAATCAG
AAAGGACTGTTGCCTTTGGTTACCATTTTGGGTCTTCCCAATCTGCCCATTGACTTTCCCACATCTGCTGCCTGTCAGGCTGTTGCAGGT
GTCTGCAAATCCATATTGACACTGTCACATGAACCCAAAGTCCTTCAAGAGGGTCTCCTTCAGTTGGACTCCATCCTCTCCTCCCTGGAG
CCCTTACACCGCCCCATTGAATCCCCTGGGGGCTCAGTGTTGTTGCGAGAACTGGCTTGCGCAGGCAATGTTGCTGATGCTACCCTCTCA
GCCCAGGCCACACCTCTGCTGCATGCACTCACTGCTGCCCATGCCTACATCATGATGTTTGTTCATACTTGCAGAGTTGGACAGAGTGAA
ATTCGTTCCATCTCCGTAAACCAGTGGGGCTCTCAATTGGGTCTGAGTGTTTTGAGCAAGCTGAGCCAGTTATACTGTTCCCTGGTGTGG
GAAAGCACTGTCCTCCTCTCTCTGTGTACCCCAAACAGCCTACCATCTGGGTGTGAATTTGGCCAGGCAGATATGCAGAAACTGGTTCCA
AAGGATGAGAAGGCAGGTACGACCCAGGGCGGAAAAAGATCAGATGGGGAACAGGATGGAGCAGCTGGAAGTATGGATGCTTCTACCCAG
GGCTTATTAGAAGGCATTGGGCTAGATGGTGACACATTGGCTCCCATGGAGACAGATGAACCTACTGCTTCAGACTCTAAGGGCAAATCT
AAAATCACACCAGCAATGGCTGCCAGAATTAAGCAAATCAAGCCTTTGTTATCAGCTTCCTCCAGATTAGGCCGAGCACTTGCTGAGCTA
TTTGGACTTCTTGTTAAACTTTGTGTGGGATCTCCTGTCCGCCAGAGAAGGAGCCATCATGCTGCCAGCACCACTACAGCACCGACACCT
GCCGCGCGATCAACAGCCTCAGCTCTCACTAAGCTCTTGACTAAGGGGTTATCTTGGCAGCCCCCACCATATACACCTACTCCCCGATTC
AGGCTGACATTCTTCATCTGTTCAGTTGGTTTCACATCCCCAATGCTGTTTGATGAGAGGAAGTATCCCTACCACCTCATGCTGCAAAAA
TTTCTCTGCTCCGGAGGCCACAATGCTCTTTTTGAAACTTTCAACTGGGCTCTGTCCATGGGAGGTAAAGTTCCTGTTTCTGAGGGATTG
GAACACTCAGACTTGCCTGATGGCACAGGAGAATTCCTAGATGCCTGGCTTATGCTGGTGGAGAAGATGGTGAATCCCACCACGGTGCTT
GAATCTCCACATTCGCTGCCTGCCAAATTGCCTGGAGGTGTCCAGAACTTTCCCCAGTTCAGTGCACTGCGCTTCCTTGTGGTAACTCAG
AAAGCAGCCTTTACTTGCATCAAAAACTTATGGAACCGGAAACCCCTGAAGGTATATGGTGGACGAATGGCTGAATCGATGCTGGCCATT
CTATGCCACATCCTCCGAGGAGAACCTGTGATTCGAGAGAGACTAAGCAAGGAGAAGGAGGGGTCTCGAGGAGAAGAGGATACAGGGCAA
GAGGAAGGTGGCTCCCGCCGGGAACCTCAAGTCAACCAGCAACAACTGCAACAGGTGAACAATGACTTTATTCTAGCAATAGAGAGAGAG
TCGTTTGTGGATCAAGTGCGAGAAATTATTGAAAAAGCTGATGAAATGCTCAGTGAGGATGTCAGTGTGGAACCAGAGGGTGATCAGGGA
TTGGAGAGTCTACAAGGAAAGGATGACTATGGCTTTTCAGGTTCTCAGAAATTGGAAGGAGAGTTCAAACAACCAATTCCTGCGTCTTCC
ATGCCACAGCAAATAGGCATTCCTACCAGTTCTTTAACTCAAGTTGTTCATTCTGCGGGAAGGCGGTTTATAGTGAGTCCTGTGCCAGAA
AGCCGATTACGAGAATCAAAAGTTTTCCCCAGTGAAATAACAGATACAGTTGCTGCCTCTACAGCTCAGAGCCCTGGAATGAACTTGTCT
CACTCTGCATCATCCCTTAGTCTACAACAGGCCTTTTCTGAACTTAGACGTGCCCAAATGACAGAAGGACCCAACACAGCACCTCCAAAC
TTTAGTCATACAGGACCAACATTTCCAGTAGTACCTCCTTTCTTAAGTAGCATTGCTGGAGTCCCAACCACAGCAGCAGCCACAGCACCA
GTCCCTGCAACAAGCAGCCCTCCTAATGACATTTCCACATCAGTAATTCAGTCTGAGGTTACAGTGCCCACTGAAGAGGGGATTGCTGGA
GTTGCCACCAGCACAGGTGTGGTAACTTCAGGTGGTCTCCCCATACCACCTGTGTCTGAATCACCAGTACTTTCCAGCGTAGTTTCAAGT
ATCACAATACCTGCAGTTGTCTCAATATCTACTACATCCCCGTCACTTCAAGTCCCCACATCCACATCTGAGATCGTTGTTTCTAGTACA
GCACTGTATCCTTCAGTAACAGTTTCAGCAACTTCAGCCTCTGCAGGGGGCAGTACTGCTACCCCAGGTCCTAAGCCTCCAGCTGTAGTA
TCTCAGCAGGCAGCAGGCAGCACTACTGTGGGAGCCACATTAACATCAGTTTCTACCACCACTTCATTCCCAAGCACAGCTTCACAGCTG
TGCATTCAGCTTAGCAGCAGTACTTCTACTCCTACTTTAGCTGAAACCGTGGTAGTTAGCGCACACTCACTAGATAAGACATCTCATAGC
AGTACAACTGGATTGGCTTTCTCCCTCTCTGCACCATCTTCCTCTTCCTCTCCTGGAGCAGGAGTGTCTAGTTATATTTCTCAGCCTGGT
GGGCTGCATCCTTTGGTCATTCCATCAGTGATAGCTTCTACTCCTATTCTTCCCCAAGCAGCAGGACCTACTTCTACACCTTTATTACCC
CAAGTACCTAGTATCCCACCCTTGGTACAGCCTGTTGCCAATGTGCCTGCTGTACAGCAGACACTAATTCATAGTCAGCCTCAACCAGCT
TTGCTTCCCAACCAGCCCCATACTCATTGTCCTGAAGTAGATTCTGATACACAACCCAAAGCTCCTGGAATTGATGACATAAAGACTCTA
GAAGAAAAGCTGCGGTCTCTGTTCAGTGAACACAGCTCATCTGGAGCTCAGCATGCCTCTGTCTCACTGGAGACCTCACTAGTCATAGAG
AGCACTGTCACACCAGGCATCCCAACTACTGCTGTTGCACCAAGCAAACTCCTGACTTCTACCACAAGTACTTGCTTACCACCAACCAAT
TTACCACTAGGAACAGTTGCTTTGCCAGTTACACCAGTGGTCACACCTGGGCAAGTTTCTACCCCAGTCAGCACTACTACATCAGGAGTG
AAACCTGGAACTGCTCCCTCCAAGCCACCTCTAACTAAGGCTCCGGTGCTGCCAGTGGGTACTGAACTTCCAGCAGGTACTCTACCCAGC
GAGCAGCTGCCACCTTTTCCAGGACCTTCTCTAACCCAGTCCCAGCAACCTCTAGAGGATCTTGATGCTCAATTGAGAAGAACACTTAGT
CCAGAGATGATCACAGTGACTTCTGCGGTTGGTCCTGTGTCCATGGCGGCTCCAACAGCAATCACAGAAGCAGGAACACAGCCTCAGAAG
GGTGTTTCTCAAGTCAAAGAAGGCCCTGTCCTAGCAACTAGTTCAGGAGCTGGTGTTTTTAAGATGGGACGATTTCAGGTTTCTGTTGCA
GCAGACGGTGCCCAGAAAGAGGGTAAAAATAAGTCAGAAGATGCAAAGTCTGTTCATTTTGAATCCAGCACCTCAGAGTCCTCAGTGCTA
TCAAGTAGTAGTCCAGAGAGTACCTTGGTGAAACCAGAGCCGAATGGCATAACCATCCCTGGTATCTCTTCAGATGTGCCAGAGAGTGCC
CACAAAACTACTGCCTCAGAGGCAAAGTCAGACACTGGGCAGCCTACCAAGGTTGGACGTTTTCAGGTGACAACTACAGCAAACAAAGTG
GGTCGTTTCTCTGTATCAAAAACTGAGGACAAGATCACTGACACAAAGAAAGAAGGACCAGTGGCATCTCCTCCTTTTATGGATTTGGAA
CAAGCTGTTCTTCCTGCTGTGATACCAAAGAAAGAGAAGCCTGAACTGTCAGAGCCTTCACATCTAAATGGGCCGTCTTCTGACCCGGAG
GCCGCTTTTTTAAGTAGGGATGTGGATGATGGTTCCGGTAGTCCACACTCGCCCCATCAGCTGAGCTCAAAGAGCCTTCCTAGCCAGAAT
CTAAGTCAAAGCCTTAGTAATTCATTTAACTCCTCTTACATGAGTAGCGACAATGAGTCAGATATCGAAGATGAAGACTTAAAGTTAGAG
CTGCGACGACTACGAGATAAACATCTCAAAGAGATTCAGGACCTGCAGAGTCGCCAGAAGCATGAAATTGAATCTTTGTATACCAAACTG
GGCAAGGTGCCCCCTGCTGTTATTATTCCCCCAGCTGCTCCCCTTTCAGGGAGAAGACGACGACCCACTAAAAGCAAAGGCAGCAAATCT
AGTCGAAGCAGTTCCTTGGGGAATAAAAGCCCCCAGCTTTCAGGTAACCTGTCTGGTCAGAGTGCAGCTTCAGTCTTGCACCCCCAGCAG
ACCCTCCACCCTCCTGGCAACATCCCAGAGTCCGGGCAGAATCAGCTGTTACAGCCCCTTAAGCCATCTCCCTCCAGTGACAACCTCTAT
TCAGCCTTCACCAGTGATGGTGCCATTTCAGTACCAAGCCTTTCTGCTCCAGGTCAAGGAACCAGCAGCACAAACACTGTTGGGGCAACA
GTGAACAGCCAAGCCGCCCAAGCTCAGCCTCCTGCCATGACGTCCAGCAGGAAGGGCACATTCACAGATGACTTGCACAAGTTGGTAGAC
AATTGGGCCCGAGATGCCATGAATCTCTCAGGCAGGAGAGGAAGCAAAGGGCACATGAATTACGAGGGCCCTGGAATGGCAAGGAAGTTC
TCTGCACCTGGGCAACTGTGCATCTCCATGACCTCGAACCTGGGTGGCTCTGCCCCCATCTCTGCAGCATCAGCTACCTCTCTAGGTCAC
TTCACCAAGTCTATGTGCCCCCCACAGCAGTATGGCTTTCCAGCTACCCCATTTGGCGCTCAATGGAGTGGGACGGGTGGCCCAGCACCA
CAGCCACTTGGCCAGTTCCAACCTGTGGGAACTGCCTCCTTGCAGAATTTCAACATCAGCAATTTGCAGAAATCCATCAGCAACCCCCCA
GGCTCCAACCTGCGGACCACTTAGACCTAGAGACATTAACTGAATAGATCTGGGGGCAGGAGATGGAATGCTGAGGGGGTGGGTGGGGGT
GGGAAGTAGCCTATATACTAACTACTAGTGCTGCATTTAACTGGTTATTTCTTGCCAGAGGGGAATGTTTTTAATACTGCATTGAGCCCT
CAGAATGGAGAGTCTCCCCCGCTCCAGTTATTGGAATGGGAGAGGAAGGAAAGAACAGCTTTTTTGTCAAGGGGCAGCTTCAGACCATGC
TTTCCTGTTTATCTATACTCAGTAATGAGGATGAGGGCTAGGAAAGTCTTGTTCATAAGGAAGCTGGAGAACTCAATGTAAAATCAAACC
CATCTGTAATTTCGAGTGGGTGGAGCTCTTGCTTTTGGTACATGCCCTGAATCCCTCACTCCCTCAAGAATCCGAACCACAGGACAAAAA
CCACCTACTGGGCTCTCTCCTACCCTGCCCTCCTCCCTTTTTTTTACCCCTCTCTTTTTTATTTTTTCTTTGCTCTTTAGAACCCAGTGA
AAAATACCAGGGTACTGGGGTGCAACTCTTTCTTATGATAGGTCATTAGTGCTTTAAGCAAAAGATATTAGCAGCTTTGACTGCAGCATT
AGCAATTAGGAAAAAAAAAAAATTAAGTTCCCTGCGGACATGTAACTTTGCCATCAGTTTTGATGTGGAAACACTGTGATATATAAAATG
TTGTTGGACAACAGTAGTTTTAAGAGTAAAATATGAAACGTTTAAAAAGTTCCAAAAAAAGCTAGCTCTGTCCTTTACTTATTGAGACAC
TTTAACTTTTTCCTTTGTATTTCCATTGTATTAGATAAATAAATGTGAATGTAAAATTGTATAAATTACTGTACTTGAATACTTCTGTTT
CCCAGTGTTGCTTGCTGGACATTTTAGTGCCTTGGACTTCTATTGCTTCTGCCATTAGCATCAACTTACCAGACCCCAGATCAATAAAGG
GCATGTGGAAGGAAATCGTAGGTCCATGTGACCCCAGCAGTCCAGCAGTGGTTATGCCAAAGGGAAATTGAAAAAGTATTTTTTTAAGTC
ATTCAACAACTTTGTCTAGAGCAGGTGTAAGATGAGTAGGGTGGGAAGTTAGGTTGGCATCAGTGGTTAAAAACAGAAAGTTCTGTTTCG
GGAATAGTGAGGAGGGGGTGTTGTAACAAAATTGGACAACTTAAAAGAATGGTGTGTGCTGGGTGAAAGACAAAGACTAAAGAATGAGGA
AACAAACGTGATGCCTGGCCAGTGACTGTCATATAAACCTTTCTTATTTGAGCTAGGCTTGAACAGACGTGACCTAGAAGAAACTGAACA
TAAAGAGAAGGGGGTGGGGGGCTAGTTTTCAAGTTGGGGAACCTGATAGTGAAAAGTCACAGATGGAGAAAATTGCTCTCAGAAAAACTG
TTTGGATTGCTTTCCTCTTGTTGCACATGTACCATGCATTTCTCAGCTTGGGGTACTACATTTTGTGGAAAGTTAATCTATCTATCTTTC
CACATCTGAATTAATCATTCTAGGAAAGAATACTTATTCCTACTCATTTCCTTTATGATGTCCAAATGGTTGCAGGATCATAATCTATTG
TGCCACCTTTATTTCTAGAAGTACAACTAATATGTTCACATTTTCAAATAAATAATACTCCCCGTAAGTAATAACTGCAACCAATCAGTG
TTATTCAGTGCTATGCCTCCTTGTAATGGGTAGTTATTAATTATTTTCAGAGCTTTCCGGAAATACTGTCCTAACTGGCTATGTTTAGGA
TCTTTGTTATCTCTGAAGACAAAGAAAGAAGCTAGGACTCTTAATTTTGGGGTGCTTCTTGACTCTTAGTTGGGAAACTGAAAATATTTC
CAACCTTTTACCCACGTCAATGGCATATTCTGGGAATCACCACCACCACCACCACTACCACAGAAAGAGGCTGGAGGCTCCTGTACCCTG
TTCATTCCTTAAGGGCCCTGCTTCCCTTAGTAAGTAAGTAAGTTGGTCTACGGCCCTAAATATGCAAATGAGAGCTGAAGGTTTTTAAAA
GGTAGAAAGGAAAAGGGCAAGGGCTTCCACCCCTGCTTTAAAATGATTTATTTATTCTCTGCTTGTATTTCTTGTGGAGAGAGTAAGGAT
AGAACCAACAAGGGGCTGAGTAGCTGAGAAAGGGGCCACCCAAGAGTGAAACATACTTTATACCAGAGGAGCAGTGGAGCCTCATGCAGC
ACATTATCATTTGTTATTTGGGTTTAATAATAATTTTGACATCTTTTCACTCATACACAAAAAAAGTCAGAACTGGTGTTATTTACTGTT
GATTTCATCCTCCTGTGTATGAAATAACAAGCCTAGAGGAATGAACTAGTGCTACTGAACTGTTTAAATTATTTTTGTGTTAATAGTACA
CTTTGAGTATCTTTTTCCACATTAAAAACTTTCTGAATTATAAATGTTTTCCTTACATTATTTAACAATGTACACTGTTAAAAATAAAAA
TAAAAATTCAAACTTTGGGGGTTTCTCAGCAGCCGTTAATTGTACATTTTGCACTAACTCTGGGTGTTGCGCTTCTTGTAAGATTGCGCT

>38120_38120_6_HUWE1-WNK1_HUWE1_chrX_53619357_ENST00000262854_WNK1_chr12_992560_ENST00000537687_length(amino acids)=2548AA_BP=1326
MKIEIMKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPE
REQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKEN
GFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAH
GFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASY
HGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMA
AFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGS
LPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQ
PFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPP
PRSNHAAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTI
LGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHA
LTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQKLVPKDEKAGTTQ
GGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLAPMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCV
GSPVRQRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKYPYHLMLQKFLCSGGHNA
LFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKN
LWNRKPLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQVNNDFILAIERESFVDQVREI
IEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRFIVSPVPESRLRESKVF
PSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSHTGPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPN
DISTSVIQSEVTVPTEEGIAGVATSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSEIVVSSTALYPSVTVS
ATSASAGGSTATPGPKPPAVVSQQAAGSTTVGATLTSVSTTTSFPSTASQLCIQLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSL
SAPSSSSSPGAGVSSYISQPGGLHPLVIPSVIASTPILPQAAGPTSTPLLPQVPSIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTH
CPEVDSDTQPKAPGIDDIKTLEEKLRSLFSEHSSSGAQHASVSLETSLVIESTVTPGIPTTAVAPSKLLTSTTSTCLPPTNLPLGTVALP
VTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPFPGPSLTQSQQPLEDLDAQLRRTLSPEMITVTSA
VGPVSMAAPTAITEAGTQPQKGVSQVKEGPVLATSSGAGVFKMGRFQVSVAADGAQKEGKNKSEDAKSVHFESSTSESSVLSSSSPESTL
VKPEPNGITIPGISSDVPESAHKTTASEAKSDTGQPTKVGRFQVTTTANKVGRFSVSKTEDKITDTKKEGPVASPPFMDLEQAVLPAVIP
KKEKPELSEPSHLNGPSSDPEAAFLSRDVDDGSGSPHSPHQLSSKSLPSQNLSQSLSNSFNSSYMSSDNESDIEDEDLKLELRRLRDKHL
KEIQDLQSRQKHEIESLYTKLGKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQSAASVLHPQQTLHPPGNIP
ESGQNQLLQPLKPSPSSDNLYSAFTSDGAISVPSLSAPGQGTSSTNTVGATVNSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNL
SGRRGSKGHMNYEGPGMARKFSAPGQLCISMTSNLGGSAPISAASATSLGHFTKSMCPPQQYGFPATPFGAQWSGTGGPAPQPLGQFQPV

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Fusion Gene PPI Analysis for HUWE1-WNK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HUWE1-WNK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HUWE1-WNK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource