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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HYDIN-FAM91A1 (FusionGDB2 ID:38137)

Fusion Gene Summary for HYDIN-FAM91A1

check button Fusion gene summary
Fusion gene informationFusion gene name: HYDIN-FAM91A1
Fusion gene ID: 38137
HgeneTgene
Gene symbol

HYDIN

FAM91A1

Gene ID

54768

157769

Gene nameHYDIN axonemal central pair apparatus proteinfamily with sequence similarity 91 member A1
SynonymsCILD5|HYDIN1|HYDIN2|PPP1R31-
Cytomap

16q22.2

8q24.13

Type of geneprotein-codingprotein-coding
Descriptionhydrocephalus-inducing protein homologprotein phosphatase 1, regulatory subunit 31protein FAM91A1skeletal muscle cells re-entry induced
Modification date2020031320200313
UniProtAcc

Q4G0P3

Q658Y4

Ensembl transtripts involved in fusion geneENST00000321489, ENST00000393550, 
ENST00000393567, ENST00000448089, 
ENST00000448691, ENST00000288168, 
ENST00000538248, ENST00000541601, 
ENST00000543639, 		ENST00000334705, 
ENST00000521166, 
Fusion gene scores* DoF score3 X 4 X 3=363 X 3 X 3=27
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HYDIN [Title/Abstract] AND FAM91A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHYDIN(71163543)-FAM91A1(124786320), # samples:1
Anticipated loss of major functional domain due to fusion event.HYDIN-FAM91A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFAM91A1

GO:0006886

intracellular protein transport

29426865

TgeneFAM91A1

GO:0099041

vesicle tethering to Golgi

29426865


check buttonFusion gene breakpoints across HYDIN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM91A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-WR-A838-01AHYDINchr16

71163543

-FAM91A1chr8

124786320

+


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Fusion Gene ORF analysis for HYDIN-FAM91A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000321489ENST00000334705HYDINchr16

71163543

-FAM91A1chr8

124786320

+
Frame-shiftENST00000321489ENST00000521166HYDINchr16

71163543

-FAM91A1chr8

124786320

+
Frame-shiftENST00000393550ENST00000334705HYDINchr16

71163543

-FAM91A1chr8

124786320

+
Frame-shiftENST00000393550ENST00000521166HYDINchr16

71163543

-FAM91A1chr8

124786320

+
Frame-shiftENST00000393567ENST00000334705HYDINchr16

71163543

-FAM91A1chr8

124786320

+
Frame-shiftENST00000393567ENST00000521166HYDINchr16

71163543

-FAM91A1chr8

124786320

+
Frame-shiftENST00000448089ENST00000334705HYDINchr16

71163543

-FAM91A1chr8

124786320

+
Frame-shiftENST00000448089ENST00000521166HYDINchr16

71163543

-FAM91A1chr8

124786320

+
Frame-shiftENST00000448691ENST00000334705HYDINchr16

71163543

-FAM91A1chr8

124786320

+
Frame-shiftENST00000448691ENST00000521166HYDINchr16

71163543

-FAM91A1chr8

124786320

+
In-frameENST00000288168ENST00000334705HYDINchr16

71163543

-FAM91A1chr8

124786320

+
In-frameENST00000288168ENST00000521166HYDINchr16

71163543

-FAM91A1chr8

124786320

+
In-frameENST00000538248ENST00000334705HYDINchr16

71163543

-FAM91A1chr8

124786320

+
In-frameENST00000538248ENST00000521166HYDINchr16

71163543

-FAM91A1chr8

124786320

+
In-frameENST00000541601ENST00000334705HYDINchr16

71163543

-FAM91A1chr8

124786320

+
In-frameENST00000541601ENST00000521166HYDINchr16

71163543

-FAM91A1chr8

124786320

+
intron-3CDSENST00000543639ENST00000334705HYDINchr16

71163543

-FAM91A1chr8

124786320

+
intron-3CDSENST00000543639ENST00000521166HYDINchr16

71163543

-FAM91A1chr8

124786320

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000538248HYDINchr1671163543-ENST00000521166FAM91A1chr8124786320+373013433536401201
ENST00000538248HYDINchr1671163543-ENST00000334705FAM91A1chr8124786320+653613433537871250
ENST00000541601HYDINchr1671163543-ENST00000521166FAM91A1chr8124786320+369213052736021191
ENST00000541601HYDINchr1671163543-ENST00000334705FAM91A1chr8124786320+649813052737491240
ENST00000288168HYDINchr1671163543-ENST00000521166FAM91A1chr8124786320+367912921435891191
ENST00000288168HYDINchr1671163543-ENST00000334705FAM91A1chr8124786320+648512921437361240

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000538248ENST00000521166HYDINchr1671163543-FAM91A1chr8124786320+0.0001589140.9998411
ENST00000538248ENST00000334705HYDINchr1671163543-FAM91A1chr8124786320+2.49E-050.9999751
ENST00000541601ENST00000521166HYDINchr1671163543-FAM91A1chr8124786320+0.0001582980.9998417
ENST00000541601ENST00000334705HYDINchr1671163543-FAM91A1chr8124786320+2.46E-050.9999753
ENST00000288168ENST00000521166HYDINchr1671163543-FAM91A1chr8124786320+0.0001533520.9998466
ENST00000288168ENST00000334705HYDINchr1671163543-FAM91A1chr8124786320+2.42E-050.9999758

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Fusion Genomic Features for HYDIN-FAM91A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HYDINchr1671163542-FAM91A1chr8124786319+0.1143702050.8856298
HYDINchr1671163542-FAM91A1chr8124786319+0.1143702050.8856298

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HYDIN-FAM91A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:71163543/chr8:124786320)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HYDIN

Q4G0P3

FAM91A1

Q658Y4

FUNCTION: Required for ciliary motility. {ECO:0000250}.FUNCTION: As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHYDINchr16:71163543chr8:124786320ENST00000321489-9201908_19334091018.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000321489-9202267_23654091018.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000321489-9202504_25494091018.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000393567-9861908_19334095122.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000393567-9862267_23654095122.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000393567-9862504_25494095122.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000448691-9201908_19334091018.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000448691-9202267_23654091018.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000448691-9202504_25494091018.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000538248-9191908_1933436951.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000538248-9192267_2365436951.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000538248-9192504_2549436951.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000541601-9191908_1933426941.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000541601-9192267_2365426941.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000541601-9192504_2549426941.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71163543chr8:124786320ENST00000321489-9201975_19814091018.0Compositional biasNote=Poly-Glu
HgeneHYDINchr16:71163543chr8:124786320ENST00000393567-9861975_19814095122.0Compositional biasNote=Poly-Glu
HgeneHYDINchr16:71163543chr8:124786320ENST00000448691-9201975_19814091018.0Compositional biasNote=Poly-Glu
HgeneHYDINchr16:71163543chr8:124786320ENST00000538248-9191975_1981436951.0Compositional biasNote=Poly-Glu
HgeneHYDINchr16:71163543chr8:124786320ENST00000541601-9191975_1981426941.0Compositional biasNote=Poly-Glu


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Fusion Gene Sequence for HYDIN-FAM91A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>38137_38137_1_HYDIN-FAM91A1_HYDIN_chr16_71163543_ENST00000288168_FAM91A1_chr8_124786320_ENST00000334705_length(transcript)=6485nt_BP=1292nt
AGCTCGGGCGGCGCATGGAGAGTGCGGGCGGCTTCAAGCTGGGTGAGAAAAAAAAATTACTAAAAATGACAAGTAGAAGACTTGAGGAGT
CCATGGGGGCTGTTCAGATGGGATTGGTCAATATGTTCAAAGGATTTCAAAGCAAGGTTTTGCCACCCCTGAGTCCAAAGGTGGTTACAG
AAGAAGAAGTAAACCGAATGCTTACACCCTCAGAGTTCCTGAAGGAAATGTCCCTGACCACCGAGCAGAGACTGGCAAAAACACGTTTGA
TGTGCCGACCACAGATCATCGAACTCTTAGATATGGGGGAAACAACACATCAGAAGTTTTCAGGAATTGACCTGGATCAGGCATTATTCC
AGCCCTTTCCATCAGAAATTATATTTCAGAACTACACTCCCTGTGAAGTCTATGAAGTTCCACTGATTTTGAGGAACAATGACAAAATTC
CAAGGTTGGTGAAAGTTGTGGAAGAAAGTTCGCCTTACTTTAAAGTAATCAGCCCCAAAGATATTGGCCACAAAGTGGCTCCTGGAGTGC
CTTCCATATTCCGAATCCTCTTTACTCCAGAGGAGAACAAGGATTACGCCCATACGTTGACCTGTGTTACTGAAAGAGAAAAGTTTATTG
TACCCATCAAAGCTAGAGGGGCACGAGCCATTCTCGATTTTCCTGACAAGCTGAATTTTTCCACTTGTCCTGTCAAATACAGCACCCAGA
AGATTCTGCTGGTACGAAACATTGGCAACAAAAATGCTGTATTTCACATCAAAACTTGTAGGCCTTTCTCTATAGAACCAGCTATTGGAA
CTCTTAATGTGGGAGAGTCCATGCAACTGGAAGTGGAGTTTGAGCCACAGAGTGTGGGCGATCACAGTGGAAGACTTATCGTGTGTTATG
ACACAGGTGAAAAGGTGTTTGTATCTCTCTATGGAGCTGCCATAGACATGAATATAAGGCTGGATAAGAATTCCTTGACCATCGAGAAAA
CCTACATATCTCTGGCCAATCAGCGAACTATAACCATTCACAATCGCAGTAATATCATTGCCCATTTCCTGTGGAAGGTATTTGCTACCC
AGCAAGAAGAGGACAGAGAAAAATATAGGGCCTGTGATGATCTGATCAAAGAGGAGAAGGATGAGACTGATGAGTTTTTTGAAGAGTGCA
TTACTGATCCTTTACTCCGAGAACATCTTTCTGTTCTGTCCCGAACCTTTGCGAATCAGAGGAGGCTGGTGCAGGGAGACAGCAAGCTGT
TCTTCAATAACGTTTTCACTGTGGAGCCCCTGAGTCTTGGAAATTCACAGAGAGAATATGAAAAGCAGGTTGTCCTGTACAGTATCCGCA
ATCAGTTACGATATAGAAATAACTTAGTTAAACATGTCAAGAAAGATGAACGCAGATACTATGAGGAACTGCTAAAGTACAGCCGAGATC
ATCTCATGCTGTACCCTTACCATCTATCGGATATTATGGTGAAAGGCTTGAGGATAACACCATTTTCATATTATACTGGGATTATGGAGG
ATATTATGAACAGTGAGAAAAGTTATGATTCATTGCCCAATTTTACTGCTGCTGACTGTCTAAGGCTTCTTGGCATAGGAAGAAACCAGT
ATATTGATCTTATGAATCAGTGTAGATCATCAAAAAAATTCTTCAGAAGGAAAACAGCCCGTGATCTTCTACCAATAAAGCCAGTGGAAA
TTGCCATAGAGGCGTGGTGGGTGGTGCAGGCTGGCTATATCACAGAAGATGACATCAAGATATGCACTTTGCCTGAGAAATGCGCTGTTG
ATAAGATCATCGATTCAGGCCCTCAACTCTCTGGATCACTAGATTACAATGTAGTACATAGTTTGTATAACAAAGGATTTATTTATCTGG
ATGTACCAATATCTGATGACAGTTGTATAGCAGTTCCACCTCTTGAAGGTTTTGTAATGAATCGAGTGCAAGGTGATTATTTTGAAACTC
TACTCTATAAGATATTTGTTTCAATAGATGAGCACACAAATGTTGCAGAGCTTGCAAATGTCCTTGAGATTGACTTATCCCTGGTTAAGA
ATGCTGTTTCAATGTATTGCCGATTGGGCTTTGCCCATAAGAAGGGACAAGTAATTAATTTGGATCAACTTCATTCATCATGGAAGAATG
TTCCATCCGTAAACAGATTAAAGAGTACCTTAGATCCACAGAAGATGCTCTTGTCATGGGATGGAGGGGAAAGTAGGAGTCCTGTACAAG
AAGCTTCATCGGCAACTGACACTGATACAAATAGTCAAGAAGATCCAGCTGACACAGCCAGTGTAAGCAGCCTGAGTCTGTCTACAGGAC
ACACGAAGCGCATCGCATTCCTGTTTGACTCCACTCTTACTGCCTTCTTAATGATGGGAAATCTTTCACCAAACTTGAAAAGTCATGCAG
TCACAATGTTTGAAGTAGGCAAACTCTCAGATGAGTCTCTGGACAGCTTTCTTATAGAACTAGAAAAGGTTCAGAGCACTGGTGAAGGAG
AAGCACAGAGATATTTTGATCATGCACTTACTCTGAGAAACACAATACTGTTTCTGCGTCATAACAAAGATCTAGTTGCGCAAACTGCAC
AGCCAGACCAACCCAATTATGGTTTTCCTCTGGATCTCTTACGCTGTGAAAGCCTTCTTGGTTTGGACCCTGCAACTTGCAGCAGAGTTC
TAAACAAAAATTACACGCTGCTTGTTTCCATGGCTCCCCTCACCAATGAAATCCGGCCTGTCAGCAGCTGCACCCCTCAGCATATTGGAC
CAGCTATCCCAGAAGTCAGCTCTGTCTGGTTTAAACTGTACATTTATCATGTCACTGGACAAGGACCACCATCCCTTTTATTGTCCAAAG
GTACAAGACTTCGAAAACTGCCAGATATATTTCAGAGTTATGATCGATTGCTAATAACATCTTGGGGTCATGATCCTGGAGTAGTTCCTA
CCTCAAATGTGCTCACGATGTTGAATGATGCTTTAACACATTCTGCAGTTTTAATTCAGGGGCATGGTCTGCATGGGATAGGAGAAACTG
TCCATGTCCCATTTCCATTTGATGAAACAGAACTACAAGGAGAGTTCACTCGTGTCAATATGGGTGTTCATAAAGCATTGCAGATACTAA
GGAACAGAGTGGACTTACAGCATCTCTGTGGATATGTCACCATGTTGAATGCTTCCAGCCAACTTGCAGATAGAAAACTCAGTGATGCTT
CTGATGAGAGAGGAGAACCTGATTTGGCTTCTGGCTCAGATGTAAATGGGAGTACAGAGTCATTTGAAATGGTCATTGAGGAAGCAACTA
TAGATTCAGCAACAAAGCAAACCTCTGGTGCCACAACAGAAGCAGATTGGGTTCCTCTCGAGCTGTGCTTTGGAATTCCACTGTTCAGTT
CCGAATTAAACCGGAAAGTTTGTAGGAAAATTGCTGCACATGGCCTTTGCAGAAAAGAGAGCCTTCAAAACCTCTTACATTCCAGTAGAA
AACTCTCTCTGCAAGTCCTTAACTTTGTTCACTCATTCCAGGAAGGTGCTTCAATATTGGATATTCACACAGAGCCCAGTTTTTCAAGTT
TGCTTTCACAGTCATCGTGTGCTGACATGGGTGTTCCACTTCCTGCAAAAAACTTAATATTTAAAGATGGTGTCTTATCAGAATGGAGTG
GACGGTCACCTTCCTCACTTCTTATTGCTAATCTCCATTTGCAATAATTTGGTTACACCATTTGTTGCTCACACTTTCTGCCTTTTTTCT
TTCTTAACGTTAGCTTTATAGTGTCAGCCACTAAAAAGCATCCTGCTGCTGCAGTGCAATTCTTGCTTAACTAATATTAAAAGTTGGGGA
ACATATTCATGTTTTCTGAAGTTTTGCTCATTATTGCACATCTTATTGCGACAAAGTGCTTTTTAGCAGCCAGCACTGTATTTTTTACCT
TGAGACAATCTGCATTTCTTTTATAAAACTAAGTATATACTTTATAGGCTTTATGATGACTGTTATGTTTATAAGCAGTCACTATGAAAA
TTGCAATGGTAATTTTATATGTTAGTTTATCAAACATAAATCTTGTTTAATTTTATATTTTGTTACCTATACTTTGGGGGATCAAGGGAA
GAGATGGAACTCTTCCTCTGAAAAGGCTTCTTGGTACTTAAAGTAGTAAAACTATAAAACAATAAACATCCAGTATTGAGAGATGATATG
ATAGGGCATTATGAATTCCTATGGGTGTCTGTAAATTATGTATGTCAGTTGGACATTGTAGAAGGTATGTAAATCAGCATAGTTGTGTAT
AACTTAACCTTGATTTATAAGGTCTTAAGATTATGACTATTCATTGACATCTCATGAGAAGCTTTAGAAGACTTTCTATTTTTAAACACC
ATTTATATGTGGACTTCTGTTGTCACTGACTTTGGGCTTTATATTTTCATAGAGTCTTTATGGAAAAAATAGAATTTATTTTCCACTCTT
GTAGCTATAGCTGCTGCACACTTTCACCCTGATTTATTTTTTTGTTTCTTAGCTTTGATGTTTTCAAACCAAGGATTGTGATTTTAGGTT
AGAATTACATATTAGAAGCATTAAGACTATGTCTTTGGATCAGAATGCTTTAGTGATAAACCTACTTTGAAGACATACTCTTAAGCAATC
TGGATCTTAAATTTATGTGAATACTTTTTTAGAAAATGATAAAGAAAAATGGAATTACTTCAAAGTGTTTCTTGAGTCATTGATTCTTTT
AGCATCTCAAATGTTAATTAGAATAATTGGAATCACTTTTTAGACTTTTCAAGTTACCTTCCTTGGGAAGTTTGTGCAGTGTTATAGTTT
AGTTTAGCTCCTCTTACAGGGTAATGGTTTGCTAGTTTAAAACTGTAACCAAACGAACTGGTCAGACAACATATATCTAAAACACTTAAA
ATGTTAGGAAGTTTGGGAATGTTATAACCTAAACGTTTTTGCTGGTAACTTTTTGTTATTTATAGATATTTGTGTATTTAACATACATAC
TTCAGGAAATATATGCCTTTCCTAAAACTTAACCATGCATTCAATACCATGGCCTATCTATAGAATTGAATATTTTGGACCATGTTATCT
GTGGCACAGTCAGTGCTGTGTTTGAGGTAAATGCAGTAACGGTTAGTTTTCTACTTTGTCTTATAGAAGGTAGAAACCATGTGTATGTTA
TGTTTGTCTATAAAAGAAAAAATACTAATATTAAATAATTTCTTACGACTCTGAGTCACTCACTTATTTTTCCAATAATTGATATTGTAC
ATTCCTAGTGCCATTAGGTATGTATGTATGTAACTTTTACAGTTTTTCAGCTGAAAGTTGTAAGTATTTTTTTTTTTTGATCGGGGCTCT
TTAATCTCATTTTAATTTCCTTTGTTTGAACTGTAGTTATTTTATTTATTCCTATATTAACCATCTAAACCAACTGTAATGACATGTACA
CTAATACAGAATTGAACATTTGTAGTTGTTGGCAGTGAACCCAGTTGTTGGTGAATTTAAAGCTTAAAATATGGGAATGATTTGCTGCTA
TATTTCCTTTGAGAGAGAAAGGAGGAAGAAATAGAACCTAATAGTGATCATGAATTTTAGGGAAAGTACCGAAGAACCATGGGGTCCCCT
CTGGTTTCTTGTGTTGAATGAGGCAAGGGTAATCATCTGATTCCGAGCTGAAGACCTCTGGTCCTCTTAAGGAGGGAGAGTGCATTTTTA
GAGCTTTTAGCAAAATGTGAAAAGCTGATGTTTGCGCCTTGCTTTGTGAATTTGGCTTTGTTTTACTTATACATTAACTCATGTAATCTC
TTAAATCTTACAAGCATTGATCCATTTCAACAAAAAGGTAAATTTAAAATGCAGACTTTGTTATTTGCCAAAGAAGATTCATGAAAAATT
TACGTCCAATTATTTTGCAAATAGTTAATTTCATTTGGCTTTTTACCATGTTCCTTCCTTTCTTTTTCCCGCTTCCTTAATGTAATTTAA
ACCCTGGCAAACATTCTTTAGAAACCAAGAGGAAAGAAAGAACAAATATCAAAAAAGACATAGAATTTAATATTGATACAATTTCACCTC
TAAAATGGATTTGAAGAAATGCAACTTTATATCAAAAAATGTCATCTGATTTCCTTTGTTTCTTTTTTAAATTATGTAATCAGATGATTT
TATGTTTTTTTTTCAGGGGAGCGGAATATTGGTTTCTTTTACTTGTTGTTTTCAGTTTTCTCTGCCATTCATGTTTCTTTTTTGTGTTCA
GTGTTTCAAATACAATTTGTATTTAAGGATTTTAAAATACCAAACTGTAACTGAGTACAGTGGATCGTTTTCTGTTAGGATGTTAATATT
ATACAATGAAATCTATAAAGTGTTGTCAATTTGATTATTGACACATATAACATGTTTACAAATAAACTGTGGTATTGATCAAGTTACTAT

>38137_38137_1_HYDIN-FAM91A1_HYDIN_chr16_71163543_ENST00000288168_FAM91A1_chr8_124786320_ENST00000334705_length(amino acids)=1240AA_BP=426
MESAGGFKLGEKKKLLKMTSRRLEESMGAVQMGLVNMFKGFQSKVLPPLSPKVVTEEEVNRMLTPSEFLKEMSLTTEQRLAKTRLMCRPQ
IIELLDMGETTHQKFSGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLILRNNDKIPRLVKVVEESSPYFKVISPKDIGHKVAPGVPSIFR
ILFTPEENKDYAHTLTCVTEREKFIVPIKARGARAILDFPDKLNFSTCPVKYSTQKILLVRNIGNKNAVFHIKTCRPFSIEPAIGTLNVG
ESMQLEVEFEPQSVGDHSGRLIVCYDTGEKVFVSLYGAAIDMNIRLDKNSLTIEKTYISLANQRTITIHNRSNIIAHFLWKVFATQQEED
REKYRACDDLIKEEKDETDEFFEECITDPLLREHLSVLSRTFANQRRLVQGDSKLFFNNVFTVEPLSLGNSQREYEKQVVLYSIRNQLRY
RNNLVKHVKKDERRYYEELLKYSRDHLMLYPYHLSDIMVKGLRITPFSYYTGIMEDIMNSEKSYDSLPNFTAADCLRLLGIGRNQYIDLM
NQCRSSKKFFRRKTARDLLPIKPVEIAIEAWWVVQAGYITEDDIKICTLPEKCAVDKIIDSGPQLSGSLDYNVVHSLYNKGFIYLDVPIS
DDSCIAVPPLEGFVMNRVQGDYFETLLYKIFVSIDEHTNVAELANVLEIDLSLVKNAVSMYCRLGFAHKKGQVINLDQLHSSWKNVPSVN
RLKSTLDPQKMLLSWDGGESRSPVQEASSATDTDTNSQEDPADTASVSSLSLSTGHTKRIAFLFDSTLTAFLMMGNLSPNLKSHAVTMFE
VGKLSDESLDSFLIELEKVQSTGEGEAQRYFDHALTLRNTILFLRHNKDLVAQTAQPDQPNYGFPLDLLRCESLLGLDPATCSRVLNKNY
TLLVSMAPLTNEIRPVSSCTPQHIGPAIPEVSSVWFKLYIYHVTGQGPPSLLLSKGTRLRKLPDIFQSYDRLLITSWGHDPGVVPTSNVL
TMLNDALTHSAVLIQGHGLHGIGETVHVPFPFDETELQGEFTRVNMGVHKALQILRNRVDLQHLCGYVTMLNASSQLADRKLSDASDERG
EPDLASGSDVNGSTESFEMVIEEATIDSATKQTSGATTEADWVPLELCFGIPLFSSELNRKVCRKIAAHGLCRKESLQNLLHSSRKLSLQ

--------------------------------------------------------------
>38137_38137_2_HYDIN-FAM91A1_HYDIN_chr16_71163543_ENST00000288168_FAM91A1_chr8_124786320_ENST00000521166_length(transcript)=3679nt_BP=1292nt
AGCTCGGGCGGCGCATGGAGAGTGCGGGCGGCTTCAAGCTGGGTGAGAAAAAAAAATTACTAAAAATGACAAGTAGAAGACTTGAGGAGT
CCATGGGGGCTGTTCAGATGGGATTGGTCAATATGTTCAAAGGATTTCAAAGCAAGGTTTTGCCACCCCTGAGTCCAAAGGTGGTTACAG
AAGAAGAAGTAAACCGAATGCTTACACCCTCAGAGTTCCTGAAGGAAATGTCCCTGACCACCGAGCAGAGACTGGCAAAAACACGTTTGA
TGTGCCGACCACAGATCATCGAACTCTTAGATATGGGGGAAACAACACATCAGAAGTTTTCAGGAATTGACCTGGATCAGGCATTATTCC
AGCCCTTTCCATCAGAAATTATATTTCAGAACTACACTCCCTGTGAAGTCTATGAAGTTCCACTGATTTTGAGGAACAATGACAAAATTC
CAAGGTTGGTGAAAGTTGTGGAAGAAAGTTCGCCTTACTTTAAAGTAATCAGCCCCAAAGATATTGGCCACAAAGTGGCTCCTGGAGTGC
CTTCCATATTCCGAATCCTCTTTACTCCAGAGGAGAACAAGGATTACGCCCATACGTTGACCTGTGTTACTGAAAGAGAAAAGTTTATTG
TACCCATCAAAGCTAGAGGGGCACGAGCCATTCTCGATTTTCCTGACAAGCTGAATTTTTCCACTTGTCCTGTCAAATACAGCACCCAGA
AGATTCTGCTGGTACGAAACATTGGCAACAAAAATGCTGTATTTCACATCAAAACTTGTAGGCCTTTCTCTATAGAACCAGCTATTGGAA
CTCTTAATGTGGGAGAGTCCATGCAACTGGAAGTGGAGTTTGAGCCACAGAGTGTGGGCGATCACAGTGGAAGACTTATCGTGTGTTATG
ACACAGGTGAAAAGGTGTTTGTATCTCTCTATGGAGCTGCCATAGACATGAATATAAGGCTGGATAAGAATTCCTTGACCATCGAGAAAA
CCTACATATCTCTGGCCAATCAGCGAACTATAACCATTCACAATCGCAGTAATATCATTGCCCATTTCCTGTGGAAGGTATTTGCTACCC
AGCAAGAAGAGGACAGAGAAAAATATAGGGCCTGTGATGATCTGATCAAAGAGGAGAAGGATGAGACTGATGAGTTTTTTGAAGAGTGCA
TTACTGATCCTTTACTCCGAGAACATCTTTCTGTTCTGTCCCGAACCTTTGCGAATCAGAGGAGGCTGGTGCAGGGAGACAGCAAGCTGT
TCTTCAATAACGTTTTCACTGTGGAGCCCCTGAGTCTTGGAAATTCACAGAGAGAATATGAAAAGCAGGTTGTCCTGTACAGTATCCGCA
ATCAGTTACGATATAGAAATAACTTAGTTAAACATGTCAAGAAAGATGAACGCAGATACTATGAGGAACTGCTAAAGTACAGCCGAGATC
ATCTCATGCTGTACCCTTACCATCTATCGGATATTATGGTGAAAGGCTTGAGGATAACACCATTTTCATATTATACTGGGATTATGGAGG
ATATTATGAACAGTGAGAAAAGTTATGATTCATTGCCCAATTTTACTGCTGCTGACTGTCTAAGGCTTCTTGGCATAGGAAGAAACCAGT
ATATTGATCTTATGAATCAGTGTAGATCATCAAAAAAATTCTTCAGAAGGAAAACAGCCCGTGATCTTCTACCAATAAAGCCAGTGGAAA
TTGCCATAGAGGCGTGGTGGGTGGTGCAGGCTGGCTATATCACAGAAGATGACATCAAGATATGCACTTTGCCTGAGAAATGCGCTGTTG
ATAAGATCATCGATTCAGGCCCTCAACTCTCTGGATCACTAGATTACAATGTAGTACATAGTTTGTATAACAAAGGATTTATTTATCTGG
ATGTACCAATATCTGATGACAGTTGTATAGCAGTTCCACCTCTTGAAGGTTTTGTAATGAATCGAGTGCAAGGTGATTATTTTGAAACTC
TACTCTATAAGATATTTGTTTCAATAGATGAGCACACAAATGTTGCAGAGCTTGCAAATGTCCTTGAGATTGACTTATCCCTGGTTAAGA
ATGCTGTTTCAATGTATTGCCGATTGGGCTTTGCCCATAAGAAGGGACAAGTAATTAATTTGGATCAACTTCATTCATCATGGAAGAATG
TTCCATCCGTAAACAGATTAAAGAGTACCTTAGATCCACAGAAGATGCTCTTGTCATGGGATGGAGGGGAAAGTAGGAGTCCTGTACAAG
AAGCTTCATCGGCAACTGACACTGATACAAATAGTCAAGAAGATCCAGCTGACACAGCCAGTGTAAGCAGCCTGAGTCTGTCTACAGGAC
ACACGAAGCGCATCGCATTCCTGTTTGACTCCACTCTTACTGCCTTCTTAATGATGGGAAATCTTTCACCAAACTTGAAAAGTCATGCAG
TCACAATGTTTGAAGTAGGCAAACTCTCAGATGAGTCTCTGGACAGCTTTCTTATAGAACTAGAAAAGGTTCAGAGCACTGGTGAAGGAG
AAGCACAGAGATATTTTGATCATGCACTTACTCTGAGAAACACAATACTGTTTCTGCGTCATAACAAAGATCTAGTTGCGCAAACTGCAC
AGCCAGACCAACCCAATTATGGTTTTCCTCTGGATCTCTTACGCTGTGAAAGCCTTCTTGGTTTGGACCCTGCAACTTGCAGCAGAGTTC
TAAACAAAAATTACACGCTGCTTGTTTCCATGGCTCCCCTCACCAATGAAATCCGGCCTGTCAGCAGCTGCACCCCTCAGCATATTGGAC
CAGCTATCCCAGAAGTCAGCTCTGTCTGGTTTAAACTGTACATTTATCATGTCACTGGACAAGGACCACCATCCCTTTTATTGTCCAAAG
GTACAAGACTTCGAAAACTGCCAGATATATTTCAGAGTTATGATCGATTGCTAATAACATCTTGGGGTCATGATCCTGGAGTAGTTCCTA
CCTCAAATGTGCTCACGATGTTGAATGATGCTTTAACACATTCTGCAGTTTTAATTCAGGGGCATGGTCTGCATGGGATAGGAGAAACTG
TCCATGTCCCATTTCCATTTGATGAAACAGAACTACAAGGAGAGTTCACTCGTGTCAATATGGGTGTTCATAAAGCATTGCAGATACTAA
GGAACAGAGTGGACTTACAGCATCTCTGTGGATATGTCACCATGTTGAATGCTTCCAGCCAACTTGCAGATAGAAAACTCAGTGATGCTT
CTGATGAGAGAGGAGAACCTGATTTGGCTTCTGGCTCAGATGTAAATGGGAGTACAGAGTCATTTGAAATGGTCATTGAGGAAGCAACTA
TAGATTCAGCAACAAAGCAAACCTCTGGTGCCACAACAGAAGCAGATTGGGTTCCTCTCGAGCTGTGCTTTGGAATTCCACTGTTCAGTT
CCGAATTAAACCGGAAAGTTTGTAGGAAAATTGCTGCACATGGCCTTTGCAGAAAAGAGAGCCTTCAAAACCTCTTACATTCCAGTAGAA
AACTCTCTCTGCAAGTCCTTAACTTTGTTCACTCATTCCAGGTAACAAAAACCAAAAAGTCCAAATGGTACTTGTACTGAGCTTTAAGTA

>38137_38137_2_HYDIN-FAM91A1_HYDIN_chr16_71163543_ENST00000288168_FAM91A1_chr8_124786320_ENST00000521166_length(amino acids)=1191AA_BP=426
MESAGGFKLGEKKKLLKMTSRRLEESMGAVQMGLVNMFKGFQSKVLPPLSPKVVTEEEVNRMLTPSEFLKEMSLTTEQRLAKTRLMCRPQ
IIELLDMGETTHQKFSGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLILRNNDKIPRLVKVVEESSPYFKVISPKDIGHKVAPGVPSIFR
ILFTPEENKDYAHTLTCVTEREKFIVPIKARGARAILDFPDKLNFSTCPVKYSTQKILLVRNIGNKNAVFHIKTCRPFSIEPAIGTLNVG
ESMQLEVEFEPQSVGDHSGRLIVCYDTGEKVFVSLYGAAIDMNIRLDKNSLTIEKTYISLANQRTITIHNRSNIIAHFLWKVFATQQEED
REKYRACDDLIKEEKDETDEFFEECITDPLLREHLSVLSRTFANQRRLVQGDSKLFFNNVFTVEPLSLGNSQREYEKQVVLYSIRNQLRY
RNNLVKHVKKDERRYYEELLKYSRDHLMLYPYHLSDIMVKGLRITPFSYYTGIMEDIMNSEKSYDSLPNFTAADCLRLLGIGRNQYIDLM
NQCRSSKKFFRRKTARDLLPIKPVEIAIEAWWVVQAGYITEDDIKICTLPEKCAVDKIIDSGPQLSGSLDYNVVHSLYNKGFIYLDVPIS
DDSCIAVPPLEGFVMNRVQGDYFETLLYKIFVSIDEHTNVAELANVLEIDLSLVKNAVSMYCRLGFAHKKGQVINLDQLHSSWKNVPSVN
RLKSTLDPQKMLLSWDGGESRSPVQEASSATDTDTNSQEDPADTASVSSLSLSTGHTKRIAFLFDSTLTAFLMMGNLSPNLKSHAVTMFE
VGKLSDESLDSFLIELEKVQSTGEGEAQRYFDHALTLRNTILFLRHNKDLVAQTAQPDQPNYGFPLDLLRCESLLGLDPATCSRVLNKNY
TLLVSMAPLTNEIRPVSSCTPQHIGPAIPEVSSVWFKLYIYHVTGQGPPSLLLSKGTRLRKLPDIFQSYDRLLITSWGHDPGVVPTSNVL
TMLNDALTHSAVLIQGHGLHGIGETVHVPFPFDETELQGEFTRVNMGVHKALQILRNRVDLQHLCGYVTMLNASSQLADRKLSDASDERG
EPDLASGSDVNGSTESFEMVIEEATIDSATKQTSGATTEADWVPLELCFGIPLFSSELNRKVCRKIAAHGLCRKESLQNLLHSSRKLSLQ

--------------------------------------------------------------
>38137_38137_3_HYDIN-FAM91A1_HYDIN_chr16_71163543_ENST00000538248_FAM91A1_chr8_124786320_ENST00000334705_length(transcript)=6536nt_BP=1343nt
ACCGTGGCAACGGACGGCAACAGCTCGGGCGGCGCATGGAGAGTGCGGGCGGCTTCAAGCTGGGTATGGAGCCCCTCAGCGGCGGCGGGG
TCTGTGAGAAAAAAAAATTACTAAAAATGACAAGTAGAAGACTTGAGGAGTCCATGGGGGCTGTTCAGATGGGATTGGTCAATATGTTCA
AAGGATTTCAAAGCAAGGTTTTGCCACCCCTGAGTCCAAAGGTGGTTACAGAAGAAGAAGTAAACCGAATGCTTACACCCTCAGAGTTCC
TGAAGGAAATGTCCCTGACCACCGAGCAGAGACTGGCAAAAACACGTTTGATGTGCCGACCACAGATCATCGAACTCTTAGATATGGGGG
AAACAACACATCAGAAGTTTTCAGGAATTGACCTGGATCAGGCATTATTCCAGCCCTTTCCATCAGAAATTATATTTCAGAACTACACTC
CCTGTGAAGTCTATGAAGTTCCACTGATTTTGAGGAACAATGACAAAATTCCAAGGTTGGTGAAAGTTGTGGAAGAAAGTTCGCCTTACT
TTAAAGTAATCAGCCCCAAAGATATTGGCCACAAAGTGGCTCCTGGAGTGCCTTCCATATTCCGAATCCTCTTTACTCCAGAGGAGAACA
AGGATTACGCCCATACGTTGACCTGTGTTACTGAAAGAGAAAAGTTTATTGTACCCATCAAAGCTAGAGGGGCACGAGCCATTCTCGATT
TTCCTGACAAGCTGAATTTTTCCACTTGTCCTGTCAAATACAGCACCCAGAAGATTCTGCTGGTACGAAACATTGGCAACAAAAATGCTG
TATTTCACATCAAAACTTGTAGGCCTTTCTCTATAGAACCAGCTATTGGAACTCTTAATGTGGGAGAGTCCATGCAACTGGAAGTGGAGT
TTGAGCCACAGAGTGTGGGCGATCACAGTGGAAGACTTATCGTGTGTTATGACACAGGTGAAAAGGTGTTTGTATCTCTCTATGGAGCTG
CCATAGACATGAATATAAGGCTGGATAAGAATTCCTTGACCATCGAGAAAACCTACATATCTCTGGCCAATCAGCGAACTATAACCATTC
ACAATCGCAGTAATATCATTGCCCATTTCCTGTGGAAGGTATTTGCTACCCAGCAAGAAGAGGACAGAGAAAAATATAGGGCCTGTGATG
ATCTGATCAAAGAGGAGAAGGATGAGACTGATGAGTTTTTTGAAGAGTGCATTACTGATCCTTTACTCCGAGAACATCTTTCTGTTCTGT
CCCGAACCTTTGCGAATCAGAGGAGGCTGGTGCAGGGAGACAGCAAGCTGTTCTTCAATAACGTTTTCACTGTGGAGCCCCTGAGTCTTG
GAAATTCACAGAGAGAATATGAAAAGCAGGTTGTCCTGTACAGTATCCGCAATCAGTTACGATATAGAAATAACTTAGTTAAACATGTCA
AGAAAGATGAACGCAGATACTATGAGGAACTGCTAAAGTACAGCCGAGATCATCTCATGCTGTACCCTTACCATCTATCGGATATTATGG
TGAAAGGCTTGAGGATAACACCATTTTCATATTATACTGGGATTATGGAGGATATTATGAACAGTGAGAAAAGTTATGATTCATTGCCCA
ATTTTACTGCTGCTGACTGTCTAAGGCTTCTTGGCATAGGAAGAAACCAGTATATTGATCTTATGAATCAGTGTAGATCATCAAAAAAAT
TCTTCAGAAGGAAAACAGCCCGTGATCTTCTACCAATAAAGCCAGTGGAAATTGCCATAGAGGCGTGGTGGGTGGTGCAGGCTGGCTATA
TCACAGAAGATGACATCAAGATATGCACTTTGCCTGAGAAATGCGCTGTTGATAAGATCATCGATTCAGGCCCTCAACTCTCTGGATCAC
TAGATTACAATGTAGTACATAGTTTGTATAACAAAGGATTTATTTATCTGGATGTACCAATATCTGATGACAGTTGTATAGCAGTTCCAC
CTCTTGAAGGTTTTGTAATGAATCGAGTGCAAGGTGATTATTTTGAAACTCTACTCTATAAGATATTTGTTTCAATAGATGAGCACACAA
ATGTTGCAGAGCTTGCAAATGTCCTTGAGATTGACTTATCCCTGGTTAAGAATGCTGTTTCAATGTATTGCCGATTGGGCTTTGCCCATA
AGAAGGGACAAGTAATTAATTTGGATCAACTTCATTCATCATGGAAGAATGTTCCATCCGTAAACAGATTAAAGAGTACCTTAGATCCAC
AGAAGATGCTCTTGTCATGGGATGGAGGGGAAAGTAGGAGTCCTGTACAAGAAGCTTCATCGGCAACTGACACTGATACAAATAGTCAAG
AAGATCCAGCTGACACAGCCAGTGTAAGCAGCCTGAGTCTGTCTACAGGACACACGAAGCGCATCGCATTCCTGTTTGACTCCACTCTTA
CTGCCTTCTTAATGATGGGAAATCTTTCACCAAACTTGAAAAGTCATGCAGTCACAATGTTTGAAGTAGGCAAACTCTCAGATGAGTCTC
TGGACAGCTTTCTTATAGAACTAGAAAAGGTTCAGAGCACTGGTGAAGGAGAAGCACAGAGATATTTTGATCATGCACTTACTCTGAGAA
ACACAATACTGTTTCTGCGTCATAACAAAGATCTAGTTGCGCAAACTGCACAGCCAGACCAACCCAATTATGGTTTTCCTCTGGATCTCT
TACGCTGTGAAAGCCTTCTTGGTTTGGACCCTGCAACTTGCAGCAGAGTTCTAAACAAAAATTACACGCTGCTTGTTTCCATGGCTCCCC
TCACCAATGAAATCCGGCCTGTCAGCAGCTGCACCCCTCAGCATATTGGACCAGCTATCCCAGAAGTCAGCTCTGTCTGGTTTAAACTGT
ACATTTATCATGTCACTGGACAAGGACCACCATCCCTTTTATTGTCCAAAGGTACAAGACTTCGAAAACTGCCAGATATATTTCAGAGTT
ATGATCGATTGCTAATAACATCTTGGGGTCATGATCCTGGAGTAGTTCCTACCTCAAATGTGCTCACGATGTTGAATGATGCTTTAACAC
ATTCTGCAGTTTTAATTCAGGGGCATGGTCTGCATGGGATAGGAGAAACTGTCCATGTCCCATTTCCATTTGATGAAACAGAACTACAAG
GAGAGTTCACTCGTGTCAATATGGGTGTTCATAAAGCATTGCAGATACTAAGGAACAGAGTGGACTTACAGCATCTCTGTGGATATGTCA
CCATGTTGAATGCTTCCAGCCAACTTGCAGATAGAAAACTCAGTGATGCTTCTGATGAGAGAGGAGAACCTGATTTGGCTTCTGGCTCAG
ATGTAAATGGGAGTACAGAGTCATTTGAAATGGTCATTGAGGAAGCAACTATAGATTCAGCAACAAAGCAAACCTCTGGTGCCACAACAG
AAGCAGATTGGGTTCCTCTCGAGCTGTGCTTTGGAATTCCACTGTTCAGTTCCGAATTAAACCGGAAAGTTTGTAGGAAAATTGCTGCAC
ATGGCCTTTGCAGAAAAGAGAGCCTTCAAAACCTCTTACATTCCAGTAGAAAACTCTCTCTGCAAGTCCTTAACTTTGTTCACTCATTCC
AGGAAGGTGCTTCAATATTGGATATTCACACAGAGCCCAGTTTTTCAAGTTTGCTTTCACAGTCATCGTGTGCTGACATGGGTGTTCCAC
TTCCTGCAAAAAACTTAATATTTAAAGATGGTGTCTTATCAGAATGGAGTGGACGGTCACCTTCCTCACTTCTTATTGCTAATCTCCATT
TGCAATAATTTGGTTACACCATTTGTTGCTCACACTTTCTGCCTTTTTTCTTTCTTAACGTTAGCTTTATAGTGTCAGCCACTAAAAAGC
ATCCTGCTGCTGCAGTGCAATTCTTGCTTAACTAATATTAAAAGTTGGGGAACATATTCATGTTTTCTGAAGTTTTGCTCATTATTGCAC
ATCTTATTGCGACAAAGTGCTTTTTAGCAGCCAGCACTGTATTTTTTACCTTGAGACAATCTGCATTTCTTTTATAAAACTAAGTATATA
CTTTATAGGCTTTATGATGACTGTTATGTTTATAAGCAGTCACTATGAAAATTGCAATGGTAATTTTATATGTTAGTTTATCAAACATAA
ATCTTGTTTAATTTTATATTTTGTTACCTATACTTTGGGGGATCAAGGGAAGAGATGGAACTCTTCCTCTGAAAAGGCTTCTTGGTACTT
AAAGTAGTAAAACTATAAAACAATAAACATCCAGTATTGAGAGATGATATGATAGGGCATTATGAATTCCTATGGGTGTCTGTAAATTAT
GTATGTCAGTTGGACATTGTAGAAGGTATGTAAATCAGCATAGTTGTGTATAACTTAACCTTGATTTATAAGGTCTTAAGATTATGACTA
TTCATTGACATCTCATGAGAAGCTTTAGAAGACTTTCTATTTTTAAACACCATTTATATGTGGACTTCTGTTGTCACTGACTTTGGGCTT
TATATTTTCATAGAGTCTTTATGGAAAAAATAGAATTTATTTTCCACTCTTGTAGCTATAGCTGCTGCACACTTTCACCCTGATTTATTT
TTTTGTTTCTTAGCTTTGATGTTTTCAAACCAAGGATTGTGATTTTAGGTTAGAATTACATATTAGAAGCATTAAGACTATGTCTTTGGA
TCAGAATGCTTTAGTGATAAACCTACTTTGAAGACATACTCTTAAGCAATCTGGATCTTAAATTTATGTGAATACTTTTTTAGAAAATGA
TAAAGAAAAATGGAATTACTTCAAAGTGTTTCTTGAGTCATTGATTCTTTTAGCATCTCAAATGTTAATTAGAATAATTGGAATCACTTT
TTAGACTTTTCAAGTTACCTTCCTTGGGAAGTTTGTGCAGTGTTATAGTTTAGTTTAGCTCCTCTTACAGGGTAATGGTTTGCTAGTTTA
AAACTGTAACCAAACGAACTGGTCAGACAACATATATCTAAAACACTTAAAATGTTAGGAAGTTTGGGAATGTTATAACCTAAACGTTTT
TGCTGGTAACTTTTTGTTATTTATAGATATTTGTGTATTTAACATACATACTTCAGGAAATATATGCCTTTCCTAAAACTTAACCATGCA
TTCAATACCATGGCCTATCTATAGAATTGAATATTTTGGACCATGTTATCTGTGGCACAGTCAGTGCTGTGTTTGAGGTAAATGCAGTAA
CGGTTAGTTTTCTACTTTGTCTTATAGAAGGTAGAAACCATGTGTATGTTATGTTTGTCTATAAAAGAAAAAATACTAATATTAAATAAT
TTCTTACGACTCTGAGTCACTCACTTATTTTTCCAATAATTGATATTGTACATTCCTAGTGCCATTAGGTATGTATGTATGTAACTTTTA
CAGTTTTTCAGCTGAAAGTTGTAAGTATTTTTTTTTTTTGATCGGGGCTCTTTAATCTCATTTTAATTTCCTTTGTTTGAACTGTAGTTA
TTTTATTTATTCCTATATTAACCATCTAAACCAACTGTAATGACATGTACACTAATACAGAATTGAACATTTGTAGTTGTTGGCAGTGAA
CCCAGTTGTTGGTGAATTTAAAGCTTAAAATATGGGAATGATTTGCTGCTATATTTCCTTTGAGAGAGAAAGGAGGAAGAAATAGAACCT
AATAGTGATCATGAATTTTAGGGAAAGTACCGAAGAACCATGGGGTCCCCTCTGGTTTCTTGTGTTGAATGAGGCAAGGGTAATCATCTG
ATTCCGAGCTGAAGACCTCTGGTCCTCTTAAGGAGGGAGAGTGCATTTTTAGAGCTTTTAGCAAAATGTGAAAAGCTGATGTTTGCGCCT
TGCTTTGTGAATTTGGCTTTGTTTTACTTATACATTAACTCATGTAATCTCTTAAATCTTACAAGCATTGATCCATTTCAACAAAAAGGT
AAATTTAAAATGCAGACTTTGTTATTTGCCAAAGAAGATTCATGAAAAATTTACGTCCAATTATTTTGCAAATAGTTAATTTCATTTGGC
TTTTTACCATGTTCCTTCCTTTCTTTTTCCCGCTTCCTTAATGTAATTTAAACCCTGGCAAACATTCTTTAGAAACCAAGAGGAAAGAAA
GAACAAATATCAAAAAAGACATAGAATTTAATATTGATACAATTTCACCTCTAAAATGGATTTGAAGAAATGCAACTTTATATCAAAAAA
TGTCATCTGATTTCCTTTGTTTCTTTTTTAAATTATGTAATCAGATGATTTTATGTTTTTTTTTCAGGGGAGCGGAATATTGGTTTCTTT
TACTTGTTGTTTTCAGTTTTCTCTGCCATTCATGTTTCTTTTTTGTGTTCAGTGTTTCAAATACAATTTGTATTTAAGGATTTTAAAATA
CCAAACTGTAACTGAGTACAGTGGATCGTTTTCTGTTAGGATGTTAATATTATACAATGAAATCTATAAAGTGTTGTCAATTTGATTATT

>38137_38137_3_HYDIN-FAM91A1_HYDIN_chr16_71163543_ENST00000538248_FAM91A1_chr8_124786320_ENST00000334705_length(amino acids)=1250AA_BP=436
MESAGGFKLGMEPLSGGGVCEKKKLLKMTSRRLEESMGAVQMGLVNMFKGFQSKVLPPLSPKVVTEEEVNRMLTPSEFLKEMSLTTEQRL
AKTRLMCRPQIIELLDMGETTHQKFSGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLILRNNDKIPRLVKVVEESSPYFKVISPKDIGHK
VAPGVPSIFRILFTPEENKDYAHTLTCVTEREKFIVPIKARGARAILDFPDKLNFSTCPVKYSTQKILLVRNIGNKNAVFHIKTCRPFSI
EPAIGTLNVGESMQLEVEFEPQSVGDHSGRLIVCYDTGEKVFVSLYGAAIDMNIRLDKNSLTIEKTYISLANQRTITIHNRSNIIAHFLW
KVFATQQEEDREKYRACDDLIKEEKDETDEFFEECITDPLLREHLSVLSRTFANQRRLVQGDSKLFFNNVFTVEPLSLGNSQREYEKQVV
LYSIRNQLRYRNNLVKHVKKDERRYYEELLKYSRDHLMLYPYHLSDIMVKGLRITPFSYYTGIMEDIMNSEKSYDSLPNFTAADCLRLLG
IGRNQYIDLMNQCRSSKKFFRRKTARDLLPIKPVEIAIEAWWVVQAGYITEDDIKICTLPEKCAVDKIIDSGPQLSGSLDYNVVHSLYNK
GFIYLDVPISDDSCIAVPPLEGFVMNRVQGDYFETLLYKIFVSIDEHTNVAELANVLEIDLSLVKNAVSMYCRLGFAHKKGQVINLDQLH
SSWKNVPSVNRLKSTLDPQKMLLSWDGGESRSPVQEASSATDTDTNSQEDPADTASVSSLSLSTGHTKRIAFLFDSTLTAFLMMGNLSPN
LKSHAVTMFEVGKLSDESLDSFLIELEKVQSTGEGEAQRYFDHALTLRNTILFLRHNKDLVAQTAQPDQPNYGFPLDLLRCESLLGLDPA
TCSRVLNKNYTLLVSMAPLTNEIRPVSSCTPQHIGPAIPEVSSVWFKLYIYHVTGQGPPSLLLSKGTRLRKLPDIFQSYDRLLITSWGHD
PGVVPTSNVLTMLNDALTHSAVLIQGHGLHGIGETVHVPFPFDETELQGEFTRVNMGVHKALQILRNRVDLQHLCGYVTMLNASSQLADR
KLSDASDERGEPDLASGSDVNGSTESFEMVIEEATIDSATKQTSGATTEADWVPLELCFGIPLFSSELNRKVCRKIAAHGLCRKESLQNL

--------------------------------------------------------------
>38137_38137_4_HYDIN-FAM91A1_HYDIN_chr16_71163543_ENST00000538248_FAM91A1_chr8_124786320_ENST00000521166_length(transcript)=3730nt_BP=1343nt
ACCGTGGCAACGGACGGCAACAGCTCGGGCGGCGCATGGAGAGTGCGGGCGGCTTCAAGCTGGGTATGGAGCCCCTCAGCGGCGGCGGGG
TCTGTGAGAAAAAAAAATTACTAAAAATGACAAGTAGAAGACTTGAGGAGTCCATGGGGGCTGTTCAGATGGGATTGGTCAATATGTTCA
AAGGATTTCAAAGCAAGGTTTTGCCACCCCTGAGTCCAAAGGTGGTTACAGAAGAAGAAGTAAACCGAATGCTTACACCCTCAGAGTTCC
TGAAGGAAATGTCCCTGACCACCGAGCAGAGACTGGCAAAAACACGTTTGATGTGCCGACCACAGATCATCGAACTCTTAGATATGGGGG
AAACAACACATCAGAAGTTTTCAGGAATTGACCTGGATCAGGCATTATTCCAGCCCTTTCCATCAGAAATTATATTTCAGAACTACACTC
CCTGTGAAGTCTATGAAGTTCCACTGATTTTGAGGAACAATGACAAAATTCCAAGGTTGGTGAAAGTTGTGGAAGAAAGTTCGCCTTACT
TTAAAGTAATCAGCCCCAAAGATATTGGCCACAAAGTGGCTCCTGGAGTGCCTTCCATATTCCGAATCCTCTTTACTCCAGAGGAGAACA
AGGATTACGCCCATACGTTGACCTGTGTTACTGAAAGAGAAAAGTTTATTGTACCCATCAAAGCTAGAGGGGCACGAGCCATTCTCGATT
TTCCTGACAAGCTGAATTTTTCCACTTGTCCTGTCAAATACAGCACCCAGAAGATTCTGCTGGTACGAAACATTGGCAACAAAAATGCTG
TATTTCACATCAAAACTTGTAGGCCTTTCTCTATAGAACCAGCTATTGGAACTCTTAATGTGGGAGAGTCCATGCAACTGGAAGTGGAGT
TTGAGCCACAGAGTGTGGGCGATCACAGTGGAAGACTTATCGTGTGTTATGACACAGGTGAAAAGGTGTTTGTATCTCTCTATGGAGCTG
CCATAGACATGAATATAAGGCTGGATAAGAATTCCTTGACCATCGAGAAAACCTACATATCTCTGGCCAATCAGCGAACTATAACCATTC
ACAATCGCAGTAATATCATTGCCCATTTCCTGTGGAAGGTATTTGCTACCCAGCAAGAAGAGGACAGAGAAAAATATAGGGCCTGTGATG
ATCTGATCAAAGAGGAGAAGGATGAGACTGATGAGTTTTTTGAAGAGTGCATTACTGATCCTTTACTCCGAGAACATCTTTCTGTTCTGT
CCCGAACCTTTGCGAATCAGAGGAGGCTGGTGCAGGGAGACAGCAAGCTGTTCTTCAATAACGTTTTCACTGTGGAGCCCCTGAGTCTTG
GAAATTCACAGAGAGAATATGAAAAGCAGGTTGTCCTGTACAGTATCCGCAATCAGTTACGATATAGAAATAACTTAGTTAAACATGTCA
AGAAAGATGAACGCAGATACTATGAGGAACTGCTAAAGTACAGCCGAGATCATCTCATGCTGTACCCTTACCATCTATCGGATATTATGG
TGAAAGGCTTGAGGATAACACCATTTTCATATTATACTGGGATTATGGAGGATATTATGAACAGTGAGAAAAGTTATGATTCATTGCCCA
ATTTTACTGCTGCTGACTGTCTAAGGCTTCTTGGCATAGGAAGAAACCAGTATATTGATCTTATGAATCAGTGTAGATCATCAAAAAAAT
TCTTCAGAAGGAAAACAGCCCGTGATCTTCTACCAATAAAGCCAGTGGAAATTGCCATAGAGGCGTGGTGGGTGGTGCAGGCTGGCTATA
TCACAGAAGATGACATCAAGATATGCACTTTGCCTGAGAAATGCGCTGTTGATAAGATCATCGATTCAGGCCCTCAACTCTCTGGATCAC
TAGATTACAATGTAGTACATAGTTTGTATAACAAAGGATTTATTTATCTGGATGTACCAATATCTGATGACAGTTGTATAGCAGTTCCAC
CTCTTGAAGGTTTTGTAATGAATCGAGTGCAAGGTGATTATTTTGAAACTCTACTCTATAAGATATTTGTTTCAATAGATGAGCACACAA
ATGTTGCAGAGCTTGCAAATGTCCTTGAGATTGACTTATCCCTGGTTAAGAATGCTGTTTCAATGTATTGCCGATTGGGCTTTGCCCATA
AGAAGGGACAAGTAATTAATTTGGATCAACTTCATTCATCATGGAAGAATGTTCCATCCGTAAACAGATTAAAGAGTACCTTAGATCCAC
AGAAGATGCTCTTGTCATGGGATGGAGGGGAAAGTAGGAGTCCTGTACAAGAAGCTTCATCGGCAACTGACACTGATACAAATAGTCAAG
AAGATCCAGCTGACACAGCCAGTGTAAGCAGCCTGAGTCTGTCTACAGGACACACGAAGCGCATCGCATTCCTGTTTGACTCCACTCTTA
CTGCCTTCTTAATGATGGGAAATCTTTCACCAAACTTGAAAAGTCATGCAGTCACAATGTTTGAAGTAGGCAAACTCTCAGATGAGTCTC
TGGACAGCTTTCTTATAGAACTAGAAAAGGTTCAGAGCACTGGTGAAGGAGAAGCACAGAGATATTTTGATCATGCACTTACTCTGAGAA
ACACAATACTGTTTCTGCGTCATAACAAAGATCTAGTTGCGCAAACTGCACAGCCAGACCAACCCAATTATGGTTTTCCTCTGGATCTCT
TACGCTGTGAAAGCCTTCTTGGTTTGGACCCTGCAACTTGCAGCAGAGTTCTAAACAAAAATTACACGCTGCTTGTTTCCATGGCTCCCC
TCACCAATGAAATCCGGCCTGTCAGCAGCTGCACCCCTCAGCATATTGGACCAGCTATCCCAGAAGTCAGCTCTGTCTGGTTTAAACTGT
ACATTTATCATGTCACTGGACAAGGACCACCATCCCTTTTATTGTCCAAAGGTACAAGACTTCGAAAACTGCCAGATATATTTCAGAGTT
ATGATCGATTGCTAATAACATCTTGGGGTCATGATCCTGGAGTAGTTCCTACCTCAAATGTGCTCACGATGTTGAATGATGCTTTAACAC
ATTCTGCAGTTTTAATTCAGGGGCATGGTCTGCATGGGATAGGAGAAACTGTCCATGTCCCATTTCCATTTGATGAAACAGAACTACAAG
GAGAGTTCACTCGTGTCAATATGGGTGTTCATAAAGCATTGCAGATACTAAGGAACAGAGTGGACTTACAGCATCTCTGTGGATATGTCA
CCATGTTGAATGCTTCCAGCCAACTTGCAGATAGAAAACTCAGTGATGCTTCTGATGAGAGAGGAGAACCTGATTTGGCTTCTGGCTCAG
ATGTAAATGGGAGTACAGAGTCATTTGAAATGGTCATTGAGGAAGCAACTATAGATTCAGCAACAAAGCAAACCTCTGGTGCCACAACAG
AAGCAGATTGGGTTCCTCTCGAGCTGTGCTTTGGAATTCCACTGTTCAGTTCCGAATTAAACCGGAAAGTTTGTAGGAAAATTGCTGCAC
ATGGCCTTTGCAGAAAAGAGAGCCTTCAAAACCTCTTACATTCCAGTAGAAAACTCTCTCTGCAAGTCCTTAACTTTGTTCACTCATTCC
AGGTAACAAAAACCAAAAAGTCCAAATGGTACTTGTACTGAGCTTTAAGTATGCACAACACTTCTGTGTTTGTTTTTGAGTCACCACAGC

>38137_38137_4_HYDIN-FAM91A1_HYDIN_chr16_71163543_ENST00000538248_FAM91A1_chr8_124786320_ENST00000521166_length(amino acids)=1201AA_BP=436
MESAGGFKLGMEPLSGGGVCEKKKLLKMTSRRLEESMGAVQMGLVNMFKGFQSKVLPPLSPKVVTEEEVNRMLTPSEFLKEMSLTTEQRL
AKTRLMCRPQIIELLDMGETTHQKFSGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLILRNNDKIPRLVKVVEESSPYFKVISPKDIGHK
VAPGVPSIFRILFTPEENKDYAHTLTCVTEREKFIVPIKARGARAILDFPDKLNFSTCPVKYSTQKILLVRNIGNKNAVFHIKTCRPFSI
EPAIGTLNVGESMQLEVEFEPQSVGDHSGRLIVCYDTGEKVFVSLYGAAIDMNIRLDKNSLTIEKTYISLANQRTITIHNRSNIIAHFLW
KVFATQQEEDREKYRACDDLIKEEKDETDEFFEECITDPLLREHLSVLSRTFANQRRLVQGDSKLFFNNVFTVEPLSLGNSQREYEKQVV
LYSIRNQLRYRNNLVKHVKKDERRYYEELLKYSRDHLMLYPYHLSDIMVKGLRITPFSYYTGIMEDIMNSEKSYDSLPNFTAADCLRLLG
IGRNQYIDLMNQCRSSKKFFRRKTARDLLPIKPVEIAIEAWWVVQAGYITEDDIKICTLPEKCAVDKIIDSGPQLSGSLDYNVVHSLYNK
GFIYLDVPISDDSCIAVPPLEGFVMNRVQGDYFETLLYKIFVSIDEHTNVAELANVLEIDLSLVKNAVSMYCRLGFAHKKGQVINLDQLH
SSWKNVPSVNRLKSTLDPQKMLLSWDGGESRSPVQEASSATDTDTNSQEDPADTASVSSLSLSTGHTKRIAFLFDSTLTAFLMMGNLSPN
LKSHAVTMFEVGKLSDESLDSFLIELEKVQSTGEGEAQRYFDHALTLRNTILFLRHNKDLVAQTAQPDQPNYGFPLDLLRCESLLGLDPA
TCSRVLNKNYTLLVSMAPLTNEIRPVSSCTPQHIGPAIPEVSSVWFKLYIYHVTGQGPPSLLLSKGTRLRKLPDIFQSYDRLLITSWGHD
PGVVPTSNVLTMLNDALTHSAVLIQGHGLHGIGETVHVPFPFDETELQGEFTRVNMGVHKALQILRNRVDLQHLCGYVTMLNASSQLADR
KLSDASDERGEPDLASGSDVNGSTESFEMVIEEATIDSATKQTSGATTEADWVPLELCFGIPLFSSELNRKVCRKIAAHGLCRKESLQNL

--------------------------------------------------------------
>38137_38137_5_HYDIN-FAM91A1_HYDIN_chr16_71163543_ENST00000541601_FAM91A1_chr8_124786320_ENST00000334705_length(transcript)=6498nt_BP=1305nt
AACGGACGGCAACAGCTCGGGCGGCGCATGGAGAGTGCGGGCGGCTTCAAGCTGGGTGAGAAAAAAAAATTACTAAAAATGACAAGTAGA
AGACTTGAGGAGTCCATGGGGGCTGTTCAGATGGGATTGGTCAATATGTTCAAAGGATTTCAAAGCAAGGTTTTGCCACCCCTGAGTCCA
AAGGTGGTTACAGAAGAAGAAGTAAACCGAATGCTTACACCCTCAGAGTTCCTGAAGGAAATGTCCCTGACCACCGAGCAGAGACTGGCA
AAAACACGTTTGATGTGCCGACCACAGATCATCGAACTCTTAGATATGGGGGAAACAACACATCAGAAGTTTTCAGGAATTGACCTGGAT
CAGGCATTATTCCAGCCCTTTCCATCAGAAATTATATTTCAGAACTACACTCCCTGTGAAGTCTATGAAGTTCCACTGATTTTGAGGAAC
AATGACAAAATTCCAAGGTTGGTGAAAGTTGTGGAAGAAAGTTCGCCTTACTTTAAAGTAATCAGCCCCAAAGATATTGGCCACAAAGTG
GCTCCTGGAGTGCCTTCCATATTCCGAATCCTCTTTACTCCAGAGGAGAACAAGGATTACGCCCATACGTTGACCTGTGTTACTGAAAGA
GAAAAGTTTATTGTACCCATCAAAGCTAGAGGGGCACGAGCCATTCTCGATTTTCCTGACAAGCTGAATTTTTCCACTTGTCCTGTCAAA
TACAGCACCCAGAAGATTCTGCTGGTACGAAACATTGGCAACAAAAATGCTGTATTTCACATCAAAACTTGTAGGCCTTTCTCTATAGAA
CCAGCTATTGGAACTCTTAATGTGGGAGAGTCCATGCAACTGGAAGTGGAGTTTGAGCCACAGAGTGTGGGCGATCACAGTGGAAGACTT
ATCGTGTGTTATGACACAGGTGAAAAGGTGTTTGTATCTCTCTATGGAGCTGCCATAGACATGAATATAAGGCTGGATAAGAATTCCTTG
ACCATCGAGAAAACCTACATATCTCTGGCCAATCAGCGAACTATAACCATTCACAATCGCAGTAATATCATTGCCCATTTCCTGTGGAAG
GTATTTGCTACCCAGCAAGAAGAGGACAGAGAAAAATATAGGGCCTGTGATGATCTGATCAAAGAGGAGAAGGATGAGACTGATGAGTTT
TTTGAAGAGTGCATTACTGATCCTTTACTCCGAGAACATCTTTCTGTTCTGTCCCGAACCTTTGCGAATCAGAGGAGGCTGGTGCAGGGA
GACAGCAAGCTGTTCTTCAATAACGTTTTCACTGTGGAGCCCCTGAGTCTTGGAAATTCACAGAGAGAATATGAAAAGCAGGTTGTCCTG
TACAGTATCCGCAATCAGTTACGATATAGAAATAACTTAGTTAAACATGTCAAGAAAGATGAACGCAGATACTATGAGGAACTGCTAAAG
TACAGCCGAGATCATCTCATGCTGTACCCTTACCATCTATCGGATATTATGGTGAAAGGCTTGAGGATAACACCATTTTCATATTATACT
GGGATTATGGAGGATATTATGAACAGTGAGAAAAGTTATGATTCATTGCCCAATTTTACTGCTGCTGACTGTCTAAGGCTTCTTGGCATA
GGAAGAAACCAGTATATTGATCTTATGAATCAGTGTAGATCATCAAAAAAATTCTTCAGAAGGAAAACAGCCCGTGATCTTCTACCAATA
AAGCCAGTGGAAATTGCCATAGAGGCGTGGTGGGTGGTGCAGGCTGGCTATATCACAGAAGATGACATCAAGATATGCACTTTGCCTGAG
AAATGCGCTGTTGATAAGATCATCGATTCAGGCCCTCAACTCTCTGGATCACTAGATTACAATGTAGTACATAGTTTGTATAACAAAGGA
TTTATTTATCTGGATGTACCAATATCTGATGACAGTTGTATAGCAGTTCCACCTCTTGAAGGTTTTGTAATGAATCGAGTGCAAGGTGAT
TATTTTGAAACTCTACTCTATAAGATATTTGTTTCAATAGATGAGCACACAAATGTTGCAGAGCTTGCAAATGTCCTTGAGATTGACTTA
TCCCTGGTTAAGAATGCTGTTTCAATGTATTGCCGATTGGGCTTTGCCCATAAGAAGGGACAAGTAATTAATTTGGATCAACTTCATTCA
TCATGGAAGAATGTTCCATCCGTAAACAGATTAAAGAGTACCTTAGATCCACAGAAGATGCTCTTGTCATGGGATGGAGGGGAAAGTAGG
AGTCCTGTACAAGAAGCTTCATCGGCAACTGACACTGATACAAATAGTCAAGAAGATCCAGCTGACACAGCCAGTGTAAGCAGCCTGAGT
CTGTCTACAGGACACACGAAGCGCATCGCATTCCTGTTTGACTCCACTCTTACTGCCTTCTTAATGATGGGAAATCTTTCACCAAACTTG
AAAAGTCATGCAGTCACAATGTTTGAAGTAGGCAAACTCTCAGATGAGTCTCTGGACAGCTTTCTTATAGAACTAGAAAAGGTTCAGAGC
ACTGGTGAAGGAGAAGCACAGAGATATTTTGATCATGCACTTACTCTGAGAAACACAATACTGTTTCTGCGTCATAACAAAGATCTAGTT
GCGCAAACTGCACAGCCAGACCAACCCAATTATGGTTTTCCTCTGGATCTCTTACGCTGTGAAAGCCTTCTTGGTTTGGACCCTGCAACT
TGCAGCAGAGTTCTAAACAAAAATTACACGCTGCTTGTTTCCATGGCTCCCCTCACCAATGAAATCCGGCCTGTCAGCAGCTGCACCCCT
CAGCATATTGGACCAGCTATCCCAGAAGTCAGCTCTGTCTGGTTTAAACTGTACATTTATCATGTCACTGGACAAGGACCACCATCCCTT
TTATTGTCCAAAGGTACAAGACTTCGAAAACTGCCAGATATATTTCAGAGTTATGATCGATTGCTAATAACATCTTGGGGTCATGATCCT
GGAGTAGTTCCTACCTCAAATGTGCTCACGATGTTGAATGATGCTTTAACACATTCTGCAGTTTTAATTCAGGGGCATGGTCTGCATGGG
ATAGGAGAAACTGTCCATGTCCCATTTCCATTTGATGAAACAGAACTACAAGGAGAGTTCACTCGTGTCAATATGGGTGTTCATAAAGCA
TTGCAGATACTAAGGAACAGAGTGGACTTACAGCATCTCTGTGGATATGTCACCATGTTGAATGCTTCCAGCCAACTTGCAGATAGAAAA
CTCAGTGATGCTTCTGATGAGAGAGGAGAACCTGATTTGGCTTCTGGCTCAGATGTAAATGGGAGTACAGAGTCATTTGAAATGGTCATT
GAGGAAGCAACTATAGATTCAGCAACAAAGCAAACCTCTGGTGCCACAACAGAAGCAGATTGGGTTCCTCTCGAGCTGTGCTTTGGAATT
CCACTGTTCAGTTCCGAATTAAACCGGAAAGTTTGTAGGAAAATTGCTGCACATGGCCTTTGCAGAAAAGAGAGCCTTCAAAACCTCTTA
CATTCCAGTAGAAAACTCTCTCTGCAAGTCCTTAACTTTGTTCACTCATTCCAGGAAGGTGCTTCAATATTGGATATTCACACAGAGCCC
AGTTTTTCAAGTTTGCTTTCACAGTCATCGTGTGCTGACATGGGTGTTCCACTTCCTGCAAAAAACTTAATATTTAAAGATGGTGTCTTA
TCAGAATGGAGTGGACGGTCACCTTCCTCACTTCTTATTGCTAATCTCCATTTGCAATAATTTGGTTACACCATTTGTTGCTCACACTTT
CTGCCTTTTTTCTTTCTTAACGTTAGCTTTATAGTGTCAGCCACTAAAAAGCATCCTGCTGCTGCAGTGCAATTCTTGCTTAACTAATAT
TAAAAGTTGGGGAACATATTCATGTTTTCTGAAGTTTTGCTCATTATTGCACATCTTATTGCGACAAAGTGCTTTTTAGCAGCCAGCACT
GTATTTTTTACCTTGAGACAATCTGCATTTCTTTTATAAAACTAAGTATATACTTTATAGGCTTTATGATGACTGTTATGTTTATAAGCA
GTCACTATGAAAATTGCAATGGTAATTTTATATGTTAGTTTATCAAACATAAATCTTGTTTAATTTTATATTTTGTTACCTATACTTTGG
GGGATCAAGGGAAGAGATGGAACTCTTCCTCTGAAAAGGCTTCTTGGTACTTAAAGTAGTAAAACTATAAAACAATAAACATCCAGTATT
GAGAGATGATATGATAGGGCATTATGAATTCCTATGGGTGTCTGTAAATTATGTATGTCAGTTGGACATTGTAGAAGGTATGTAAATCAG
CATAGTTGTGTATAACTTAACCTTGATTTATAAGGTCTTAAGATTATGACTATTCATTGACATCTCATGAGAAGCTTTAGAAGACTTTCT
ATTTTTAAACACCATTTATATGTGGACTTCTGTTGTCACTGACTTTGGGCTTTATATTTTCATAGAGTCTTTATGGAAAAAATAGAATTT
ATTTTCCACTCTTGTAGCTATAGCTGCTGCACACTTTCACCCTGATTTATTTTTTTGTTTCTTAGCTTTGATGTTTTCAAACCAAGGATT
GTGATTTTAGGTTAGAATTACATATTAGAAGCATTAAGACTATGTCTTTGGATCAGAATGCTTTAGTGATAAACCTACTTTGAAGACATA
CTCTTAAGCAATCTGGATCTTAAATTTATGTGAATACTTTTTTAGAAAATGATAAAGAAAAATGGAATTACTTCAAAGTGTTTCTTGAGT
CATTGATTCTTTTAGCATCTCAAATGTTAATTAGAATAATTGGAATCACTTTTTAGACTTTTCAAGTTACCTTCCTTGGGAAGTTTGTGC
AGTGTTATAGTTTAGTTTAGCTCCTCTTACAGGGTAATGGTTTGCTAGTTTAAAACTGTAACCAAACGAACTGGTCAGACAACATATATC
TAAAACACTTAAAATGTTAGGAAGTTTGGGAATGTTATAACCTAAACGTTTTTGCTGGTAACTTTTTGTTATTTATAGATATTTGTGTAT
TTAACATACATACTTCAGGAAATATATGCCTTTCCTAAAACTTAACCATGCATTCAATACCATGGCCTATCTATAGAATTGAATATTTTG
GACCATGTTATCTGTGGCACAGTCAGTGCTGTGTTTGAGGTAAATGCAGTAACGGTTAGTTTTCTACTTTGTCTTATAGAAGGTAGAAAC
CATGTGTATGTTATGTTTGTCTATAAAAGAAAAAATACTAATATTAAATAATTTCTTACGACTCTGAGTCACTCACTTATTTTTCCAATA
ATTGATATTGTACATTCCTAGTGCCATTAGGTATGTATGTATGTAACTTTTACAGTTTTTCAGCTGAAAGTTGTAAGTATTTTTTTTTTT
TGATCGGGGCTCTTTAATCTCATTTTAATTTCCTTTGTTTGAACTGTAGTTATTTTATTTATTCCTATATTAACCATCTAAACCAACTGT
AATGACATGTACACTAATACAGAATTGAACATTTGTAGTTGTTGGCAGTGAACCCAGTTGTTGGTGAATTTAAAGCTTAAAATATGGGAA
TGATTTGCTGCTATATTTCCTTTGAGAGAGAAAGGAGGAAGAAATAGAACCTAATAGTGATCATGAATTTTAGGGAAAGTACCGAAGAAC
CATGGGGTCCCCTCTGGTTTCTTGTGTTGAATGAGGCAAGGGTAATCATCTGATTCCGAGCTGAAGACCTCTGGTCCTCTTAAGGAGGGA
GAGTGCATTTTTAGAGCTTTTAGCAAAATGTGAAAAGCTGATGTTTGCGCCTTGCTTTGTGAATTTGGCTTTGTTTTACTTATACATTAA
CTCATGTAATCTCTTAAATCTTACAAGCATTGATCCATTTCAACAAAAAGGTAAATTTAAAATGCAGACTTTGTTATTTGCCAAAGAAGA
TTCATGAAAAATTTACGTCCAATTATTTTGCAAATAGTTAATTTCATTTGGCTTTTTACCATGTTCCTTCCTTTCTTTTTCCCGCTTCCT
TAATGTAATTTAAACCCTGGCAAACATTCTTTAGAAACCAAGAGGAAAGAAAGAACAAATATCAAAAAAGACATAGAATTTAATATTGAT
ACAATTTCACCTCTAAAATGGATTTGAAGAAATGCAACTTTATATCAAAAAATGTCATCTGATTTCCTTTGTTTCTTTTTTAAATTATGT
AATCAGATGATTTTATGTTTTTTTTTCAGGGGAGCGGAATATTGGTTTCTTTTACTTGTTGTTTTCAGTTTTCTCTGCCATTCATGTTTC
TTTTTTGTGTTCAGTGTTTCAAATACAATTTGTATTTAAGGATTTTAAAATACCAAACTGTAACTGAGTACAGTGGATCGTTTTCTGTTA
GGATGTTAATATTATACAATGAAATCTATAAAGTGTTGTCAATTTGATTATTGACACATATAACATGTTTACAAATAAACTGTGGTATTG

>38137_38137_5_HYDIN-FAM91A1_HYDIN_chr16_71163543_ENST00000541601_FAM91A1_chr8_124786320_ENST00000334705_length(amino acids)=1240AA_BP=426
MESAGGFKLGEKKKLLKMTSRRLEESMGAVQMGLVNMFKGFQSKVLPPLSPKVVTEEEVNRMLTPSEFLKEMSLTTEQRLAKTRLMCRPQ
IIELLDMGETTHQKFSGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLILRNNDKIPRLVKVVEESSPYFKVISPKDIGHKVAPGVPSIFR
ILFTPEENKDYAHTLTCVTEREKFIVPIKARGARAILDFPDKLNFSTCPVKYSTQKILLVRNIGNKNAVFHIKTCRPFSIEPAIGTLNVG
ESMQLEVEFEPQSVGDHSGRLIVCYDTGEKVFVSLYGAAIDMNIRLDKNSLTIEKTYISLANQRTITIHNRSNIIAHFLWKVFATQQEED
REKYRACDDLIKEEKDETDEFFEECITDPLLREHLSVLSRTFANQRRLVQGDSKLFFNNVFTVEPLSLGNSQREYEKQVVLYSIRNQLRY
RNNLVKHVKKDERRYYEELLKYSRDHLMLYPYHLSDIMVKGLRITPFSYYTGIMEDIMNSEKSYDSLPNFTAADCLRLLGIGRNQYIDLM
NQCRSSKKFFRRKTARDLLPIKPVEIAIEAWWVVQAGYITEDDIKICTLPEKCAVDKIIDSGPQLSGSLDYNVVHSLYNKGFIYLDVPIS
DDSCIAVPPLEGFVMNRVQGDYFETLLYKIFVSIDEHTNVAELANVLEIDLSLVKNAVSMYCRLGFAHKKGQVINLDQLHSSWKNVPSVN
RLKSTLDPQKMLLSWDGGESRSPVQEASSATDTDTNSQEDPADTASVSSLSLSTGHTKRIAFLFDSTLTAFLMMGNLSPNLKSHAVTMFE
VGKLSDESLDSFLIELEKVQSTGEGEAQRYFDHALTLRNTILFLRHNKDLVAQTAQPDQPNYGFPLDLLRCESLLGLDPATCSRVLNKNY
TLLVSMAPLTNEIRPVSSCTPQHIGPAIPEVSSVWFKLYIYHVTGQGPPSLLLSKGTRLRKLPDIFQSYDRLLITSWGHDPGVVPTSNVL
TMLNDALTHSAVLIQGHGLHGIGETVHVPFPFDETELQGEFTRVNMGVHKALQILRNRVDLQHLCGYVTMLNASSQLADRKLSDASDERG
EPDLASGSDVNGSTESFEMVIEEATIDSATKQTSGATTEADWVPLELCFGIPLFSSELNRKVCRKIAAHGLCRKESLQNLLHSSRKLSLQ

--------------------------------------------------------------
>38137_38137_6_HYDIN-FAM91A1_HYDIN_chr16_71163543_ENST00000541601_FAM91A1_chr8_124786320_ENST00000521166_length(transcript)=3692nt_BP=1305nt
AACGGACGGCAACAGCTCGGGCGGCGCATGGAGAGTGCGGGCGGCTTCAAGCTGGGTGAGAAAAAAAAATTACTAAAAATGACAAGTAGA
AGACTTGAGGAGTCCATGGGGGCTGTTCAGATGGGATTGGTCAATATGTTCAAAGGATTTCAAAGCAAGGTTTTGCCACCCCTGAGTCCA
AAGGTGGTTACAGAAGAAGAAGTAAACCGAATGCTTACACCCTCAGAGTTCCTGAAGGAAATGTCCCTGACCACCGAGCAGAGACTGGCA
AAAACACGTTTGATGTGCCGACCACAGATCATCGAACTCTTAGATATGGGGGAAACAACACATCAGAAGTTTTCAGGAATTGACCTGGAT
CAGGCATTATTCCAGCCCTTTCCATCAGAAATTATATTTCAGAACTACACTCCCTGTGAAGTCTATGAAGTTCCACTGATTTTGAGGAAC
AATGACAAAATTCCAAGGTTGGTGAAAGTTGTGGAAGAAAGTTCGCCTTACTTTAAAGTAATCAGCCCCAAAGATATTGGCCACAAAGTG
GCTCCTGGAGTGCCTTCCATATTCCGAATCCTCTTTACTCCAGAGGAGAACAAGGATTACGCCCATACGTTGACCTGTGTTACTGAAAGA
GAAAAGTTTATTGTACCCATCAAAGCTAGAGGGGCACGAGCCATTCTCGATTTTCCTGACAAGCTGAATTTTTCCACTTGTCCTGTCAAA
TACAGCACCCAGAAGATTCTGCTGGTACGAAACATTGGCAACAAAAATGCTGTATTTCACATCAAAACTTGTAGGCCTTTCTCTATAGAA
CCAGCTATTGGAACTCTTAATGTGGGAGAGTCCATGCAACTGGAAGTGGAGTTTGAGCCACAGAGTGTGGGCGATCACAGTGGAAGACTT
ATCGTGTGTTATGACACAGGTGAAAAGGTGTTTGTATCTCTCTATGGAGCTGCCATAGACATGAATATAAGGCTGGATAAGAATTCCTTG
ACCATCGAGAAAACCTACATATCTCTGGCCAATCAGCGAACTATAACCATTCACAATCGCAGTAATATCATTGCCCATTTCCTGTGGAAG
GTATTTGCTACCCAGCAAGAAGAGGACAGAGAAAAATATAGGGCCTGTGATGATCTGATCAAAGAGGAGAAGGATGAGACTGATGAGTTT
TTTGAAGAGTGCATTACTGATCCTTTACTCCGAGAACATCTTTCTGTTCTGTCCCGAACCTTTGCGAATCAGAGGAGGCTGGTGCAGGGA
GACAGCAAGCTGTTCTTCAATAACGTTTTCACTGTGGAGCCCCTGAGTCTTGGAAATTCACAGAGAGAATATGAAAAGCAGGTTGTCCTG
TACAGTATCCGCAATCAGTTACGATATAGAAATAACTTAGTTAAACATGTCAAGAAAGATGAACGCAGATACTATGAGGAACTGCTAAAG
TACAGCCGAGATCATCTCATGCTGTACCCTTACCATCTATCGGATATTATGGTGAAAGGCTTGAGGATAACACCATTTTCATATTATACT
GGGATTATGGAGGATATTATGAACAGTGAGAAAAGTTATGATTCATTGCCCAATTTTACTGCTGCTGACTGTCTAAGGCTTCTTGGCATA
GGAAGAAACCAGTATATTGATCTTATGAATCAGTGTAGATCATCAAAAAAATTCTTCAGAAGGAAAACAGCCCGTGATCTTCTACCAATA
AAGCCAGTGGAAATTGCCATAGAGGCGTGGTGGGTGGTGCAGGCTGGCTATATCACAGAAGATGACATCAAGATATGCACTTTGCCTGAG
AAATGCGCTGTTGATAAGATCATCGATTCAGGCCCTCAACTCTCTGGATCACTAGATTACAATGTAGTACATAGTTTGTATAACAAAGGA
TTTATTTATCTGGATGTACCAATATCTGATGACAGTTGTATAGCAGTTCCACCTCTTGAAGGTTTTGTAATGAATCGAGTGCAAGGTGAT
TATTTTGAAACTCTACTCTATAAGATATTTGTTTCAATAGATGAGCACACAAATGTTGCAGAGCTTGCAAATGTCCTTGAGATTGACTTA
TCCCTGGTTAAGAATGCTGTTTCAATGTATTGCCGATTGGGCTTTGCCCATAAGAAGGGACAAGTAATTAATTTGGATCAACTTCATTCA
TCATGGAAGAATGTTCCATCCGTAAACAGATTAAAGAGTACCTTAGATCCACAGAAGATGCTCTTGTCATGGGATGGAGGGGAAAGTAGG
AGTCCTGTACAAGAAGCTTCATCGGCAACTGACACTGATACAAATAGTCAAGAAGATCCAGCTGACACAGCCAGTGTAAGCAGCCTGAGT
CTGTCTACAGGACACACGAAGCGCATCGCATTCCTGTTTGACTCCACTCTTACTGCCTTCTTAATGATGGGAAATCTTTCACCAAACTTG
AAAAGTCATGCAGTCACAATGTTTGAAGTAGGCAAACTCTCAGATGAGTCTCTGGACAGCTTTCTTATAGAACTAGAAAAGGTTCAGAGC
ACTGGTGAAGGAGAAGCACAGAGATATTTTGATCATGCACTTACTCTGAGAAACACAATACTGTTTCTGCGTCATAACAAAGATCTAGTT
GCGCAAACTGCACAGCCAGACCAACCCAATTATGGTTTTCCTCTGGATCTCTTACGCTGTGAAAGCCTTCTTGGTTTGGACCCTGCAACT
TGCAGCAGAGTTCTAAACAAAAATTACACGCTGCTTGTTTCCATGGCTCCCCTCACCAATGAAATCCGGCCTGTCAGCAGCTGCACCCCT
CAGCATATTGGACCAGCTATCCCAGAAGTCAGCTCTGTCTGGTTTAAACTGTACATTTATCATGTCACTGGACAAGGACCACCATCCCTT
TTATTGTCCAAAGGTACAAGACTTCGAAAACTGCCAGATATATTTCAGAGTTATGATCGATTGCTAATAACATCTTGGGGTCATGATCCT
GGAGTAGTTCCTACCTCAAATGTGCTCACGATGTTGAATGATGCTTTAACACATTCTGCAGTTTTAATTCAGGGGCATGGTCTGCATGGG
ATAGGAGAAACTGTCCATGTCCCATTTCCATTTGATGAAACAGAACTACAAGGAGAGTTCACTCGTGTCAATATGGGTGTTCATAAAGCA
TTGCAGATACTAAGGAACAGAGTGGACTTACAGCATCTCTGTGGATATGTCACCATGTTGAATGCTTCCAGCCAACTTGCAGATAGAAAA
CTCAGTGATGCTTCTGATGAGAGAGGAGAACCTGATTTGGCTTCTGGCTCAGATGTAAATGGGAGTACAGAGTCATTTGAAATGGTCATT
GAGGAAGCAACTATAGATTCAGCAACAAAGCAAACCTCTGGTGCCACAACAGAAGCAGATTGGGTTCCTCTCGAGCTGTGCTTTGGAATT
CCACTGTTCAGTTCCGAATTAAACCGGAAAGTTTGTAGGAAAATTGCTGCACATGGCCTTTGCAGAAAAGAGAGCCTTCAAAACCTCTTA
CATTCCAGTAGAAAACTCTCTCTGCAAGTCCTTAACTTTGTTCACTCATTCCAGGTAACAAAAACCAAAAAGTCCAAATGGTACTTGTAC
TGAGCTTTAAGTATGCACAACACTTCTGTGTTTGTTTTTGAGTCACCACAGCAGCAAGATATGAAATAAACATTAATTTTATTGTACAAA

>38137_38137_6_HYDIN-FAM91A1_HYDIN_chr16_71163543_ENST00000541601_FAM91A1_chr8_124786320_ENST00000521166_length(amino acids)=1191AA_BP=426
MESAGGFKLGEKKKLLKMTSRRLEESMGAVQMGLVNMFKGFQSKVLPPLSPKVVTEEEVNRMLTPSEFLKEMSLTTEQRLAKTRLMCRPQ
IIELLDMGETTHQKFSGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLILRNNDKIPRLVKVVEESSPYFKVISPKDIGHKVAPGVPSIFR
ILFTPEENKDYAHTLTCVTEREKFIVPIKARGARAILDFPDKLNFSTCPVKYSTQKILLVRNIGNKNAVFHIKTCRPFSIEPAIGTLNVG
ESMQLEVEFEPQSVGDHSGRLIVCYDTGEKVFVSLYGAAIDMNIRLDKNSLTIEKTYISLANQRTITIHNRSNIIAHFLWKVFATQQEED
REKYRACDDLIKEEKDETDEFFEECITDPLLREHLSVLSRTFANQRRLVQGDSKLFFNNVFTVEPLSLGNSQREYEKQVVLYSIRNQLRY
RNNLVKHVKKDERRYYEELLKYSRDHLMLYPYHLSDIMVKGLRITPFSYYTGIMEDIMNSEKSYDSLPNFTAADCLRLLGIGRNQYIDLM
NQCRSSKKFFRRKTARDLLPIKPVEIAIEAWWVVQAGYITEDDIKICTLPEKCAVDKIIDSGPQLSGSLDYNVVHSLYNKGFIYLDVPIS
DDSCIAVPPLEGFVMNRVQGDYFETLLYKIFVSIDEHTNVAELANVLEIDLSLVKNAVSMYCRLGFAHKKGQVINLDQLHSSWKNVPSVN
RLKSTLDPQKMLLSWDGGESRSPVQEASSATDTDTNSQEDPADTASVSSLSLSTGHTKRIAFLFDSTLTAFLMMGNLSPNLKSHAVTMFE
VGKLSDESLDSFLIELEKVQSTGEGEAQRYFDHALTLRNTILFLRHNKDLVAQTAQPDQPNYGFPLDLLRCESLLGLDPATCSRVLNKNY
TLLVSMAPLTNEIRPVSSCTPQHIGPAIPEVSSVWFKLYIYHVTGQGPPSLLLSKGTRLRKLPDIFQSYDRLLITSWGHDPGVVPTSNVL
TMLNDALTHSAVLIQGHGLHGIGETVHVPFPFDETELQGEFTRVNMGVHKALQILRNRVDLQHLCGYVTMLNASSQLADRKLSDASDERG
EPDLASGSDVNGSTESFEMVIEEATIDSATKQTSGATTEADWVPLELCFGIPLFSSELNRKVCRKIAAHGLCRKESLQNLLHSSRKLSLQ

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Fusion Gene PPI Analysis for HYDIN-FAM91A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HYDIN-FAM91A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HYDIN-FAM91A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource