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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HYDIN-PSMD11 (FusionGDB2 ID:38138)

Fusion Gene Summary for HYDIN-PSMD11

check button Fusion gene summary
Fusion gene informationFusion gene name: HYDIN-PSMD11
Fusion gene ID: 38138
HgeneTgene
Gene symbol

HYDIN

PSMD11

Gene ID

54768

5717

Gene nameHYDIN axonemal central pair apparatus proteinproteasome 26S subunit, non-ATPase 11
SynonymsCILD5|HYDIN1|HYDIN2|PPP1R31Rpn6|S9|p44.5
Cytomap

16q22.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionhydrocephalus-inducing protein homologprotein phosphatase 1, regulatory subunit 3126S proteasome non-ATPase regulatory subunit 1126S proteasome regulatory subunit 926S proteasome regulatory subunit RPN626S proteasome regulatory subunit S926S proteasome regulatory subunit p44.5proteasome (prosome, macropain) 26S subunit, non-ATPase
Modification date2020031320200313
UniProtAcc

Q4G0P3

.
Ensembl transtripts involved in fusion geneENST00000393567, ENST00000448089, 
ENST00000288168, ENST00000321489, 
ENST00000393550, ENST00000448691, 
ENST00000538248, ENST00000541601, 
ENST00000543639, 		ENST00000261712, 
ENST00000457654, 
Fusion gene scores* DoF score3 X 4 X 3=3616 X 18 X 7=2016
# samples 421
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(21/2016*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HYDIN [Title/Abstract] AND PSMD11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHYDIN(71052032)-PSMD11(30791067), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HYDIN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PSMD11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A8IH-01AHYDINchr16

71052032

-PSMD11chr17

30791067

+
ChimerDB4PRADTCGA-KK-A8IHHYDINchr16

71052032

-PSMD11chr17

30791067

+


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Fusion Gene ORF analysis for HYDIN-PSMD11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393567ENST00000261712HYDINchr16

71052032

-PSMD11chr17

30791067

+
In-frameENST00000393567ENST00000457654HYDINchr16

71052032

-PSMD11chr17

30791067

+
In-frameENST00000448089ENST00000261712HYDINchr16

71052032

-PSMD11chr17

30791067

+
In-frameENST00000448089ENST00000457654HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000288168ENST00000261712HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000288168ENST00000457654HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000321489ENST00000261712HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000321489ENST00000457654HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000393550ENST00000261712HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000393550ENST00000457654HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000448691ENST00000261712HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000448691ENST00000457654HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000538248ENST00000261712HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000538248ENST00000457654HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000541601ENST00000261712HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000541601ENST00000457654HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000543639ENST00000261712HYDINchr16

71052032

-PSMD11chr17

30791067

+
intron-3CDSENST00000543639ENST00000457654HYDINchr16

71052032

-PSMD11chr17

30791067

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393567HYDINchr1671052032-ENST00000261712PSMD11chr1730791067+731237957938101243
ENST00000393567HYDINchr1671052032-ENST00000457654PSMD11chr1730791067+558637957938101243
ENST00000448089HYDINchr1671052032-ENST00000261712PSMD11chr1730791067+713436174536321195
ENST00000448089HYDINchr1671052032-ENST00000457654PSMD11chr1730791067+540836174536321195

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393567ENST00000261712HYDINchr1671052032-PSMD11chr1730791067+0.0001584730.99984145
ENST00000393567ENST00000457654HYDINchr1671052032-PSMD11chr1730791067+0.0003639560.99963605
ENST00000448089ENST00000261712HYDINchr1671052032-PSMD11chr1730791067+0.000252140.9997478
ENST00000448089ENST00000457654HYDINchr1671052032-PSMD11chr1730791067+0.0005197560.9994803

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Fusion Genomic Features for HYDIN-PSMD11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HYDINchr1671052031-PSMD11chr1730791066+2.05E-081
HYDINchr1671052031-PSMD11chr1730791066+2.05E-081
HYDINchr1671052031-PSMD11chr1730791066+2.05E-081
HYDINchr1671052031-PSMD11chr1730791066+2.05E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HYDIN-PSMD11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:71052032/chr17:30791067)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HYDIN

Q4G0P3

.
FUNCTION: Required for ciliary motility. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePSMD11chr16:71052032chr17:30791067ENST00000261712214224_3921061160.3333333333333DomainPCI
TgenePSMD11chr16:71052032chr17:30791067ENST00000457654213224_392106423.0DomainPCI

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHYDINchr16:71052032chr17:30791067ENST00000321489-1201908_193301018.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000321489-1202267_236501018.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000321489-1202504_254901018.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000393567-23861908_193312145122.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000393567-23862267_236512145122.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000393567-23862504_254912145122.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000448691-1201908_193301018.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000448691-1202267_236501018.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000448691-1202504_254901018.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000538248-1191908_19330951.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000538248-1192267_23650951.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000538248-1192504_25490951.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000541601-1191908_19330941.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000541601-1192267_23650941.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000541601-1192504_25490941.0Coiled coilOntology_term=ECO:0000255
HgeneHYDINchr16:71052032chr17:30791067ENST00000321489-1201975_198101018.0Compositional biasNote=Poly-Glu
HgeneHYDINchr16:71052032chr17:30791067ENST00000393567-23861975_198112145122.0Compositional biasNote=Poly-Glu
HgeneHYDINchr16:71052032chr17:30791067ENST00000448691-1201975_198101018.0Compositional biasNote=Poly-Glu
HgeneHYDINchr16:71052032chr17:30791067ENST00000538248-1191975_19810951.0Compositional biasNote=Poly-Glu
HgeneHYDINchr16:71052032chr17:30791067ENST00000541601-1191975_19810941.0Compositional biasNote=Poly-Glu


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Fusion Gene Sequence for HYDIN-PSMD11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>38138_38138_1_HYDIN-PSMD11_HYDIN_chr16_71052032_ENST00000393567_PSMD11_chr17_30791067_ENST00000261712_length(transcript)=7312nt_BP=3795nt
GCATGGAGAGTGCGGGCGGCTTCAAGCTGGGTATGGAGCCCCTCAGCGGCGGCGGGGTCTGTGAGTTGGACGCGGGGTCTTGGCGGGGAA
TGGAGGTAGAATAAACGTGGGACCCGGAGTGCACCAAGGTGAGAAAAAAAAATTACTAAAAATGACAAGTAGAAGACTTGAGGAGTCCAT
GGGGGCTGTTCAGATGGGATTGGTCAATATGTTCAAAGGATTTCAAAGCAAGGTTTTGCCACCCCTGAGTCCAAAGGTGGTTACAGAAGA
AGAAGTAAACCGAATGCTTACACCCTCAGAGTTCCTGAAGGAAATGTCCCTGACCACCGAGCAGAGACTGGCAAAAACACGTTTGATGTG
CCGACCACAGATCATCGAACTCTTAGATATGGGGGAAACAACACATCAGAAGTTTTCAGGAATTGACCTGGATCAGGCATTATTCCAGCC
CTTTCCATCAGAAATTATATTTCAGAACTACACTCCCTGTGAAGTCTATGAAGTTCCACTGATTTTGAGGAACAATGACAAAATTCCAAG
GTTGGTGAAAGTTGTGGAAGAAAGTTCGCCTTACTTTAAAGTAATCAGCCCCAAAGATATTGGCCACAAAGTGGCTCCTGGAGTGCCTTC
CATATTCCGAATCCTCTTTACTCCAGAGGAGAACAAGGATTACGCCCATACGTTGACCTGTGTTACTGAAAGAGAAAAGTTTATTGTACC
CATCAAAGCTAGAGGGGCACGAGCCATTCTCGATTTTCCTGACAAGCTGAATTTTTCCACTTGTCCTGTCAAATACAGCACCCAGAAGAT
TCTGCTGGTACGAAACATTGGCAACAAAAATGCTGTATTTCACATCAAAACTTGTAGGCCTTTCTCTATAGAACCAGCTATTGGAACTCT
TAATGTGGGAGAGTCCATGCAACTGGAAGTGGAGTTTGAGCCACAGAGTGTGGGCGATCACAGTGGAAGACTTATCGTGTGTTATGACAC
AGGTGAAAAGGTGTTTGTATCTCTCTATGGAGCTGCCATAGACATGAATATAAGGCTGGATAAGAATTCCTTGACCATCGAGAAAACCTA
CATATCTCTGGCCAATCAGCGAACTATAACCATTCACAATCGCAGTAATATCATTGCCCATTTCCTGTGGAAGGTATTTGCTACCCAGCA
AGAAGAGGACAGAGAAAAATATAGGGCCTGTGATGATCTGATCAAAGAGGAGAAGGATGAGACTGATGAGTTTTTTGAAGAGTGCATTAC
TGATCCTTTACTCCGAGAACATCTTTCTGTTCTGTCCCGAACCTTTGCGAATCAGAGGAGGCTGGTGCAGGGAGACAGCAAGCTGTTCTT
CAATAACGTTTTCACTGTGGAGCCCCTGGAAGGTGATGTCTGGCCCAACTCATCAGCTGAAATCACCGTGTACTTTAACCCACTAGAAGC
CAAGCTCTATCAACAGACCATTTACTGCGACATTTTAGGCCGAGAAATCCGTCTGCCCCTCCGAATCAAAGGGGAAGGCATGGGACCTAA
GATTCACTTCAACTTTGAATTGCTGGATATTGGGAAAGTTTTCACTGGATCTGCACATTGTTATGAGGCGATACTGTACAACAAAGGCAG
CATCGATGCTCTCTTCAACATGACCCCTCCAACTTCAGCTTTGGGGGCCTGCTTTGTTTTCAGTCCCAAGGAAGGCATCATTGAACCAAG
TGGAGTCCAAGCTATCCAGATCTCCTTCAGCTCTACCATCCTGGGAAACTTTGAAGAAGAGTTCCTGGTCAATGTCAATGGGTCACCTGA
GCCTGTGAAACTGACCATTAGAGGCTGTGTCATTGGACCTACCTTCCATTTTAATGTTCCAGCTCTGCACTTTGGTGATGTTTCCTTTGG
GTTTCCTCATACCTTGATATGTTCCCTCAATAATACCTCTTTGATCCCCATGACTTACAAACTGCGTATCCCTGGGGATGGCCTTGGCCA
TAAAAGCATTTCATATTGTGAGCAGCATGTGGACTACAAAAGACCATCTTGGACCAAGGAAGAAATATCCTCAATGAAACCAAAAGAATT
CACCATCTCTCCTGACTGTGGCACCATTCGCCCCCAGGGATTTGCTGCTATCAGGGTGACATTATGCTCCAACACTGTGCAGAAATACGA
GCTGGCACTCGTGGTGGACGTGGAGGGCATCGGAGAAGAGGTGCTGGCGCTCTTAATTACAGCAAGGTGTGTTGTACCTGCCCTCCACCT
GGTCAATACAGAGGTGGACTTTGGGCACTGCTTCCTGAAGTACCCGTATGAGAAAACACTCCAGCTTGCCAATCAAGATGACCTCCCAGG
ATTCTATGAGGTCCAGCCTCAGGTGTGTGAGGAGGTGCCTACTGTGCTGTTTTCCAGCCCCACCCCCAGCGGGGTCATCTCCCCAAGCAG
CACCATCCACATACCACTGGTCCTGGAGACCCAGGTCACTGGAGAACACAGATCCACGGTTTACATCTCAATCTTTGGGAGCCAGGACCC
CCCTTTGGTATGTCACTTAAAGAGCGCTGGAGAAGGCCCAGTTATCTACGTCCATCCCAATCAAGTGGACTTCGGGAATATCTACGTCCT
AAAAGACTCTTCCAGGATTCTCAACCTATGCAACCAGTCCTTCATTCCCGCATTTTTCCAGGCACACATGGCACACAAAAAATCCCTTTG
GACGATTGAACCCAATGAAGGCATGGTTCCTCCAGAAACTGATGTTCAACTGGCACTGACCGCCAACCTGAATGACACACTGACATTCAA
GGACTGTGTTATTTTGGACATTGAAAATAGCAGTACCTATCGGATTCCTGTTCAGGCTTCCGGAACTGGTTCCACTATTGTTTCAGATAA
GCCCTTTGCTCCAGAACTCAATTTGGGGGCACATTTTAGCCTGGATACCCACTATTACCACTTTAAGTTGATCAACAAGGGACGTCGGAT
CCAACAGTTGTTCTGGATGAATGATAGCTTCCGACCCCAGGCCAAGCTGAGTAAGAAGGGCCGGGTTAAGAAGGGACATGCTCATGTCCA
ACCCCAGCCCAGTGGCTCTCAGGAGCCCAGGGATCCACAGAGCCCCGTGTTTCATCTCCACCCCGCCAGCATGGAGCTGTACCCAGGCCA
GGCAATTGATGTGATACTCGAAGGCTATTCTGCTACTCCCAGGATAGTGAAAGAGAAGCTGGTGTGCCACGCCATCATCGGGGCACAGAA
GGGGAAGAGCTTGGTGATGGCTGTGAACATCACCTGTGAGTTCGTCGCACCTCTCATCCAGCTCTCCACCAAGCAGCTCATCTACCGACT
GGAGAAGAAACCTAACAGTATCCTGAAACCTGATTACCAGCCCTTGGCCATAAAGAACATTTCCACCCTGCCCGTGAACTTGTTGCTGTC
AACATCTGGACCCTTCTTTATATGTGAGACTGATAAATCCCTGCTGCCGGCAACTCCTGAGCCTATTAAACTGGAAATTGATGAAGAAAA
AAACCTGCTGATCAAGTTTGACCCTTCCTACAGAAACGATCTGAACAACTGGGTGGCAGAAGAAATTCTAGCAATTAAGTATGTGGAACA
CCCTCAGATAGACAGCCTGGACCTGCGCGGAGAAGTGCATTACCCCAACCTCAGCTTTGAGACAAAGGAGCTGGATTTTGGCTGCATCCT
GAACGATACTGAGCTCATTCGCTACGTTACCATCACCAACTGCAGTCCGTTGGTTGTGAAGTTTCGCTGGTTCTTCTTGGTGAATGATGA
GGAAAATCAGATAAGGTCGAGCTGTGTTTAGAGTGCATCGAATGGGCCAAGTCAGAGAAAAGAACTTTCTTACGCCAAGCTTTGGAGGCA
AGACTGGTGTCTTTGTACTTTGATACCAAGAGGTACCAGGAAGCATTGCATTTGGGTTCTCAGCTGCTGCGGGAGTTGAAAAAGATGGAC
GACAAAGCTCTTTTGGTGGAAGTACAGCTTTTAGAAAGCAAAACATACCATGCCCTGAGCAACCTGCCGAAAGCCCGAGCTGCCTTAACT
TCTGCTCGAACCACAGCAAATGCCATCTACTGCCCCCCTAAATTGCAGGCCACCTTGGACATGCAGTCGGGTATTATCCATGCAGCAGAA
GAGAAGGACTGGAAAACTGCGTACTCATACTTCTATGAGGCATTTGAGGGTTATGACTCCATCGACAGCCCCAAGGCCATCACATCTCTG
AAGTACATGTTGCTGTGCAAAATCATGCTCAACACCCCAGAAGATGTCCAGGCTTTGGTGAGCGGGAAGCTTGCACTTCGGTATGCAGGG
AGGCAGACAGAAGCATTAAAATGCGTGGCTCAGGCTAGCAAGAACAGATCACTGGCAGATTTTGAAAAGGCTCTGACAGATTACCGGGCA
GAGCTCCGGGATGACCCAATCATCAGCACACACTTGGCCAAGTTGTATGATAACTTACTAGAACAGAATCTGATCCGAGTCATTGAGCCT
TTTTCCAGAGTACAGATTGAACACATATCTAGTCTCATCAAACTCTCCAAGGCCGACGTGGAAAGGAAATTATCACAGATGATTCTTGAC
AAGAAATTTCATGGGATTTTGGACCAGGGGGAGGGTGTCCTGATTATTTTCGATGAACCCCCAGTAGATAAAACTTACGAAGCTGCTCTG
GAAACAATTCAGAACATGAGCAAAGTAGTGGATTCCCTCTACAACAAAGCCAAGAAACTGACATAGAGTTGGATCTGTAGCGGTCCTTTG
GAGAGTGTGTGTGGCGGGAGAGTGAAACCTTGGGGGAAAATGCTAGGAGATTCTTTTTTCTTTTTGTTCTACTTTTCGCTCGGAAAGTTT
TTAAATCCTCATTTGGTGCATCTGTATTCCAGCCAATAGGTGTGCCAGTTTTCATGTAATCTTTACTGGCCCAACTTGGGAGTGGGGAAA
TTGCTTAAAAAAAAAGAAAAAGAAAAAAAAAAAGATTATTCTAAATAAAAGGAAAAAGGCTTACACTACCTAAAGCTGTGCTCTCTGCCT
CCTGGGAGAGGGCCGCAAAGCCAGGCACCCCGCCAACCACTGGGGGTCCTAATCCACCTGCTGGGCATCACCTCTCCTCCTCCTCAGAAT
TGGGTGTTTGCTGACCATCAAAAGCAATGACTTTTTATTCTGTTTGTACTGAACCAAAACAAACAACTGTGTATAGACTGCTGTTTTCTT
TTTTATTTGAAATGAGGCATTTTGGTGTTCTTTCCCCTACCATACGGCCTGTCTGCCCTTCCCTCCCCACATTGGCTCCAGCAGAGTAGC
CGAAGGTCCTGCCGCCGCCGCCACCACCACCACCACTGCAGCAACAACAGCAGCAGCAGCAGCAGCGCCTGCATAGCTCCACTCTGACCT
GTGAAGGAATGGGGATGAGGCCAGGAGCTAGTGTCTACCACGGCCACACAGGGAGCAGTGTGGGCCCTTAGCCCCCAAGGGGCCTGCTAT
GCATGTGGCTTTTTTTTTTTTTTTAAACACAGTAAACTAGATTAGTCGTCAGTGTTTTAATTGCCCCTCTTCTCCTCTCCTGCATTCCTC
TCCTCTCTTCTTTCCTCTCTGTCCCTTCTCTTTCCCCTCTCAACCAGGAGACCATCATGTCTCTCTGCCTTCCTCCTCTCCCCTCCAGGG
GAGTCAGGCTGTCTGTGAAAGCCATGAGCTTCTCTCCCTCTCCCACTCCTCCTCTCCTACTTTCAGATGGATTTATTCCTTTTTTAAACA
ATGAACATCGGAAATGAGACTGTGGGGTGTGGTTTCTCTCTCTCTTTTTTTTTTAATTTTCTTTGTTGGGTTTTTGAGCAACCTCATGTC
CCCTTCCCAGGGAGCTTTTTAATTTACCTCTTAGAACTCAAGTGGATGGGAAGTAGAGCACTATGTGTCAGTATGCTTTGTTTTCTGACA
CGATTACACAGCGAGGCTTTAATGCCATTTGGGTAGGTGAGCTTCTGCACTTCTGTTGTGCTGAACTGTATTTTCTTCTCTCATCTCCTC
TTTGTCTTTTTCTCTTTTCCTCTCCTTCCTGCCTTCTTCTGCTGGCCTCCTTTTCTCTTTCTTTACCTTCCTTGGATTATCCTTCCAGGT
TTTCATAATAAATTTATATTTTGTAAAAGGATTTTGTTGTACCAGGTTTTGCATCCTCACTGAATCTGACTGGCTTTTATTTTCCTCTCC
AAAATCAGGTTTTTGTTCTCAACATCTTTCCCCATCATGTCTAGTCACTGTTTTGGTTTTGGCACCATCAGTATCAAATGTACAAACGGT
TCTTGCTAACCAACACCAGGTATATCTGATGTTCAGATGAGTTCCAATAAAAATAATTTTTTTTTTTTTCAAAAGGTGTCTTTTTCTTGA
GTGCTGGAGGGCTTCCAAGCAAGTCCAGACAGCTCTGTGTGGCCCCACACTAGTCTAGCTCTCATCTGGCCAAAGCTGTTATCTCATTTG
TGTAATGGGAGTCCTTAAGGTAAATTTGGGGTCCAAACTTGGAGGGCTTTGGGGGCAAGAAAGTTGGTGTGTGAGTTCTGAGGTTGGAAA
TGAGTTCAGGTGTCTTCTTCCAGGGCAGCATGGTCCAGTGAGCACATGTAAGTTTGGGCAGTAGATCCTCTGAGCCTACTTTCTCTTCTA
CTCAGTGAGGATGCTGCTTCCTTGGCAGGTGATTGTGATGTGAAGCTTAGTAAGTCATAGACGTGCAGGTGTCTGGAGAGTCCTGACATG
CAGTTGTGGTTTCGTTTCCTTTTGGAATCTTCAAAGGCAGCGATTTTCATATTGCCTCACACCCTGGCGGGGGCGGGGGGCTCTGGGACC
ACTGGGGGACCTGCTAAATCCTCTTCAGTCTGAGCAGTTCAGCCATTGTCAGTTTTAGTATTGTGTCTCTGTATTTCACTTGCAGAAAGA
GCTTTGCTTCTATAAAGGACTTTAAAAAGTACTCCAAAGAGATCTAGTTTTGGAGTAGAGGGGAGATGTTTTCTCAAACTTAGGGCAGTC
CTGAGATGCTCAGGCAGTAGCCCTTTTCTCAGTTCCCTTTGCGGGTCTTGGTCAGATGATGCCCTCTAGACCCGTGCTGTCCAATATGTA
GCCGCTAGCCATGTGCAGCTGTCAGGCCCTTGCAACGTGGCTGGTTCGAGCTGTGATACACTGCAAGTGTAAACACAAACCAGACTTCGA
AGGCTTAGTATGATAACAAAAGAAAAGGAGTGTAAAATATGTCAATAACTTTTTTATATATGTGTTGAAATATTTTGGGTATTGGGTTAA

>38138_38138_1_HYDIN-PSMD11_HYDIN_chr16_71052032_ENST00000393567_PSMD11_chr17_30791067_ENST00000261712_length(amino acids)=1243AA_BP=
MAGNGGRINVGPGVHQGEKKKLLKMTSRRLEESMGAVQMGLVNMFKGFQSKVLPPLSPKVVTEEEVNRMLTPSEFLKEMSLTTEQRLAKT
RLMCRPQIIELLDMGETTHQKFSGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLILRNNDKIPRLVKVVEESSPYFKVISPKDIGHKVAP
GVPSIFRILFTPEENKDYAHTLTCVTEREKFIVPIKARGARAILDFPDKLNFSTCPVKYSTQKILLVRNIGNKNAVFHIKTCRPFSIEPA
IGTLNVGESMQLEVEFEPQSVGDHSGRLIVCYDTGEKVFVSLYGAAIDMNIRLDKNSLTIEKTYISLANQRTITIHNRSNIIAHFLWKVF
ATQQEEDREKYRACDDLIKEEKDETDEFFEECITDPLLREHLSVLSRTFANQRRLVQGDSKLFFNNVFTVEPLEGDVWPNSSAEITVYFN
PLEAKLYQQTIYCDILGREIRLPLRIKGEGMGPKIHFNFELLDIGKVFTGSAHCYEAILYNKGSIDALFNMTPPTSALGACFVFSPKEGI
IEPSGVQAIQISFSSTILGNFEEEFLVNVNGSPEPVKLTIRGCVIGPTFHFNVPALHFGDVSFGFPHTLICSLNNTSLIPMTYKLRIPGD
GLGHKSISYCEQHVDYKRPSWTKEEISSMKPKEFTISPDCGTIRPQGFAAIRVTLCSNTVQKYELALVVDVEGIGEEVLALLITARCVVP
ALHLVNTEVDFGHCFLKYPYEKTLQLANQDDLPGFYEVQPQVCEEVPTVLFSSPTPSGVISPSSTIHIPLVLETQVTGEHRSTVYISIFG
SQDPPLVCHLKSAGEGPVIYVHPNQVDFGNIYVLKDSSRILNLCNQSFIPAFFQAHMAHKKSLWTIEPNEGMVPPETDVQLALTANLNDT
LTFKDCVILDIENSSTYRIPVQASGTGSTIVSDKPFAPELNLGAHFSLDTHYYHFKLINKGRRIQQLFWMNDSFRPQAKLSKKGRVKKGH
AHVQPQPSGSQEPRDPQSPVFHLHPASMELYPGQAIDVILEGYSATPRIVKEKLVCHAIIGAQKGKSLVMAVNITCEFVAPLIQLSTKQL
IYRLEKKPNSILKPDYQPLAIKNISTLPVNLLLSTSGPFFICETDKSLLPATPEPIKLEIDEEKNLLIKFDPSYRNDLNNWVAEEILAIK

--------------------------------------------------------------
>38138_38138_2_HYDIN-PSMD11_HYDIN_chr16_71052032_ENST00000393567_PSMD11_chr17_30791067_ENST00000457654_length(transcript)=5586nt_BP=3795nt
GCATGGAGAGTGCGGGCGGCTTCAAGCTGGGTATGGAGCCCCTCAGCGGCGGCGGGGTCTGTGAGTTGGACGCGGGGTCTTGGCGGGGAA
TGGAGGTAGAATAAACGTGGGACCCGGAGTGCACCAAGGTGAGAAAAAAAAATTACTAAAAATGACAAGTAGAAGACTTGAGGAGTCCAT
GGGGGCTGTTCAGATGGGATTGGTCAATATGTTCAAAGGATTTCAAAGCAAGGTTTTGCCACCCCTGAGTCCAAAGGTGGTTACAGAAGA
AGAAGTAAACCGAATGCTTACACCCTCAGAGTTCCTGAAGGAAATGTCCCTGACCACCGAGCAGAGACTGGCAAAAACACGTTTGATGTG
CCGACCACAGATCATCGAACTCTTAGATATGGGGGAAACAACACATCAGAAGTTTTCAGGAATTGACCTGGATCAGGCATTATTCCAGCC
CTTTCCATCAGAAATTATATTTCAGAACTACACTCCCTGTGAAGTCTATGAAGTTCCACTGATTTTGAGGAACAATGACAAAATTCCAAG
GTTGGTGAAAGTTGTGGAAGAAAGTTCGCCTTACTTTAAAGTAATCAGCCCCAAAGATATTGGCCACAAAGTGGCTCCTGGAGTGCCTTC
CATATTCCGAATCCTCTTTACTCCAGAGGAGAACAAGGATTACGCCCATACGTTGACCTGTGTTACTGAAAGAGAAAAGTTTATTGTACC
CATCAAAGCTAGAGGGGCACGAGCCATTCTCGATTTTCCTGACAAGCTGAATTTTTCCACTTGTCCTGTCAAATACAGCACCCAGAAGAT
TCTGCTGGTACGAAACATTGGCAACAAAAATGCTGTATTTCACATCAAAACTTGTAGGCCTTTCTCTATAGAACCAGCTATTGGAACTCT
TAATGTGGGAGAGTCCATGCAACTGGAAGTGGAGTTTGAGCCACAGAGTGTGGGCGATCACAGTGGAAGACTTATCGTGTGTTATGACAC
AGGTGAAAAGGTGTTTGTATCTCTCTATGGAGCTGCCATAGACATGAATATAAGGCTGGATAAGAATTCCTTGACCATCGAGAAAACCTA
CATATCTCTGGCCAATCAGCGAACTATAACCATTCACAATCGCAGTAATATCATTGCCCATTTCCTGTGGAAGGTATTTGCTACCCAGCA
AGAAGAGGACAGAGAAAAATATAGGGCCTGTGATGATCTGATCAAAGAGGAGAAGGATGAGACTGATGAGTTTTTTGAAGAGTGCATTAC
TGATCCTTTACTCCGAGAACATCTTTCTGTTCTGTCCCGAACCTTTGCGAATCAGAGGAGGCTGGTGCAGGGAGACAGCAAGCTGTTCTT
CAATAACGTTTTCACTGTGGAGCCCCTGGAAGGTGATGTCTGGCCCAACTCATCAGCTGAAATCACCGTGTACTTTAACCCACTAGAAGC
CAAGCTCTATCAACAGACCATTTACTGCGACATTTTAGGCCGAGAAATCCGTCTGCCCCTCCGAATCAAAGGGGAAGGCATGGGACCTAA
GATTCACTTCAACTTTGAATTGCTGGATATTGGGAAAGTTTTCACTGGATCTGCACATTGTTATGAGGCGATACTGTACAACAAAGGCAG
CATCGATGCTCTCTTCAACATGACCCCTCCAACTTCAGCTTTGGGGGCCTGCTTTGTTTTCAGTCCCAAGGAAGGCATCATTGAACCAAG
TGGAGTCCAAGCTATCCAGATCTCCTTCAGCTCTACCATCCTGGGAAACTTTGAAGAAGAGTTCCTGGTCAATGTCAATGGGTCACCTGA
GCCTGTGAAACTGACCATTAGAGGCTGTGTCATTGGACCTACCTTCCATTTTAATGTTCCAGCTCTGCACTTTGGTGATGTTTCCTTTGG
GTTTCCTCATACCTTGATATGTTCCCTCAATAATACCTCTTTGATCCCCATGACTTACAAACTGCGTATCCCTGGGGATGGCCTTGGCCA
TAAAAGCATTTCATATTGTGAGCAGCATGTGGACTACAAAAGACCATCTTGGACCAAGGAAGAAATATCCTCAATGAAACCAAAAGAATT
CACCATCTCTCCTGACTGTGGCACCATTCGCCCCCAGGGATTTGCTGCTATCAGGGTGACATTATGCTCCAACACTGTGCAGAAATACGA
GCTGGCACTCGTGGTGGACGTGGAGGGCATCGGAGAAGAGGTGCTGGCGCTCTTAATTACAGCAAGGTGTGTTGTACCTGCCCTCCACCT
GGTCAATACAGAGGTGGACTTTGGGCACTGCTTCCTGAAGTACCCGTATGAGAAAACACTCCAGCTTGCCAATCAAGATGACCTCCCAGG
ATTCTATGAGGTCCAGCCTCAGGTGTGTGAGGAGGTGCCTACTGTGCTGTTTTCCAGCCCCACCCCCAGCGGGGTCATCTCCCCAAGCAG
CACCATCCACATACCACTGGTCCTGGAGACCCAGGTCACTGGAGAACACAGATCCACGGTTTACATCTCAATCTTTGGGAGCCAGGACCC
CCCTTTGGTATGTCACTTAAAGAGCGCTGGAGAAGGCCCAGTTATCTACGTCCATCCCAATCAAGTGGACTTCGGGAATATCTACGTCCT
AAAAGACTCTTCCAGGATTCTCAACCTATGCAACCAGTCCTTCATTCCCGCATTTTTCCAGGCACACATGGCACACAAAAAATCCCTTTG
GACGATTGAACCCAATGAAGGCATGGTTCCTCCAGAAACTGATGTTCAACTGGCACTGACCGCCAACCTGAATGACACACTGACATTCAA
GGACTGTGTTATTTTGGACATTGAAAATAGCAGTACCTATCGGATTCCTGTTCAGGCTTCCGGAACTGGTTCCACTATTGTTTCAGATAA
GCCCTTTGCTCCAGAACTCAATTTGGGGGCACATTTTAGCCTGGATACCCACTATTACCACTTTAAGTTGATCAACAAGGGACGTCGGAT
CCAACAGTTGTTCTGGATGAATGATAGCTTCCGACCCCAGGCCAAGCTGAGTAAGAAGGGCCGGGTTAAGAAGGGACATGCTCATGTCCA
ACCCCAGCCCAGTGGCTCTCAGGAGCCCAGGGATCCACAGAGCCCCGTGTTTCATCTCCACCCCGCCAGCATGGAGCTGTACCCAGGCCA
GGCAATTGATGTGATACTCGAAGGCTATTCTGCTACTCCCAGGATAGTGAAAGAGAAGCTGGTGTGCCACGCCATCATCGGGGCACAGAA
GGGGAAGAGCTTGGTGATGGCTGTGAACATCACCTGTGAGTTCGTCGCACCTCTCATCCAGCTCTCCACCAAGCAGCTCATCTACCGACT
GGAGAAGAAACCTAACAGTATCCTGAAACCTGATTACCAGCCCTTGGCCATAAAGAACATTTCCACCCTGCCCGTGAACTTGTTGCTGTC
AACATCTGGACCCTTCTTTATATGTGAGACTGATAAATCCCTGCTGCCGGCAACTCCTGAGCCTATTAAACTGGAAATTGATGAAGAAAA
AAACCTGCTGATCAAGTTTGACCCTTCCTACAGAAACGATCTGAACAACTGGGTGGCAGAAGAAATTCTAGCAATTAAGTATGTGGAACA
CCCTCAGATAGACAGCCTGGACCTGCGCGGAGAAGTGCATTACCCCAACCTCAGCTTTGAGACAAAGGAGCTGGATTTTGGCTGCATCCT
GAACGATACTGAGCTCATTCGCTACGTTACCATCACCAACTGCAGTCCGTTGGTTGTGAAGTTTCGCTGGTTCTTCTTGGTGAATGATGA
GGAAAATCAGATAAGGTCGAGCTGTGTTTAGAGTGCATCGAATGGGCCAAGTCAGAGAAAAGAACTTTCTTACGCCAAGCTTTGGAGGCA
AGACTGGTGTCTTTGTACTTTGATACCAAGAGGTACCAGGAAGCATTGCATTTGGGTTCTCAGCTGCTGCGGGAGTTGAAAAAGATGGAC
GACAAAGCTCTTTTGGTGGAAGTACAGCTTTTAGAAAGCAAAACATACCATGCCCTGAGCAACCTGCCGAAAGCCCGAGCTGCCTTAACT
TCTGCTCGAACCACAGCAAATGCCATCTACTGCCCCCCTAAATTGCAGGCCACCTTGGACATGCAGTCGGGTATTATCCATGCAGCAGAA
GAGAAGGACTGGAAAACTGCGTACTCATACTTCTATGAGGCATTTGAGGGTTATGACTCCATCGACAGCCCCAAGGCCATCACATCTCTG
AAGTACATGTTGCTGTGCAAAATCATGCTCAACACCCCAGAAGATGTCCAGGCTTTGGTGAGCGGGAAGCTTGCACTTCGGTATGCAGGG
AGGCAGACAGAAGCATTAAAATGCGTGGCTCAGGCTAGCAAGAACAGATCACTGGCAGATTTTGAAAAGGCTCTGACAGATTACCGGGCA
GAGCTCCGGGATGACCCAATCATCAGCACACACTTGGCCAAGTTGTATGATAACTTACTAGAACAGAATCTGATCCGAGTCATTGAGCCT
TTTTCCAGAGTACAGATTGAACACATATCTAGTCTCATCAAACTCTCCAAGGCCGACGTGGAAAGGAAATTATCACAGATGATTCTTGAC
AAGAAATTTCATGGGATTTTGGACCAGGGGGAGGGTGTCCTGATTATTTTCGATGAACCCCCAGTAGATAAAACTTACGAAGCTGCTCTG
GAAACAATTCAGAACATGAGCAAAGTAGTGGATTCCCTCTACAACAAAGCCAAGAAACTGACATAGGTGAGTGCTGGCTTCAGGACCCCA
GGGCTGGGCAGCTCTGTCTTCTGCGTGTCGAGACTGAAAACCTCCTCCTGGTGTCCTCATGGCTTCCTGATTGACACTGCTCTGTCTTCT
CTTGCAGAGTTGGATCTGTAGCGGTCCTTTGGAGAGTGTGTGTGGCGGGAGAGTGAAACCTTGGGGGAAAATGCTAGGAGATTCTTTTTT
CTTTTTGTTCTACTTTTCGCTCGGAAAGTTTTTAAATCCTCATTTGGTGCATCTGTATTCCAGCCAATAGGTGTGCCAGTTTTCATGTAA
TCTTTACTGGCCCAACTTGGGAGTGGGGAAATTGCTTAAAAAAAAAGAAAAAGAAAAAAAAAAAGATTATTCTAAATAAAAGGAAAAAGG
CTTACACTACCTAAAGCTGTGCTCTCTGCCTCCTGGGAGAGGGCCGCAAAGCCAGGCACCCCGCCAACCACTGGGGGTCCTAATCCACCT
GCTGGGCATCACCTCTCCTCCTCCTCAGAATTGGGTGTTTGCTGACCATCAAAAGCAATGACTTTTTATTCTGTTTGTACTGAACCAAAA
CAAACAACTGTGTATAGACTGCTGTTTTCTTTTTTATTTGAAATGAGGCATTTTGGTGTTCTTTCCCCTACCATACGGCCTGTCTGCCCT
TCCCTCCCCACATTGGCTCCAGCAGAGTAGCCGAAGGTCCTGCCGCCGCCGCCACCACCACCACCACTGCAGCAACAACAGCAGCAGCAG
CAGCAGCGCCTGCATAGCTCCACTCTGACCTGTGAAGGAATGGGGATGAGGCCAGGAGCTAGTGTCTACCACGGCCACACAGGGAGCAGT

>38138_38138_2_HYDIN-PSMD11_HYDIN_chr16_71052032_ENST00000393567_PSMD11_chr17_30791067_ENST00000457654_length(amino acids)=1243AA_BP=
MAGNGGRINVGPGVHQGEKKKLLKMTSRRLEESMGAVQMGLVNMFKGFQSKVLPPLSPKVVTEEEVNRMLTPSEFLKEMSLTTEQRLAKT
RLMCRPQIIELLDMGETTHQKFSGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLILRNNDKIPRLVKVVEESSPYFKVISPKDIGHKVAP
GVPSIFRILFTPEENKDYAHTLTCVTEREKFIVPIKARGARAILDFPDKLNFSTCPVKYSTQKILLVRNIGNKNAVFHIKTCRPFSIEPA
IGTLNVGESMQLEVEFEPQSVGDHSGRLIVCYDTGEKVFVSLYGAAIDMNIRLDKNSLTIEKTYISLANQRTITIHNRSNIIAHFLWKVF
ATQQEEDREKYRACDDLIKEEKDETDEFFEECITDPLLREHLSVLSRTFANQRRLVQGDSKLFFNNVFTVEPLEGDVWPNSSAEITVYFN
PLEAKLYQQTIYCDILGREIRLPLRIKGEGMGPKIHFNFELLDIGKVFTGSAHCYEAILYNKGSIDALFNMTPPTSALGACFVFSPKEGI
IEPSGVQAIQISFSSTILGNFEEEFLVNVNGSPEPVKLTIRGCVIGPTFHFNVPALHFGDVSFGFPHTLICSLNNTSLIPMTYKLRIPGD
GLGHKSISYCEQHVDYKRPSWTKEEISSMKPKEFTISPDCGTIRPQGFAAIRVTLCSNTVQKYELALVVDVEGIGEEVLALLITARCVVP
ALHLVNTEVDFGHCFLKYPYEKTLQLANQDDLPGFYEVQPQVCEEVPTVLFSSPTPSGVISPSSTIHIPLVLETQVTGEHRSTVYISIFG
SQDPPLVCHLKSAGEGPVIYVHPNQVDFGNIYVLKDSSRILNLCNQSFIPAFFQAHMAHKKSLWTIEPNEGMVPPETDVQLALTANLNDT
LTFKDCVILDIENSSTYRIPVQASGTGSTIVSDKPFAPELNLGAHFSLDTHYYHFKLINKGRRIQQLFWMNDSFRPQAKLSKKGRVKKGH
AHVQPQPSGSQEPRDPQSPVFHLHPASMELYPGQAIDVILEGYSATPRIVKEKLVCHAIIGAQKGKSLVMAVNITCEFVAPLIQLSTKQL
IYRLEKKPNSILKPDYQPLAIKNISTLPVNLLLSTSGPFFICETDKSLLPATPEPIKLEIDEEKNLLIKFDPSYRNDLNNWVAEEILAIK

--------------------------------------------------------------
>38138_38138_3_HYDIN-PSMD11_HYDIN_chr16_71052032_ENST00000448089_PSMD11_chr17_30791067_ENST00000261712_length(transcript)=7134nt_BP=3617nt
GGAGCCCCTCAGCGGCGGCGGGGTCTGTGAGTTGGACGCGGGGTCTTGGCGGGGAATGGAGGTAGAATAAACGTGGGACCCGGAGTGCAC
CAAGGTGAGAAAAAAAAATTACTAAAAATGACAAGTAGAAGACTTGAGGAGTCCATGGGGGCTGTTCAGATGGGATTGGTCAATATGTTC
AAAGGATTTCAAAGCAAGGTTTTGCCACCCCTGAGTCCAAAGGTGGTTACAGAAGAAGAAGTAAACCGAATGCTTACACCCTCAGAGTTC
CTGAAGGAAATGTCCCTGACCACCGAGCAGAGACTGGCAAAAACACGTTTGATGTGCCGACCACAGATCATCGAACTCTTAGATATGGGG
GAAACAACACATCAGAAGTTTTCAGGAATTGACCTGGATCAGGCATTATTCCAGCCCTTTCCATCAGAAATTATATTTCAGAACTACACT
CCCTGTGAAGTCTATGAAGTTCCACTGATTTTGAGGAACAATGACAAAATTCCAAGGTTGGTGAAAGTTGTGGAAGAAAGTTCGCCTTAC
TTTAAAGTAATCAGCCCCAAAGATATTGGCCACAAAGTGGCTCCTGGAGTGCCTTCCATATTCCGAATCCTCTTTACTCCAGAGGAGAAC
AAGGATTACGCCCATACGTTGACCTGTGTTACTGAAAGAGAAAAGTTTATTGTACCCATCAAAGCTAGAGGGGCACGAGCCATTCTCGAT
TTTCCTGACAAGCTGAATTTTTCCACTTGTCCTGTCAAATACAGCACCCAGAAGATTCTGCTGGTACGAAACATTGGCAACAAAAATGCT
GTATTTCACATCAAAACTTGTAGGCCTTTCTCTATAGAACCAGCTATTGGAACTCTTAATGTGGGAGAGTCCATGCAACTGGAAGTGGAG
TTTGAGCCACAGAGTGTGGGCGATCACAGTGGAAGACTTATCGTGTGTTATGACACAGGTGAAAAGGTGTTTGTATCTCTCTATGGAGCT
GCCATAGACATGAATATAAGGCTGGATAAGAATTCCTTGACCATCGAGAAAACCTACATATCTCTGGCCAATCAGCGAACTATAACCATT
CACAATCGCAGTAATATCATTGCCCATTTCCTGTGGAAGGTATTTGCTACCCAGCAAGAAGAGGACAGAGAAAAATATAGGGCCTGTGAT
GATCTGATCAAAGAGGAGAAGGATGAGACTGATGAGTTTTTTGAAGAGTGCATTACTGATCCTTTACTCCGAGAACATCTTTCTGTTCTG
TCCCGAACCTTTGCGAATCAGAGGAGGCTGGTGCAGGGAGACAGCAAGCTGTTCTTCAATAACGTTTTCACTGTGGAGCCCCTGGAAGGT
GATGTCTGGCCCAACTCATCAGCTGAAATCACCGTGTACTTTAACCCACTAGAAGCCAAGCTCTATCAACAGACCATTTACTGCGACATT
TTAGGCCGAGAAATCCGTCTGCCCCTCCGAATCAAAGGGGAAGGCATGGGACCTAAGATTCACTTCAACTTTGAATTGCTGGATATTGGG
AAAGTTTTCACTGGATCTGCACATTGTTATGAGGCGATACTGTACAACAAAGGCAGCATCGATGCTCTCTTCAACATGACCCCTCCAACT
TCAGCTTTGGGGGCCTGCTTTGTTTTCAGTCCCAAGGAAGGCATCATTGAACCAAGTGGAGTCCAAGCTATCCAGATCTCCTTCAGCTCT
ACCATCCTGGGAAACTTTGAAGAAGAGTTCCTGGTCAATGTCAATGGGTCACCTGAGCCTGTGAAACTGACCATTAGAGGCTGTGTCATT
GGACCTACCTTCCATTTTAATGTTCCAGCTCTGCACTTTGGTGATGTTTCCTTTGGGTTTCCTCATACCTTGATATGTTCCCTCAATAAT
ACCTCTTTGATCCCCATGACTTACAAACTGCGTATCCCTGGGGATGGCCTTGGCCATAAAAGCATTTCATATTGTGAGCAGCATGTGGAC
TACAAAAGACCATCTTGGACCAAGGAAGAAATATCCTCAATGAAACCAAAAGAATTCACCATCTCTCCTGACTGTGGCACCATTCGCCCC
CAGGGATTTGCTGCTATCAGGGTGACATTATGCTCCAACACTGTGCAGAAATACGAGCTGGCACTCGTGGTGGACGTGGAGGGCATCGGA
GAAGAGGTGCTGGCGCTCTTAATTACAGCAAGGTGTGTTGTACCTGCCCTCCACCTGGTCAATACAGAGGTGGACTTTGGGCACTGCTTC
CTGAAGTACCCGTATGAGAAAACACTCCAGCTTGCCAATCAAGATGACCTCCCAGGATTCTATGAGGTCCAGCCTCAGGTGTGTGAGGAG
GTGCCTACTGTGCTGTTTTCCAGCCCCACCCCCAGCGGGGTCATCTCCCCAAGCAGCACCATCCACATACCACTGGTCCTGGAGACCCAG
GTCACTGGAGAACACAGATCCACGGTTTACATCTCAATCTTTGGGAGCCAGGACCCCCCTTTGGTATGTCACTTAAAGAGCGCTGGAGAA
GGCCCAGTTATCTACGTCCATCCCAATCAAGTGGACTTCGGGAATATCTACGTCCTAAAAGACTCTTCCAGGATTCTCAACCTATGCAAC
CAGTCCTTCATTCCCGCATTTTTCCAGGCACACATGGCACACAAAAAATCCCTTTGGACGATTGAACCCAATGAAGGCATGGTTCCTCCA
GAAACTGATGTTCAACTGGCACTGACCGCCAACCTGAATGACACACTGACATTCAAGGACTGTGTTATTTTGGACATTGAAAATAGCAGT
ACCTATCGGATTCCTGTTCAGGCTTCCGGAACTGGTTCCACTATTGTTTCAGATAAGCCCTTTGCTCCAGAACTCAATTTGGGGGCACAT
TTTAGCCTGGATACCCACTATTACCACTTTAAGTTGATCAACAAGGGACGTCGGATCCAACAGTTGTTCTGGATGAATGATAGCTTCCGA
CCCCAGGCCAAGCTGAGTAAGAAGGGCCGGGTTAAGAAGGGACATGCTCATGTCCAACCCCAGCCCAGTGGCTCTCAGGAGCCCAGGGAT
CCACAGAGCCCCGTGTTTCATCTCCACCCCGCCAGCATGGAGCTGTACCCAGGCCAGGCAATTGATGTGATACTCGAAGGCTATTCTGCT
ACTCCCAGGAAACCTAACAGTATCCTGAAACCTGATTACCAGCCCTTGGCCATAAAGAACATTTCCACCCTGCCCGTGAACTTGTTGCTG
TCAACATCTGGACCCTTCTTTATATGTGAGACTGATAAATCCCTGCTGCCGGCAACTCCTGAGCCTATTAAACTGGAAATTGATGAAGAA
AAAAACCTGCTGATCAAGTTTGACCCTTCCTACAGAAACGATCTGAACAACTGGGTGGCAGAAGAAATTCTAGCAATTAAGTATGTGGAA
CACCCTCAGATAGACAGCCTGGACCTGCGCGGAGAAGTGCATTACCCCAACCTCAGCTTTGAGACAAAGGAGCTGGATTTTGGCTGCATC
CTGAACGATACTGAGCTCATTCGCTACGTTACCATCACCAACTGCAGTCCGTTGGTTGTGAAGTTTCGCTGGTTCTTCTTGGTGAATGAT
GAGGAAAATCAGATAAGGTCGAGCTGTGTTTAGAGTGCATCGAATGGGCCAAGTCAGAGAAAAGAACTTTCTTACGCCAAGCTTTGGAGG
CAAGACTGGTGTCTTTGTACTTTGATACCAAGAGGTACCAGGAAGCATTGCATTTGGGTTCTCAGCTGCTGCGGGAGTTGAAAAAGATGG
ACGACAAAGCTCTTTTGGTGGAAGTACAGCTTTTAGAAAGCAAAACATACCATGCCCTGAGCAACCTGCCGAAAGCCCGAGCTGCCTTAA
CTTCTGCTCGAACCACAGCAAATGCCATCTACTGCCCCCCTAAATTGCAGGCCACCTTGGACATGCAGTCGGGTATTATCCATGCAGCAG
AAGAGAAGGACTGGAAAACTGCGTACTCATACTTCTATGAGGCATTTGAGGGTTATGACTCCATCGACAGCCCCAAGGCCATCACATCTC
TGAAGTACATGTTGCTGTGCAAAATCATGCTCAACACCCCAGAAGATGTCCAGGCTTTGGTGAGCGGGAAGCTTGCACTTCGGTATGCAG
GGAGGCAGACAGAAGCATTAAAATGCGTGGCTCAGGCTAGCAAGAACAGATCACTGGCAGATTTTGAAAAGGCTCTGACAGATTACCGGG
CAGAGCTCCGGGATGACCCAATCATCAGCACACACTTGGCCAAGTTGTATGATAACTTACTAGAACAGAATCTGATCCGAGTCATTGAGC
CTTTTTCCAGAGTACAGATTGAACACATATCTAGTCTCATCAAACTCTCCAAGGCCGACGTGGAAAGGAAATTATCACAGATGATTCTTG
ACAAGAAATTTCATGGGATTTTGGACCAGGGGGAGGGTGTCCTGATTATTTTCGATGAACCCCCAGTAGATAAAACTTACGAAGCTGCTC
TGGAAACAATTCAGAACATGAGCAAAGTAGTGGATTCCCTCTACAACAAAGCCAAGAAACTGACATAGAGTTGGATCTGTAGCGGTCCTT
TGGAGAGTGTGTGTGGCGGGAGAGTGAAACCTTGGGGGAAAATGCTAGGAGATTCTTTTTTCTTTTTGTTCTACTTTTCGCTCGGAAAGT
TTTTAAATCCTCATTTGGTGCATCTGTATTCCAGCCAATAGGTGTGCCAGTTTTCATGTAATCTTTACTGGCCCAACTTGGGAGTGGGGA
AATTGCTTAAAAAAAAAGAAAAAGAAAAAAAAAAAGATTATTCTAAATAAAAGGAAAAAGGCTTACACTACCTAAAGCTGTGCTCTCTGC
CTCCTGGGAGAGGGCCGCAAAGCCAGGCACCCCGCCAACCACTGGGGGTCCTAATCCACCTGCTGGGCATCACCTCTCCTCCTCCTCAGA
ATTGGGTGTTTGCTGACCATCAAAAGCAATGACTTTTTATTCTGTTTGTACTGAACCAAAACAAACAACTGTGTATAGACTGCTGTTTTC
TTTTTTATTTGAAATGAGGCATTTTGGTGTTCTTTCCCCTACCATACGGCCTGTCTGCCCTTCCCTCCCCACATTGGCTCCAGCAGAGTA
GCCGAAGGTCCTGCCGCCGCCGCCACCACCACCACCACTGCAGCAACAACAGCAGCAGCAGCAGCAGCGCCTGCATAGCTCCACTCTGAC
CTGTGAAGGAATGGGGATGAGGCCAGGAGCTAGTGTCTACCACGGCCACACAGGGAGCAGTGTGGGCCCTTAGCCCCCAAGGGGCCTGCT
ATGCATGTGGCTTTTTTTTTTTTTTTAAACACAGTAAACTAGATTAGTCGTCAGTGTTTTAATTGCCCCTCTTCTCCTCTCCTGCATTCC
TCTCCTCTCTTCTTTCCTCTCTGTCCCTTCTCTTTCCCCTCTCAACCAGGAGACCATCATGTCTCTCTGCCTTCCTCCTCTCCCCTCCAG
GGGAGTCAGGCTGTCTGTGAAAGCCATGAGCTTCTCTCCCTCTCCCACTCCTCCTCTCCTACTTTCAGATGGATTTATTCCTTTTTTAAA
CAATGAACATCGGAAATGAGACTGTGGGGTGTGGTTTCTCTCTCTCTTTTTTTTTTAATTTTCTTTGTTGGGTTTTTGAGCAACCTCATG
TCCCCTTCCCAGGGAGCTTTTTAATTTACCTCTTAGAACTCAAGTGGATGGGAAGTAGAGCACTATGTGTCAGTATGCTTTGTTTTCTGA
CACGATTACACAGCGAGGCTTTAATGCCATTTGGGTAGGTGAGCTTCTGCACTTCTGTTGTGCTGAACTGTATTTTCTTCTCTCATCTCC
TCTTTGTCTTTTTCTCTTTTCCTCTCCTTCCTGCCTTCTTCTGCTGGCCTCCTTTTCTCTTTCTTTACCTTCCTTGGATTATCCTTCCAG
GTTTTCATAATAAATTTATATTTTGTAAAAGGATTTTGTTGTACCAGGTTTTGCATCCTCACTGAATCTGACTGGCTTTTATTTTCCTCT
CCAAAATCAGGTTTTTGTTCTCAACATCTTTCCCCATCATGTCTAGTCACTGTTTTGGTTTTGGCACCATCAGTATCAAATGTACAAACG
GTTCTTGCTAACCAACACCAGGTATATCTGATGTTCAGATGAGTTCCAATAAAAATAATTTTTTTTTTTTTCAAAAGGTGTCTTTTTCTT
GAGTGCTGGAGGGCTTCCAAGCAAGTCCAGACAGCTCTGTGTGGCCCCACACTAGTCTAGCTCTCATCTGGCCAAAGCTGTTATCTCATT
TGTGTAATGGGAGTCCTTAAGGTAAATTTGGGGTCCAAACTTGGAGGGCTTTGGGGGCAAGAAAGTTGGTGTGTGAGTTCTGAGGTTGGA
AATGAGTTCAGGTGTCTTCTTCCAGGGCAGCATGGTCCAGTGAGCACATGTAAGTTTGGGCAGTAGATCCTCTGAGCCTACTTTCTCTTC
TACTCAGTGAGGATGCTGCTTCCTTGGCAGGTGATTGTGATGTGAAGCTTAGTAAGTCATAGACGTGCAGGTGTCTGGAGAGTCCTGACA
TGCAGTTGTGGTTTCGTTTCCTTTTGGAATCTTCAAAGGCAGCGATTTTCATATTGCCTCACACCCTGGCGGGGGCGGGGGGCTCTGGGA
CCACTGGGGGACCTGCTAAATCCTCTTCAGTCTGAGCAGTTCAGCCATTGTCAGTTTTAGTATTGTGTCTCTGTATTTCACTTGCAGAAA
GAGCTTTGCTTCTATAAAGGACTTTAAAAAGTACTCCAAAGAGATCTAGTTTTGGAGTAGAGGGGAGATGTTTTCTCAAACTTAGGGCAG
TCCTGAGATGCTCAGGCAGTAGCCCTTTTCTCAGTTCCCTTTGCGGGTCTTGGTCAGATGATGCCCTCTAGACCCGTGCTGTCCAATATG
TAGCCGCTAGCCATGTGCAGCTGTCAGGCCCTTGCAACGTGGCTGGTTCGAGCTGTGATACACTGCAAGTGTAAACACAAACCAGACTTC
GAAGGCTTAGTATGATAACAAAAGAAAAGGAGTGTAAAATATGTCAATAACTTTTTTATATATGTGTTGAAATATTTTGGGTATTGGGTT

>38138_38138_3_HYDIN-PSMD11_HYDIN_chr16_71052032_ENST00000448089_PSMD11_chr17_30791067_ENST00000261712_length(amino acids)=1195AA_BP=
MAGNGGRINVGPGVHQGEKKKLLKMTSRRLEESMGAVQMGLVNMFKGFQSKVLPPLSPKVVTEEEVNRMLTPSEFLKEMSLTTEQRLAKT
RLMCRPQIIELLDMGETTHQKFSGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLILRNNDKIPRLVKVVEESSPYFKVISPKDIGHKVAP
GVPSIFRILFTPEENKDYAHTLTCVTEREKFIVPIKARGARAILDFPDKLNFSTCPVKYSTQKILLVRNIGNKNAVFHIKTCRPFSIEPA
IGTLNVGESMQLEVEFEPQSVGDHSGRLIVCYDTGEKVFVSLYGAAIDMNIRLDKNSLTIEKTYISLANQRTITIHNRSNIIAHFLWKVF
ATQQEEDREKYRACDDLIKEEKDETDEFFEECITDPLLREHLSVLSRTFANQRRLVQGDSKLFFNNVFTVEPLEGDVWPNSSAEITVYFN
PLEAKLYQQTIYCDILGREIRLPLRIKGEGMGPKIHFNFELLDIGKVFTGSAHCYEAILYNKGSIDALFNMTPPTSALGACFVFSPKEGI
IEPSGVQAIQISFSSTILGNFEEEFLVNVNGSPEPVKLTIRGCVIGPTFHFNVPALHFGDVSFGFPHTLICSLNNTSLIPMTYKLRIPGD
GLGHKSISYCEQHVDYKRPSWTKEEISSMKPKEFTISPDCGTIRPQGFAAIRVTLCSNTVQKYELALVVDVEGIGEEVLALLITARCVVP
ALHLVNTEVDFGHCFLKYPYEKTLQLANQDDLPGFYEVQPQVCEEVPTVLFSSPTPSGVISPSSTIHIPLVLETQVTGEHRSTVYISIFG
SQDPPLVCHLKSAGEGPVIYVHPNQVDFGNIYVLKDSSRILNLCNQSFIPAFFQAHMAHKKSLWTIEPNEGMVPPETDVQLALTANLNDT
LTFKDCVILDIENSSTYRIPVQASGTGSTIVSDKPFAPELNLGAHFSLDTHYYHFKLINKGRRIQQLFWMNDSFRPQAKLSKKGRVKKGH
AHVQPQPSGSQEPRDPQSPVFHLHPASMELYPGQAIDVILEGYSATPRKPNSILKPDYQPLAIKNISTLPVNLLLSTSGPFFICETDKSL
LPATPEPIKLEIDEEKNLLIKFDPSYRNDLNNWVAEEILAIKYVEHPQIDSLDLRGEVHYPNLSFETKELDFGCILNDTELIRYVTITNC

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>38138_38138_4_HYDIN-PSMD11_HYDIN_chr16_71052032_ENST00000448089_PSMD11_chr17_30791067_ENST00000457654_length(transcript)=5408nt_BP=3617nt
GGAGCCCCTCAGCGGCGGCGGGGTCTGTGAGTTGGACGCGGGGTCTTGGCGGGGAATGGAGGTAGAATAAACGTGGGACCCGGAGTGCAC
CAAGGTGAGAAAAAAAAATTACTAAAAATGACAAGTAGAAGACTTGAGGAGTCCATGGGGGCTGTTCAGATGGGATTGGTCAATATGTTC
AAAGGATTTCAAAGCAAGGTTTTGCCACCCCTGAGTCCAAAGGTGGTTACAGAAGAAGAAGTAAACCGAATGCTTACACCCTCAGAGTTC
CTGAAGGAAATGTCCCTGACCACCGAGCAGAGACTGGCAAAAACACGTTTGATGTGCCGACCACAGATCATCGAACTCTTAGATATGGGG
GAAACAACACATCAGAAGTTTTCAGGAATTGACCTGGATCAGGCATTATTCCAGCCCTTTCCATCAGAAATTATATTTCAGAACTACACT
CCCTGTGAAGTCTATGAAGTTCCACTGATTTTGAGGAACAATGACAAAATTCCAAGGTTGGTGAAAGTTGTGGAAGAAAGTTCGCCTTAC
TTTAAAGTAATCAGCCCCAAAGATATTGGCCACAAAGTGGCTCCTGGAGTGCCTTCCATATTCCGAATCCTCTTTACTCCAGAGGAGAAC
AAGGATTACGCCCATACGTTGACCTGTGTTACTGAAAGAGAAAAGTTTATTGTACCCATCAAAGCTAGAGGGGCACGAGCCATTCTCGAT
TTTCCTGACAAGCTGAATTTTTCCACTTGTCCTGTCAAATACAGCACCCAGAAGATTCTGCTGGTACGAAACATTGGCAACAAAAATGCT
GTATTTCACATCAAAACTTGTAGGCCTTTCTCTATAGAACCAGCTATTGGAACTCTTAATGTGGGAGAGTCCATGCAACTGGAAGTGGAG
TTTGAGCCACAGAGTGTGGGCGATCACAGTGGAAGACTTATCGTGTGTTATGACACAGGTGAAAAGGTGTTTGTATCTCTCTATGGAGCT
GCCATAGACATGAATATAAGGCTGGATAAGAATTCCTTGACCATCGAGAAAACCTACATATCTCTGGCCAATCAGCGAACTATAACCATT
CACAATCGCAGTAATATCATTGCCCATTTCCTGTGGAAGGTATTTGCTACCCAGCAAGAAGAGGACAGAGAAAAATATAGGGCCTGTGAT
GATCTGATCAAAGAGGAGAAGGATGAGACTGATGAGTTTTTTGAAGAGTGCATTACTGATCCTTTACTCCGAGAACATCTTTCTGTTCTG
TCCCGAACCTTTGCGAATCAGAGGAGGCTGGTGCAGGGAGACAGCAAGCTGTTCTTCAATAACGTTTTCACTGTGGAGCCCCTGGAAGGT
GATGTCTGGCCCAACTCATCAGCTGAAATCACCGTGTACTTTAACCCACTAGAAGCCAAGCTCTATCAACAGACCATTTACTGCGACATT
TTAGGCCGAGAAATCCGTCTGCCCCTCCGAATCAAAGGGGAAGGCATGGGACCTAAGATTCACTTCAACTTTGAATTGCTGGATATTGGG
AAAGTTTTCACTGGATCTGCACATTGTTATGAGGCGATACTGTACAACAAAGGCAGCATCGATGCTCTCTTCAACATGACCCCTCCAACT
TCAGCTTTGGGGGCCTGCTTTGTTTTCAGTCCCAAGGAAGGCATCATTGAACCAAGTGGAGTCCAAGCTATCCAGATCTCCTTCAGCTCT
ACCATCCTGGGAAACTTTGAAGAAGAGTTCCTGGTCAATGTCAATGGGTCACCTGAGCCTGTGAAACTGACCATTAGAGGCTGTGTCATT
GGACCTACCTTCCATTTTAATGTTCCAGCTCTGCACTTTGGTGATGTTTCCTTTGGGTTTCCTCATACCTTGATATGTTCCCTCAATAAT
ACCTCTTTGATCCCCATGACTTACAAACTGCGTATCCCTGGGGATGGCCTTGGCCATAAAAGCATTTCATATTGTGAGCAGCATGTGGAC
TACAAAAGACCATCTTGGACCAAGGAAGAAATATCCTCAATGAAACCAAAAGAATTCACCATCTCTCCTGACTGTGGCACCATTCGCCCC
CAGGGATTTGCTGCTATCAGGGTGACATTATGCTCCAACACTGTGCAGAAATACGAGCTGGCACTCGTGGTGGACGTGGAGGGCATCGGA
GAAGAGGTGCTGGCGCTCTTAATTACAGCAAGGTGTGTTGTACCTGCCCTCCACCTGGTCAATACAGAGGTGGACTTTGGGCACTGCTTC
CTGAAGTACCCGTATGAGAAAACACTCCAGCTTGCCAATCAAGATGACCTCCCAGGATTCTATGAGGTCCAGCCTCAGGTGTGTGAGGAG
GTGCCTACTGTGCTGTTTTCCAGCCCCACCCCCAGCGGGGTCATCTCCCCAAGCAGCACCATCCACATACCACTGGTCCTGGAGACCCAG
GTCACTGGAGAACACAGATCCACGGTTTACATCTCAATCTTTGGGAGCCAGGACCCCCCTTTGGTATGTCACTTAAAGAGCGCTGGAGAA
GGCCCAGTTATCTACGTCCATCCCAATCAAGTGGACTTCGGGAATATCTACGTCCTAAAAGACTCTTCCAGGATTCTCAACCTATGCAAC
CAGTCCTTCATTCCCGCATTTTTCCAGGCACACATGGCACACAAAAAATCCCTTTGGACGATTGAACCCAATGAAGGCATGGTTCCTCCA
GAAACTGATGTTCAACTGGCACTGACCGCCAACCTGAATGACACACTGACATTCAAGGACTGTGTTATTTTGGACATTGAAAATAGCAGT
ACCTATCGGATTCCTGTTCAGGCTTCCGGAACTGGTTCCACTATTGTTTCAGATAAGCCCTTTGCTCCAGAACTCAATTTGGGGGCACAT
TTTAGCCTGGATACCCACTATTACCACTTTAAGTTGATCAACAAGGGACGTCGGATCCAACAGTTGTTCTGGATGAATGATAGCTTCCGA
CCCCAGGCCAAGCTGAGTAAGAAGGGCCGGGTTAAGAAGGGACATGCTCATGTCCAACCCCAGCCCAGTGGCTCTCAGGAGCCCAGGGAT
CCACAGAGCCCCGTGTTTCATCTCCACCCCGCCAGCATGGAGCTGTACCCAGGCCAGGCAATTGATGTGATACTCGAAGGCTATTCTGCT
ACTCCCAGGAAACCTAACAGTATCCTGAAACCTGATTACCAGCCCTTGGCCATAAAGAACATTTCCACCCTGCCCGTGAACTTGTTGCTG
TCAACATCTGGACCCTTCTTTATATGTGAGACTGATAAATCCCTGCTGCCGGCAACTCCTGAGCCTATTAAACTGGAAATTGATGAAGAA
AAAAACCTGCTGATCAAGTTTGACCCTTCCTACAGAAACGATCTGAACAACTGGGTGGCAGAAGAAATTCTAGCAATTAAGTATGTGGAA
CACCCTCAGATAGACAGCCTGGACCTGCGCGGAGAAGTGCATTACCCCAACCTCAGCTTTGAGACAAAGGAGCTGGATTTTGGCTGCATC
CTGAACGATACTGAGCTCATTCGCTACGTTACCATCACCAACTGCAGTCCGTTGGTTGTGAAGTTTCGCTGGTTCTTCTTGGTGAATGAT
GAGGAAAATCAGATAAGGTCGAGCTGTGTTTAGAGTGCATCGAATGGGCCAAGTCAGAGAAAAGAACTTTCTTACGCCAAGCTTTGGAGG
CAAGACTGGTGTCTTTGTACTTTGATACCAAGAGGTACCAGGAAGCATTGCATTTGGGTTCTCAGCTGCTGCGGGAGTTGAAAAAGATGG
ACGACAAAGCTCTTTTGGTGGAAGTACAGCTTTTAGAAAGCAAAACATACCATGCCCTGAGCAACCTGCCGAAAGCCCGAGCTGCCTTAA
CTTCTGCTCGAACCACAGCAAATGCCATCTACTGCCCCCCTAAATTGCAGGCCACCTTGGACATGCAGTCGGGTATTATCCATGCAGCAG
AAGAGAAGGACTGGAAAACTGCGTACTCATACTTCTATGAGGCATTTGAGGGTTATGACTCCATCGACAGCCCCAAGGCCATCACATCTC
TGAAGTACATGTTGCTGTGCAAAATCATGCTCAACACCCCAGAAGATGTCCAGGCTTTGGTGAGCGGGAAGCTTGCACTTCGGTATGCAG
GGAGGCAGACAGAAGCATTAAAATGCGTGGCTCAGGCTAGCAAGAACAGATCACTGGCAGATTTTGAAAAGGCTCTGACAGATTACCGGG
CAGAGCTCCGGGATGACCCAATCATCAGCACACACTTGGCCAAGTTGTATGATAACTTACTAGAACAGAATCTGATCCGAGTCATTGAGC
CTTTTTCCAGAGTACAGATTGAACACATATCTAGTCTCATCAAACTCTCCAAGGCCGACGTGGAAAGGAAATTATCACAGATGATTCTTG
ACAAGAAATTTCATGGGATTTTGGACCAGGGGGAGGGTGTCCTGATTATTTTCGATGAACCCCCAGTAGATAAAACTTACGAAGCTGCTC
TGGAAACAATTCAGAACATGAGCAAAGTAGTGGATTCCCTCTACAACAAAGCCAAGAAACTGACATAGGTGAGTGCTGGCTTCAGGACCC
CAGGGCTGGGCAGCTCTGTCTTCTGCGTGTCGAGACTGAAAACCTCCTCCTGGTGTCCTCATGGCTTCCTGATTGACACTGCTCTGTCTT
CTCTTGCAGAGTTGGATCTGTAGCGGTCCTTTGGAGAGTGTGTGTGGCGGGAGAGTGAAACCTTGGGGGAAAATGCTAGGAGATTCTTTT
TTCTTTTTGTTCTACTTTTCGCTCGGAAAGTTTTTAAATCCTCATTTGGTGCATCTGTATTCCAGCCAATAGGTGTGCCAGTTTTCATGT
AATCTTTACTGGCCCAACTTGGGAGTGGGGAAATTGCTTAAAAAAAAAGAAAAAGAAAAAAAAAAAGATTATTCTAAATAAAAGGAAAAA
GGCTTACACTACCTAAAGCTGTGCTCTCTGCCTCCTGGGAGAGGGCCGCAAAGCCAGGCACCCCGCCAACCACTGGGGGTCCTAATCCAC
CTGCTGGGCATCACCTCTCCTCCTCCTCAGAATTGGGTGTTTGCTGACCATCAAAAGCAATGACTTTTTATTCTGTTTGTACTGAACCAA
AACAAACAACTGTGTATAGACTGCTGTTTTCTTTTTTATTTGAAATGAGGCATTTTGGTGTTCTTTCCCCTACCATACGGCCTGTCTGCC
CTTCCCTCCCCACATTGGCTCCAGCAGAGTAGCCGAAGGTCCTGCCGCCGCCGCCACCACCACCACCACTGCAGCAACAACAGCAGCAGC
AGCAGCAGCGCCTGCATAGCTCCACTCTGACCTGTGAAGGAATGGGGATGAGGCCAGGAGCTAGTGTCTACCACGGCCACACAGGGAGCA

>38138_38138_4_HYDIN-PSMD11_HYDIN_chr16_71052032_ENST00000448089_PSMD11_chr17_30791067_ENST00000457654_length(amino acids)=1195AA_BP=
MAGNGGRINVGPGVHQGEKKKLLKMTSRRLEESMGAVQMGLVNMFKGFQSKVLPPLSPKVVTEEEVNRMLTPSEFLKEMSLTTEQRLAKT
RLMCRPQIIELLDMGETTHQKFSGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLILRNNDKIPRLVKVVEESSPYFKVISPKDIGHKVAP
GVPSIFRILFTPEENKDYAHTLTCVTEREKFIVPIKARGARAILDFPDKLNFSTCPVKYSTQKILLVRNIGNKNAVFHIKTCRPFSIEPA
IGTLNVGESMQLEVEFEPQSVGDHSGRLIVCYDTGEKVFVSLYGAAIDMNIRLDKNSLTIEKTYISLANQRTITIHNRSNIIAHFLWKVF
ATQQEEDREKYRACDDLIKEEKDETDEFFEECITDPLLREHLSVLSRTFANQRRLVQGDSKLFFNNVFTVEPLEGDVWPNSSAEITVYFN
PLEAKLYQQTIYCDILGREIRLPLRIKGEGMGPKIHFNFELLDIGKVFTGSAHCYEAILYNKGSIDALFNMTPPTSALGACFVFSPKEGI
IEPSGVQAIQISFSSTILGNFEEEFLVNVNGSPEPVKLTIRGCVIGPTFHFNVPALHFGDVSFGFPHTLICSLNNTSLIPMTYKLRIPGD
GLGHKSISYCEQHVDYKRPSWTKEEISSMKPKEFTISPDCGTIRPQGFAAIRVTLCSNTVQKYELALVVDVEGIGEEVLALLITARCVVP
ALHLVNTEVDFGHCFLKYPYEKTLQLANQDDLPGFYEVQPQVCEEVPTVLFSSPTPSGVISPSSTIHIPLVLETQVTGEHRSTVYISIFG
SQDPPLVCHLKSAGEGPVIYVHPNQVDFGNIYVLKDSSRILNLCNQSFIPAFFQAHMAHKKSLWTIEPNEGMVPPETDVQLALTANLNDT
LTFKDCVILDIENSSTYRIPVQASGTGSTIVSDKPFAPELNLGAHFSLDTHYYHFKLINKGRRIQQLFWMNDSFRPQAKLSKKGRVKKGH
AHVQPQPSGSQEPRDPQSPVFHLHPASMELYPGQAIDVILEGYSATPRKPNSILKPDYQPLAIKNISTLPVNLLLSTSGPFFICETDKSL
LPATPEPIKLEIDEEKNLLIKFDPSYRNDLNNWVAEEILAIKYVEHPQIDSLDLRGEVHYPNLSFETKELDFGCILNDTELIRYVTITNC

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Fusion Gene PPI Analysis for HYDIN-PSMD11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HYDIN-PSMD11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HYDIN-PSMD11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource