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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HYOU1-SZRD1 (FusionGDB2 ID:38151)

Fusion Gene Summary for HYOU1-SZRD1

Fusion gene summary

Fusion gene information	Fusion gene name: HYOU1-SZRD1
	Fusion gene ID: 38151
		Hgene	Tgene
	Gene symbol	HYOU1	SZRD1
	Gene ID	10525	26099
	Gene name	hypoxia up-regulated 1	SUZ RNA binding domain containing 1
	Synonyms	GRP-170\|Grp170\|HSP12A\|IMD59\|ORP-150\|ORP150	C1orf144
	Cytomap	11q23.3	1p36.13
	Type of gene	protein-coding	protein-coding
	Description	hypoxia up-regulated protein 1150 kDa oxygen-regulated protein170 kDa glucose-regulated proteinepididymis secretory sperm binding proteinoxygen regulated protein (150kD)	SUZ domain-containing protein 1UPF0485 protein C1orf144putative MAPK activating protein PM20,PM21putative MAPK-activating protein PM18/PM20/PM22
	Modification date	20200313	20200313
	UniProtAcc	Q9Y4L1	.
	Ensembl transtripts involved in fusion gene	ENST00000404233, ENST00000525859, ENST00000529972, ENST00000543287,	ENST00000472461, ENST00000375590, ENST00000401089, ENST00000492354, ENST00000401088, ENST00000471507,
Fusion gene scores	* DoF score	9 X 11 X 4=396	5 X 4 X 3=60
	# samples	12	5
	** MAII score	log2(12/396*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HYOU1 [Title/Abstract] AND SZRD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HYOU1(118922150)-SZRD1(16717870), # samples:1
Anticipated loss of major functional domain due to fusion event.	HYOU1-SZRD1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HYOU1	GO:0006888	ER to Golgi vesicle-mediated transport	10837345
Hgene	HYOU1	GO:0071456	cellular response to hypoxia	10837345
Hgene	HYOU1	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	10037731

Fusion gene breakpoints across HYOU1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SZRD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	TGCT	TCGA-2G-AALN-01A	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+

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Fusion Gene ORF analysis for HYOU1-SZRD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000404233	ENST00000472461	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-3UTR	ENST00000525859	ENST00000472461	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-3UTR	ENST00000529972	ENST00000472461	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-3UTR	ENST00000543287	ENST00000472461	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-intron	ENST00000404233	ENST00000375590	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-intron	ENST00000404233	ENST00000401089	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-intron	ENST00000404233	ENST00000492354	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-intron	ENST00000525859	ENST00000375590	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-intron	ENST00000525859	ENST00000401089	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-intron	ENST00000525859	ENST00000492354	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-intron	ENST00000529972	ENST00000375590	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-intron	ENST00000529972	ENST00000401089	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-intron	ENST00000529972	ENST00000492354	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-intron	ENST00000543287	ENST00000375590	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-intron	ENST00000543287	ENST00000401089	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
5CDS-intron	ENST00000543287	ENST00000492354	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
Frame-shift	ENST00000525859	ENST00000401088	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
Frame-shift	ENST00000525859	ENST00000471507	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
Frame-shift	ENST00000543287	ENST00000401088	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
Frame-shift	ENST00000543287	ENST00000471507	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
In-frame	ENST00000404233	ENST00000401088	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
In-frame	ENST00000404233	ENST00000471507	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
In-frame	ENST00000529972	ENST00000401088	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+
In-frame	ENST00000529972	ENST00000471507	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000404233	HYOU1	chr11	118922150	-	ENST00000401088	SZRD1	chr1	16717870	+	5061	1651	80	1657	525
ENST00000404233	HYOU1	chr11	118922150	-	ENST00000471507	SZRD1	chr1	16717870	+	2322	1651	80	1657	525
ENST00000529972	HYOU1	chr11	118922150	-	ENST00000401088	SZRD1	chr1	16717870	+	5081	1671	100	1677	525
ENST00000529972	HYOU1	chr11	118922150	-	ENST00000471507	SZRD1	chr1	16717870	+	2342	1671	100	1677	525

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000404233	ENST00000401088	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+	0.001214007	0.99878603
ENST00000404233	ENST00000471507	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+	0.003032895	0.99696714
ENST00000529972	ENST00000401088	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+	0.001172024	0.998828
ENST00000529972	ENST00000471507	HYOU1	chr11	118922150	-	SZRD1	chr1	16717870	+	0.002763016	0.99723697

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Fusion Genomic Features for HYOU1-SZRD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HYOU1	chr11	118922149	-	SZRD1	chr1	16717869	+	3.46E-06	0.99999654
HYOU1	chr11	118922149	-	SZRD1	chr1	16717869	+	3.46E-06	0.99999654

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HYOU1-SZRD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:118922150/chr1:16717870)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HYOU1 Q9Y4L1	.
FUNCTION: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. {ECO:0000269\|PubMed:10037731}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SZRD1

chr11:118922150

chr1:16717870

ENST00000401088

111_152

153.0

Domain

SUZ-C

Tgene

SZRD1

chr11:118922150

chr1:16717870

ENST00000401088

42_107

153.0

Domain

SUZ

Tgene

SZRD1

chr11:118922150

chr1:16717870

ENST00000401089

111_152

134.0

Domain

SUZ-C

Tgene

SZRD1

chr11:118922150

chr1:16717870

ENST00000401089

42_107

134.0

Domain

SUZ

Tgene

SZRD1

chr11:118922150

chr1:16717870

ENST00000492354

111_152

133.0

Domain

SUZ-C

Tgene

SZRD1

chr11:118922150

chr1:16717870

ENST00000492354

42_107

133.0

Domain

SUZ

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HYOU1

chr11:118922150

chr1:16717870

ENST00000404233

603_606

508

1000.0

Compositional bias

Note=Poly-Glu

Hgene

HYOU1

chr11:118922150

chr1:16717870

ENST00000404233

636_641

508

1000.0

Compositional bias

Note=Poly-Pro

Hgene

HYOU1

chr11:118922150

chr1:16717870

ENST00000404233

996_999

508

1000.0

Motif

Prevents secretion from ER

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Fusion Gene Sequence for HYOU1-SZRD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>38151_38151_1_HYOU1-SZRD1_HYOU1_chr11_118922150_ENST00000404233_SZRD1_chr1_16717870_ENST00000401088_length(transcript)=5061nt_BP=1651nt
AACAGTTTGCAAACCGAGAGGAGTTGTGAAGGGCGCGGGTGGGGGGCGCTGCCGGCCTCGTGGGTACGTTCGTGCCGCGTCTGTCCCAGA
GCTGGGGCCGCAGGAGCGGAGGCAAGAGGGGCACTATGGCAGACAAAGTTAGGAGGCAGAGGCCGAGGAGGCGAGTCTGTTGGGCCTTGG
TGGCTGTGCTCTTGGCAGACCTGTTGGCACTGAGTGATACACTGGCAGTGATGTCTGTGGACCTGGGCAGTGAGTCCATGAAGGTGGCCA
TTGTCAAACCTGGAGTGCCCATGGAAATTGTCTTGAATAAGGAATCTCGGAGGAAAACACCGGTGATCGTGACCCTGAAAGAAAATGAAA
GATTCTTTGGAGACAGTGCAGCAAGCATGGCGATTAAGAATCCAAAGGCTACGCTACGTTACTTCCAGCACCTCCTGGGGAAGCAGGCAG
ATAACCCCCATGTAGCTCTTTACCAGGCCCGCTTCCCGGAGCACGAGCTGACTTTCGACCCACAGAGGCAGACTGTGCACTTTCAGATCA
GCTCGCAGCTGCAGTTCTCACCTGAGGAAGTGTTGGGCATGGTTCTCAATTATTCTCGTTCTCTAGCTGAAGATTTTGCAGAGCAGCCCA
TCAAGGATGCAGTGATCACCGTGCCAGTCTTCTTCAACCAGGCCGAGCGCCGAGCTGTGCTGCAGGCTGCTCGTATGGCTGGCCTCAAAG
TGCTGCAGCTCATCAATGACAACACCGCCACTGCCCTCAGCTATGGTGTCTTCCGCCGGAAAGATATTAACACCACTGCCCAGAATATCA
TGTTCTATGACATGGGCTCAGGCAGCACCGTATGCACCATTGTGACCTACCAGATGGTGAAGACTAAGGAAGCTGGGATGCAGCCACAGC
TGCAGATCCGGGGAGTAGGATTTGACCGTACCCTGGGGGGCCTGGAGATGGAGCTCCGGCTTCGAGAACGCCTGGCTGGGCTTTTCAATG
AGCAGCGCAAGGGTCAGAGAGCAAAGGATGTGCGGGAGAACCCGCGTGCCATGGCCAAGCTGCTGCGTGAGGCTAATCGGCTCAAAACCG
TCCTCAGTGCCAACGCTGACCACATGGCACAGATTGAAGGCCTGATGGATGATGTGGACTTCAAGGCAAAAGTGACTCGTGTGGAATTTG
AGGAGTTGTGTGCAGACTTGTTTGAGCGGGTGCCTGGGCCTGTACAGCAGGCCCTCCAGAGTGCCGAAATGAGTCTGGATGAGATTGAGC
AGGTGATCCTGGTGGGTGGGGCCACTCGGGTCCCCAGAGTTCAGGAGGTGCTGCTGAAGGCCGTGGGCAAGGAGGAGCTGGGGAAGAACA
TCAATGCAGATGAAGCAGCCGCCATGGGGGCAGTGTACCAGGCAGCTGCGCTCAGCAAAGCCTTTAAAGTGAAGCCATTTGTCGTCCGAG
ATGCAGTGGTCTACCCCATCCTGGTGGAGTTCACGAGGGAGGTGGAGGAGGAGCCTGGGATTCACAGCCTGAAGCACAATAAACGGGTAC
TCTTCTCTCGGATGGGGCCCTACCCTCAACGCAAAGTCATCACCTTTAACCGCTACAGCCATGATTTCAACTTCCACATCAACTACGGCG
ACCTGGGCTTCCTGGGGCCTGAAGATCTTCGGAAATAGACAGACGGTTGGAAAAAAAACTGAAGATCACACAAAAAGAGAGCAGGAAATC
CAAATCTCCTCCCAAAGTGCCCATTGTGATTCAGGACGATAGCCTTCCCGCGGGGCCCCCTCCACAGATCCGCATCCTCAAGAGGCCCAC
CAGCAACGGTGTGGTCAGCAGCCCCAACTCCACCAGCAGGCCCACCCTTCCAGTCAAGTCCCTAGCACAGCGAGAGGCCGAGTACGCCGA
GGCCCGGAAGCGGATCCTGGGCAGCGCCAGCCCCGAGGAGGAGCAGGAGAAACCCATCCTCGACAGGCCAACCAGGATCTCCCAACCCGA
AGACAGCAGGCAGCCCAATAATGTGATCAGACAGCCTTTGGGTCCTGATGGGTCTCAAGGCTTCAAACAGCGCAGATAAATGCAGGCAAG
AAAAGATGCCGCCGTTGCTGCCGTCACCGCCTCCTGGGTCGTCCGCCACGGGTTGCACTGCCGTGGCAGACAGCTGGACTTGAGCAGAGG
GAACGACCTGACTTACTTGCACTGTGATCCCCCTTGCTCCGCCCACTGTGACCTTGAACCCCATGCACTGTGACCTCCCCCCTTCTCCCC
CTTCCCACTGTGATTGGCACATCGACAAGGGCTGTCCCAAGTCAATGGAAAGGGAAAGGGTGGGGGTTAGGGGAAGGTTGGGGGGACCCA
GCAAGGACTCAGAGAGTCAGACAGTGCCACTTGGCCACTTGGGGTAAAGCCAGTGCCAGCAATAACAGTTTATCATGCTCATTAATTTGG
GATTTCAAAACACAAATGAAAACTCACACCCACCCACCCCCAAGTGCATGTCTCCATCACTTAAAAAGTAAGTTCCATTTGAAAATATCC
TTTCTTTTTTTTTTCTTCCTATTTTTGTTTGTTTATACAAATATCTGATTTGCAAGAAAAAGTGCATGGGAGGGGTTTTAGTGGTTTAAT
GAATTTTTAATTAAGAAAGGGTAGTTTGGTAGTCTACTTAAAAATGTTTCTGGGAAATTCACTAGAAACATTAACCAATAGGATTTTGGT
GAGCTTAGCTTCTGTATTCCTACTGCCGCCCAGAAAAGGGGCAGGGCTCTGCAGCCGCCAGGACAGACGAGCACCCCATGCCTATACCTC
CCTCCCCGAGCTAAGTCCCAGGGCATCTGGGCCTTGCCTGGAGACTGGGCTAGCTCTGTAGGCTCGGAGAGCCTGGGGAGGGTGCCAACC
CCACCTCTAGTATTTTGGGAGATAGGGAAAGTGAACCGACTTCCCCTTCCCATACCCCTCAGGGTGGTTCCCTACCAGCCAGGCTTACTA
CTTCTAGAAGAAAGCAGAGTGCCAGGGAGTGAGATTGCATCCCTGGGCTTAGAAGTGACGGAGAGAAGACTTGTTTAGTATTTTGCCATC
AGCACAAGGAAAACCAGGAGAGAGTCTGCCTCCAGGACTCTGAGCCTTCTGCCTCGTATGTTCAGAAGGTGGATAGGTCTTCCCACTCCA
GCATGGCTTGAACTCTTAGGGGTCTGCAGTGCTCCATCTCCATTGGTGGCCCCAGCTCAGTAACTATACCTGGTACATTTCCTGTGTGCA
ATCAGTACCTTGAAGGCAGAACATTCTGAATAAAGTTGGAAAAAGAACAGCTTTGCTTTGCAAAGATTGATGACAGACTGGTTCCTCAGA
GGCCTAGGCTACCCGTCACCCCTTTTTCCAGAGCGAGGGCCTGGAATGAAGGCAGTTTATCCTCTGTCCCTGGAGCCTGGGGTTTGCTTT
GGCTCCTTGAGGTGGAAGAGACTAAGAGGGCAGCTGCCCAGAGCAGCTGTGTGTACCTGGCTCCTCTCAGGCTTCCTGATCCCTTCCGTT
GCACTGCGCCTTATCCCTCAGCCAGCCAGACAGCCTCCCTGCTCCTGACCAGCAGATACGTTTCGGAGTGGTTGGTGTGGTTTTTGTGAT
GAGGGCAGCACGTGGTGGCCAAGGTGGCAAGCTGAGTCTCACAGGCTCACTCCCTCGTTGGTTCCCTGTGGGAATGGTAGGCCAGGCCCA
GTAAGCCATGCCCCAACACGTCCTCTCCTCCGGAGGAAGGGCCAGCTGCCAGCTGAGTCAGCAGCTAGTCCATAGCACAGCCTTATAACT
GTAAAGCCAGGCATTGCCCATGAGCAGAGCTGGAACCAGAGCTTCAGTCAGTAAGAGGGAGGATTACCTTCAGGAGAAGGCAAGGAAGAA
AACTGGCTGCTATCTTTATAGTTCCACTGCCCTAACCAAGTGTCCACATTCTAAATGTGTAGTGTCCATCCCTTATGTAATAGTGGTTTC
CCGCCCAAAGTGAGACTTTCCTTTTAATTGGAGAAGGGTATAGAGGTAGTCCAGGTGGGAACGCCAGAAGTGCTGATTGCCCAGCCATTG
GGACCACCTGTTCTTGCCCCACTACCCTCTAGTGGGAGGCCAAAGTAAAGGCTGGCTGGTGGGTGTCTGTGGATTGAGGATGTGGCAGGG
ACTGGTCCTCCCACCTCCCTCTGGCCAAAGATGGGCTTTGCCCGCTGTGTGCCTGTCACCACCCACCAGCAGTCATGCCCTGGGCTTCCC
AAATGGAGAGGTAGCAGGCAACGTTTTTAAAAAGAAAGAAAACAGGAAACTGTATTGTGTCGGGGGAGGCGGGAGGGAGATGAGGAAACG
GTTTGGATTTTGTGTGTGGGAGGGTATTTTTTGGGGGTAGTTGTCTGTAACTTTCCTAAGTGCTTTTTTTCCTTTTCTTTTTTAAAGTAA
GTTGCAGGCTTTGGCTTGGAAAACCCCAGGGGGATGGGGGGCAGAAACCTGAGGCTGCTGCCCCTTTATCTGCCTTCACGGTACTGTCCC
CTTCCCCCAGCTCCTCCCTGACCCCATGGGCCAGGCCTCAGACCTTCCAGCTAACCGCTTCCCATGAGCCACTACTCTGATGTCAGCCTA
TAACCAAAGGAGCTGGGGGGTCCAGGCCTGGTGACCAACCTTTCTCAGCCCACTCAATCAGGGTGCTCCCCACCTGCAGGCAGGAGGCAA
CACCCTATCTGCTACCATCAGCCCCTTCCAGAGCCCATCTGCCCCGCCCAGCCCTGCCCTGCCCAGCCATACCCTGCTCTGCCCCATCTG
GGGGTGCCCTGCTCAGGGATGGGCTGGCAGGGCTGTACCCAGCCTCCCTGGTAAGCAGAGACTCAAGAAACCTCTGGGGTCCTGTTTTCT
GGTCGTGTGATCCCAGGGGTGCACATGGGCCCCTTGGGTGTCTGAACAGAAGGGCATGGGAGGGAGGGCTGCACCCCTGCAGTCTTACTC
TGCTGGTGTAGCGGGCAGCTGCCCACTCCCACCCCACCCTGCACCGCGGGCTCCTGAGTCGGCAGATTAAGCATTTTATAAATTGTATTT

>38151_38151_1_HYOU1-SZRD1_HYOU1_chr11_118922150_ENST00000404233_SZRD1_chr1_16717870_ENST00000401088_length(amino acids)=525AA_BP=
MSQSWGRRSGGKRGTMADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLK
ENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFA
EQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGM
QPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTR
VEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPF

--------------------------------------------------------------
>38151_38151_2_HYOU1-SZRD1_HYOU1_chr11_118922150_ENST00000404233_SZRD1_chr1_16717870_ENST00000471507_length(transcript)=2322nt_BP=1651nt
AACAGTTTGCAAACCGAGAGGAGTTGTGAAGGGCGCGGGTGGGGGGCGCTGCCGGCCTCGTGGGTACGTTCGTGCCGCGTCTGTCCCAGA
GCTGGGGCCGCAGGAGCGGAGGCAAGAGGGGCACTATGGCAGACAAAGTTAGGAGGCAGAGGCCGAGGAGGCGAGTCTGTTGGGCCTTGG
TGGCTGTGCTCTTGGCAGACCTGTTGGCACTGAGTGATACACTGGCAGTGATGTCTGTGGACCTGGGCAGTGAGTCCATGAAGGTGGCCA
TTGTCAAACCTGGAGTGCCCATGGAAATTGTCTTGAATAAGGAATCTCGGAGGAAAACACCGGTGATCGTGACCCTGAAAGAAAATGAAA
GATTCTTTGGAGACAGTGCAGCAAGCATGGCGATTAAGAATCCAAAGGCTACGCTACGTTACTTCCAGCACCTCCTGGGGAAGCAGGCAG
ATAACCCCCATGTAGCTCTTTACCAGGCCCGCTTCCCGGAGCACGAGCTGACTTTCGACCCACAGAGGCAGACTGTGCACTTTCAGATCA
GCTCGCAGCTGCAGTTCTCACCTGAGGAAGTGTTGGGCATGGTTCTCAATTATTCTCGTTCTCTAGCTGAAGATTTTGCAGAGCAGCCCA
TCAAGGATGCAGTGATCACCGTGCCAGTCTTCTTCAACCAGGCCGAGCGCCGAGCTGTGCTGCAGGCTGCTCGTATGGCTGGCCTCAAAG
TGCTGCAGCTCATCAATGACAACACCGCCACTGCCCTCAGCTATGGTGTCTTCCGCCGGAAAGATATTAACACCACTGCCCAGAATATCA
TGTTCTATGACATGGGCTCAGGCAGCACCGTATGCACCATTGTGACCTACCAGATGGTGAAGACTAAGGAAGCTGGGATGCAGCCACAGC
TGCAGATCCGGGGAGTAGGATTTGACCGTACCCTGGGGGGCCTGGAGATGGAGCTCCGGCTTCGAGAACGCCTGGCTGGGCTTTTCAATG
AGCAGCGCAAGGGTCAGAGAGCAAAGGATGTGCGGGAGAACCCGCGTGCCATGGCCAAGCTGCTGCGTGAGGCTAATCGGCTCAAAACCG
TCCTCAGTGCCAACGCTGACCACATGGCACAGATTGAAGGCCTGATGGATGATGTGGACTTCAAGGCAAAAGTGACTCGTGTGGAATTTG
AGGAGTTGTGTGCAGACTTGTTTGAGCGGGTGCCTGGGCCTGTACAGCAGGCCCTCCAGAGTGCCGAAATGAGTCTGGATGAGATTGAGC
AGGTGATCCTGGTGGGTGGGGCCACTCGGGTCCCCAGAGTTCAGGAGGTGCTGCTGAAGGCCGTGGGCAAGGAGGAGCTGGGGAAGAACA
TCAATGCAGATGAAGCAGCCGCCATGGGGGCAGTGTACCAGGCAGCTGCGCTCAGCAAAGCCTTTAAAGTGAAGCCATTTGTCGTCCGAG
ATGCAGTGGTCTACCCCATCCTGGTGGAGTTCACGAGGGAGGTGGAGGAGGAGCCTGGGATTCACAGCCTGAAGCACAATAAACGGGTAC
TCTTCTCTCGGATGGGGCCCTACCCTCAACGCAAAGTCATCACCTTTAACCGCTACAGCCATGATTTCAACTTCCACATCAACTACGGCG
ACCTGGGCTTCCTGGGGCCTGAAGATCTTCGGAAATAGACAGACGGTTGGAAAAAAAACTGAAGATCACACAAAAAGAGAGGAAATCCAA
ATCTCCTCCCAAAGTGCCCATTGTGATTCAGGACGATAGCCTTCCCGCGGGGCCCCCTCCACAGATCCGCATCCTCAAGAGGCCCACCAG
CAACGGTGTGGTCAGCAGCCCCAACTCCACCAGCAGGCCCACCCTTCCAGTCAAGTCCCTAGCACAGCGAGAGGCCGAGTACGCCGAGGC
CCGGAAGCGGATCCTGGGCAGCGCCAGCCCCGAGGAGGAGCAGGAGAAACCCATCCTCGACAGGCCAACCAGGATCTCCCAACCCGAAGA
CAGCAGGCAGCCCAATAATGTGATCAGACAGCCTTTGGGTCCTGATGGGTCTCAAGGCTTCAAACAGCGCAGATAAATGCAGGCAAGAAA
AGATGCCGCCGTTGCTGCCGTCACCGCCTCCTGGGTCGTCCGCCACGGGTTGCACTGCCGTGGCAGACAGCTGGACTTGAGCAGAGGGAA
CGACCTGACTTACTTGCACTGTGATCCCCCTTGCTCCGCCCACTGTGACCTTGAACCCCATGCACTGTGACCTCCCCCCTTCTCCCCCTT

>38151_38151_2_HYOU1-SZRD1_HYOU1_chr11_118922150_ENST00000404233_SZRD1_chr1_16717870_ENST00000471507_length(amino acids)=525AA_BP=
MSQSWGRRSGGKRGTMADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLK
ENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFA
EQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGM
QPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTR
VEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPF

--------------------------------------------------------------
>38151_38151_3_HYOU1-SZRD1_HYOU1_chr11_118922150_ENST00000529972_SZRD1_chr1_16717870_ENST00000401088_length(transcript)=5081nt_BP=1671nt
GAGAGGTTGGTGGCTAATGTAACAGTTTGCAAACCGAGAGGAGTTGTGAAGGGCGCGGGTGGGGGGCGCTGCCGGCCTCGTGGGTACGTT
CGTGCCGCGTCTGTCCCAGAGCTGGGGCCGCAGGAGCGGAGGCAAGAGGGGCACTATGGCAGACAAAGTTAGGAGGCAGAGGCCGAGGAG
GCGAGTCTGTTGGGCCTTGGTGGCTGTGCTCTTGGCAGACCTGTTGGCACTGAGTGATACACTGGCAGTGATGTCTGTGGACCTGGGCAG
TGAGTCCATGAAGGTGGCCATTGTCAAACCTGGAGTGCCCATGGAAATTGTCTTGAATAAGGAATCTCGGAGGAAAACACCGGTGATCGT
GACCCTGAAAGAAAATGAAAGATTCTTTGGAGACAGTGCAGCAAGCATGGCGATTAAGAATCCAAAGGCTACGCTACGTTACTTCCAGCA
CCTCCTGGGGAAGCAGGCAGATAACCCCCATGTAGCTCTTTACCAGGCCCGCTTCCCGGAGCACGAGCTGACTTTCGACCCACAGAGGCA
GACTGTGCACTTTCAGATCAGCTCGCAGCTGCAGTTCTCACCTGAGGAAGTGTTGGGCATGGTTCTCAATTATTCTCGTTCTCTAGCTGA
AGATTTTGCAGAGCAGCCCATCAAGGATGCAGTGATCACCGTGCCAGTCTTCTTCAACCAGGCCGAGCGCCGAGCTGTGCTGCAGGCTGC
TCGTATGGCTGGCCTCAAAGTGCTGCAGCTCATCAATGACAACACCGCCACTGCCCTCAGCTATGGTGTCTTCCGCCGGAAAGATATTAA
CACCACTGCCCAGAATATCATGTTCTATGACATGGGCTCAGGCAGCACCGTATGCACCATTGTGACCTACCAGATGGTGAAGACTAAGGA
AGCTGGGATGCAGCCACAGCTGCAGATCCGGGGAGTAGGATTTGACCGTACCCTGGGGGGCCTGGAGATGGAGCTCCGGCTTCGAGAACG
CCTGGCTGGGCTTTTCAATGAGCAGCGCAAGGGTCAGAGAGCAAAGGATGTGCGGGAGAACCCGCGTGCCATGGCCAAGCTGCTGCGTGA
GGCTAATCGGCTCAAAACCGTCCTCAGTGCCAACGCTGACCACATGGCACAGATTGAAGGCCTGATGGATGATGTGGACTTCAAGGCAAA
AGTGACTCGTGTGGAATTTGAGGAGTTGTGTGCAGACTTGTTTGAGCGGGTGCCTGGGCCTGTACAGCAGGCCCTCCAGAGTGCCGAAAT
GAGTCTGGATGAGATTGAGCAGGTGATCCTGGTGGGTGGGGCCACTCGGGTCCCCAGAGTTCAGGAGGTGCTGCTGAAGGCCGTGGGCAA
GGAGGAGCTGGGGAAGAACATCAATGCAGATGAAGCAGCCGCCATGGGGGCAGTGTACCAGGCAGCTGCGCTCAGCAAAGCCTTTAAAGT
GAAGCCATTTGTCGTCCGAGATGCAGTGGTCTACCCCATCCTGGTGGAGTTCACGAGGGAGGTGGAGGAGGAGCCTGGGATTCACAGCCT
GAAGCACAATAAACGGGTACTCTTCTCTCGGATGGGGCCCTACCCTCAACGCAAAGTCATCACCTTTAACCGCTACAGCCATGATTTCAA
CTTCCACATCAACTACGGCGACCTGGGCTTCCTGGGGCCTGAAGATCTTCGGAAATAGACAGACGGTTGGAAAAAAAACTGAAGATCACA
CAAAAAGAGAGCAGGAAATCCAAATCTCCTCCCAAAGTGCCCATTGTGATTCAGGACGATAGCCTTCCCGCGGGGCCCCCTCCACAGATC
CGCATCCTCAAGAGGCCCACCAGCAACGGTGTGGTCAGCAGCCCCAACTCCACCAGCAGGCCCACCCTTCCAGTCAAGTCCCTAGCACAG
CGAGAGGCCGAGTACGCCGAGGCCCGGAAGCGGATCCTGGGCAGCGCCAGCCCCGAGGAGGAGCAGGAGAAACCCATCCTCGACAGGCCA
ACCAGGATCTCCCAACCCGAAGACAGCAGGCAGCCCAATAATGTGATCAGACAGCCTTTGGGTCCTGATGGGTCTCAAGGCTTCAAACAG
CGCAGATAAATGCAGGCAAGAAAAGATGCCGCCGTTGCTGCCGTCACCGCCTCCTGGGTCGTCCGCCACGGGTTGCACTGCCGTGGCAGA
CAGCTGGACTTGAGCAGAGGGAACGACCTGACTTACTTGCACTGTGATCCCCCTTGCTCCGCCCACTGTGACCTTGAACCCCATGCACTG
TGACCTCCCCCCTTCTCCCCCTTCCCACTGTGATTGGCACATCGACAAGGGCTGTCCCAAGTCAATGGAAAGGGAAAGGGTGGGGGTTAG
GGGAAGGTTGGGGGGACCCAGCAAGGACTCAGAGAGTCAGACAGTGCCACTTGGCCACTTGGGGTAAAGCCAGTGCCAGCAATAACAGTT
TATCATGCTCATTAATTTGGGATTTCAAAACACAAATGAAAACTCACACCCACCCACCCCCAAGTGCATGTCTCCATCACTTAAAAAGTA
AGTTCCATTTGAAAATATCCTTTCTTTTTTTTTTCTTCCTATTTTTGTTTGTTTATACAAATATCTGATTTGCAAGAAAAAGTGCATGGG
AGGGGTTTTAGTGGTTTAATGAATTTTTAATTAAGAAAGGGTAGTTTGGTAGTCTACTTAAAAATGTTTCTGGGAAATTCACTAGAAACA
TTAACCAATAGGATTTTGGTGAGCTTAGCTTCTGTATTCCTACTGCCGCCCAGAAAAGGGGCAGGGCTCTGCAGCCGCCAGGACAGACGA
GCACCCCATGCCTATACCTCCCTCCCCGAGCTAAGTCCCAGGGCATCTGGGCCTTGCCTGGAGACTGGGCTAGCTCTGTAGGCTCGGAGA
GCCTGGGGAGGGTGCCAACCCCACCTCTAGTATTTTGGGAGATAGGGAAAGTGAACCGACTTCCCCTTCCCATACCCCTCAGGGTGGTTC
CCTACCAGCCAGGCTTACTACTTCTAGAAGAAAGCAGAGTGCCAGGGAGTGAGATTGCATCCCTGGGCTTAGAAGTGACGGAGAGAAGAC
TTGTTTAGTATTTTGCCATCAGCACAAGGAAAACCAGGAGAGAGTCTGCCTCCAGGACTCTGAGCCTTCTGCCTCGTATGTTCAGAAGGT
GGATAGGTCTTCCCACTCCAGCATGGCTTGAACTCTTAGGGGTCTGCAGTGCTCCATCTCCATTGGTGGCCCCAGCTCAGTAACTATACC
TGGTACATTTCCTGTGTGCAATCAGTACCTTGAAGGCAGAACATTCTGAATAAAGTTGGAAAAAGAACAGCTTTGCTTTGCAAAGATTGA
TGACAGACTGGTTCCTCAGAGGCCTAGGCTACCCGTCACCCCTTTTTCCAGAGCGAGGGCCTGGAATGAAGGCAGTTTATCCTCTGTCCC
TGGAGCCTGGGGTTTGCTTTGGCTCCTTGAGGTGGAAGAGACTAAGAGGGCAGCTGCCCAGAGCAGCTGTGTGTACCTGGCTCCTCTCAG
GCTTCCTGATCCCTTCCGTTGCACTGCGCCTTATCCCTCAGCCAGCCAGACAGCCTCCCTGCTCCTGACCAGCAGATACGTTTCGGAGTG
GTTGGTGTGGTTTTTGTGATGAGGGCAGCACGTGGTGGCCAAGGTGGCAAGCTGAGTCTCACAGGCTCACTCCCTCGTTGGTTCCCTGTG
GGAATGGTAGGCCAGGCCCAGTAAGCCATGCCCCAACACGTCCTCTCCTCCGGAGGAAGGGCCAGCTGCCAGCTGAGTCAGCAGCTAGTC
CATAGCACAGCCTTATAACTGTAAAGCCAGGCATTGCCCATGAGCAGAGCTGGAACCAGAGCTTCAGTCAGTAAGAGGGAGGATTACCTT
CAGGAGAAGGCAAGGAAGAAAACTGGCTGCTATCTTTATAGTTCCACTGCCCTAACCAAGTGTCCACATTCTAAATGTGTAGTGTCCATC
CCTTATGTAATAGTGGTTTCCCGCCCAAAGTGAGACTTTCCTTTTAATTGGAGAAGGGTATAGAGGTAGTCCAGGTGGGAACGCCAGAAG
TGCTGATTGCCCAGCCATTGGGACCACCTGTTCTTGCCCCACTACCCTCTAGTGGGAGGCCAAAGTAAAGGCTGGCTGGTGGGTGTCTGT
GGATTGAGGATGTGGCAGGGACTGGTCCTCCCACCTCCCTCTGGCCAAAGATGGGCTTTGCCCGCTGTGTGCCTGTCACCACCCACCAGC
AGTCATGCCCTGGGCTTCCCAAATGGAGAGGTAGCAGGCAACGTTTTTAAAAAGAAAGAAAACAGGAAACTGTATTGTGTCGGGGGAGGC
GGGAGGGAGATGAGGAAACGGTTTGGATTTTGTGTGTGGGAGGGTATTTTTTGGGGGTAGTTGTCTGTAACTTTCCTAAGTGCTTTTTTT
CCTTTTCTTTTTTAAAGTAAGTTGCAGGCTTTGGCTTGGAAAACCCCAGGGGGATGGGGGGCAGAAACCTGAGGCTGCTGCCCCTTTATC
TGCCTTCACGGTACTGTCCCCTTCCCCCAGCTCCTCCCTGACCCCATGGGCCAGGCCTCAGACCTTCCAGCTAACCGCTTCCCATGAGCC
ACTACTCTGATGTCAGCCTATAACCAAAGGAGCTGGGGGGTCCAGGCCTGGTGACCAACCTTTCTCAGCCCACTCAATCAGGGTGCTCCC
CACCTGCAGGCAGGAGGCAACACCCTATCTGCTACCATCAGCCCCTTCCAGAGCCCATCTGCCCCGCCCAGCCCTGCCCTGCCCAGCCAT
ACCCTGCTCTGCCCCATCTGGGGGTGCCCTGCTCAGGGATGGGCTGGCAGGGCTGTACCCAGCCTCCCTGGTAAGCAGAGACTCAAGAAA
CCTCTGGGGTCCTGTTTTCTGGTCGTGTGATCCCAGGGGTGCACATGGGCCCCTTGGGTGTCTGAACAGAAGGGCATGGGAGGGAGGGCT
GCACCCCTGCAGTCTTACTCTGCTGGTGTAGCGGGCAGCTGCCCACTCCCACCCCACCCTGCACCGCGGGCTCCTGAGTCGGCAGATTAA

>38151_38151_3_HYOU1-SZRD1_HYOU1_chr11_118922150_ENST00000529972_SZRD1_chr1_16717870_ENST00000401088_length(amino acids)=525AA_BP=
MSQSWGRRSGGKRGTMADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLK
ENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFA
EQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGM
QPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTR
VEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPF

--------------------------------------------------------------
>38151_38151_4_HYOU1-SZRD1_HYOU1_chr11_118922150_ENST00000529972_SZRD1_chr1_16717870_ENST00000471507_length(transcript)=2342nt_BP=1671nt
GAGAGGTTGGTGGCTAATGTAACAGTTTGCAAACCGAGAGGAGTTGTGAAGGGCGCGGGTGGGGGGCGCTGCCGGCCTCGTGGGTACGTT
CGTGCCGCGTCTGTCCCAGAGCTGGGGCCGCAGGAGCGGAGGCAAGAGGGGCACTATGGCAGACAAAGTTAGGAGGCAGAGGCCGAGGAG
GCGAGTCTGTTGGGCCTTGGTGGCTGTGCTCTTGGCAGACCTGTTGGCACTGAGTGATACACTGGCAGTGATGTCTGTGGACCTGGGCAG
TGAGTCCATGAAGGTGGCCATTGTCAAACCTGGAGTGCCCATGGAAATTGTCTTGAATAAGGAATCTCGGAGGAAAACACCGGTGATCGT
GACCCTGAAAGAAAATGAAAGATTCTTTGGAGACAGTGCAGCAAGCATGGCGATTAAGAATCCAAAGGCTACGCTACGTTACTTCCAGCA
CCTCCTGGGGAAGCAGGCAGATAACCCCCATGTAGCTCTTTACCAGGCCCGCTTCCCGGAGCACGAGCTGACTTTCGACCCACAGAGGCA
GACTGTGCACTTTCAGATCAGCTCGCAGCTGCAGTTCTCACCTGAGGAAGTGTTGGGCATGGTTCTCAATTATTCTCGTTCTCTAGCTGA
AGATTTTGCAGAGCAGCCCATCAAGGATGCAGTGATCACCGTGCCAGTCTTCTTCAACCAGGCCGAGCGCCGAGCTGTGCTGCAGGCTGC
TCGTATGGCTGGCCTCAAAGTGCTGCAGCTCATCAATGACAACACCGCCACTGCCCTCAGCTATGGTGTCTTCCGCCGGAAAGATATTAA
CACCACTGCCCAGAATATCATGTTCTATGACATGGGCTCAGGCAGCACCGTATGCACCATTGTGACCTACCAGATGGTGAAGACTAAGGA
AGCTGGGATGCAGCCACAGCTGCAGATCCGGGGAGTAGGATTTGACCGTACCCTGGGGGGCCTGGAGATGGAGCTCCGGCTTCGAGAACG
CCTGGCTGGGCTTTTCAATGAGCAGCGCAAGGGTCAGAGAGCAAAGGATGTGCGGGAGAACCCGCGTGCCATGGCCAAGCTGCTGCGTGA
GGCTAATCGGCTCAAAACCGTCCTCAGTGCCAACGCTGACCACATGGCACAGATTGAAGGCCTGATGGATGATGTGGACTTCAAGGCAAA
AGTGACTCGTGTGGAATTTGAGGAGTTGTGTGCAGACTTGTTTGAGCGGGTGCCTGGGCCTGTACAGCAGGCCCTCCAGAGTGCCGAAAT
GAGTCTGGATGAGATTGAGCAGGTGATCCTGGTGGGTGGGGCCACTCGGGTCCCCAGAGTTCAGGAGGTGCTGCTGAAGGCCGTGGGCAA
GGAGGAGCTGGGGAAGAACATCAATGCAGATGAAGCAGCCGCCATGGGGGCAGTGTACCAGGCAGCTGCGCTCAGCAAAGCCTTTAAAGT
GAAGCCATTTGTCGTCCGAGATGCAGTGGTCTACCCCATCCTGGTGGAGTTCACGAGGGAGGTGGAGGAGGAGCCTGGGATTCACAGCCT
GAAGCACAATAAACGGGTACTCTTCTCTCGGATGGGGCCCTACCCTCAACGCAAAGTCATCACCTTTAACCGCTACAGCCATGATTTCAA
CTTCCACATCAACTACGGCGACCTGGGCTTCCTGGGGCCTGAAGATCTTCGGAAATAGACAGACGGTTGGAAAAAAAACTGAAGATCACA
CAAAAAGAGAGGAAATCCAAATCTCCTCCCAAAGTGCCCATTGTGATTCAGGACGATAGCCTTCCCGCGGGGCCCCCTCCACAGATCCGC
ATCCTCAAGAGGCCCACCAGCAACGGTGTGGTCAGCAGCCCCAACTCCACCAGCAGGCCCACCCTTCCAGTCAAGTCCCTAGCACAGCGA
GAGGCCGAGTACGCCGAGGCCCGGAAGCGGATCCTGGGCAGCGCCAGCCCCGAGGAGGAGCAGGAGAAACCCATCCTCGACAGGCCAACC
AGGATCTCCCAACCCGAAGACAGCAGGCAGCCCAATAATGTGATCAGACAGCCTTTGGGTCCTGATGGGTCTCAAGGCTTCAAACAGCGC
AGATAAATGCAGGCAAGAAAAGATGCCGCCGTTGCTGCCGTCACCGCCTCCTGGGTCGTCCGCCACGGGTTGCACTGCCGTGGCAGACAG
CTGGACTTGAGCAGAGGGAACGACCTGACTTACTTGCACTGTGATCCCCCTTGCTCCGCCCACTGTGACCTTGAACCCCATGCACTGTGA
CCTCCCCCCTTCTCCCCCTTCCCACTGTGATTGGCACATCGACAAGGGCTGTCCCAAGTCAATGGAAAGGGAAAGGGTGGGGGTTAGGGG

>38151_38151_4_HYOU1-SZRD1_HYOU1_chr11_118922150_ENST00000529972_SZRD1_chr1_16717870_ENST00000471507_length(amino acids)=525AA_BP=
MSQSWGRRSGGKRGTMADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLK
ENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFA
EQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGM
QPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTR
VEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HYOU1-SZRD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for HYOU1-SZRD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for HYOU1-SZRD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source