FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ICMT-ACOT7 (FusionGDB2 ID:38211)

Fusion Gene Summary for ICMT-ACOT7

check button Fusion gene summary
Fusion gene informationFusion gene name: ICMT-ACOT7
Fusion gene ID: 38211
HgeneTgene
Gene symbol

ICMT

ACOT7

Gene ID

23463

11332

Gene nameisoprenylcysteine carboxyl methyltransferaseacyl-CoA thioesterase 7
SynonymsHSTE14|MST098|MSTP098|PCCMT|PCMT|PPMTACH1|ACT|BACH|CTE-II|LACH|LACH1|hBACH
Cytomap

1p36.31

1p36.31

Type of geneprotein-codingprotein-coding
Descriptionprotein-S-isoprenylcysteine O-methyltransferaseprenylated protein carboxyl methyltransferaseprenylcysteine carboxyl methyltransferasecytosolic acyl coenzyme A thioester hydrolaseCTE-IIaacyl-CoA thioesterase 2acyl-CoA thioesterase, long chainbrain acyl-CoA hydrolaselong chain acyl-CoA thioester hydrolase
Modification date2020031320200313
UniProtAcc

O60725

O00154

Ensembl transtripts involved in fusion geneENST00000343813, ENST00000362035, 
ENST00000495791, 		ENST00000541130, 
ENST00000361521, ENST00000377842, 
ENST00000377845, ENST00000377855, 
ENST00000545482, ENST00000608083, 
Fusion gene scores* DoF score5 X 5 X 4=1009 X 8 X 7=504
# samples 613
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/504*10)=-1.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ICMT [Title/Abstract] AND ACOT7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointICMT(6291962)-ACOT7(6324755), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACOT7

GO:0015937

coenzyme A biosynthetic process

10578051

TgeneACOT7

GO:0036114

medium-chain fatty-acyl-CoA catabolic process

10578051

TgeneACOT7

GO:0036116

long-chain fatty-acyl-CoA catabolic process

10578051

TgeneACOT7

GO:0051792

medium-chain fatty acid biosynthetic process

10578051

TgeneACOT7

GO:1900535

palmitic acid biosynthetic process

10578051


check buttonFusion gene breakpoints across ICMT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACOT7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26G-01AICMTchr1

6294946

-ACOT7chr1

6378638

-
ChimerDB4TGCTTCGA-2G-AAG8-01AICMTchr1

6291962

-ACOT7chr1

6324755

-
ChimerDB4TGCTTCGA-2G-AAG8ICMTchr1

6291962

-ACOT7chr1

6324755

-


Top

Fusion Gene ORF analysis for ICMT-ACOT7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000343813ENST00000541130ICMTchr1

6291962

-ACOT7chr1

6324755

-
Frame-shiftENST00000343813ENST00000361521ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000343813ENST00000377842ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000343813ENST00000377842ICMTchr1

6291962

-ACOT7chr1

6324755

-
Frame-shiftENST00000343813ENST00000377845ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000343813ENST00000377855ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000343813ENST00000377855ICMTchr1

6291962

-ACOT7chr1

6324755

-
Frame-shiftENST00000343813ENST00000541130ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000343813ENST00000545482ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000343813ENST00000545482ICMTchr1

6291962

-ACOT7chr1

6324755

-
Frame-shiftENST00000343813ENST00000608083ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000343813ENST00000608083ICMTchr1

6291962

-ACOT7chr1

6324755

-
Frame-shiftENST00000362035ENST00000361521ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000362035ENST00000377842ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000362035ENST00000377845ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000362035ENST00000377855ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000362035ENST00000541130ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000362035ENST00000545482ICMTchr1

6294946

-ACOT7chr1

6378638

-
Frame-shiftENST00000362035ENST00000608083ICMTchr1

6294946

-ACOT7chr1

6378638

-
In-frameENST00000343813ENST00000361521ICMTchr1

6291962

-ACOT7chr1

6324755

-
In-frameENST00000343813ENST00000377845ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-3CDSENST00000362035ENST00000361521ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-3CDSENST00000362035ENST00000377842ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-3CDSENST00000362035ENST00000377845ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-3CDSENST00000362035ENST00000377855ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-3CDSENST00000362035ENST00000545482ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-3CDSENST00000362035ENST00000608083ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-3CDSENST00000495791ENST00000361521ICMTchr1

6294946

-ACOT7chr1

6378638

-
intron-3CDSENST00000495791ENST00000361521ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-3CDSENST00000495791ENST00000377842ICMTchr1

6294946

-ACOT7chr1

6378638

-
intron-3CDSENST00000495791ENST00000377842ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-3CDSENST00000495791ENST00000377845ICMTchr1

6294946

-ACOT7chr1

6378638

-
intron-3CDSENST00000495791ENST00000377845ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-3CDSENST00000495791ENST00000377855ICMTchr1

6294946

-ACOT7chr1

6378638

-
intron-3CDSENST00000495791ENST00000377855ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-3CDSENST00000495791ENST00000541130ICMTchr1

6294946

-ACOT7chr1

6378638

-
intron-3CDSENST00000495791ENST00000545482ICMTchr1

6294946

-ACOT7chr1

6378638

-
intron-3CDSENST00000495791ENST00000545482ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-3CDSENST00000495791ENST00000608083ICMTchr1

6294946

-ACOT7chr1

6378638

-
intron-3CDSENST00000495791ENST00000608083ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-intronENST00000362035ENST00000541130ICMTchr1

6291962

-ACOT7chr1

6324755

-
intron-intronENST00000495791ENST00000541130ICMTchr1

6291962

-ACOT7chr1

6324755

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ICMT-ACOT7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ICMT-ACOT7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:6291962/chr1:6324755)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ICMT

O60725

ACOT7

O00154

FUNCTION: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. {ECO:0000269|PubMed:9614111}.FUNCTION: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:10578051). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:10578051). May play an important physiological function in brain (PubMed:10578051). {ECO:0000269|PubMed:10578051, ECO:0000303|PubMed:10578051}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-45197_200224285.0RegionS-adenosyl-L-methionine binding
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-45210_213224285.0RegionS-adenosyl-L-methionine binding
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-45113_131224285.0Topological domainCytoplasmic
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-45150_154224285.0Topological domainLumenal
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-45175_212224285.0Topological domainCytoplasmic
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-451_16224285.0Topological domainCytoplasmic
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-4534_41224285.0Topological domainLumenal
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-4560_69224285.0Topological domainCytoplasmic
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-4588_92224285.0Topological domainLumenal
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-45132_149224285.0TransmembraneHelical
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-45155_174224285.0TransmembraneHelical
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-4517_33224285.0TransmembraneHelical
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-4542_59224285.0TransmembraneHelical
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-4570_87224285.0TransmembraneHelical
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-4593_112224285.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-45229_229224285.0Topological domainLumenal
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-45245_284224285.0Topological domainCytoplasmic
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-45213_228224285.0TransmembraneHelical
HgeneICMTchr1:6291962chr1:6324755ENST00000343813-45230_244224285.0TransmembraneHelical
TgeneACOT7chr1:6291962chr1:6324755ENST0000036152179224_338338371.0DomainHotDog ACOT-type 2
TgeneACOT7chr1:6291962chr1:6324755ENST000003615217950_168338371.0DomainHotDog ACOT-type 1
TgeneACOT7chr1:6291962chr1:6324755ENST0000037784279224_338297330.0DomainHotDog ACOT-type 2
TgeneACOT7chr1:6291962chr1:6324755ENST000003778427950_168297330.0DomainHotDog ACOT-type 1
TgeneACOT7chr1:6291962chr1:6324755ENST0000037784579224_338318351.0DomainHotDog ACOT-type 2
TgeneACOT7chr1:6291962chr1:6324755ENST000003778457950_168318351.0DomainHotDog ACOT-type 1
TgeneACOT7chr1:6291962chr1:6324755ENST0000037785579224_338348381.0DomainHotDog ACOT-type 2
TgeneACOT7chr1:6291962chr1:6324755ENST000003778557950_168348381.0DomainHotDog ACOT-type 1


Top

Fusion Gene Sequence for ICMT-ACOT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ICMT-ACOT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ICMT-ACOT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ICMT-ACOT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource