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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ICOSLG-KCNJ6 (FusionGDB2 ID:38219) |
Fusion Gene Summary for ICOSLG-KCNJ6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ICOSLG-KCNJ6 | Fusion gene ID: 38219 | Hgene | Tgene | Gene symbol | ICOSLG | KCNJ6 | Gene ID | 23308 | 3763 |
| Gene name | inducible T cell costimulator ligand | potassium inwardly rectifying channel subfamily J member 6 | |
| Synonyms | B7-H2|B7H2|B7RP-1|B7RP1|B7h|CD275|GL50|ICOS-L|ICOSL|LICOS | BIR1|GIRK-2|GIRK2|KATP-2|KATP2|KCNJ7|KIR3.2|KPLBS|hiGIRK2 | |
| Cytomap | 21q22.3 | 21q22.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ICOS ligandB7 homolog 2B7 homologue 2B7-like protein Gl50B7-related protein 1transmembrane protein B7-H2 ICOS ligand | G protein-activated inward rectifier potassium channel 2inward rectifier K(+) channel Kir3.2inward rectifier potassium channel KIR3.2potassium channel, inwardly rectifying subfamily J, member 6potassium voltage-gated channel subfamily J member 6 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | O75144 | P48051 | |
| Ensembl transtripts involved in fusion gene | ENST00000344330, ENST00000400377, ENST00000407780, ENST00000400379, | ENST00000288309, ENST00000609713, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 13 X 9 X 6=702 |
| # samples | 2 | 14 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(14/702*10)=-2.32604420335959 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ICOSLG [Title/Abstract] AND KCNJ6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ICOSLG(45649937)-KCNJ6(39087434), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across ICOSLG (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KCNJ6 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A7-A13D-01A | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - |
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Fusion Gene ORF analysis for ICOSLG-KCNJ6 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000344330 | ENST00000288309 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - |
| In-frame | ENST00000344330 | ENST00000609713 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - |
| In-frame | ENST00000400377 | ENST00000288309 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - |
| In-frame | ENST00000400377 | ENST00000609713 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - |
| In-frame | ENST00000407780 | ENST00000288309 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - |
| In-frame | ENST00000407780 | ENST00000609713 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - |
| intron-3CDS | ENST00000400379 | ENST00000288309 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - |
| intron-3CDS | ENST00000400379 | ENST00000609713 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000344330 | ICOSLG | chr21 | 45649937 | - | ENST00000609713 | KCNJ6 | chr21 | 39087434 | - | 19951 | 921 | 23 | 2167 | 714 |
| ENST00000344330 | ICOSLG | chr21 | 45649937 | - | ENST00000288309 | KCNJ6 | chr21 | 39087434 | - | 2168 | 921 | 23 | 2167 | 715 |
| ENST00000407780 | ICOSLG | chr21 | 45649937 | - | ENST00000609713 | KCNJ6 | chr21 | 39087434 | - | 20056 | 1026 | 128 | 2272 | 714 |
| ENST00000407780 | ICOSLG | chr21 | 45649937 | - | ENST00000288309 | KCNJ6 | chr21 | 39087434 | - | 2273 | 1026 | 128 | 2272 | 715 |
| ENST00000400377 | ICOSLG | chr21 | 45649937 | - | ENST00000609713 | KCNJ6 | chr21 | 39087434 | - | 19726 | 696 | 149 | 1942 | 597 |
| ENST00000400377 | ICOSLG | chr21 | 45649937 | - | ENST00000288309 | KCNJ6 | chr21 | 39087434 | - | 1943 | 696 | 149 | 1942 | 598 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000344330 | ENST00000609713 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - | 0.000169665 | 0.99983037 |
| ENST00000344330 | ENST00000288309 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - | 0.002091679 | 0.99790835 |
| ENST00000407780 | ENST00000609713 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - | 0.000168311 | 0.9998317 |
| ENST00000407780 | ENST00000288309 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - | 0.001967514 | 0.9980325 |
| ENST00000400377 | ENST00000609713 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - | 0.000147658 | 0.9998523 |
| ENST00000400377 | ENST00000288309 | ICOSLG | chr21 | 45649937 | - | KCNJ6 | chr21 | 39087434 | - | 0.002257389 | 0.99774265 |
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Fusion Genomic Features for ICOSLG-KCNJ6 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ICOSLG-KCNJ6 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:45649937/chr21:39087434) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ICOSLG | KCNJ6 |
| FUNCTION: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). {ECO:0000250}. | FUNCTION: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ICOSLG | chr21:45649937 | chr21:39087434 | ENST00000344330 | - | 6 | 7 | 141_227 | 299 | 310.0 | Domain | Note=Ig-like C2-type |
| Hgene | ICOSLG | chr21:45649937 | chr21:39087434 | ENST00000344330 | - | 6 | 7 | 19_129 | 299 | 310.0 | Domain | Note=Ig-like V-type |
| Hgene | ICOSLG | chr21:45649937 | chr21:39087434 | ENST00000407780 | - | 6 | 7 | 141_227 | 299 | 303.0 | Domain | Note=Ig-like C2-type |
| Hgene | ICOSLG | chr21:45649937 | chr21:39087434 | ENST00000407780 | - | 6 | 7 | 19_129 | 299 | 303.0 | Domain | Note=Ig-like V-type |
| Hgene | ICOSLG | chr21:45649937 | chr21:39087434 | ENST00000344330 | - | 6 | 7 | 19_256 | 299 | 310.0 | Topological domain | Extracellular |
| Hgene | ICOSLG | chr21:45649937 | chr21:39087434 | ENST00000344330 | - | 6 | 7 | 278_302 | 299 | 310.0 | Topological domain | Cytoplasmic |
| Hgene | ICOSLG | chr21:45649937 | chr21:39087434 | ENST00000407780 | - | 6 | 7 | 19_256 | 299 | 303.0 | Topological domain | Extracellular |
| Hgene | ICOSLG | chr21:45649937 | chr21:39087434 | ENST00000407780 | - | 6 | 7 | 278_302 | 299 | 303.0 | Topological domain | Cytoplasmic |
| Hgene | ICOSLG | chr21:45649937 | chr21:39087434 | ENST00000344330 | - | 6 | 7 | 257_277 | 299 | 310.0 | Transmembrane | Helical |
| Hgene | ICOSLG | chr21:45649937 | chr21:39087434 | ENST00000407780 | - | 6 | 7 | 257_277 | 299 | 303.0 | Transmembrane | Helical |
| Tgene | KCNJ6 | chr21:45649937 | chr21:39087434 | ENST00000288309 | 1 | 4 | 139_150 | 8 | 424.0 | Intramembrane | Helical%3B Pore-forming%3B Name%3DH5 | |
| Tgene | KCNJ6 | chr21:45649937 | chr21:39087434 | ENST00000288309 | 1 | 4 | 151_157 | 8 | 424.0 | Intramembrane | Pore-forming | |
| Tgene | KCNJ6 | chr21:45649937 | chr21:39087434 | ENST00000288309 | 1 | 4 | 152_157 | 8 | 424.0 | Motif | Selectivity filter | |
| Tgene | KCNJ6 | chr21:45649937 | chr21:39087434 | ENST00000288309 | 1 | 4 | 420_423 | 8 | 424.0 | Motif | Note=PDZ-binding | |
| Tgene | KCNJ6 | chr21:45649937 | chr21:39087434 | ENST00000288309 | 1 | 4 | 115_138 | 8 | 424.0 | Topological domain | Extracellular | |
| Tgene | KCNJ6 | chr21:45649937 | chr21:39087434 | ENST00000288309 | 1 | 4 | 158_166 | 8 | 424.0 | Topological domain | Extracellular | |
| Tgene | KCNJ6 | chr21:45649937 | chr21:39087434 | ENST00000288309 | 1 | 4 | 189_423 | 8 | 424.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNJ6 | chr21:45649937 | chr21:39087434 | ENST00000288309 | 1 | 4 | 167_188 | 8 | 424.0 | Transmembrane | Helical%3B Name%3DM2 | |
| Tgene | KCNJ6 | chr21:45649937 | chr21:39087434 | ENST00000288309 | 1 | 4 | 90_114 | 8 | 424.0 | Transmembrane | Helical%3B Name%3DM1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KCNJ6 | chr21:45649937 | chr21:39087434 | ENST00000288309 | 1 | 4 | 1_89 | 8 | 424.0 | Topological domain | Cytoplasmic |
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Fusion Gene Sequence for ICOSLG-KCNJ6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >38219_38219_1_ICOSLG-KCNJ6_ICOSLG_chr21_45649937_ENST00000344330_KCNJ6_chr21_39087434_ENST00000288309_length(transcript)=2168nt_BP=921nt GGCCCGAGGTCTCCGCCCGCACCATGCGGCTGGGCAGTCCTGGACTGCTCTTCCTGCTCTTCAGCAGCCTTCGAGCTGATACTCAGGAGA AGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCGCTTGCCCTGAAGGAAGCCGTTTTGATTTAAATGATGTTTACGTAT ATTGGCAAACCAGTGAGTCGAAAACCGTGGTGACCTACCACATCCCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTACCGGAACC GAGCCCTGATGTCACCGGCCGGCATGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACGTCACCCCCCAGGACGAGCAGAAGTTTCACT GCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCGTTGAGGTTACACTGCATGTGGCAGCAAACTTCAGCGTGCCCGTCG TCAGCGCCCCCCACAGCCCCTCCCAGGATGAGCTCACCTTCACGTGTACATCCATAAACGGCTACCCCAGGCCCAACGTGTACTGGATCA ATAAGACGGACAACAGCCTGCTGGACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATGCGGGGCTTGTATGACGTGGTCAGCGTGC TGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAACGTGCTTCTGCAGCAGAACCTGACTGTCGGCAGCCAGACAG GAAATGACATCGGAGAGAGAGACAAGATCACAGAGAATCCAGTCAGTACCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCTGTCC TGTGCCTGCTTGTGGTCGTGGCGGTGGCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACACAGCTATGCAGGTGCCTGGGCTGTGA GTCCGGAGACAGAGCTCACTGCTAACGTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTGGCCATTCACCAGCCAAAGT TGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGGTACGTGAGGAAAGACGGAA AGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTGGACCTGAAGTGGAGATTCA ACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCATACATACGGGGAGACATGG ACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTCTCAATAGAGACAGAAACCA CCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCTGTGTTGGGGTCCATTGTCA ATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTTTCCACCCATGCAGTGATCT CCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCTTCCATCAGAGCCAAGTTGA TCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTACACGGGGGATGACCGTCTGT TTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCCCAGCTGCCCAAAGAGGAAC TGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTACATCACCAGTGAGATCCTGT GGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCATGAGACCTATGAGACCAGCA CCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTATCCAGCAAACTCAACCAAC ATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCAAACCTGGAGAATGAATCCA >38219_38219_1_ICOSLG-KCNJ6_ICOSLG_chr21_45649937_ENST00000344330_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=715AA_BP=299 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAG MLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVA VAIGWVCRDRCLQHSYAGAWAVSPETELTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGN VRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRV ITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSE GEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPV -------------------------------------------------------------- >38219_38219_2_ICOSLG-KCNJ6_ICOSLG_chr21_45649937_ENST00000344330_KCNJ6_chr21_39087434_ENST00000609713_length(transcript)=19951nt_BP=921nt GGCCCGAGGTCTCCGCCCGCACCATGCGGCTGGGCAGTCCTGGACTGCTCTTCCTGCTCTTCAGCAGCCTTCGAGCTGATACTCAGGAGA AGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCGCTTGCCCTGAAGGAAGCCGTTTTGATTTAAATGATGTTTACGTAT ATTGGCAAACCAGTGAGTCGAAAACCGTGGTGACCTACCACATCCCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTACCGGAACC GAGCCCTGATGTCACCGGCCGGCATGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACGTCACCCCCCAGGACGAGCAGAAGTTTCACT GCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCGTTGAGGTTACACTGCATGTGGCAGCAAACTTCAGCGTGCCCGTCG TCAGCGCCCCCCACAGCCCCTCCCAGGATGAGCTCACCTTCACGTGTACATCCATAAACGGCTACCCCAGGCCCAACGTGTACTGGATCA ATAAGACGGACAACAGCCTGCTGGACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATGCGGGGCTTGTATGACGTGGTCAGCGTGC TGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAACGTGCTTCTGCAGCAGAACCTGACTGTCGGCAGCCAGACAG GAAATGACATCGGAGAGAGAGACAAGATCACAGAGAATCCAGTCAGTACCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCTGTCC TGTGCCTGCTTGTGGTCGTGGCGGTGGCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACACAGCTATGCAGGTGCCTGGGCTGTGA GTCCGGAGACAGAGCTCACTGCTAACGTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTGGCCATTCACCAGCCAAAGT TGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGGTACGTGAGGAAAGACGGAA AGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTGGACCTGAAGTGGAGATTCA ACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCATACATACGGGGAGACATGG ACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTCTCAATAGAGACAGAAACCA CCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCTGTGTTGGGGTCCATTGTCA ATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTTTCCACCCATGCAGTGATCT CCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCTTCCATCAGAGCCAAGTTGA TCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTACACGGGGGATGACCGTCTGT TTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCCCAGCTGCCCAAAGAGGAAC TGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTACATCACCAGTGAGATCCTGT GGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCATGAGACCTATGAGACCAGCA CCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTATCCAGCAAACTCAACCAAC ATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCAAACCTGGAGAATGAATCCA AAGTTTAGTGCCCTAGCTGGGCAAACCCTTCTCTTCTCCCCCCAACACAATCTTTCCTTGTCTCTCATTCTCTTTCTTTTTCTGTCTCTC TTGCTTTGTTCTTTATTTGTTTATATTTAATTTTTACATGACCAGAAAACAAATCTTCAAGGTGTAAAATATCTACCTGCCCTCTCTCAG TTATTCAGATTGACAAGGTAGACATGGATTTGATGAAAGTGCAAAGTGCCCTCATTTGTGGCCCAAGCCTGGTCTCCTCCCAAAATACTA CACATCCAACTCCTGGAGATTTCAGTTACTTACCTGCATGTGTTGTACAATACCAGATCACTCAAAAAGGTGTGTCAAAGATTTTACCTG GGATATGACAAGCAAGGTTTCTGGTGCCTATTTATTCATTCAGTGAGACACAGAGTGGAGCCCTCAGTTTTATGGATCCCAATTCATTTC ATCTACTACAGGGTGAGGTGCTTGCCCCCATGTGGGTGTGGCAGTTACAGGGCCCAGGTGAGCTGAAGACAAACCACTGTACATATATAT GCCTTATGTAATTATTTTCTTTTTGTAATTAGTAATAAAACCCAGCATGTACAAAAGTACCATAGAACAGAACTGCTAAATACTGTACAT AGATGTATCATTAATGTAGGTTTAGATATATAACTTTAGAAATAAGAAGCAAAAAAAAAAAGAAAGAAAGAAAGATTCCTAACATGCAGT AGGCATTTCTGTTTTGATGTCTGTGTTTTCCAGGTTATTTTGATCCAGTTGACGGCTGGCCCTTCAGTGCATGGCCTTTGTTTGTGTCTC AGACTGGCAGACGTTAGGGTACCTCACTGTTCCCACACGGATCCTTTCATTGAATCCAACAAGCCATAGGTCTGGGGGAAATTGAGAGGT CTGGTAGATGGCAAAACCCACCACCAATATGCTGATATACTGTGAAATGTTACAAAACAGATGTCTTTTTTTAAAAGATAACAAGGGCCT CACTAACTGGCCTGGAGGAGGGGGAATACCAGGAAGGAAATATTCTCTAGCCTGTCACCAAAGGTATGTTTTTACTTTTCACATGAGCTC TTGCCCTTTGTAGTACAATAATTTAGGAAACTTTTCTGCAAAACCATTGATTCTCCAGCTGTAGTTTCTCTACACTCTTACAATGAGACA TGGTAAGTTAGCAGAAGATGGTTTGGGTCTAAAGCCGTGAAATTCACAAAGGCATGTAGTGAGTGGCATGCATTATAATCATCGACCTCT CACTTTGACTCTATCTGGCTTTCTGAGAATGACATCTCGCCTGTCCCTGGGGCTTATCCATCAGCATTTCTTGCATTGTGATCTTTTATT ATTTTGAAATGACCAGAGTTCAGTATTCAAAGATTAGATCAACAATCTTGATGATTGTCTAAGAAATGTCTCTAGAGTATGCCACAGGCT AGAAATCAAATCCAGTGTCTGTCAATCAAAAGAAAACAAATAAAAAAATTCCAGCCTTAATTCACTTTAATCTGCAAAAAGGAAAGAAGG GAGGAAGGGAGGGAGGAAGGAAGGAAGGAAGGAAGGGTATTTGTACTGGAAATCTGAATTTTAAAATGAAAAAAATAAGGAAACAAATCT TAGATCAAACCTCCGGGGCAGGTGGAGATTTTGCACTGTTACAGATCTTTCACATTCACTTTGCATTTATAAGCTGTTTGTTCTTTAACA CAGTTGCCCATCATAAATATTCATTGAATGGATCCAAGTTTATTTTCAGCTCCTACAGCTGTGCTCAGTTTGAGGCTCTGCACCATGGAG GTCAAAGAGATCAAACTAGCTGTCCCTCTTTGTTTCCCTTGCCTTCCCTGACCTGATCGCACAGGCCTTTGGTGTAGTCTGGGGACCTTG TCTACTAAAAAAGAAGTCCCAGGATAAGGAAAGTGGCTCCTAAATATAACCTCGGGGCCTCTCTTCTCCCATCTCAGAGACCTTGGATCA GGACAACTGCCTCTTGGCACTGACTTTAAGGAAAACAAAACTGTTGGCTATAGCCCTTTCCTGTTTGCCAGCATTTCCTTTTTTGCATTG AATCTCTGTTGAATCATTTCTTTATTTCGCACACTCTAAGAAGGAGGTGGTGGTCCGGGAGGAGGAAGCTCGATACACTCCCCTTGAGGC TGCGGGGAGGAGCCATGGCTTGACCTCTCTGCAGCCTAATGAAGGGCACTCTTGGCTTGGGGAGCTCCCCTGCAACCTTGCCAGGGTCGC AGGGCAGGCCATGGCAGGCACAAAACAAGATGGAATAGGGGCGGCAAAATGTCTTCTAATTTAGCTCTTGAAGACTCACTGGGCCTTTTT AATTCCATTGCTAAGGTTTAAAGGACAGCGCACACCCCCGTGTCTGGTTGGAAGAGCAAGCAGCTCAGGGCCTCATCCCTGCTTGCCTGC CCTTTAGCACAACTGAACGAAGAGCCTTGACAACACGTTGGCCACGTGCACCTGTCAGTTCTGTGTCTGTGACGGGCACCCAGATGTGAG GTCTCTCCCTGTTTCTCACTGTCTTTGTTGTCAATGTAGTTGGAGACAGAACTTGAACCAAATCTCGTTTTTGTAATGTGAGCCTCTGAA TCTTTACATGGGGATGCTCCTGAAGAACCTTTTACTAGAATGTCCCTATCAAACATGTCTATTTTTCTACAGTTGTTAACACAGTTTAAC AGTGTATTTTGTGTCAACTGTTAAAATTTGGAACTGAAAGTTCATTGAGACTGATTTTCTAAGCAGCGAGTAGTGAGTGAATGGTGTTTT CCATTAAGACAGCTCAACAAAATTGACCCCACAATTTCCACTCATTCTATTCCGCAATATCCAGTCCTCATTCCCTCAGTCACTCCATTA GCAAACCAAGTGCAATGAGAATTTTTTAAAAGTCTCTTTTAATACAACAGTATCCATAACTAATGAAGATCACTCTCAACTAGATCCTTT GGTCTGTTTGGTTAATGTATTTGAGTCATTTTTCCATAAAGCATGGTGGGATCCGTGAGCCAGATAAGAATTTGGAATTTAAGGGTTATG GTTTGCCACAGTTGACCCCAATTTGACAGAACAAAGTGCTCCTGGATGGAAGGGCAGGTTCAGCTGCAAGCATGACCCCCCACCACAAGG CTGCTGAGTTCCTCGGATTCTCACCTCCACCCACCCCAACGTGCTCTCCAACTGGAAGAGCACCCATTCATTTATAAATCAACTTTATGG AACCAATAAAATCATTTCTGTTTTAGCTGTCCCCTGGGTAAGCTATACTCTTTTACATTAACATAGCAAATGTCAACTTTTCTGTTCCTT CAAACATGGCCTTCCAGCCTGGTTGTTCCAGCATATATCCCCTCTATGTCCATGAGGCAGAACTCTCTCTTCCCCCACTCCGTTCTTCCA TCTATCCCCATCCTTTGCTGTTTCCCTGGTTCTCCAGTTCCAATTCTATTGTTTTAGTTCAGTACCTTATGTTCCCTAACAGAAATCCAG CTGCAAATGTCAACCTATTTCTTAAGCACAATTTTCTCTTGCAGGTCTAACCAAGCTAGGGCTCTGAAATGTCTATTTTTCACTGCACTC CAATTTAAAAATTATTCATGACTTCATTTAATAGTCTAAATTTTGAATTCTCCAGAGCAACATTCTTATGCTTTCCATCCCTACATTTTC TTACATTTCAGTTTTCTTACTTTTTTCCCCTTTGCTTTTTTATTTAGATTTAAGCCAGTGTCTTTGGGATATTTAGAAACTGCTTACAAA GGTGGGAACTGGTGGACAGAGAAAGGGGGCATAAGAATGCTATTAGAAAACTACCTGAACTCACCAGAAGAATGGGAAATCATTTGATTT GCTGAGAGAATACAATTAAAATACTCATAGTAAATCATTTCCAAAACAGTTTGCTAATAGTCTGGCTACTCTTCAGTCTTTCTTTCCTTG ACTTGGGTGATACTCTGTATGATTTAAAAATGTCAGGAAGGTAGTTGAAAGTTCAGTGTCCTCTATATATTGTAAACATTATCTTCAAGG ATGATTTCCTTTCAATGGATGGCTTTAACATTGAAAAACATAGGTAACATATACATAATAGATGATTCATTGATATTACTTTACAATACA CTAAAATAACATTATCTTGTTTCTGAACTTTATGGCCAACCGGTATCTAAGAAAATGTTAGCCTTTAATTTAAAATTGAGTAAAGCACGC CTCTTCCTAATATTTCTGCCTTTAATGTCTTGAGTGCTTTAGATGCAGAGTGTCATCTAGAAGTCAAAATTCTGTCAGAAGGCTGCTAAG AGATTTTGATAAATCACAGAATATATAATAATAACCCAACAATATTTTACCCAACATGGTGTGGTGTTTGAGAGCATTAAGAGCACTTGT ACAAATTATCTTATTTCATTCTAATTCACCATGAGAGGTTGAGTATTATAATTTACATTTTATAGAGGGAAAACTAGGGTTTGGGCAAAT TGGCCAAGTTTAAAGGCCAGTGAATCATAGCTCCTTGTCTCAAATCCAGGTCACAGGGCCCTAAGCTGTGGGCTATTTTTACTACAAAAA ATTTCAGCAAACCAAATCTGCTAAAAAAAAAAAAATCTGGCCTGCTGCCTGTTATTGTACCACTTGTGAGCTAAGAGCAATTTTTACATT TTTTAATAATTGGGGGAAAAAAAAGAAAAGAAGAATATTTTGAGACATGTGAAAATCATCCTAAATTCAAATTTCAATGTCCACAAACAA AGTTTTATTGGAACACAGCCACAGCCATTTGTCTGTGTATTGCCTATGGCTGCTTCCACATGCACTCACAGAGCTGAGTAATTACAACAG AGACCGTGTGGCCAGCAAAGATTGAAATATTTACTATCTGGCCCTGTATAAAAAAAGTTTGCTGACCCCTGTACTGTACTGTTAAGTACT ATTGGTACTATTAAGTACTAGTAATAGTACTATTAATAATAGTATGTAAGAGTACTAAGTACTATGAAATATTGTACTGTACTCTTAAGA GAGTCCTAGGCAATATAGAAGAATGACTTTTTTTCTAGCATAAATTATTGAAGTCACTCATAAGTCTGTTCAAAATAACATAACTCTTTT TTTTCGGTTGTCAAAGAGACAACTGCTTCACAAGACTTAGAGAGCCCAGTCATTCAGTTAGGGTCTCAAAGGAAGAATCCTTCCTTTTCA TGCCATTCCTCCAGAGTGGCAAATAGAGTCAACAGCCAGCCAGGATCTAGCGGTCAACTCAGAAAGTGGATACAGTAAAATTACTCCTTA ATGAACTACAGAGAAATGGGCATTCCCAGCCCAGCCGCTGAAATATTGCTTCAGTGGCACCCTCAGGCGTTGGATGATGTACATAGCTCA GGCTGCCAGTCTCTGCTCAGCAAAGCAGCCCAGACCTGCAGTGGTTGCCACACATCAAACCCGCCTCGCTCCTCCACATGGCTTCTCTCT TAGGCTCTCTTGGAGGAGAGTTAAATAGGTGGCCCAGATGTCTCCCTCTGTTTTCTTGCTAGTTTTCTCTAGCCTACAGTTTACAACTGA TCAAGGTGATGAACGTGAACCTGGAACTAGCTCATGTTTAATTGCGCTAGTTTTTGCTCTCTCTAGCCACTAAGCTAGAAGTTTAATGTG TAATTAAAGAACTAAATGCTTCTTATGGAAAACCAAAAGGTCCTTTGAAAAGAGCTCAGGGAGACACGGAAGTATAGTAAAGGGTTGTTG GATTTCTTGCGCTTTCTGAGTCTGAAGCAAAGACAAAGATTGGTAATTACAGACATAATGGATGGAAAAAGTCCAGACCTTGGGGTTTTT AGATGAGTCAATATTAAATGGCATTCTTTGTGTCACTAAGCTGAACTCCCTTGTCTTCTAAGGAAGCATTTCTAATGCCAGAGGTAGTCA GCCAAGCTAGGTTCCTTATCTTTTTAGTTCTATGGAAAAACATATCAAGTTCTCTTATGAGTGCTTTCCTGGAAATCAGATGAGAAAGAA AAAAAAGTAACAATGTAACAAATCATTGTGATGTTGTTATATTGTCGACAGATAAAGGATGGATTTGATCCTGCGTCTGAAACTAAGTAG GTAATGGTATCTACAATATAGATCATGCAAAAAGCTTGTGACCCTTCAACTGCATGGAAGAGTGGGAGGAAACAACTAAGTGGGAGGAAA CAAATCTCAAAGTTCAACACCATAAAACTTAAATAAATGTAAAAGGAGTCAAACTTTTACTTGGCCTCATTGCCTTGGTAAAAGAAAGCT TCATGTATCCACCTAATTCAATAAGAGAGTCCTAGGAAAAGGAAGGCAAAATACTTTAAAGGCACACAAAAATATTTCACTGGGGTGGTC AACATGATTAAGTGATGGAGATTAGATTTATCACTGATGAAAACAGTATTTATAGAGTTATTTTTAGACACTATACCCCCTAGATGCAAA TCCCAACATGCACTGTGGTTGGCCGGAGAATTGTGGCCACATAGTAAACAGATCTTGATTTCAGAGAATGAAATGTTCCTACCGACTTTG TGTAATTGCCCATTTCAAGATTAAGGCTCAGTGCCCATTGTTTTAACACCGATCATCAATACTGTGATATCAACTAAGCCAATCTTTATA AGAATATGAAGGGCTGTTTTTCTCAGGCAATGTAAATATCTGCTACCAACAAGCACTAGTGAAATAAACATGTAATCATCATCGTTTCTA AAACTCTGATAGAAATCACAAAACATTCAAGCAAAAGGGCAAGGTCTTCCAGGAGCCTAGGAGCAGACTTTTGGCTACAAAGAGCCTAGT CCAGGCTGAATGCCTTATGGAGTATGTCAGTCTTGGGTCTTATCACTAAACACAACTAGTAGAACTCGATCAACTGGAGTGCAGAGATCA GAGTTTCGGTCAGCCGTGCATTACCCAAACCTCTGGGTCTTCAGCCAGTCTTCTTAGAAGAGGGGAAGGAGCACTGTCCTCAGATCCGGC CATCACGGGCATCGCCCTGACATCATCTCTCAGCATTGCTGACTGTGGGCATGGGTATGAGAAATACCCTCCCGTAGCTCAGACTTGGGC AGAACAAAATCCTCAGCCATGCCCACCCACTGAGGTCTCTCTAGGGGAGCTTCTCCCTGCAGGGTCTGGCTCTTGCCCATCTGGACAATG ACCCCCTAGAAGTATCTTCCGGGGGACCCTGTATCTTTCAAGCTTAACTTGCCCCACACCCTTGACCCCACAGAGCACCTCCCTGGGTCA GGAATGATGACTAAATTAAGACCTTTAGCATCTGCTAAGCACAGGGGTGCCCTCCCATGTGAAAGTCCAAGTAAAATAAATGGAGTCAGG GTAAGGAAATCCCCAAAAGTTCTGATTTTCTCATGGTGATGATCTCAGTGCTTTTCTTTTTCATGACATATCTAATTCTCTTTTCTCTAG GAAGTCTCACGTTTTGGTATCACGATGCCGTGGGCACAGACTCAGTCATCGGGCCAATGGCAGAACTCTCTCCAGATAGTCTGACCTGGT CCCTCTTTTTGAGTAAGGCTGGGAGTTTGGTTTGTTTGAGCCACCCCACAACCAATAGAATCCCACCCTGGCTAAGAAATCTCACAAGGC CGGGTGCTGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCCAAGGTGGCAGATCACCTGAGGCCAGGAGTTTGAGACCAGCCTGGC CAATATGGTAATACCCCGCCTCTACTAAAAATATGAAAAAGTTAGCTGGGCATGGTAGTTCCTGCCTGTACACCCAGCTACTCTGGAGGC TGAGGCACAAGAATAGCTTAAACTTGGGAGGGGGAGGTTGCAGTAAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCCACGGAGCGAG ACTCAGTCTCAAAAAAAGAAAGAAAAGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAAAAAGATAAAGAA AGAAGGAAGGAAGGAAGGAAAGAAAGAAGGAAGGAAGGAAGAAGGAAAGAAAGAAAGAAAAGAAAGAAAGAAAAAGAAAGAAAAGAAAAG AAAAGAAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAGAAAAGAAAGAGAAAGAAAGAAAGAGAAAAGAAA TCGCACATCCCCACCTCTATCAGGGTCACCAAATGAAGGCATCAATTTCAAGTCCCGTTATTATCTGCAAGGAACTCTGCATTGCAGCAC TTACAGACACAACTTATGCTGTCTCCTGGTGCCCACACAGCTTTCGGGTGATGGCAGATTGTCAGCCAACCATTCCCCCCAGCTGCTCTC TCTTAATTTGCTCCCTCATCTCACCACGAAAACTTCACTTTTCCTGGCACCCCCGTTGGAAGGTTAATATCATTTTTGAGCATCCACAAT CCAGCAACCTATTATTGGGGTTAGTCCTATTCCTTACCACTTAATAGCCACCACCAATTTTAACCGAGCGTATATGTTCAGAGTCTAACC ATATATATATATATATATATATATATGTACATTTTGTTCCTGCTTCATAATTGCCCAGAGAGTCTATGAGTGATGGTTGGGCGTATACAT GGTCTCAGCCCGGTAACTGACGAGAGCAGCATAAAGTTAGGTCTTGTGCTGAAAGGACAGCTGGACTGGTCCAGTGGGATCTTCTTGTCC TTTGCAGCATGCCATTAGGGGACCAGCTTGCCAAAGAAGCTCCTGAACATCTTTATTCAGCCCAGTGCTTCCTCGTCTTAACCAAGAGCC ACACAGAGACAACAGTGAACTCACAAGTTCATAGGATTCCAAAATGATTGACTCCCCAAGTGTCTGCCTGTGTTGGCAAAGTGCTCTTTC CTTTCCCACTGTCTGCACAGACTGTACTCTGGGGAAACTCCCAGCACTTGTGGGTGCCTGGTTACCGAGGATGTGCTTGGCTGCCATGGT AACTCCCAGCCTCTCAGTGTGGACCACTCTCCCGCAGGCTCGAGGAGACCTGGCAGAGGCCCCATGGGGCGGAGGCTCCCTAGGGCTGCT CCACCTGCAGACAGCCTTGGGAGAACCCAAGGTAATGTGGAGTAGGACCCAGCACACAGGAGCTCCCTCCGCACGCCAGGTCTGGGGTAT TCCCATCCTTTCTTCCTAAGATGGGATGCACTTAGGTGGCCAAATTGCTTCTTAAAAGGCTCTTCTTCAAGCCATCATCCTCATATCACA CTCATGCCCACACTCCAGTCACATTTGCCTTTAAAAAATTTTCAAAATTATTTTTGTATTATCCCATGTAACAGATGTCCAAAGAGTTGC CATTTTCTTAACACTAAATAAATTCTGCCTAGAAGATTAAGATTGGTCCAGAACAGGGAGTGTTTTAATAAGCACAAATATAAACAAAAG CAATTTTAAAATTTACTTATGGATTCTTTCAGAAAACCTGATTTCAAATCAGAAATACTCATTTTTGCCCCCAGAGCAAAGTTCCAGAAT ACTATTTCTTCTTGAACTTGCCATTTTCCATCTGGCTTTGAACTTGAGAATAGACTCCCCTATATTGGCATAAAAGGTAAAGTGGAATTT ACCACTGAAACTTTCAGAGCTCAATTTAGTCTGGCCCCATGGACCAGGCAAGAATAAACTCTGCTCACCAGTAACAATTCTGCAGCCACC GTACTGAACACAAACCCTGGAGAAATTCTGGACATGGTACTGCTTAAGAATGCTGGGTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGA ACCCGGGAAGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCAGTCCGCAGTCCGACCTGGGCGACAGAGCGAGACTCCGTCTCAAAA AAAAAAAAAAAAAAAAAAAAAAGAATGCTGGGAATGTCAGTCGAGGGTCTGATTTCAGAAAGAGGACATTAATATTCAAATCCCTGAACC ATGCCCACACTGTGGGAGTCAGGCCTAACAAGATCCCAGGGTCCATAGTTTACCTGGTCAGCTTGCTGTGTCTCATGGGGCATTAGAGGG TAGATGAGAACTTTCCGCAATCTCGACAACTGCACTGTAAGAATTTCTTCTGTGTATTTTCTAATTCTGTGACAACAGGCATCAACAAAA CATGTGGCCTGTTATCACATGGTTCCTCCCTGTGTGCACCTTCATAGAGATTTTTTCCTTTTCTAAAAGAATGAGGATTCCTCTGAATGT TACACTATGCAACAATAATGTCCCCAGTCCTTCATAAGTAACACAGTAACAATATAAGCACCCTCTCCCTACATAACACACACACATACA CACAAATACACACACAGACACATGCATACACACACACATACACACAGACACATGCATACACACACATACAGAGACATGCGCATACACACA CACGCATACATGCACATGCATACACACACCAAGACATGCATACACACACGCATACACAGAGACACATGCATACACACACGTGCATACACA CACAGACATATGCATACACACACGCATACAGACATGCATACACACACATGCATACAGAGACACATGCATACACACACGCATACACACACA CGCATACACAGAGACATGCATACACACATGCATACAGAGACACATGCATACACGCACACAGACACATGCATACACACACACGCAGACACA GACACATGCATACACACAGAGATACACGCATACTCACACAGACACAGACACATGCATACGCACACACAGATATACACACACACACACACA CACACACTCTTATCCTTTCCAATCAGTTATGAGTGACACCACAAAAGTAAATTTCCAGAAATCAAAGCCTTAAGATTGGCGTTCCTCCCC TGCATGCACTGTGGCATTATTTTAAAAATGTACCATACACTTCCCTGAACCTGCAGGCAACAGCCTTTCTTCCAGTGTTTGGTAGGAACC CTGGATTCAGAAGACCAGGTTTTGCCCCCAGATGAGCAATGTCATCCTGGGTATATCATTTCACTGGTCGGAAATAGCTTCCTCCACCCC TTTTTTAAAAACTTGATAAATTTTATTTTTTAGAGCAGCATTAACTTCACAGCAAAATAGAGCAGAAATTACCAAGAGCTCTCATTTACC CCCGGCCCCCGCATGCATGGCCGCCCCCACGAGTGATATGCCAAACCACAATGGTACATCTGTGGAAATGGATGAGTCTACACTGAGACA TTACTATCACCCCAGAGTCCATTGTTTACAATGGTGTTGTACATTCTATGGATTTGGGCAAATGTATAAAGGCATGGATCCACCATTATA GAATCATACAGGATAGTCCCACGGCCCTAAAAATCCTCTGTGCTCTCCCAATTCATCTTGTGTCCTCCCAACCCCTGGCAACCACTGATC TATTTACTGTCTCCATAGTTTTGCCTTTTCCAGAATGGCATATAATTGGACTCATGCAGTACGCAGCCTTATAAAATTGGCTTATTTCAC TTAGTAACATGCATTTAAGTTTCCCTCATATCTTTTTATGGCTTGAGAGCTCACTTTTTTAGCACCAAACACTCATCCATTTTCTGGATG TACCACTGTTTATTTATCCATTCACCTACTGAAGGACACCTTGGTTGCTTCCAAGTTTGGTCAGTTATGAATAAAGCCACTATAAATATC TGTATGCAGGTTTTTGTGTGGACATAAGTTTTCAATTCATTTGGGTAAATATGATATGTTAAAGCTATATTTAGTCTTGCAAGACACAGC CAAACTGCCTTCCAAAGTGGCTGTACTGTTTTGCATTCCACTAGCGATGAATGAGGGTTCCCGTTGCTCCATATCTTCACCAGCATTTAG TGTTGTCAATGATCTGCATTTGGGCCATTCTAAAAGATGTACGGTGGTGTTTCATTGCTGTTTTAATTTGCAATTCCCTAATGACATGAT TTGGGACATATTTTTATATGCTTGTTTTCCATCTGTACATCTTCTTTGGTGAGGTGTCTGTTCAGGTCTTTTGGGCATTTTTTTAAATCG GGTTGTTTTCTTATTGTTGATTTGTTAAAGTTCTTTGTAAATTTTAGATAATAATTCTTTATCAGATGTGTCTTCTGTAAATATTTTCTC CCAGTCCGTGGCTTGTCTTCTCATTATCTTGACCTTGTCTTTTTCAGAGCAGACGCTTTTAATTTTACTGAAGTTCAGCTTATCATTTAC TTCTTTCATGATCATGTCTTTGGTGTTCTATCTAAAAATCTATTGCCATATCCAAGGTCATCTAAGTTTTCTCTTATATGTTACCTTCTA GGAGTTGTATAGTTTTGCATTTTACATTAGATCTGTGACCGATTTTGAGTTAATTTTTGTGAAAAGTGTTTGTTAGGTCTGTATTTAGAC TCTTTTTTTTTTTTTTTTTTTTGCCTGTGGATGTGCAAATGTGCAGCTATTTCAACACCGTTTGTTGAAAAGACCCTCTTTGCCGCACTG TTTTGCCTGTGCTCCTTTGCCAAGGATCAGTTAACTATATTTGTGTGGGTCTGTTTCTCAGCTCTCCATTCTGTTCCACTGATCTATTTG TCTATTCCTTCACCAACACCACATCGTCTTGAGTACTGTAGCTTTCTTTCTCCATATAAACTGCAGACTCAGTTTTTTGGTACCAACAAA ATAACTTGCTGAGATTTTTATTGGGATTGTATTTAATCTACAGAGGAAGCTGGGAAGTGACATCTTGACAATATTGAGTCCCTCCATGAA ATGGAATATCTCTGTATTTACTTAGTTCTTCTTTGATATCATTCACCAGTTTTGTAGTTTTCCTCATGTAGATCTTATACATATTGTTAG ATTTATACCTTAAGTACTTCATTTCAAGGGATACTAATTTAAATAATCATGTGCTTTTAATTTCAAATTTCACTTATTCATTGCCGGTAT ATAGGAAAACAATTGACTTTGTATATTAACTTTGAATCCTAAAATCTTGCTATAATCCCTTATTAGTTCCAGGAAGGTTCTGGGGCTTGT TTTTGTTTTGTTTTTTGGTCAGTTATTTCAGATTTTCTACATAGATGATCATGTCATCTGTAAACAAAGACAAAGTTTTATTTCTTCTTT CTTCCCAATCTATATATTTTTATTTCCTTTCCTTGTCTTATTGCATCAGCCAGGACTTCCAGTATCATGTTGAAAAGCAGTAGTGATGGG GACACCTTTTTTTTCCTGATCTTAGTGAGACAGCTTCAGGTTTCTCACCATCACGCCATTTAGTATGATGTTAGCTGTAAGGTTTTTTTT TTAGATATTGTTTATCAGGTTGAGGGGCTTCTCCTCTATTCCTGCTTTACTGAGTGTTTTTATCATGAAAGACTGTTTGGATTTTTCTGC ATCTGTTGATATGATCATGCAATTTTTCTTCTTTTGCCTGTTGATATTCATTACATTAGTTGATCTTTGAATGTTGAACCAGCCTTATAT ACCTAGGACAAATTCCACCTGGTCATGGTGTTTAATTATTTTCATATATTGTTGGACTTGATTTGCTAATATTTTGTTGAGGATTTCTGC ATCTATGCTTATGACAGGTATTGGTCTGTAGTTTTCTTGTAATGTCTTTGTCTGGTTTTGGTATTAAGGTGATGCTGGATTCATAGAATG AGTTAGCAAGTGTTCTCTCTGCTTCTAGCTTTTGAAAGAGATTGTAGATAATCAGTATCATTTCTTCCTTAAGTCTTTGGTAGAATTCAC CAGTGAACCCATCTGGGCCAAGTGCTTTCTGGTTGGGGAGGTTACTAACCATTGATTCAAATTATTTAACAGAGATATACCTATTCAGAT TGTCTATTTGCTCTTGTGTGAGTTTTGACAAATTCTATTTTTCAAGGAATTGGTTCATTTCATCTACATTATCAAATTTGTGGGTATAAA GTCATTCATAAAATTCCTTCATTATCTTTTATTATCCTTTTAACCTCCATGGGATTGCTAGTAACGTCCCCGCTCTCATTTCTGATAGTA GTAATTTGTGTTCTTTCTCTTTTTTTCTTAGTTAGCATGCCTTGAGACTTATGGAGCTTATTGATCTTTTCAAAGAATCAACTTTGTTTC TATTTATTTTATTGATTTCCTATTTTCAATTTCGTGAATTTTTAATCTAATTTTAATTATTTCTTCTCATTGGCTTACTTTGGGTTTAAT TTGCTCTTTTTTTCTACTTTTTTAAAATGGAAACTTAAATGATTGATTTCAGATCTTCTTTTGTGCTATCTGCATTCAATGTTATAAATT TCCCTTTAAGCATTGTTTTTATTGCATCCCACAAATTATAATAAGCTATGTTTTTATTTTCATTTATTTCAAAATATTTTTTCACTTATC TTGAGATTTCTTCTTTGACCCATGATATTTACACGTGTGTTGTTTAATCTCCAAGTATTTTGGCATTTTCCAGCTACCTTTCTGTTACTG ATTTCTAGCTTAATTCCATTGTTATCTAAGAGCAAACATTGTAGGACTTGTATTCCTTTTTTTTTTTTTTTTTTTTTTAAGACAGAGTCT CACTCTGTTGCCCAGGCTGGAGTAGAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTCCGGGGTTCAAGCGATTCTCCTGCCTCAGC CTCCCAAGTAGTTGGGACTACAGGTGCCCACCACCAAACCTGGCTAATTTTTGTATTTTTAATAGAGATGGGGTTTCAGCATGTTGGCCA GGCTGGTCTTGAACTCCTGATCCCAAGTGATCTGAGAATTTCTATTCTTTTAAATGTGTTAAGGTATGTTTTATGACCCAGAATGCAGTC TAACTTGATGAACATTCCATGCAAGCTTAAGCAAAAAGACTAATCTGCTGTAGTTTCCTCATCTTTTTCAACAAACATTTGAACCCCATA GTCTCTGCTTTAATAATTCTAGTATCCATTCCAACCTACACCACCATCAGTTCTAGACTGTACCTCTACACTAAATGACCCCAGATGGTT CAGCTTTAAGTCTCAGCTGTTTTCATCATTTAACTGATTCCCTTGCTGGCAGCAGGGAAATTAACTACCAGCCACACACTTGTCTCCAAC AGCACCCACCGACCACGTCCTGCTCCCCTGTCATTACCACCACTAAACCCGGTAGCAGAGAGATGAGCTGTGAGGTAGGTGCCTTCTAGA TAAATGAGGTGCTACTGGACATGCACTGTGGTCTTCTCTGCAGTAGAAAAATGTCCAAGGAAGGTCAGCATCATTGATAGAAAATAAATG TGAGGCTGCATCTCGCCAGCTCATCCATGAGCAATTCCTTCAGCTCCAGCAGGCTACTGACAATTTGCTTTTAACCCAAATCCAGCTCTA CCCTCCCTAAAGCATGCACCTAGGGCCCCAGTCAGAAAAACAAAACAAAAACTAAACCAGACAGGATAATTAAGGAGGCAAAAAGCTTAA ACCATAATATTTTAATTAAGCTGATTTATTTTAACCGTAGCACTACTGCTTTATTTTAGTTATATACCAGTAATGGAAAATAGTGGCCAC TTTTCATTATTAATCATAAGATAATTCATTGTATTTGTCTTTCCTAATAAAATGGCATTATATTAAGGCCCAAAATGTTTACTATGGCCC AGTAAAATATAGGGTTGTTCTGTGAGCTATTTCTTAGGATAGAAAATTATTCCAGAAAGCTATTAGTTCAAAAGTCTCTAGCAGTGCCAA GGTTTCAATAGTCTCTTTAATTTTGAATCTATGCGATTGAAGATAAGACTGCATCTAGTTTGGGGGTTGCATGTTTGTGGACATTCATGT TTCTATGTACCTGGAACTTCTTATTCTCACCATCACACAGAATTTTCAAGAACTAGTTAAGCAAAGAAAGCAAAGCCCAGCAGGTGTCAG AATTGGGTCCCCAAGCTGAGGGTCATTAGGGTGCATGTCAGTGTGCCAACTCCAATATCCACACCTAGAGAACGCACATCTTCCCAAAAG AAATGAAGCACAGATGATACTTGATCCTCAACTTTGTCTCCAGAAATTTTTTCAGGAACTTGAGTTCTTTATCAAATGCTCACATCCTAC AGAGAAATAAAGTGTTCCATTTTCAAGGTTCATGAAGCTCGTCAATGCTGGGAGCAGGCACACACTTGTATTTTTATACTCAGGGATCCC AACAGGCAACTAAAACTAGACAAGGACAAAACTCCACTCAAAATATTCTGAAAGTTAGCTGATGCCCCATATTTTATTACTCCAAATGTG TATTCACTTGCCTGAGTGCTGGCCATGAGCACTCAGTGAACACTTGCAGTACAGTGAGTGATGTCCTTGACAAGTTACTATGAAGACTCT GAGAAAAAGTAACATCCCCCACTGTCCTCAACAAGCCTGTAATCCCATGGCTGCCAGCCCTTACCATGCAACAACACTGCGCTAAGTGCA TCGAACCACACAAAACCCTGTGAGAAAATACTGCTTCCCACTTCACACGTGAAGTAACTGAGTCTAGTTTTAGAAATACCTAAACGAAGA GGGACAGGCACAACAAATTTGCTGGAATGTAAAGAAAGTAGATCAGTTTCTGCGTAAGCAGTAAGAAATGGCCTCATGAGGAAGAAAGGG ACATTTGCCCTGACATTTCTCAAAGACTGCTTAGGTTTTGGAGACAGAGATCCAAGGGCAGGCAAGCACAATGGTTCATGCCTGTAATTC CAGCACTTTGAGAGGCCAAGGTGGGAGGATTGCTTGAGCCCAGGAATTCAAGATTAGCCTGTGCAACACAGCAAGACCCCATCTCTATTT TAAAAAGAGAGAGAGAGATCCAAAAGCAAAGGCATTTCAGTTTGCAAGGCCAGCATGGGAGAGGGTCTTAAAACAGAAACACACAAGGTA AGATTGGGGGATGGTACCTAGACCAGCCTAGGATCATAGGATTTGATAAAATATGCATTTGGAAAACTGGTGCTAATTTATAGAGACTTA GAATTTCAGGCTAAGGACAAGGACTAAGAAACGAATAGCATGAACAGTATTATTGATAAACCCATCATTGCATCTTAAAGGCTCTGAAGT CTTTAGTATTGAATTAAAAAATAATTTTCACTGGACAAAACCAAAAGGTCTTTACACAACTGTCAAGCACTTTGAAATGATTCAGCAAAA AGCAGAATAAATCACTAGTGGAATTTCAATAGCATGTAGTTGTAAACCATCATGTGTCCAGCAAAATCACAAAACAAGAGTTTATTTTAG AAGGGACTTAGGGATATTAAGAAATATAACATACAAAATAACTAAAGTTTTCTCCAAGCAAAACCAATGATCCTTTAGGGATGAACAGAA AGAAAACAAGAAATGCTTCTTTCAAAAGTTGCTACCAAGGCTTCTAAGATTTCTTTGGAATAAAGTCACTAAGATTTGCTTCTGAGGTCA ATCTTGCCAACTTTTCCACCATGCTTTTTAGGAAGGAACACCAGGTAGGGCTCAAGTACTGGTTTGGCTCCTGTCCCATTTTTTGGTCCT TTTGTAACTCCCTTTACTCAACTCCAAGTATGTCTGTGCACGGACAATGAGACGAAAGCATGCTCAATGCGAAAGCACAAATTATGTATT GAGAAATCACTACAATGCCAAATTTTTTTAAAATAAAAAAAAAATATATATATATATATATATCTTTAAGAACTCGCTGTGTTAGGGAAA >38219_38219_2_ICOSLG-KCNJ6_ICOSLG_chr21_45649937_ENST00000344330_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=714AA_BP=299 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAG MLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVA VAIGWVCRDRCLQHSYAGAWAVSPETELTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGN VRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRV ITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSE GEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPV -------------------------------------------------------------- >38219_38219_3_ICOSLG-KCNJ6_ICOSLG_chr21_45649937_ENST00000400377_KCNJ6_chr21_39087434_ENST00000288309_length(transcript)=1943nt_BP=696nt AGAGCCTCGGGCGCGGCGGGAGCGCAGTTAGAGCCGATCTCCCGCGCCCCGAGGTTGCTCCTCTCCGAGGTCTCCCGCGGCCCAAGTTCT CCGCGCCCCGAGGTCTCCGCGCCCCGAGGTCTCCGCGGCCCGAGGTCTCCGCCCGCACCATGCGGCTGGGCAGTCCTGGACTGCTCTTCC TGCTCTTCAGCAGCCTTCGAGCTGCAAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAGCCCCTCCCAGGATGAGCTCACCTTCACGT GTACATCCATAAACGGCTACCCCAGGCCCAACGTGTACTGGATCAATAAGACGGACAACAGCCTGCTGGACCAGGCTCTGCAGAATGACA CCGTCTTCTTGAACATGCGGGGCTTGTATGACGTGGTCAGCGTGCTGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAG AGAACGTGCTTCTGCAGCAGAACCTGACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGAGAGACAAGATCACAGAGAATCCAGTCA GTACCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCTGTCCTGTGCCTGCTTGTGGTCGTGGCGGTGGCCATAGGCTGGGTGTGCA GGGACCGATGCCTCCAACACAGCTATGCAGGTGCCTGGGCTGTGAGTCCGGAGACAGAGCTCACTGCTAACGTCCTGGAGGGCGACTCCA TGGATCAGGACGTCGAAAGCCCAGTGGCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAG ATCGGACCAAAAGGAAAATCCAGAGGTACGTGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACC TGACCGATATCTTCACCACATTAGTGGACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTT TTGGAATGATCTGGTGGTTGATCGCATACATACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCA ACGGGTTCGTCTCTGCTTTTTTATTCTCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGG GAATTATTCTTCTCTTAATCCAATCTGTGTTGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCA AGAAGAGGGCAGAGACCCTGGTCTTTTCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACC TTAGGAATTCCCACATTGTGGAGGCTTCCATCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACC AGACGGATATCAACGTAGGGTATTACACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGA GTCCTTTCTGGGAGATCTCCAAAGCCCAGCTGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGA TGACATGCCAAGCTCGAAGCTCCTACATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCT ACGAAGTTGACTACAACAGCTTCCATGAGACCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGG CAGAGCTGCCCCTGAGTTGGTCTGTATCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGC >38219_38219_3_ICOSLG-KCNJ6_ICOSLG_chr21_45649937_ENST00000400377_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=598AA_BP=182 MRLGSPGLLFLLFSSLRAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIAR TPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETE LTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIF VMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMV GCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSP LIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLS -------------------------------------------------------------- >38219_38219_4_ICOSLG-KCNJ6_ICOSLG_chr21_45649937_ENST00000400377_KCNJ6_chr21_39087434_ENST00000609713_length(transcript)=19726nt_BP=696nt AGAGCCTCGGGCGCGGCGGGAGCGCAGTTAGAGCCGATCTCCCGCGCCCCGAGGTTGCTCCTCTCCGAGGTCTCCCGCGGCCCAAGTTCT CCGCGCCCCGAGGTCTCCGCGCCCCGAGGTCTCCGCGGCCCGAGGTCTCCGCCCGCACCATGCGGCTGGGCAGTCCTGGACTGCTCTTCC TGCTCTTCAGCAGCCTTCGAGCTGCAAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAGCCCCTCCCAGGATGAGCTCACCTTCACGT GTACATCCATAAACGGCTACCCCAGGCCCAACGTGTACTGGATCAATAAGACGGACAACAGCCTGCTGGACCAGGCTCTGCAGAATGACA CCGTCTTCTTGAACATGCGGGGCTTGTATGACGTGGTCAGCGTGCTGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAG AGAACGTGCTTCTGCAGCAGAACCTGACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGAGAGACAAGATCACAGAGAATCCAGTCA GTACCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCTGTCCTGTGCCTGCTTGTGGTCGTGGCGGTGGCCATAGGCTGGGTGTGCA GGGACCGATGCCTCCAACACAGCTATGCAGGTGCCTGGGCTGTGAGTCCGGAGACAGAGCTCACTGCTAACGTCCTGGAGGGCGACTCCA TGGATCAGGACGTCGAAAGCCCAGTGGCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAG ATCGGACCAAAAGGAAAATCCAGAGGTACGTGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACC TGACCGATATCTTCACCACATTAGTGGACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTT TTGGAATGATCTGGTGGTTGATCGCATACATACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCA ACGGGTTCGTCTCTGCTTTTTTATTCTCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGG GAATTATTCTTCTCTTAATCCAATCTGTGTTGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCA AGAAGAGGGCAGAGACCCTGGTCTTTTCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACC TTAGGAATTCCCACATTGTGGAGGCTTCCATCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACC AGACGGATATCAACGTAGGGTATTACACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGA GTCCTTTCTGGGAGATCTCCAAAGCCCAGCTGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGA TGACATGCCAAGCTCGAAGCTCCTACATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCT ACGAAGTTGACTACAACAGCTTCCATGAGACCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGG CAGAGCTGCCCCTGAGTTGGTCTGTATCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGC AAACAGAAAGAAATGGTGATGTGGCAAACCTGGAGAATGAATCCAAAGTTTAGTGCCCTAGCTGGGCAAACCCTTCTCTTCTCCCCCCAA CACAATCTTTCCTTGTCTCTCATTCTCTTTCTTTTTCTGTCTCTCTTGCTTTGTTCTTTATTTGTTTATATTTAATTTTTACATGACCAG AAAACAAATCTTCAAGGTGTAAAATATCTACCTGCCCTCTCTCAGTTATTCAGATTGACAAGGTAGACATGGATTTGATGAAAGTGCAAA GTGCCCTCATTTGTGGCCCAAGCCTGGTCTCCTCCCAAAATACTACACATCCAACTCCTGGAGATTTCAGTTACTTACCTGCATGTGTTG TACAATACCAGATCACTCAAAAAGGTGTGTCAAAGATTTTACCTGGGATATGACAAGCAAGGTTTCTGGTGCCTATTTATTCATTCAGTG AGACACAGAGTGGAGCCCTCAGTTTTATGGATCCCAATTCATTTCATCTACTACAGGGTGAGGTGCTTGCCCCCATGTGGGTGTGGCAGT TACAGGGCCCAGGTGAGCTGAAGACAAACCACTGTACATATATATGCCTTATGTAATTATTTTCTTTTTGTAATTAGTAATAAAACCCAG CATGTACAAAAGTACCATAGAACAGAACTGCTAAATACTGTACATAGATGTATCATTAATGTAGGTTTAGATATATAACTTTAGAAATAA GAAGCAAAAAAAAAAAGAAAGAAAGAAAGATTCCTAACATGCAGTAGGCATTTCTGTTTTGATGTCTGTGTTTTCCAGGTTATTTTGATC CAGTTGACGGCTGGCCCTTCAGTGCATGGCCTTTGTTTGTGTCTCAGACTGGCAGACGTTAGGGTACCTCACTGTTCCCACACGGATCCT TTCATTGAATCCAACAAGCCATAGGTCTGGGGGAAATTGAGAGGTCTGGTAGATGGCAAAACCCACCACCAATATGCTGATATACTGTGA AATGTTACAAAACAGATGTCTTTTTTTAAAAGATAACAAGGGCCTCACTAACTGGCCTGGAGGAGGGGGAATACCAGGAAGGAAATATTC TCTAGCCTGTCACCAAAGGTATGTTTTTACTTTTCACATGAGCTCTTGCCCTTTGTAGTACAATAATTTAGGAAACTTTTCTGCAAAACC ATTGATTCTCCAGCTGTAGTTTCTCTACACTCTTACAATGAGACATGGTAAGTTAGCAGAAGATGGTTTGGGTCTAAAGCCGTGAAATTC ACAAAGGCATGTAGTGAGTGGCATGCATTATAATCATCGACCTCTCACTTTGACTCTATCTGGCTTTCTGAGAATGACATCTCGCCTGTC CCTGGGGCTTATCCATCAGCATTTCTTGCATTGTGATCTTTTATTATTTTGAAATGACCAGAGTTCAGTATTCAAAGATTAGATCAACAA TCTTGATGATTGTCTAAGAAATGTCTCTAGAGTATGCCACAGGCTAGAAATCAAATCCAGTGTCTGTCAATCAAAAGAAAACAAATAAAA AAATTCCAGCCTTAATTCACTTTAATCTGCAAAAAGGAAAGAAGGGAGGAAGGGAGGGAGGAAGGAAGGAAGGAAGGAAGGGTATTTGTA CTGGAAATCTGAATTTTAAAATGAAAAAAATAAGGAAACAAATCTTAGATCAAACCTCCGGGGCAGGTGGAGATTTTGCACTGTTACAGA TCTTTCACATTCACTTTGCATTTATAAGCTGTTTGTTCTTTAACACAGTTGCCCATCATAAATATTCATTGAATGGATCCAAGTTTATTT TCAGCTCCTACAGCTGTGCTCAGTTTGAGGCTCTGCACCATGGAGGTCAAAGAGATCAAACTAGCTGTCCCTCTTTGTTTCCCTTGCCTT CCCTGACCTGATCGCACAGGCCTTTGGTGTAGTCTGGGGACCTTGTCTACTAAAAAAGAAGTCCCAGGATAAGGAAAGTGGCTCCTAAAT ATAACCTCGGGGCCTCTCTTCTCCCATCTCAGAGACCTTGGATCAGGACAACTGCCTCTTGGCACTGACTTTAAGGAAAACAAAACTGTT GGCTATAGCCCTTTCCTGTTTGCCAGCATTTCCTTTTTTGCATTGAATCTCTGTTGAATCATTTCTTTATTTCGCACACTCTAAGAAGGA GGTGGTGGTCCGGGAGGAGGAAGCTCGATACACTCCCCTTGAGGCTGCGGGGAGGAGCCATGGCTTGACCTCTCTGCAGCCTAATGAAGG GCACTCTTGGCTTGGGGAGCTCCCCTGCAACCTTGCCAGGGTCGCAGGGCAGGCCATGGCAGGCACAAAACAAGATGGAATAGGGGCGGC AAAATGTCTTCTAATTTAGCTCTTGAAGACTCACTGGGCCTTTTTAATTCCATTGCTAAGGTTTAAAGGACAGCGCACACCCCCGTGTCT GGTTGGAAGAGCAAGCAGCTCAGGGCCTCATCCCTGCTTGCCTGCCCTTTAGCACAACTGAACGAAGAGCCTTGACAACACGTTGGCCAC GTGCACCTGTCAGTTCTGTGTCTGTGACGGGCACCCAGATGTGAGGTCTCTCCCTGTTTCTCACTGTCTTTGTTGTCAATGTAGTTGGAG ACAGAACTTGAACCAAATCTCGTTTTTGTAATGTGAGCCTCTGAATCTTTACATGGGGATGCTCCTGAAGAACCTTTTACTAGAATGTCC CTATCAAACATGTCTATTTTTCTACAGTTGTTAACACAGTTTAACAGTGTATTTTGTGTCAACTGTTAAAATTTGGAACTGAAAGTTCAT TGAGACTGATTTTCTAAGCAGCGAGTAGTGAGTGAATGGTGTTTTCCATTAAGACAGCTCAACAAAATTGACCCCACAATTTCCACTCAT TCTATTCCGCAATATCCAGTCCTCATTCCCTCAGTCACTCCATTAGCAAACCAAGTGCAATGAGAATTTTTTAAAAGTCTCTTTTAATAC AACAGTATCCATAACTAATGAAGATCACTCTCAACTAGATCCTTTGGTCTGTTTGGTTAATGTATTTGAGTCATTTTTCCATAAAGCATG GTGGGATCCGTGAGCCAGATAAGAATTTGGAATTTAAGGGTTATGGTTTGCCACAGTTGACCCCAATTTGACAGAACAAAGTGCTCCTGG ATGGAAGGGCAGGTTCAGCTGCAAGCATGACCCCCCACCACAAGGCTGCTGAGTTCCTCGGATTCTCACCTCCACCCACCCCAACGTGCT CTCCAACTGGAAGAGCACCCATTCATTTATAAATCAACTTTATGGAACCAATAAAATCATTTCTGTTTTAGCTGTCCCCTGGGTAAGCTA TACTCTTTTACATTAACATAGCAAATGTCAACTTTTCTGTTCCTTCAAACATGGCCTTCCAGCCTGGTTGTTCCAGCATATATCCCCTCT ATGTCCATGAGGCAGAACTCTCTCTTCCCCCACTCCGTTCTTCCATCTATCCCCATCCTTTGCTGTTTCCCTGGTTCTCCAGTTCCAATT CTATTGTTTTAGTTCAGTACCTTATGTTCCCTAACAGAAATCCAGCTGCAAATGTCAACCTATTTCTTAAGCACAATTTTCTCTTGCAGG TCTAACCAAGCTAGGGCTCTGAAATGTCTATTTTTCACTGCACTCCAATTTAAAAATTATTCATGACTTCATTTAATAGTCTAAATTTTG AATTCTCCAGAGCAACATTCTTATGCTTTCCATCCCTACATTTTCTTACATTTCAGTTTTCTTACTTTTTTCCCCTTTGCTTTTTTATTT AGATTTAAGCCAGTGTCTTTGGGATATTTAGAAACTGCTTACAAAGGTGGGAACTGGTGGACAGAGAAAGGGGGCATAAGAATGCTATTA GAAAACTACCTGAACTCACCAGAAGAATGGGAAATCATTTGATTTGCTGAGAGAATACAATTAAAATACTCATAGTAAATCATTTCCAAA ACAGTTTGCTAATAGTCTGGCTACTCTTCAGTCTTTCTTTCCTTGACTTGGGTGATACTCTGTATGATTTAAAAATGTCAGGAAGGTAGT TGAAAGTTCAGTGTCCTCTATATATTGTAAACATTATCTTCAAGGATGATTTCCTTTCAATGGATGGCTTTAACATTGAAAAACATAGGT AACATATACATAATAGATGATTCATTGATATTACTTTACAATACACTAAAATAACATTATCTTGTTTCTGAACTTTATGGCCAACCGGTA TCTAAGAAAATGTTAGCCTTTAATTTAAAATTGAGTAAAGCACGCCTCTTCCTAATATTTCTGCCTTTAATGTCTTGAGTGCTTTAGATG CAGAGTGTCATCTAGAAGTCAAAATTCTGTCAGAAGGCTGCTAAGAGATTTTGATAAATCACAGAATATATAATAATAACCCAACAATAT TTTACCCAACATGGTGTGGTGTTTGAGAGCATTAAGAGCACTTGTACAAATTATCTTATTTCATTCTAATTCACCATGAGAGGTTGAGTA TTATAATTTACATTTTATAGAGGGAAAACTAGGGTTTGGGCAAATTGGCCAAGTTTAAAGGCCAGTGAATCATAGCTCCTTGTCTCAAAT CCAGGTCACAGGGCCCTAAGCTGTGGGCTATTTTTACTACAAAAAATTTCAGCAAACCAAATCTGCTAAAAAAAAAAAAATCTGGCCTGC TGCCTGTTATTGTACCACTTGTGAGCTAAGAGCAATTTTTACATTTTTTAATAATTGGGGGAAAAAAAAGAAAAGAAGAATATTTTGAGA CATGTGAAAATCATCCTAAATTCAAATTTCAATGTCCACAAACAAAGTTTTATTGGAACACAGCCACAGCCATTTGTCTGTGTATTGCCT ATGGCTGCTTCCACATGCACTCACAGAGCTGAGTAATTACAACAGAGACCGTGTGGCCAGCAAAGATTGAAATATTTACTATCTGGCCCT GTATAAAAAAAGTTTGCTGACCCCTGTACTGTACTGTTAAGTACTATTGGTACTATTAAGTACTAGTAATAGTACTATTAATAATAGTAT GTAAGAGTACTAAGTACTATGAAATATTGTACTGTACTCTTAAGAGAGTCCTAGGCAATATAGAAGAATGACTTTTTTTCTAGCATAAAT TATTGAAGTCACTCATAAGTCTGTTCAAAATAACATAACTCTTTTTTTTCGGTTGTCAAAGAGACAACTGCTTCACAAGACTTAGAGAGC CCAGTCATTCAGTTAGGGTCTCAAAGGAAGAATCCTTCCTTTTCATGCCATTCCTCCAGAGTGGCAAATAGAGTCAACAGCCAGCCAGGA TCTAGCGGTCAACTCAGAAAGTGGATACAGTAAAATTACTCCTTAATGAACTACAGAGAAATGGGCATTCCCAGCCCAGCCGCTGAAATA TTGCTTCAGTGGCACCCTCAGGCGTTGGATGATGTACATAGCTCAGGCTGCCAGTCTCTGCTCAGCAAAGCAGCCCAGACCTGCAGTGGT TGCCACACATCAAACCCGCCTCGCTCCTCCACATGGCTTCTCTCTTAGGCTCTCTTGGAGGAGAGTTAAATAGGTGGCCCAGATGTCTCC CTCTGTTTTCTTGCTAGTTTTCTCTAGCCTACAGTTTACAACTGATCAAGGTGATGAACGTGAACCTGGAACTAGCTCATGTTTAATTGC GCTAGTTTTTGCTCTCTCTAGCCACTAAGCTAGAAGTTTAATGTGTAATTAAAGAACTAAATGCTTCTTATGGAAAACCAAAAGGTCCTT TGAAAAGAGCTCAGGGAGACACGGAAGTATAGTAAAGGGTTGTTGGATTTCTTGCGCTTTCTGAGTCTGAAGCAAAGACAAAGATTGGTA ATTACAGACATAATGGATGGAAAAAGTCCAGACCTTGGGGTTTTTAGATGAGTCAATATTAAATGGCATTCTTTGTGTCACTAAGCTGAA CTCCCTTGTCTTCTAAGGAAGCATTTCTAATGCCAGAGGTAGTCAGCCAAGCTAGGTTCCTTATCTTTTTAGTTCTATGGAAAAACATAT CAAGTTCTCTTATGAGTGCTTTCCTGGAAATCAGATGAGAAAGAAAAAAAAGTAACAATGTAACAAATCATTGTGATGTTGTTATATTGT CGACAGATAAAGGATGGATTTGATCCTGCGTCTGAAACTAAGTAGGTAATGGTATCTACAATATAGATCATGCAAAAAGCTTGTGACCCT TCAACTGCATGGAAGAGTGGGAGGAAACAACTAAGTGGGAGGAAACAAATCTCAAAGTTCAACACCATAAAACTTAAATAAATGTAAAAG GAGTCAAACTTTTACTTGGCCTCATTGCCTTGGTAAAAGAAAGCTTCATGTATCCACCTAATTCAATAAGAGAGTCCTAGGAAAAGGAAG GCAAAATACTTTAAAGGCACACAAAAATATTTCACTGGGGTGGTCAACATGATTAAGTGATGGAGATTAGATTTATCACTGATGAAAACA GTATTTATAGAGTTATTTTTAGACACTATACCCCCTAGATGCAAATCCCAACATGCACTGTGGTTGGCCGGAGAATTGTGGCCACATAGT AAACAGATCTTGATTTCAGAGAATGAAATGTTCCTACCGACTTTGTGTAATTGCCCATTTCAAGATTAAGGCTCAGTGCCCATTGTTTTA ACACCGATCATCAATACTGTGATATCAACTAAGCCAATCTTTATAAGAATATGAAGGGCTGTTTTTCTCAGGCAATGTAAATATCTGCTA CCAACAAGCACTAGTGAAATAAACATGTAATCATCATCGTTTCTAAAACTCTGATAGAAATCACAAAACATTCAAGCAAAAGGGCAAGGT CTTCCAGGAGCCTAGGAGCAGACTTTTGGCTACAAAGAGCCTAGTCCAGGCTGAATGCCTTATGGAGTATGTCAGTCTTGGGTCTTATCA CTAAACACAACTAGTAGAACTCGATCAACTGGAGTGCAGAGATCAGAGTTTCGGTCAGCCGTGCATTACCCAAACCTCTGGGTCTTCAGC CAGTCTTCTTAGAAGAGGGGAAGGAGCACTGTCCTCAGATCCGGCCATCACGGGCATCGCCCTGACATCATCTCTCAGCATTGCTGACTG TGGGCATGGGTATGAGAAATACCCTCCCGTAGCTCAGACTTGGGCAGAACAAAATCCTCAGCCATGCCCACCCACTGAGGTCTCTCTAGG GGAGCTTCTCCCTGCAGGGTCTGGCTCTTGCCCATCTGGACAATGACCCCCTAGAAGTATCTTCCGGGGGACCCTGTATCTTTCAAGCTT AACTTGCCCCACACCCTTGACCCCACAGAGCACCTCCCTGGGTCAGGAATGATGACTAAATTAAGACCTTTAGCATCTGCTAAGCACAGG GGTGCCCTCCCATGTGAAAGTCCAAGTAAAATAAATGGAGTCAGGGTAAGGAAATCCCCAAAAGTTCTGATTTTCTCATGGTGATGATCT CAGTGCTTTTCTTTTTCATGACATATCTAATTCTCTTTTCTCTAGGAAGTCTCACGTTTTGGTATCACGATGCCGTGGGCACAGACTCAG TCATCGGGCCAATGGCAGAACTCTCTCCAGATAGTCTGACCTGGTCCCTCTTTTTGAGTAAGGCTGGGAGTTTGGTTTGTTTGAGCCACC CCACAACCAATAGAATCCCACCCTGGCTAAGAAATCTCACAAGGCCGGGTGCTGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCC AAGGTGGCAGATCACCTGAGGCCAGGAGTTTGAGACCAGCCTGGCCAATATGGTAATACCCCGCCTCTACTAAAAATATGAAAAAGTTAG CTGGGCATGGTAGTTCCTGCCTGTACACCCAGCTACTCTGGAGGCTGAGGCACAAGAATAGCTTAAACTTGGGAGGGGGAGGTTGCAGTA AGCTGAGATCATGCCACTGCACTCCAGCCTGGGCCACGGAGCGAGACTCAGTCTCAAAAAAAGAAAGAAAAGAAGGAAGGAAGGAAGGAA GGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAAAAAGATAAAGAAAGAAGGAAGGAAGGAAGGAAAGAAAGAAGGAAGGAAGGAAGAAGG AAAGAAAGAAAGAAAAGAAAGAAAGAAAAAGAAAGAAAAGAAAAGAAAAGAAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAA AGAAAGAAAGAGAAAAGAAAGAGAAAGAAAGAAAGAGAAAAGAAATCGCACATCCCCACCTCTATCAGGGTCACCAAATGAAGGCATCAA TTTCAAGTCCCGTTATTATCTGCAAGGAACTCTGCATTGCAGCACTTACAGACACAACTTATGCTGTCTCCTGGTGCCCACACAGCTTTC GGGTGATGGCAGATTGTCAGCCAACCATTCCCCCCAGCTGCTCTCTCTTAATTTGCTCCCTCATCTCACCACGAAAACTTCACTTTTCCT GGCACCCCCGTTGGAAGGTTAATATCATTTTTGAGCATCCACAATCCAGCAACCTATTATTGGGGTTAGTCCTATTCCTTACCACTTAAT AGCCACCACCAATTTTAACCGAGCGTATATGTTCAGAGTCTAACCATATATATATATATATATATATATATGTACATTTTGTTCCTGCTT CATAATTGCCCAGAGAGTCTATGAGTGATGGTTGGGCGTATACATGGTCTCAGCCCGGTAACTGACGAGAGCAGCATAAAGTTAGGTCTT GTGCTGAAAGGACAGCTGGACTGGTCCAGTGGGATCTTCTTGTCCTTTGCAGCATGCCATTAGGGGACCAGCTTGCCAAAGAAGCTCCTG AACATCTTTATTCAGCCCAGTGCTTCCTCGTCTTAACCAAGAGCCACACAGAGACAACAGTGAACTCACAAGTTCATAGGATTCCAAAAT GATTGACTCCCCAAGTGTCTGCCTGTGTTGGCAAAGTGCTCTTTCCTTTCCCACTGTCTGCACAGACTGTACTCTGGGGAAACTCCCAGC ACTTGTGGGTGCCTGGTTACCGAGGATGTGCTTGGCTGCCATGGTAACTCCCAGCCTCTCAGTGTGGACCACTCTCCCGCAGGCTCGAGG AGACCTGGCAGAGGCCCCATGGGGCGGAGGCTCCCTAGGGCTGCTCCACCTGCAGACAGCCTTGGGAGAACCCAAGGTAATGTGGAGTAG GACCCAGCACACAGGAGCTCCCTCCGCACGCCAGGTCTGGGGTATTCCCATCCTTTCTTCCTAAGATGGGATGCACTTAGGTGGCCAAAT TGCTTCTTAAAAGGCTCTTCTTCAAGCCATCATCCTCATATCACACTCATGCCCACACTCCAGTCACATTTGCCTTTAAAAAATTTTCAA AATTATTTTTGTATTATCCCATGTAACAGATGTCCAAAGAGTTGCCATTTTCTTAACACTAAATAAATTCTGCCTAGAAGATTAAGATTG GTCCAGAACAGGGAGTGTTTTAATAAGCACAAATATAAACAAAAGCAATTTTAAAATTTACTTATGGATTCTTTCAGAAAACCTGATTTC AAATCAGAAATACTCATTTTTGCCCCCAGAGCAAAGTTCCAGAATACTATTTCTTCTTGAACTTGCCATTTTCCATCTGGCTTTGAACTT GAGAATAGACTCCCCTATATTGGCATAAAAGGTAAAGTGGAATTTACCACTGAAACTTTCAGAGCTCAATTTAGTCTGGCCCCATGGACC AGGCAAGAATAAACTCTGCTCACCAGTAACAATTCTGCAGCCACCGTACTGAACACAAACCCTGGAGAAATTCTGGACATGGTACTGCTT AAGAATGCTGGGTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAAGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCA GTCCGCAGTCCGACCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAATGCTGGGAATGTCAGTCGAG GGTCTGATTTCAGAAAGAGGACATTAATATTCAAATCCCTGAACCATGCCCACACTGTGGGAGTCAGGCCTAACAAGATCCCAGGGTCCA TAGTTTACCTGGTCAGCTTGCTGTGTCTCATGGGGCATTAGAGGGTAGATGAGAACTTTCCGCAATCTCGACAACTGCACTGTAAGAATT TCTTCTGTGTATTTTCTAATTCTGTGACAACAGGCATCAACAAAACATGTGGCCTGTTATCACATGGTTCCTCCCTGTGTGCACCTTCAT AGAGATTTTTTCCTTTTCTAAAAGAATGAGGATTCCTCTGAATGTTACACTATGCAACAATAATGTCCCCAGTCCTTCATAAGTAACACA GTAACAATATAAGCACCCTCTCCCTACATAACACACACACATACACACAAATACACACACAGACACATGCATACACACACACATACACAC AGACACATGCATACACACACATACAGAGACATGCGCATACACACACACGCATACATGCACATGCATACACACACCAAGACATGCATACAC ACACGCATACACAGAGACACATGCATACACACACGTGCATACACACACAGACATATGCATACACACACGCATACAGACATGCATACACAC ACATGCATACAGAGACACATGCATACACACACGCATACACACACACGCATACACAGAGACATGCATACACACATGCATACAGAGACACAT GCATACACGCACACAGACACATGCATACACACACACGCAGACACAGACACATGCATACACACAGAGATACACGCATACTCACACAGACAC AGACACATGCATACGCACACACAGATATACACACACACACACACACACACACTCTTATCCTTTCCAATCAGTTATGAGTGACACCACAAA AGTAAATTTCCAGAAATCAAAGCCTTAAGATTGGCGTTCCTCCCCTGCATGCACTGTGGCATTATTTTAAAAATGTACCATACACTTCCC TGAACCTGCAGGCAACAGCCTTTCTTCCAGTGTTTGGTAGGAACCCTGGATTCAGAAGACCAGGTTTTGCCCCCAGATGAGCAATGTCAT CCTGGGTATATCATTTCACTGGTCGGAAATAGCTTCCTCCACCCCTTTTTTAAAAACTTGATAAATTTTATTTTTTAGAGCAGCATTAAC TTCACAGCAAAATAGAGCAGAAATTACCAAGAGCTCTCATTTACCCCCGGCCCCCGCATGCATGGCCGCCCCCACGAGTGATATGCCAAA CCACAATGGTACATCTGTGGAAATGGATGAGTCTACACTGAGACATTACTATCACCCCAGAGTCCATTGTTTACAATGGTGTTGTACATT CTATGGATTTGGGCAAATGTATAAAGGCATGGATCCACCATTATAGAATCATACAGGATAGTCCCACGGCCCTAAAAATCCTCTGTGCTC TCCCAATTCATCTTGTGTCCTCCCAACCCCTGGCAACCACTGATCTATTTACTGTCTCCATAGTTTTGCCTTTTCCAGAATGGCATATAA TTGGACTCATGCAGTACGCAGCCTTATAAAATTGGCTTATTTCACTTAGTAACATGCATTTAAGTTTCCCTCATATCTTTTTATGGCTTG AGAGCTCACTTTTTTAGCACCAAACACTCATCCATTTTCTGGATGTACCACTGTTTATTTATCCATTCACCTACTGAAGGACACCTTGGT TGCTTCCAAGTTTGGTCAGTTATGAATAAAGCCACTATAAATATCTGTATGCAGGTTTTTGTGTGGACATAAGTTTTCAATTCATTTGGG TAAATATGATATGTTAAAGCTATATTTAGTCTTGCAAGACACAGCCAAACTGCCTTCCAAAGTGGCTGTACTGTTTTGCATTCCACTAGC GATGAATGAGGGTTCCCGTTGCTCCATATCTTCACCAGCATTTAGTGTTGTCAATGATCTGCATTTGGGCCATTCTAAAAGATGTACGGT GGTGTTTCATTGCTGTTTTAATTTGCAATTCCCTAATGACATGATTTGGGACATATTTTTATATGCTTGTTTTCCATCTGTACATCTTCT TTGGTGAGGTGTCTGTTCAGGTCTTTTGGGCATTTTTTTAAATCGGGTTGTTTTCTTATTGTTGATTTGTTAAAGTTCTTTGTAAATTTT AGATAATAATTCTTTATCAGATGTGTCTTCTGTAAATATTTTCTCCCAGTCCGTGGCTTGTCTTCTCATTATCTTGACCTTGTCTTTTTC AGAGCAGACGCTTTTAATTTTACTGAAGTTCAGCTTATCATTTACTTCTTTCATGATCATGTCTTTGGTGTTCTATCTAAAAATCTATTG CCATATCCAAGGTCATCTAAGTTTTCTCTTATATGTTACCTTCTAGGAGTTGTATAGTTTTGCATTTTACATTAGATCTGTGACCGATTT TGAGTTAATTTTTGTGAAAAGTGTTTGTTAGGTCTGTATTTAGACTCTTTTTTTTTTTTTTTTTTTTGCCTGTGGATGTGCAAATGTGCA GCTATTTCAACACCGTTTGTTGAAAAGACCCTCTTTGCCGCACTGTTTTGCCTGTGCTCCTTTGCCAAGGATCAGTTAACTATATTTGTG TGGGTCTGTTTCTCAGCTCTCCATTCTGTTCCACTGATCTATTTGTCTATTCCTTCACCAACACCACATCGTCTTGAGTACTGTAGCTTT CTTTCTCCATATAAACTGCAGACTCAGTTTTTTGGTACCAACAAAATAACTTGCTGAGATTTTTATTGGGATTGTATTTAATCTACAGAG GAAGCTGGGAAGTGACATCTTGACAATATTGAGTCCCTCCATGAAATGGAATATCTCTGTATTTACTTAGTTCTTCTTTGATATCATTCA CCAGTTTTGTAGTTTTCCTCATGTAGATCTTATACATATTGTTAGATTTATACCTTAAGTACTTCATTTCAAGGGATACTAATTTAAATA ATCATGTGCTTTTAATTTCAAATTTCACTTATTCATTGCCGGTATATAGGAAAACAATTGACTTTGTATATTAACTTTGAATCCTAAAAT CTTGCTATAATCCCTTATTAGTTCCAGGAAGGTTCTGGGGCTTGTTTTTGTTTTGTTTTTTGGTCAGTTATTTCAGATTTTCTACATAGA TGATCATGTCATCTGTAAACAAAGACAAAGTTTTATTTCTTCTTTCTTCCCAATCTATATATTTTTATTTCCTTTCCTTGTCTTATTGCA TCAGCCAGGACTTCCAGTATCATGTTGAAAAGCAGTAGTGATGGGGACACCTTTTTTTTCCTGATCTTAGTGAGACAGCTTCAGGTTTCT CACCATCACGCCATTTAGTATGATGTTAGCTGTAAGGTTTTTTTTTTAGATATTGTTTATCAGGTTGAGGGGCTTCTCCTCTATTCCTGC TTTACTGAGTGTTTTTATCATGAAAGACTGTTTGGATTTTTCTGCATCTGTTGATATGATCATGCAATTTTTCTTCTTTTGCCTGTTGAT ATTCATTACATTAGTTGATCTTTGAATGTTGAACCAGCCTTATATACCTAGGACAAATTCCACCTGGTCATGGTGTTTAATTATTTTCAT ATATTGTTGGACTTGATTTGCTAATATTTTGTTGAGGATTTCTGCATCTATGCTTATGACAGGTATTGGTCTGTAGTTTTCTTGTAATGT CTTTGTCTGGTTTTGGTATTAAGGTGATGCTGGATTCATAGAATGAGTTAGCAAGTGTTCTCTCTGCTTCTAGCTTTTGAAAGAGATTGT AGATAATCAGTATCATTTCTTCCTTAAGTCTTTGGTAGAATTCACCAGTGAACCCATCTGGGCCAAGTGCTTTCTGGTTGGGGAGGTTAC TAACCATTGATTCAAATTATTTAACAGAGATATACCTATTCAGATTGTCTATTTGCTCTTGTGTGAGTTTTGACAAATTCTATTTTTCAA GGAATTGGTTCATTTCATCTACATTATCAAATTTGTGGGTATAAAGTCATTCATAAAATTCCTTCATTATCTTTTATTATCCTTTTAACC TCCATGGGATTGCTAGTAACGTCCCCGCTCTCATTTCTGATAGTAGTAATTTGTGTTCTTTCTCTTTTTTTCTTAGTTAGCATGCCTTGA GACTTATGGAGCTTATTGATCTTTTCAAAGAATCAACTTTGTTTCTATTTATTTTATTGATTTCCTATTTTCAATTTCGTGAATTTTTAA TCTAATTTTAATTATTTCTTCTCATTGGCTTACTTTGGGTTTAATTTGCTCTTTTTTTCTACTTTTTTAAAATGGAAACTTAAATGATTG ATTTCAGATCTTCTTTTGTGCTATCTGCATTCAATGTTATAAATTTCCCTTTAAGCATTGTTTTTATTGCATCCCACAAATTATAATAAG CTATGTTTTTATTTTCATTTATTTCAAAATATTTTTTCACTTATCTTGAGATTTCTTCTTTGACCCATGATATTTACACGTGTGTTGTTT AATCTCCAAGTATTTTGGCATTTTCCAGCTACCTTTCTGTTACTGATTTCTAGCTTAATTCCATTGTTATCTAAGAGCAAACATTGTAGG ACTTGTATTCCTTTTTTTTTTTTTTTTTTTTTTAAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTAGAGTGGCATGATCTTGGCTCA CTGCAACCTCTGCCTCCGGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGTTGGGACTACAGGTGCCCACCACCAAACCTGGCT AATTTTTGTATTTTTAATAGAGATGGGGTTTCAGCATGTTGGCCAGGCTGGTCTTGAACTCCTGATCCCAAGTGATCTGAGAATTTCTAT TCTTTTAAATGTGTTAAGGTATGTTTTATGACCCAGAATGCAGTCTAACTTGATGAACATTCCATGCAAGCTTAAGCAAAAAGACTAATC TGCTGTAGTTTCCTCATCTTTTTCAACAAACATTTGAACCCCATAGTCTCTGCTTTAATAATTCTAGTATCCATTCCAACCTACACCACC ATCAGTTCTAGACTGTACCTCTACACTAAATGACCCCAGATGGTTCAGCTTTAAGTCTCAGCTGTTTTCATCATTTAACTGATTCCCTTG CTGGCAGCAGGGAAATTAACTACCAGCCACACACTTGTCTCCAACAGCACCCACCGACCACGTCCTGCTCCCCTGTCATTACCACCACTA AACCCGGTAGCAGAGAGATGAGCTGTGAGGTAGGTGCCTTCTAGATAAATGAGGTGCTACTGGACATGCACTGTGGTCTTCTCTGCAGTA GAAAAATGTCCAAGGAAGGTCAGCATCATTGATAGAAAATAAATGTGAGGCTGCATCTCGCCAGCTCATCCATGAGCAATTCCTTCAGCT CCAGCAGGCTACTGACAATTTGCTTTTAACCCAAATCCAGCTCTACCCTCCCTAAAGCATGCACCTAGGGCCCCAGTCAGAAAAACAAAA CAAAAACTAAACCAGACAGGATAATTAAGGAGGCAAAAAGCTTAAACCATAATATTTTAATTAAGCTGATTTATTTTAACCGTAGCACTA CTGCTTTATTTTAGTTATATACCAGTAATGGAAAATAGTGGCCACTTTTCATTATTAATCATAAGATAATTCATTGTATTTGTCTTTCCT AATAAAATGGCATTATATTAAGGCCCAAAATGTTTACTATGGCCCAGTAAAATATAGGGTTGTTCTGTGAGCTATTTCTTAGGATAGAAA ATTATTCCAGAAAGCTATTAGTTCAAAAGTCTCTAGCAGTGCCAAGGTTTCAATAGTCTCTTTAATTTTGAATCTATGCGATTGAAGATA AGACTGCATCTAGTTTGGGGGTTGCATGTTTGTGGACATTCATGTTTCTATGTACCTGGAACTTCTTATTCTCACCATCACACAGAATTT TCAAGAACTAGTTAAGCAAAGAAAGCAAAGCCCAGCAGGTGTCAGAATTGGGTCCCCAAGCTGAGGGTCATTAGGGTGCATGTCAGTGTG CCAACTCCAATATCCACACCTAGAGAACGCACATCTTCCCAAAAGAAATGAAGCACAGATGATACTTGATCCTCAACTTTGTCTCCAGAA ATTTTTTCAGGAACTTGAGTTCTTTATCAAATGCTCACATCCTACAGAGAAATAAAGTGTTCCATTTTCAAGGTTCATGAAGCTCGTCAA TGCTGGGAGCAGGCACACACTTGTATTTTTATACTCAGGGATCCCAACAGGCAACTAAAACTAGACAAGGACAAAACTCCACTCAAAATA TTCTGAAAGTTAGCTGATGCCCCATATTTTATTACTCCAAATGTGTATTCACTTGCCTGAGTGCTGGCCATGAGCACTCAGTGAACACTT GCAGTACAGTGAGTGATGTCCTTGACAAGTTACTATGAAGACTCTGAGAAAAAGTAACATCCCCCACTGTCCTCAACAAGCCTGTAATCC CATGGCTGCCAGCCCTTACCATGCAACAACACTGCGCTAAGTGCATCGAACCACACAAAACCCTGTGAGAAAATACTGCTTCCCACTTCA CACGTGAAGTAACTGAGTCTAGTTTTAGAAATACCTAAACGAAGAGGGACAGGCACAACAAATTTGCTGGAATGTAAAGAAAGTAGATCA GTTTCTGCGTAAGCAGTAAGAAATGGCCTCATGAGGAAGAAAGGGACATTTGCCCTGACATTTCTCAAAGACTGCTTAGGTTTTGGAGAC AGAGATCCAAGGGCAGGCAAGCACAATGGTTCATGCCTGTAATTCCAGCACTTTGAGAGGCCAAGGTGGGAGGATTGCTTGAGCCCAGGA ATTCAAGATTAGCCTGTGCAACACAGCAAGACCCCATCTCTATTTTAAAAAGAGAGAGAGAGATCCAAAAGCAAAGGCATTTCAGTTTGC AAGGCCAGCATGGGAGAGGGTCTTAAAACAGAAACACACAAGGTAAGATTGGGGGATGGTACCTAGACCAGCCTAGGATCATAGGATTTG ATAAAATATGCATTTGGAAAACTGGTGCTAATTTATAGAGACTTAGAATTTCAGGCTAAGGACAAGGACTAAGAAACGAATAGCATGAAC AGTATTATTGATAAACCCATCATTGCATCTTAAAGGCTCTGAAGTCTTTAGTATTGAATTAAAAAATAATTTTCACTGGACAAAACCAAA AGGTCTTTACACAACTGTCAAGCACTTTGAAATGATTCAGCAAAAAGCAGAATAAATCACTAGTGGAATTTCAATAGCATGTAGTTGTAA ACCATCATGTGTCCAGCAAAATCACAAAACAAGAGTTTATTTTAGAAGGGACTTAGGGATATTAAGAAATATAACATACAAAATAACTAA AGTTTTCTCCAAGCAAAACCAATGATCCTTTAGGGATGAACAGAAAGAAAACAAGAAATGCTTCTTTCAAAAGTTGCTACCAAGGCTTCT AAGATTTCTTTGGAATAAAGTCACTAAGATTTGCTTCTGAGGTCAATCTTGCCAACTTTTCCACCATGCTTTTTAGGAAGGAACACCAGG TAGGGCTCAAGTACTGGTTTGGCTCCTGTCCCATTTTTTGGTCCTTTTGTAACTCCCTTTACTCAACTCCAAGTATGTCTGTGCACGGAC AATGAGACGAAAGCATGCTCAATGCGAAAGCACAAATTATGTATTGAGAAATCACTACAATGCCAAATTTTTTTAAAATAAAAAAAAAAT ATATATATATATATATATCTTTAAGAACTCGCTGTGTTAGGGAAACTGTTTACATATTGAGGTGTTCCTCTTTTTTTGACTGGAACAATA >38219_38219_4_ICOSLG-KCNJ6_ICOSLG_chr21_45649937_ENST00000400377_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=597AA_BP=182 MRLGSPGLLFLLFSSLRAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIAR TPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETE LTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIF VMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMV GCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSP LIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLS -------------------------------------------------------------- >38219_38219_5_ICOSLG-KCNJ6_ICOSLG_chr21_45649937_ENST00000407780_KCNJ6_chr21_39087434_ENST00000288309_length(transcript)=2273nt_BP=1026nt GCGCAGTTAGAGCCGATCTCCCGCGCCCCGAGGTTGCTCCTCTCCGAGGTCTCCCGCGGCCCAAGTTCTCCGCGCCCCGAGGTCTCCGCG CCCCGAGGTCTCCGCGGCCCGAGGTCTCCGCCCGCACCATGCGGCTGGGCAGTCCTGGACTGCTCTTCCTGCTCTTCAGCAGCCTTCGAG CTGATACTCAGGAGAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCGCTTGCCCTGAAGGAAGCCGTTTTGATTTAA ATGATGTTTACGTATATTGGCAAACCAGTGAGTCGAAAACCGTGGTGACCTACCACATCCCACAGAACAGCTCCTTGGAAAACGTGGACA GCCGCTACCGGAACCGAGCCCTGATGTCACCGGCCGGCATGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACGTCACCCCCCAGGACG AGCAGAAGTTTCACTGCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCGTTGAGGTTACACTGCATGTGGCAGCAAACT TCAGCGTGCCCGTCGTCAGCGCCCCCCACAGCCCCTCCCAGGATGAGCTCACCTTCACGTGTACATCCATAAACGGCTACCCCAGGCCCA ACGTGTACTGGATCAATAAGACGGACAACAGCCTGCTGGACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATGCGGGGCTTGTATG ACGTGGTCAGCGTGCTGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAACGTGCTTCTGCAGCAGAACCTGACTG TCGGCAGCCAGACAGGAAATGACATCGGAGAGAGAGACAAGATCACAGAGAATCCAGTCAGTACCGGCGAGAAAAACGCGGCCACGTGGA GCATCCTGGCTGTCCTGTGCCTGCTTGTGGTCGTGGCGGTGGCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACACAGCTATGCAG GTGCCTGGGCTGTGAGTCCGGAGACAGAGCTCACTGCTAACGTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTGGCCA TTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGGTACG TGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTGGACC TGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCATACA TACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTCTCAA TAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCTGTGT TGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTTTCCA CCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCTTCCA TCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTACACGG GGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCCCAGC TGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTACATCA CCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCATGAGA CCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTATCCA GCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCAAACC >38219_38219_5_ICOSLG-KCNJ6_ICOSLG_chr21_45649937_ENST00000407780_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=715AA_BP=299 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAG MLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVA VAIGWVCRDRCLQHSYAGAWAVSPETELTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGN VRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRV ITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSE GEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPV -------------------------------------------------------------- >38219_38219_6_ICOSLG-KCNJ6_ICOSLG_chr21_45649937_ENST00000407780_KCNJ6_chr21_39087434_ENST00000609713_length(transcript)=20056nt_BP=1026nt GCGCAGTTAGAGCCGATCTCCCGCGCCCCGAGGTTGCTCCTCTCCGAGGTCTCCCGCGGCCCAAGTTCTCCGCGCCCCGAGGTCTCCGCG CCCCGAGGTCTCCGCGGCCCGAGGTCTCCGCCCGCACCATGCGGCTGGGCAGTCCTGGACTGCTCTTCCTGCTCTTCAGCAGCCTTCGAG CTGATACTCAGGAGAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCGCTTGCCCTGAAGGAAGCCGTTTTGATTTAA ATGATGTTTACGTATATTGGCAAACCAGTGAGTCGAAAACCGTGGTGACCTACCACATCCCACAGAACAGCTCCTTGGAAAACGTGGACA GCCGCTACCGGAACCGAGCCCTGATGTCACCGGCCGGCATGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACGTCACCCCCCAGGACG AGCAGAAGTTTCACTGCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCGTTGAGGTTACACTGCATGTGGCAGCAAACT TCAGCGTGCCCGTCGTCAGCGCCCCCCACAGCCCCTCCCAGGATGAGCTCACCTTCACGTGTACATCCATAAACGGCTACCCCAGGCCCA ACGTGTACTGGATCAATAAGACGGACAACAGCCTGCTGGACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATGCGGGGCTTGTATG ACGTGGTCAGCGTGCTGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAACGTGCTTCTGCAGCAGAACCTGACTG TCGGCAGCCAGACAGGAAATGACATCGGAGAGAGAGACAAGATCACAGAGAATCCAGTCAGTACCGGCGAGAAAAACGCGGCCACGTGGA GCATCCTGGCTGTCCTGTGCCTGCTTGTGGTCGTGGCGGTGGCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACACAGCTATGCAG GTGCCTGGGCTGTGAGTCCGGAGACAGAGCTCACTGCTAACGTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTGGCCA TTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGGTACG TGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTGGACC TGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCATACA TACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTCTCAA TAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCTGTGT TGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTTTCCA CCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCTTCCA TCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTACACGG GGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCCCAGC TGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTACATCA CCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCATGAGA CCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTATCCA GCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCAAACC TGGAGAATGAATCCAAAGTTTAGTGCCCTAGCTGGGCAAACCCTTCTCTTCTCCCCCCAACACAATCTTTCCTTGTCTCTCATTCTCTTT CTTTTTCTGTCTCTCTTGCTTTGTTCTTTATTTGTTTATATTTAATTTTTACATGACCAGAAAACAAATCTTCAAGGTGTAAAATATCTA CCTGCCCTCTCTCAGTTATTCAGATTGACAAGGTAGACATGGATTTGATGAAAGTGCAAAGTGCCCTCATTTGTGGCCCAAGCCTGGTCT CCTCCCAAAATACTACACATCCAACTCCTGGAGATTTCAGTTACTTACCTGCATGTGTTGTACAATACCAGATCACTCAAAAAGGTGTGT CAAAGATTTTACCTGGGATATGACAAGCAAGGTTTCTGGTGCCTATTTATTCATTCAGTGAGACACAGAGTGGAGCCCTCAGTTTTATGG ATCCCAATTCATTTCATCTACTACAGGGTGAGGTGCTTGCCCCCATGTGGGTGTGGCAGTTACAGGGCCCAGGTGAGCTGAAGACAAACC ACTGTACATATATATGCCTTATGTAATTATTTTCTTTTTGTAATTAGTAATAAAACCCAGCATGTACAAAAGTACCATAGAACAGAACTG CTAAATACTGTACATAGATGTATCATTAATGTAGGTTTAGATATATAACTTTAGAAATAAGAAGCAAAAAAAAAAAGAAAGAAAGAAAGA TTCCTAACATGCAGTAGGCATTTCTGTTTTGATGTCTGTGTTTTCCAGGTTATTTTGATCCAGTTGACGGCTGGCCCTTCAGTGCATGGC CTTTGTTTGTGTCTCAGACTGGCAGACGTTAGGGTACCTCACTGTTCCCACACGGATCCTTTCATTGAATCCAACAAGCCATAGGTCTGG GGGAAATTGAGAGGTCTGGTAGATGGCAAAACCCACCACCAATATGCTGATATACTGTGAAATGTTACAAAACAGATGTCTTTTTTTAAA AGATAACAAGGGCCTCACTAACTGGCCTGGAGGAGGGGGAATACCAGGAAGGAAATATTCTCTAGCCTGTCACCAAAGGTATGTTTTTAC TTTTCACATGAGCTCTTGCCCTTTGTAGTACAATAATTTAGGAAACTTTTCTGCAAAACCATTGATTCTCCAGCTGTAGTTTCTCTACAC TCTTACAATGAGACATGGTAAGTTAGCAGAAGATGGTTTGGGTCTAAAGCCGTGAAATTCACAAAGGCATGTAGTGAGTGGCATGCATTA TAATCATCGACCTCTCACTTTGACTCTATCTGGCTTTCTGAGAATGACATCTCGCCTGTCCCTGGGGCTTATCCATCAGCATTTCTTGCA TTGTGATCTTTTATTATTTTGAAATGACCAGAGTTCAGTATTCAAAGATTAGATCAACAATCTTGATGATTGTCTAAGAAATGTCTCTAG AGTATGCCACAGGCTAGAAATCAAATCCAGTGTCTGTCAATCAAAAGAAAACAAATAAAAAAATTCCAGCCTTAATTCACTTTAATCTGC AAAAAGGAAAGAAGGGAGGAAGGGAGGGAGGAAGGAAGGAAGGAAGGAAGGGTATTTGTACTGGAAATCTGAATTTTAAAATGAAAAAAA TAAGGAAACAAATCTTAGATCAAACCTCCGGGGCAGGTGGAGATTTTGCACTGTTACAGATCTTTCACATTCACTTTGCATTTATAAGCT GTTTGTTCTTTAACACAGTTGCCCATCATAAATATTCATTGAATGGATCCAAGTTTATTTTCAGCTCCTACAGCTGTGCTCAGTTTGAGG CTCTGCACCATGGAGGTCAAAGAGATCAAACTAGCTGTCCCTCTTTGTTTCCCTTGCCTTCCCTGACCTGATCGCACAGGCCTTTGGTGT AGTCTGGGGACCTTGTCTACTAAAAAAGAAGTCCCAGGATAAGGAAAGTGGCTCCTAAATATAACCTCGGGGCCTCTCTTCTCCCATCTC AGAGACCTTGGATCAGGACAACTGCCTCTTGGCACTGACTTTAAGGAAAACAAAACTGTTGGCTATAGCCCTTTCCTGTTTGCCAGCATT TCCTTTTTTGCATTGAATCTCTGTTGAATCATTTCTTTATTTCGCACACTCTAAGAAGGAGGTGGTGGTCCGGGAGGAGGAAGCTCGATA CACTCCCCTTGAGGCTGCGGGGAGGAGCCATGGCTTGACCTCTCTGCAGCCTAATGAAGGGCACTCTTGGCTTGGGGAGCTCCCCTGCAA CCTTGCCAGGGTCGCAGGGCAGGCCATGGCAGGCACAAAACAAGATGGAATAGGGGCGGCAAAATGTCTTCTAATTTAGCTCTTGAAGAC TCACTGGGCCTTTTTAATTCCATTGCTAAGGTTTAAAGGACAGCGCACACCCCCGTGTCTGGTTGGAAGAGCAAGCAGCTCAGGGCCTCA TCCCTGCTTGCCTGCCCTTTAGCACAACTGAACGAAGAGCCTTGACAACACGTTGGCCACGTGCACCTGTCAGTTCTGTGTCTGTGACGG GCACCCAGATGTGAGGTCTCTCCCTGTTTCTCACTGTCTTTGTTGTCAATGTAGTTGGAGACAGAACTTGAACCAAATCTCGTTTTTGTA ATGTGAGCCTCTGAATCTTTACATGGGGATGCTCCTGAAGAACCTTTTACTAGAATGTCCCTATCAAACATGTCTATTTTTCTACAGTTG TTAACACAGTTTAACAGTGTATTTTGTGTCAACTGTTAAAATTTGGAACTGAAAGTTCATTGAGACTGATTTTCTAAGCAGCGAGTAGTG AGTGAATGGTGTTTTCCATTAAGACAGCTCAACAAAATTGACCCCACAATTTCCACTCATTCTATTCCGCAATATCCAGTCCTCATTCCC TCAGTCACTCCATTAGCAAACCAAGTGCAATGAGAATTTTTTAAAAGTCTCTTTTAATACAACAGTATCCATAACTAATGAAGATCACTC TCAACTAGATCCTTTGGTCTGTTTGGTTAATGTATTTGAGTCATTTTTCCATAAAGCATGGTGGGATCCGTGAGCCAGATAAGAATTTGG AATTTAAGGGTTATGGTTTGCCACAGTTGACCCCAATTTGACAGAACAAAGTGCTCCTGGATGGAAGGGCAGGTTCAGCTGCAAGCATGA CCCCCCACCACAAGGCTGCTGAGTTCCTCGGATTCTCACCTCCACCCACCCCAACGTGCTCTCCAACTGGAAGAGCACCCATTCATTTAT AAATCAACTTTATGGAACCAATAAAATCATTTCTGTTTTAGCTGTCCCCTGGGTAAGCTATACTCTTTTACATTAACATAGCAAATGTCA ACTTTTCTGTTCCTTCAAACATGGCCTTCCAGCCTGGTTGTTCCAGCATATATCCCCTCTATGTCCATGAGGCAGAACTCTCTCTTCCCC CACTCCGTTCTTCCATCTATCCCCATCCTTTGCTGTTTCCCTGGTTCTCCAGTTCCAATTCTATTGTTTTAGTTCAGTACCTTATGTTCC CTAACAGAAATCCAGCTGCAAATGTCAACCTATTTCTTAAGCACAATTTTCTCTTGCAGGTCTAACCAAGCTAGGGCTCTGAAATGTCTA TTTTTCACTGCACTCCAATTTAAAAATTATTCATGACTTCATTTAATAGTCTAAATTTTGAATTCTCCAGAGCAACATTCTTATGCTTTC CATCCCTACATTTTCTTACATTTCAGTTTTCTTACTTTTTTCCCCTTTGCTTTTTTATTTAGATTTAAGCCAGTGTCTTTGGGATATTTA GAAACTGCTTACAAAGGTGGGAACTGGTGGACAGAGAAAGGGGGCATAAGAATGCTATTAGAAAACTACCTGAACTCACCAGAAGAATGG GAAATCATTTGATTTGCTGAGAGAATACAATTAAAATACTCATAGTAAATCATTTCCAAAACAGTTTGCTAATAGTCTGGCTACTCTTCA GTCTTTCTTTCCTTGACTTGGGTGATACTCTGTATGATTTAAAAATGTCAGGAAGGTAGTTGAAAGTTCAGTGTCCTCTATATATTGTAA ACATTATCTTCAAGGATGATTTCCTTTCAATGGATGGCTTTAACATTGAAAAACATAGGTAACATATACATAATAGATGATTCATTGATA TTACTTTACAATACACTAAAATAACATTATCTTGTTTCTGAACTTTATGGCCAACCGGTATCTAAGAAAATGTTAGCCTTTAATTTAAAA TTGAGTAAAGCACGCCTCTTCCTAATATTTCTGCCTTTAATGTCTTGAGTGCTTTAGATGCAGAGTGTCATCTAGAAGTCAAAATTCTGT CAGAAGGCTGCTAAGAGATTTTGATAAATCACAGAATATATAATAATAACCCAACAATATTTTACCCAACATGGTGTGGTGTTTGAGAGC ATTAAGAGCACTTGTACAAATTATCTTATTTCATTCTAATTCACCATGAGAGGTTGAGTATTATAATTTACATTTTATAGAGGGAAAACT AGGGTTTGGGCAAATTGGCCAAGTTTAAAGGCCAGTGAATCATAGCTCCTTGTCTCAAATCCAGGTCACAGGGCCCTAAGCTGTGGGCTA TTTTTACTACAAAAAATTTCAGCAAACCAAATCTGCTAAAAAAAAAAAAATCTGGCCTGCTGCCTGTTATTGTACCACTTGTGAGCTAAG AGCAATTTTTACATTTTTTAATAATTGGGGGAAAAAAAAGAAAAGAAGAATATTTTGAGACATGTGAAAATCATCCTAAATTCAAATTTC AATGTCCACAAACAAAGTTTTATTGGAACACAGCCACAGCCATTTGTCTGTGTATTGCCTATGGCTGCTTCCACATGCACTCACAGAGCT GAGTAATTACAACAGAGACCGTGTGGCCAGCAAAGATTGAAATATTTACTATCTGGCCCTGTATAAAAAAAGTTTGCTGACCCCTGTACT GTACTGTTAAGTACTATTGGTACTATTAAGTACTAGTAATAGTACTATTAATAATAGTATGTAAGAGTACTAAGTACTATGAAATATTGT ACTGTACTCTTAAGAGAGTCCTAGGCAATATAGAAGAATGACTTTTTTTCTAGCATAAATTATTGAAGTCACTCATAAGTCTGTTCAAAA TAACATAACTCTTTTTTTTCGGTTGTCAAAGAGACAACTGCTTCACAAGACTTAGAGAGCCCAGTCATTCAGTTAGGGTCTCAAAGGAAG AATCCTTCCTTTTCATGCCATTCCTCCAGAGTGGCAAATAGAGTCAACAGCCAGCCAGGATCTAGCGGTCAACTCAGAAAGTGGATACAG TAAAATTACTCCTTAATGAACTACAGAGAAATGGGCATTCCCAGCCCAGCCGCTGAAATATTGCTTCAGTGGCACCCTCAGGCGTTGGAT GATGTACATAGCTCAGGCTGCCAGTCTCTGCTCAGCAAAGCAGCCCAGACCTGCAGTGGTTGCCACACATCAAACCCGCCTCGCTCCTCC ACATGGCTTCTCTCTTAGGCTCTCTTGGAGGAGAGTTAAATAGGTGGCCCAGATGTCTCCCTCTGTTTTCTTGCTAGTTTTCTCTAGCCT ACAGTTTACAACTGATCAAGGTGATGAACGTGAACCTGGAACTAGCTCATGTTTAATTGCGCTAGTTTTTGCTCTCTCTAGCCACTAAGC TAGAAGTTTAATGTGTAATTAAAGAACTAAATGCTTCTTATGGAAAACCAAAAGGTCCTTTGAAAAGAGCTCAGGGAGACACGGAAGTAT AGTAAAGGGTTGTTGGATTTCTTGCGCTTTCTGAGTCTGAAGCAAAGACAAAGATTGGTAATTACAGACATAATGGATGGAAAAAGTCCA GACCTTGGGGTTTTTAGATGAGTCAATATTAAATGGCATTCTTTGTGTCACTAAGCTGAACTCCCTTGTCTTCTAAGGAAGCATTTCTAA TGCCAGAGGTAGTCAGCCAAGCTAGGTTCCTTATCTTTTTAGTTCTATGGAAAAACATATCAAGTTCTCTTATGAGTGCTTTCCTGGAAA TCAGATGAGAAAGAAAAAAAAGTAACAATGTAACAAATCATTGTGATGTTGTTATATTGTCGACAGATAAAGGATGGATTTGATCCTGCG TCTGAAACTAAGTAGGTAATGGTATCTACAATATAGATCATGCAAAAAGCTTGTGACCCTTCAACTGCATGGAAGAGTGGGAGGAAACAA CTAAGTGGGAGGAAACAAATCTCAAAGTTCAACACCATAAAACTTAAATAAATGTAAAAGGAGTCAAACTTTTACTTGGCCTCATTGCCT TGGTAAAAGAAAGCTTCATGTATCCACCTAATTCAATAAGAGAGTCCTAGGAAAAGGAAGGCAAAATACTTTAAAGGCACACAAAAATAT TTCACTGGGGTGGTCAACATGATTAAGTGATGGAGATTAGATTTATCACTGATGAAAACAGTATTTATAGAGTTATTTTTAGACACTATA CCCCCTAGATGCAAATCCCAACATGCACTGTGGTTGGCCGGAGAATTGTGGCCACATAGTAAACAGATCTTGATTTCAGAGAATGAAATG TTCCTACCGACTTTGTGTAATTGCCCATTTCAAGATTAAGGCTCAGTGCCCATTGTTTTAACACCGATCATCAATACTGTGATATCAACT AAGCCAATCTTTATAAGAATATGAAGGGCTGTTTTTCTCAGGCAATGTAAATATCTGCTACCAACAAGCACTAGTGAAATAAACATGTAA TCATCATCGTTTCTAAAACTCTGATAGAAATCACAAAACATTCAAGCAAAAGGGCAAGGTCTTCCAGGAGCCTAGGAGCAGACTTTTGGC TACAAAGAGCCTAGTCCAGGCTGAATGCCTTATGGAGTATGTCAGTCTTGGGTCTTATCACTAAACACAACTAGTAGAACTCGATCAACT GGAGTGCAGAGATCAGAGTTTCGGTCAGCCGTGCATTACCCAAACCTCTGGGTCTTCAGCCAGTCTTCTTAGAAGAGGGGAAGGAGCACT GTCCTCAGATCCGGCCATCACGGGCATCGCCCTGACATCATCTCTCAGCATTGCTGACTGTGGGCATGGGTATGAGAAATACCCTCCCGT AGCTCAGACTTGGGCAGAACAAAATCCTCAGCCATGCCCACCCACTGAGGTCTCTCTAGGGGAGCTTCTCCCTGCAGGGTCTGGCTCTTG CCCATCTGGACAATGACCCCCTAGAAGTATCTTCCGGGGGACCCTGTATCTTTCAAGCTTAACTTGCCCCACACCCTTGACCCCACAGAG CACCTCCCTGGGTCAGGAATGATGACTAAATTAAGACCTTTAGCATCTGCTAAGCACAGGGGTGCCCTCCCATGTGAAAGTCCAAGTAAA ATAAATGGAGTCAGGGTAAGGAAATCCCCAAAAGTTCTGATTTTCTCATGGTGATGATCTCAGTGCTTTTCTTTTTCATGACATATCTAA TTCTCTTTTCTCTAGGAAGTCTCACGTTTTGGTATCACGATGCCGTGGGCACAGACTCAGTCATCGGGCCAATGGCAGAACTCTCTCCAG ATAGTCTGACCTGGTCCCTCTTTTTGAGTAAGGCTGGGAGTTTGGTTTGTTTGAGCCACCCCACAACCAATAGAATCCCACCCTGGCTAA GAAATCTCACAAGGCCGGGTGCTGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCCAAGGTGGCAGATCACCTGAGGCCAGGAGTT TGAGACCAGCCTGGCCAATATGGTAATACCCCGCCTCTACTAAAAATATGAAAAAGTTAGCTGGGCATGGTAGTTCCTGCCTGTACACCC AGCTACTCTGGAGGCTGAGGCACAAGAATAGCTTAAACTTGGGAGGGGGAGGTTGCAGTAAGCTGAGATCATGCCACTGCACTCCAGCCT GGGCCACGGAGCGAGACTCAGTCTCAAAAAAAGAAAGAAAAGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGG AAAAAAGATAAAGAAAGAAGGAAGGAAGGAAGGAAAGAAAGAAGGAAGGAAGGAAGAAGGAAAGAAAGAAAGAAAAGAAAGAAAGAAAAA GAAAGAAAAGAAAAGAAAAGAAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAGAAAAGAAAGAGAAAGAAA GAAAGAGAAAAGAAATCGCACATCCCCACCTCTATCAGGGTCACCAAATGAAGGCATCAATTTCAAGTCCCGTTATTATCTGCAAGGAAC TCTGCATTGCAGCACTTACAGACACAACTTATGCTGTCTCCTGGTGCCCACACAGCTTTCGGGTGATGGCAGATTGTCAGCCAACCATTC CCCCCAGCTGCTCTCTCTTAATTTGCTCCCTCATCTCACCACGAAAACTTCACTTTTCCTGGCACCCCCGTTGGAAGGTTAATATCATTT TTGAGCATCCACAATCCAGCAACCTATTATTGGGGTTAGTCCTATTCCTTACCACTTAATAGCCACCACCAATTTTAACCGAGCGTATAT GTTCAGAGTCTAACCATATATATATATATATATATATATATGTACATTTTGTTCCTGCTTCATAATTGCCCAGAGAGTCTATGAGTGATG GTTGGGCGTATACATGGTCTCAGCCCGGTAACTGACGAGAGCAGCATAAAGTTAGGTCTTGTGCTGAAAGGACAGCTGGACTGGTCCAGT GGGATCTTCTTGTCCTTTGCAGCATGCCATTAGGGGACCAGCTTGCCAAAGAAGCTCCTGAACATCTTTATTCAGCCCAGTGCTTCCTCG TCTTAACCAAGAGCCACACAGAGACAACAGTGAACTCACAAGTTCATAGGATTCCAAAATGATTGACTCCCCAAGTGTCTGCCTGTGTTG GCAAAGTGCTCTTTCCTTTCCCACTGTCTGCACAGACTGTACTCTGGGGAAACTCCCAGCACTTGTGGGTGCCTGGTTACCGAGGATGTG CTTGGCTGCCATGGTAACTCCCAGCCTCTCAGTGTGGACCACTCTCCCGCAGGCTCGAGGAGACCTGGCAGAGGCCCCATGGGGCGGAGG CTCCCTAGGGCTGCTCCACCTGCAGACAGCCTTGGGAGAACCCAAGGTAATGTGGAGTAGGACCCAGCACACAGGAGCTCCCTCCGCACG CCAGGTCTGGGGTATTCCCATCCTTTCTTCCTAAGATGGGATGCACTTAGGTGGCCAAATTGCTTCTTAAAAGGCTCTTCTTCAAGCCAT CATCCTCATATCACACTCATGCCCACACTCCAGTCACATTTGCCTTTAAAAAATTTTCAAAATTATTTTTGTATTATCCCATGTAACAGA TGTCCAAAGAGTTGCCATTTTCTTAACACTAAATAAATTCTGCCTAGAAGATTAAGATTGGTCCAGAACAGGGAGTGTTTTAATAAGCAC AAATATAAACAAAAGCAATTTTAAAATTTACTTATGGATTCTTTCAGAAAACCTGATTTCAAATCAGAAATACTCATTTTTGCCCCCAGA GCAAAGTTCCAGAATACTATTTCTTCTTGAACTTGCCATTTTCCATCTGGCTTTGAACTTGAGAATAGACTCCCCTATATTGGCATAAAA GGTAAAGTGGAATTTACCACTGAAACTTTCAGAGCTCAATTTAGTCTGGCCCCATGGACCAGGCAAGAATAAACTCTGCTCACCAGTAAC AATTCTGCAGCCACCGTACTGAACACAAACCCTGGAGAAATTCTGGACATGGTACTGCTTAAGAATGCTGGGTACTCGGGAGGCTGAGGC AGGAGAATGGCGTGAACCCGGGAAGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCAGTCCGCAGTCCGACCTGGGCGACAGAGCGA GACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAATGCTGGGAATGTCAGTCGAGGGTCTGATTTCAGAAAGAGGACATTAATAT TCAAATCCCTGAACCATGCCCACACTGTGGGAGTCAGGCCTAACAAGATCCCAGGGTCCATAGTTTACCTGGTCAGCTTGCTGTGTCTCA TGGGGCATTAGAGGGTAGATGAGAACTTTCCGCAATCTCGACAACTGCACTGTAAGAATTTCTTCTGTGTATTTTCTAATTCTGTGACAA CAGGCATCAACAAAACATGTGGCCTGTTATCACATGGTTCCTCCCTGTGTGCACCTTCATAGAGATTTTTTCCTTTTCTAAAAGAATGAG GATTCCTCTGAATGTTACACTATGCAACAATAATGTCCCCAGTCCTTCATAAGTAACACAGTAACAATATAAGCACCCTCTCCCTACATA ACACACACACATACACACAAATACACACACAGACACATGCATACACACACACATACACACAGACACATGCATACACACACATACAGAGAC ATGCGCATACACACACACGCATACATGCACATGCATACACACACCAAGACATGCATACACACACGCATACACAGAGACACATGCATACAC ACACGTGCATACACACACAGACATATGCATACACACACGCATACAGACATGCATACACACACATGCATACAGAGACACATGCATACACAC ACGCATACACACACACGCATACACAGAGACATGCATACACACATGCATACAGAGACACATGCATACACGCACACAGACACATGCATACAC ACACACGCAGACACAGACACATGCATACACACAGAGATACACGCATACTCACACAGACACAGACACATGCATACGCACACACAGATATAC ACACACACACACACACACACACTCTTATCCTTTCCAATCAGTTATGAGTGACACCACAAAAGTAAATTTCCAGAAATCAAAGCCTTAAGA TTGGCGTTCCTCCCCTGCATGCACTGTGGCATTATTTTAAAAATGTACCATACACTTCCCTGAACCTGCAGGCAACAGCCTTTCTTCCAG TGTTTGGTAGGAACCCTGGATTCAGAAGACCAGGTTTTGCCCCCAGATGAGCAATGTCATCCTGGGTATATCATTTCACTGGTCGGAAAT AGCTTCCTCCACCCCTTTTTTAAAAACTTGATAAATTTTATTTTTTAGAGCAGCATTAACTTCACAGCAAAATAGAGCAGAAATTACCAA GAGCTCTCATTTACCCCCGGCCCCCGCATGCATGGCCGCCCCCACGAGTGATATGCCAAACCACAATGGTACATCTGTGGAAATGGATGA GTCTACACTGAGACATTACTATCACCCCAGAGTCCATTGTTTACAATGGTGTTGTACATTCTATGGATTTGGGCAAATGTATAAAGGCAT GGATCCACCATTATAGAATCATACAGGATAGTCCCACGGCCCTAAAAATCCTCTGTGCTCTCCCAATTCATCTTGTGTCCTCCCAACCCC TGGCAACCACTGATCTATTTACTGTCTCCATAGTTTTGCCTTTTCCAGAATGGCATATAATTGGACTCATGCAGTACGCAGCCTTATAAA ATTGGCTTATTTCACTTAGTAACATGCATTTAAGTTTCCCTCATATCTTTTTATGGCTTGAGAGCTCACTTTTTTAGCACCAAACACTCA TCCATTTTCTGGATGTACCACTGTTTATTTATCCATTCACCTACTGAAGGACACCTTGGTTGCTTCCAAGTTTGGTCAGTTATGAATAAA GCCACTATAAATATCTGTATGCAGGTTTTTGTGTGGACATAAGTTTTCAATTCATTTGGGTAAATATGATATGTTAAAGCTATATTTAGT CTTGCAAGACACAGCCAAACTGCCTTCCAAAGTGGCTGTACTGTTTTGCATTCCACTAGCGATGAATGAGGGTTCCCGTTGCTCCATATC TTCACCAGCATTTAGTGTTGTCAATGATCTGCATTTGGGCCATTCTAAAAGATGTACGGTGGTGTTTCATTGCTGTTTTAATTTGCAATT CCCTAATGACATGATTTGGGACATATTTTTATATGCTTGTTTTCCATCTGTACATCTTCTTTGGTGAGGTGTCTGTTCAGGTCTTTTGGG CATTTTTTTAAATCGGGTTGTTTTCTTATTGTTGATTTGTTAAAGTTCTTTGTAAATTTTAGATAATAATTCTTTATCAGATGTGTCTTC TGTAAATATTTTCTCCCAGTCCGTGGCTTGTCTTCTCATTATCTTGACCTTGTCTTTTTCAGAGCAGACGCTTTTAATTTTACTGAAGTT CAGCTTATCATTTACTTCTTTCATGATCATGTCTTTGGTGTTCTATCTAAAAATCTATTGCCATATCCAAGGTCATCTAAGTTTTCTCTT ATATGTTACCTTCTAGGAGTTGTATAGTTTTGCATTTTACATTAGATCTGTGACCGATTTTGAGTTAATTTTTGTGAAAAGTGTTTGTTA GGTCTGTATTTAGACTCTTTTTTTTTTTTTTTTTTTTGCCTGTGGATGTGCAAATGTGCAGCTATTTCAACACCGTTTGTTGAAAAGACC CTCTTTGCCGCACTGTTTTGCCTGTGCTCCTTTGCCAAGGATCAGTTAACTATATTTGTGTGGGTCTGTTTCTCAGCTCTCCATTCTGTT CCACTGATCTATTTGTCTATTCCTTCACCAACACCACATCGTCTTGAGTACTGTAGCTTTCTTTCTCCATATAAACTGCAGACTCAGTTT TTTGGTACCAACAAAATAACTTGCTGAGATTTTTATTGGGATTGTATTTAATCTACAGAGGAAGCTGGGAAGTGACATCTTGACAATATT GAGTCCCTCCATGAAATGGAATATCTCTGTATTTACTTAGTTCTTCTTTGATATCATTCACCAGTTTTGTAGTTTTCCTCATGTAGATCT TATACATATTGTTAGATTTATACCTTAAGTACTTCATTTCAAGGGATACTAATTTAAATAATCATGTGCTTTTAATTTCAAATTTCACTT ATTCATTGCCGGTATATAGGAAAACAATTGACTTTGTATATTAACTTTGAATCCTAAAATCTTGCTATAATCCCTTATTAGTTCCAGGAA GGTTCTGGGGCTTGTTTTTGTTTTGTTTTTTGGTCAGTTATTTCAGATTTTCTACATAGATGATCATGTCATCTGTAAACAAAGACAAAG TTTTATTTCTTCTTTCTTCCCAATCTATATATTTTTATTTCCTTTCCTTGTCTTATTGCATCAGCCAGGACTTCCAGTATCATGTTGAAA AGCAGTAGTGATGGGGACACCTTTTTTTTCCTGATCTTAGTGAGACAGCTTCAGGTTTCTCACCATCACGCCATTTAGTATGATGTTAGC TGTAAGGTTTTTTTTTTAGATATTGTTTATCAGGTTGAGGGGCTTCTCCTCTATTCCTGCTTTACTGAGTGTTTTTATCATGAAAGACTG TTTGGATTTTTCTGCATCTGTTGATATGATCATGCAATTTTTCTTCTTTTGCCTGTTGATATTCATTACATTAGTTGATCTTTGAATGTT GAACCAGCCTTATATACCTAGGACAAATTCCACCTGGTCATGGTGTTTAATTATTTTCATATATTGTTGGACTTGATTTGCTAATATTTT GTTGAGGATTTCTGCATCTATGCTTATGACAGGTATTGGTCTGTAGTTTTCTTGTAATGTCTTTGTCTGGTTTTGGTATTAAGGTGATGC TGGATTCATAGAATGAGTTAGCAAGTGTTCTCTCTGCTTCTAGCTTTTGAAAGAGATTGTAGATAATCAGTATCATTTCTTCCTTAAGTC TTTGGTAGAATTCACCAGTGAACCCATCTGGGCCAAGTGCTTTCTGGTTGGGGAGGTTACTAACCATTGATTCAAATTATTTAACAGAGA TATACCTATTCAGATTGTCTATTTGCTCTTGTGTGAGTTTTGACAAATTCTATTTTTCAAGGAATTGGTTCATTTCATCTACATTATCAA ATTTGTGGGTATAAAGTCATTCATAAAATTCCTTCATTATCTTTTATTATCCTTTTAACCTCCATGGGATTGCTAGTAACGTCCCCGCTC TCATTTCTGATAGTAGTAATTTGTGTTCTTTCTCTTTTTTTCTTAGTTAGCATGCCTTGAGACTTATGGAGCTTATTGATCTTTTCAAAG AATCAACTTTGTTTCTATTTATTTTATTGATTTCCTATTTTCAATTTCGTGAATTTTTAATCTAATTTTAATTATTTCTTCTCATTGGCT TACTTTGGGTTTAATTTGCTCTTTTTTTCTACTTTTTTAAAATGGAAACTTAAATGATTGATTTCAGATCTTCTTTTGTGCTATCTGCAT TCAATGTTATAAATTTCCCTTTAAGCATTGTTTTTATTGCATCCCACAAATTATAATAAGCTATGTTTTTATTTTCATTTATTTCAAAAT ATTTTTTCACTTATCTTGAGATTTCTTCTTTGACCCATGATATTTACACGTGTGTTGTTTAATCTCCAAGTATTTTGGCATTTTCCAGCT ACCTTTCTGTTACTGATTTCTAGCTTAATTCCATTGTTATCTAAGAGCAAACATTGTAGGACTTGTATTCCTTTTTTTTTTTTTTTTTTT TTTAAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTAGAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTCCGGGGTTCAAGCGA TTCTCCTGCCTCAGCCTCCCAAGTAGTTGGGACTACAGGTGCCCACCACCAAACCTGGCTAATTTTTGTATTTTTAATAGAGATGGGGTT TCAGCATGTTGGCCAGGCTGGTCTTGAACTCCTGATCCCAAGTGATCTGAGAATTTCTATTCTTTTAAATGTGTTAAGGTATGTTTTATG ACCCAGAATGCAGTCTAACTTGATGAACATTCCATGCAAGCTTAAGCAAAAAGACTAATCTGCTGTAGTTTCCTCATCTTTTTCAACAAA CATTTGAACCCCATAGTCTCTGCTTTAATAATTCTAGTATCCATTCCAACCTACACCACCATCAGTTCTAGACTGTACCTCTACACTAAA TGACCCCAGATGGTTCAGCTTTAAGTCTCAGCTGTTTTCATCATTTAACTGATTCCCTTGCTGGCAGCAGGGAAATTAACTACCAGCCAC ACACTTGTCTCCAACAGCACCCACCGACCACGTCCTGCTCCCCTGTCATTACCACCACTAAACCCGGTAGCAGAGAGATGAGCTGTGAGG TAGGTGCCTTCTAGATAAATGAGGTGCTACTGGACATGCACTGTGGTCTTCTCTGCAGTAGAAAAATGTCCAAGGAAGGTCAGCATCATT GATAGAAAATAAATGTGAGGCTGCATCTCGCCAGCTCATCCATGAGCAATTCCTTCAGCTCCAGCAGGCTACTGACAATTTGCTTTTAAC CCAAATCCAGCTCTACCCTCCCTAAAGCATGCACCTAGGGCCCCAGTCAGAAAAACAAAACAAAAACTAAACCAGACAGGATAATTAAGG AGGCAAAAAGCTTAAACCATAATATTTTAATTAAGCTGATTTATTTTAACCGTAGCACTACTGCTTTATTTTAGTTATATACCAGTAATG GAAAATAGTGGCCACTTTTCATTATTAATCATAAGATAATTCATTGTATTTGTCTTTCCTAATAAAATGGCATTATATTAAGGCCCAAAA TGTTTACTATGGCCCAGTAAAATATAGGGTTGTTCTGTGAGCTATTTCTTAGGATAGAAAATTATTCCAGAAAGCTATTAGTTCAAAAGT CTCTAGCAGTGCCAAGGTTTCAATAGTCTCTTTAATTTTGAATCTATGCGATTGAAGATAAGACTGCATCTAGTTTGGGGGTTGCATGTT TGTGGACATTCATGTTTCTATGTACCTGGAACTTCTTATTCTCACCATCACACAGAATTTTCAAGAACTAGTTAAGCAAAGAAAGCAAAG CCCAGCAGGTGTCAGAATTGGGTCCCCAAGCTGAGGGTCATTAGGGTGCATGTCAGTGTGCCAACTCCAATATCCACACCTAGAGAACGC ACATCTTCCCAAAAGAAATGAAGCACAGATGATACTTGATCCTCAACTTTGTCTCCAGAAATTTTTTCAGGAACTTGAGTTCTTTATCAA ATGCTCACATCCTACAGAGAAATAAAGTGTTCCATTTTCAAGGTTCATGAAGCTCGTCAATGCTGGGAGCAGGCACACACTTGTATTTTT ATACTCAGGGATCCCAACAGGCAACTAAAACTAGACAAGGACAAAACTCCACTCAAAATATTCTGAAAGTTAGCTGATGCCCCATATTTT ATTACTCCAAATGTGTATTCACTTGCCTGAGTGCTGGCCATGAGCACTCAGTGAACACTTGCAGTACAGTGAGTGATGTCCTTGACAAGT TACTATGAAGACTCTGAGAAAAAGTAACATCCCCCACTGTCCTCAACAAGCCTGTAATCCCATGGCTGCCAGCCCTTACCATGCAACAAC ACTGCGCTAAGTGCATCGAACCACACAAAACCCTGTGAGAAAATACTGCTTCCCACTTCACACGTGAAGTAACTGAGTCTAGTTTTAGAA ATACCTAAACGAAGAGGGACAGGCACAACAAATTTGCTGGAATGTAAAGAAAGTAGATCAGTTTCTGCGTAAGCAGTAAGAAATGGCCTC ATGAGGAAGAAAGGGACATTTGCCCTGACATTTCTCAAAGACTGCTTAGGTTTTGGAGACAGAGATCCAAGGGCAGGCAAGCACAATGGT TCATGCCTGTAATTCCAGCACTTTGAGAGGCCAAGGTGGGAGGATTGCTTGAGCCCAGGAATTCAAGATTAGCCTGTGCAACACAGCAAG ACCCCATCTCTATTTTAAAAAGAGAGAGAGAGATCCAAAAGCAAAGGCATTTCAGTTTGCAAGGCCAGCATGGGAGAGGGTCTTAAAACA GAAACACACAAGGTAAGATTGGGGGATGGTACCTAGACCAGCCTAGGATCATAGGATTTGATAAAATATGCATTTGGAAAACTGGTGCTA ATTTATAGAGACTTAGAATTTCAGGCTAAGGACAAGGACTAAGAAACGAATAGCATGAACAGTATTATTGATAAACCCATCATTGCATCT TAAAGGCTCTGAAGTCTTTAGTATTGAATTAAAAAATAATTTTCACTGGACAAAACCAAAAGGTCTTTACACAACTGTCAAGCACTTTGA AATGATTCAGCAAAAAGCAGAATAAATCACTAGTGGAATTTCAATAGCATGTAGTTGTAAACCATCATGTGTCCAGCAAAATCACAAAAC AAGAGTTTATTTTAGAAGGGACTTAGGGATATTAAGAAATATAACATACAAAATAACTAAAGTTTTCTCCAAGCAAAACCAATGATCCTT TAGGGATGAACAGAAAGAAAACAAGAAATGCTTCTTTCAAAAGTTGCTACCAAGGCTTCTAAGATTTCTTTGGAATAAAGTCACTAAGAT TTGCTTCTGAGGTCAATCTTGCCAACTTTTCCACCATGCTTTTTAGGAAGGAACACCAGGTAGGGCTCAAGTACTGGTTTGGCTCCTGTC CCATTTTTTGGTCCTTTTGTAACTCCCTTTACTCAACTCCAAGTATGTCTGTGCACGGACAATGAGACGAAAGCATGCTCAATGCGAAAG CACAAATTATGTATTGAGAAATCACTACAATGCCAAATTTTTTTAAAATAAAAAAAAAATATATATATATATATATATCTTTAAGAACTC >38219_38219_6_ICOSLG-KCNJ6_ICOSLG_chr21_45649937_ENST00000407780_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=714AA_BP=299 MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAG MLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVA VAIGWVCRDRCLQHSYAGAWAVSPETELTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGN VRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRV ITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSE GEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ICOSLG-KCNJ6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ICOSLG-KCNJ6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ICOSLG-KCNJ6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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